                         SEQUENCE LISTING

<110>  NovaRock Biotherapeutics, Ltd.
 
<120>  ANTI-CLAUDIN 18 ANTIBODIES AND METHODS OF USE THEREOF

<130>  NVRB-001-WO1A

<140>  Not yet assigned
<141>  2020-01-31

<150>  62/800,359
<151>  2019-02-01

<150>  62/891,925
<151>  2019-08-26

<160>  338   

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  1

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Tyr Thr Arg Tyr 
            20                  25                  30          


Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Tyr Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  2
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  2

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ser Ile Tyr Tyr Cys Gln Ser 
                85                  90                  95      


Asn Tyr Ile Tyr Pro Phe Thr Phe Gly Ala Gly Thr Thr Leu Glu Leu 
            100                 105                 110         


Gln 
    


<210>  3
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  3

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Phe Thr Thr Ala Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  4
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  5
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  5

Glu Val Met Leu Val Glu Ser Gly Gly Gly Ile Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Arg Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ile Ile Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Gly Tyr Gly Asn Ser Phe Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  6
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  6

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  7
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  7

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Leu Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  8
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Ser Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Tyr Tyr Pro Phe Thr Phe Gly Ser Gly Thr Glu Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  9
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  9

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Leu Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Ala Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ala Tyr Gly Tyr Gly Asn Ala Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  10
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  10

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  11
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  11

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Leu Met His Trp Ile Lys Gln Arg Pro Gly Gln Ala Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Thr Thr Asp Tyr Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Leu Gly Tyr Tyr Lys Arg Asn Ala Met Asp His Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  12
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Phe Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  13
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  13

Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Thr Pro Gly Phe Thr Phe Ser Asp Phe 
            20                  25                  30          


Tyr Met Glu Trp Val Arg Gln Pro Pro Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr Glu Asn Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ile Val Ser Arg Asp Thr Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ala Cys Pro Trp Asp Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  14
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  14

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  15
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  15

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Asp Tyr Ala Phe Thr Arg Tyr 
            20                  25                  30          


Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Tyr Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  16
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Gln Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ser Ile Tyr Tyr Cys Gln Ser 
                85                  90                  95      


Asn Tyr Ile Tyr Pro Phe Thr Phe Gly Ala Gly Thr Thr Leu Glu Leu 
            100                 105                 110         


Gln 
    


<210>  17
<211>  120
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Pro Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Leu Ile His Trp Val Lys Xaa Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Ile Pro Ser Asn Gly Arg Thr Thr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Thr Lys Ala Ser Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ala Tyr Gly Tyr Gly Asn Ala Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  18
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Thr Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  19
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  19

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Lys Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Asp Pro Tyr Tyr Gly Gly Pro Arg Tyr Asn Lys Lys Phe 
    50                  55                  60                  


Met Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Asp Tyr Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  20
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ser Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  21
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  21

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Phe Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Ser Ile Glu Trp Met Lys Gln Asn His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Phe Arg Pro Tyr Asn Asp Asp Thr Lys Cys Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Val Glu Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Arg Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  22
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  22

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  23
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  23

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ala Ser Tyr 
            20                  25                  30          


Lys Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Gly Val Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  24
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  24

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Gln Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Val Asp Leu Ala Val Tyr Tyr Cys Gln Ser 
                85                  90                  95      


Ala Tyr Ser Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Val 
            100                 105                 110         


Lys 
    


<210>  25
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  25

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Ile Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Asp Ser Lys Thr Ser Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Arg Gln Glu Arg Ile Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  26
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  26

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Phe Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  27
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  27

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Ile Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Asp Ser Lys Asn Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Arg Gln Glu Arg Ile Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  28
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  28

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Val Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  29
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  29

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ile Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Ile Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Arg Gln Glu Arg Ile Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  30
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  30

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Val Ser Gln Asn Ile Asp Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  31
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  31

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Leu Ile Glu Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Gly Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Val Lys Gly Asn Ala Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  32
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  32

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Ser Tyr Ser Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Thr 
    


<210>  33
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  33

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ile Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Asn Pro Tyr Asn Asp Gly Ile Glu Tyr Ser Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Lys Leu Arg Gln Glu Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  34
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  34

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  35
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  35

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Asn Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Tyr Tyr Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  36
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  36

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Asn 
                85                  90                  95      


Asp Tyr Thr Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  37
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  37

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Ser Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Gly Lys Arg Asn Ala Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  38
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  38

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile 
65                  70                  75                  80  


Ile Ser Ser Val Gln Val Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Phe Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  39
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  39

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Asp Pro Tyr Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Cys Tyr Arg Phe Phe Ala Val Trp Gly Ala Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  40
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  40

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  41
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  41

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Asn Gly Asp Ser Ser Ser Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Ile Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Arg Gly Asn Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  42
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  42

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Trp Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Val Gln Thr Glu Asp Leu Ala Val Tyr Tyr Cys Gln Ile 
                85                  90                  95      


Gly Tyr Thr Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  43
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  43

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr His Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Lys Tyr Asp Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  44
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  44

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Asn Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  45
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  45

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Arg Tyr 
            20                  25                  30          


Asn Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Tyr Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Tyr Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  46
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  46

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ser Ile Tyr Tyr Cys Gln Ser 
                85                  90                  95      


Asn Tyr Ile Tyr Pro Phe Thr Phe Gly Ala Gly Thr Thr Leu Glu Leu 
            100                 105                 110         


Gln 
    


<210>  47
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  47

Gly Tyr Ala Tyr Thr Arg Tyr Asn 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  48

Ile Asp Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  49
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  49

Ala Arg Gly Gly Tyr Tyr Gly Asn Ala Met Asp Tyr 
1               5                   10          


<210>  50
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  50

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  51
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  51

Trp Ala Ser 
1           


<210>  52
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  52

Gln Ser Asn Tyr Ile Tyr Pro Phe Thr 
1               5                   


<210>  53
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  53

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  54
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  54

Ile Trp Ala Gly Gly Ser Thr 
1               5           


<210>  55
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  55

Ala Arg Asp Phe Thr Thr Ala Thr Gly Phe Asp Tyr 
1               5                   10          


<210>  56
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  56

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  57
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  57

Gly Ala Ser 
1           


<210>  58
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  58

Gln Asn Asp His Ser Tyr Pro Phe Thr 
1               5                   


<210>  59
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  59

Gly Phe Thr Leu Ser Ser Tyr Thr 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  60

Ile Ile Ile Gly Gly Ser Tyr Thr 
1               5               


<210>  61
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  61

Ala Arg Gln Gly Tyr Gly Asn Ser Phe Pro Tyr 
1               5                   10      


<210>  62
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  62

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  63
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  63

Trp Ala Ser 
1           


<210>  64
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  64

Gln Asn Asp Tyr Ser Tyr Pro Phe Thr 
1               5                   


<210>  65
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  65

Gly Tyr Ser Phe Thr Gly Tyr Asn 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  66

Ile Asp Pro Tyr Tyr Gly Gly Thr 
1               5               


<210>  67
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  67

Ala Arg Leu Gly Leu Gly Asn Ala Met Asp Tyr 
1               5                   10      


<210>  68
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  68

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Ser Tyr 
1               5                   10          


<210>  69
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  69

Trp Ala Ser 
1           


<210>  70
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  70

Gln Asn Asp Tyr Tyr Tyr Pro Phe Thr 
1               5                   


<210>  71
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  71

Gly Tyr Thr Phe Thr Arg Tyr Leu 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  72

Ile Asn Pro Ser Asn Gly Arg Thr 
1               5               


<210>  73
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  73

Ala Arg Leu Ala Tyr Gly Tyr Gly Asn Ala Val Asp Tyr 
1               5                   10              


<210>  74
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  74

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  75
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  75

Gly Ala Ser 
1           


<210>  76
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  76

Gln Asn Asp His Ser Tyr Pro Leu Thr 
1               5                   


<210>  77
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  77

Gly Tyr Thr Phe Thr Ser Tyr Leu 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  78

Ile Asn Pro Thr Thr Asp Tyr Thr 
1               5               


<210>  79
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  79

Gly Arg Leu Gly Tyr Tyr Lys Arg Asn Ala Met Asp His 
1               5                   10              


<210>  80
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  80

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  81
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  81

Gly Ala Ser 
1           


<210>  82
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  82

Gln Asn Asp His Phe Tyr Pro Leu Thr 
1               5                   


<210>  83
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  83

Gly Phe Thr Phe Ser Asp Phe Tyr 
1               5               


<210>  84
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  84

Ser Arg Asn Lys Ala Asn Asp Tyr Thr Thr 
1               5                   10  


<210>  85
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  85

Ala Arg Asp Ala Cys Pro Trp Asp Trp Phe Ala Tyr 
1               5                   10          


<210>  86
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  86

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  87
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  87

Trp Ala Ser 
1           


<210>  88
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  88

Gln Asn Asp Tyr Ser Tyr Pro Phe Thr 
1               5                   


<210>  89
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  89

Asp Tyr Ala Phe Thr Arg Tyr Asn 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  90

Ile Asp Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  91
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  91

Ala Arg Gly Gly Tyr Tyr Gly Asn Ala Met Asp Tyr 
1               5                   10          


<210>  92
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  92

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  93
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  93

Trp Ala Ser 
1           


<210>  94
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  94

Gln Ser Asn Tyr Ile Tyr Pro Phe Thr 
1               5                   


<210>  95
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  95

Gly Tyr Thr Phe Thr Ser Tyr Leu 
1               5               


<210>  96
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  96

Ile Ile Pro Ser Asn Gly Arg Thr 
1               5               


<210>  97
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  97

Ala Arg Leu Ala Tyr Gly Tyr Gly Asn Ala Val Asp Tyr 
1               5                   10              


<210>  98
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  98

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  99
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  99

Gly Ala Ser 
1           


<210>  100
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  100

Gln Asn Asp His Thr Tyr Pro Leu Thr 
1               5                   


<210>  101
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  101

Gly Tyr Ser Phe Thr Gly Tyr Lys 
1               5               


<210>  102
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  102

Ile Asp Pro Tyr Tyr Gly Gly Pro 
1               5               


<210>  103
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  103

Ala Arg Leu Asp Tyr Gly Asn Ser Phe Ala Tyr 
1               5                   10      


<210>  104
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  104

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  105
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  105

Gly Ala Ser 
1           


<210>  106
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  106

Gln Asn Asp His Ser Tyr Pro Phe Thr 
1               5                   


<210>  107
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  107

Gly Tyr Thr Phe Thr Thr Tyr Ser 
1               5               


<210>  108
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  108

Phe Arg Pro Tyr Asn Asp Asp Thr 
1               5               


<210>  109
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  109

Ala Arg Gly Ser Tyr Gly Asn Ser Phe Ala Tyr 
1               5                   10      


<210>  110
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  110

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  111
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  111

Gly Ala Ser 
1           


<210>  112
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  112

Gln Asn Asp His Ser Tyr Pro Phe Thr 
1               5                   


<210>  113
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  113

Gly Tyr Ala Phe Ala Ser Tyr Lys 
1               5               


<210>  114
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  114

Ile Asp Pro Tyr Asn Gly Val Thr 
1               5               


<210>  115
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  115

Ala Arg Gly Ala Tyr Tyr Gly Asn Ser Phe Asp Tyr 
1               5                   10          


<210>  116
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  116

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  117
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  117

Trp Ala Ser 
1           


<210>  118
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  118

Gln Ser Ala Tyr Ser Phe Pro Tyr Thr 
1               5                   


<210>  119
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  119

Gly Tyr Thr Phe Thr Arg Tyr Ile 
1               5               


<210>  120
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  120

Phe Asn Pro Tyr Asn Asp Asp Ser 
1               5               


<210>  121
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  121

Ala Lys Leu Arg Gln Glu Arg Ile Ala Tyr 
1               5                   10  


<210>  122
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  122

Gln Asn Ile Asp Val Trp 
1               5       


<210>  123
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  123

Lys Ala Ser 
1           


<210>  124
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  124

Gln Gln Gly Gln Ser Tyr Pro Leu Thr 
1               5                   


<210>  125
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  125

Gly Tyr Thr Phe Thr Arg Tyr Ile 
1               5               


<210>  126
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  126

Phe Asn Pro Tyr Asn Asp Asp Ser 
1               5               


<210>  127
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  127

Ala Lys Leu Arg Gln Glu Arg Ile Ala Tyr 
1               5                   10  


<210>  128
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  128

Gln Asn Ile Asp Val Trp 
1               5       


<210>  129
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  129

Lys Ala Ser 
1           


<210>  130
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  130

Gln Gln Gly Gln Ser Tyr Pro Leu Thr 
1               5                   


<210>  131
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  131

Gln Gln Gly Gln Ser Tyr Pro Leu Thr 
1               5                   


<210>  132
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  132

Phe Asn Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  133
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  133

Ala Lys Leu Arg Gln Glu Arg Ile Ala Tyr 
1               5                   10  


<210>  134
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  134

Gln Asn Ile Asp Val Trp 
1               5       


<210>  135
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  135

Lys Ala Ser 
1           


<210>  136
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  136

Gln Gln Gly Gln Ser Tyr Pro Leu Thr 
1               5                   


<210>  137
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  137

Gly Tyr Ala Phe Thr Asn Tyr Leu 
1               5               


<210>  138
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  138

Ile Asn Pro Gly Ser Gly Gly Thr 
1               5               


<210>  139
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  139

Ala Arg Tyr Val Lys Gly Asn Ala Leu Asp Tyr 
1               5                   10      


<210>  140
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  140

Gln Ser Leu Phe Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  141
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  141

Trp Ala Ser 
1           


<210>  142
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  142

Gln Asn Ser Tyr Ser Phe Pro Leu Thr 
1               5                   


<210>  143
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  143

Gly Tyr Thr Phe Thr Asn Tyr Ile 
1               5               


<210>  144
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  144

Phe Asn Pro Tyr Asn Asp Gly Ile 
1               5               


<210>  145
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  145

Ser Lys Leu Arg Gln Glu Arg Phe Ala Tyr 
1               5                   10  


<210>  146
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  146

Gln Asn Ile Asn Val Trp 
1               5       


<210>  147
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  147

Lys Ala Ser 
1           


<210>  148
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  148

Gln Gln Gly Gln Ser Tyr Pro Leu Thr 
1               5                   


<210>  149
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  149

Gly Phe Ser Leu Ile Ser Tyr Gly 
1               5               


<210>  150
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  150

Ile Trp Ala Gly Gly Asn Thr 
1               5           


<210>  151
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  151

Ala Arg Val Tyr Tyr Gly Asn Ser Phe Asp Tyr 
1               5                   10      


<210>  152
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  152

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  153
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  153

Trp Ala Ser 
1           


<210>  154
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  154

His Asn Asp Tyr Thr Tyr Pro Leu Thr 
1               5                   


<210>  155
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  155

Gly Tyr Thr Phe Thr Ser Tyr Val 
1               5               


<210>  156
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  156

Ile Asn Pro Tyr Asn Asp Gly Ser 
1               5               


<210>  157
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  157

Ala Arg Glu Gly Tyr Gly Lys Arg Asn Ala Leu Asp Tyr 
1               5                   10              


<210>  158
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  158

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  159
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  159

Gly Ala Ser 
1           


<210>  160
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  160

Gln Asn Asp His Phe Tyr Pro Leu Thr 
1               5                   


<210>  161
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  161

Gly Tyr Ser Phe Thr Ser Tyr Tyr 
1               5               


<210>  162
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  162

Phe Asp Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  163
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  163

Ala Cys Tyr Arg Phe Phe Ala Val 
1               5               


<210>  164
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  164

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  165
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  165

Trp Ala Ser 
1           


<210>  166
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  166

Gln Asn Asp Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  167
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  167

Gly Phe Thr Phe Ser Thr Phe Gly 
1               5               


<210>  168
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  168

Ile Asn Gly Asp Ser Ser Ser Ile 
1               5               


<210>  169
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  169

Ala Arg Phe Ala Arg Gly Asn Ser Phe Asp Tyr 
1               5                   10      


<210>  170
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  170

Gln Ser Leu Phe Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  171
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  171

Trp Ala Ser 
1           


<210>  172
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  172

Gln Ile Gly Tyr Thr Tyr Pro Leu Thr 
1               5                   


<210>  173
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  173

Gly Phe Ser Leu Thr Ser Asn Gly 
1               5               


<210>  174
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  174

Ile Trp Ala Gly Gly Ser Thr 
1               5           


<210>  175
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  175

Ala Arg Asp Lys Tyr Asp Gly Thr Gly Phe Asp Tyr 
1               5                   10          


<210>  176
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  176

Ser Ser Val Ser Asn 
1               5   


<210>  177
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  177

Asp Thr Ser 
1           


<210>  178
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  178

Gln Gln Trp Ser Ser Tyr Pro Tyr Thr 
1               5                   


<210>  179
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  179

Gly Tyr Ala Phe Thr Arg Tyr Asn 
1               5               


<210>  180
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  180

Ile Asp Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  181
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  181

Ala Arg Gly Gly Tyr Tyr Gly Asn Ala Met Asp Tyr 
1               5                   10          


<210>  182
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  182

Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  183
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  183

Trp Ala Ser 
1           


<210>  184
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  184

Gln Ser Asn Tyr Ile Tyr Pro Phe Thr 
1               5                   


<210>  185
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  185

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Asn 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Asp Ile Leu Thr Gly Tyr Asp Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala 
        115                 120                 125 


<210>  186
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  186

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Ser 
            20                  25                  30          


Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Arg Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Ala Pro Asp Glu Ser Asn Tyr Tyr Cys Val Leu Tyr Met Gly Ser 
                85                  90                  95      


Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  187
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  187

Gln Leu Arg Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Arg Ser Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Leu Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Thr Ser Val Thr Ala Thr Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gln Thr Leu Arg Tyr Phe Asp Trp Leu Ser Pro Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  188
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  188

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Asp Tyr Asn Leu Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  189
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  189

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Asp Gly Pro Ile Ser Ser Ser 
            20                  25                  30          


Arg Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Phe His Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Ala Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Val Leu Arg Tyr Phe Asp Trp Leu Gly Phe Phe Asp 
            100                 105                 110         


Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  190
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  190

Glu Ile Val Met Thr Gln Ser Pro Ala Ile Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Ala Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Thr Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Asn Leu Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Phe Lys 
            100                 105             


<210>  191
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  191

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asn Tyr Asp Ile Leu Thr Gly Arg Asp Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  192
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  192

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Asn Ser Gly Ser Val Ser Thr Ser 
            20                  25                  30          


Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Ser Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Asp Ser Asp Tyr Tyr Cys Val Leu Tyr Met Gly Ser 
                85                  90                  95      


Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  193
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  193

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Arg Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Tyr Asp Ile Phe Thr Thr Tyr Tyr Pro Arg Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  194
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  194

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Thr Thr Tyr Tyr Cys Leu Gln His Asn Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Glu Leu Glu Ile Arg 
            100                 105         


<210>  195
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  195

Gln Met Gln Leu Arg Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Asn Gly Pro Ile Ser Ser Ser 
            20                  25                  30          


Arg Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Phe His Tyr Ser Gly Ser Thr Tyr Tyr Lys Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Ala Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  


Ser Leu Glu Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Val Leu Arg Tyr Phe Asp Trp Leu Gly Tyr Phe Asp 
            100                 105                 110         


Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  196
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  196

Glu Phe Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Arg Ser Asn 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Ala Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Asn Leu Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  197
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  197

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Lys Pro Leu Leu Gly Gly Thr Gly Leu Trp Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  198
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  198

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ser Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  199
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  199

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Asp Val Leu Thr Ala Tyr Pro Tyr Tyr Phe Tyr Tyr 
            100                 105                 110         


Asn Met Asp Val Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  200
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  200

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Asn Ser Gly Ser Val Ser Thr Ser 
            20                  25                  30          


Tyr Tyr Pro Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Ser Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val Leu Tyr Met Gly Ser 
                85                  90                  95      


Gly Ile Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  201
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  201

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Leu Ser Gly Ser Gly Arg Ser Thr Tyr Tyr Ala Ala Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Leu Ser Tyr Tyr His Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Thr Ser 
        115                 120 


<210>  202
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  202

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Pro Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


His Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Gln Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  203
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  203

Glu Val Gln Leu Ser Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Leu Ser Gly Ser Gly Arg Ser Thr Tyr Tyr Ala Ala Ser Ile 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Leu Ser Tyr Tyr His Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  204
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  204

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Pro Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr His Cys Gln Gln Val Lys Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  205
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  205

Gln Val His Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Asn Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Val Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Tyr Asp Ile Leu Thr Gly Tyr Tyr Pro Leu Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  206
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  206

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Arg Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Thr Ala Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Gln Leu Thr Ala Leu 
            100                 105     


<210>  207
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  207

Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Ala Pro Thr Leu Trp Trp Phe Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  208
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  208

Asp Ile Gln Val Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Leu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  209
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  209

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ala Cys Ala Ala Ser Gly Phe Pro Leu Arg Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Thr Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Gly Tyr Asp Ile Leu Thr Gly Tyr Tyr Asp Tyr Phe 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  210
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  210

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  211
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  211

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Gly Tyr Asp Ile Leu Thr Thr Tyr Tyr Asp Tyr Phe 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Pro Glu Phe Gln His Thr Gly Gly 
        115                 120                 125             


<210>  212
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  212

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Ser Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  213

<400>  213
000

<210>  214

<400>  214
000

<210>  215
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  215

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ile Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Gly Gly Ser Gly Ser Asn Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Gly Tyr Asp Ile Leu Thr Gly Tyr Tyr Asn Tyr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Ile Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  216
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  216

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  217
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  217

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Val Ser Gly Tyr Thr Leu Thr Ala Leu 
            20                  25                  30          


Ser Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Arg Leu Arg Tyr Phe Asp Trp Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Pro Val Thr Val Ser Ser 
        115             


<210>  218
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  218

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Lys Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Thr Gln Gly 
                85                  90                  95      


Thr Gln Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  219
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  219

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Arg Val Ser Gly Tyr Thr Leu Ser Ala Leu 
            20                  25                  30          


Ser Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Lys Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Thr Leu Arg Tyr Phe Asp Trp Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Pro Val Thr Val Ser Ser 
        115             


<210>  220
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  220

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Ser Trp Leu Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Lys Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Thr Gln Gly 
                85                  90                  95      


Thr Gln Phe Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  221
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  221

Gly Phe Thr Phe Ser Asn Tyr Gly 
1               5               


<210>  222
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  222

Ile Trp Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  223
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  223

Ala Arg Arg Gly Tyr Asp Ile Leu Thr Gly Tyr Asp Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  224
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  224

Ser Gly Ser Val Ser Thr Ser Tyr Tyr 
1               5                   


<210>  225
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  225

Arg Thr Asn 
1           


<210>  226
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  226

Val Leu Tyr Met Gly Ser Gly Ile Trp Val 
1               5                   10  


<210>  227
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  227

Gly Gly Ser Ile Ser Ser Ser Arg Ser Tyr 
1               5                   10  


<210>  228
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  228

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  229
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  229

Ala Arg Gln Thr Leu Arg Tyr Phe Asp Trp Leu Ser Pro Phe Asp Tyr 
1               5                   10                  15      


<210>  230
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  230

Gln Ser Val Arg Ser Asn Tyr 
1               5           


<210>  231
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  231

Gly Thr Ser 
1           


<210>  232
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  232

Gln Gln Asp Tyr Asn Leu Pro Ile Thr 
1               5                   


<210>  233
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  233

Asp Gly Pro Ile Ser Ser Ser Arg Tyr Tyr 
1               5                   10  


<210>  234
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  234

Phe His Tyr Ser Gly Ser Thr 
1               5           


<210>  235
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  235

Ala Arg Leu Val Leu Arg Tyr Phe Asp Trp Leu Gly Phe Phe Asp Leu 
1               5                   10                  15      


<210>  236
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  236

Gln Ser Val Arg Ser Ser Tyr 
1               5           


<210>  237
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  237

Gly Thr Ser 
1           


<210>  238
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  238

Gln Gln Asp Tyr Asn Leu Pro Ile Thr 
1               5                   


<210>  239
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  239

Gly Phe Thr Phe Ser Phe Tyr Gly 
1               5               


<210>  240
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  240

Ile Trp Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  241
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  241

Ala Arg Arg Asn Tyr Asp Ile Leu Thr Gly Arg Asp Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  242
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  242

Ser Gly Ser Val Ser Thr Ser Tyr Tyr 
1               5                   


<210>  243
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  243

Ser Thr Asn 
1           


<210>  244
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  244

Val Leu Tyr Met Gly Ser Gly Ile Trp Val 
1               5                   10  


<210>  245
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  245

Gly Tyr Thr Phe Thr Ser Ser Tyr 
1               5               


<210>  246
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  246

Ile Asn Pro Ser Gly Gly Arg Thr 
1               5               


<210>  247
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  247

Ala Arg Asp His Tyr Asp Ile Phe Thr Thr Tyr Tyr Pro Arg Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  248
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  248

Gln Gly Ile Arg Asn Asp 
1               5       


<210>  249
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  249

Ala Ala Ser 
1           


<210>  250
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  250

Leu Gln His Asn Ser Phe Pro Phe Thr 
1               5                   


<210>  251
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  251

Asn Gly Pro Ile Ser Ser Ser Arg Tyr Tyr 
1               5                   10  


<210>  252
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  252

Phe His Tyr Ser Gly Ser Thr 
1               5           


<210>  253
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  253

Ala Arg Leu Val Leu Arg Tyr Phe Asp Trp Leu Gly Tyr Phe Asp Leu 
1               5                   10                  15      


<210>  254
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  254

Gln Ser Ile Arg Ser Asn Tyr 
1               5           


<210>  255
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  255

Gly Ala Ser 
1           


<210>  256
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  256

Gln Gln Asp Tyr Asn Leu Pro Ile Thr 
1               5                   


<210>  257
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  257

Gly Phe Thr Phe Ser Ser Tyr Val 
1               5               


<210>  258
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  258

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  259
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  259

Gly Lys Pro Leu Leu Gly Gly Thr Gly Leu Trp Asp Tyr 
1               5                   10              


<210>  260
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  260

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  261
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  261

Asp Ser Ser 
1           


<210>  262
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  262

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  263
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  263

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  264
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  264

Ile Trp Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  265
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  265

Ala Arg Arg Tyr Asp Val Leu Thr Ala Tyr Pro Tyr Tyr Phe Tyr Tyr 
1               5                   10                  15      


Asn Met Asp Val 
            20  


<210>  266
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  266

Ser Gly Ser Val Ser Thr Ser Tyr Tyr 
1               5                   


<210>  267
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  267

Ser Thr Asn 
1           


<210>  268
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  268

Val Leu Tyr Met Gly Ser Gly Ile Trp Val 
1               5                   10  


<210>  269
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  269

Gly Phe Thr Phe Ser Ser Phe Ala 
1               5               


<210>  270
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  270

Leu Ser Gly Ser Gly Arg Ser Thr 
1               5               


<210>  271
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  271

Ala Lys Ser Leu Ser Tyr Tyr His Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  272
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  272

Gln Gly Ile Ser Asn Phe 
1               5       


<210>  273
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  273

Ser Ala Ser 
1           


<210>  274
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  274

Gln Gln Val Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  275
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  275

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  276
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  276

Leu Ser Gly Ser Gly Arg Ser Thr 
1               5               


<210>  277
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  277

Ala Lys Ser Leu Ser Tyr Tyr His Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  278
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  278

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  279
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  279

Ser Ala Ser 
1           


<210>  280
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  280

Gln Gln Val Lys Thr Tyr Pro Leu Thr 
1               5                   


<210>  281
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  281

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  282
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  282

Ile Asn Pro Ser Gly Gly Asn Thr 
1               5               


<210>  283
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  283

Ala Arg Asp His Tyr Asp Ile Leu Thr Gly Tyr Tyr Pro Leu Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  284
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  284

Asn Ile Gly Ser Lys Asn 
1               5       


<210>  285
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  285

Arg Asp Ser 
1           


<210>  286
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  286

Gln Val Trp Asp Ser Ser Thr Ala Val 
1               5                   


<210>  287
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  287

Gly Phe Thr Phe Ser Ser Tyr Val 
1               5               


<210>  288
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  288

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  289
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  289

Thr Lys Ala Pro Thr Leu Trp Trp Phe Phe Asp Leu 
1               5                   10          


<210>  290
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  290

Gln Gly Ile Arg Ser Tyr 
1               5       


<210>  291
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  291

Ala Ala Ser 
1           


<210>  292
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  292

Gln Gln Leu Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  293
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  293

Gly Phe Pro Leu Arg Ser Tyr Ala 
1               5               


<210>  294
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  294

Thr Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  295
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  295

Ala Lys Asp Arg Gly Tyr Asp Ile Leu Thr Gly Tyr Tyr Asp Tyr Phe 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  296
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  296

Gln Gly Ile Arg Asn Asp 
1               5       


<210>  297
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  297

Ala Ala Ser 
1           


<210>  298
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  298

Leu Gln His Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  299
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  299

Gly Ile Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  300
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  300

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  301
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  301

Ala Lys Asp Arg Gly Tyr Asp Ile Leu Thr Thr Tyr Tyr Asp Tyr Phe 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  302
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  302

Gln Gly Ile Arg Asn Asp 
1               5       


<210>  303
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  303

Ala Ala Ser 
1           


<210>  304
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  304

Leu Gln His Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  305

<400>  305
000

<210>  306

<400>  306
000

<210>  307

<400>  307
000

<210>  308

<400>  308
000

<210>  309

<400>  309
000

<210>  310

<400>  310
000

<210>  311
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  311

Gly Leu Ile Phe Ser Ser Tyr Ala 
1               5               


<210>  312
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  312

Ile Gly Gly Ser Gly Ser Asn Thr 
1               5               


<210>  313
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  313

Ala Lys Asp Arg Gly Tyr Asp Ile Leu Thr Gly Tyr Tyr Asn Tyr Tyr 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  314
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  314

Gln Gly Ile Arg Asn Asp 
1               5       


<210>  315
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  315

Ala Ala Ser 
1           


<210>  316
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  316

Leu Gln His Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  317
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  317

Gly Tyr Thr Leu Thr Ala Leu Ser 
1               5               


<210>  318
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  318

Phe Asp Pro Glu Asp Gly Glu Thr 
1               5               


<210>  319
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  319

Ala Thr Arg Leu Arg Tyr Phe Asp Trp Asn Tyr 
1               5                   10      


<210>  320
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  320

Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  321
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  321

Lys Val Ser 
1           


<210>  322
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  322

Thr Gln Gly Thr Gln Phe Pro Arg Thr 
1               5                   


<210>  323
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  323

Gly Tyr Thr Leu Ser Ala Leu Ser 
1               5               


<210>  324
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  324

Phe Asp Pro Glu Asp Gly Lys Thr 
1               5               


<210>  325
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  325

Ala Thr Thr Leu Arg Tyr Phe Asp Trp Asn Tyr 
1               5                   10      


<210>  326
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  326

Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  327
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  327

Lys Val Ser 
1           


<210>  328
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  328

Thr Gln Gly Thr Gln Phe Pro Arg Thr 
1               5                   


<210>  329
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  329

Met Ala Val Thr Ala Cys Gln Gly Leu Gly Phe Val Val Ser Leu Ile 
1               5                   10                  15      


Gly Ile Ala Gly Ile Ile Ala Ala Thr Cys Met Asp Gln Trp Ser Thr 
            20                  25                  30          


Gln Asp Leu Tyr Asn Asn Pro Val Thr Ala Val Phe Asn Tyr Gln Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Glu Ser Ser Gly Phe Thr Glu Cys Arg 
    50                  55                  60                  


Gly Tyr Phe Thr Leu Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 
    130                 135                 140                 


Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly 
145                 150                 155                 160 


Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe 
                165                 170                 175     


Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met 
            180                 185                 190         


Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala 
        195                 200                 205             


Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 
    210                 215                 220                 


Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile 
225                 230                 235                 240 


Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser 
                245                 250                 255     


Lys His Asp Tyr Val 
            260     


<210>  330
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Ser Thr Thr Thr Cys Gln Val Val Ala Phe Leu Leu Ser Ile Leu 
1               5                   10                  15      


Gly Leu Ala Gly Cys Ile Ala Ala Thr Gly Met Asp Met Trp Ser Thr 
            20                  25                  30          


Gln Asp Leu Tyr Asp Asn Pro Val Thr Ser Val Phe Gln Tyr Glu Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Gln Ser Ser Gly Phe Thr Glu Cys Arg 
    50                  55                  60                  


Pro Tyr Phe Thr Ile Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 
    130                 135                 140                 


Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly 
145                 150                 155                 160 


Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe 
                165                 170                 175     


Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met 
            180                 185                 190         


Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala 
        195                 200                 205             


Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 
    210                 215                 220                 


Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile 
225                 230                 235                 240 


Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser 
                245                 250                 255     


Lys His Asp Tyr Val 
            260     


<210>  331
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  331

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  332
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  332

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  333
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  333

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  334
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  334

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  335
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  335

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
1               5                   10                  15      


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
            20                  25                  30          


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
        35                  40                  45              


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
    50                  55                  60                  


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
65                  70                  75                  80  


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
                85                  90                  95      


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105             


<210>  336
<211>  450
<212>  PRT
<213>  Artificial

<220>
<223>  NBL-014 heavy chain

<400>  336

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Leu Ser Gly Ser Gly Arg Ser Thr Tyr Tyr Ala Ala Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Leu Ser Tyr Tyr His Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Thr Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Val Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Leu Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Pro Glu Glu Gln Tyr Asn Ser Thr Leu Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Leu Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  337
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  NBL-014 light chain

<400>  337

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Pro Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


His Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  


Gln Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  338
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  338

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Leu Ser Gly Ser Gly Arg Ser Thr Tyr Tyr Ala Ala Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Leu Ser Tyr Tyr His Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Thr Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Val Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Leu Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Pro Glu Glu Gln Tyr Asn Ser Thr Leu Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Leu Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


