                         SEQUENCE LISTING

<110>  AvroBio, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR TREATING NEUROCOGNITIVE DISORDERS

<130>  51182-020WO2

<150>  62/800,177
<151>  2019-02-01

<160>  106   

<170>  PatentIn version 3.5

<210>  1
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr 
            340                 345                 350         


Thr Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala 
        355                 360                 365             


Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp 
    370                 375                 380                 


Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala 
385                 390                 395                 400 


Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala 
                405                 410                 415     


Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile 
            420                 425                 430         


Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn 
        435                 440                 445             


Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met 
    450                 455                 460                 


Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu 
465                 470                 475                 480 


Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys 
                485                 490                 495     


Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe 
            500                 505                 510         


Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser 
        515                 520                 525             


Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser 
    530                 535                 540                 


Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp 
545                 550                 555                 560 


Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val 
                565                 570                 575     


Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala 
            580                 585                 590         


Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro 
        595                 600                 605             


Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe 
    610                 615                 620                 


Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val 
625                 630                 635                 640 


Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser 
                645                 650                 655     


Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp 
            660                 665                 670         


Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
        675                 680                 685             


Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
    690                 695                 700                 


Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu 
705                 710                 715                 720 


Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
                725                 730                 735     


Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met 
            740                 745                 750         


Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met 
        755                 760                 765             


Gln Asn 
    770 


<210>  2
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn 
            20                  25                  30          


Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu 
        35                  40                  45              


Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu 
    50                  55                  60                  


Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
65                  70                  75                  80  


His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val 
                85                  90                  95      


Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln 
            100                 105                 110         


Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg 
        115                 120                 125             


Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val 
    130                 135                 140                 


Val Met Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys 
145                 150                 155                 160 


Val Ile His Ala Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe 
                165                 170                 175     


Phe Ser Phe Ile Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala 
            180                 185                 190         


Val Asp Tyr Ile Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val 
        195                 200                 205             


Gly Met Ile Ser Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala 
    210                 215                 220                 


Tyr Leu Ile Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr 
225                 230                 235                 240 


Leu Pro Glu Trp Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr 
                245                 250                 255     


Asp Leu Val Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val 
            260                 265                 270         


Glu Thr Ala Gln Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr 
        275                 280                 285             


Ser Ser Thr Met Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu 
    290                 295                 300                 


Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr 
305                 310                 315                 320 


Glu Arg Glu Ser Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Trp Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg 
            340                 345                 350         


Ser Thr Pro Glu Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile 
        355                 360                 365             


Leu Ala Gly Glu Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly 
    370                 375                 380                 


Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala 
385                 390                 395                 400 


Ser Gly Asp Trp Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile 
                405                 410                 415     


Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu 
            420                 425                 430         


Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala 
        435                 440                 445             


Thr Asp Tyr Leu Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln 
    450                 455                 460                 


Phe Tyr Ile 
465         


<210>  3
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Met Leu Thr Phe Met Ala Ser Asp Ser Glu Glu Glu Val Cys Asp Glu 
1               5                   10                  15      


Arg Thr Ser Leu Met Ser Ala Glu Ser Pro Thr Pro Arg Ser Cys Gln 
            20                  25                  30          


Glu Gly Arg Gln Gly Pro Glu Asp Gly Glu Asn Thr Ala Gln Trp Arg 
        35                  40                  45              


Ser Gln Glu Asn Glu Glu Asp Gly Glu Glu Asp Pro Asp Arg Tyr Val 
    50                  55                  60                  


Cys Ser Gly Val Pro Gly Arg Pro Pro Gly Leu Glu Glu Glu Leu Thr 
65                  70                  75                  80  


Leu Lys Tyr Gly Ala Lys His Val Ile Met Leu Phe Val Pro Val Thr 
                85                  90                  95      


Leu Cys Met Ile Val Val Val Ala Thr Ile Lys Ser Val Arg Phe Tyr 
            100                 105                 110         


Thr Glu Lys Asn Gly Gln Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr 
        115                 120                 125             


Pro Ser Val Gly Gln Arg Leu Leu Asn Ser Val Leu Asn Thr Leu Ile 
    130                 135                 140                 


Met Ile Ser Val Ile Val Val Met Thr Ile Phe Leu Val Val Leu Tyr 
145                 150                 155                 160 


Lys Tyr Arg Cys Tyr Lys Phe Ile His Gly Trp Leu Ile Met Ser Ser 
                165                 170                 175     


Leu Met Leu Leu Phe Leu Phe Thr Tyr Ile Tyr Leu Gly Glu Val Leu 
            180                 185                 190         


Lys Thr Tyr Asn Val Ala Met Asp Tyr Pro Thr Leu Leu Leu Thr Val 
        195                 200                 205             


Trp Asn Phe Gly Ala Val Gly Met Val Cys Ile His Trp Lys Gly Pro 
    210                 215                 220                 


Leu Val Leu Gln Gln Ala Tyr Leu Ile Met Ile Ser Ala Leu Met Ala 
225                 230                 235                 240 


Leu Val Phe Ile Lys Tyr Leu Pro Glu Trp Ser Ala Trp Val Ile Leu 
                245                 250                 255     


Gly Ala Ile Ser Val Tyr Asp Leu Val Ala Val Leu Cys Pro Lys Gly 
            260                 265                 270         


Pro Leu Arg Met Leu Val Glu Thr Ala Gln Glu Arg Asn Glu Pro Ile 
        275                 280                 285             


Phe Pro Ala Leu Ile Tyr Ser Ser Ala Met Val Trp Thr Val Gly Met 
    290                 295                 300                 


Ala Lys Leu Asp Pro Ser Ser Gln Gly Ala Leu Gln Leu Pro Tyr Asp 
305                 310                 315                 320 


Pro Glu Met Glu Glu Asp Ser Tyr Asp Ser Phe Gly Glu Pro Ser Tyr 
                325                 330                 335     


Pro Glu Val Phe Glu Pro Pro Leu Thr Gly Tyr Pro Gly Glu Glu Leu 
            340                 345                 350         


Glu Glu Glu Glu Glu Arg Gly Val Lys Leu Gly Leu Gly Asp Phe Ile 
        355                 360                 365             


Phe Tyr Ser Val Leu Val Gly Lys Ala Ala Ala Thr Gly Ser Gly Asp 
    370                 375                 380                 


Trp Asn Thr Thr Leu Ala Cys Phe Val Ala Ile Leu Ile Gly Leu Cys 
385                 390                 395                 400 


Leu Thr Leu Leu Leu Leu Ala Val Phe Lys Lys Ala Leu Pro Ala Leu 
                405                 410                 415     


Pro Ile Ser Ile Thr Phe Gly Leu Ile Phe Tyr Phe Ser Thr Asp Asn 
            420                 425                 430         


Leu Val Arg Pro Phe Met Asp Thr Leu Ala Ser His Gln Leu Tyr Ile 
        435                 440                 445             


<210>  4
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Gly Asn Val Leu Ala Ala Ser Ser Pro Pro Ala Gly Pro Pro Pro 
1               5                   10                  15      


Pro Pro Ala Pro Ala Leu Val Gly Leu Pro Pro Pro Pro Pro Ser Pro 
            20                  25                  30          


Pro Gly Phe Thr Leu Pro Pro Leu Gly Gly Ser Leu Gly Ala Gly Thr 
        35                  40                  45              


Ser Thr Ser Arg Ser Ser Glu Arg Thr Pro Gly Ala Ala Thr Ala Ser 
    50                  55                  60                  


Ala Ser Gly Ala Ala Glu Asp Gly Ala Cys Gly Cys Leu Pro Asn Pro 
65                  70                  75                  80  


Gly Thr Phe Glu Glu Cys His Arg Lys Cys Lys Glu Leu Phe Pro Ile 
                85                  90                  95      


Gln Met Glu Gly Val Lys Leu Thr Val Asn Lys Gly Leu Ser Asn His 
            100                 105                 110         


Phe Gln Val Asn His Thr Val Ala Leu Ser Thr Ile Gly Glu Ser Asn 
        115                 120                 125             


Tyr His Phe Gly Val Thr Tyr Val Gly Thr Lys Gln Leu Ser Pro Thr 
    130                 135                 140                 


Glu Ala Phe Pro Val Leu Val Gly Asp Met Asp Asn Ser Gly Ser Leu 
145                 150                 155                 160 


Asn Ala Gln Val Ile His Gln Leu Gly Pro Gly Leu Arg Ser Lys Met 
                165                 170                 175     


Ala Ile Gln Thr Gln Gln Ser Lys Phe Val Asn Trp Gln Val Asp Gly 
            180                 185                 190         


Glu Tyr Arg Gly Ser Asp Phe Thr Ala Ala Val Thr Leu Gly Asn Pro 
        195                 200                 205             


Asp Val Leu Val Gly Ser Gly Ile Leu Val Ala His Tyr Leu Gln Ser 
    210                 215                 220                 


Ile Thr Pro Cys Leu Ala Leu Gly Gly Glu Leu Val Tyr His Arg Arg 
225                 230                 235                 240 


Pro Gly Glu Glu Gly Thr Val Met Ser Leu Ala Gly Lys Tyr Thr Leu 
                245                 250                 255     


Asn Asn Trp Leu Ala Thr Val Thr Leu Gly Gln Ala Gly Met His Ala 
            260                 265                 270         


Thr Tyr Tyr His Lys Ala Ser Asp Gln Leu Gln Val Gly Val Glu Phe 
        275                 280                 285             


Glu Ala Ser Thr Arg Met Gln Asp Thr Ser Val Ser Phe Gly Tyr Gln 
    290                 295                 300                 


Leu Asp Leu Pro Lys Ala Asn Leu Leu Phe Lys Gly Ser Val Asp Ser 
305                 310                 315                 320 


Asn Trp Ile Val Gly Ala Thr Leu Glu Lys Lys Leu Pro Pro Leu Pro 
                325                 330                 335     


Leu Thr Leu Ala Leu Gly Ala Phe Leu Asn His Arg Lys Asn Lys Phe 
            340                 345                 350         


Gln Cys Gly Phe Gly Leu Thr Ile Gly 
        355                 360     


<210>  5
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Met Ser Gly Gly Gly Asp Val Val Cys Thr Gly Trp Leu Arg Lys Ser 
1               5                   10                  15      


Pro Pro Glu Lys Lys Leu Arg Arg Tyr Ala Trp Lys Lys Arg Trp Phe 
            20                  25                  30          


Ile Leu Arg Ser Gly Arg Met Ser Gly Asp Pro Asp Val Leu Glu Tyr 
        35                  40                  45              


Tyr Lys Asn Asp His Ser Lys Lys Pro Leu Arg Ile Ile Asn Leu Asn 
    50                  55                  60                  


Phe Cys Glu Gln Val Asp Ala Gly Leu Thr Phe Asn Lys Lys Glu Leu 
65                  70                  75                  80  


Gln Asp Ser Phe Val Phe Asp Ile Lys Thr Ser Glu Arg Thr Phe Tyr 
                85                  90                  95      


Leu Val Ala Glu Thr Glu Glu Asp Met Asn Lys Trp Val Gln Ser Ile 
            100                 105                 110         


Cys Gln Ile Cys Gly Phe Asn Gln Ala Glu Glu Ser Thr Asp Ser Leu 
        115                 120                 125             


Arg Asn Val Ser Ser Ala Gly His Gly Pro Arg Ser Ser Pro Ala Glu 
    130                 135                 140                 


Leu Ser Ser Ser Ser Gln His Leu Leu Arg Glu Arg Lys Ser Ser Ala 
145                 150                 155                 160 


Pro Ser His Ser Ser Gln Pro Thr Leu Phe Thr Phe Glu Pro Pro Val 
                165                 170                 175     


Ser Asn His Met Gln Pro Thr Leu Ser Thr Ser Ala Pro Gln Glu Tyr 
            180                 185                 190         


Leu Tyr Leu His Gln Cys Ile Ser Arg Arg Ala Glu Asn Ala Arg Ser 
        195                 200                 205             


Ala Ser Phe Ser Gln Gly Thr Arg Ala Ser Phe Leu Met Arg Ser Asp 
    210                 215                 220                 


Thr Ala Val Gln Lys Leu Ala Gln Gly Asn Gly His Cys Val Asn Gly 
225                 230                 235                 240 


Ile Ser Gly Gln Val His Gly Phe Tyr Ser Leu Pro Lys Pro Ser Arg 
                245                 250                 255     


His Asn Thr Glu Phe Arg Asp Ser Thr Tyr Asp Leu Pro Arg Ser Leu 
            260                 265                 270         


Ala Ser His Gly His Thr Lys Gly Ser Leu Thr Gly Ser Glu Thr Asp 
        275                 280                 285             


Asn Glu Asp Val Tyr Thr Phe Lys Thr Pro Ser Asn Thr Leu Cys Arg 
    290                 295                 300                 


Glu Phe Gly Asp Leu Leu Val Asp Asn Met Asp Val Pro Ala Thr Pro 
305                 310                 315                 320 


Leu Ser Ala Tyr Gln Ile Pro Arg Thr Phe Thr Leu Asp Lys Asn His 
                325                 330                 335     


Asn Ala Met Thr Val Ala Thr Pro Gly Asp Ser Ala Ile Ala Pro Pro 
            340                 345                 350         


Pro Arg Pro Pro Lys Pro Ser Gln Ala Glu Thr Pro Arg Trp Gly Ser 
        355                 360                 365             


Pro Gln Gln Arg Pro Pro Ile Ser Glu Asn Ser Arg Ser Val Ala Ala 
    370                 375                 380                 


Thr Ile Pro Arg Arg Asn Thr Leu Pro Ala Met Asp Asn Ser Arg Leu 
385                 390                 395                 400 


His Arg Ala Ser Ser Cys Glu Thr Tyr Glu Tyr Pro Gln Arg Gly Gly 
                405                 410                 415     


Glu Ser Ala Gly Arg Ser Ala Glu Ser Met Ser Asp Gly Val Gly Ser 
            420                 425                 430         


Phe Leu Pro Gly Lys Met Ile Val Gly Arg Ser Asp Ser Thr Asn Ser 
        435                 440                 445             


Glu Asp Asn Tyr Val Pro Met Asn Pro Gly Ser Ser Thr Leu Leu Ala 
    450                 455                 460                 


Met Glu Arg Ala Gly Asp Asn Ser Gln Ser Val Tyr Ile Pro Met Ser 
465                 470                 475                 480 


Pro Gly Ala His His Phe Asp Ser Leu Gly Tyr Pro Ser Thr Thr Leu 
                485                 490                 495     


Pro Val His Arg Gly Pro Ser Arg Gly Ser Glu Ile Gln Pro Pro Pro 
            500                 505                 510         


Val Asn Arg Asn Leu Lys Pro Asp Arg Lys Ala Lys Pro Thr Pro Leu 
        515                 520                 525             


Asp Leu Arg Asn Asn Thr Val Ile Asp Glu Leu Pro Phe Lys Ser Pro 
    530                 535                 540                 


Ile Thr Lys Ser Trp Ser Arg Ala Asn His Thr Phe Asn Ser Ser Ser 
545                 550                 555                 560 


Ser Gln Tyr Cys Arg Pro Ile Ser Thr Gln Ser Ile Thr Ser Thr Asp 
                565                 570                 575     


Ser Gly Asp Ser Glu Glu Asn Tyr Val Pro Met Gln Asn Pro Val Ser 
            580                 585                 590         


Ala Ser Pro Val Pro Ser Gly Thr Asn Ser Pro Ala Pro Lys Lys Ser 
        595                 600                 605             


Thr Gly Ser Val Asp Tyr Leu Ala Leu Asp Phe Gln Pro Ser Ser Pro 
    610                 615                 620                 


Ser Pro His Arg Lys Pro Ser Thr Ser Ser Val Thr Ser Asp Glu Lys 
625                 630                 635                 640 


Val Asp Tyr Val Gln Val Asp Lys Glu Lys Thr Gln Ala Leu Gln Asn 
                645                 650                 655     


Thr Met Gln Glu Trp Thr Asp Val Arg Gln Ser Ser Glu Pro Ser Lys 
            660                 665                 670         


Gly Ala Lys Leu 
        675     


<210>  6
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 
            20                  25                  30          


Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 
        35                  40                  45              


Arg Glu Leu Ile Ser Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 
    50                  55                  60                  


Arg Glu Trp Phe Ser Glu Thr Phe Gln Lys Val Lys Glu Lys Leu Lys 
65                  70                  75                  80  


Ile Asp Ser 
            


<210>  7
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Met Ala Glu Leu Gln Gln Leu Gln Glu Phe Glu Ile Pro Thr Gly Arg 
1               5                   10                  15      


Glu Ala Leu Arg Gly Asn His Ser Ala Leu Leu Arg Val Ala Asp Tyr 
            20                  25                  30          


Cys Glu Asp Asn Tyr Val Gln Ala Thr Asp Lys Arg Lys Ala Leu Glu 
        35                  40                  45              


Glu Thr Met Ala Phe Thr Thr Gln Ala Leu Ala Ser Val Ala Tyr Gln 
    50                  55                  60                  


Val Gly Asn Leu Ala Gly His Thr Leu Arg Met Leu Asp Leu Gln Gly 
65                  70                  75                  80  


Ala Ala Leu Arg Gln Val Glu Ala Arg Val Ser Thr Leu Gly Gln Met 
                85                  90                  95      


Val Asn Met His Met Glu Lys Val Ala Arg Arg Glu Ile Gly Thr Leu 
            100                 105                 110         


Ala Thr Val Gln Arg Leu Pro Pro Gly Gln Lys Val Ile Ala Pro Glu 
        115                 120                 125             


Asn Leu Pro Pro Leu Thr Pro Tyr Cys Arg Arg Pro Leu Asn Phe Gly 
    130                 135                 140                 


Cys Leu Asp Asp Ile Gly His Gly Ile Lys Asp Leu Ser Thr Gln Leu 
145                 150                 155                 160 


Ser Arg Thr Gly Thr Leu Ser Arg Lys Ser Ile Lys Ala Pro Ala Thr 
                165                 170                 175     


Pro Ala Ser Ala Thr Leu Gly Arg Pro Pro Arg Ile Pro Glu Pro Val 
            180                 185                 190         


His Leu Pro Val Val Pro Asp Gly Arg Leu Ser Ala Ala Ser Ser Ala 
        195                 200                 205             


Phe Ser Leu Ala Ser Ala Gly Ser Ala Glu Gly Val Gly Gly Ala Pro 
    210                 215                 220                 


Thr Pro Lys Gly Gln Ala Ala Pro Pro Ala Pro Pro Leu Pro Ser Ser 
225                 230                 235                 240 


Leu Asp Pro Pro Pro Pro Pro Ala Ala Val Glu Val Phe Gln Arg Pro 
                245                 250                 255     


Pro Thr Leu Glu Glu Leu Ser Pro Pro Pro Pro Asp Glu Glu Leu Pro 
            260                 265                 270         


Leu Pro Leu Asp Leu Pro Pro Pro Pro Pro Leu Asp Gly Asp Glu Leu 
        275                 280                 285             


Gly Leu Pro Pro Pro Pro Pro Gly Phe Gly Pro Asp Glu Pro Ser Trp 
    290                 295                 300                 


Val Pro Ala Ser Tyr Leu Glu Lys Val Val Thr Leu Tyr Pro Tyr Thr 
305                 310                 315                 320 


Ser Gln Lys Asp Asn Glu Leu Ser Phe Ser Glu Gly Thr Val Ile Cys 
                325                 330                 335     


Val Thr Arg Arg Tyr Ser Asp Gly Trp Cys Glu Gly Val Ser Ser Glu 
            340                 345                 350         


Gly Thr Gly Phe Phe Pro Gly Asn Tyr Val Glu Pro Ser Cys 
        355                 360                 365     


<210>  8
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Ala Glu Met Gly Ser Lys Gly Val Thr Ala Gly Lys Ile Ala Ser 
1               5                   10                  15      


Asn Val Gln Lys Lys Leu Thr Arg Ala Gln Glu Lys Val Leu Gln Lys 
            20                  25                  30          


Leu Gly Lys Ala Asp Glu Thr Lys Asp Glu Gln Phe Glu Gln Cys Val 
        35                  40                  45              


Gln Asn Phe Asn Lys Gln Leu Thr Glu Gly Thr Arg Leu Gln Lys Asp 
    50                  55                  60                  


Leu Arg Thr Tyr Leu Ala Ser Val Lys Ala Met His Glu Ala Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Glu Cys Leu Gln Glu Val Tyr Glu Pro Asp Trp Pro Gly 
                85                  90                  95      


Arg Asp Glu Ala Asn Lys Ile Ala Glu Asn Asn Asp Leu Leu Trp Met 
            100                 105                 110         


Asp Tyr His Gln Lys Leu Val Asp Gln Ala Leu Leu Thr Met Asp Thr 
        115                 120                 125             


Tyr Leu Gly Gln Phe Pro Asp Ile Lys Ser Arg Ile Ala Lys Arg Gly 
    130                 135                 140                 


Arg Lys Leu Val Asp Tyr Asp Ser Ala Arg His His Tyr Glu Ser Leu 
145                 150                 155                 160 


Gln Thr Ala Lys Lys Lys Asp Glu Ala Lys Ile Ala Lys Pro Val Ser 
                165                 170                 175     


Leu Leu Glu Lys Ala Ala Pro Gln Trp Cys Gln Gly Lys Leu Gln Ala 
            180                 185                 190         


His Leu Val Ala Gln Thr Asn Leu Leu Arg Asn Gln Ala Glu Glu Glu 
        195                 200                 205             


Leu Ile Lys Ala Gln Lys Val Phe Glu Glu Met Asn Val Asp Leu Gln 
    210                 215                 220                 


Glu Glu Leu Pro Ser Leu Trp Asn Ser Arg Val Gly Phe Tyr Val Asn 
225                 230                 235                 240 


Thr Phe Gln Ser Ile Ala Gly Leu Glu Glu Asn Phe His Lys Glu Met 
                245                 250                 255     


Ser Lys Leu Asn Gln Asn Leu Asn Asp Val Leu Val Gly Leu Glu Lys 
            260                 265                 270         


Gln His Gly Ser Asn Thr Phe Thr Val Lys Ala Gln Pro Ser Asp Asn 
        275                 280                 285             


Ala Pro Ala Lys Gly Asn Lys Ser Pro Ser Pro Pro Asp Gly Ser Pro 
    290                 295                 300                 


Ala Ala Thr Pro Glu Ile Arg Val Asn His Glu Pro Glu Pro Ala Gly 
305                 310                 315                 320 


Gly Ala Thr Pro Gly Ala Thr Leu Pro Lys Ser Pro Ser Gln Leu Arg 
                325                 330                 335     


Lys Gly Pro Pro Val Pro Pro Pro Pro Lys His Thr Pro Ser Lys Glu 
            340                 345                 350         


Val Lys Gln Glu Gln Ile Leu Ser Leu Phe Glu Asp Thr Phe Val Pro 
        355                 360                 365             


Glu Ile Ser Val Thr Thr Pro Ser Gln Phe Glu Ala Pro Gly Pro Phe 
    370                 375                 380                 


Ser Glu Gln Ala Ser Leu Leu Asp Leu Asp Phe Asp Pro Leu Pro Pro 
385                 390                 395                 400 


Val Thr Ser Pro Val Lys Ala Pro Thr Pro Ser Gly Gln Ser Ile Pro 
                405                 410                 415     


Trp Asp Leu Trp Glu Pro Thr Glu Ser Pro Ala Gly Ser Leu Pro Ser 
            420                 425                 430         


Gly Glu Pro Ser Ala Ala Glu Gly Thr Phe Ala Val Ser Trp Pro Ser 
        435                 440                 445             


Gln Thr Ala Glu Pro Gly Pro Ala Gln Pro Ala Glu Ala Ser Glu Val 
    450                 455                 460                 


Ala Gly Gly Thr Gln Pro Ala Ala Gly Ala Gln Glu Pro Gly Glu Thr 
465                 470                 475                 480 


Ala Ala Ser Glu Ala Ala Ser Ser Ser Leu Pro Ala Val Val Val Glu 
                485                 490                 495     


Thr Phe Pro Ala Thr Val Asn Gly Thr Val Glu Gly Gly Ser Gly Ala 
            500                 505                 510         


Gly Arg Leu Asp Leu Pro Pro Gly Phe Met Phe Lys Val Gln Ala Gln 
        515                 520                 525             


His Asp Tyr Thr Ala Thr Asp Thr Asp Glu Leu Gln Leu Lys Ala Gly 
    530                 535                 540                 


Asp Val Val Leu Val Ile Pro Phe Gln Asn Pro Glu Glu Gln Asp Glu 
545                 550                 555                 560 


Gly Trp Leu Met Gly Val Lys Glu Ser Asp Trp Asn Gln His Lys Glu 
                565                 570                 575     


Leu Glu Lys Cys Arg Gly Val Phe Pro Glu Asn Phe Thr Glu Arg Val 
            580                 585                 590         


Pro 
    


<210>  9
<211>  2039
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Thr 
    1385                 1390                 1395             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Thr Ile Pro  Ile Asn Asp 
    1400                 1405                 1410             


Phe Glu  Phe Pro Val Gly Thr  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1415                 1420                 1425             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1430                 1435                 1440             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1445                 1450                 1455             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Thr Asp 
    1460                 1465                 1470             


Thr Gln  Phe Gly Ser Thr Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1475                 1480                 1485             


Arg Leu  Ile Gly Ser Pro Ser  Thr Thr Cys Leu Val  Ser Gly Asn 
    1490                 1495                 1500             


Asn Val  Thr Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1505                 1510                 1515             


Cys Glu  Pro Pro Pro Thr Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1520                 1525                 1530             


Asn Arg  Thr Ser Phe His Asn  Gly Thr Val Val Thr  Tyr Gln Cys 
    1535                 1540                 1545             


His Thr  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    1550                 1555                 1560             


Arg Ser  Ile Tyr Cys Thr Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    1565                 1570                 1575             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Thr Asn Lys  Cys Thr Ala 
    1580                 1585                 1590             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    1595                 1600                 1605             


Phe Ser  Leu Thr Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    1610                 1615                 1620             


Val Met  Val Gly Ser His Thr  Val Gln Cys Gln Thr  Asn Gly Arg 
    1625                 1630                 1635             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    1640                 1645                 1650             


Pro Glu  Ile Leu His Gly Glu  His Thr Leu Ser His  Gln Asp Asn 
    1655                 1660                 1665             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    1670                 1675                 1680             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Thr Pro  Gln Gly Asp 
    1685                 1690                 1695             


Trp Ser  Pro Glu Ala Pro Arg  Cys Thr Val Lys Ser  Cys Asp Asp 
    1700                 1705                 1710             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    1715                 1720                 1725             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    1730                 1735                 1740             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    1745                 1750                 1755             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    1760                 1765                 1770             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Thr Gly Thr 
    1775                 1780                 1785             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    1790                 1795                 1800             


Asp Thr  His Pro Asp Arg Gly  Met Thr Phe Asn Leu  Ile Gly Glu 
    1805                 1810                 1815             


Ser Ser  Ile Arg Cys Thr Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    1820                 1825                 1830             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    1835                 1840                 1845             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    1850                 1855                 1860             


Val Ser  Leu Tyr Leu Pro Gly  Met Thr Ile Ser Tyr  Ile Cys Asp 
    1865                 1870                 1875             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Thr Asp 
    1880                 1885                 1890             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    1895                 1900                 1905             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    1910                 1915                 1920             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Thr  Leu Lys Cys 
    1925                 1930                 1935             


Glu Asp  Gly Tyr Thr Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    1940                 1945                 1950             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Thr Ser Arg 
    1955                 1960                 1965             


Thr His  Asp Ala Leu Ile Val  Gly Thr Leu Ser Gly  Thr Ile Phe 
    1970                 1975                 1980             


Phe Ile  Leu Leu Ile Ile Phe  Leu Ser Trp Ile Ile  Leu Lys His 
    1985                 1990                 1995             


Arg Lys  Gly Asn Asn Ala His  Glu Asn Pro Lys Glu  Val Ala Ile 
    2000                 2005                 2010             


His Leu  His Ser Gln Gly Gly  Ser Ser Val His Pro  Arg Thr Leu 
    2015                 2020                 2025             


Gln Thr  Asn Glu Glu Asn Ser  Arg Val Leu Pro 
    2030                 2035                 


<210>  10
<211>  2146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Ala Phe Trp Thr Gln Leu Met Leu Leu Leu Trp Lys Asn Phe Met 
1               5                   10                  15      


Tyr Arg Arg Arg Gln Pro Val Gln Leu Leu Val Glu Leu Leu Trp Pro 
            20                  25                  30          


Leu Phe Leu Phe Phe Ile Leu Val Ala Val Arg His Ser His Pro Pro 
        35                  40                  45              


Leu Glu His His Glu Cys His Phe Pro Asn Lys Pro Leu Pro Ser Ala 
    50                  55                  60                  


Gly Thr Val Pro Trp Leu Gln Gly Leu Ile Cys Asn Val Asn Asn Thr 
65                  70                  75                  80  


Cys Phe Pro Gln Leu Thr Pro Gly Glu Glu Pro Gly Arg Leu Ser Asn 
                85                  90                  95      


Phe Asn Asp Ser Leu Val Ser Arg Leu Leu Ala Asp Ala Arg Thr Val 
            100                 105                 110         


Leu Gly Gly Ala Ser Ala His Arg Thr Leu Ala Gly Leu Gly Lys Leu 
        115                 120                 125             


Ile Ala Thr Leu Arg Ala Ala Arg Ser Thr Ala Gln Pro Gln Pro Thr 
    130                 135                 140                 


Lys Gln Ser Pro Leu Glu Pro Pro Met Leu Asp Val Ala Glu Leu Leu 
145                 150                 155                 160 


Thr Ser Leu Leu Arg Thr Glu Ser Leu Gly Leu Ala Leu Gly Gln Ala 
                165                 170                 175     


Gln Glu Pro Leu His Ser Leu Leu Glu Ala Ala Glu Asp Leu Ala Gln 
            180                 185                 190         


Glu Leu Leu Ala Leu Arg Ser Leu Val Glu Leu Arg Ala Leu Leu Gln 
        195                 200                 205             


Arg Pro Arg Gly Thr Ser Gly Pro Leu Glu Leu Leu Ser Glu Ala Leu 
    210                 215                 220                 


Cys Ser Val Arg Gly Pro Ser Ser Thr Val Gly Pro Ser Leu Asn Trp 
225                 230                 235                 240 


Tyr Glu Ala Ser Asp Leu Met Glu Leu Val Gly Gln Glu Pro Glu Ser 
                245                 250                 255     


Ala Leu Pro Asp Ser Ser Leu Ser Pro Ala Cys Ser Glu Leu Ile Gly 
            260                 265                 270         


Ala Leu Asp Ser His Pro Leu Ser Arg Leu Leu Trp Arg Arg Leu Lys 
        275                 280                 285             


Pro Leu Ile Leu Gly Lys Leu Leu Phe Ala Pro Asp Thr Pro Phe Thr 
    290                 295                 300                 


Arg Lys Leu Met Ala Gln Val Asn Arg Thr Phe Glu Glu Leu Thr Leu 
305                 310                 315                 320 


Leu Arg Asp Val Arg Glu Val Trp Glu Met Leu Gly Pro Arg Ile Phe 
                325                 330                 335     


Thr Phe Met Asn Asp Ser Ser Asn Val Ala Met Leu Gln Arg Leu Leu 
            340                 345                 350         


Gln Met Gln Asp Glu Gly Arg Arg Gln Pro Arg Pro Gly Gly Arg Asp 
        355                 360                 365             


His Met Glu Ala Leu Arg Ser Phe Leu Asp Pro Gly Ser Gly Gly Tyr 
    370                 375                 380                 


Ser Trp Gln Asp Ala His Ala Asp Val Gly His Leu Val Gly Thr Leu 
385                 390                 395                 400 


Gly Arg Val Thr Glu Cys Leu Ser Leu Asp Lys Leu Glu Ala Ala Pro 
                405                 410                 415     


Ser Glu Ala Ala Leu Val Ser Arg Ala Leu Gln Leu Leu Ala Glu His 
            420                 425                 430         


Arg Phe Trp Ala Gly Val Val Phe Leu Gly Pro Glu Asp Ser Ser Asp 
        435                 440                 445             


Pro Thr Glu His Pro Thr Pro Asp Leu Gly Pro Gly His Val Arg Ile 
    450                 455                 460                 


Lys Ile Arg Met Asp Ile Asp Val Val Thr Arg Thr Asn Lys Ile Arg 
465                 470                 475                 480 


Asp Arg Phe Trp Asp Pro Gly Pro Ala Ala Asp Pro Leu Thr Asp Leu 
                485                 490                 495     


Arg Tyr Val Trp Gly Gly Phe Val Tyr Leu Gln Asp Leu Val Glu Arg 
            500                 505                 510         


Ala Ala Val Arg Val Leu Ser Gly Ala Asn Pro Arg Ala Gly Leu Tyr 
        515                 520                 525             


Leu Gln Gln Met Pro Tyr Pro Cys Tyr Val Asp Asp Val Phe Leu Arg 
    530                 535                 540                 


Val Leu Ser Arg Ser Leu Pro Leu Phe Leu Thr Leu Ala Trp Ile Tyr 
545                 550                 555                 560 


Ser Val Thr Leu Thr Val Lys Ala Val Val Arg Glu Lys Glu Thr Arg 
                565                 570                 575     


Leu Arg Asp Thr Met Arg Ala Met Gly Leu Ser Arg Ala Val Leu Trp 
            580                 585                 590         


Leu Gly Trp Phe Leu Ser Cys Leu Gly Pro Phe Leu Leu Ser Ala Ala 
        595                 600                 605             


Leu Leu Val Leu Val Leu Lys Leu Gly Asp Ile Leu Pro Tyr Ser His 
    610                 615                 620                 


Pro Gly Val Val Phe Leu Phe Leu Ala Ala Phe Ala Val Ala Thr Val 
625                 630                 635                 640 


Thr Gln Ser Phe Leu Leu Ser Ala Phe Phe Ser Arg Ala Asn Leu Ala 
                645                 650                 655     


Ala Ala Cys Gly Gly Leu Ala Tyr Phe Ser Leu Tyr Leu Pro Tyr Val 
            660                 665                 670         


Leu Cys Val Ala Trp Arg Asp Arg Leu Pro Ala Gly Gly Arg Val Ala 
        675                 680                 685             


Ala Ser Leu Leu Ser Pro Val Ala Phe Gly Phe Gly Cys Glu Ser Leu 
    690                 695                 700                 


Ala Leu Leu Glu Glu Gln Gly Glu Gly Ala Gln Trp His Asn Val Gly 
705                 710                 715                 720 


Thr Arg Pro Thr Ala Asp Val Phe Ser Leu Ala Gln Val Ser Gly Leu 
                725                 730                 735     


Leu Leu Leu Asp Ala Ala Leu Tyr Gly Leu Ala Thr Trp Tyr Leu Glu 
            740                 745                 750         


Ala Val Cys Pro Gly Gln Tyr Gly Ile Pro Glu Pro Trp Asn Phe Pro 
        755                 760                 765             


Phe Arg Arg Ser Tyr Trp Cys Gly Pro Arg Pro Pro Lys Ser Pro Ala 
    770                 775                 780                 


Pro Cys Pro Thr Pro Leu Asp Pro Lys Val Leu Val Glu Glu Ala Pro 
785                 790                 795                 800 


Pro Gly Leu Ser Pro Gly Val Ser Val Arg Ser Leu Glu Lys Arg Phe 
                805                 810                 815     


Pro Gly Ser Pro Gln Pro Ala Leu Arg Gly Leu Ser Leu Asp Phe Tyr 
            820                 825                 830         


Gln Gly His Ile Thr Ala Phe Leu Gly His Asn Gly Ala Gly Lys Thr 
        835                 840                 845             


Thr Thr Leu Ser Ile Leu Ser Gly Leu Phe Pro Pro Ser Gly Gly Ser 
    850                 855                 860                 


Ala Phe Ile Leu Gly His Asp Val Arg Ser Ser Met Ala Ala Ile Arg 
865                 870                 875                 880 


Pro His Leu Gly Val Cys Pro Gln Tyr Asn Val Leu Phe Asp Met Leu 
                885                 890                 895     


Thr Val Asp Glu His Val Trp Phe Tyr Gly Arg Leu Lys Gly Leu Ser 
            900                 905                 910         


Ala Ala Val Val Gly Pro Glu Gln Asp Arg Leu Leu Gln Asp Val Gly 
        915                 920                 925             


Leu Val Ser Lys Gln Ser Val Gln Thr Arg His Leu Ser Gly Gly Met 
    930                 935                 940                 


Gln Arg Lys Leu Ser Val Ala Ile Ala Phe Val Gly Gly Ser Gln Val 
945                 950                 955                 960 


Val Ile Leu Asp Glu Pro Thr Ala Gly Val Asp Pro Ala Ser Arg Arg 
                965                 970                 975     


Gly Ile Trp Glu Leu Leu Leu Lys Tyr Arg Glu Gly Arg Thr Leu Ile 
            980                 985                 990         


Leu Ser Thr His His Leu Asp Glu  Ala Glu Leu Leu Gly  Asp Arg Val 
        995                 1000                 1005             


Ala Val  Val Ala Gly Gly Arg  Leu Cys Cys Cys Gly  Ser Pro Leu 
    1010                 1015                 1020             


Phe Leu  Arg Arg His Leu Gly  Ser Gly Tyr Tyr Leu  Thr Leu Val 
    1025                 1030                 1035             


Lys Ala  Arg Leu Pro Leu Thr  Thr Asn Glu Lys Ala  Asp Thr Asp 
    1040                 1045                 1050             


Met Glu  Gly Ser Val Asp Thr  Arg Gln Glu Lys Lys  Asn Gly Ser 
    1055                 1060                 1065             


Gln Gly  Ser Arg Val Gly Thr  Pro Gln Leu Leu Ala  Leu Val Gln 
    1070                 1075                 1080             


His Trp  Val Pro Gly Ala Arg  Leu Val Glu Glu Leu  Pro His Glu 
    1085                 1090                 1095             


Leu Val  Leu Val Leu Pro Tyr  Thr Gly Ala His Asp  Gly Ser Phe 
    1100                 1105                 1110             


Ala Thr  Leu Phe Arg Glu Leu  Asp Thr Arg Leu Ala  Glu Leu Arg 
    1115                 1120                 1125             


Leu Thr  Gly Tyr Gly Ile Ser  Asp Thr Ser Leu Glu  Glu Ile Phe 
    1130                 1135                 1140             


Leu Lys  Val Val Glu Glu Cys  Ala Ala Asp Thr Asp  Met Glu Asp 
    1145                 1150                 1155             


Gly Ser  Cys Gly Gln His Leu  Cys Thr Gly Ile Ala  Gly Leu Asp 
    1160                 1165                 1170             


Val Thr  Leu Arg Leu Lys Met  Pro Pro Gln Glu Thr  Ala Leu Glu 
    1175                 1180                 1185             


Asn Gly  Glu Pro Ala Gly Ser  Ala Pro Glu Thr Asp  Gln Gly Ser 
    1190                 1195                 1200             


Gly Pro  Asp Ala Val Gly Arg  Val Gln Gly Trp Ala  Leu Thr Arg 
    1205                 1210                 1215             


Gln Gln  Leu Gln Ala Leu Leu  Leu Lys Arg Phe Leu  Leu Ala Arg 
    1220                 1225                 1230             


Arg Ser  Arg Arg Gly Leu Phe  Ala Gln Ile Val Leu  Pro Ala Leu 
    1235                 1240                 1245             


Phe Val  Gly Leu Ala Leu Val  Phe Ser Leu Ile Val  Pro Pro Phe 
    1250                 1255                 1260             


Gly His  Tyr Pro Ala Leu Arg  Leu Ser Pro Thr Met  Tyr Gly Ala 
    1265                 1270                 1275             


Gln Val  Ser Phe Phe Ser Glu  Asp Ala Pro Gly Asp  Pro Gly Arg 
    1280                 1285                 1290             


Ala Arg  Leu Leu Glu Ala Leu  Leu Gln Glu Ala Gly  Leu Glu Glu 
    1295                 1300                 1305             


Pro Pro  Val Gln His Ser Ser  His Arg Phe Ser Ala  Pro Glu Val 
    1310                 1315                 1320             


Pro Ala  Glu Val Ala Lys Val  Leu Ala Ser Gly Asn  Trp Thr Pro 
    1325                 1330                 1335             


Glu Ser  Pro Ser Pro Ala Cys  Gln Cys Ser Arg Pro  Gly Ala Arg 
    1340                 1345                 1350             


Arg Leu  Leu Pro Asp Cys Pro  Ala Ala Ala Gly Gly  Pro Pro Pro 
    1355                 1360                 1365             


Pro Gln  Ala Val Thr Gly Ser  Gly Glu Val Val Gln  Asn Leu Thr 
    1370                 1375                 1380             


Gly Arg  Asn Leu Ser Asp Phe  Leu Val Lys Thr Tyr  Pro Arg Leu 
    1385                 1390                 1395             


Val Arg  Gln Gly Leu Lys Thr  Lys Lys Trp Val Asn  Glu Val Arg 
    1400                 1405                 1410             


Tyr Gly  Gly Phe Ser Leu Gly  Gly Arg Asp Pro Gly  Leu Pro Ser 
    1415                 1420                 1425             


Gly Gln  Glu Leu Gly Arg Ser  Val Glu Glu Leu Trp  Ala Leu Leu 
    1430                 1435                 1440             


Ser Pro  Leu Pro Gly Gly Ala  Leu Asp Arg Val Leu  Lys Asn Leu 
    1445                 1450                 1455             


Thr Ala  Trp Ala His Ser Leu  Asp Ala Gln Asp Ser  Leu Lys Ile 
    1460                 1465                 1470             


Trp Phe  Asn Asn Lys Gly Trp  His Ser Met Val Ala  Phe Val Asn 
    1475                 1480                 1485             


Arg Ala  Ser Asn Ala Ile Leu  Arg Ala His Leu Pro  Pro Gly Pro 
    1490                 1495                 1500             


Ala Arg  His Ala His Ser Ile  Thr Thr Leu Asn His  Pro Leu Asn 
    1505                 1510                 1515             


Leu Thr  Lys Glu Gln Leu Ser  Glu Gly Ala Leu Met  Ala Ser Ser 
    1520                 1525                 1530             


Val Asp  Val Leu Val Ser Ile  Cys Val Val Phe Ala  Met Ser Phe 
    1535                 1540                 1545             


Val Pro  Ala Ser Phe Thr Leu  Val Leu Ile Glu Glu  Arg Val Thr 
    1550                 1555                 1560             


Arg Ala  Lys His Leu Gln Leu  Met Gly Gly Leu Ser  Pro Thr Leu 
    1565                 1570                 1575             


Tyr Trp  Leu Gly Asn Phe Leu  Trp Asp Met Cys Asn  Tyr Leu Val 
    1580                 1585                 1590             


Pro Ala  Cys Ile Val Val Leu  Ile Phe Leu Ala Phe  Gln Gln Arg 
    1595                 1600                 1605             


Ala Tyr  Val Ala Pro Ala Asn  Leu Pro Ala Leu Leu  Leu Leu Leu 
    1610                 1615                 1620             


Leu Leu  Tyr Gly Trp Ser Ile  Thr Pro Leu Met Tyr  Pro Ala Ser 
    1625                 1630                 1635             


Phe Phe  Phe Ser Val Pro Ser  Thr Ala Tyr Val Val  Leu Thr Cys 
    1640                 1645                 1650             


Ile Asn  Leu Phe Ile Gly Ile  Asn Gly Ser Met Ala  Thr Phe Val 
    1655                 1660                 1665             


Leu Glu  Leu Phe Ser Asp Gln  Lys Leu Gln Glu Val  Ser Arg Ile 
    1670                 1675                 1680             


Leu Lys  Gln Val Phe Leu Ile  Phe Pro His Phe Cys  Leu Gly Arg 
    1685                 1690                 1695             


Gly Leu  Ile Asp Met Val Arg  Asn Gln Ala Met Ala  Asp Ala Phe 
    1700                 1705                 1710             


Glu Arg  Leu Gly Asp Arg Gln  Phe Gln Ser Pro Leu  Arg Trp Glu 
    1715                 1720                 1725             


Val Val  Gly Lys Asn Leu Leu  Ala Met Val Ile Gln  Gly Pro Leu 
    1730                 1735                 1740             


Phe Leu  Leu Phe Thr Leu Leu  Leu Gln His Arg Ser  Gln Leu Leu 
    1745                 1750                 1755             


Pro Gln  Pro Arg Val Arg Ser  Leu Pro Leu Leu Gly  Glu Glu Asp 
    1760                 1765                 1770             


Glu Asp  Val Ala Arg Glu Arg  Glu Arg Val Val Gln  Gly Ala Thr 
    1775                 1780                 1785             


Gln Gly  Asp Val Leu Val Leu  Arg Asn Leu Thr Lys  Val Tyr Arg 
    1790                 1795                 1800             


Gly Gln  Arg Met Pro Ala Val  Asp Arg Leu Cys Leu  Gly Ile Pro 
    1805                 1810                 1815             


Pro Gly  Glu Cys Phe Gly Leu  Leu Gly Val Asn Gly  Ala Gly Lys 
    1820                 1825                 1830             


Thr Ser  Thr Phe Arg Met Val  Thr Gly Asp Thr Leu  Ala Ser Arg 
    1835                 1840                 1845             


Gly Glu  Ala Val Leu Ala Gly  His Ser Val Ala Arg  Glu Pro Ser 
    1850                 1855                 1860             


Ala Ala  His Leu Ser Met Gly  Tyr Cys Pro Gln Ser  Asp Ala Ile 
    1865                 1870                 1875             


Phe Glu  Leu Leu Thr Gly Arg  Glu His Leu Glu Leu  Leu Ala Arg 
    1880                 1885                 1890             


Leu Arg  Gly Val Pro Glu Ala  Gln Val Ala Gln Thr  Ala Gly Ser 
    1895                 1900                 1905             


Gly Leu  Ala Arg Leu Gly Leu  Ser Trp Tyr Ala Asp  Arg Pro Ala 
    1910                 1915                 1920             


Gly Thr  Tyr Ser Gly Gly Asn  Lys Arg Lys Leu Ala  Thr Ala Leu 
    1925                 1930                 1935             


Ala Leu  Val Gly Asp Pro Ala  Val Val Phe Leu Asp  Glu Pro Thr 
    1940                 1945                 1950             


Thr Gly  Met Asp Pro Ser Ala  Arg Arg Phe Leu Trp  Asn Ser Leu 
    1955                 1960                 1965             


Leu Ala  Val Val Arg Glu Gly  Arg Ser Val Met Leu  Thr Ser His 
    1970                 1975                 1980             


Ser Met  Glu Glu Cys Glu Ala  Leu Cys Ser Arg Leu  Ala Ile Met 
    1985                 1990                 1995             


Val Asn  Gly Arg Phe Arg Cys  Leu Gly Ser Pro Gln  His Leu Lys 
    2000                 2005                 2010             


Gly Arg  Phe Ala Ala Gly His  Thr Leu Thr Leu Arg  Val Pro Ala 
    2015                 2020                 2025             


Ala Arg  Ser Gln Pro Ala Ala  Ala Phe Val Ala Ala  Glu Phe Pro 
    2030                 2035                 2040             


Gly Ala  Glu Leu Arg Glu Ala  His Gly Gly Arg Leu  Arg Phe Gln 
    2045                 2050                 2055             


Leu Pro  Pro Gly Gly Arg Cys  Ala Leu Ala Arg Val  Phe Gly Glu 
    2060                 2065                 2070             


Leu Ala  Val His Gly Ala Glu  His Gly Val Glu Asp  Phe Ser Val 
    2075                 2080                 2085             


Ser Gln  Thr Met Leu Glu Glu  Val Phe Leu Tyr Phe  Ser Lys Asp 
    2090                 2095                 2100             


Gln Gly  Lys Asp Glu Asp Thr  Glu Glu Gln Lys Glu  Ala Gly Val 
    2105                 2110                 2115             


Gly Val  Asp Pro Ala Pro Gly  Leu Gln His Pro Lys  Arg Val Ser 
    2120                 2125                 2130             


Gln Phe  Leu Asp Asp Pro Ser  Thr Ala Glu Thr Val  Leu 
    2135                 2140                 2145     


<210>  11
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Met Ala Leu Asp Gly Ile Arg Met Pro Asp Gly Cys Tyr Ala Asp Gly 
1               5                   10                  15      


Thr Trp Glu Leu Ser Val His Val Thr Asp Leu Asn Arg Asp Val Thr 
            20                  25                  30          


Leu Arg Val Thr Gly Glu Val His Ile Gly Gly Val Met Leu Lys Leu 
        35                  40                  45              


Val Glu Lys Leu Asp Val Lys Lys Asp Trp Ser Asp His Ala Leu Trp 
    50                  55                  60                  


Trp Glu Lys Lys Arg Thr Trp Leu Leu Lys Thr His Trp Thr Leu Asp 
65                  70                  75                  80  


Lys Tyr Gly Ile Gln Ala Asp Ala Lys Leu Gln Phe Thr Pro Gln His 
                85                  90                  95      


Lys Leu Leu Arg Leu Gln Leu Pro Asn Met Lys Tyr Val Lys Val Lys 
            100                 105                 110         


Val Asn Phe Ser Asp Arg Val Phe Lys Ala Val Ser Asp Ile Cys Lys 
        115                 120                 125             


Thr Phe Asn Ile Arg His Pro Glu Glu Leu Ser Leu Leu Lys Lys Pro 
    130                 135                 140                 


Arg Asp Pro Thr Lys Lys Lys Lys Lys Lys Leu Asp Asp Gln Ser Glu 
145                 150                 155                 160 


Asp Glu Ala Leu Glu Leu Glu Gly Pro Leu Ile Thr Pro Gly Ser Gly 
                165                 170                 175     


Ser Ile Tyr Ser Ser Pro Gly Leu Tyr Ser Lys Thr Met Thr Pro Thr 
            180                 185                 190         


Tyr Asp Ala His Asp Gly Ser Pro Leu Ser Pro Thr Ser Ala Trp Phe 
        195                 200                 205             


Gly Asp Ser Ala Leu Ser Glu Gly Asn Pro Gly Ile Leu Ala Val Ser 
    210                 215                 220                 


Gln Pro Ile Thr Ser Pro Glu Ile Leu Ala Lys Met Phe Lys Pro Gln 
225                 230                 235                 240 


Ala Leu Leu Asp Lys Ala Lys Ile Asn Gln Gly Trp Leu Asp Ser Ser 
                245                 250                 255     


Arg Ser Leu Met Glu Gln Asp Val Lys Glu Asn Glu Ala Leu Leu Leu 
            260                 265                 270         


Arg Phe Lys Tyr Tyr Ser Phe Phe Asp Leu Asn Pro Lys Tyr Asp Ala 
        275                 280                 285             


Ile Arg Ile Asn Gln Leu Tyr Glu Gln Ala Lys Trp Ala Ile Leu Leu 
    290                 295                 300                 


Glu Glu Ile Glu Cys Thr Glu Glu Glu Met Met Met Phe Ala Ala Leu 
305                 310                 315                 320 


Gln Tyr His Ile Asn Lys Leu Ser Ile Met Thr Ser Glu Asn His Leu 
                325                 330                 335     


Asn Asn Ser Asp Lys Glu Val Asp Glu Val Asp Ala Ala Leu Ser Asp 
            340                 345                 350         


Leu Glu Ile Thr Leu Glu Gly Gly Lys Thr Ser Thr Ile Leu Gly Asp 
        355                 360                 365             


Ile Thr Ser Ile Pro Glu Leu Ala Asp Tyr Ile Lys Val Phe Lys Pro 
    370                 375                 380                 


Lys Lys Leu Thr Leu Lys Gly Tyr Lys Gln Tyr Trp Cys Thr Phe Lys 
385                 390                 395                 400 


Asp Thr Ser Ile Ser Cys Tyr Lys Ser Lys Glu Glu Ser Ser Gly Thr 
                405                 410                 415     


Pro Ala His Gln Met Asn Leu Arg Gly Cys Glu Val Thr Pro Asp Val 
            420                 425                 430         


Asn Ile Ser Gly Gln Lys Phe Asn Ile Lys Leu Leu Ile Pro Val Ala 
        435                 440                 445             


Glu Gly Met Asn Glu Ile Trp Leu Arg Cys Asp Asn Glu Lys Gln Tyr 
    450                 455                 460                 


Ala His Trp Met Ala Ala Cys Arg Leu Ala Ser Lys Gly Lys Thr Met 
465                 470                 475                 480 


Ala Asp Ser Ser Tyr Asn Leu Glu Val Gln Asn Ile Leu Ser Phe Leu 
                485                 490                 495     


Lys Met Gln His Leu Asn Pro Asp Pro Gln Leu Ile Pro Glu Gln Ile 
            500                 505                 510         


Thr Thr Asp Ile Thr Pro Glu Cys Leu Val Ser Pro Arg Tyr Leu Lys 
        515                 520                 525             


Lys Tyr Lys Asn Lys Gln Ile Thr Ala Arg Ile Leu Glu Ala His Gln 
    530                 535                 540                 


Asn Val Ala Gln Met Ser Leu Ile Glu Ala Lys Met Arg Phe Ile Gln 
545                 550                 555                 560 


Ala Trp Gln Ser Leu Pro Glu Phe Gly Ile Thr His Phe Ile Ala Arg 
                565                 570                 575     


Phe Gln Gly Gly Lys Lys Glu Glu Leu Ile Gly Ile Ala Tyr Asn Arg 
            580                 585                 590         


Leu Ile Arg Met Asp Ala Ser Thr Gly Asp Ala Ile Lys Thr Trp Arg 
        595                 600                 605             


Phe Ser Asn Met Lys Gln Trp Asn Val Asn Trp Glu Ile Lys Met Val 
    610                 615                 620                 


Thr Val Glu Phe Ala Asp Glu Val Arg Leu Ser Phe Ile Cys Thr Glu 
625                 630                 635                 640 


Val Asp Cys Lys Val Val His Glu Phe Ile Gly Gly Tyr Ile Phe Leu 
                645                 650                 655     


Ser Thr Arg Ala Lys Asp Gln Asn Glu Ser Leu Asp Glu Glu Met Phe 
            660                 665                 670         


Tyr Lys Leu Thr Ser Gly Trp Val 
        675                 680 


<210>  12
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Tyr Met Ala Lys Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Gln Gln Asp Lys Tyr Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu His Arg Asp Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Asp Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Arg Thr Gln Thr Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Ser Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Gln Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Lys Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu His Pro Thr Gly Leu Val Ser 
            260                 265     


<210>  13
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Leu Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  14
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Val Asp Tyr Ile Val Glu Tyr Asp Tyr Asp Ala Val His Asp Asp 
1               5                   10                  15      


Glu Leu Thr Ile Arg Val Gly Glu Ile Ile Arg Asn Val Lys Lys Leu 
            20                  25                  30          


Gln Glu Glu Gly Trp Leu Glu Gly Glu Leu Asn Gly Arg Arg Gly Met 
        35                  40                  45              


Phe Pro Asp Asn Phe Val Lys Glu Ile Lys Arg Glu Thr Glu Phe Lys 
    50                  55                  60                  


Asp Asp Ser Leu Pro Ile Lys Arg Glu Arg His Gly Asn Val Ala Ser 
65                  70                  75                  80  


Leu Val Gln Arg Ile Ser Thr Tyr Gly Leu Pro Ala Gly Gly Ile Gln 
                85                  90                  95      


Pro His Pro Gln Thr Lys Asn Ile Lys Lys Lys Thr Lys Lys Arg Gln 
            100                 105                 110         


Cys Lys Val Leu Phe Glu Tyr Ile Pro Gln Asn Glu Asp Glu Leu Glu 
        115                 120                 125             


Leu Lys Val Gly Asp Ile Ile Asp Ile Asn Glu Glu Val Glu Glu Gly 
    130                 135                 140                 


Trp Trp Ser Gly Thr Leu Asn Asn Lys Leu Gly Leu Phe Pro Ser Asn 
145                 150                 155                 160 


Phe Val Lys Glu Leu Glu Val Thr Asp Asp Gly Glu Thr His Glu Ala 
                165                 170                 175     


Gln Asp Asp Ser Glu Thr Val Leu Ala Gly Pro Thr Ser Pro Ile Pro 
            180                 185                 190         


Ser Leu Gly Asn Val Ser Glu Thr Ala Ser Gly Ser Val Thr Gln Pro 
        195                 200                 205             


Lys Lys Ile Arg Gly Ile Gly Phe Gly Asp Ile Phe Lys Glu Gly Ser 
    210                 215                 220                 


Val Lys Leu Arg Thr Arg Thr Ser Ser Ser Glu Thr Glu Glu Lys Lys 
225                 230                 235                 240 


Pro Glu Lys Pro Leu Ile Leu Gln Ser Leu Gly Pro Lys Thr Gln Ser 
                245                 250                 255     


Val Glu Ile Thr Lys Thr Asp Thr Glu Gly Lys Ile Lys Ala Lys Glu 
            260                 265                 270         


Tyr Cys Arg Thr Leu Phe Ala Tyr Glu Gly Thr Asn Glu Asp Glu Leu 
        275                 280                 285             


Thr Phe Lys Glu Gly Glu Ile Ile His Leu Ile Ser Lys Glu Thr Gly 
    290                 295                 300                 


Glu Ala Gly Trp Trp Arg Gly Glu Leu Asn Gly Lys Glu Gly Val Phe 
305                 310                 315                 320 


Pro Asp Asn Phe Ala Val Gln Ile Asn Glu Leu Asp Lys Asp Phe Pro 
                325                 330                 335     


Lys Pro Lys Lys Pro Pro Pro Pro Ala Lys Ala Pro Ala Pro Lys Pro 
            340                 345                 350         


Glu Leu Ile Ala Ala Glu Lys Lys Tyr Phe Ser Leu Lys Pro Glu Glu 
        355                 360                 365             


Lys Asp Glu Lys Ser Thr Leu Glu Gln Lys Pro Ser Lys Pro Ala Ala 
    370                 375                 380                 


Pro Gln Val Pro Pro Lys Lys Pro Thr Pro Pro Thr Lys Ala Ser Asn 
385                 390                 395                 400 


Leu Leu Arg Ser Ser Gly Thr Val Tyr Pro Lys Arg Pro Glu Lys Pro 
                405                 410                 415     


Val Pro Pro Pro Pro Pro Ile Ala Lys Ile Asn Gly Glu Val Ser Ser 
            420                 425                 430         


Ile Ser Ser Lys Phe Glu Thr Glu Pro Val Ser Lys Leu Lys Leu Asp 
        435                 440                 445             


Ser Glu Gln Leu Pro Leu Arg Pro Lys Ser Val Asp Phe Asp Ser Leu 
    450                 455                 460                 


Thr Val Arg Thr Ser Lys Glu Thr Asp Val Val Asn Phe Asp Asp Ile 
465                 470                 475                 480 


Ala Ser Ser Glu Asn Leu Leu His Leu Thr Ala Asn Arg Pro Lys Met 
                485                 490                 495     


Pro Gly Arg Arg Leu Pro Gly Arg Phe Asn Gly Gly His Ser Pro Thr 
            500                 505                 510         


His Ser Pro Glu Lys Ile Leu Lys Leu Pro Lys Glu Glu Asp Ser Ala 
        515                 520                 525             


Asn Leu Lys Pro Ser Glu Leu Lys Lys Asp Thr Cys Tyr Ser Pro Lys 
    530                 535                 540                 


Pro Ser Val Tyr Leu Ser Thr Pro Ser Ser Ala Ser Lys Ala Asn Thr 
545                 550                 555                 560 


Thr Ala Phe Leu Thr Pro Leu Glu Ile Lys Ala Lys Val Glu Thr Asp 
                565                 570                 575     


Asp Val Lys Lys Asn Ser Leu Asp Glu Leu Arg Ala Gln Ile Ile Glu 
            580                 585                 590         


Leu Leu Cys Ile Val Glu Ala Leu Lys Lys Asp His Gly Lys Glu Leu 
        595                 600                 605             


Glu Lys Leu Arg Lys Asp Leu Glu Glu Glu Lys Thr Met Arg Ser Asn 
    610                 615                 620                 


Leu Glu Met Glu Ile Glu Lys Leu Lys Lys Ala Val Leu Ser Ser 
625                 630                 635                 


<210>  15
<211>  1009
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Met Ser Gly Val Ser Glu Pro Leu Ser Arg Val Lys Leu Gly Thr Leu 
1               5                   10                  15      


Arg Arg Pro Glu Gly Pro Ala Glu Pro Met Val Val Val Pro Val Asp 
            20                  25                  30          


Val Glu Lys Glu Asp Val Arg Ile Leu Lys Val Cys Phe Tyr Ser Asn 
        35                  40                  45              


Ser Phe Asn Pro Gly Lys Asn Phe Lys Leu Val Lys Cys Thr Val Gln 
    50                  55                  60                  


Thr Glu Ile Arg Glu Ile Ile Thr Ser Ile Leu Leu Ser Gly Arg Ile 
65                  70                  75                  80  


Gly Pro Asn Ile Arg Leu Ala Glu Cys Tyr Gly Leu Arg Leu Lys His 
                85                  90                  95      


Met Lys Ser Asp Glu Ile His Trp Leu His Pro Gln Met Thr Val Gly 
            100                 105                 110         


Glu Val Gln Asp Lys Tyr Glu Cys Leu His Val Glu Ala Glu Trp Arg 
        115                 120                 125             


Tyr Asp Leu Gln Ile Arg Tyr Leu Pro Glu Asp Phe Met Glu Ser Leu 
    130                 135                 140                 


Lys Glu Asp Arg Thr Thr Leu Leu Tyr Phe Tyr Gln Gln Leu Arg Asn 
145                 150                 155                 160 


Asp Tyr Met Gln Arg Tyr Ala Ser Lys Val Ser Glu Gly Met Ala Leu 
                165                 170                 175     


Gln Leu Gly Cys Leu Glu Leu Arg Arg Phe Phe Lys Asp Met Pro His 
            180                 185                 190         


Asn Ala Leu Asp Lys Lys Ser Asn Phe Glu Leu Leu Glu Lys Glu Val 
        195                 200                 205             


Gly Leu Asp Leu Phe Phe Pro Lys Gln Met Gln Glu Asn Leu Lys Pro 
    210                 215                 220                 


Lys Gln Phe Arg Lys Met Ile Gln Gln Thr Phe Gln Gln Tyr Ala Ser 
225                 230                 235                 240 


Leu Arg Glu Glu Glu Cys Val Met Lys Phe Phe Asn Thr Leu Ala Gly 
                245                 250                 255     


Phe Ala Asn Ile Asp Gln Glu Thr Tyr Arg Cys Glu Leu Ile Gln Gly 
            260                 265                 270         


Trp Asn Ile Thr Val Asp Leu Val Ile Gly Pro Lys Gly Ile Arg Gln 
        275                 280                 285             


Leu Thr Ser Gln Asp Ala Lys Pro Thr Cys Leu Ala Glu Phe Lys Gln 
    290                 295                 300                 


Ile Arg Ser Ile Arg Cys Leu Pro Leu Glu Glu Gly Gln Ala Val Leu 
305                 310                 315                 320 


Gln Leu Gly Ile Glu Gly Ala Pro Gln Ala Leu Ser Ile Lys Thr Ser 
                325                 330                 335     


Ser Leu Ala Glu Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys 
            340                 345                 350         


Arg Leu Gln Gly Glu His Gln Gly Ser Leu Ile Ile His Pro Arg Lys 
        355                 360                 365             


Asp Gly Glu Lys Arg Asn Ser Leu Pro Gln Ile Pro Met Leu Asn Leu 
    370                 375                 380                 


Glu Ala Arg Arg Ser His Leu Ser Glu Ser Cys Ser Ile Glu Ser Asp 
385                 390                 395                 400 


Ile Tyr Ala Glu Ile Pro Asp Glu Thr Leu Arg Arg Pro Gly Gly Pro 
                405                 410                 415     


Gln Tyr Gly Ile Ala Arg Glu Asp Val Val Leu Asn Arg Ile Leu Gly 
            420                 425                 430         


Glu Gly Phe Phe Gly Glu Val Tyr Glu Gly Val Tyr Thr Asn His Lys 
        435                 440                 445             


Gly Glu Lys Ile Asn Val Ala Val Lys Thr Cys Lys Lys Asp Cys Thr 
    450                 455                 460                 


Leu Asp Asn Lys Glu Lys Phe Met Ser Glu Ala Val Ile Met Lys Asn 
465                 470                 475                 480 


Leu Asp His Pro His Ile Val Lys Leu Ile Gly Ile Ile Glu Glu Glu 
                485                 490                 495     


Pro Thr Trp Ile Ile Met Glu Leu Tyr Pro Tyr Gly Glu Leu Gly His 
            500                 505                 510         


Tyr Leu Glu Arg Asn Lys Asn Ser Leu Lys Val Leu Thr Leu Val Leu 
        515                 520                 525             


Tyr Ser Leu Gln Ile Cys Lys Ala Met Ala Tyr Leu Glu Ser Ile Asn 
    530                 535                 540                 


Cys Val His Arg Asp Ile Ala Val Arg Asn Ile Leu Val Ala Ser Pro 
545                 550                 555                 560 


Glu Cys Val Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Ile Glu Asp 
                565                 570                 575     


Glu Asp Tyr Tyr Lys Ala Ser Val Thr Arg Leu Pro Ile Lys Trp Met 
            580                 585                 590         


Ser Pro Glu Ser Ile Asn Phe Arg Arg Phe Thr Thr Ala Ser Asp Val 
        595                 600                 605             


Trp Met Phe Ala Val Cys Met Trp Glu Ile Leu Ser Phe Gly Lys Gln 
    610                 615                 620                 


Pro Phe Phe Trp Leu Glu Asn Lys Asp Val Ile Gly Val Leu Glu Lys 
625                 630                 635                 640 


Gly Asp Arg Leu Pro Lys Pro Asp Leu Cys Pro Pro Val Leu Tyr Thr 
                645                 650                 655     


Leu Met Thr Arg Cys Trp Asp Tyr Asp Pro Ser Asp Arg Pro Arg Phe 
            660                 665                 670         


Thr Glu Leu Val Cys Ser Leu Ser Asp Val Tyr Gln Met Glu Lys Asp 
        675                 680                 685             


Ile Ala Met Glu Gln Glu Arg Asn Ala Arg Tyr Arg Thr Pro Lys Ile 
    690                 695                 700                 


Leu Glu Pro Thr Ala Phe Gln Glu Pro Pro Pro Lys Pro Ser Arg Pro 
705                 710                 715                 720 


Lys Tyr Arg Pro Pro Pro Gln Thr Asn Leu Leu Ala Pro Lys Leu Gln 
                725                 730                 735     


Phe Gln Val Pro Glu Gly Leu Cys Ala Ser Ser Pro Thr Leu Thr Ser 
            740                 745                 750         


Pro Met Glu Tyr Pro Ser Pro Val Asn Ser Leu His Thr Pro Pro Leu 
        755                 760                 765             


His Arg His Asn Val Phe Lys Arg His Ser Met Arg Glu Glu Asp Phe 
    770                 775                 780                 


Ile Gln Pro Ser Ser Arg Glu Glu Ala Gln Gln Leu Trp Glu Ala Glu 
785                 790                 795                 800 


Lys Val Lys Met Arg Gln Ile Leu Asp Lys Gln Gln Lys Gln Met Val 
                805                 810                 815     


Glu Asp Tyr Gln Trp Leu Arg Gln Glu Glu Lys Ser Leu Asp Pro Met 
            820                 825                 830         


Val Tyr Met Asn Asp Lys Ser Pro Leu Thr Pro Glu Lys Glu Val Gly 
        835                 840                 845             


Tyr Leu Glu Phe Thr Gly Pro Pro Gln Lys Pro Pro Arg Leu Gly Ala 
    850                 855                 860                 


Gln Ser Ile Gln Pro Thr Ala Asn Leu Asp Arg Thr Asp Asp Leu Val 
865                 870                 875                 880 


Tyr Leu Asn Val Met Glu Leu Val Arg Ala Val Leu Glu Leu Lys Asn 
                885                 890                 895     


Glu Leu Cys Gln Leu Pro Pro Glu Gly Tyr Val Val Val Val Lys Asn 
            900                 905                 910         


Val Gly Leu Thr Leu Arg Lys Leu Ile Gly Ser Val Asp Asp Leu Leu 
        915                 920                 925             


Pro Ser Leu Pro Ser Ser Ser Arg Thr Glu Ile Glu Gly Thr Gln Lys 
    930                 935                 940                 


Leu Leu Asn Lys Asp Leu Ala Glu Leu Ile Asn Lys Met Arg Leu Ala 
945                 950                 955                 960 


Gln Gln Asn Ala Val Thr Ser Leu Ser Glu Glu Cys Lys Arg Gln Met 
                965                 970                 975     


Leu Thr Ala Ser His Thr Leu Ala Val Asp Ala Lys Asn Leu Leu Asp 
            980                 985                 990         


Ala Val Asp Gln Ala Lys Val Leu  Ala Asn Leu Ala His  Pro Pro Ala 
        995                 1000                 1005             


Glu 
    


<210>  16
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Asn Gly Thr Leu Asp His Pro Asp Gln Pro Asp Leu Asp Ala Ile 
1               5                   10                  15      


Lys Met Phe Val Gly Gln Val Pro Arg Thr Trp Ser Glu Lys Asp Leu 
            20                  25                  30          


Arg Glu Leu Phe Glu Gln Tyr Gly Ala Val Tyr Glu Ile Asn Val Leu 
        35                  40                  45              


Arg Asp Arg Ser Gln Asn Pro Pro Gln Ser Lys Gly Cys Cys Phe Val 
    50                  55                  60                  


Thr Phe Tyr Thr Arg Lys Ala Ala Leu Glu Ala Gln Asn Ala Leu His 
65                  70                  75                  80  


Asn Met Lys Val Leu Pro Gly Met His His Pro Ile Gln Met Lys Pro 
                85                  90                  95      


Ala Asp Ser Glu Lys Asn Asn Ala Val Glu Asp Arg Lys Leu Phe Ile 
            100                 105                 110         


Gly Met Ile Ser Lys Lys Cys Thr Glu Asn Asp Ile Arg Val Met Phe 
        115                 120                 125             


Ser Ser Phe Gly Gln Ile Glu Glu Cys Arg Ile Leu Arg Gly Pro Asp 
    130                 135                 140                 


Gly Leu Ser Arg Gly Cys Ala Phe Val Thr Phe Thr Thr Arg Ala Met 
145                 150                 155                 160 


Ala Gln Thr Ala Ile Lys Ala Met His Gln Ala Gln Thr Met Glu Gly 
                165                 170                 175     


Cys Ser Ser Pro Met Val Val Lys Phe Ala Asp Thr Gln Lys Asp Lys 
            180                 185                 190         


Glu Gln Lys Arg Met Ala Gln Gln Leu Gln Gln Gln Met Gln Gln Ile 
        195                 200                 205             


Ser Ala Ala Ser Val Trp Gly Asn Leu Ala Gly Leu Asn Thr Leu Gly 
    210                 215                 220                 


Pro Gln Tyr Leu Ala Leu Tyr Leu Gln Leu Leu Gln Gln Thr Ala Ser 
225                 230                 235                 240 


Ser Gly Asn Leu Asn Thr Leu Ser Ser Leu His Pro Met Gly Gly Leu 
                245                 250                 255     


Asn Ala Met Gln Leu Gln Asn Leu Ala Ala Leu Ala Ala Ala Ala Ser 
            260                 265                 270         


Ala Ala Gln Asn Thr Pro Ser Gly Thr Asn Ala Leu Thr Thr Ser Ser 
        275                 280                 285             


Ser Pro Leu Ser Val Leu Thr Ser Ser Gly Ser Ser Pro Ser Ser Ser 
    290                 295                 300                 


Ser Ser Asn Ser Val Asn Pro Ile Ala Ser Leu Gly Ala Leu Gln Thr 
305                 310                 315                 320 


Leu Ala Gly Ala Thr Ala Gly Leu Asn Val Gly Ser Leu Ala Gly Met 
                325                 330                 335     


Ala Ala Leu Asn Gly Gly Leu Gly Ser Ser Gly Leu Ser Asn Gly Thr 
            340                 345                 350         


Gly Ser Thr Met Glu Ala Leu Thr Gln Ala Tyr Ser Gly Ile Gln Gln 
        355                 360                 365             


Tyr Ala Ala Ala Ala Leu Pro Thr Leu Tyr Asn Gln Asn Leu Leu Thr 
    370                 375                 380                 


Gln Gln Ser Ile Gly Ala Ala Gly Ser Gln Lys Glu Gly Pro Glu Gly 
385                 390                 395                 400 


Ala Asn Leu Phe Ile Tyr His Leu Pro Gln Glu Phe Gly Asp Gln Asp 
                405                 410                 415     


Leu Leu Gln Met Phe Met Pro Phe Gly Asn Val Val Ser Ala Lys Val 
            420                 425                 430         


Phe Ile Asp Lys Gln Thr Asn Leu Ser Lys Cys Phe Gly Phe Val Ser 
        435                 440                 445             


Tyr Asp Asn Pro Val Ser Ala Gln Ala Ala Ile Gln Ser Met Asn Gly 
    450                 455                 460                 


Phe Gln Ile Gly Met Lys Arg Leu Lys Val Gln Leu Lys Arg Ser Lys 
465                 470                 475                 480 


Asn Asp Ser Lys Pro Tyr 
                485     


<210>  17
<211>  1189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Met Val Pro Cys Trp Asn His Gly Asn Ile Thr Arg Ser Lys Ala Glu 
1               5                   10                  15      


Glu Leu Leu Ser Arg Thr Gly Lys Asp Gly Ser Phe Leu Val Arg Ala 
            20                  25                  30          


Ser Glu Ser Ile Ser Arg Ala Tyr Ala Leu Cys Val Leu Tyr Arg Asn 
        35                  40                  45              


Cys Val Tyr Thr Tyr Arg Ile Leu Pro Asn Glu Asp Asp Lys Phe Thr 
    50                  55                  60                  


Val Gln Ala Ser Glu Gly Val Ser Met Arg Phe Phe Thr Lys Leu Asp 
65                  70                  75                  80  


Gln Leu Ile Glu Phe Tyr Lys Lys Glu Asn Met Gly Leu Val Thr His 
                85                  90                  95      


Leu Gln Tyr Pro Val Pro Leu Glu Glu Glu Asp Thr Gly Asp Asp Pro 
            100                 105                 110         


Glu Glu Asp Thr Val Glu Ser Val Val Ser Pro Pro Glu Leu Pro Pro 
        115                 120                 125             


Arg Asn Ile Pro Leu Thr Ala Ser Ser Cys Glu Ala Lys Glu Val Pro 
    130                 135                 140                 


Phe Ser Asn Glu Asn Pro Arg Ala Thr Glu Thr Ser Arg Pro Ser Leu 
145                 150                 155                 160 


Ser Glu Thr Leu Phe Gln Arg Leu Gln Ser Met Asp Thr Ser Gly Leu 
                165                 170                 175     


Pro Glu Glu His Leu Lys Ala Ile Gln Asp Tyr Leu Ser Thr Gln Leu 
            180                 185                 190         


Ala Gln Asp Ser Glu Phe Val Lys Thr Gly Ser Ser Ser Leu Pro His 
        195                 200                 205             


Leu Lys Lys Leu Thr Thr Leu Leu Cys Lys Glu Leu Tyr Gly Glu Val 
    210                 215                 220                 


Ile Arg Thr Leu Pro Ser Leu Glu Ser Leu Gln Arg Leu Phe Asp Gln 
225                 230                 235                 240 


Gln Leu Ser Pro Gly Leu Arg Pro Arg Pro Gln Val Pro Gly Glu Ala 
                245                 250                 255     


Asn Pro Ile Asn Met Val Ser Lys Leu Ser Gln Leu Thr Ser Leu Leu 
            260                 265                 270         


Ser Ser Ile Glu Asp Lys Val Lys Ala Leu Leu His Glu Gly Pro Glu 
        275                 280                 285             


Ser Pro His Arg Pro Ser Leu Ile Pro Pro Val Thr Phe Glu Val Lys 
    290                 295                 300                 


Ala Glu Ser Leu Gly Ile Pro Gln Lys Met Gln Leu Lys Val Asp Val 
305                 310                 315                 320 


Glu Ser Gly Lys Leu Ile Ile Lys Lys Ser Lys Asp Gly Ser Glu Asp 
                325                 330                 335     


Lys Phe Tyr Ser His Lys Lys Ile Leu Gln Leu Ile Lys Ser Gln Lys 
            340                 345                 350         


Phe Leu Asn Lys Leu Val Ile Leu Val Glu Thr Glu Lys Glu Lys Ile 
        355                 360                 365             


Leu Arg Lys Glu Tyr Val Phe Ala Asp Ser Lys Lys Arg Glu Gly Phe 
    370                 375                 380                 


Cys Gln Leu Leu Gln Gln Met Lys Asn Lys His Ser Glu Gln Pro Glu 
385                 390                 395                 400 


Pro Asp Met Ile Thr Ile Phe Ile Gly Thr Trp Asn Met Gly Asn Ala 
                405                 410                 415     


Pro Pro Pro Lys Lys Ile Thr Ser Trp Phe Leu Ser Lys Gly Gln Gly 
            420                 425                 430         


Lys Thr Arg Asp Asp Ser Ala Asp Tyr Ile Pro His Asp Ile Tyr Val 
        435                 440                 445             


Ile Gly Thr Gln Glu Asp Pro Leu Ser Glu Lys Glu Trp Leu Glu Ile 
    450                 455                 460                 


Leu Lys His Ser Leu Gln Glu Ile Thr Ser Val Thr Phe Lys Thr Val 
465                 470                 475                 480 


Ala Ile His Thr Leu Trp Asn Ile Arg Ile Val Val Leu Ala Lys Pro 
                485                 490                 495     


Glu His Glu Asn Arg Ile Ser His Ile Cys Thr Asp Asn Val Lys Thr 
            500                 505                 510         


Gly Ile Ala Asn Thr Leu Gly Asn Lys Gly Ala Val Gly Val Ser Phe 
        515                 520                 525             


Met Phe Asn Gly Thr Ser Leu Gly Phe Val Asn Ser His Leu Thr Ser 
    530                 535                 540                 


Gly Ser Glu Lys Lys Leu Arg Arg Asn Gln Asn Tyr Met Asn Ile Leu 
545                 550                 555                 560 


Arg Phe Leu Ala Leu Gly Asp Lys Lys Leu Ser Pro Phe Asn Ile Thr 
                565                 570                 575     


His Arg Phe Thr His Leu Phe Trp Phe Gly Asp Leu Asn Tyr Arg Val 
            580                 585                 590         


Asp Leu Pro Thr Trp Glu Ala Glu Thr Ile Ile Gln Lys Ile Lys Gln 
        595                 600                 605             


Gln Gln Tyr Ala Asp Leu Leu Ser His Asp Gln Leu Leu Thr Glu Arg 
    610                 615                 620                 


Arg Glu Gln Lys Val Phe Leu His Phe Glu Glu Glu Glu Ile Thr Phe 
625                 630                 635                 640 


Ala Pro Thr Tyr Arg Phe Glu Arg Leu Thr Arg Asp Lys Tyr Ala Tyr 
                645                 650                 655     


Thr Lys Gln Lys Ala Thr Gly Met Lys Tyr Asn Leu Pro Ser Trp Cys 
            660                 665                 670         


Asp Arg Val Leu Trp Lys Ser Tyr Pro Leu Val His Val Val Cys Gln 
        675                 680                 685             


Ser Tyr Gly Ser Thr Ser Asp Ile Met Thr Ser Asp His Ser Pro Val 
    690                 695                 700                 


Phe Ala Thr Phe Glu Ala Gly Val Thr Ser Gln Phe Val Ser Lys Asn 
705                 710                 715                 720 


Gly Pro Gly Thr Val Asp Ser Gln Gly Gln Ile Glu Phe Leu Arg Cys 
                725                 730                 735     


Tyr Ala Thr Leu Lys Thr Lys Ser Gln Thr Lys Phe Tyr Leu Glu Phe 
            740                 745                 750         


His Ser Ser Cys Leu Glu Ser Phe Val Lys Ser Gln Glu Gly Glu Asn 
        755                 760                 765             


Glu Glu Gly Ser Glu Gly Glu Leu Val Val Lys Phe Gly Glu Thr Leu 
    770                 775                 780                 


Pro Lys Leu Lys Pro Ile Ile Ser Asp Pro Glu Tyr Leu Leu Asp Gln 
785                 790                 795                 800 


His Ile Leu Ile Ser Ile Lys Ser Ser Asp Ser Asp Glu Ser Tyr Gly 
                805                 810                 815     


Glu Gly Cys Ile Ala Leu Arg Leu Glu Ala Thr Glu Thr Gln Leu Pro 
            820                 825                 830         


Ile Tyr Thr Pro Leu Thr His His Gly Glu Leu Thr Gly His Phe Gln 
        835                 840                 845             


Gly Glu Ile Lys Leu Gln Thr Ser Gln Gly Lys Thr Arg Glu Lys Leu 
    850                 855                 860                 


Tyr Asp Phe Val Lys Thr Glu Arg Asp Glu Ser Ser Gly Pro Lys Thr 
865                 870                 875                 880 


Leu Lys Ser Leu Thr Ser His Asp Pro Met Lys Gln Trp Glu Val Thr 
                885                 890                 895     


Ser Arg Ala Pro Pro Cys Ser Gly Ser Ser Ile Thr Glu Ile Ile Asn 
            900                 905                 910         


Pro Asn Tyr Met Gly Val Gly Pro Phe Gly Pro Pro Met Pro Leu His 
        915                 920                 925             


Val Lys Gln Thr Leu Ser Pro Asp Gln Gln Pro Thr Ala Trp Ser Tyr 
    930                 935                 940                 


Asp Gln Pro Pro Lys Asp Ser Pro Leu Gly Pro Cys Arg Gly Glu Ser 
945                 950                 955                 960 


Pro Pro Thr Pro Pro Gly Gln Pro Pro Ile Ser Pro Lys Lys Phe Leu 
                965                 970                 975     


Pro Ser Thr Ala Asn Arg Gly Leu Pro Pro Arg Thr Gln Glu Ser Arg 
            980                 985                 990         


Pro Ser Asp Leu Gly Lys Asn Ala  Gly Asp Thr Leu Pro  Gln Glu Asp 
        995                 1000                 1005             


Leu Pro  Leu Thr Lys Pro Glu  Met Phe Glu Asn Pro  Leu Tyr Gly 
    1010                 1015                 1020             


Ser Leu  Ser Ser Phe Pro Lys  Pro Ala Pro Arg Lys  Asp Gln Glu 
    1025                 1030                 1035             


Ser Pro  Lys Met Pro Arg Lys  Glu Pro Pro Pro Cys  Pro Glu Pro 
    1040                 1045                 1050             


Gly Ile  Leu Ser Pro Ser Ile  Val Leu Thr Lys Ala  Gln Glu Ala 
    1055                 1060                 1065             


Asp Arg  Gly Glu Gly Pro Gly  Lys Gln Val Pro Ala  Pro Arg Leu 
    1070                 1075                 1080             


Arg Ser  Phe Thr Cys Ser Ser  Ser Ala Glu Gly Arg  Ala Ala Gly 
    1085                 1090                 1095             


Gly Asp  Lys Ser Gln Gly Lys  Pro Lys Thr Pro Val  Ser Ser Gln 
    1100                 1105                 1110             


Ala Pro  Val Pro Ala Lys Arg  Pro Ile Lys Pro Ser  Arg Ser Glu 
    1115                 1120                 1125             


Ile Asn  Gln Gln Thr Pro Pro  Thr Pro Thr Pro Arg  Pro Pro Leu 
    1130                 1135                 1140             


Pro Val  Lys Ser Pro Ala Val  Leu His Leu Gln His  Ser Lys Gly 
    1145                 1150                 1155             


Arg Asp  Tyr Arg Asp Asn Thr  Glu Leu Pro His His  Gly Lys His 
    1160                 1165                 1170             


Arg Pro  Glu Glu Gly Pro Pro  Gly Pro Leu Gly Arg  Thr Ala Met 
    1175                 1180                 1185             


Gln 
    


<210>  18
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
    50                  55                  60                  


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
65                  70                  75                  80  


Asn Ser Asp Ile Val Glu Thr Leu Arg Lys Lys Gly Leu Asn Gly Cys 
                85                  90                  95      


Asp Ser Pro Asp Pro Asp Ala Asp Asp Ser Val Gly His Ser Pro Glu 
            100                 105                 110         


Ser Glu Asp Lys Tyr Arg Lys Ile Asn Glu Asp Ile Asp Leu Met Ile 
        115                 120                 125             


Ser Arg Gln Arg Leu Cys Ala Val Pro Pro Pro Asn Phe Glu Met Pro 
    130                 135                 140                 


Val Ser Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro 
145                 150                 155                 160 


Val Ser Ser Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser 
                165                 170                 175     


Leu Gln Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser 
            180                 185                 190         


Ala Gly Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala 
        195                 200                 205             


Gly Thr Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly 
    210                 215                 220                 


Leu Leu Val Ser Pro Gly Asn Leu Asn Lys Asn Met Gln Ala Lys Ser 
225                 230                 235                 240 


Pro Pro Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg 
                245                 250                 255     


Val Leu Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Ser Glu 
            260                 265                 270         


Asp Val Asp Leu Leu Leu Asn Gln Arg Ile Asn Asn Ser Gln Ser Ala 
        275                 280                 285             


Gln Ser Leu Ala Thr Pro Val Val Ser Val Ala Thr Pro Thr Leu Pro 
    290                 295                 300                 


Gly Gln Gly Met Gly Gly Tyr Pro Ser Ala Ile Ser Thr Thr Tyr Gly 
305                 310                 315                 320 


Thr Glu Tyr Ser Leu Ser Ser Ala Asp Leu Ser Ser Leu Ser Gly Phe 
                325                 330                 335     


Asn Thr Ala Ser Ala Leu His Leu Gly Ser Val Thr Gly Trp Gln Gln 
            340                 345                 350         


Gln His Leu His Asn Met Pro Pro Ser Ala Leu Ser Gln Leu Gly Ala 
        355                 360                 365             


Cys Thr Ser Thr His Leu Ser Gln Ser Ser Asn Leu Ser Leu Pro Ser 
    370                 375                 380                 


Thr Gln Ser Leu Asn Ile Lys Ser Glu Pro Val Ser Pro Pro Arg Asp 
385                 390                 395                 400 


Arg Thr Thr Thr Pro Ser Arg Tyr Pro Gln His Thr Arg His Glu Ala 
                405                 410                 415     


Gly Arg Ser Pro Val Asp Ser Leu Ser Ser Cys Ser Ser Ser Tyr Asp 
            420                 425                 430         


Gly Ser Asp Arg Glu Asp His Arg Asn Glu Phe His Ser Pro Ile Gly 
        435                 440                 445             


Leu Thr Arg Pro Ser Pro Asp Glu Arg Glu Ser Pro Ser Val Lys Arg 
    450                 455                 460                 


Met Arg Leu Ser Glu Gly Trp Ala Thr 
465                 470             


<210>  19
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Met Met Thr Thr Leu Gln Asn Lys Glu Glu Cys Gly Lys Gly Pro Lys 
1               5                   10                  15      


Arg Ile Phe Ala Pro Pro Ala Gln Lys Ser Tyr Ser Leu Leu Pro Cys 
            20                  25                  30          


Ser Pro Asn Ser Pro Lys Glu Glu Thr Pro Gly Ile Ser Ser Pro Glu 
        35                  40                  45              


Thr Glu Ala Arg Ile Ser Leu Pro Lys Ala Ser Leu Lys Lys Lys Glu 
    50                  55                  60                  


Glu Lys Ala Thr Met Lys Asn Val Pro Ser Arg Glu Gln Glu Lys Lys 
65                  70                  75                  80  


Arg Lys Ala Gln Ile Asn Lys Gln Ala Glu Lys Lys Glu Lys Glu Lys 
                85                  90                  95      


Ser Ser Leu Thr Asn Ala Glu Phe Glu Glu Ile Val Gln Ile Val Leu 
            100                 105                 110         


Gln Lys Ser Leu Gln Glu Cys Leu Gly Met Gly Ser Gly Leu Asp Phe 
        115                 120                 125             


Ala Glu Thr Ser Cys Ala Gln Pro Val Val Ser Thr Gln Ser Asp Lys 
    130                 135                 140                 


Glu Pro Gly Ile Thr Ala Ser Ala Thr Asp Thr Asp Asn Ala Asn Gly 
145                 150                 155                 160 


Glu Glu Val Pro His Thr Gln Glu Ile Ser Val Ser Trp Glu Gly Glu 
                165                 170                 175     


Ala Ala Pro Glu Ile Arg Thr Ser Lys Leu Gly Gln Pro Asp Pro Ala 
            180                 185                 190         


Pro Ser Lys Lys Lys Ser Asn Arg Leu Thr Leu Ser Lys Arg Lys Lys 
        195                 200                 205             


Glu Ala His Glu Lys Val Glu Lys Thr Gln Gly Gly His Glu His Arg 
    210                 215                 220                 


Gln Glu Asp Arg Leu Lys Lys Thr Val Gln Asp His Ser Gln Ile Arg 
225                 230                 235                 240 


Asp Gln Gln Lys Gly Glu Ile Ser Gly Phe Gly Gln Cys Leu Val Trp 
                245                 250                 255     


Val Gln Cys Ser Phe Pro Asn Cys Gly Lys Trp Arg Arg Leu Cys Gly 
            260                 265                 270         


Asn Ile Asp Pro Ser Val Leu Pro Asp Asn Trp Ser Cys Asp Gln Asn 
        275                 280                 285             


Thr Asp Val Gln Tyr Asn Arg Cys Asp Ile Pro Glu Glu Thr Trp Thr 
    290                 295                 300                 


Gly Leu Glu Ser Asp Val Ala Tyr Ala Ser Tyr Ile Pro Gly Ser Ile 
305                 310                 315                 320 


Ile Trp Ala Lys Gln Tyr Gly Tyr Pro Trp Trp Pro Gly Met Ile Glu 
                325                 330                 335     


Ser Asp Pro Asp Leu Gly Glu Tyr Phe Leu Phe Thr Ser His Leu Asp 
            340                 345                 350         


Ser Leu Pro Ser Lys Tyr His Val Thr Phe Phe Gly Glu Thr Val Ser 
        355                 360                 365             


Arg Ala Trp Ile Pro Val Asn Met Leu Lys Asn Phe Gln Glu Leu Ser 
    370                 375                 380                 


Leu Glu Leu Ser Val Met Lys Lys Arg Arg Asn Asp Cys Ser Gln Lys 
385                 390                 395                 400 


Leu Gly Val Ala Leu Met Met Ala Gln Glu Ala Glu Gln Ile Ser Ile 
                405                 410                 415     


Gln Glu Arg Val Asn Leu Phe Gly Phe Trp Ser Arg Phe Asn Gly Ser 
            420                 425                 430         


Asn Ser Asn Gly Glu Arg Lys Asp Leu Gln Leu Ser Gly Leu Asn Ser 
        435                 440                 445             


Pro Gly Ser Cys Leu Glu Lys Lys Glu Lys Glu Glu Glu Leu Glu Lys 
    450                 455                 460                 


Glu Glu Gly Glu Lys Thr Asp Pro Ile Leu Pro Ile Arg Lys Arg Val 
465                 470                 475                 480 


Lys Ile Gln Thr Gln Lys Thr Lys Pro Arg Gly Leu Gly Gly Asp Ala 
                485                 490                 495     


Gly Thr Ala Asp Gly Arg Gly Arg Thr Leu Gln Arg Lys Ile Met Lys 
            500                 505                 510         


Arg Ser Leu Gly Arg Lys Ser Thr Ala Pro Pro Ala Pro Arg Met Gly 
        515                 520                 525             


Arg Lys Glu Gly Gln Gly Asn Ser Asp Ser Asp Gln Pro Gly Pro Lys 
    530                 535                 540                 


Lys Lys Phe Lys Ala Pro Gln Ser Lys Ala Leu Ala Ala Ser Phe Ser 
545                 550                 555                 560 


Glu Gly Lys Glu Val Arg Thr Val Pro Lys Asn Leu Gly Leu Ser Ala 
                565                 570                 575     


Cys Lys Gly Ala Cys Pro Ser Ser Ala Lys Glu Glu Pro Arg His Arg 
            580                 585                 590         


Glu Pro Leu Thr Gln Glu Ala Gly Ser Val Pro Leu Glu Asp Glu Ala 
        595                 600                 605             


Ser Ser Asp Leu Asp Leu Glu Gln Leu Met Glu Asp Val Gly Arg Glu 
    610                 615                 620                 


Leu Gly Gln Ser Gly Glu Leu Gln His Ser Asn Ser Asp Gly Glu Asp 
625                 630                 635                 640 


Phe Pro Val Ala Leu Phe Gly Lys 
                645             


<210>  20
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  21
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Met His Gln Thr Tyr Ser Arg His Cys Arg Pro Glu Glu Ser Thr Phe 
1               5                   10                  15      


Ser Ala Ala Met Thr Thr Met Gln Gly Met Glu Gln Ala Met Pro Gly 
            20                  25                  30          


Ala Gly Pro Gly Val Pro Gln Leu Gly Asn Met Ala Val Ile His Ser 
        35                  40                  45              


His Leu Trp Lys Gly Leu Gln Glu Lys Phe Leu Lys Gly Glu Pro Lys 
    50                  55                  60                  


Val Leu Gly Val Val Gln Ile Leu Thr Ala Leu Met Ser Leu Ser Met 
65                  70                  75                  80  


Gly Ile Thr Met Met Cys Met Ala Ser Asn Thr Tyr Gly Ser Asn Pro 
                85                  90                  95      


Ile Ser Val Tyr Ile Gly Tyr Thr Ile Trp Gly Ser Val Met Phe Ile 
            100                 105                 110         


Ile Ser Gly Ser Leu Ser Ile Ala Ala Gly Ile Arg Thr Thr Lys Gly 
        115                 120                 125             


Leu Val Arg Gly Ser Leu Gly Met Asn Ile Thr Ser Ser Val Leu Ala 
    130                 135                 140                 


Ala Ser Gly Ile Leu Ile Asn Thr Phe Ser Leu Ala Phe Tyr Ser Phe 
145                 150                 155                 160 


His His Pro Tyr Cys Asn Tyr Tyr Gly Asn Ser Asn Asn Cys His Gly 
                165                 170                 175     


Thr Met Ser Ile Leu Met Gly Leu Asp Gly Met Val Leu Leu Leu Ser 
            180                 185                 190         


Val Leu Glu Phe Cys Ile Ala Val Ser Leu Ser Ala Phe Gly Cys Lys 
        195                 200                 205             


Val Leu Cys Cys Thr Pro Gly Gly Val Val Leu Ile Leu Pro Ser His 
    210                 215                 220                 


Ser His Met Ala Glu Thr Ala Ser Pro Thr Pro Leu Asn Glu Val 
225                 230                 235                 


<210>  22
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Met Ile Arg His Ala Gly Ala Pro Ala Arg Gly Asp Pro Thr Gly Pro 
1               5                   10                  15      


Val Pro Val Val Gly Lys Gly Glu Glu Glu Glu Glu Glu Asp Gly Met 
            20                  25                  30          


Arg Leu Cys Leu Pro Ala Asn Pro Lys Asn Cys Leu Pro His Arg Arg 
        35                  40                  45              


Gly Ile Ser Ile Leu Glu Lys Leu Ile Lys Thr Cys Pro Val Trp Leu 
    50                  55                  60                  


Gln Leu Ser Leu Gly Gln Ala Glu Val Ala Arg Ile Leu His Arg Val 
65                  70                  75                  80  


Val Ala Gly Met Phe Leu Val Arg Arg Asp Ser Ser Ser Lys Gln Leu 
                85                  90                  95      


Val Leu Cys Val His Phe Pro Ser Leu Asn Glu Ser Ser Ala Glu Val 
            100                 105                 110         


Leu Glu Tyr Thr Ile Lys Glu Glu Lys Ser Ile Leu Tyr Leu Glu Gly 
        115                 120                 125             


Ser Ala Leu Val Phe Glu Asp Ile Phe Arg Leu Ile Ala Phe Tyr Cys 
    130                 135                 140                 


Val Ser Arg Asp Leu Leu Pro Phe Thr Leu Arg Leu Pro Gln Ala Ile 
145                 150                 155                 160 


Leu Glu Ala Ser Ser Phe Thr Asp Leu Glu Thr Ile Ala Asn Leu Gly 
                165                 170                 175     


Leu Gly Phe Trp Asp Ser Ser Leu Asn Pro Pro Gln Glu Arg Gly Lys 
            180                 185                 190         


Pro Ala Glu Pro Pro Arg Asp Arg Ala Pro Gly Phe Pro Leu Val Ser 
        195                 200                 205             


Ser Leu Arg Pro Thr Ala His Asp Ala Asn Cys Ala Cys Glu Ile Glu 
    210                 215                 220                 


Leu Ser Val Gly Asn Asp Arg Leu Trp Phe Val Asn Pro Ile Phe Ile 
225                 230                 235                 240 


Glu Asp Cys Ser Ser Ala Leu Pro Thr Asp Gln Pro Pro Leu Gly Asn 
                245                 250                 255     


Cys Pro Ala Arg Pro Leu Pro Pro Thr Ser Asp Ala Thr Ser Pro Thr 
            260                 265                 270         


Ser Arg Trp Ala Pro Arg Arg Pro Pro Pro Pro Pro Pro Val Leu Pro 
        275                 280                 285             


Leu Gln Pro Cys Ser Pro Ala Gln Pro Pro Val Leu Pro Ala Leu Ala 
    290                 295                 300                 


Pro Ala Pro Ala Cys Pro Leu Pro Thr Ser Pro Pro Val Pro Ala Pro 
305                 310                 315                 320 


His Val Thr Pro His Ala Pro Gly Pro Pro Asp His Pro Asn Gln Pro 
                325                 330                 335     


Pro Met Met Thr Cys Glu Arg Leu Pro Cys Pro Thr Ala Gly Leu Gly 
            340                 345                 350         


Pro Leu Arg Glu Glu Ala Met Lys Pro Gly Ala Ala Ser Ser Pro Leu 
        355                 360                 365             


Gln Gln Val Pro Ala Pro Pro Leu Pro Ala Lys Lys Asn Leu Pro Thr 
    370                 375                 380                 


Ala Pro Pro Arg Arg Arg Val Ser Glu Arg Val Ser Leu Glu Asp Gln 
385                 390                 395                 400 


Ser Pro Gly Met Ala Ala Glu Gly Asp Gln Leu Ser Leu Pro Pro Gln 
                405                 410                 415     


Gly Thr Ser Asp Gly Pro Glu Asp Thr Pro Arg Glu Ser Thr Glu Gln 
            420                 425                 430         


Gly Gln Asp Thr Glu Val Lys Ala Ser Asp Pro His Ser Met Pro Glu 
        435                 440                 445             


Leu Pro Arg Thr Ala Lys Gln Pro Pro Val Pro Pro Pro Arg Lys Lys 
    450                 455                 460                 


Arg Ile Ser Arg Gln Leu Ala Ser Thr Leu Pro Ala Pro Leu Glu Asn 
465                 470                 475                 480 


Ala Glu Leu Cys Thr Gln Ala Met Ala Leu Glu Thr Pro Thr Pro Gly 
                485                 490                 495     


Pro Pro Arg Glu Gly Gln Ser Pro Ala Ser Gln Ala Gly Thr Gln His 
            500                 505                 510         


Pro Pro Ala Gln Ala Thr Ala His Ser Gln Ser Ser Pro Glu Phe Lys 
        515                 520                 525             


Gly Ser Leu Ala Ser Leu Ser Asp Ser Leu Gly Val Ser Val Met Ala 
    530                 535                 540                 


Thr Asp Gln Asp Ser Tyr Ser Thr Ser Ser Thr Glu Glu Glu Leu Glu 
545                 550                 555                 560 


Gln Phe Ser Ser Pro Ser Val Lys Lys Lys Pro Ser Met Ile Leu Gly 
                565                 570                 575     


Lys Ala Arg His Arg Leu Ser Phe Ala Ser Phe Ser Ser Met Phe His 
            580                 585                 590         


Ala Phe Leu Ser Asn Asn Arg Lys Leu Tyr Lys Lys Val Val Glu Leu 
        595                 600                 605             


Ala Gln Asp Lys Gly Ser Tyr Phe Gly Ser Leu Val Gln Asp Tyr Lys 
    610                 615                 620                 


Val Tyr Ser Leu Glu Met Met Ala Arg Gln Thr Ser Ser Thr Glu Met 
625                 630                 635                 640 


Leu Gln Glu Ile Arg Thr Met Met Thr Gln Leu Lys Ser Tyr Leu Leu 
                645                 650                 655     


Gln Ser Thr Glu Leu Lys Ala Leu Val Asp Pro Ala Leu His Ser Glu 
            660                 665                 670         


Glu Glu Leu Glu Ala Ile Val Glu Ser Ala Leu Tyr Lys Cys Val Leu 
        675                 680                 685             


Lys Pro Leu Lys Glu Ala Ile Asn Ser Cys Leu His Gln Ile His Ser 
    690                 695                 700                 


Lys Asp Gly Ser Leu Gln Gln Leu Lys Glu Asn Gln Leu Val Ile Leu 
705                 710                 715                 720 


Ala Thr Thr Thr Thr Asp Leu Gly Val Thr Thr Ser Val Pro Glu Val 
                725                 730                 735     


Pro Met Met Glu Lys Ile Leu Gln Lys Phe Thr Ser Met His Lys Ala 
            740                 745                 750         


Tyr Ser Pro Glu Lys Lys Ile Ser Ile Leu Leu Lys Thr Cys Lys Leu 
        755                 760                 765             


Ile Tyr Asp Ser Met Ala Leu Gly Asn Pro Gly Lys Pro Tyr Gly Ala 
    770                 775                 780                 


Asp Asp Phe Leu Pro Val Leu Met Tyr Val Leu Ala Arg Ser Asn Leu 
785                 790                 795                 800 


Thr Glu Met Leu Leu Asn Val Glu Tyr Met Met Glu Leu Met Asp Pro 
                805                 810                 815     


Ala Leu Gln Leu Gly Glu Gly Ser Tyr Tyr Leu Thr Thr Thr Tyr Gly 
            820                 825                 830         


Ala Leu Glu His Ile Lys Ser Tyr Asp Lys Ile Thr Val Thr Arg Gln 
        835                 840                 845             


Leu Ser Val Glu Val Gln Asp Ser Ile His Arg Trp Glu Arg Arg Arg 
    850                 855                 860                 


Thr Leu Asn Lys Ala Arg Ala Ser Arg Ser Ser Val Gln Asp Phe Ile 
865                 870                 875                 880 


Cys Val Ser Tyr Leu Glu Pro Glu Gln Gln Ala Arg Thr Leu Ala Ser 
                885                 890                 895     


Arg Ala Asp Thr Gln Ala Gln Ala Leu Cys Ala Gln Cys Ala Glu Lys 
            900                 905                 910         


Phe Ala Val Glu Arg Pro Gln Ala His Arg Leu Phe Val Leu Val Asp 
        915                 920                 925             


Gly Arg Cys Phe Gln Leu Ala Asp Asp Ala Leu Pro His Cys Ile Lys 
    930                 935                 940                 


Gly Tyr Leu Leu Arg Ser Glu Pro Lys Arg Asp Phe His Phe Val Tyr 
945                 950                 955                 960 


Arg Pro Leu Asp Gly Gly Gly Gly Gly Gly Gly Gly Ser Pro Pro Cys 
                965                 970                 975     


Leu Val Val Arg Glu Pro Asn Phe Leu 
            980                 985 


<210>  23
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Met Glu Arg Arg Trp Pro Leu Gly Leu Gly Leu Val Leu Leu Leu Cys 
1               5                   10                  15      


Ala Pro Leu Pro Pro Gly Ala Arg Ala Lys Glu Val Thr Leu Met Asp 
            20                  25                  30          


Thr Ser Lys Ala Gln Gly Glu Leu Gly Trp Leu Leu Asp Pro Pro Lys 
        35                  40                  45              


Asp Gly Trp Ser Glu Gln Gln Gln Ile Leu Asn Gly Thr Pro Leu Tyr 
    50                  55                  60                  


Met Tyr Gln Asp Cys Pro Met Gln Gly Arg Arg Asp Thr Asp His Trp 
65                  70                  75                  80  


Leu Arg Ser Asn Trp Ile Tyr Arg Gly Glu Glu Ala Ser Arg Val His 
                85                  90                  95      


Val Glu Leu Gln Phe Thr Val Arg Asp Cys Lys Ser Phe Pro Gly Gly 
            100                 105                 110         


Ala Gly Pro Leu Gly Cys Lys Glu Thr Phe Asn Leu Leu Tyr Met Glu 
        115                 120                 125             


Ser Asp Gln Asp Val Gly Ile Gln Leu Arg Arg Pro Leu Phe Gln Lys 
    130                 135                 140                 


Val Thr Thr Val Ala Ala Asp Gln Ser Phe Thr Ile Arg Asp Leu Val 
145                 150                 155                 160 


Ser Gly Ser Val Lys Leu Asn Val Glu Arg Cys Ser Leu Gly Arg Leu 
                165                 170                 175     


Thr Arg Arg Gly Leu Tyr Leu Ala Phe His Asn Pro Gly Ala Cys Val 
            180                 185                 190         


Ala Leu Val Ser Val Arg Val Phe Tyr Gln Arg Cys Pro Glu Thr Leu 
        195                 200                 205             


Asn Gly Leu Ala Gln Phe Pro Asp Thr Leu Pro Gly Pro Ala Gly Leu 
    210                 215                 220                 


Val Glu Val Ala Gly Thr Cys Leu Pro His Ala Arg Ala Ser Pro Arg 
225                 230                 235                 240 


Pro Ser Gly Ala Pro Arg Met His Cys Ser Pro Asp Gly Glu Trp Leu 
                245                 250                 255     


Val Pro Val Gly Arg Cys His Cys Glu Pro Gly Tyr Glu Glu Gly Gly 
            260                 265                 270         


Ser Gly Glu Ala Cys Val Ala Cys Pro Ser Gly Ser Tyr Arg Met Asp 
        275                 280                 285             


Met Asp Thr Pro His Cys Leu Thr Cys Pro Gln Gln Ser Thr Ala Glu 
    290                 295                 300                 


Ser Glu Gly Ala Thr Ile Cys Thr Cys Glu Ser Gly His Tyr Arg Ala 
305                 310                 315                 320 


Pro Gly Glu Gly Pro Gln Val Ala Cys Thr Gly Pro Pro Ser Ala Pro 
                325                 330                 335     


Arg Asn Leu Ser Phe Ser Ala Ser Gly Thr Gln Leu Ser Leu Arg Trp 
            340                 345                 350         


Glu Pro Pro Ala Asp Thr Gly Gly Arg Gln Asp Val Arg Tyr Ser Val 
        355                 360                 365             


Arg Cys Ser Gln Cys Gln Gly Thr Ala Gln Asp Gly Gly Pro Cys Gln 
    370                 375                 380                 


Pro Cys Gly Val Gly Val His Phe Ser Pro Gly Ala Arg Gly Leu Thr 
385                 390                 395                 400 


Thr Pro Ala Val His Val Asn Gly Leu Glu Pro Tyr Ala Asn Tyr Thr 
                405                 410                 415     


Phe Asn Val Glu Ala Gln Asn Gly Val Ser Gly Leu Gly Ser Ser Gly 
            420                 425                 430         


His Ala Ser Thr Ser Val Ser Ile Ser Met Gly His Ala Glu Ser Leu 
        435                 440                 445             


Ser Gly Leu Ser Leu Arg Leu Val Lys Lys Glu Pro Arg Gln Leu Glu 
    450                 455                 460                 


Leu Thr Trp Ala Gly Ser Arg Pro Arg Ser Pro Gly Ala Asn Leu Thr 
465                 470                 475                 480 


Tyr Glu Leu His Val Leu Asn Gln Asp Glu Glu Arg Tyr Gln Met Val 
                485                 490                 495     


Leu Glu Pro Arg Val Leu Leu Thr Glu Leu Gln Pro Asp Thr Thr Tyr 
            500                 505                 510         


Ile Val Arg Val Arg Met Leu Thr Pro Leu Gly Pro Gly Pro Phe Ser 
        515                 520                 525             


Pro Asp His Glu Phe Arg Thr Ser Pro Pro Val Ser Arg Gly Leu Thr 
    530                 535                 540                 


Gly Gly Glu Ile Val Ala Val Ile Phe Gly Leu Leu Leu Gly Ala Ala 
545                 550                 555                 560 


Leu Leu Leu Gly Ile Leu Val Phe Arg Ser Arg Arg Ala Gln Arg Gln 
                565                 570                 575     


Arg Gln Gln Arg Gln Arg Asp Arg Ala Thr Asp Val Asp Arg Glu Asp 
            580                 585                 590         


Lys Leu Trp Leu Lys Pro Tyr Val Asp Leu Gln Ala Tyr Glu Asp Pro 
        595                 600                 605             


Ala Gln Gly Ala Leu Asp Phe Thr Arg Glu Leu Asp Pro Ala Trp Leu 
    610                 615                 620                 


Met Val Asp Thr Val Ile Gly Glu Gly Glu Phe Gly Glu Val Tyr Arg 
625                 630                 635                 640 


Gly Thr Leu Arg Leu Pro Ser Gln Asp Cys Lys Thr Val Ala Ile Lys 
                645                 650                 655     


Thr Leu Lys Asp Thr Ser Pro Gly Gly Gln Trp Trp Asn Phe Leu Arg 
            660                 665                 670         


Glu Ala Thr Ile Met Gly Gln Phe Ser His Pro His Ile Leu His Leu 
        675                 680                 685             


Glu Gly Val Val Thr Lys Arg Lys Pro Ile Met Ile Ile Thr Glu Phe 
    690                 695                 700                 


Met Glu Asn Gly Ala Leu Asp Ala Phe Leu Arg Glu Arg Glu Asp Gln 
705                 710                 715                 720 


Leu Val Pro Gly Gln Leu Val Ala Met Leu Gln Gly Ile Ala Ser Gly 
                725                 730                 735     


Met Asn Tyr Leu Ser Asn His Asn Tyr Val His Arg Asp Leu Ala Ala 
            740                 745                 750         


Arg Asn Ile Leu Val Asn Gln Asn Leu Cys Cys Lys Val Ser Asp Phe 
        755                 760                 765             


Gly Leu Thr Arg Leu Leu Asp Asp Phe Asp Gly Thr Tyr Glu Thr Gln 
    770                 775                 780                 


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala His 
785                 790                 795                 800 


Arg Ile Phe Thr Thr Ala Ser Asp Val Trp Ser Phe Gly Ile Val Met 
                805                 810                 815     


Trp Glu Val Leu Ser Phe Gly Asp Lys Pro Tyr Gly Glu Met Ser Asn 
            820                 825                 830         


Gln Glu Val Met Lys Ser Ile Glu Asp Gly Tyr Arg Leu Pro Pro Pro 
        835                 840                 845             


Val Asp Cys Pro Ala Pro Leu Tyr Glu Leu Met Lys Asn Cys Trp Ala 
    850                 855                 860                 


Tyr Asp Arg Ala Arg Arg Pro His Phe Gln Lys Leu Gln Ala His Leu 
865                 870                 875                 880 


Glu Gln Leu Leu Ala Asn Pro His Ser Leu Arg Thr Ile Ala Asn Phe 
                885                 890                 895     


Asp Pro Arg Met Thr Leu Arg Leu Pro Ser Leu Ser Gly Ser Asp Gly 
            900                 905                 910         


Ile Pro Tyr Arg Thr Val Ser Glu Trp Leu Glu Ser Ile Arg Met Lys 
        915                 920                 925             


Arg Tyr Ile Leu His Phe His Ser Ala Gly Leu Asp Thr Met Glu Cys 
    930                 935                 940                 


Val Leu Glu Leu Thr Ala Glu Asp Leu Thr Gln Met Gly Ile Thr Leu 
945                 950                 955                 960 


Pro Gly His Gln Lys Arg Ile Leu Cys Ser Ile Gln Gly Phe Lys Asp 
                965                 970                 975     


<210>  24
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Met Ser Gly Gln Ser Leu Thr Asp Arg Ile Thr Ala Ala Gln His Ser 
1               5                   10                  15      


Val Thr Gly Ser Ala Val Ser Lys Thr Val Cys Lys Ala Thr Thr His 
            20                  25                  30          


Glu Ile Met Gly Pro Lys Lys Lys His Leu Asp Tyr Leu Ile Gln Cys 
        35                  40                  45              


Thr Asn Glu Met Asn Val Asn Ile Pro Gln Leu Ala Asp Ser Leu Phe 
    50                  55                  60                  


Glu Arg Thr Thr Asn Ser Ser Trp Val Val Val Phe Lys Ser Leu Ile 
65                  70                  75                  80  


Thr Thr His His Leu Met Val Tyr Gly Asn Glu Arg Phe Ile Gln Tyr 
                85                  90                  95      


Leu Ala Ser Arg Asn Thr Leu Phe Asn Leu Ser Asn Phe Leu Asp Lys 
            100                 105                 110         


Ser Gly Leu Gln Gly Tyr Asp Met Ser Thr Phe Ile Arg Arg Tyr Ser 
        115                 120                 125             


Arg Tyr Leu Asn Glu Lys Ala Val Ser Tyr Arg Gln Val Ala Phe Asp 
    130                 135                 140                 


Phe Thr Lys Val Lys Arg Gly Ala Asp Gly Val Met Arg Thr Met Asn 
145                 150                 155                 160 


Thr Glu Lys Leu Leu Lys Thr Val Pro Ile Ile Gln Asn Gln Met Asp 
                165                 170                 175     


Ala Leu Leu Asp Phe Asn Val Asn Ser Asn Glu Leu Thr Asn Gly Val 
            180                 185                 190         


Ile Asn Ala Ala Phe Met Leu Leu Phe Lys Asp Ala Ile Arg Leu Phe 
        195                 200                 205             


Ala Ala Tyr Asn Glu Gly Ile Ile Asn Leu Leu Glu Lys Tyr Phe Asp 
    210                 215                 220                 


Met Lys Lys Asn Gln Cys Lys Glu Gly Leu Asp Ile Tyr Lys Lys Phe 
225                 230                 235                 240 


Leu Thr Arg Met Thr Arg Ile Ser Glu Phe Leu Lys Val Ala Glu Gln 
                245                 250                 255     


Val Gly Ile Asp Arg Gly Asp Ile Pro Asp Leu Ser Gln Ala Pro Ser 
            260                 265                 270         


Ser Leu Leu Asp Ala Leu Glu Gln His Leu Ala Ser Leu Glu Gly Lys 
        275                 280                 285             


Lys Ile Lys Asp Ser Thr Ala Ala Ser Arg Ala Thr Thr Leu Ser Asn 
    290                 295                 300                 


Ala Val Ser Ser Leu Ala Ser Thr Gly Leu Ser Leu Thr Lys Val Asp 
305                 310                 315                 320 


Glu Arg Glu Lys Gln Ala Ala Leu Glu Glu Glu Gln Ala Arg Leu Lys 
                325                 330                 335     


Ala Leu Lys Glu Gln Arg Leu Lys Glu Leu Ala Lys Lys Pro His Thr 
            340                 345                 350         


Ser Leu Thr Thr Ala Ala Ser Pro Val Ser Thr Ser Ala Gly Gly Ile 
        355                 360                 365             


Met Thr Ala Pro Ala Ile Asp Ile Phe Ser Thr Pro Ser Ser Ser Asn 
    370                 375                 380                 


Ser Thr Ser Lys Leu Pro Asn Asp Leu Leu Asp Leu Gln Gln Pro Thr 
385                 390                 395                 400 


Phe His Pro Ser Val His Pro Met Ser Thr Ala Ser Gln Val Ala Ser 
                405                 410                 415     


Thr Trp Gly Asp Pro Phe Ser Ala Thr Val Asp Ala Val Asp Asp Ala 
            420                 425                 430         


Ile Pro Ser Leu Asn Pro Phe Leu Thr Lys Ser Ser Gly Asp Val His 
        435                 440                 445             


Leu Ser Ile Ser Ser Asp Val Ser Thr Phe Thr Thr Arg Thr Pro Thr 
    450                 455                 460                 


His Glu Met Phe Val Gly Phe Thr Pro Ser Pro Val Ala Gln Pro His 
465                 470                 475                 480 


Pro Ser Ala Gly Leu Asn Val Asp Phe Glu Ser Val Phe Gly Asn Lys 
                485                 490                 495     


Ser Thr Asn Val Ile Val Asp Ser Gly Gly Phe Asp Glu Leu Gly Gly 
            500                 505                 510         


Leu Leu Lys Pro Thr Val Ala Ser Gln Asn Gln Asn Leu Pro Val Ala 
        515                 520                 525             


Lys Leu Pro Pro Ser Lys Leu Val Ser Asp Asp Leu Asp Ser Ser Leu 
    530                 535                 540                 


Ala Asn Leu Val Gly Asn Leu Gly Ile Gly Asn Gly Thr Thr Lys Asn 
545                 550                 555                 560 


Asp Val Asn Trp Ser Gln Pro Gly Glu Lys Lys Leu Thr Gly Gly Ser 
                565                 570                 575     


Asn Trp Gln Pro Lys Val Ala Pro Thr Thr Ala Trp Asn Ala Ala Thr 
            580                 585                 590         


Met Ala Pro Pro Val Met Ala Tyr Pro Ala Thr Thr Pro Thr Gly Met 
        595                 600                 605             


Ile Gly Tyr Gly Ile Pro Pro Gln Met Gly Ser Val Pro Val Met Thr 
    610                 615                 620                 


Gln Pro Thr Leu Ile Tyr Ser Gln Pro Val Met Arg Pro Pro Asn Pro 
625                 630                 635                 640 


Phe Gly Pro Val Ser Gly Ala Gln Ile Gln Phe Met 
                645                 650         


<210>  25
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Met Lys Gly Thr Gly Ile Met Asp Cys Ala Pro Lys Ala Leu Leu Ala 
1               5                   10                  15      


Arg Ala Leu Tyr Asp Asn Cys Pro Asp Cys Ser Asp Glu Leu Ala Phe 
            20                  25                  30          


Ser Arg Gly Asp Ile Leu Thr Ile Leu Glu Gln His Val Pro Glu Ser 
        35                  40                  45              


Glu Gly Trp Trp Lys Cys Leu Leu His Gly Arg Gln Gly Leu Ala Pro 
    50                  55                  60                  


Ala Asn Arg Leu Gln Ile Leu Thr Glu Val Ala Ala Asp Arg Pro Cys 
65                  70                  75                  80  


Pro Pro Phe Leu Arg Gly Leu Glu Glu Ala Pro Ala Ser Ser Glu Glu 
                85                  90                  95      


Thr Tyr Gln Val Pro Thr Leu Pro Arg Pro Pro Thr Pro Gly Pro Val 
            100                 105                 110         


Tyr Glu Gln Met Arg Ser Trp Ala Glu Gly Pro Gln Pro Pro Thr Ala 
        115                 120                 125             


Gln Val Tyr Glu Phe Pro Asp Pro Pro Thr Ser Ala Arg Ile Ile Cys 
    130                 135                 140                 


Glu Lys Thr Leu Ser Phe Pro Lys Gln Ala Ile Leu Thr Leu Pro Arg 
145                 150                 155                 160 


Pro Val Arg Ala Ser Leu Pro Thr Leu Pro Ser Gln Val Tyr Asp Val 
                165                 170                 175     


Pro Thr Gln His Arg Gly Pro Val Val Leu Lys Glu Pro Glu Lys Gln 
            180                 185                 190         


Gln Leu Tyr Asp Ile Pro Ala Ser Pro Lys Lys Ala Gly Leu His Pro 
        195                 200                 205             


Pro Asp Ser Gln Ala Ser Gly Gln Gly Val Pro Leu Ile Ser Val Thr 
    210                 215                 220                 


Thr Leu Arg Arg Gly Gly Tyr Ser Thr Leu Pro Asn Pro Gln Lys Ser 
225                 230                 235                 240 


Glu Trp Ile Tyr Asp Thr Pro Val Ser Pro Gly Lys Ala Ser Val Arg 
                245                 250                 255     


Asn Thr Pro Leu Thr Ser Phe Ala Glu Glu Ser Arg Pro His Ala Leu 
            260                 265                 270         


Pro Ser Ser Ser Ser Thr Phe Tyr Asn Pro Pro Ser Gly Arg Ser Arg 
        275                 280                 285             


Ser Leu Thr Pro Gln Leu Asn Asn Asn Val Pro Met Gln Lys Lys Leu 
    290                 295                 300                 


Ser Leu Pro Glu Ile Pro Ser Tyr Gly Phe Leu Val Pro Arg Gly Thr 
305                 310                 315                 320 


Phe Pro Leu Asp Glu Asp Val Ser Tyr Lys Val Pro Ser Ser Phe Leu 
                325                 330                 335     


Ile Pro Arg Val Glu Gln Gln Asn Thr Lys Pro Asn Ile Tyr Asp Ile 
            340                 345                 350         


Pro Lys Ala Thr Ser Ser Val Ser Gln Ala Gly Lys Glu Leu Glu Lys 
        355                 360                 365             


Ala Lys Glu Val Ser Glu Asn Ser Ala Gly His Asn Ser Ser Trp Phe 
    370                 375                 380                 


Ser Arg Arg Thr Thr Ser Pro Ser Pro Glu Pro Asp Arg Leu Ser Gly 
385                 390                 395                 400 


Ser Ser Ser Asp Ser Arg Ala Ser Ile Val Ser Ser Cys Ser Thr Thr 
                405                 410                 415     


Ser Thr Asp Asp Ser Ser Ser Ser Ser Ser Glu Glu Ser Ala Lys Glu 
            420                 425                 430         


Leu Ser Leu Asp Leu Asp Val Ala Lys Glu Thr Val Met Ala Leu Gln 
        435                 440                 445             


His Lys Val Val Ser Ser Val Ala Gly Leu Met Leu Phe Val Ser Arg 
    450                 455                 460                 


Lys Trp Arg Phe Arg Asp Tyr Leu Glu Ala Asn Ile Asp Ala Ile His 
465                 470                 475                 480 


Arg Ser Thr Asp His Ile Glu Glu Ser Val Arg Glu Phe Leu Asp Phe 
                485                 490                 495     


Ala Arg Gly Val His Gly Thr Ala Cys Asn Leu Thr Asp Ser Asn Leu 
            500                 505                 510         


Gln Asn Arg Ile Arg Asp Gln Met Gln Thr Ile Ser Asn Ser Tyr Arg 
        515                 520                 525             


Ile Leu Leu Glu Thr Lys Glu Ser Leu Asp Asn Arg Asn Trp Pro Leu 
    530                 535                 540                 


Glu Val Leu Val Thr Asp Ser Val Gln Asn Ser Pro Asp Asp Leu Glu 
545                 550                 555                 560 


Arg Phe Val Met Val Ala Arg Met Leu Pro Glu Asp Ile Lys Arg Phe 
                565                 570                 575     


Ala Ser Ile Val Ile Ala Asn Gly Arg Leu Leu Phe Lys Arg Asn Cys 
            580                 585                 590         


Glu Lys Glu Glu Thr Val Gln Leu Thr Pro Asn Ala Glu Phe Lys Cys 
        595                 600                 605             


Glu Lys Tyr Ile Gln Pro Pro Gln Arg Glu Thr Glu Ser His Gln Lys 
    610                 615                 620                 


Ser Thr Pro Ser Thr Lys Gln Arg Glu Asp Glu His Ser Ser Glu Leu 
625                 630                 635                 640 


Leu Lys Lys Asn Arg Ala Asn Ile Cys Gly Gln Asn Pro Gly Pro Leu 
                645                 650                 655     


Ile Pro Gln Pro Ser Ser Gln Gln Thr Pro Glu Arg Lys Pro Arg Leu 
            660                 665                 670         


Ser Glu His Cys Arg Leu Tyr Phe Gly Ala Leu Phe Lys Ala Ile Ser 
        675                 680                 685             


Ala Phe His Gly Ser Leu Ser Ser Ser Gln Pro Ala Glu Ile Ile Thr 
    690                 695                 700                 


Gln Ser Lys Leu Val Ile Met Val Gly Gln Lys Leu Val Asp Thr Leu 
705                 710                 715                 720 


Cys Met Glu Thr Gln Glu Arg Asp Val Arg Asn Glu Ile Leu Arg Gly 
                725                 730                 735     


Ser Ser His Leu Cys Ser Leu Leu Lys Asp Val Ala Leu Ala Thr Lys 
            740                 745                 750         


Asn Ala Val Leu Thr Tyr Pro Ser Pro Ala Ala Leu Gly His Leu Gln 
        755                 760                 765             


Ala Glu Ala Glu Lys Leu Glu Gln His Thr Arg Gln Phe Arg Gly Thr 
    770                 775                 780                 


Leu Gly 
785     


<210>  26
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu 
    


<210>  27
<211>  2214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Met Ala Thr Arg Ser Ser Arg Arg Glu Ser Arg Leu Pro Phe Leu Phe 
1               5                   10                  15      


Thr Leu Val Ala Leu Leu Pro Pro Gly Ala Leu Cys Glu Val Trp Thr 
            20                  25                  30          


Gln Arg Leu His Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe 
        35                  40                  45              


Leu Val Val Gln Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly 
    50                  55                  60                  


Asp Ala Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro Leu Arg Arg Lys 
65                  70                  75                  80  


Arg Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val 
                85                  90                  95      


Ser Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu 
            100                 105                 110         


Lys Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala 
        115                 120                 125             


Arg Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser 
    130                 135                 140                 


Phe Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser 
145                 150                 155                 160 


Glu Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg 
                165                 170                 175     


Tyr Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp 
            180                 185                 190         


Phe Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp 
        195                 200                 205             


Leu Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg 
    210                 215                 220                 


Ser His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr 
225                 230                 235                 240 


Trp Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp 
                245                 250                 255     


Pro Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser 
            260                 265                 270         


Gly Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu 
        275                 280                 285             


Asn Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp 
    290                 295                 300                 


Lys Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln 
305                 310                 315                 320 


Gln Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg 
                325                 330                 335     


Ala Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala 
            340                 345                 350         


Asp Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn 
        355                 360                 365             


Arg Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu 
    370                 375                 380                 


Ser Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp 
385                 390                 395                 400 


Thr Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg 
                405                 410                 415     


Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser 
            420                 425                 430         


Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly 
        435                 440                 445             


Thr Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys 
    450                 455                 460                 


Ile Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg 
465                 470                 475                 480 


Leu Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser 
                485                 490                 495     


Lys Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys 
            500                 505                 510         


Asn Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala 
        515                 520                 525             


Arg Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp 
    530                 535                 540                 


His Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu 
545                 550                 555                 560 


Leu Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe 
                565                 570                 575     


Ser Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu 
            580                 585                 590         


Lys Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His 
        595                 600                 605             


Ser Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro 
    610                 615                 620                 


Cys Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly 
625                 630                 635                 640 


Asn Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro 
                645                 650                 655     


His Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val 
            660                 665                 670         


Ser Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe 
        675                 680                 685             


Lys Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu 
    690                 695                 700                 


Phe Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser 
705                 710                 715                 720 


Thr Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys 
                725                 730                 735     


Ser Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys 
            740                 745                 750         


Pro Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser 
        755                 760                 765             


Ile Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu 
    770                 775                 780                 


Thr Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn 
785                 790                 795                 800 


Cys Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys 
                805                 810                 815     


Leu Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu 
            820                 825                 830         


Thr Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp 
        835                 840                 845             


Val Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp 
    850                 855                 860                 


Phe Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala 
865                 870                 875                 880 


Leu Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly 
                885                 890                 895     


Asp Leu Lys Pro Gly Ile Tyr Arg Ser Asn Met Asp Gly Ser Ala Ala 
            900                 905                 910         


Tyr His Leu Val Ser Glu Asp Val Lys Trp Pro Asn Gly Ile Ser Val 
        915                 920                 925             


Asp Asp Gln Trp Ile Tyr Trp Thr Asp Ala Tyr Leu Glu Cys Ile Glu 
    930                 935                 940                 


Arg Ile Thr Phe Ser Gly Gln Gln Arg Ser Val Ile Leu Asp Asn Leu 
945                 950                 955                 960 


Pro His Pro Tyr Ala Ile Ala Val Phe Lys Asn Glu Ile Tyr Trp Asp 
                965                 970                 975     


Asp Trp Ser Gln Leu Ser Ile Phe Arg Ala Ser Lys Tyr Ser Gly Ser 
            980                 985                 990         


Gln Met Glu Ile Leu Ala Asn Gln  Leu Thr Gly Leu Met  Asp Met Lys 
        995                 1000                 1005             


Ile Phe  Tyr Lys Gly Lys Asn  Thr Gly Ser Asn Ala  Cys Val Pro 
    1010                 1015                 1020             


Arg Pro  Cys Ser Leu Leu Cys  Leu Pro Lys Ala Asn  Asn Ser Arg 
    1025                 1030                 1035             


Ser Cys  Arg Cys Pro Glu Asp  Val Ser Ser Ser Val  Leu Pro Ser 
    1040                 1045                 1050             


Gly Asp  Leu Met Cys Asp Cys  Pro Gln Gly Tyr Gln  Leu Lys Asn 
    1055                 1060                 1065             


Asn Thr  Cys Val Lys Gln Glu  Asn Thr Cys Leu Arg  Asn Gln Tyr 
    1070                 1075                 1080             


Arg Cys  Ser Asn Gly Asn Cys  Ile Asn Ser Ile Trp  Trp Cys Asp 
    1085                 1090                 1095             


Phe Asp  Asn Asp Cys Gly Asp  Met Ser Asp Glu Arg  Asn Cys Pro 
    1100                 1105                 1110             


Thr Thr  Ile Cys Asp Leu Asp  Thr Gln Phe Arg Cys  Gln Glu Ser 
    1115                 1120                 1125             


Gly Thr  Cys Ile Pro Leu Ser  Tyr Lys Cys Asp Leu  Glu Asp Asp 
    1130                 1135                 1140             


Cys Gly  Asp Asn Ser Asp Glu  Ser His Cys Glu Met  His Gln Cys 
    1145                 1150                 1155             


Arg Ser  Asp Glu Tyr Asn Cys  Ser Ser Gly Met Cys  Ile Arg Ser 
    1160                 1165                 1170             


Ser Trp  Val Cys Asp Gly Asp  Asn Asp Cys Arg Asp  Trp Ser Asp 
    1175                 1180                 1185             


Glu Ala  Asn Cys Thr Ala Ile  Tyr His Thr Cys Glu  Ala Ser Asn 
    1190                 1195                 1200             


Phe Gln  Cys Arg Asn Gly His  Cys Ile Pro Gln Arg  Trp Ala Cys 
    1205                 1210                 1215             


Asp Gly  Asp Thr Asp Cys Gln  Asp Gly Ser Asp Glu  Asp Pro Val 
    1220                 1225                 1230             


Asn Cys  Glu Lys Lys Cys Asn  Gly Phe Arg Cys Pro  Asn Gly Thr 
    1235                 1240                 1245             


Cys Ile  Pro Ser Ser Lys His  Cys Asp Gly Leu Arg  Asp Cys Ser 
    1250                 1255                 1260             


Asp Gly  Ser Asp Glu Gln His  Cys Glu Pro Leu Cys  Thr His Phe 
    1265                 1270                 1275             


Met Asp  Phe Val Cys Lys Asn  Arg Gln Gln Cys Leu  Phe His Ser 
    1280                 1285                 1290             


Met Val  Cys Asp Gly Ile Ile  Gln Cys Arg Asp Gly  Ser Asp Glu 
    1295                 1300                 1305             


Asp Ala  Ala Phe Ala Gly Cys  Ser Gln Asp Pro Glu  Phe His Lys 
    1310                 1315                 1320             


Val Cys  Asp Glu Phe Gly Phe  Gln Cys Gln Asn Gly  Val Cys Ile 
    1325                 1330                 1335             


Ser Leu  Ile Trp Lys Cys Asp  Gly Met Asp Asp Cys  Gly Asp Tyr 
    1340                 1345                 1350             


Ser Asp  Glu Ala Asn Cys Glu  Asn Pro Thr Glu Ala  Pro Asn Cys 
    1355                 1360                 1365             


Ser Arg  Tyr Phe Gln Phe Arg  Cys Glu Asn Gly His  Cys Ile Pro 
    1370                 1375                 1380             


Asn Arg  Trp Lys Cys Asp Arg  Glu Asn Asp Cys Gly  Asp Trp Ser 
    1385                 1390                 1395             


Asp Glu  Lys Asp Cys Gly Asp  Ser His Ile Leu Pro  Phe Ser Thr 
    1400                 1405                 1410             


Pro Gly  Pro Ser Thr Cys Leu  Pro Asn Tyr Tyr Arg  Cys Ser Ser 
    1415                 1420                 1425             


Gly Thr  Cys Val Met Asp Thr  Trp Val Cys Asp Gly  Tyr Arg Asp 
    1430                 1435                 1440             


Cys Ala  Asp Gly Ser Asp Glu  Glu Ala Cys Pro Leu  Leu Ala Asn 
    1445                 1450                 1455             


Val Thr  Ala Ala Ser Thr Pro  Thr Gln Leu Gly Arg  Cys Asp Arg 
    1460                 1465                 1470             


Phe Glu  Phe Glu Cys His Gln  Pro Lys Thr Cys Ile  Pro Asn Trp 
    1475                 1480                 1485             


Lys Arg  Cys Asp Gly His Gln  Asp Cys Gln Asp Gly  Arg Asp Glu 
    1490                 1495                 1500             


Ala Asn  Cys Pro Thr His Ser  Thr Leu Thr Cys Met  Ser Arg Glu 
    1505                 1510                 1515             


Phe Gln  Cys Glu Asp Gly Glu  Ala Cys Ile Val Leu  Ser Glu Arg 
    1520                 1525                 1530             


Cys Asp  Gly Phe Leu Asp Cys  Ser Asp Glu Ser Asp  Glu Lys Ala 
    1535                 1540                 1545             


Cys Ser  Asp Glu Leu Thr Val  Tyr Lys Val Gln Asn  Leu Gln Trp 
    1550                 1555                 1560             


Thr Ala  Asp Phe Ser Gly Asp  Val Thr Leu Thr Trp  Met Arg Pro 
    1565                 1570                 1575             


Lys Lys  Met Pro Ser Ala Ser  Cys Val Tyr Asn Val  Tyr Tyr Arg 
    1580                 1585                 1590             


Val Val  Gly Glu Ser Ile Trp  Lys Thr Leu Glu Thr  His Ser Asn 
    1595                 1600                 1605             


Lys Thr  Asn Thr Val Leu Lys  Val Leu Lys Pro Asp  Thr Thr Tyr 
    1610                 1615                 1620             


Gln Val  Lys Val Gln Val Gln  Cys Leu Ser Lys Ala  His Asn Thr 
    1625                 1630                 1635             


Asn Asp  Phe Val Thr Leu Arg  Thr Pro Glu Gly Leu  Pro Asp Ala 
    1640                 1645                 1650             


Pro Arg  Asn Leu Gln Leu Ser  Leu Pro Arg Glu Ala  Glu Gly Val 
    1655                 1660                 1665             


Ile Val  Gly His Trp Ala Pro  Pro Ile His Thr His  Gly Leu Ile 
    1670                 1675                 1680             


Arg Glu  Tyr Ile Val Glu Tyr  Ser Arg Ser Gly Ser  Lys Met Trp 
    1685                 1690                 1695             


Ala Ser  Gln Arg Ala Ala Ser  Asn Phe Thr Glu Ile  Lys Asn Leu 
    1700                 1705                 1710             


Leu Val  Asn Thr Leu Tyr Thr  Val Arg Val Ala Ala  Val Thr Ser 
    1715                 1720                 1725             


Arg Gly  Ile Gly Asn Trp Ser  Asp Ser Lys Ser Ile  Thr Thr Ile 
    1730                 1735                 1740             


Lys Gly  Lys Val Ile Pro Pro  Pro Asp Ile His Ile  Asp Ser Tyr 
    1745                 1750                 1755             


Gly Glu  Asn Tyr Leu Ser Phe  Thr Leu Thr Met Glu  Ser Asp Ile 
    1760                 1765                 1770             


Lys Val  Asn Gly Tyr Val Val  Asn Leu Phe Trp Ala  Phe Asp Thr 
    1775                 1780                 1785             


His Lys  Gln Glu Arg Arg Thr  Leu Asn Phe Arg Gly  Ser Ile Leu 
    1790                 1795                 1800             


Ser His  Lys Val Gly Asn Leu  Thr Ala His Thr Ser  Tyr Glu Ile 
    1805                 1810                 1815             


Ser Ala  Trp Ala Lys Thr Asp  Leu Gly Asp Ser Pro  Leu Ala Phe 
    1820                 1825                 1830             


Glu His  Val Met Thr Arg Gly  Val Arg Pro Pro Ala  Pro Ser Leu 
    1835                 1840                 1845             


Lys Ala  Lys Ala Ile Asn Gln  Thr Ala Val Glu Cys  Thr Trp Thr 
    1850                 1855                 1860             


Gly Pro  Arg Asn Val Val Tyr  Gly Ile Phe Tyr Ala  Thr Ser Phe 
    1865                 1870                 1875             


Leu Asp  Leu Tyr Arg Asn Pro  Lys Ser Leu Thr Thr  Ser Leu His 
    1880                 1885                 1890             


Asn Lys  Thr Val Ile Val Ser  Lys Asp Glu Gln Tyr  Leu Phe Leu 
    1895                 1900                 1905             


Val Arg  Val Val Val Pro Tyr  Gln Gly Pro Ser Ser  Asp Tyr Val 
    1910                 1915                 1920             


Val Val  Lys Met Ile Pro Asp  Ser Arg Leu Pro Pro  Arg His Leu 
    1925                 1930                 1935             


His Val  Val His Thr Gly Lys  Thr Ser Val Val Ile  Lys Trp Glu 
    1940                 1945                 1950             


Ser Pro  Tyr Asp Ser Pro Asp  Gln Asp Leu Leu Tyr  Ala Val Ala 
    1955                 1960                 1965             


Val Lys  Asp Leu Ile Arg Lys  Thr Asp Arg Ser Tyr  Lys Val Lys 
    1970                 1975                 1980             


Ser Arg  Asn Ser Thr Val Glu  Tyr Thr Leu Asn Lys  Leu Glu Pro 
    1985                 1990                 1995             


Gly Gly  Lys Tyr His Ile Ile  Val Gln Leu Gly Asn  Met Ser Lys 
    2000                 2005                 2010             


Asp Ser  Ser Ile Lys Ile Thr  Thr Val Ser Leu Ser  Ala Pro Asp 
    2015                 2020                 2025             


Ala Leu  Lys Ile Ile Thr Glu  Asn Asp His Val Leu  Leu Phe Trp 
    2030                 2035                 2040             


Lys Ser  Leu Ala Leu Lys Glu  Lys His Phe Asn Glu  Ser Arg Gly 
    2045                 2050                 2055             


Tyr Glu  Ile His Met Phe Asp  Ser Ala Met Asn Ile  Thr Ala Tyr 
    2060                 2065                 2070             


Leu Gly  Asn Thr Thr Asp Asn  Phe Phe Lys Ile Ser  Asn Leu Lys 
    2075                 2080                 2085             


Met Gly  His Asn Tyr Thr Phe  Thr Val Gln Ala Arg  Cys Leu Phe 
    2090                 2095                 2100             


Gly Asn  Gln Ile Cys Gly Glu  Pro Ala Ile Leu Leu  Tyr Asp Glu 
    2105                 2110                 2115             


Leu Gly  Ser Gly Ala Asp Ala  Ser Ala Thr Gln Ala  Ala Arg Ser 
    2120                 2125                 2130             


Thr Asp  Val Ala Ala Val Val  Val Pro Ile Leu Phe  Leu Ile Leu 
    2135                 2140                 2145             


Leu Ser  Leu Gly Val Gly Phe  Ala Ile Leu Tyr Thr  Lys His Arg 
    2150                 2155                 2160             


Arg Leu  Gln Ser Ser Phe Thr  Ala Phe Ala Asn Ser  His Tyr Ser 
    2165                 2170                 2175             


Ser Arg  Leu Gly Ser Ala Ile  Phe Ser Ser Gly Asp  Asp Leu Gly 
    2180                 2185                 2190             


Glu Asp  Asp Glu Asp Ala Pro  Met Ile Thr Gly Phe  Ser Asp Asp 
    2195                 2200                 2205             


Val Pro  Met Val Ile Ala 
    2210                 


<210>  28
<211>  1265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Ser Thr Thr Val Asn Val Asp Ser Leu Ala Glu Tyr Glu Lys Ser 
1               5                   10                  15      


Gln Ile Lys Arg Ala Leu Glu Leu Gly Thr Val Met Thr Val Phe Ser 
            20                  25                  30          


Phe Arg Lys Ser Thr Pro Glu Arg Arg Thr Val Gln Val Ile Met Glu 
        35                  40                  45              


Thr Arg Gln Val Ala Trp Ser Lys Thr Ala Asp Lys Ile Glu Gly Phe 
    50                  55                  60                  


Leu Asp Ile Met Glu Ile Lys Glu Ile Arg Pro Gly Lys Asn Ser Lys 
65                  70                  75                  80  


Asp Phe Glu Arg Ala Lys Ala Val Arg Gln Lys Glu Asp Cys Cys Phe 
                85                  90                  95      


Thr Ile Leu Tyr Gly Thr Gln Phe Val Leu Ser Thr Leu Ser Leu Ala 
            100                 105                 110         


Ala Asp Ser Lys Glu Asp Ala Val Asn Trp Leu Ser Gly Leu Lys Ile 
        115                 120                 125             


Leu His Gln Glu Ala Met Asn Ala Ser Thr Pro Thr Ile Ile Glu Ser 
    130                 135                 140                 


Trp Leu Arg Lys Gln Ile Tyr Ser Val Asp Gln Thr Arg Arg Asn Ser 
145                 150                 155                 160 


Ile Ser Leu Arg Glu Leu Lys Thr Ile Leu Pro Leu Ile Asn Phe Lys 
                165                 170                 175     


Val Ser Ser Ala Lys Phe Leu Lys Asp Lys Phe Val Glu Ile Gly Ala 
            180                 185                 190         


His Lys Asp Glu Leu Ser Phe Glu Gln Phe His Leu Phe Tyr Lys Lys 
        195                 200                 205             


Leu Met Phe Glu Gln Gln Lys Ser Ile Leu Asp Glu Phe Lys Lys Asp 
    210                 215                 220                 


Ser Ser Val Phe Ile Leu Gly Asn Thr Asp Arg Pro Asp Ala Ser Ala 
225                 230                 235                 240 


Val Tyr Leu His Asp Phe Gln Arg Phe Leu Ile His Glu Gln Gln Glu 
                245                 250                 255     


His Trp Ala Gln Asp Leu Asn Lys Val Arg Glu Arg Met Thr Lys Phe 
            260                 265                 270         


Ile Asp Asp Thr Met Arg Glu Thr Ala Glu Pro Phe Leu Phe Val Asp 
        275                 280                 285             


Glu Phe Leu Thr Tyr Leu Phe Ser Arg Glu Asn Ser Ile Trp Asp Glu 
    290                 295                 300                 


Lys Tyr Asp Ala Val Asp Met Gln Asp Met Asn Asn Pro Leu Ser His 
305                 310                 315                 320 


Tyr Trp Ile Ser Ser Ser His Asn Thr Tyr Leu Thr Gly Asp Gln Leu 
                325                 330                 335     


Arg Ser Glu Ser Ser Pro Glu Ala Tyr Ile Arg Cys Leu Arg Met Gly 
            340                 345                 350         


Cys Arg Cys Ile Glu Leu Asp Cys Trp Asp Gly Pro Asp Gly Lys Pro 
        355                 360                 365             


Val Ile Tyr His Gly Trp Thr Arg Thr Thr Lys Ile Lys Phe Asp Asp 
    370                 375                 380                 


Val Val Gln Ala Ile Lys Asp His Ala Phe Val Thr Ser Ser Phe Pro 
385                 390                 395                 400 


Val Ile Leu Ser Ile Glu Glu His Cys Ser Val Glu Gln Gln Arg His 
                405                 410                 415     


Met Ala Lys Ala Phe Lys Glu Val Phe Gly Asp Leu Leu Leu Thr Lys 
            420                 425                 430         


Pro Thr Glu Ala Ser Ala Asp Gln Leu Pro Ser Pro Ser Gln Leu Arg 
        435                 440                 445             


Glu Lys Ile Ile Ile Lys His Lys Lys Leu Gly Pro Arg Gly Asp Val 
    450                 455                 460                 


Asp Val Asn Met Glu Asp Lys Lys Asp Glu His Lys Gln Gln Gly Glu 
465                 470                 475                 480 


Leu Tyr Met Trp Asp Ser Ile Asp Gln Lys Trp Thr Arg His Tyr Cys 
                485                 490                 495     


Ala Ile Ala Asp Ala Lys Leu Ser Phe Ser Asp Asp Ile Glu Gln Thr 
            500                 505                 510         


Met Glu Glu Glu Val Pro Gln Asp Ile Pro Pro Thr Glu Leu His Phe 
        515                 520                 525             


Gly Glu Lys Trp Phe His Lys Lys Val Glu Lys Arg Thr Ser Ala Glu 
    530                 535                 540                 


Lys Leu Leu Gln Glu Tyr Cys Met Glu Thr Gly Gly Lys Asp Gly Thr 
545                 550                 555                 560 


Phe Leu Val Arg Glu Ser Glu Thr Phe Pro Asn Asp Tyr Thr Leu Ser 
                565                 570                 575     


Phe Trp Arg Ser Gly Arg Val Gln His Cys Arg Ile Arg Ser Thr Met 
            580                 585                 590         


Glu Gly Gly Thr Leu Lys Tyr Tyr Leu Thr Asp Asn Leu Thr Phe Ser 
        595                 600                 605             


Ser Ile Tyr Ala Leu Ile Gln His Tyr Arg Glu Thr His Leu Arg Cys 
    610                 615                 620                 


Ala Glu Phe Glu Leu Arg Leu Thr Asp Pro Val Pro Asn Pro Asn Pro 
625                 630                 635                 640 


His Glu Ser Lys Pro Trp Tyr Tyr Asp Ser Leu Ser Arg Gly Glu Ala 
                645                 650                 655     


Glu Asp Met Leu Met Arg Ile Pro Arg Asp Gly Ala Phe Leu Ile Arg 
            660                 665                 670         


Lys Arg Glu Gly Ser Asp Ser Tyr Ala Ile Thr Phe Arg Ala Arg Gly 
        675                 680                 685             


Lys Val Lys His Cys Arg Ile Asn Arg Asp Gly Arg His Phe Val Leu 
    690                 695                 700                 


Gly Thr Ser Ala Tyr Phe Glu Ser Leu Val Glu Leu Val Ser Tyr Tyr 
705                 710                 715                 720 


Glu Lys His Ser Leu Tyr Arg Lys Met Arg Leu Arg Tyr Pro Val Thr 
                725                 730                 735     


Pro Glu Leu Leu Glu Arg Tyr Asn Met Glu Arg Asp Ile Asn Ser Leu 
            740                 745                 750         


Tyr Asp Val Ser Arg Met Tyr Val Asp Pro Ser Glu Ile Asn Pro Ser 
        755                 760                 765             


Met Pro Gln Arg Thr Val Lys Ala Leu Tyr Asp Tyr Lys Ala Lys Arg 
    770                 775                 780                 


Ser Asp Glu Leu Ser Phe Cys Arg Gly Ala Leu Ile His Asn Val Ser 
785                 790                 795                 800 


Lys Glu Pro Gly Gly Trp Trp Lys Gly Asp Tyr Gly Thr Arg Ile Gln 
                805                 810                 815     


Gln Tyr Phe Pro Ser Asn Tyr Val Glu Asp Ile Ser Thr Ala Asp Phe 
            820                 825                 830         


Glu Glu Leu Glu Lys Gln Ile Ile Glu Asp Asn Pro Leu Gly Ser Leu 
        835                 840                 845             


Cys Arg Gly Ile Leu Asp Leu Asn Thr Tyr Asn Val Val Lys Ala Pro 
    850                 855                 860                 


Gln Gly Lys Asn Gln Lys Ser Phe Val Phe Ile Leu Glu Pro Lys Gln 
865                 870                 875                 880 


Gln Gly Asp Pro Pro Val Glu Phe Ala Thr Asp Arg Val Glu Glu Leu 
                885                 890                 895     


Phe Glu Trp Phe Gln Ser Ile Arg Glu Ile Thr Trp Lys Ile Asp Thr 
            900                 905                 910         


Lys Glu Asn Asn Met Lys Tyr Trp Glu Lys Asn Gln Ser Ile Ala Ile 
        915                 920                 925             


Glu Leu Ser Asp Leu Val Val Tyr Cys Lys Pro Thr Ser Lys Thr Lys 
    930                 935                 940                 


Asp Asn Leu Glu Asn Pro Asp Phe Arg Glu Ile Arg Ser Phe Val Glu 
945                 950                 955                 960 


Thr Lys Ala Asp Ser Ile Ile Arg Gln Lys Pro Val Asp Leu Leu Lys 
                965                 970                 975     


Tyr Asn Gln Lys Gly Leu Thr Arg Val Tyr Pro Lys Gly Gln Arg Val 
            980                 985                 990         


Asp Ser Ser Asn Tyr Asp Pro Phe  Arg Leu Trp Leu Cys  Gly Ser Gln 
        995                 1000                 1005             


Met Val  Ala Leu Asn Phe Gln  Thr Ala Asp Lys Tyr  Met Gln Met 
    1010                 1015                 1020             


Asn His  Ala Leu Phe Ser Leu  Asn Gly Arg Thr Gly  Tyr Val Leu 
    1025                 1030                 1035             


Gln Pro  Glu Ser Met Arg Thr  Glu Lys Tyr Asp Pro  Met Pro Pro 
    1040                 1045                 1050             


Glu Ser  Gln Arg Lys Ile Leu  Met Thr Leu Thr Val  Lys Val Leu 
    1055                 1060                 1065             


Gly Ala  Arg His Leu Pro Lys  Leu Gly Arg Ser Ile  Ala Cys Pro 
    1070                 1075                 1080             


Phe Val  Glu Val Glu Ile Cys  Gly Ala Glu Tyr Asp  Asn Asn Lys 
    1085                 1090                 1095             


Phe Lys  Thr Thr Val Val Asn  Asp Asn Gly Leu Ser  Pro Ile Trp 
    1100                 1105                 1110             


Ala Pro  Thr Gln Glu Lys Val  Thr Phe Glu Ile Tyr  Asp Pro Asn 
    1115                 1120                 1125             


Leu Ala  Phe Leu Arg Phe Val  Val Tyr Glu Glu Asp  Met Phe Ser 
    1130                 1135                 1140             


Asp Pro  Asn Phe Leu Ala His  Ala Thr Tyr Pro Ile  Lys Ala Val 
    1145                 1150                 1155             


Lys Ser  Gly Phe Arg Ser Val  Pro Leu Lys Asn Gly  Tyr Ser Glu 
    1160                 1165                 1170             


Asp Ile  Glu Leu Ala Ser Leu  Leu Val Phe Cys Glu  Met Arg Pro 
    1175                 1180                 1185             


Val Leu  Glu Ser Glu Glu Glu  Leu Tyr Ser Ser Cys  Arg Gln Leu 
    1190                 1195                 1200             


Arg Arg  Arg Gln Glu Glu Leu  Asn Asn Gln Leu Phe  Leu Tyr Asp 
    1205                 1210                 1215             


Thr His  Gln Asn Leu Arg Asn  Ala Asn Arg Asp Ala  Leu Val Lys 
    1220                 1225                 1230             


Glu Phe  Ser Val Asn Glu Asn  Gln Leu Gln Leu Tyr  Gln Glu Lys 
    1235                 1240                 1245             


Cys Asn  Lys Arg Leu Arg Glu  Lys Arg Val Ser Asn  Ser Lys Phe 
    1250                 1255                 1260             


Tyr Ser  
    1265 


<210>  29
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Met Asp Thr Phe Thr Val Gln Asp Ser Thr Ala Met Ser Trp Trp Arg 
1               5                   10                  15      


Asn Asn Phe Trp Ile Ile Leu Ala Val Ala Ile Ile Val Val Ser Val 
            20                  25                  30          


Gly Leu Gly Leu Ile Leu Tyr Cys Val Cys Lys Trp Gln Leu Arg Arg 
        35                  40                  45              


Gly Lys Lys Trp Glu Ile Ala Lys Pro Leu Lys His Lys Gln Val Asp 
    50                  55                  60                  


Glu Glu Lys Met Tyr Glu Asn Val Leu Asn Glu Ser Pro Val Gln Leu 
65                  70                  75                  80  


Pro Pro Leu Pro Pro Arg Asn Trp Pro Ser Leu Glu Asp Ser Ser Pro 
                85                  90                  95      


Gln Glu Ala Pro Ser Gln Pro Pro Ala Thr Tyr Ser Leu Val Asn Lys 
            100                 105                 110         


Val Lys Asn Lys Lys Thr Val Ser Ile Pro Ser Tyr Ile Glu Pro Glu 
        115                 120                 125             


Asp Asp Tyr Asp Asp Val Glu Ile Pro Ala Asn Thr Glu Lys Ala Ser 
    130                 135                 140                 


Phe 
145 


<210>  30
<211>  1039
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Met Ala Val Gln Leu Val Pro Asp Ser Ala Leu Gly Leu Leu Met Met 
1               5                   10                  15      


Thr Glu Gly Arg Arg Cys Gln Val His Leu Leu Asp Asp Arg Lys Leu 
            20                  25                  30          


Glu Leu Leu Val Gln Pro Lys Leu Leu Ala Lys Glu Leu Leu Asp Leu 
        35                  40                  45              


Val Ala Ser His Phe Asn Leu Lys Glu Lys Glu Tyr Phe Gly Ile Ala 
    50                  55                  60                  


Phe Thr Asp Glu Thr Gly His Leu Asn Trp Leu Gln Leu Asp Arg Arg 
65                  70                  75                  80  


Val Leu Glu His Asp Phe Pro Lys Lys Ser Gly Pro Val Val Leu Tyr 
                85                  90                  95      


Phe Cys Val Arg Phe Tyr Ile Glu Ser Ile Ser Tyr Leu Lys Asp Asn 
            100                 105                 110         


Ala Thr Ile Glu Leu Phe Phe Leu Asn Ala Lys Ser Cys Ile Tyr Lys 
        115                 120                 125             


Glu Leu Ile Asp Val Asp Ser Glu Val Val Phe Glu Leu Ala Ser Tyr 
    130                 135                 140                 


Ile Leu Gln Glu Ala Lys Gly Asp Phe Ser Ser Asn Glu Val Val Arg 
145                 150                 155                 160 


Ser Asp Leu Lys Lys Leu Pro Ala Leu Pro Thr Gln Ala Leu Lys Glu 
                165                 170                 175     


His Pro Ser Leu Ala Tyr Cys Glu Asp Arg Val Ile Glu His Tyr Lys 
            180                 185                 190         


Lys Leu Asn Gly Gln Thr Arg Gly Gln Ala Ile Val Asn Tyr Met Ser 
        195                 200                 205             


Ile Val Glu Ser Leu Pro Thr Tyr Gly Val His Tyr Tyr Ala Val Lys 
    210                 215                 220                 


Asp Lys Gln Gly Ile Pro Trp Trp Leu Gly Leu Ser Tyr Lys Gly Ile 
225                 230                 235                 240 


Phe Gln Tyr Asp Tyr His Asp Lys Val Lys Pro Arg Lys Ile Phe Gln 
                245                 250                 255     


Trp Arg Gln Leu Glu Asn Leu Tyr Phe Arg Glu Lys Lys Phe Ser Val 
            260                 265                 270         


Glu Val His Asp Pro Arg Arg Ala Ser Val Thr Arg Arg Thr Phe Gly 
        275                 280                 285             


His Ser Gly Ile Ala Val His Thr Trp Tyr Ala Cys Pro Ala Leu Ile 
    290                 295                 300                 


Lys Ser Ile Trp Ala Met Ala Ile Ser Gln His Gln Phe Tyr Leu Asp 
305                 310                 315                 320 


Arg Lys Gln Ser Lys Ser Lys Ile His Ala Ala Arg Ser Leu Ser Glu 
                325                 330                 335     


Ile Ala Ile Asp Leu Thr Glu Thr Gly Thr Leu Lys Thr Ser Lys Leu 
            340                 345                 350         


Ala Asn Met Gly Ser Lys Gly Lys Ile Ile Ser Gly Ser Ser Gly Ser 
        355                 360                 365             


Leu Leu Ser Ser Gly Ser Gln Glu Ser Asp Ser Ser Gln Ser Ala Lys 
    370                 375                 380                 


Lys Asp Met Leu Ala Ala Leu Lys Ser Arg Gln Glu Ala Leu Glu Glu 
385                 390                 395                 400 


Thr Leu Arg Gln Arg Leu Glu Glu Leu Lys Lys Leu Cys Leu Arg Glu 
                405                 410                 415     


Ala Glu Leu Thr Gly Lys Leu Pro Val Glu Tyr Pro Leu Asp Pro Gly 
            420                 425                 430         


Glu Glu Pro Pro Ile Val Arg Arg Arg Ile Gly Thr Ala Phe Lys Leu 
        435                 440                 445             


Asp Glu Gln Lys Ile Leu Pro Lys Gly Glu Glu Ala Glu Leu Glu Arg 
    450                 455                 460                 


Leu Glu Arg Glu Phe Ala Ile Gln Ser Gln Ile Thr Glu Ala Ala Arg 
465                 470                 475                 480 


Arg Leu Ala Ser Asp Pro Asn Val Ser Lys Lys Leu Lys Lys Gln Arg 
                485                 490                 495     


Lys Thr Ser Tyr Leu Asn Ala Leu Lys Lys Leu Gln Glu Ile Glu Asn 
            500                 505                 510         


Ala Ile Asn Glu Asn Arg Ile Lys Ser Gly Lys Lys Pro Thr Gln Arg 
        515                 520                 525             


Ala Ser Leu Ile Ile Asp Asp Gly Asn Ile Ala Ser Glu Asp Ser Ser 
    530                 535                 540                 


Leu Ser Asp Ala Leu Val Leu Glu Asp Glu Asp Ser Gln Val Thr Ser 
545                 550                 555                 560 


Thr Ile Ser Pro Leu His Ser Pro His Lys Gly Leu Pro Pro Arg Pro 
                565                 570                 575     


Pro Ser His Asn Arg Pro Pro Pro Pro Gln Ser Leu Glu Gly Leu Arg 
            580                 585                 590         


Gln Met His Tyr His Arg Asn Asp Tyr Asp Lys Ser Pro Ile Lys Pro 
        595                 600                 605             


Lys Met Trp Ser Glu Ser Ser Leu Asp Glu Pro Tyr Glu Lys Val Lys 
    610                 615                 620                 


Lys Arg Ser Ser His Ser His Ser Ser Ser His Lys Arg Phe Pro Ser 
625                 630                 635                 640 


Thr Gly Ser Cys Ala Glu Ala Gly Gly Gly Ser Asn Ser Leu Gln Asn 
                645                 650                 655     


Ser Pro Ile Arg Gly Leu Pro His Trp Asn Ser Gln Ser Ser Met Pro 
            660                 665                 670         


Ser Thr Pro Asp Leu Arg Val Arg Ser Pro His Tyr Val His Ser Thr 
        675                 680                 685             


Arg Ser Val Asp Ile Ser Pro Thr Arg Leu His Ser Leu Ala Leu His 
    690                 695                 700                 


Phe Arg His Arg Ser Ser Ser Leu Glu Ser Gln Gly Lys Leu Leu Gly 
705                 710                 715                 720 


Ser Glu Asn Asp Thr Gly Ser Pro Asp Phe Tyr Thr Pro Arg Thr Arg 
                725                 730                 735     


Ser Ser Asn Gly Ser Asp Pro Met Asp Asp Cys Ser Ser Cys Thr Ser 
            740                 745                 750         


His Ser Ser Ser Glu His Tyr Tyr Pro Ala Gln Met Asn Ala Asn Tyr 
        755                 760                 765             


Ser Thr Leu Ala Glu Asp Ser Pro Ser Lys Ala Arg Gln Arg Gln Arg 
    770                 775                 780                 


Gln Arg Gln Arg Ala Ala Gly Ala Leu Gly Ser Ala Ser Ser Gly Ser 
785                 790                 795                 800 


Met Pro Asn Leu Ala Ala Arg Gly Gly Ala Gly Gly Ala Gly Gly Ala 
                805                 810                 815     


Gly Gly Gly Val Tyr Leu His Ser Gln Ser Gln Pro Ser Ser Gln Tyr 
            820                 825                 830         


Arg Ile Lys Glu Tyr Pro Leu Tyr Ile Glu Gly Gly Ala Thr Pro Val 
        835                 840                 845             


Val Val Arg Ser Leu Glu Ser Asp Gln Glu Gly His Tyr Ser Val Lys 
    850                 855                 860                 


Ala Gln Phe Lys Thr Ser Asn Ser Tyr Thr Ala Gly Gly Leu Phe Lys 
865                 870                 875                 880 


Glu Ser Trp Arg Gly Gly Gly Gly Asp Glu Gly Asp Thr Gly Arg Leu 
                885                 890                 895     


Thr Pro Ser Arg Ser Gln Ile Leu Arg Thr Pro Ser Leu Gly Arg Glu 
            900                 905                 910         


Gly Ala His Asp Lys Gly Ala Gly Arg Ala Ala Val Ser Asp Glu Leu 
        915                 920                 925             


Arg Gln Trp Tyr Gln Arg Ser Thr Ala Ser His Lys Glu His Ser Arg 
    930                 935                 940                 


Leu Ser His Thr Ser Ser Thr Ser Ser Asp Ser Gly Ser Gln Tyr Ser 
945                 950                 955                 960 


Thr Ser Ser Gln Ser Thr Phe Val Ala His Ser Arg Val Thr Arg Met 
                965                 970                 975     


Pro Gln Met Cys Lys Ala Thr Ser Ala Ala Leu Pro Gln Ser Gln Arg 
            980                 985                 990         


Ser Ser Thr Pro Ser Ser Glu Ile  Gly Ala Thr Pro Pro  Ser Ser Pro 
        995                 1000                 1005             


His His  Ile Leu Thr Trp Gln  Thr Gly Glu Ala Thr  Glu Asn Ser 
    1010                 1015                 1020             


Pro Ile  Leu Asp Gly Ser Glu  Ser Pro Pro His Gln  Ser Thr Asp 
    1025                 1030                 1035             


Glu 
    


<210>  31
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31

Met Gly Pro Gln Arg Arg Leu Ser Pro Ala Gly Ala Ala Leu Leu Trp 
1               5                   10                  15      


Gly Phe Leu Leu Gln Leu Thr Ala Ala Gln Glu Ala Ile Leu His Ala 
            20                  25                  30          


Ser Gly Asn Gly Thr Thr Lys Asp Tyr Cys Met Leu Tyr Asn Pro Tyr 
        35                  40                  45              


Trp Thr Ala Leu Pro Ser Thr Leu Glu Asn Ala Thr Ser Ile Ser Leu 
    50                  55                  60                  


Met Asn Leu Thr Ser Thr Pro Leu Cys Asn Leu Ser Asp Ile Pro Pro 
65                  70                  75                  80  


Val Gly Ile Lys Ser Lys Ala Val Val Val Pro Trp Gly Ser Cys His 
                85                  90                  95      


Phe Leu Glu Lys Ala Arg Ile Ala Gln Lys Gly Gly Ala Glu Ala Met 
            100                 105                 110         


Leu Val Val Asn Asn Ser Val Leu Phe Pro Pro Ser Gly Asn Arg Ser 
        115                 120                 125             


Glu Phe Pro Asp Val Lys Ile Leu Ile Ala Phe Ile Ser Tyr Lys Asp 
    130                 135                 140                 


Phe Arg Asp Met Asn Gln Thr Leu Gly Asp Asn Ile Thr Val Lys Met 
145                 150                 155                 160 


Tyr Ser Pro Ser Trp Pro Asn Phe Asp Tyr Thr Met Val Val Ile Phe 
                165                 170                 175     


Val Ile Ala Val Phe Thr Val Ala Leu Gly Gly Tyr Trp Ser Gly Leu 
            180                 185                 190         


Val Glu Leu Glu Asn Leu Lys Ala Val Thr Thr Glu Asp Arg Glu Met 
        195                 200                 205             


Arg Lys Lys Lys Glu Glu Tyr Leu Thr Phe Ser Pro Leu Thr Val Val 
    210                 215                 220                 


Ile Phe Val Val Ile Cys Cys Val Met Met Val Leu Leu Tyr Phe Phe 
225                 230                 235                 240 


Tyr Lys Trp Leu Val Tyr Val Met Ile Ala Ile Phe Cys Ile Ala Ser 
                245                 250                 255     


Ala Met Ser Leu Tyr Asn Cys Leu Ala Ala Leu Ile His Lys Ile Pro 
            260                 265                 270         


Tyr Gly Gln Cys Thr Ile Ala Cys Arg Gly Lys Asn Met Glu Val Arg 
        275                 280                 285             


Leu Ile Phe Leu Ser Gly Leu Cys Ile Ala Val Ala Val Val Trp Ala 
    290                 295                 300                 


Val Phe Arg Asn Glu Asp Arg Trp Ala Trp Ile Leu Gln Asp Ile Leu 
305                 310                 315                 320 


Gly Ile Ala Phe Cys Leu Asn Leu Ile Lys Thr Leu Lys Leu Pro Asn 
                325                 330                 335     


Phe Lys Ser Cys Val Ile Leu Leu Gly Leu Leu Leu Leu Tyr Asp Val 
            340                 345                 350         


Phe Phe Val Phe Ile Thr Pro Phe Ile Thr Lys Asn Gly Glu Ser Ile 
        355                 360                 365             


Met Val Glu Leu Ala Ala Gly Pro Phe Gly Asn Asn Glu Lys Leu Pro 
    370                 375                 380                 


Val Val Ile Arg Val Pro Lys Leu Ile Tyr Phe Ser Val Met Ser Val 
385                 390                 395                 400 


Cys Leu Met Pro Val Ser Ile Leu Gly Phe Gly Asp Ile Ile Val Pro 
                405                 410                 415     


Gly Leu Leu Ile Ala Tyr Cys Arg Arg Phe Asp Val Gln Thr Gly Ser 
            420                 425                 430         


Ser Tyr Ile Tyr Tyr Val Ser Ser Thr Val Ala Tyr Ala Ile Gly Met 
        435                 440                 445             


Ile Leu Thr Phe Val Val Leu Val Leu Met Lys Lys Gly Gln Pro Ala 
    450                 455                 460                 


Leu Leu Tyr Leu Val Pro Cys Thr Leu Ile Thr Ala Ser Val Val Ala 
465                 470                 475                 480 


Trp Arg Arg Lys Glu Met Lys Lys Phe Trp Lys Gly Asn Ser Tyr Gln 
                485                 490                 495     


Met Met Asp His Leu Asp Cys Ala Thr Asn Glu Glu Asn Pro Val Ile 
            500                 505                 510         


Ser Gly Glu Gln Ile Val Gln Gln 
        515                 520 


<210>  32
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Met Gly Thr Arg Leu Pro Leu Val Leu Arg Gln Leu Arg Arg Pro Pro 
1               5                   10                  15      


Gln Pro Pro Gly Pro Pro Arg Arg Leu Arg Val Pro Cys Arg Ala Ser 
            20                  25                  30          


Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Arg Glu Gly Leu Leu Gly 
        35                  40                  45              


Gln Arg Arg Pro Gln Asp Gly Gln Ala Arg Ser Ser Cys Ser Pro Gly 
    50                  55                  60                  


Gly Arg Thr Pro Ala Ala Arg Asp Ser Ile Val Arg Glu Val Ile Gln 
65                  70                  75                  80  


Asn Ser Lys Glu Val Leu Ser Leu Leu Gln Glu Lys Asn Pro Ala Phe 
                85                  90                  95      


Lys Pro Val Leu Ala Ile Ile Gln Ala Gly Asp Asp Asn Leu Met Gln 
            100                 105                 110         


Glu Ile Asn Gln Asn Leu Ala Glu Glu Ala Gly Leu Asn Ile Thr His 
        115                 120                 125             


Ile Cys Leu Pro Pro Asp Ser Ser Glu Ala Glu Ile Ile Asp Glu Ile 
    130                 135                 140                 


Leu Lys Ile Asn Glu Asp Thr Arg Val His Gly Leu Ala Leu Gln Ile 
145                 150                 155                 160 


Ser Glu Asn Leu Phe Ser Asn Lys Val Leu Asn Ala Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Val Asp Gly Val Thr Asp Ile Asn Leu Gly Lys Leu Val Arg 
            180                 185                 190         


Gly Asp Ala His Glu Cys Phe Val Ser Pro Val Ala Lys Ala Val Ile 
        195                 200                 205             


Glu Leu Leu Glu Lys Ser Gly Val Asn Leu Asp Gly Lys Lys Ile Leu 
    210                 215                 220                 


Val Val Gly Ala His Gly Ser Leu Glu Ala Ala Leu Gln Cys Leu Phe 
225                 230                 235                 240 


Gln Arg Lys Gly Ser Met Thr Met Ser Ile Gln Trp Lys Thr Arg Gln 
                245                 250                 255     


Leu Gln Ser Lys Leu His Glu Ala Asp Ile Val Val Leu Gly Ser Pro 
            260                 265                 270         


Lys Pro Glu Glu Ile Pro Leu Thr Trp Ile Gln Pro Gly Thr Thr Val 
        275                 280                 285             


Leu Asn Cys Ser His Asp Phe Leu Ser Gly Lys Val Gly Cys Gly Ser 
    290                 295                 300                 


Pro Arg Ile His Phe Gly Gly Leu Ile Glu Glu Asp Asp Val Ile Leu 
305                 310                 315                 320 


Leu Ala Ala Ala Leu Arg Ile Gln Asn Met Val Ser Ser Gly Arg Arg 
                325                 330                 335     


Trp Leu Arg Glu Gln Gln His Arg Arg Trp Arg Leu His Cys Leu Lys 
            340                 345                 350         


Leu Gln Pro Leu Ser Pro Val Pro Ser Asp Ile Glu Ile Ser Arg Gly 
        355                 360                 365             


Gln Thr Pro Lys Ala Val Asp Val Leu Ala Lys Glu Ile Gly Leu Leu 
    370                 375                 380                 


Ala Asp Glu Ile Glu Ile Tyr Gly Lys Ser Lys Ala Lys Val Arg Leu 
385                 390                 395                 400 


Ser Val Leu Glu Arg Leu Lys Asp Gln Ala Asp Gly Lys Tyr Val Leu 
                405                 410                 415     


Val Ala Gly Ile Thr Pro Thr Pro Leu Gly Glu Gly Lys Ser Thr Val 
            420                 425                 430         


Thr Ile Gly Leu Val Gln Ala Leu Thr Ala His Leu Asn Val Asn Ser 
        435                 440                 445             


Phe Ala Cys Leu Arg Gln Pro Ser Gln Gly Pro Thr Phe Gly Val Lys 
    450                 455                 460                 


Gly Gly Ala Ala Gly Gly Gly Tyr Ala Gln Val Ile Pro Met Glu Glu 
465                 470                 475                 480 


Phe Asn Leu His Leu Thr Gly Asp Ile His Ala Ile Thr Ala Ala Asn 
                485                 490                 495     


Asn Leu Leu Ala Ala Ala Ile Asp Thr Arg Ile Leu His Glu Asn Thr 
            500                 505                 510         


Gln Thr Asp Lys Ala Leu Tyr Asn Arg Leu Val Pro Leu Val Asn Gly 
        515                 520                 525             


Val Arg Glu Phe Ser Glu Ile Gln Leu Ala Arg Leu Lys Lys Leu Gly 
    530                 535                 540                 


Ile Asn Lys Thr Asp Pro Ser Thr Leu Thr Glu Glu Glu Val Ser Lys 
545                 550                 555                 560 


Phe Ala Arg Leu Asp Ile Asp Pro Ser Thr Ile Thr Trp Gln Arg Val 
                565                 570                 575     


Leu Asp Thr Asn Asp Arg Phe Leu Arg Lys Ile Thr Ile Gly Gln Gly 
            580                 585                 590         


Asn Thr Glu Lys Gly His Tyr Arg Gln Ala Gln Phe Asp Ile Ala Val 
        595                 600                 605             


Ala Ser Glu Ile Met Ala Val Leu Ala Leu Thr Asp Ser Leu Ala Asp 
    610                 615                 620                 


Met Lys Ala Arg Leu Gly Arg Met Val Val Ala Ser Asp Lys Ser Gly 
625                 630                 635                 640 


Gln Pro Val Thr Ala Asp Asp Leu Gly Val Thr Gly Ala Leu Thr Val 
                645                 650                 655     


Leu Met Lys Asp Ala Ile Lys Pro Asn Leu Met Gln Thr Leu Glu Gly 
            660                 665                 670         


Thr Pro Val Phe Val His Ala Gly Pro Phe Ala Asn Ile Ala His Gly 
        675                 680                 685             


Asn Ser Ser Val Leu Ala Asp Lys Ile Ala Leu Lys Leu Val Gly Glu 
    690                 695                 700                 


Glu Gly Phe Val Val Thr Glu Ala Gly Phe Gly Ala Asp Ile Gly Met 
705                 710                 715                 720 


Glu Lys Phe Phe Asn Ile Lys Cys Arg Ala Ser Gly Leu Val Pro Asn 
                725                 730                 735     


Val Val Val Leu Val Ala Thr Val Arg Ala Leu Lys Met His Gly Gly 
            740                 745                 750         


Gly Pro Ser Val Thr Ala Gly Val Pro Leu Lys Lys Glu Tyr Thr Glu 
        755                 760                 765             


Glu Asn Ile Gln Leu Val Ala Asp Gly Cys Cys Asn Leu Gln Lys Gln 
    770                 775                 780                 


Ile Gln Ile Thr Gln Leu Phe Gly Val Pro Val Val Val Ala Leu Asn 
785                 790                 795                 800 


Val Phe Lys Thr Asp Thr Arg Ala Glu Ile Asp Leu Val Cys Glu Leu 
                805                 810                 815     


Ala Lys Arg Ala Gly Ala Phe Asp Ala Val Pro Cys Tyr His Trp Ser 
            820                 825                 830         


Val Gly Gly Lys Gly Ser Val Asp Leu Ala Arg Ala Val Arg Glu Ala 
        835                 840                 845             


Ala Ser Lys Arg Ser Arg Phe Gln Phe Leu Tyr Asp Val Gln Val Pro 
    850                 855                 860                 


Ile Val Asp Lys Ile Arg Thr Ile Ala Gln Ala Val Tyr Gly Ala Lys 
865                 870                 875                 880 


Asp Ile Glu Leu Ser Pro Glu Ala Gln Ala Lys Ile Asp Arg Tyr Thr 
                885                 890                 895     


Gln Gln Gly Phe Gly Asn Leu Pro Ile Cys Met Ala Lys Thr His Leu 
            900                 905                 910         


Ser Leu Ser His Gln Pro Asp Lys Lys Gly Val Pro Arg Asp Phe Ile 
        915                 920                 925             


Leu Pro Ile Ser Asp Val Arg Ala Ser Ile Gly Ala Gly Phe Ile Tyr 
    930                 935                 940                 


Pro Leu Val Gly Thr Met Ser Thr Met Pro Gly Leu Pro Thr Arg Pro 
945                 950                 955                 960 


Cys Phe Tyr Asp Ile Asp Leu Asp Thr Glu Thr Glu Gln Val Lys Gly 
                965                 970                 975     


Leu Phe 
        


<210>  33
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33

Met Asp Ser Arg Ala Gln Leu Trp Gly Leu Ala Leu Asn Lys Arg Arg 
1               5                   10                  15      


Ala Thr Leu Pro His Pro Gly Gly Ser Thr Asn Leu Lys Ala Asp Pro 
            20                  25                  30          


Glu Glu Leu Phe Thr Lys Leu Glu Lys Ile Gly Lys Gly Ser Phe Gly 
        35                  40                  45              


Glu Val Phe Lys Gly Ile Asp Asn Arg Thr Gln Lys Val Val Ala Ile 
    50                  55                  60                  


Lys Ile Ile Asp Leu Glu Glu Ala Glu Asp Glu Ile Glu Asp Ile Gln 
65                  70                  75                  80  


Gln Glu Ile Thr Val Leu Ser Gln Cys Asp Ser Pro Tyr Val Thr Lys 
                85                  90                  95      


Tyr Tyr Gly Ser Tyr Leu Lys Asp Thr Lys Leu Trp Ile Ile Met Glu 
            100                 105                 110         


Tyr Leu Gly Gly Gly Ser Ala Leu Asp Leu Leu Glu Pro Gly Pro Leu 
        115                 120                 125             


Asp Glu Thr Gln Ile Ala Thr Ile Leu Arg Glu Ile Leu Lys Gly Leu 
    130                 135                 140                 


Asp Tyr Leu His Ser Glu Lys Lys Ile His Arg Asp Ile Lys Ala Ala 
145                 150                 155                 160 


Asn Val Leu Leu Ser Glu His Gly Glu Val Lys Leu Ala Asp Phe Gly 
                165                 170                 175     


Val Ala Gly Gln Leu Thr Asp Thr Gln Ile Lys Arg Asn Thr Phe Val 
            180                 185                 190         


Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Lys Gln Ser Ala Tyr 
        195                 200                 205             


Asp Ser Lys Ala Asp Ile Trp Ser Leu Gly Ile Thr Ala Ile Glu Leu 
    210                 215                 220                 


Ala Arg Gly Glu Pro Pro His Ser Glu Leu His Pro Met Lys Val Leu 
225                 230                 235                 240 


Phe Leu Ile Pro Lys Asn Asn Pro Pro Thr Leu Glu Gly Asn Tyr Ser 
                245                 250                 255     


Lys Pro Leu Lys Glu Phe Val Glu Ala Cys Leu Asn Lys Glu Pro Ser 
            260                 265                 270         


Phe Arg Pro Thr Ala Lys Glu Leu Leu Lys His Lys Phe Ile Leu Arg 
        275                 280                 285             


Asn Ala Lys Lys Thr Ser Tyr Leu Thr Glu Leu Ile Asp Arg Tyr Lys 
    290                 295                 300                 


Arg Trp Lys Ala Glu Gln Ser His Asp Asp Ser Ser Ser Glu Asp Ser 
305                 310                 315                 320 


Asp Ala Glu Thr Asp Gly Gln Ala Ser Gly Gly Ser Asp Ser Gly Asp 
                325                 330                 335     


Trp Ile Phe Thr Ile Arg Glu Lys Asp Pro Lys Asn Leu Glu Asn Gly 
            340                 345                 350         


Ala Leu Gln Pro Ser Asp Leu Asp Arg Asn Lys Met Lys Asp Ile Pro 
        355                 360                 365             


Lys Arg Pro Phe Ser Gln Cys Leu Ser Thr Ile Ile Ser Pro Leu Phe 
    370                 375                 380                 


Ala Glu Leu Lys Glu Lys Ser Gln Ala Cys Gly Gly Asn Leu Gly Ser 
385                 390                 395                 400 


Ile Glu Glu Leu Arg Gly Ala Ile Tyr Leu Ala Glu Glu Ala Cys Pro 
                405                 410                 415     


Gly Ile Ser Asp Thr Met Val Ala Gln Leu Val Gln Arg Leu Gln Arg 
            420                 425                 430         


Tyr Ser Leu Ser Gly Gly Gly Thr Ser Ser His 
        435                 440             


<210>  34
<211>  854
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Met Pro Gly Gly Gly Pro Gln Gly Ala Pro Ala Ala Ala Gly Gly Gly 
1               5                   10                  15      


Gly Val Ser His Arg Ala Gly Ser Arg Asp Cys Leu Pro Pro Ala Ala 
            20                  25                  30          


Cys Phe Arg Arg Arg Arg Leu Ala Arg Arg Pro Gly Tyr Met Arg Ser 
        35                  40                  45              


Ser Thr Gly Pro Gly Ile Gly Phe Leu Ser Pro Ala Val Gly Thr Leu 
    50                  55                  60                  


Phe Arg Phe Pro Gly Gly Val Ser Gly Glu Glu Ser His His Ser Glu 
65                  70                  75                  80  


Ser Arg Ala Arg Gln Cys Gly Leu Asp Ser Arg Gly Leu Leu Val Arg 
                85                  90                  95      


Ser Pro Val Ser Lys Ser Ala Ala Ala Pro Thr Val Thr Ser Val Arg 
            100                 105                 110         


Gly Thr Ser Ala His Phe Gly Ile Gln Leu Arg Gly Gly Thr Arg Leu 
        115                 120                 125             


Pro Asp Arg Leu Ser Trp Pro Cys Gly Pro Gly Ser Ala Gly Trp Gln 
    130                 135                 140                 


Gln Glu Phe Ala Ala Met Asp Ser Ser Glu Thr Leu Asp Ala Ser Trp 
145                 150                 155                 160 


Glu Ala Ala Cys Ser Asp Gly Ala Arg Arg Val Arg Ala Ala Gly Ser 
                165                 170                 175     


Leu Pro Ser Ala Glu Leu Ser Ser Asn Ser Cys Ser Pro Gly Cys Gly 
            180                 185                 190         


Pro Glu Val Pro Pro Thr Pro Pro Gly Ser His Ser Ala Phe Thr Ser 
        195                 200                 205             


Ser Phe Ser Phe Ile Arg Leu Ser Leu Gly Ser Ala Gly Glu Arg Gly 
    210                 215                 220                 


Glu Ala Glu Gly Cys Pro Pro Ser Arg Glu Ala Glu Ser His Cys Gln 
225                 230                 235                 240 


Ser Pro Gln Glu Met Gly Ala Lys Ala Ala Ser Leu Asp Gly Pro His 
                245                 250                 255     


Glu Asp Pro Arg Cys Leu Ser Arg Pro Phe Ser Leu Leu Ala Thr Arg 
            260                 265                 270         


Val Ser Ala Asp Leu Ala Gln Ala Ala Arg Asn Ser Ser Arg Pro Glu 
        275                 280                 285             


Arg Asp Met His Ser Leu Pro Asp Met Asp Pro Gly Ser Ser Ser Ser 
    290                 295                 300                 


Leu Asp Pro Ser Leu Ala Gly Cys Gly Gly Asp Gly Ser Ser Gly Ser 
305                 310                 315                 320 


Gly Asp Ala His Ser Trp Asp Thr Leu Leu Arg Lys Trp Glu Pro Val 
                325                 330                 335     


Leu Arg Asp Cys Leu Leu Arg Asn Arg Arg Gln Met Glu Val Ile Ser 
            340                 345                 350         


Leu Arg Leu Lys Leu Gln Lys Leu Gln Glu Asp Ala Val Glu Asn Asp 
        355                 360                 365             


Asp Tyr Asp Lys Ala Glu Thr Leu Gln Gln Arg Leu Glu Asp Leu Glu 
    370                 375                 380                 


Gln Glu Lys Ile Ser Leu His Phe Gln Leu Pro Ser Arg Gln Pro Ala 
385                 390                 395                 400 


Leu Ser Ser Phe Leu Gly His Leu Ala Ala Gln Val Gln Ala Ala Leu 
                405                 410                 415     


Arg Arg Gly Ala Thr Gln Gln Ala Ser Gly Asp Asp Thr His Thr Pro 
            420                 425                 430         


Leu Arg Met Glu Pro Arg Leu Leu Glu Pro Thr Ala Gln Asp Ser Leu 
        435                 440                 445             


His Val Ser Ile Thr Arg Arg Asp Trp Leu Leu Gln Glu Lys Gln Gln 
    450                 455                 460                 


Leu Gln Lys Glu Ile Glu Ala Leu Gln Ala Arg Met Phe Val Leu Glu 
465                 470                 475                 480 


Ala Lys Asp Gln Gln Leu Arg Arg Glu Ile Glu Glu Gln Glu Gln Gln 
                485                 490                 495     


Leu Gln Trp Gln Gly Cys Asp Leu Thr Pro Leu Val Gly Gln Leu Ser 
            500                 505                 510         


Leu Gly Gln Leu Gln Glu Val Ser Lys Ala Leu Gln Asp Thr Leu Ala 
        515                 520                 525             


Ser Ala Gly Gln Ile Pro Phe His Ala Glu Pro Pro Glu Thr Ile Arg 
    530                 535                 540                 


Ser Leu Gln Glu Arg Ile Lys Ser Leu Asn Leu Ser Leu Lys Glu Ile 
545                 550                 555                 560 


Thr Thr Lys Val Cys Met Ser Glu Lys Phe Cys Ser Thr Leu Arg Lys 
                565                 570                 575     


Lys Val Asn Asp Ile Glu Thr Gln Leu Pro Ala Leu Leu Glu Ala Lys 
            580                 585                 590         


Met His Ala Ile Ser Gly Asn His Phe Trp Thr Ala Lys Asp Leu Thr 
        595                 600                 605             


Glu Glu Ile Arg Ser Leu Thr Ser Glu Arg Glu Gly Leu Glu Gly Leu 
    610                 615                 620                 


Leu Ser Lys Leu Leu Val Leu Ser Ser Arg Asn Val Lys Lys Leu Gly 
625                 630                 635                 640 


Ser Val Lys Glu Asp Tyr Asn Arg Leu Arg Arg Glu Val Glu His Gln 
                645                 650                 655     


Glu Thr Ala Tyr Glu Thr Ser Val Lys Glu Asn Thr Met Lys Tyr Met 
            660                 665                 670         


Glu Thr Leu Lys Asn Lys Leu Cys Ser Cys Lys Cys Pro Leu Leu Gly 
        675                 680                 685             


Lys Val Trp Glu Ala Asp Leu Glu Ala Cys Arg Leu Leu Ile Gln Ser 
    690                 695                 700                 


Leu Gln Leu Gln Glu Ala Arg Gly Ser Leu Ser Val Glu Asp Glu Arg 
705                 710                 715                 720 


Gln Met Asp Asp Leu Glu Gly Ala Ala Pro Pro Ile Pro Pro Arg Leu 
                725                 730                 735     


His Ser Glu Asp Lys Arg Lys Thr Pro Leu Lys Val Leu Glu Glu Trp 
            740                 745                 750         


Lys Thr His Leu Ile Pro Ser Leu His Cys Ala Gly Gly Glu Gln Lys 
        755                 760                 765             


Glu Glu Ser Tyr Ile Leu Ser Ala Glu Leu Gly Glu Lys Cys Glu Asp 
    770                 775                 780                 


Ile Gly Lys Lys Leu Leu Tyr Leu Glu Asp Gln Leu His Thr Ala Ile 
785                 790                 795                 800 


His Ser His Asp Glu Asp Leu Ile Gln Ser Leu Arg Arg Glu Leu Gln 
                805                 810                 815     


Met Val Lys Glu Thr Leu Gln Ala Met Ile Leu Gln Leu Gln Pro Ala 
            820                 825                 830         


Lys Glu Ala Gly Glu Arg Glu Ala Ala Ala Ser Cys Met Thr Ala Gly 
        835                 840                 845             


Val His Glu Ala Gln Ala 
    850                 


<210>  35
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Met Ala Ala Ser Ala Gly Ala Gly Ala Val Ile Ala Ala Pro Asp Ser 
1               5                   10                  15      


Arg Arg Trp Leu Trp Ser Val Leu Ala Ala Ala Leu Gly Leu Leu Thr 
            20                  25                  30          


Ala Gly Val Ser Ala Leu Glu Val Tyr Thr Pro Lys Glu Ile Phe Val 
        35                  40                  45              


Ala Asn Gly Thr Gln Gly Lys Leu Thr Cys Lys Phe Lys Ser Thr Ser 
    50                  55                  60                  


Thr Thr Gly Gly Leu Thr Ser Val Ser Trp Ser Phe Gln Pro Glu Gly 
65                  70                  75                  80  


Ala Asp Thr Thr Val Ser Phe Phe His Tyr Ser Gln Gly Gln Val Tyr 
                85                  90                  95      


Leu Gly Asn Tyr Pro Pro Phe Lys Asp Arg Ile Ser Trp Ala Gly Asp 
            100                 105                 110         


Leu Asp Lys Lys Asp Ala Ser Ile Asn Ile Glu Asn Met Gln Phe Ile 
        115                 120                 125             


His Asn Gly Thr Tyr Ile Cys Asp Val Lys Asn Pro Pro Asp Ile Val 
    130                 135                 140                 


Val Gln Pro Gly His Ile Arg Leu Tyr Val Val Glu Lys Glu Asn Leu 
145                 150                 155                 160 


Pro Val Phe Pro Val Trp Val Val Val Gly Ile Val Thr Ala Val Val 
                165                 170                 175     


Leu Gly Leu Thr Leu Leu Ile Ser Met Ile Leu Ala Val Leu Tyr Arg 
            180                 185                 190         


Arg Lys Asn Ser Lys Arg Asp Tyr Thr Gly Cys Ser Thr Ser Glu Ser 
        195                 200                 205             


Leu Ser Pro Val Lys Gln Ala Pro Arg Lys Ser Pro Ser Asp Thr Glu 
    210                 215                 220                 


Gly Leu Val Lys Ser Leu Pro Ser Gly Ser His Gln Gly Pro Val Ile 
225                 230                 235                 240 


Tyr Ala Gln Leu Asp His Ser Gly Gly His His Ser Asp Lys Ile Asn 
                245                 250                 255     


Lys Ser Glu Ser Val Val Tyr Ala Asp Ile Arg Lys Asn 
            260                 265                 


<210>  36
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Met Leu Ala Pro Leu Arg Asn Ala Pro Gly Arg Glu Gly Ala Thr Ser 
1               5                   10                  15      


Pro Ser Pro Pro Thr Asp Ala Thr Gly Ser Leu Gly Glu Trp Asp Val 
            20                  25                  30          


Asp Arg Asn Val Lys Thr Glu Gly Trp Val Ser Lys Glu Arg Ile Ser 
        35                  40                  45              


Lys Leu His Arg Leu Arg Met Ala Asp Ile Leu Ser Gln Ser Glu Thr 
    50                  55                  60                  


Leu Ala Ser Gln Asp Leu Ser Gly Asp Phe Lys Lys Pro Ala Leu Pro 
65                  70                  75                  80  


Val Ser Pro Ala Ala Arg Ser Lys Ala Pro Ala Ser Ser Ser Ser Asn 
                85                  90                  95      


Pro Glu Glu Val Gln Lys Glu Gly Pro Thr Ala Leu Gln Asp Ser Asn 
            100                 105                 110         


Ser Gly Glu Pro Asp Ile Pro Pro Pro Gln Pro Asp Cys Gly Asp Phe 
        115                 120                 125             


Arg Ser Leu Gln Glu Glu Gln Ser Arg Pro Pro Thr Ala Val Ser Ser 
    130                 135                 140                 


Pro Gly Gly Pro Ala Arg Ala Pro Pro Tyr Gln Glu Pro Pro Trp Gly 
145                 150                 155                 160 


Gly Pro Ala Thr Ala Pro Tyr Ser Leu Glu Thr Leu Lys Gly Gly Thr 
                165                 170                 175     


Ile Leu Gly Thr Arg Ser Leu Lys Gly Thr Ser Tyr Cys Leu Phe Gly 
            180                 185                 190         


Arg Leu Ser Gly Cys Asp Val Cys Leu Glu His Pro Ser Val Ser Arg 
        195                 200                 205             


Tyr His Ala Val Leu Gln His Arg Ala Ser Gly Pro Asp Gly Glu Cys 
    210                 215                 220                 


Asp Ser Asn Gly Pro Gly Phe Tyr Leu Tyr Asp Leu Gly Ser Thr His 
225                 230                 235                 240 


Gly Thr Phe Leu Asn Lys Thr Arg Ile Pro Pro Arg Thr Tyr Cys Arg 
                245                 250                 255     


Val His Val Gly His Val Val Arg Phe Gly Gly Ser Thr Arg Leu Phe 
            260                 265                 270         


Ile Leu Gln Gly Pro Glu Glu Asp Arg Glu Ala Glu Ser Glu Leu Thr 
        275                 280                 285             


Val Thr Gln Leu Lys Glu Leu Arg Lys Gln Gln Gln Ile Leu Leu Glu 
    290                 295                 300                 


Lys Lys Met Leu Gly Glu Asp Ser Asp Glu Glu Glu Glu Met Asp Thr 
305                 310                 315                 320 


Ser Glu Arg Lys Ile Asn Ala Gly Ser Gln Asp Asp Glu Met Gly Cys 
                325                 330                 335     


Thr Trp Gly Met Gly Glu Asp Ala Val Glu Asp Asp Ala Glu Glu Asn 
            340                 345                 350         


Pro Ile Val Leu Glu Phe Gln Gln Glu Arg Glu Ala Phe Tyr Ile Lys 
        355                 360                 365             


Asp Pro Lys Lys Ala Leu Gln Gly Phe Phe Asp Arg Glu Gly Glu Glu 
    370                 375                 380                 


Leu Glu Tyr Glu Phe Asp Glu Gln Gly His Ser Thr Trp Leu Cys Arg 
385                 390                 395                 400 


Val Arg Leu Pro Val Asp Asp Ser Thr Gly Lys Gln Leu Val Ala Glu 
                405                 410                 415     


Ala Ile His Ser Gly Lys Lys Lys Glu Ala Met Ile Gln Cys Ser Leu 
            420                 425                 430         


Glu Ala Cys Arg Ile Leu Asp Thr Leu Gly Leu Leu Arg Gln Glu Ala 
        435                 440                 445             


Val Ser Arg Lys Arg Lys Ala Lys Asn Trp Glu Asp Glu Asp Phe Tyr 
    450                 455                 460                 


Asp Ser Asp Asp Asp Thr Phe Leu Asp Arg Thr Gly Leu Ile Glu Lys 
465                 470                 475                 480 


Lys Arg Leu Asn Arg Met Lys Lys Ala Gly Lys Ile Asp Glu Lys Pro 
                485                 490                 495     


Glu Thr Phe Glu Ser Leu Val Ala Lys Leu Asn Asp Ala Glu Arg Glu 
            500                 505                 510         


Leu Ser Glu Ile Ser Glu Arg Leu Lys Ala Ser Ser Gln Val Leu Ser 
        515                 520                 525             


Glu Ser Pro Ser Gln Asp Ser Leu Asp Ala Phe Met Ser Glu Met Lys 
    530                 535                 540                 


Ser Gly Ser Thr Leu Asp Gly Val Ser Arg Lys Lys Leu His Leu Arg 
545                 550                 555                 560 


Thr Phe Glu Leu Arg Lys Glu Gln Gln Arg Leu Lys Gly Leu Ile Lys 
                565                 570                 575     


Ile Val Lys Pro Ala Glu Ile Pro Glu Leu Lys Lys Thr Glu Thr Gln 
            580                 585                 590         


Thr Thr Gly Ala Glu Asn Lys Ala Lys Lys Leu Thr Leu Pro Leu Phe 
        595                 600                 605             


Gly Ala Met Lys Gly Gly Ser Lys Phe Lys Leu Lys Thr Gly Thr Val 
    610                 615                 620                 


Gly Lys Leu Pro Pro Lys Arg Pro Glu Leu Pro Pro Thr Leu Met Arg 
625                 630                 635                 640 


Met Lys Asp Glu Pro Glu Val Glu Glu Glu Glu Glu Glu Glu Glu Glu 
                645                 650                 655     


Glu Glu Lys Glu Lys Glu Glu His Glu Lys Lys Lys Leu Glu Asp Gly 
            660                 665                 670         


Ser Leu Ser Arg Pro Gln Pro Glu Ile Glu Pro Glu Ala Ala Val Gln 
        675                 680                 685             


Glu Met Arg Pro Pro Thr Asp Leu Thr His Phe Lys Glu Thr Gln Thr 
    690                 695                 700                 


His Glu Asn Met Ser Gln Leu Ser Glu Glu Glu Gln Asn Lys Asp Tyr 
705                 710                 715                 720 


Gln Asp Cys Ser Lys Thr Thr Ser Leu Cys Ala Gly Pro Ser Ala Ser 
                725                 730                 735     


Lys Asn Glu Tyr Glu Lys Ser Arg Gly Glu Leu Lys Lys Lys Lys Thr 
            740                 745                 750         


Pro Gly Pro Gly Lys Leu Pro Pro Thr Leu Ser Ser Lys Tyr Pro Glu 
        755                 760                 765             


Asp Asp Pro Asp Tyr Cys Val Trp Val Pro Pro Glu Gly Gln Ser Gly 
    770                 775                 780                 


Asp Gly Arg Thr His Leu Asn Asp Lys Tyr Gly Tyr 
785                 790                 795     


<210>  37
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Met Ala Val Ala Gly Ala Val Ser Gly Glu Pro Leu Val His Trp Cys 
1               5                   10                  15      


Thr Gln Gln Leu Arg Lys Thr Phe Gly Leu Asp Val Ser Glu Glu Ile 
            20                  25                  30          


Ile Gln Tyr Val Leu Ser Ile Glu Ser Ala Glu Glu Ile Arg Glu Tyr 
        35                  40                  45              


Val Thr Asp Leu Leu Gln Gly Asn Glu Gly Lys Lys Gly Gln Phe Ile 
    50                  55                  60                  


Glu Glu Leu Ile Thr Lys Trp Gln Lys Asn Asp Gln Glu Leu Ile Ser 
65                  70                  75                  80  


Asp Pro Leu Gln Gln Cys Phe Lys Lys Asp Glu Ile Leu Asp Gly Gln 
                85                  90                  95      


Lys Ser Gly Asp His Leu Lys Arg Gly Arg Lys Lys Gly Arg Asn Arg 
            100                 105                 110         


Gln Glu Val Pro Ala Phe Thr Glu Pro Asp Thr Thr Ala Glu Val Lys 
        115                 120                 125             


Thr Pro Phe Asp Leu Ala Lys Ala Gln Glu Asn Ser Asn Ser Val Lys 
    130                 135                 140                 


Lys Lys Thr Lys Phe Val Asn Leu Tyr Thr Arg Glu Gly Gln Asp Arg 
145                 150                 155                 160 


Leu Ala Val Leu Leu Pro Gly Arg His Pro Cys Asp Cys Leu Gly Gln 
                165                 170                 175     


Lys His Lys Leu Ile Asn Asn Cys Leu Ile Cys Gly Arg Ile Val Cys 
            180                 185                 190         


Glu Gln Glu Gly Ser Gly Pro Cys Leu Phe Cys Gly Thr Leu Val Cys 
        195                 200                 205             


Thr His Glu Glu Gln Asp Ile Leu Gln Arg Asp Ser Asn Lys Ser Gln 
    210                 215                 220                 


Lys Leu Leu Lys Lys Leu Met Ser Gly Val Glu Asn Ser Gly Lys Val 
225                 230                 235                 240 


Asp Ile Ser Thr Lys Asp Leu Leu Pro His Gln Glu Leu Arg Ile Lys 
                245                 250                 255     


Ser Gly Leu Glu Lys Ala Ile Lys His Lys Asp Lys Leu Leu Glu Phe 
            260                 265                 270         


Asp Arg Thr Ser Ile Arg Arg Thr Gln Val Ile Asp Asp Glu Ser Asp 
        275                 280                 285             


Tyr Phe Ala Ser Asp Ser Asn Gln Trp Leu Ser Lys Leu Glu Arg Glu 
    290                 295                 300                 


Thr Leu Gln Lys Arg Glu Glu Glu Leu Arg Glu Leu Arg His Ala Ser 
305                 310                 315                 320 


Arg Leu Ser Lys Lys Val Thr Ile Asp Phe Ala Gly Arg Lys Ile Leu 
                325                 330                 335     


Glu Glu Glu Asn Ser Leu Ala Glu Tyr His Ser Arg Leu Asp Glu Thr 
            340                 345                 350         


Ile Gln Ala Ile Ala Asn Gly Thr Leu Asn Gln Pro Leu Thr Lys Leu 
        355                 360                 365             


Asp Arg Ser Ser Glu Glu Pro Leu Gly Val Leu Val Asn Pro Asn Met 
    370                 375                 380                 


Tyr Gln Ser Pro Pro Gln Trp Val Asp His Thr Gly Ala Ala Ser Gln 
385                 390                 395                 400 


Lys Lys Ala Phe Arg Ser Ser Gly Phe Gly Leu Glu Phe Asn Ser Phe 
                405                 410                 415     


Gln His Gln Leu Arg Ile Gln Asp Gln Glu Phe Gln Glu Gly Phe Asp 
            420                 425                 430         


Gly Gly Trp Cys Leu Ser Val His Gln Pro Trp Ala Ser Leu Leu Val 
        435                 440                 445             


Arg Gly Ile Lys Arg Val Glu Gly Arg Ser Trp Tyr Thr Pro His Arg 
    450                 455                 460                 


Gly Arg Leu Trp Ile Ala Ala Thr Ala Lys Lys Pro Ser Pro Gln Glu 
465                 470                 475                 480 


Val Ser Glu Leu Gln Ala Thr Tyr Arg Leu Leu Arg Gly Lys Asp Val 
                485                 490                 495     


Glu Phe Pro Asn Asp Tyr Pro Ser Gly Cys Leu Leu Gly Cys Val Asp 
            500                 505                 510         


Leu Ile Asp Cys Leu Ser Gln Lys Gln Phe Lys Glu Gln Phe Pro Asp 
        515                 520                 525             


Ile Ser Gln Glu Ser Asp Ser Pro Phe Val Phe Ile Cys Lys Asn Pro 
    530                 535                 540                 


Gln Glu Met Val Val Lys Phe Pro Ile Lys Gly Asn Pro Lys Ile Trp 
545                 550                 555                 560 


Lys Leu Asp Ser Lys Ile His Gln Gly Ala Lys Lys Gly Leu Met Lys 
                565                 570                 575     


Gln Asn Lys Ala Val 
            580     


<210>  38
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Met Leu Ser Ala Thr Arg Arg Ala Cys Gln Leu Leu Leu Leu His Ser 
1               5                   10                  15      


Leu Phe Pro Val Pro Arg Met Gly Asn Ser Ala Ser Asn Ile Val Ser 
            20                  25                  30          


Pro Gln Glu Ala Leu Pro Gly Arg Lys Glu Gln Thr Pro Val Ala Ala 
        35                  40                  45              


Lys His His Val Asn Gly Asn Arg Thr Val Glu Pro Phe Pro Glu Gly 
    50                  55                  60                  


Thr Gln Met Ala Val Phe Gly Met Gly Cys Phe Trp Gly Ala Glu Arg 
65                  70                  75                  80  


Lys Phe Trp Val Leu Lys Gly Val Tyr Ser Thr Gln Val Gly Phe Ala 
                85                  90                  95      


Gly Gly Tyr Thr Ser Asn Pro Thr Tyr Lys Glu Val Cys Ser Glu Lys 
            100                 105                 110         


Thr Gly His Ala Glu Val Val Arg Val Val Tyr Gln Pro Glu His Met 
        115                 120                 125             


Ser Phe Glu Glu Leu Leu Lys Val Phe Trp Glu Asn His Asp Pro Thr 
    130                 135                 140                 


Gln Gly Met Arg Gln Gly Asn Asp His Gly Thr Gln Tyr Arg Ser Ala 
145                 150                 155                 160 


Ile Tyr Pro Thr Ser Ala Lys Gln Met Glu Ala Ala Leu Ser Ser Lys 
                165                 170                 175     


Glu Asn Tyr Gln Lys Val Leu Ser Glu His Gly Phe Gly Pro Ile Thr 
            180                 185                 190         


Thr Asp Ile Arg Glu Gly Gln Thr Phe Tyr Tyr Ala Glu Asp Tyr His 
        195                 200                 205             


Gln Gln Tyr Leu Ser Lys Asn Pro Asn Gly Tyr Cys Gly Leu Gly Gly 
    210                 215                 220                 


Thr Gly Val Ser Cys Pro Val Gly Ile Lys Lys 
225                 230                 235 


<210>  39
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Met Ala Ala Leu Leu Leu Gly Ala Val Leu Leu Val Ala Gln Pro Gln 
1               5                   10                  15      


Leu Val Pro Ser Arg Pro Ala Glu Leu Gly Gln Gln Glu Leu Leu Arg 
            20                  25                  30          


Lys Ala Gly Thr Leu Gln Asp Asp Val Arg Asp Gly Val Ala Pro Asn 
        35                  40                  45              


Gly Ser Ala Gln Gln Leu Pro Gln Thr Ile Ile Ile Gly Val Arg Lys 
    50                  55                  60                  


Gly Gly Thr Arg Ala Leu Leu Glu Met Leu Ser Leu His Pro Asp Val 
65                  70                  75                  80  


Ala Ala Ala Glu Asn Glu Val His Phe Phe Asp Trp Glu Glu His Tyr 
                85                  90                  95      


Ser His Gly Leu Gly Trp Tyr Leu Ser Gln Met Pro Phe Ser Trp Pro 
            100                 105                 110         


His Gln Leu Thr Val Glu Lys Thr Pro Ala Tyr Phe Thr Ser Pro Lys 
        115                 120                 125             


Val Pro Glu Arg Val Tyr Ser Met Asn Pro Ser Ile Arg Leu Leu Leu 
    130                 135                 140                 


Ile Leu Arg Asp Pro Ser Glu Arg Val Leu Ser Asp Tyr Thr Gln Val 
145                 150                 155                 160 


Phe Tyr Asn His Met Gln Lys His Lys Pro Tyr Pro Ser Ile Glu Glu 
                165                 170                 175     


Phe Leu Val Arg Asp Gly Arg Leu Asn Val Asp Tyr Lys Ala Leu Asn 
            180                 185                 190         


Arg Ser Leu Tyr His Val His Met Gln Asn Trp Leu Arg Phe Phe Pro 
        195                 200                 205             


Leu Arg His Ile His Ile Val Asp Gly Asp Arg Leu Ile Arg Asp Pro 
    210                 215                 220                 


Phe Pro Glu Ile Gln Lys Val Glu Arg Phe Leu Lys Leu Ser Pro Gln 
225                 230                 235                 240 


Ile Asn Ala Ser Asn Phe Tyr Phe Asn Lys Thr Lys Gly Phe Tyr Cys 
                245                 250                 255     


Leu Arg Asp Ser Gly Arg Asp Arg Cys Leu His Glu Ser Lys Gly Arg 
            260                 265                 270         


Ala His Pro Gln Val Asp Pro Lys Leu Leu Asn Lys Leu His Glu Tyr 
        275                 280                 285             


Phe His Glu Pro Asn Lys Lys Phe Phe Glu Leu Val Gly Arg Thr Phe 
    290                 295                 300                 


Asp Trp His 
305         


<210>  40
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Met Thr Thr Phe Lys Glu Ala Met Thr Phe Lys Asp Val Ala Val Val 
1               5                   10                  15      


Phe Thr Glu Glu Glu Leu Gly Leu Leu Asp Leu Ala Gln Arg Lys Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Phe Arg Asn Leu Leu Ser Val Gly 
        35                  40                  45              


His Gln Ala Phe His Arg Asp Thr Phe His Phe Leu Arg Glu Glu Lys 
    50                  55                  60                  


Ile Trp Met Met Lys Thr Ala Ile Gln Arg Glu Gly Asn Ser Gly Asp 
65                  70                  75                  80  


Lys Ile Gln Thr Glu Met Glu Thr Val Ser Glu Ala Gly Thr His Gln 
                85                  90                  95      


Glu Trp Ser Phe Gln Gln Ile Trp Glu Lys Ile Ala Ser Asp Leu Thr 
            100                 105                 110         


Arg Ser Gln Asp Leu Met Ile Asn Ser Ser Gln Phe Ser Lys Glu Gly 
        115                 120                 125             


Asp Phe Pro Cys Gln Thr Glu Ala Gly Leu Ser Val Ile His Thr Arg 
    130                 135                 140                 


Gln Lys Ser Ser Gln Gly Asn Gly Tyr Lys Pro Ser Phe Ser Asp Val 
145                 150                 155                 160 


Ser His Phe Asp Phe His Gln Gln Leu His Ser Gly Glu Lys Ser His 
                165                 170                 175     


Thr Cys Asp Glu Cys Gly Lys Asn Phe Cys Tyr Ile Ser Ala Leu Arg 
            180                 185                 190         


Ile His Gln Arg Val His Met Gly Glu Lys Cys Tyr Lys Cys Asp Val 
        195                 200                 205             


Cys Gly Lys Glu Phe Ser Gln Ser Ser His Leu Gln Thr His Gln Arg 
    210                 215                 220                 


Val His Thr Gly Glu Lys Pro Phe Lys Cys Val Glu Cys Gly Lys Gly 
225                 230                 235                 240 


Phe Ser Arg Arg Ser Ala Leu Asn Val His His Lys Leu His Thr Gly 
                245                 250                 255     


Glu Lys Pro Tyr Asn Cys Glu Glu Cys Gly Lys Ala Phe Ile His Asp 
            260                 265                 270         


Ser Gln Leu Gln Glu His Gln Arg Ile His Thr Gly Glu Lys Pro Phe 
        275                 280                 285             


Lys Cys Asp Ile Cys Gly Lys Ser Phe Cys Gly Arg Ser Arg Leu Asn 
    290                 295                 300                 


Arg His Ser Met Val His Thr Ala Glu Lys Pro Phe Arg Cys Asp Thr 
305                 310                 315                 320 


Cys Asp Lys Ser Phe Arg Gln Arg Ser Ala Leu Asn Ser His Arg Met 
                325                 330                 335     


Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Lys Gly 
            340                 345                 350         


Phe Ile Cys Arg Arg Asp Leu Tyr Thr His His Met Val His Thr Gly 
        355                 360                 365             


Glu Lys Pro Tyr Asn Cys Lys Glu Cys Gly Lys Ser Phe Arg Trp Ala 
    370                 375                 380                 


Ser Cys Leu Leu Lys His Gln Arg Val His Ser Gly Glu Lys Pro Phe 
385                 390                 395                 400 


Lys Cys Glu Glu Cys Gly Lys Gly Phe Tyr Thr Asn Ser Gln Cys Tyr 
                405                 410                 415     


Ser His Gln Arg Ser His Ser Gly Glu Lys Pro Tyr Lys Cys Val Glu 
            420                 425                 430         


Cys Gly Lys Gly Tyr Lys Arg Arg Leu Asp Leu Asp Phe His Gln Arg 
        435                 440                 445             


Val His Thr Gly Glu Lys Leu Tyr Asn Cys Lys Glu Cys Gly Lys Ser 
    450                 455                 460                 


Phe Ser Arg Ala Pro Cys Leu Leu Lys His Glu Arg Leu His Ser Gly 
465                 470                 475                 480 


Glu Lys Pro Phe Gln Cys Glu Glu Cys Gly Lys Arg Phe Thr Gln Asn 
                485                 490                 495     


Ser His Leu His Ser His Gln Arg Val His Thr Gly Glu Lys Pro Tyr 
            500                 505                 510         


Lys Cys Glu Lys Cys Gly Lys Gly Tyr Asn Ser Lys Phe Asn Leu Asp 
        515                 520                 525             


Met His Gln Lys Val His Thr Gly Glu Arg Pro Tyr Asn Cys Lys Glu 
    530                 535                 540                 


Cys Gly Lys Ser Phe Gly Trp Ala Ser Cys Leu Leu Lys His Gln Arg 
545                 550                 555                 560 


Leu His Ser Gly Glu Lys Pro Phe Lys Cys Glu Glu Cys Gly Lys Arg 
                565                 570                 575     


Phe Thr Gln Asn Ser Gln Leu His Ser His Gln Arg Val His Thr Gly 
            580                 585                 590         


Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Gly Phe Ser Trp Ser 
        595                 600                 605             


Ser Thr Arg Leu Thr His Gln Arg Arg His Ser Arg Glu Thr Pro Leu 
    610                 615                 620                 


Lys Cys Glu Gln His Gly Lys Asn Ile Val Gln Asn Ser Phe Ser Lys 
625                 630                 635                 640 


Val Gln Glu Lys Val His Ser Val Glu Lys Pro Tyr Lys Cys Glu Asp 
                645                 650                 655     


Cys Gly Lys Gly Tyr Asn Arg Arg Leu Asn Leu Asp Met His Gln Arg 
            660                 665                 670         


Val His Met Gly Glu Lys Thr Trp Lys Cys Arg Glu Cys Asp Met Cys 
        675                 680                 685             


Phe Ser Gln Ala Ser Ser Leu Arg Leu His Gln Asn Val His Val Gly 
    690                 695                 700                 


Glu Lys Pro 
705         


<210>  41
<211>  939
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Met Pro Ala Val Ser Lys Gly Asp Gly Met Arg Gly Leu Ala Val Phe 
1               5                   10                  15      


Ile Ser Asp Ile Arg Asn Cys Lys Ser Lys Glu Ala Glu Ile Lys Arg 
            20                  25                  30          


Ile Asn Lys Glu Leu Ala Asn Ile Arg Ser Lys Phe Lys Gly Asp Lys 
        35                  40                  45              


Ala Leu Asp Gly Tyr Ser Lys Lys Lys Tyr Val Cys Lys Leu Leu Phe 
    50                  55                  60                  


Ile Phe Leu Leu Gly His Asp Ile Asp Phe Gly His Met Glu Ala Val 
65                  70                  75                  80  


Asn Leu Leu Ser Ser Asn Arg Tyr Thr Glu Lys Gln Ile Gly Tyr Leu 
                85                  90                  95      


Phe Ile Ser Val Leu Val Asn Ser Asn Ser Glu Leu Ile Arg Leu Ile 
            100                 105                 110         


Asn Asn Ala Ile Lys Asn Asp Leu Ala Ser Arg Asn Pro Thr Phe Met 
        115                 120                 125             


Gly Leu Ala Leu His Cys Ile Ala Ser Val Gly Ser Arg Glu Met Ala 
    130                 135                 140                 


Glu Ala Phe Ala Gly Glu Ile Pro Lys Val Leu Val Ala Gly Asp Thr 
145                 150                 155                 160 


Met Asp Ser Val Lys Gln Ser Ala Ala Leu Cys Leu Leu Arg Leu Tyr 
                165                 170                 175     


Arg Thr Ser Pro Asp Leu Val Pro Met Gly Asp Trp Thr Ser Arg Val 
            180                 185                 190         


Val His Leu Leu Asn Asp Gln His Leu Gly Val Val Thr Ala Ala Thr 
        195                 200                 205             


Ser Leu Ile Thr Thr Leu Ala Gln Lys Asn Pro Glu Glu Phe Lys Thr 
    210                 215                 220                 


Ser Val Ser Leu Ala Val Ser Arg Leu Ser Arg Ile Val Thr Ser Ala 
225                 230                 235                 240 


Ser Thr Asp Leu Gln Asp Tyr Thr Tyr Tyr Phe Val Pro Ala Pro Trp 
                245                 250                 255     


Leu Ser Val Lys Leu Leu Arg Leu Leu Gln Cys Tyr Pro Pro Pro Asp 
            260                 265                 270         


Pro Ala Val Arg Gly Arg Leu Thr Glu Cys Leu Glu Thr Ile Leu Asn 
        275                 280                 285             


Lys Ala Gln Glu Pro Pro Lys Ser Lys Lys Val Gln His Ser Asn Ala 
    290                 295                 300                 


Lys Asn Ala Val Leu Phe Glu Ala Ile Ser Leu Ile Ile His His Asp 
305                 310                 315                 320 


Ser Glu Pro Asn Leu Leu Val Arg Ala Cys Asn Gln Leu Gly Gln Phe 
                325                 330                 335     


Leu Gln His Arg Glu Thr Asn Leu Arg Tyr Leu Ala Leu Glu Ser Met 
            340                 345                 350         


Cys Thr Leu Ala Ser Ser Glu Phe Ser His Glu Ala Val Lys Thr His 
        355                 360                 365             


Ile Glu Thr Val Ile Asn Ala Leu Lys Thr Glu Arg Asp Val Ser Val 
    370                 375                 380                 


Arg Gln Arg Ala Val Asp Leu Leu Tyr Ala Met Cys Asp Arg Ser Asn 
385                 390                 395                 400 


Ala Pro Gln Ile Val Ala Glu Met Leu Ser Tyr Leu Glu Thr Ala Asp 
                405                 410                 415     


Tyr Ser Ile Arg Glu Glu Ile Val Leu Lys Val Ala Ile Leu Ala Glu 
            420                 425                 430         


Lys Tyr Ala Val Asp Tyr Thr Trp Tyr Val Asp Thr Ile Leu Asn Leu 
        435                 440                 445             


Ile Arg Ile Ala Gly Asp Tyr Val Ser Glu Glu Val Trp Tyr Arg Val 
    450                 455                 460                 


Ile Gln Ile Val Ile Asn Arg Asp Asp Val Gln Gly Tyr Ala Ala Lys 
465                 470                 475                 480 


Thr Val Phe Glu Ala Leu Gln Ala Pro Ala Cys His Glu Asn Leu Val 
                485                 490                 495     


Lys Val Gly Gly Tyr Ile Leu Gly Glu Phe Gly Asn Leu Ile Ala Gly 
            500                 505                 510         


Asp Pro Arg Ser Ser Pro Leu Ile Gln Phe His Leu Leu His Ser Lys 
        515                 520                 525             


Phe His Leu Cys Ser Val Pro Thr Arg Ala Leu Leu Leu Ser Thr Tyr 
    530                 535                 540                 


Ile Lys Phe Val Asn Leu Phe Pro Glu Val Lys Pro Thr Ile Gln Asp 
545                 550                 555                 560 


Val Leu Arg Ser Asp Ser Gln Leu Arg Asn Ala Asp Val Glu Leu Gln 
                565                 570                 575     


Gln Arg Ala Val Glu Tyr Leu Arg Leu Ser Thr Val Ala Ser Thr Asp 
            580                 585                 590         


Ile Leu Ala Thr Val Leu Glu Glu Met Pro Pro Phe Pro Glu Arg Glu 
        595                 600                 605             


Ser Ser Ile Leu Ala Lys Leu Lys Lys Lys Lys Gly Pro Ser Thr Val 
    610                 615                 620                 


Thr Asp Leu Glu Asp Thr Lys Arg Asp Arg Ser Val Asp Val Asn Gly 
625                 630                 635                 640 


Gly Pro Glu Pro Ala Pro Ala Ser Thr Ser Ala Val Ser Thr Pro Ser 
                645                 650                 655     


Pro Ser Ala Asp Leu Leu Gly Leu Gly Ala Ala Pro Pro Ala Pro Ala 
            660                 665                 670         


Gly Pro Pro Pro Ser Ser Gly Gly Ser Gly Leu Leu Val Asp Val Phe 
        675                 680                 685             


Ser Asp Ser Ala Ser Val Val Ala Pro Leu Ala Pro Gly Ser Glu Asp 
    690                 695                 700                 


Asn Phe Ala Arg Phe Val Cys Lys Asn Asn Gly Val Leu Phe Glu Asn 
705                 710                 715                 720 


Gln Leu Leu Gln Ile Gly Leu Lys Ser Glu Phe Arg Gln Asn Leu Gly 
                725                 730                 735     


Arg Met Phe Ile Phe Tyr Gly Asn Lys Thr Ser Thr Gln Phe Leu Asn 
            740                 745                 750         


Phe Thr Pro Thr Leu Ile Cys Ser Asp Asp Leu Gln Pro Asn Leu Asn 
        755                 760                 765             


Leu Gln Thr Lys Pro Val Asp Pro Thr Val Glu Gly Gly Ala Gln Val 
    770                 775                 780                 


Gln Gln Val Val Asn Ile Glu Cys Val Ser Asp Phe Thr Glu Ala Pro 
785                 790                 795                 800 


Val Leu Asn Ile Gln Phe Arg Tyr Gly Gly Thr Phe Gln Asn Val Ser 
                805                 810                 815     


Val Gln Leu Pro Ile Thr Leu Asn Lys Phe Phe Gln Pro Thr Glu Met 
            820                 825                 830         


Ala Ser Gln Asp Phe Phe Gln Arg Trp Lys Gln Leu Ser Asn Pro Gln 
        835                 840                 845             


Gln Glu Val Gln Asn Ile Phe Lys Ala Lys His Pro Met Asp Thr Glu 
    850                 855                 860                 


Val Thr Lys Ala Lys Ile Ile Gly Phe Gly Ser Ala Leu Leu Glu Glu 
865                 870                 875                 880 


Val Asp Pro Asn Pro Ala Asn Phe Val Gly Ala Gly Ile Ile His Thr 
                885                 890                 895     


Lys Thr Thr Gln Ile Gly Cys Leu Leu Arg Leu Glu Pro Asn Leu Gln 
            900                 905                 910         


Ala Gln Met Tyr Arg Leu Thr Leu Arg Thr Ser Lys Glu Ala Val Ser 
        915                 920                 925             


Gln Arg Leu Cys Glu Leu Leu Ser Ala Gln Phe 
    930                 935                 


<210>  42
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Met Glu Ala Leu Ile Pro Val Ile Asn Lys Leu Gln Asp Val Phe Asn 
1               5                   10                  15      


Thr Val Gly Ala Asp Ile Ile Gln Leu Pro Gln Ile Val Val Val Gly 
            20                  25                  30          


Thr Gln Ser Ser Gly Lys Ser Ser Val Leu Glu Ser Leu Val Gly Arg 
        35                  40                  45              


Asp Leu Leu Pro Arg Gly Thr Gly Ile Val Thr Arg Arg Pro Leu Ile 
    50                  55                  60                  


Leu Gln Leu Val His Val Ser Gln Glu Asp Lys Arg Lys Thr Thr Gly 
65                  70                  75                  80  


Glu Glu Asn Gly Val Glu Ala Glu Glu Trp Gly Lys Phe Leu His Thr 
                85                  90                  95      


Lys Asn Lys Leu Tyr Thr Asp Phe Asp Glu Ile Arg Gln Glu Ile Glu 
            100                 105                 110         


Asn Glu Thr Glu Arg Ile Ser Gly Asn Asn Lys Gly Val Ser Pro Glu 
        115                 120                 125             


Pro Ile His Leu Lys Ile Phe Ser Pro Asn Val Val Asn Leu Thr Leu 
    130                 135                 140                 


Val Asp Leu Pro Gly Met Thr Lys Val Pro Val Gly Asp Gln Pro Lys 
145                 150                 155                 160 


Asp Ile Glu Leu Gln Ile Arg Glu Leu Ile Leu Arg Phe Ile Ser Asn 
                165                 170                 175     


Pro Asn Ser Ile Ile Leu Ala Val Thr Ala Ala Asn Thr Asp Met Ala 
            180                 185                 190         


Thr Ser Glu Ala Leu Lys Ile Ser Arg Glu Val Asp Pro Asp Gly Arg 
        195                 200                 205             


Arg Thr Leu Ala Val Ile Thr Lys Leu Asp Leu Met Asp Ala Gly Thr 
    210                 215                 220                 


Asp Ala Met Asp Val Leu Met Gly Arg Val Ile Pro Val Lys Leu Gly 
225                 230                 235                 240 


Ile Ile Gly Val Val Asn Arg Ser Gln Leu Asp Ile Asn Asn Lys Lys 
                245                 250                 255     


Ser Val Thr Asp Ser Ile Arg Asp Glu Tyr Ala Phe Leu Gln Lys Lys 
            260                 265                 270         


Tyr Pro Ser Leu Ala Asn Arg Asn Gly Thr Lys Tyr Leu Ala Arg Thr 
        275                 280                 285             


Leu Asn Arg Leu Leu Met His His Ile Arg Asp Cys Leu Pro Glu Leu 
    290                 295                 300                 


Lys Thr Arg Ile Asn Val Leu Ala Ala Gln Tyr Gln Ser Leu Leu Asn 
305                 310                 315                 320 


Ser Tyr Gly Glu Pro Val Asp Asp Lys Ser Ala Thr Leu Leu Gln Leu 
                325                 330                 335     


Ile Thr Lys Phe Ala Thr Glu Tyr Cys Asn Thr Ile Glu Gly Thr Ala 
            340                 345                 350         


Lys Tyr Ile Glu Thr Ser Glu Leu Cys Gly Gly Ala Arg Ile Cys Tyr 
        355                 360                 365             


Ile Phe His Glu Thr Phe Gly Arg Thr Leu Glu Ser Val Asp Pro Leu 
    370                 375                 380                 


Gly Gly Leu Asn Thr Ile Asp Ile Leu Thr Ala Ile Arg Asn Ala Thr 
385                 390                 395                 400 


Gly Pro Arg Pro Ala Leu Phe Val Pro Glu Val Ser Phe Glu Leu Leu 
                405                 410                 415     


Val Lys Arg Gln Ile Lys Arg Leu Glu Glu Pro Ser Leu Arg Cys Val 
            420                 425                 430         


Glu Leu Val His Glu Glu Met Gln Arg Ile Ile Gln His Cys Ser Asn 
        435                 440                 445             


Tyr Ser Thr Gln Glu Leu Leu Arg Phe Pro Lys Leu His Asp Ala Ile 
    450                 455                 460                 


Val Glu Val Val Thr Cys Leu Leu Arg Lys Arg Leu Pro Val Thr Asn 
465                 470                 475                 480 


Glu Met Val His Asn Leu Val Ala Ile Glu Leu Ala Tyr Ile Asn Thr 
                485                 490                 495     


Lys His Pro Asp Phe Ala Asp Ala Cys Gly Leu Met Asn Asn Asn Ile 
            500                 505                 510         


Glu Glu Gln Arg Arg Asn Arg Leu Ala Arg Glu Leu Pro Ser Ala Val 
        515                 520                 525             


Ser Arg Asp Lys Ser Ser Lys Val Pro Ser Ala Leu Ala Pro Ala Ser 
    530                 535                 540                 


Gln Glu Pro Ser Pro Ala Ala Ser Ala Glu Ala Asp Gly Lys Leu Ile 
545                 550                 555                 560 


Gln Asp Ser Arg Arg Glu Thr Lys Asn Val Ala Ser Gly Gly Gly Gly 
                565                 570                 575     


Val Gly Asp Gly Val Gln Glu Pro Thr Thr Gly Asn Trp Arg Gly Met 
            580                 585                 590         


Leu Lys Thr Ser Lys Ala Glu Glu Leu Leu Ala Glu Glu Lys Ser Lys 
        595                 600                 605             


Pro Ile Pro Ile Met Pro Ala Ser Pro Gln Lys Gly His Ala Val Asn 
    610                 615                 620                 


Leu Leu Asp Val Pro Val Pro Val Ala Arg Lys Leu Ser Ala Arg Glu 
625                 630                 635                 640 


Gln Arg Asp Cys Glu Val Ile Glu Arg Leu Ile Lys Ser Tyr Phe Leu 
                645                 650                 655     


Ile Val Arg Lys Asn Ile Gln Asp Ser Val Pro Lys Ala Val Met His 
            660                 665                 670         


Phe Leu Val Asn His Val Lys Asp Thr Leu Gln Ser Glu Leu Val Gly 
        675                 680                 685             


Gln Leu Tyr Lys Ser Ser Leu Leu Asp Asp Leu Leu Thr Glu Ser Glu 
    690                 695                 700                 


Asp Met Ala Gln Arg Arg Lys Glu Ala Ala Asp Met Leu Lys Ala Leu 
705                 710                 715                 720 


Gln Gly Ala Ser Gln Ile Ile Ala Glu Ile Arg Glu Thr His Leu Trp 
                725                 730                 735     


<210>  43
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43

Met Gly Arg Cys Cys Phe Tyr Thr Ala Gly Thr Leu Ser Leu Leu Leu 
1               5                   10                  15      


Leu Val Thr Ser Val Thr Leu Leu Val Ala Arg Val Phe Gln Lys Ala 
            20                  25                  30          


Val Asp Gln Ser Ile Glu Lys Lys Ile Val Leu Arg Asn Gly Thr Glu 
        35                  40                  45              


Ala Phe Asp Ser Trp Glu Lys Pro Pro Leu Pro Val Tyr Thr Gln Phe 
    50                  55                  60                  


Tyr Phe Phe Asn Val Thr Asn Pro Glu Glu Ile Leu Arg Gly Glu Thr 
65                  70                  75                  80  


Pro Arg Val Glu Glu Val Gly Pro Tyr Thr Tyr Arg Glu Leu Arg Asn 
                85                  90                  95      


Lys Ala Asn Ile Gln Phe Gly Asp Asn Gly Thr Thr Ile Ser Ala Val 
            100                 105                 110         


Ser Asn Lys Ala Tyr Val Phe Glu Arg Asp Gln Ser Val Gly Asp Pro 
        115                 120                 125             


Lys Ile Asp Leu Ile Arg Thr Leu Asn Ile Pro Val Leu Thr Val Ile 
    130                 135                 140                 


Glu Trp Ser Gln Val His Phe Leu Arg Glu Ile Ile Glu Ala Met Leu 
145                 150                 155                 160 


Lys Ala Tyr Gln Gln Lys Leu Phe Val Thr His Thr Val Asp Glu Leu 
                165                 170                 175     


Leu Trp Gly Tyr Lys Asp Glu Ile Leu Ser Leu Ile His Val Phe Arg 
            180                 185                 190         


Pro Asp Ile Ser Pro Tyr Phe Gly Leu Phe Tyr Glu Lys Asn Gly Thr 
        195                 200                 205             


Asn Asp Gly Asp Tyr Val Phe Leu Thr Gly Glu Asp Ser Tyr Leu Asn 
    210                 215                 220                 


Phe Thr Lys Ile Val Glu Trp Asn Gly Lys Thr Ser Leu Asp Trp Trp 
225                 230                 235                 240 


Ile Thr Asp Lys Cys Asn Met Ile Asn Gly Thr Asp Gly Asp Ser Phe 
                245                 250                 255     


His Pro Leu Ile Thr Lys Asp Glu Val Leu Tyr Val Phe Pro Ser Asp 
            260                 265                 270         


Phe Cys Arg Ser Val Tyr Ile Thr Phe Ser Asp Tyr Glu Ser Val Gln 
        275                 280                 285             


Gly Leu Pro Ala Phe Arg Tyr Lys Val Pro Ala Glu Ile Leu Ala Asn 
    290                 295                 300                 


Thr Ser Asp Asn Ala Gly Phe Cys Ile Pro Glu Gly Asn Cys Leu Gly 
305                 310                 315                 320 


Ser Gly Val Leu Asn Val Ser Ile Cys Lys Asn Gly Ala Pro Ile Ile 
                325                 330                 335     


Met Ser Phe Pro His Phe Tyr Gln Ala Asp Glu Arg Phe Val Ser Ala 
            340                 345                 350         


Ile Glu Gly Met His Pro Asn Gln Glu Asp His Glu Thr Phe Val Asp 
        355                 360                 365             


Ile Asn Pro Leu Thr Gly Ile Ile Leu Lys Ala Ala Lys Arg Phe Gln 
    370                 375                 380                 


Ile Asn Ile Tyr Val Lys Lys Leu Asp Asp Phe Val Glu Thr Gly Asp 
385                 390                 395                 400 


Ile Arg Thr Met Val Phe Pro Val Met Tyr Leu Asn Glu Ser Val His 
                405                 410                 415     


Ile Asp Lys Glu Thr Ala Ser Arg Leu Lys Ser Met Ile Asn Thr Thr 
            420                 425                 430         


Leu Ile Ile Thr Asn Ile Pro Tyr Ile Ile Met Ala Leu Gly Val Phe 
        435                 440                 445             


Phe Gly Leu Val Phe Thr Trp Leu Ala Cys Lys Gly Gln Gly Ser Met 
    450                 455                 460                 


Asp Glu Gly Thr Ala Asp Glu Arg Ala Pro Leu Ile Arg Thr 
465                 470                 475             


<210>  44
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Met Glu Cys Leu Tyr Tyr Phe Leu Gly Phe Leu Leu Leu Ala Ala Arg 
1               5                   10                  15      


Leu Pro Leu Asp Ala Ala Lys Arg Phe His Asp Val Leu Gly Asn Glu 
            20                  25                  30          


Arg Pro Ser Ala Tyr Met Arg Glu His Asn Gln Leu Asn Gly Trp Ser 
        35                  40                  45              


Ser Asp Glu Asn Asp Trp Asn Glu Lys Leu Tyr Pro Val Trp Lys Arg 
    50                  55                  60                  


Gly Asp Met Arg Trp Lys Asn Ser Trp Lys Gly Gly Arg Val Gln Ala 
65                  70                  75                  80  


Val Leu Thr Ser Asp Ser Pro Ala Leu Val Gly Ser Asn Ile Thr Phe 
                85                  90                  95      


Ala Val Asn Leu Ile Phe Pro Arg Cys Gln Lys Glu Asp Ala Asn Gly 
            100                 105                 110         


Asn Ile Val Tyr Glu Lys Asn Cys Arg Asn Glu Ala Gly Leu Ser Ala 
        115                 120                 125             


Asp Pro Tyr Val Tyr Asn Trp Thr Ala Trp Ser Glu Asp Ser Asp Gly 
    130                 135                 140                 


Glu Asn Gly Thr Gly Gln Ser His His Asn Val Phe Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Phe Pro His His Pro Gly Trp Arg Arg Trp Asn Phe Ile Tyr Val 
                165                 170                 175     


Phe His Thr Leu Gly Gln Tyr Phe Gln Lys Leu Gly Arg Cys Ser Val 
            180                 185                 190         


Arg Val Ser Val Asn Thr Ala Asn Val Thr Leu Gly Pro Gln Leu Met 
        195                 200                 205             


Glu Val Thr Val Tyr Arg Arg His Gly Arg Ala Tyr Val Pro Ile Ala 
    210                 215                 220                 


Gln Val Lys Asp Val Tyr Val Val Thr Asp Gln Ile Pro Val Phe Val 
225                 230                 235                 240 


Thr Met Phe Gln Lys Asn Asp Arg Asn Ser Ser Asp Glu Thr Phe Leu 
                245                 250                 255     


Lys Asp Leu Pro Ile Met Phe Asp Val Leu Ile His Asp Pro Ser His 
            260                 265                 270         


Phe Leu Asn Tyr Ser Thr Ile Asn Tyr Lys Trp Ser Phe Gly Asp Asn 
        275                 280                 285             


Thr Gly Leu Phe Val Ser Thr Asn His Thr Val Asn His Thr Tyr Val 
    290                 295                 300                 


Leu Asn Gly Thr Phe Ser Leu Asn Leu Thr Val Lys Ala Ala Ala Pro 
305                 310                 315                 320 


Gly Pro Cys Pro Pro Pro Pro Pro Pro Pro Arg Pro Ser Lys Pro Thr 
                325                 330                 335     


Pro Ser Leu Ala Thr Thr Leu Lys Ser Tyr Asp Ser Asn Thr Pro Gly 
            340                 345                 350         


Pro Ala Gly Asp Asn Pro Leu Glu Leu Ser Arg Ile Pro Asp Glu Asn 
        355                 360                 365             


Cys Gln Ile Asn Arg Tyr Gly His Phe Gln Ala Thr Ile Thr Ile Val 
    370                 375                 380                 


Glu Gly Ile Leu Glu Val Asn Ile Ile Gln Met Thr Asp Val Leu Met 
385                 390                 395                 400 


Pro Val Pro Trp Pro Glu Ser Ser Leu Ile Asp Phe Val Val Thr Cys 
                405                 410                 415     


Gln Gly Ser Ile Pro Thr Glu Val Cys Thr Ile Ile Ser Asp Pro Thr 
            420                 425                 430         


Cys Glu Ile Thr Gln Asn Thr Val Cys Ser Pro Val Asp Val Asp Glu 
        435                 440                 445             


Met Cys Leu Leu Thr Val Arg Arg Thr Phe Asn Gly Ser Gly Thr Tyr 
    450                 455                 460                 


Cys Val Asn Leu Thr Leu Gly Asp Asp Thr Ser Leu Ala Leu Thr Ser 
465                 470                 475                 480 


Thr Leu Ile Ser Val Pro Asp Arg Asp Pro Ala Ser Pro Leu Arg Met 
                485                 490                 495     


Ala Asn Ser Ala Leu Ile Ser Val Gly Cys Leu Ala Ile Phe Val Thr 
            500                 505                 510         


Val Ile Ser Leu Leu Val Tyr Lys Lys His Lys Glu Tyr Asn Pro Ile 
        515                 520                 525             


Glu Asn Ser Pro Gly Asn Val Val Arg Ser Lys Gly Leu Ser Val Phe 
    530                 535                 540                 


Leu Asn Arg Ala Lys Ala Val Phe Phe Pro Gly Asn Gln Glu Lys Asp 
545                 550                 555                 560 


Pro Leu Leu Lys Asn Gln Glu Phe Lys Gly Val Ser 
                565                 570         


<210>  45
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45

Met Pro Thr Thr Gln Gln Ser Pro Gln Asp Glu Gln Glu Lys Leu Leu 
1               5                   10                  15      


Asp Glu Ala Ile Gln Ala Val Lys Val Gln Ser Phe Gln Met Lys Arg 
            20                  25                  30          


Cys Leu Asp Lys Asn Lys Leu Met Asp Ala Leu Lys His Ala Ser Asn 
        35                  40                  45              


Met Leu Gly Glu Leu Arg Thr Ser Met Leu Ser Pro Lys Ser Tyr Tyr 
    50                  55                  60                  


Glu Leu Tyr Met Ala Ile Ser Asp Glu Leu His Tyr Leu Glu Val Tyr 
65                  70                  75                  80  


Leu Thr Asp Glu Phe Ala Lys Gly Arg Lys Val Ala Asp Leu Tyr Glu 
                85                  90                  95      


Leu Val Gln Tyr Ala Gly Asn Ile Ile Pro Arg Leu Tyr Leu Leu Ile 
            100                 105                 110         


Thr Val Gly Val Val Tyr Val Lys Ser Phe Pro Gln Ser Arg Lys Asp 
        115                 120                 125             


Ile Leu Lys Asp Leu Val Glu Met Cys Arg Gly Val Gln His Pro Leu 
    130                 135                 140                 


Arg Gly Leu Phe Leu Arg Asn Tyr Leu Leu Gln Cys Thr Arg Asn Ile 
145                 150                 155                 160 


Leu Pro Asp Glu Gly Glu Pro Thr Asp Glu Glu Thr Thr Gly Asp Ile 
                165                 170                 175     


Ser Asp Ser Met Asp Phe Val Leu Leu Asn Phe Ala Glu Met Asn Lys 
            180                 185                 190         


Leu Trp Val Arg Met Gln His Gln Gly His Ser Arg Asp Arg Glu Lys 
        195                 200                 205             


Arg Glu Arg Glu Arg Gln Glu Leu Arg Ile Leu Val Gly Thr Asn Leu 
    210                 215                 220                 


Val Arg Leu Ser Gln Leu Glu Gly Val Asn Val Glu Arg Tyr Lys Gln 
225                 230                 235                 240 


Ile Val Leu Thr Gly Ile Leu Glu Gln Val Val Asn Cys Arg Asp Ala 
                245                 250                 255     


Leu Ala Gln Glu Tyr Leu Met Glu Cys Ile Ile Gln Val Phe Pro Asp 
            260                 265                 270         


Glu Phe His Leu Gln Thr Leu Asn Pro Phe Leu Arg Ala Cys Ala Glu 
        275                 280                 285             


Leu His Gln Asn Val Asn Val Lys Asn Ile Ile Ile Ala Leu Ile Asp 
    290                 295                 300                 


Arg Leu Ala Leu Phe Ala His Arg Glu Asp Gly Pro Gly Ile Pro Ala 
305                 310                 315                 320 


Asp Ile Lys Leu Phe Asp Ile Phe Ser Gln Gln Val Ala Thr Val Ile 
                325                 330                 335     


Gln Ser Arg Gln Asp Met Pro Ser Glu Asp Val Val Ser Leu Gln Val 
            340                 345                 350         


Ser Leu Ile Asn Leu Ala Met Lys Cys Tyr Pro Asp Arg Val Asp Tyr 
        355                 360                 365             


Val Asp Lys Val Leu Glu Thr Thr Val Glu Ile Phe Asn Lys Leu Asn 
    370                 375                 380                 


Leu Glu His Ile Ala Thr Ser Ser Ala Val Ser Lys Glu Leu Thr Arg 
385                 390                 395                 400 


Leu Leu Lys Ile Pro Val Asp Thr Tyr Asn Asn Ile Leu Thr Val Leu 
                405                 410                 415     


Lys Leu Lys His Phe His Pro Leu Phe Glu Tyr Phe Asp Tyr Glu Ser 
            420                 425                 430         


Arg Lys Ser Met Ser Cys Tyr Val Leu Ser Asn Val Leu Asp Tyr Asn 
        435                 440                 445             


Thr Glu Ile Val Ser Gln Asp Gln Val Asp Ser Ile Met Asn Leu Val 
    450                 455                 460                 


Ser Thr Leu Ile Gln Asp Gln Pro Asp Gln Pro Val Glu Asp Pro Asp 
465                 470                 475                 480 


Pro Glu Asp Phe Ala Asp Glu Gln Ser Leu Val Gly Arg Phe Ile His 
                485                 490                 495     


Leu Leu Arg Ser Glu Asp Pro Asp Gln Gln Tyr Leu Ile Leu Asn Thr 
            500                 505                 510         


Ala Arg Lys His Phe Gly Ala Gly Gly Asn Gln Arg Ile Arg Phe Thr 
        515                 520                 525             


Leu Pro Pro Leu Val Phe Ala Ala Tyr Gln Leu Ala Phe Arg Tyr Lys 
    530                 535                 540                 


Glu Asn Ser Lys Val Asp Asp Lys Trp Glu Lys Lys Cys Gln Lys Ile 
545                 550                 555                 560 


Phe Ser Phe Ala His Gln Thr Ile Ser Ala Leu Ile Lys Ala Glu Leu 
                565                 570                 575     


Ala Glu Leu Pro Leu Arg Leu Phe Leu Gln Gly Ala Leu Ala Ala Gly 
            580                 585                 590         


Glu Ile Gly Phe Glu Asn His Glu Thr Val Ala Tyr Glu Phe Met Ser 
        595                 600                 605             


Gln Ala Phe Ser Leu Tyr Glu Asp Glu Ile Ser Asp Ser Lys Ala Gln 
    610                 615                 620                 


Leu Ala Ala Ile Thr Leu Ile Ile Gly Thr Phe Glu Arg Met Lys Cys 
625                 630                 635                 640 


Phe Ser Glu Glu Asn His Glu Pro Leu Arg Thr Gln Cys Ala Leu Ala 
                645                 650                 655     


Ala Ser Lys Leu Leu Lys Lys Pro Asp Gln Gly Arg Ala Val Ser Thr 
            660                 665                 670         


Cys Ala His Leu Phe Trp Ser Gly Arg Asn Thr Asp Lys Asn Gly Glu 
        675                 680                 685             


Glu Leu His Gly Gly Lys Arg Val Met Glu Cys Leu Lys Lys Ala Leu 
    690                 695                 700                 


Lys Ile Ala Asn Gln Cys Met Asp Pro Ser Leu Gln Val Gln Leu Phe 
705                 710                 715                 720 


Ile Glu Ile Leu Asn Arg Tyr Ile Tyr Phe Tyr Glu Lys Glu Asn Asp 
                725                 730                 735     


Ala Val Thr Ile Gln Val Leu Asn Gln Leu Ile Gln Lys Ile Arg Glu 
            740                 745                 750         


Asp Leu Pro Asn Leu Glu Ser Ser Glu Glu Thr Glu Gln Ile Asn Lys 
        755                 760                 765             


His Phe His Asn Thr Leu Glu His Leu Arg Leu Arg Arg Glu Ser Pro 
    770                 775                 780                 


Glu Ser Glu Gly Pro Ile Tyr Glu Gly Leu Ile Leu 
785                 790                 795     


<210>  46
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Met Arg Leu Arg Val Arg Leu Leu Lys Arg Thr Trp Pro Leu Glu Val 
1               5                   10                  15      


Pro Glu Thr Glu Pro Thr Leu Gly His Leu Arg Ser His Leu Arg Gln 
            20                  25                  30          


Ser Leu Leu Cys Thr Trp Gly Tyr Ser Ser Asn Thr Arg Phe Thr Ile 
        35                  40                  45              


Thr Leu Asn Tyr Lys Asp Pro Leu Thr Gly Asp Glu Glu Thr Leu Ala 
    50                  55                  60                  


Ser Tyr Gly Ile Val Ser Gly Asp Leu Ile Cys Leu Ile Leu Gln Asp 
65                  70                  75                  80  


Asp Ile Pro Ala Pro Asn Ile Pro Ser Ser Thr Asp Ser Glu His Ser 
                85                  90                  95      


Ser Leu Gln Asn Asn Glu Gln Pro Ser Leu Ala Thr Ser Ser Asn Gln 
            100                 105                 110         


Thr Ser Met Gln Asp Glu Gln Pro Ser Asp Ser Phe Gln Gly Gln Ala 
        115                 120                 125             


Ala Gln Ser Gly Val Trp Asn Asp Asp Ser Met Leu Gly Pro Ser Gln 
    130                 135                 140                 


Asn Phe Glu Ala Glu Ser Ile Gln Asp Asn Ala His Met Ala Glu Gly 
145                 150                 155                 160 


Thr Gly Phe Tyr Pro Ser Glu Pro Met Leu Cys Ser Glu Ser Val Glu 
                165                 170                 175     


Gly Gln Val Pro His Ser Leu Glu Thr Leu Tyr Gln Ser Ala Asp Cys 
            180                 185                 190         


Ser Asp Ala Asn Asp Ala Leu Ile Val Leu Ile His Leu Leu Met Leu 
        195                 200                 205             


Glu Ser Gly Tyr Ile Pro Gln Gly Thr Glu Ala Lys Ala Leu Ser Met 
    210                 215                 220                 


Pro Glu Lys Trp Lys Leu Ser Gly Val Tyr Lys Leu Gln Tyr Met His 
225                 230                 235                 240 


Pro Leu Cys Glu Gly Ser Ser Ala Thr Leu Thr Cys Val Pro Leu Gly 
                245                 250                 255     


Asn Leu Ile Val Val Asn Ala Thr Leu Lys Ile Asn Asn Glu Ile Arg 
            260                 265                 270         


Ser Val Lys Arg Leu Gln Leu Leu Pro Glu Ser Phe Ile Cys Lys Glu 
        275                 280                 285             


Lys Leu Gly Glu Asn Val Ala Asn Ile Tyr Lys Asp Leu Gln Lys Leu 
    290                 295                 300                 


Ser Arg Leu Phe Lys Asp Gln Leu Val Tyr Pro Leu Leu Ala Phe Thr 
305                 310                 315                 320 


Arg Gln Ala Leu Asn Leu Pro Asp Val Phe Gly Leu Val Val Leu Pro 
                325                 330                 335     


Leu Glu Leu Lys Leu Arg Ile Phe Arg Leu Leu Asp Val Arg Ser Val 
            340                 345                 350         


Leu Ser Leu Ser Ala Val Cys Arg Asp Leu Phe Thr Ala Ser Asn Asp 
        355                 360                 365             


Pro Leu Leu Trp Arg Phe Leu Tyr Leu Arg Asp Phe Arg Asp Asn Thr 
    370                 375                 380                 


Val Arg Val Gln Asp Thr Asp Trp Lys Glu Leu Tyr Arg Lys Arg His 
385                 390                 395                 400 


Ile Gln Arg Lys Glu Ser Pro Lys Gly Arg Phe Val Met Leu Leu Pro 
                405                 410                 415     


Ser Ser Thr His Thr Ile Pro Phe Tyr Pro Asn Pro Leu His Pro Arg 
            420                 425                 430         


Pro Phe Pro Ser Ser Arg Leu Pro Pro Gly Ile Ile Gly Gly Glu Tyr 
        435                 440                 445             


Asp Gln Arg Pro Thr Leu Pro Tyr Val Gly Asp Pro Ile Ser Ser Leu 
    450                 455                 460                 


Ile Pro Gly Pro Gly Glu Thr Pro Ser Gln Phe Pro Pro Leu Arg Pro 
465                 470                 475                 480 


Arg Phe Asp Pro Val Gly Pro Leu Pro Gly Pro Asn Pro Ile Leu Pro 
                485                 490                 495     


Gly Arg Gly Gly Pro Asn Asp Arg Phe Pro Phe Arg Pro Ser Arg Gly 
            500                 505                 510         


Arg Pro Thr Asp Gly Arg Leu Ser Phe Met 
        515                 520         


<210>  47
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47

Met Ala Ser Lys Arg Ala Leu Val Ile Leu Ala Lys Gly Ala Glu Glu 
1               5                   10                  15      


Met Glu Thr Val Ile Pro Val Asp Val Met Arg Arg Ala Gly Ile Lys 
            20                  25                  30          


Val Thr Val Ala Gly Leu Ala Gly Lys Asp Pro Val Gln Cys Ser Arg 
        35                  40                  45              


Asp Val Val Ile Cys Pro Asp Ala Ser Leu Glu Asp Ala Lys Lys Glu 
    50                  55                  60                  


Gly Pro Tyr Asp Val Val Val Leu Pro Gly Gly Asn Leu Gly Ala Gln 
65                  70                  75                  80  


Asn Leu Ser Glu Ser Ala Ala Val Lys Glu Ile Leu Lys Glu Gln Glu 
                85                  90                  95      


Asn Arg Lys Gly Leu Ile Ala Ala Ile Cys Ala Gly Pro Thr Ala Leu 
            100                 105                 110         


Leu Ala His Glu Ile Gly Phe Gly Ser Lys Val Thr Thr His Pro Leu 
        115                 120                 125             


Ala Lys Asp Lys Met Met Asn Gly Gly His Tyr Thr Tyr Ser Glu Asn 
    130                 135                 140                 


Arg Val Glu Lys Asp Gly Leu Ile Leu Thr Ser Arg Gly Pro Gly Thr 
145                 150                 155                 160 


Ser Phe Glu Phe Ala Leu Ala Ile Val Glu Ala Leu Asn Gly Lys Glu 
                165                 170                 175     


Val Ala Ala Gln Val Lys Ala Pro Leu Val Leu Lys Asp 
            180                 185                 


<210>  48
<211>  1132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Met Glu Leu Phe Gln Ala Lys Asp His Tyr Ile Leu Gln Gln Gly Glu 
1               5                   10                  15      


Arg Ala Leu Trp Cys Ser Arg Arg Asp Gly Gly Leu Gln Leu Arg Pro 
            20                  25                  30          


Ala Thr Asp Leu Leu Leu Ala Trp Asn Pro Ile Cys Leu Gly Leu Val 
        35                  40                  45              


Glu Gly Val Ile Gly Lys Ile Gln Leu His Ser Asp Leu Pro Trp Trp 
    50                  55                  60                  


Leu Ile Leu Ile Arg Gln Lys Ala Leu Val Gly Lys Leu Pro Gly Asp 
65                  70                  75                  80  


His Glu Val Cys Lys Val Thr Lys Ile Ala Val Leu Ser Leu Ser Glu 
                85                  90                  95      


Met Glu Pro Gln Asp Leu Glu Leu Glu Leu Cys Lys Lys His His Phe 
            100                 105                 110         


Gly Ile Asn Lys Pro Glu Lys Ile Ile Pro Ser Pro Asp Asp Ser Lys 
        115                 120                 125             


Phe Leu Leu Lys Thr Phe Thr His Ile Lys Ser Asn Val Ser Ala Pro 
    130                 135                 140                 


Asn Lys Lys Lys Val Lys Glu Ser Lys Glu Lys Glu Lys Leu Glu Arg 
145                 150                 155                 160 


Arg Leu Leu Glu Glu Leu Leu Lys Met Phe Met Asp Ser Glu Ser Phe 
                165                 170                 175     


Tyr Tyr Ser Leu Thr Tyr Asp Leu Thr Asn Ser Val Gln Arg Gln Ser 
            180                 185                 190         


Thr Gly Glu Arg Asp Gly Arg Pro Leu Trp Gln Lys Val Asp Asp Arg 
        195                 200                 205             


Phe Phe Trp Asn Lys Tyr Met Ile Gln Asp Leu Thr Glu Ile Gly Thr 
    210                 215                 220                 


Pro Asp Val Asp Phe Trp Ile Ile Pro Met Ile Gln Gly Phe Val Gln 
225                 230                 235                 240 


Ile Glu Glu Leu Val Val Asn Tyr Thr Glu Ser Ser Asp Asp Glu Lys 
                245                 250                 255     


Ser Ser Pro Glu Thr Pro Pro Gln Glu Ser Thr Cys Val Asp Asp Ile 
            260                 265                 270         


His Pro Arg Phe Leu Val Ala Leu Ile Ser Arg Arg Ser Arg His Arg 
        275                 280                 285             


Ala Gly Met Arg Tyr Lys Arg Arg Gly Val Asp Lys Asn Gly Asn Val 
    290                 295                 300                 


Ala Asn Tyr Val Glu Thr Glu Gln Leu Ile His Val His Asn His Thr 
305                 310                 315                 320 


Leu Ser Phe Val Gln Thr Arg Gly Ser Val Pro Val Phe Trp Ser Gln 
                325                 330                 335     


Val Gly Tyr Arg Tyr Asn Pro Arg Pro Arg Leu Asp Arg Ser Glu Lys 
            340                 345                 350         


Glu Thr Val Ala Tyr Phe Cys Ala His Phe Glu Glu Gln Leu Asn Ile 
        355                 360                 365             


Tyr Lys Lys Gln Val Ile Ile Asn Leu Val Asp Gln Ala Gly Arg Glu 
    370                 375                 380                 


Lys Ile Ile Gly Asp Ala Tyr Leu Lys Gln Val Leu Leu Phe Asn Asn 
385                 390                 395                 400 


Ser His Leu Thr Tyr Val Ser Phe Asp Phe His Glu His Cys Arg Gly 
                405                 410                 415     


Met Lys Phe Glu Asn Val Gln Thr Leu Thr Asp Ala Ile Tyr Asp Ile 
            420                 425                 430         


Ile Leu Asp Met Lys Trp Cys Trp Val Asp Glu Ala Gly Val Ile Cys 
        435                 440                 445             


Lys Gln Glu Gly Ile Phe Arg Val Asn Cys Met Asp Cys Leu Asp Arg 
    450                 455                 460                 


Thr Asn Val Val Gln Ala Ala Ile Ala Arg Val Val Met Glu Gln Gln 
465                 470                 475                 480 


Leu Lys Lys Leu Gly Val Met Pro Pro Glu Gln Pro Leu Pro Val Lys 
                485                 490                 495     


Cys Asn Arg Ile Tyr Gln Ile Met Trp Ala Asn Asn Gly Asp Ser Ile 
            500                 505                 510         


Ser Arg Gln Tyr Ala Gly Thr Ala Ala Leu Lys Gly Asp Phe Thr Arg 
        515                 520                 525             


Thr Gly Glu Arg Lys Leu Ala Gly Val Met Lys Asp Gly Val Asn Ser 
    530                 535                 540                 


Ala Asn Arg Tyr Tyr Leu Asn Arg Phe Lys Asp Ala Tyr Arg Gln Ala 
545                 550                 555                 560 


Val Ile Asp Leu Met Gln Gly Ile Pro Val Thr Glu Asp Leu Tyr Ser 
                565                 570                 575     


Ile Phe Thr Lys Glu Lys Glu His Glu Ala Leu His Lys Glu Asn Gln 
            580                 585                 590         


Arg Ser His Gln Glu Leu Ile Ser Gln Leu Leu Gln Ser Tyr Met Lys 
        595                 600                 605             


Leu Leu Leu Pro Asp Asp Glu Lys Phe His Gly Gly Trp Ala Leu Ile 
    610                 615                 620                 


Asp Cys Asp Pro Ser Leu Ile Asp Ala Thr His Arg Asp Val Asp Val 
625                 630                 635                 640 


Leu Leu Leu Leu Ser Asn Ser Ala Tyr Tyr Val Ala Tyr Tyr Asp Asp 
                645                 650                 655     


Glu Val Asp Lys Val Asn Gln Tyr Gln Arg Leu Ser Leu Glu Asn Leu 
            660                 665                 670         


Glu Lys Ile Glu Ile Gly Pro Glu Pro Thr Leu Phe Gly Lys Pro Lys 
        675                 680                 685             


Phe Ser Cys Met Arg Leu His Tyr Arg Tyr Lys Glu Ala Ser Gly Tyr 
    690                 695                 700                 


Phe His Thr Leu Arg Ala Val Met Arg Asn Pro Glu Glu Asp Gly Lys 
705                 710                 715                 720 


Asp Thr Leu Gln Cys Ile Ala Glu Met Leu Gln Ile Thr Lys Gln Ala 
                725                 730                 735     


Met Gly Ser Asp Leu Pro Ile Ile Glu Lys Lys Leu Glu Arg Lys Ser 
            740                 745                 750         


Ser Lys Pro His Glu Asp Ile Ile Gly Ile Arg Ser Gln Asn Gln Gly 
        755                 760                 765             


Ser Leu Ala Gln Gly Lys Asn Phe Leu Met Ser Lys Phe Ser Ser Leu 
    770                 775                 780                 


Asn Gln Lys Val Lys Gln Thr Lys Ser Asn Val Asn Ile Gly Asn Leu 
785                 790                 795                 800 


Arg Lys Leu Gly Asn Phe Thr Lys Pro Glu Met Lys Val Asn Phe Leu 
                805                 810                 815     


Lys Pro Asn Leu Lys Val Asn Leu Trp Lys Ser Asp Ser Ser Leu Glu 
            820                 825                 830         


Thr Met Glu Asn Thr Gly Val Met Asp Lys Val Gln Ala Glu Ser Asp 
        835                 840                 845             


Gly Asp Met Ser Ser Asp Asn Asp Ser Tyr His Ser Asp Glu Phe Leu 
    850                 855                 860                 


Thr Asn Ser Lys Ser Asp Glu Asp Arg Gln Leu Ala Asn Ser Leu Glu 
865                 870                 875                 880 


Ser Val Gly Pro Ile Asp Tyr Val Leu Pro Ser Cys Gly Ile Ile Ala 
                885                 890                 895     


Ser Ala Pro Arg Leu Gly Ser Arg Ser Gln Ser Leu Ser Ser Thr Asp 
            900                 905                 910         


Ser Ser Val His Ala Pro Ser Glu Ile Thr Val Ala His Gly Ser Gly 
        915                 920                 925             


Leu Gly Lys Gly Gln Glu Ser Pro Leu Lys Lys Ser Pro Ser Ala Gly 
    930                 935                 940                 


Asp Val His Ile Leu Thr Gly Phe Ala Lys Pro Met Asp Ile Tyr Cys 
945                 950                 955                 960 


His Arg Phe Val Gln Asp Ala Gln Asn Lys Val Thr His Leu Ser Glu 
                965                 970                 975     


Thr Arg Ser Val Ser Gln Gln Ala Ser Gln Glu Arg Asn Gln Met Thr 
            980                 985                 990         


Asn Gln Val Ser Asn Glu Thr Gln  Ser Glu Ser Thr Glu  Gln Thr Pro 
        995                 1000                 1005             


Ser Arg  Pro Ser Gln Leu Asp  Val Ser Leu Ser Ala  Thr Gly Pro 
    1010                 1015                 1020             


Gln Phe  Leu Ser Val Glu Pro  Ala His Ser Val Ala  Ser Gln Lys 
    1025                 1030                 1035             


Thr Pro  Thr Ser Ala Ser Ser  Met Leu Glu Leu Glu  Thr Gly Leu 
    1040                 1045                 1050             


His Val  Thr Pro Ser Pro Ser  Glu Ser Ser Ser Ser  Arg Ala Val 
    1055                 1060                 1065             


Ser Pro  Phe Ala Lys Ile Arg  Ser Ser Met Val Gln  Val Ala Ser 
    1070                 1075                 1080             


Ile Thr  Gln Ala Gly Leu Thr  His Gly Ile Asn Phe  Ala Val Ser 
    1085                 1090                 1095             


Lys Val  Gln Lys Ser Pro Pro  Glu Pro Glu Ile Ile  Asn Gln Val 
    1100                 1105                 1110             


Gln Gln  Asn Glu Leu Lys Lys  Met Phe Ile Gln Cys  Gln Thr Arg 
    1115                 1120                 1125             


Ile Ile  Gln Ile 
    1130         


<210>  49
<211>  2243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49

Met Asn Ile Ile Arg Glu Asn Lys Asp Leu Ala Cys Phe Tyr Thr Thr 
1               5                   10                  15      


Lys His Ser Trp Arg Gly Lys Tyr Lys Arg Val Phe Ser Val Gly Thr 
            20                  25                  30          


His Ala Ile Thr Thr Tyr Asn Pro Asn Thr Leu Glu Val Thr Asn Gln 
        35                  40                  45              


Trp Pro Tyr Gly Asp Ile Cys Ser Ile Ser Pro Val Gly Lys Gly Gln 
    50                  55                  60                  


Gly Thr Glu Phe Asn Leu Thr Phe Arg Lys Gly Ser Gly Lys Lys Ser 
65                  70                  75                  80  


Glu Thr Leu Lys Phe Ser Thr Glu His Arg Thr Glu Leu Leu Thr Glu 
                85                  90                  95      


Ala Leu Arg Phe Arg Thr Asp Phe Ser Glu Gly Lys Ile Thr Gly Arg 
            100                 105                 110         


Arg Tyr Asn Cys Tyr Lys His His Trp Ser Asp Ser Arg Lys Pro Val 
        115                 120                 125             


Ile Leu Glu Val Thr Pro Gly Gly Phe Asp Gln Ile Asn Pro Ala Thr 
    130                 135                 140                 


Asn Arg Val Leu Cys Ser Tyr Asp Tyr Arg Asn Ile Glu Gly Phe Val 
145                 150                 155                 160 


Asp Leu Ser Asp Tyr Gln Gly Gly Phe Cys Ile Leu Tyr Gly Gly Phe 
                165                 170                 175     


Ser Arg Leu His Leu Phe Ala Ser Glu Gln Arg Glu Glu Ile Ile Lys 
            180                 185                 190         


Ser Ala Ile Asp His Ala Gly Asn Tyr Ile Gly Ile Ser Leu Arg Ile 
        195                 200                 205             


Arg Lys Glu Pro Leu Glu Phe Glu Gln Tyr Leu Asn Leu Arg Phe Gly 
    210                 215                 220                 


Lys Tyr Ser Thr Asp Glu Ser Ile Thr Ser Leu Ala Glu Phe Val Val 
225                 230                 235                 240 


Gln Lys Ile Ser Pro Arg His Ser Glu Pro Val Lys Arg Val Leu Ala 
                245                 250                 255     


Leu Thr Glu Thr Cys Leu Val Glu Arg Asp Pro Ala Thr Tyr Asn Ile 
            260                 265                 270         


Ala Thr Leu Lys Pro Leu Gly Glu Val Phe Ala Leu Val Cys Asp Ser 
        275                 280                 285             


Glu Asn Pro Gln Leu Phe Thr Ile Glu Phe Ile Lys Gly Gln Val Arg 
    290                 295                 300                 


Lys Tyr Ser Ser Thr Glu Arg Asp Ser Leu Leu Ala Ser Leu Leu Asp 
305                 310                 315                 320 


Gly Val Arg Ala Ser Gly Asn Arg Asp Val Cys Val Lys Met Thr Pro 
                325                 330                 335     


Thr His Lys Gly Gln Arg Trp Gly Leu Leu Ser Met Pro Val Asp Glu 
            340                 345                 350         


Glu Val Glu Ser Leu His Leu Arg Phe Leu Ala Thr Pro Pro Asn Gly 
        355                 360                 365             


Asn Phe Ala Asp Ala Val Phe Arg Phe Asn Ala Asn Ile Ser Tyr Ser 
    370                 375                 380                 


Gly Val Leu His Ala Val Thr Gln Asp Gly Leu Phe Ser Glu Asn Lys 
385                 390                 395                 400 


Glu Lys Leu Ile Asn Asn Ala Ile Thr Ala Leu Leu Ser Gln Glu Gly 
                405                 410                 415     


Asp Val Val Ala Ser Asn Ala Glu Leu Glu Ser Gln Phe Gln Ala Val 
            420                 425                 430         


Arg Arg Leu Val Ala Ser Lys Ala Gly Phe Leu Ala Phe Thr Gln Leu 
        435                 440                 445             


Pro Lys Phe Arg Glu Arg Leu Gly Val Lys Val Val Lys Ala Leu Lys 
    450                 455                 460                 


Arg Ser Asn Asn Gly Ile Ile His Ala Ala Val Asp Met Leu Cys Ala 
465                 470                 475                 480 


Leu Met Cys Pro Met His Asp Asp Tyr Asp Leu Arg Gln Glu Gln Leu 
                485                 490                 495     


Asn Lys Ala Ser Leu Leu Ser Ser Lys Lys Phe Leu Glu Asn Leu Leu 
            500                 505                 510         


Glu Lys Phe Asn Ser His Val Asp His Gly Thr Gly Ala Leu Val Ile 
        515                 520                 525             


Ser Ser Leu Leu Asp Phe Leu Thr Phe Ala Leu Cys Ala Pro Tyr Ser 
    530                 535                 540                 


Glu Thr Thr Glu Gly Gln Gln Phe Asp Met Leu Leu Glu Met Val Ala 
545                 550                 555                 560 


Ser Asn Gly Arg Thr Leu Phe Lys Leu Phe Gln His Pro Ser Met Ala 
                565                 570                 575     


Ile Ile Lys Gly Ala Gly Leu Val Met Lys Ala Ile Ile Glu Glu Gly 
            580                 585                 590         


Asp Lys Glu Ile Ala Thr Lys Met Gln Glu Leu Ala Leu Ser Glu Gly 
        595                 600                 605             


Ala Leu Pro Arg His Leu His Thr Ala Met Phe Thr Ile Ser Ser Asp 
    610                 615                 620                 


Gln Arg Met Leu Thr Asn Arg Gln Leu Ser Arg His Leu Val Gly Leu 
625                 630                 635                 640 


Trp Thr Ala Asp Asn Ala Thr Ala Thr Asn Leu Leu Lys Arg Ile Leu 
                645                 650                 655     


Pro Pro Gly Leu Leu Ala Tyr Leu Glu Ser Ser Asp Leu Val Pro Glu 
            660                 665                 670         


Lys Asp Ala Asp Arg Met His Val Arg Asp Asn Val Lys Ile Ala Met 
        675                 680                 685             


Asp Gln Tyr Gly Lys Phe Asn Lys Val Pro Glu Trp Gln Arg Leu Ala 
    690                 695                 700                 


Gly Lys Ala Ala Lys Glu Val Glu Lys Phe Ala Lys Glu Lys Val Asp 
705                 710                 715                 720 


Leu Val Leu Met His Trp Arg Asp Arg Met Gly Ile Ala Gln Lys Glu 
                725                 730                 735     


Asn Ile Asn Gln Lys Pro Val Val Leu Arg Lys Arg Arg Gln Arg Ile 
            740                 745                 750         


Lys Ile Glu Ala Asn Trp Asp Leu Phe Tyr Tyr Arg Phe Gly Gln Asp 
        755                 760                 765             


His Ala Arg Ser Asn Leu Ile Trp Asn Phe Lys Thr Arg Glu Glu Leu 
    770                 775                 780                 


Lys Asp Thr Leu Glu Ser Glu Met Arg Ala Phe Asn Ile Asp Arg Glu 
785                 790                 795                 800 


Leu Gly Ser Ala Asn Val Ile Ser Trp Asn His His Glu Phe Glu Val 
                805                 810                 815     


Lys Tyr Glu Cys Leu Ala Glu Glu Ile Lys Ile Gly Asp Tyr Tyr Leu 
            820                 825                 830         


Arg Leu Leu Leu Glu Glu Asp Glu Asn Glu Glu Ser Gly Ser Ile Lys 
        835                 840                 845             


Arg Ser Tyr Glu Phe Phe Asn Glu Leu Tyr His Arg Phe Leu Leu Thr 
    850                 855                 860                 


Pro Lys Val Asn Met Lys Cys Leu Cys Leu Gln Ala Leu Ala Ile Val 
865                 870                 875                 880 


Tyr Gly Arg Cys His Glu Glu Ile Gly Pro Phe Thr Asp Thr Arg Tyr 
                885                 890                 895     


Ile Ile Gly Met Leu Glu Arg Cys Thr Asp Lys Leu Glu Arg Asp Arg 
            900                 905                 910         


Leu Ile Leu Phe Leu Asn Lys Leu Ile Leu Asn Lys Lys Asn Val Lys 
        915                 920                 925             


Asp Leu Met Asp Ser Asn Gly Ile Arg Ile Leu Val Asp Leu Leu Thr 
    930                 935                 940                 


Leu Ala His Leu His Val Ser Arg Ala Thr Val Pro Leu Gln Ser Asn 
945                 950                 955                 960 


Val Ile Glu Ala Ala Pro Asp Met Lys Arg Glu Ser Glu Lys Glu Trp 
                965                 970                 975     


Tyr Phe Gly Asn Ala Asp Lys Glu Arg Ser Gly Pro Tyr Gly Phe His 
            980                 985                 990         


Glu Met Gln Glu Leu Trp Thr Lys  Gly Met Leu Asn Ala  Lys Thr Arg 
        995                 1000                 1005             


Cys Trp  Ala Gln Gly Met Asp  Gly Trp Arg Pro Leu  Gln Ser Ile 
    1010                 1015                 1020             


Pro Gln  Leu Lys Trp Cys Leu  Leu Ala Ser Gly Gln  Ala Val Leu 
    1025                 1030                 1035             


Asn Glu  Thr Asp Leu Ala Thr  Leu Ile Leu Asn Met  Leu Ile Thr 
    1040                 1045                 1050             


Met Cys  Gly Tyr Phe Pro Ser  Arg Asp Gln Asp Asn  Ala Ile Ile 
    1055                 1060                 1065             


Arg Pro  Leu Pro Lys Val Lys  Arg Leu Leu Ser Asp  Ser Thr Cys 
    1070                 1075                 1080             


Leu Pro  His Ile Ile Gln Leu  Leu Leu Thr Phe Asp  Pro Ile Leu 
    1085                 1090                 1095             


Val Glu  Lys Val Ala Ile Leu  Leu Tyr His Ile Met  Gln Asp Asn 
    1100                 1105                 1110             


Pro Gln  Leu Pro Arg Leu Tyr  Leu Ser Gly Val Phe  Phe Phe Ile 
    1115                 1120                 1125             


Met Met  Tyr Thr Gly Ser Asn  Val Leu Pro Val Ala  Arg Phe Leu 
    1130                 1135                 1140             


Lys Tyr  Thr His Thr Lys Gln  Ala Phe Lys Ser Glu  Glu Thr Lys 
    1145                 1150                 1155             


Gly Gln  Asp Ile Phe Gln Arg  Ser Ile Leu Gly His  Ile Leu Pro 
    1160                 1165                 1170             


Glu Ala  Met Val Cys Tyr Leu  Glu Asn Tyr Glu Pro  Glu Lys Phe 
    1175                 1180                 1185             


Ser Glu  Ile Phe Leu Gly Glu  Phe Asp Thr Pro Glu  Ala Ile Trp 
    1190                 1195                 1200             


Ser Ser  Glu Met Arg Arg Leu  Met Ile Glu Lys Ile  Ala Ala His 
    1205                 1210                 1215             


Leu Ala  Asp Phe Thr Pro Arg  Leu Gln Ser Asn Thr  Arg Ala Leu 
    1220                 1225                 1230             


Tyr Gln  Tyr Cys Pro Ile Pro  Ile Ile Asn Tyr Pro  Gln Leu Glu 
    1235                 1240                 1245             


Asn Glu  Leu Phe Cys Asn Ile  Tyr Tyr Leu Lys Gln  Leu Cys Asp 
    1250                 1255                 1260             


Thr Leu  Arg Phe Pro Asp Trp  Pro Ile Lys Asp Pro  Val Lys Leu 
    1265                 1270                 1275             


Leu Lys  Asp Thr Leu Asp Ala  Trp Lys Lys Glu Val  Glu Lys Lys 
    1280                 1285                 1290             


Pro Pro  Met Met Ser Ile Asp  Asp Ala Tyr Glu Val  Leu Asn Leu 
    1295                 1300                 1305             


Pro Gln  Gly Gln Gly Pro His  Asp Glu Ser Lys Ile  Arg Lys Ala 
    1310                 1315                 1320             


Tyr Phe  Arg Leu Ala Gln Lys  Tyr His Pro Asp Lys  Asn Pro Glu 
    1325                 1330                 1335             


Gly Arg  Asp Met Phe Glu Lys  Val Asn Lys Ala Tyr  Glu Phe Leu 
    1340                 1345                 1350             


Cys Thr  Lys Ser Ala Lys Ile  Val Asp Gly Pro Asp  Pro Glu Asn 
    1355                 1360                 1365             


Ile Ile  Leu Ile Leu Lys Thr  Gln Ser Ile Leu Phe  Asn Arg His 
    1370                 1375                 1380             


Lys Glu  Asp Leu Gln Pro Tyr  Lys Tyr Ala Gly Tyr  Pro Met Leu 
    1385                 1390                 1395             


Ile Arg  Thr Ile Thr Met Glu  Thr Ser Asp Asp Leu  Leu Phe Ser 
    1400                 1405                 1410             


Lys Glu  Ser Pro Leu Leu Pro  Ala Ala Thr Glu Leu  Ala Phe His 
    1415                 1420                 1425             


Thr Val  Asn Cys Ser Ala Leu  Asn Ala Glu Glu Leu  Arg Arg Glu 
    1430                 1435                 1440             


Asn Gly  Leu Glu Val Leu Gln  Glu Ala Phe Ser Arg  Cys Val Ala 
    1445                 1450                 1455             


Val Leu  Thr Arg Ala Ser Lys  Pro Ser Asp Met Ser  Val Gln Val 
    1460                 1465                 1470             


Cys Gly  Tyr Ile Ser Lys Cys  Tyr Ser Val Ala Ala  Gln Phe Glu 
    1475                 1480                 1485             


Glu Cys  Arg Glu Lys Ile Thr  Glu Met Pro Ser Ile  Ile Lys Asp 
    1490                 1495                 1500             


Leu Cys  Arg Val Leu Tyr Phe  Gly Lys Ser Ile Pro  Arg Val Ala 
    1505                 1510                 1515             


Ala Leu  Gly Val Glu Cys Val  Ser Ser Phe Ala Val  Asp Phe Trp 
    1520                 1525                 1530             


Leu Gln  Thr His Leu Phe Gln  Ala Gly Ile Leu Trp  Tyr Leu Leu 
    1535                 1540                 1545             


Gly Phe  Leu Phe Asn Tyr Asp  Tyr Thr Leu Glu Glu  Ser Gly Ile 
    1550                 1555                 1560             


Gln Lys  Ser Glu Glu Thr Asn  Gln Gln Glu Val Ala  Asn Ser Leu 
    1565                 1570                 1575             


Ala Lys  Leu Ser Val His Ala  Leu Ser Arg Leu Gly  Gly Tyr Leu 
    1580                 1585                 1590             


Ala Glu  Glu Gln Ala Thr Pro  Glu Asn Pro Thr Ile  Arg Lys Ser 
    1595                 1600                 1605             


Leu Ala  Gly Met Leu Thr Pro  Tyr Val Ala Arg Lys  Leu Ala Val 
    1610                 1615                 1620             


Ala Ser  Val Thr Glu Ile Leu  Lys Met Leu Asn Ser  Asn Thr Glu 
    1625                 1630                 1635             


Ser Pro  Tyr Leu Ile Trp Asn  Asn Ser Thr Arg Ala  Glu Leu Leu 
    1640                 1645                 1650             


Glu Phe  Leu Glu Ser Gln Gln  Glu Asn Met Ile Lys  Lys Gly Asp 
    1655                 1660                 1665             


Cys Asp  Lys Thr Tyr Gly Ser  Glu Phe Val Tyr Ser  Asp His Ala 
    1670                 1675                 1680             


Lys Glu  Leu Ile Val Gly Glu  Ile Phe Val Arg Val  Tyr Asn Glu 
    1685                 1690                 1695             


Val Pro  Thr Phe Gln Leu Glu  Val Pro Lys Ala Phe  Ala Ala Ser 
    1700                 1705                 1710             


Leu Leu  Asp Tyr Ile Gly Ser  Gln Ala Gln Tyr Leu  His Thr Phe 
    1715                 1720                 1725             


Met Ala  Ile Thr His Ala Ala  Lys Val Glu Ser Glu  Gln His Gly 
    1730                 1735                 1740             


Asp Arg  Leu Pro Arg Val Glu  Met Ala Leu Glu Ala  Leu Arg Asn 
    1745                 1750                 1755             


Val Ile  Lys Tyr Asn Pro Gly  Ser Glu Ser Glu Cys  Ile Gly His 
    1760                 1765                 1770             


Phe Lys  Leu Ile Phe Ser Leu  Leu Arg Val His Gly  Ala Gly Gln 
    1775                 1780                 1785             


Val Gln  Gln Leu Ala Leu Glu  Val Val Asn Ile Val  Thr Ser Asn 
    1790                 1795                 1800             


Gln Asp  Cys Val Asn Asn Ile  Ala Glu Ser Met Val  Leu Ser Ser 
    1805                 1810                 1815             


Leu Leu  Ala Leu Leu His Ser  Leu Pro Ser Ser Arg  Gln Leu Val 
    1820                 1825                 1830             


Leu Glu  Thr Leu Tyr Ala Leu  Thr Ser Ser Thr Lys  Ile Ile Lys 
    1835                 1840                 1845             


Glu Ala  Met Ala Lys Gly Ala  Leu Ile Tyr Leu Leu  Asp Met Phe 
    1850                 1855                 1860             


Cys Asn  Ser Thr His Pro Gln  Val Arg Ala Gln Thr  Ala Glu Leu 
    1865                 1870                 1875             


Phe Ala  Lys Met Thr Ala Asp  Lys Leu Ile Gly Pro  Lys Val Arg 
    1880                 1885                 1890             


Ile Thr  Leu Met Lys Phe Leu  Pro Ser Val Phe Met  Asp Ala Met 
    1895                 1900                 1905             


Arg Asp  Asn Pro Glu Ala Ala  Val His Ile Phe Glu  Gly Thr His 
    1910                 1915                 1920             


Glu Asn  Pro Glu Leu Ile Trp  Asn Asp Asn Ser Arg  Asp Lys Val 
    1925                 1930                 1935             


Ser Thr  Thr Val Arg Glu Met  Met Leu Glu His Phe  Lys Asn Gln 
    1940                 1945                 1950             


Gln Asp  Asn Pro Glu Ala Asn  Trp Lys Leu Pro Glu  Asp Phe Ala 
    1955                 1960                 1965             


Val Val  Phe Gly Glu Ala Glu  Gly Glu Leu Ala Val  Gly Gly Val 
    1970                 1975                 1980             


Phe Leu  Arg Ile Phe Ile Ala  Gln Pro Ala Trp Val  Leu Arg Lys 
    1985                 1990                 1995             


Pro Arg  Glu Phe Leu Ile Ala  Leu Leu Glu Lys Leu  Thr Glu Leu 
    2000                 2005                 2010             


Leu Glu  Lys Asn Asn Pro His  Gly Glu Thr Leu Glu  Thr Leu Thr 
    2015                 2020                 2025             


Met Ala  Thr Val Cys Leu Phe  Ser Ala Gln Pro Gln  Leu Ala Asp 
    2030                 2035                 2040             


Gln Val  Pro Pro Leu Gly His  Leu Pro Lys Val Ile  Gln Ala Met 
    2045                 2050                 2055             


Asn His  Arg Asn Asn Ala Ile  Pro Lys Ser Ala Ile  Arg Val Ile 
    2060                 2065                 2070             


His Ala  Leu Ser Glu Asn Glu  Leu Cys Val Arg Ala  Met Ala Ser 
    2075                 2080                 2085             


Leu Glu  Thr Ile Gly Pro Leu  Met Asn Gly Met Lys  Lys Arg Ala 
    2090                 2095                 2100             


Asp Thr  Val Gly Leu Ala Cys  Glu Ala Ile Asn Arg  Met Phe Gln 
    2105                 2110                 2115             


Lys Glu  Gln Ser Glu Leu Val  Ala Gln Ala Leu Lys  Ala Asp Leu 
    2120                 2125                 2130             


Val Pro  Tyr Leu Leu Lys Leu  Leu Glu Gly Ile Gly  Leu Glu Asn 
    2135                 2140                 2145             


Leu Asp  Ser Pro Ala Ala Thr  Lys Ala Gln Ile Val  Lys Ala Leu 
    2150                 2155                 2160             


Lys Ala  Met Thr Arg Ser Leu  Gln Tyr Gly Glu Gln  Val Asn Glu 
    2165                 2170                 2175             


Ile Leu  Cys Arg Ser Ser Val  Trp Ser Ala Phe Lys  Asp Gln Lys 
    2180                 2185                 2190             


His Asp  Leu Phe Ile Ser Glu  Ser Gln Thr Ala Gly  Tyr Leu Thr 
    2195                 2200                 2205             


Gly Pro  Gly Val Ala Gly Tyr  Leu Thr Ala Gly Thr  Ser Thr Ser 
    2210                 2215                 2220             


Val Met  Ser Asn Leu Pro Pro  Pro Val Asp His Glu  Ala Gly Asp 
    2225                 2230                 2235             


Leu Gly  Tyr Gln Thr 
    2240             


<210>  50
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Met Glu Lys Gly Pro Val Arg Ala Pro Ala Glu Lys Pro Arg Gly Ala 
1               5                   10                  15      


Arg Cys Ser Asn Gly Phe Pro Glu Arg Asp Pro Pro Arg Pro Gly Pro 
            20                  25                  30          


Ser Arg Pro Ala Glu Lys Pro Pro Arg Pro Glu Ala Lys Ser Ala Gln 
        35                  40                  45              


Pro Ala Asp Gly Trp Lys Gly Glu Arg Pro Arg Ser Glu Glu Asp Asn 
    50                  55                  60                  


Glu Leu Asn Leu Pro Asn Leu Ala Ala Ala Tyr Ser Ser Ile Leu Ser 
65                  70                  75                  80  


Ser Leu Gly Glu Asn Pro Gln Arg Gln Gly Leu Leu Lys Thr Pro Trp 
                85                  90                  95      


Arg Ala Ala Ser Ala Met Gln Phe Phe Thr Lys Gly Tyr Gln Glu Thr 
            100                 105                 110         


Ile Ser Asp Val Leu Asn Asp Ala Ile Phe Asp Glu Asp His Asp Glu 
        115                 120                 125             


Met Val Ile Val Lys Asp Ile Asp Met Phe Ser Met Cys Glu His His 
    130                 135                 140                 


Leu Val Pro Phe Val Gly Lys Val His Ile Gly Tyr Leu Pro Asn Lys 
145                 150                 155                 160 


Gln Val Leu Gly Leu Ser Lys Leu Ala Arg Ile Val Glu Ile Tyr Ser 
                165                 170                 175     


Arg Arg Leu Gln Val Gln Glu Arg Leu Thr Lys Gln Ile Ala Val Ala 
            180                 185                 190         


Ile Thr Glu Ala Leu Arg Pro Ala Gly Val Gly Val Val Val Glu Ala 
        195                 200                 205             


Thr His Met Cys Met Val Met Arg Gly Val Gln Lys Met Asn Ser Lys 
    210                 215                 220                 


Thr Val Thr Ser Thr Met Leu Gly Val Phe Arg Glu Asp Pro Lys Thr 
225                 230                 235                 240 


Arg Glu Glu Phe Leu Thr Leu Ile Arg Ser 
                245                 250 


<210>  51
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51

Met Glu Tyr Met Ala Glu Ser Thr Asp Arg Ser Pro Gly His Ile Leu 
1               5                   10                  15      


Cys Cys Glu Cys Gly Val Pro Ile Ser Pro Asn Pro Ala Asn Ile Cys 
            20                  25                  30          


Val Ala Cys Leu Arg Ser Lys Val Asp Ile Ser Gln Gly Ile Pro Lys 
        35                  40                  45              


Gln Val Ser Ile Ser Phe Cys Lys Gln Cys Gln Arg Tyr Phe Gln Pro 
    50                  55                  60                  


Pro Gly Thr Trp Ile Gln Cys Ala Leu Glu Ser Arg Glu Leu Leu Ala 
65                  70                  75                  80  


Leu Cys Leu Lys Lys Ile Lys Ala Pro Leu Ser Lys Val Arg Leu Val 
                85                  90                  95      


Asp Ala Gly Phe Val Trp Thr Glu Pro His Ser Lys Arg Leu Lys Val 
            100                 105                 110         


Lys Leu Thr Ile Gln Lys Glu Val Met Asn Gly Ala Ile Leu Gln Gln 
        115                 120                 125             


Val Phe Val Val Asp Tyr Val Val Gln Ser Gln Met Cys Gly Asp Cys 
    130                 135                 140                 


His Arg Val Glu Ala Lys Asp Phe Trp Lys Ala Val Ile Gln Val Arg 
145                 150                 155                 160 


Gln Lys Thr Leu His Lys Lys Thr Phe Tyr Tyr Leu Glu Gln Leu Ile 
                165                 170                 175     


Leu Lys Tyr Gly Met His Gln Asn Thr Leu Arg Ile Lys Glu Ile His 
            180                 185                 190         


Asp Gly Leu Asp Phe Tyr Tyr Ser Ser Lys Gln His Ala Gln Lys Met 
        195                 200                 205             


Val Glu Phe Leu Gln Cys Thr Val Pro Cys Arg Tyr Lys Ala Ser Gln 
    210                 215                 220                 


Arg Leu Ile Ser Gln Asp Ile His Ser Asn Thr Tyr Asn Tyr Lys Ser 
225                 230                 235                 240 


Thr Phe Ser Val Glu Ile Val Pro Ile Cys Lys Asp Asn Val Val Cys 
                245                 250                 255     


Leu Ser Pro Lys Leu Ala Gln Ser Leu Gly Asn Met Asn Gln Ile Cys 
            260                 265                 270         


Val Cys Ile Arg Val Thr Ser Ala Ile His Leu Ile Asp Pro Asn Thr 
        275                 280                 285             


Leu Gln Val Ala Asp Ile Asp Gly Ser Thr Phe Trp Ser His Pro Phe 
    290                 295                 300                 


Asn Ser Leu Cys His Pro Lys Gln Leu Glu Glu Phe Ile Val Met Glu 
305                 310                 315                 320 


Cys Ser Ile Val Gln Asp Ile Lys Arg Ala Ala Gly Ala Gly Met Ile 
                325                 330                 335     


Ser Lys Lys His Thr Leu Gly Glu Val Trp Val Gln Lys Thr Ser Glu 
            340                 345                 350         


Met Asn Thr Asp Lys Gln Tyr Phe Cys Arg Thr His Leu Gly His Leu 
        355                 360                 365             


Leu Asn Pro Gly Asp Leu Val Leu Gly Phe Asp Leu Ala Asn Cys Asn 
    370                 375                 380                 


Leu Asn Asp Glu His Val Asn Lys Met Asn Ser Asp Arg Val Pro Asp 
385                 390                 395                 400 


Val Val Leu Ile Lys Lys Ser Tyr Asp Arg Thr Lys Arg Gln Arg Arg 
                405                 410                 415     


Arg Asn Trp Lys Leu Lys Glu Leu Ala Arg Glu Arg Glu Asn Met Asp 
            420                 425                 430         


Thr Asp Asp Glu Arg Gln Tyr Gln Asp Phe Leu Glu Asp Leu Glu Glu 
        435                 440                 445             


Asp Glu Ala Ile Arg Lys Asn Val Asn Ile Tyr Arg Asp Ser Ala Ile 
    450                 455                 460                 


Pro Val Glu Ser Asp Thr Asp Asp Glu Gly Ala Pro Arg Ile Ser Leu 
465                 470                 475                 480 


Ala Glu Met Leu Glu Asp Leu His Ile Ser Gln Asp Ala Thr Gly Glu 
                485                 490                 495     


Glu Gly Ala Ser Met Leu Thr 
            500             


<210>  52
<211>  1055
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Met Thr Val Glu Gln Asn Val Leu Gln Gln Ser Ala Ala Gln Lys His 
1               5                   10                  15      


Gln Gln Thr Phe Leu Asn Gln Leu Arg Glu Ile Thr Gly Ile Asn Asp 
            20                  25                  30          


Thr Gln Ile Leu Gln Gln Ala Leu Lys Asp Ser Asn Gly Asn Leu Glu 
        35                  40                  45              


Leu Ala Val Ala Phe Leu Thr Ala Lys Asn Ala Lys Thr Pro Gln Gln 
    50                  55                  60                  


Glu Glu Thr Thr Tyr Tyr Gln Thr Ala Leu Pro Gly Asn Asp Arg Tyr 
65                  70                  75                  80  


Ile Ser Val Gly Ser Gln Ala Asp Thr Asn Val Ile Asp Leu Thr Gly 
                85                  90                  95      


Asp Asp Lys Asp Asp Leu Gln Arg Ala Ile Ala Leu Ser Leu Ala Glu 
            100                 105                 110         


Ser Asn Arg Ala Phe Arg Glu Thr Gly Ile Thr Asp Glu Glu Gln Ala 
        115                 120                 125             


Ile Ser Arg Val Leu Glu Ala Ser Ile Ala Glu Asn Lys Ala Cys Leu 
    130                 135                 140                 


Lys Arg Thr Pro Thr Glu Val Trp Arg Asp Ser Arg Asn Pro Tyr Asp 
145                 150                 155                 160 


Arg Lys Arg Gln Asp Lys Ala Pro Val Gly Leu Lys Asn Val Gly Asn 
                165                 170                 175     


Thr Cys Trp Phe Ser Ala Val Ile Gln Ser Leu Phe Asn Leu Leu Glu 
            180                 185                 190         


Phe Arg Arg Leu Val Leu Asn Tyr Lys Pro Pro Ser Asn Ala Gln Asp 
        195                 200                 205             


Leu Pro Arg Asn Gln Lys Glu His Arg Asn Leu Pro Phe Met Arg Glu 
    210                 215                 220                 


Leu Arg Tyr Leu Phe Ala Leu Leu Val Gly Thr Lys Arg Lys Tyr Val 
225                 230                 235                 240 


Asp Pro Ser Arg Ala Val Glu Ile Leu Lys Asp Ala Phe Lys Ser Asn 
                245                 250                 255     


Asp Ser Gln Gln Gln Asp Val Ser Glu Phe Thr His Lys Leu Leu Asp 
            260                 265                 270         


Trp Leu Glu Asp Ala Phe Gln Met Lys Ala Glu Glu Glu Thr Asp Glu 
        275                 280                 285             


Glu Lys Pro Lys Asn Pro Met Val Glu Leu Phe Tyr Gly Arg Phe Leu 
    290                 295                 300                 


Ala Val Gly Val Leu Glu Gly Lys Lys Phe Glu Asn Thr Glu Met Phe 
305                 310                 315                 320 


Gly Gln Tyr Pro Leu Gln Val Asn Gly Phe Lys Asp Leu His Glu Cys 
                325                 330                 335     


Leu Glu Ala Ala Met Ile Glu Gly Glu Ile Glu Ser Leu His Ser Glu 
            340                 345                 350         


Asn Ser Gly Lys Ser Gly Gln Glu His Trp Phe Thr Glu Leu Pro Pro 
        355                 360                 365             


Val Leu Thr Phe Glu Leu Ser Arg Phe Glu Phe Asn Gln Ala Leu Gly 
    370                 375                 380                 


Arg Pro Glu Lys Ile His Asn Lys Leu Glu Phe Pro Gln Val Leu Tyr 
385                 390                 395                 400 


Leu Asp Arg Tyr Met His Arg Asn Arg Glu Ile Thr Arg Ile Lys Arg 
                405                 410                 415     


Glu Glu Ile Lys Arg Leu Lys Asp Tyr Leu Thr Val Leu Gln Gln Arg 
            420                 425                 430         


Leu Glu Arg Tyr Leu Ser Tyr Gly Ser Gly Pro Lys Arg Phe Pro Leu 
        435                 440                 445             


Val Asp Val Leu Gln Tyr Ala Leu Glu Phe Ala Ser Ser Lys Pro Val 
    450                 455                 460                 


Cys Thr Ser Pro Val Asp Asp Ile Asp Ala Ser Ser Pro Pro Ser Gly 
465                 470                 475                 480 


Ser Ile Pro Ser Gln Thr Leu Pro Ser Thr Thr Glu Gln Gln Gly Ala 
                485                 490                 495     


Leu Ser Ser Glu Leu Pro Ser Thr Ser Pro Ser Ser Val Ala Ala Ile 
            500                 505                 510         


Ser Ser Arg Ser Val Ile His Lys Pro Phe Thr Gln Ser Arg Ile Pro 
        515                 520                 525             


Pro Asp Leu Pro Met His Pro Ala Pro Arg His Ile Thr Glu Glu Glu 
    530                 535                 540                 


Leu Ser Val Leu Glu Ser Cys Leu His Arg Trp Arg Thr Glu Ile Glu 
545                 550                 555                 560 


Asn Asp Thr Arg Asp Leu Gln Glu Ser Ile Ser Arg Ile His Arg Thr 
                565                 570                 575     


Ile Glu Leu Met Tyr Ser Asp Lys Ser Met Ile Gln Val Pro Tyr Arg 
            580                 585                 590         


Leu His Ala Val Leu Val His Glu Gly Gln Ala Asn Ala Gly His Tyr 
        595                 600                 605             


Trp Ala Tyr Ile Phe Asp His Arg Glu Ser Arg Trp Met Lys Tyr Asn 
    610                 615                 620                 


Asp Ile Ala Val Thr Lys Ser Ser Trp Glu Glu Leu Val Arg Asp Ser 
625                 630                 635                 640 


Phe Gly Gly Tyr Arg Asn Ala Ser Ala Tyr Cys Leu Met Tyr Ile Asn 
                645                 650                 655     


Asp Lys Ala Gln Phe Leu Ile Gln Glu Glu Phe Asn Lys Glu Thr Gly 
            660                 665                 670         


Gln Pro Leu Val Gly Ile Glu Thr Leu Pro Pro Asp Leu Arg Asp Phe 
        675                 680                 685             


Val Glu Glu Asp Asn Gln Arg Phe Glu Lys Glu Leu Glu Glu Trp Asp 
    690                 695                 700                 


Ala Gln Leu Ala Gln Lys Ala Leu Gln Glu Lys Leu Leu Ala Ser Gln 
705                 710                 715                 720 


Lys Leu Arg Glu Ser Glu Thr Ser Val Thr Thr Ala Gln Ala Ala Gly 
                725                 730                 735     


Asp Pro Glu Tyr Leu Glu Gln Pro Ser Arg Ser Asp Phe Ser Lys His 
            740                 745                 750         


Leu Lys Glu Glu Thr Ile Gln Ile Ile Thr Lys Ala Ser His Glu His 
        755                 760                 765             


Glu Asp Lys Ser Pro Glu Thr Val Leu Gln Ser Ala Ile Lys Leu Glu 
    770                 775                 780                 


Tyr Ala Arg Leu Val Lys Leu Ala Gln Glu Asp Thr Pro Pro Glu Thr 
785                 790                 795                 800 


Asp Tyr Arg Leu His His Val Val Val Tyr Phe Ile Gln Asn Gln Ala 
                805                 810                 815     


Pro Lys Lys Ile Ile Glu Lys Thr Leu Leu Glu Gln Phe Gly Asp Arg 
            820                 825                 830         


Asn Leu Ser Phe Asp Glu Arg Cys His Asn Ile Met Lys Val Ala Gln 
        835                 840                 845             


Ala Lys Leu Glu Met Ile Lys Pro Glu Glu Val Asn Leu Glu Glu Tyr 
    850                 855                 860                 


Glu Glu Trp His Gln Asp Tyr Arg Lys Phe Arg Glu Thr Thr Met Tyr 
865                 870                 875                 880 


Leu Ile Ile Gly Leu Glu Asn Phe Gln Arg Glu Ser Tyr Ile Asp Ser 
                885                 890                 895     


Leu Leu Phe Leu Ile Cys Ala Tyr Gln Asn Asn Lys Glu Leu Leu Ser 
            900                 905                 910         


Lys Gly Leu Tyr Arg Gly His Asp Glu Glu Leu Ile Ser His Tyr Arg 
        915                 920                 925             


Arg Glu Cys Leu Leu Lys Leu Asn Glu Gln Ala Ala Glu Leu Phe Glu 
    930                 935                 940                 


Ser Gly Glu Asp Arg Glu Val Asn Asn Gly Leu Ile Ile Met Asn Glu 
945                 950                 955                 960 


Phe Ile Val Pro Phe Leu Pro Leu Leu Leu Val Asp Glu Met Glu Glu 
                965                 970                 975     


Lys Asp Ile Leu Ala Val Glu Asp Met Arg Asn Arg Trp Cys Ser Tyr 
            980                 985                 990         


Leu Gly Gln Glu Met Glu Pro His  Leu Gln Glu Lys Leu  Thr Asp Phe 
        995                 1000                 1005             


Leu Pro  Lys Leu Leu Asp Cys  Ser Met Glu Ile Lys  Ser Phe His 
    1010                 1015                 1020             


Glu Pro  Pro Lys Leu Pro Ser  Tyr Ser Thr His Glu  Leu Cys Glu 
    1025                 1030                 1035             


Arg Phe  Ala Arg Ile Met Leu  Ser Leu Ser Arg Thr  Pro Ala Asp 
    1040                 1045                 1050             


Gly Arg  
    1055 


<210>  53
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53

Met Gly Ser Arg Asp His Leu Phe Lys Val Leu Val Val Gly Asp Ala 
1               5                   10                  15      


Ala Val Gly Lys Thr Ser Leu Val Gln Arg Tyr Ser Gln Asp Ser Phe 
            20                  25                  30          


Ser Lys His Tyr Lys Ser Thr Val Gly Val Asp Phe Ala Leu Lys Val 
        35                  40                  45              


Leu Gln Trp Ser Asp Tyr Glu Ile Val Arg Leu Gln Leu Trp Asp Ile 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Thr Ser Met Thr Arg Leu Tyr Tyr Arg Asp 
65                  70                  75                  80  


Ala Ser Ala Cys Val Ile Met Phe Asp Val Thr Asn Ala Thr Thr Phe 
                85                  90                  95      


Ser Asn Ser Gln Arg Trp Lys Gln Asp Leu Asp Ser Lys Leu Thr Leu 
            100                 105                 110         


Pro Asn Gly Glu Pro Val Pro Cys Leu Leu Leu Ala Asn Lys Cys Asp 
        115                 120                 125             


Leu Ser Pro Trp Ala Val Ser Arg Asp Gln Ile Asp Arg Phe Ser Lys 
    130                 135                 140                 


Glu Asn Gly Phe Thr Gly Trp Thr Glu Thr Ser Val Lys Glu Asn Lys 
145                 150                 155                 160 


Asn Ile Asn Glu Ala Met Arg Val Leu Ile Glu Lys Met Met Arg Asn 
                165                 170                 175     


Ser Thr Glu Asp Ile Met Ser Leu Ser Thr Gln Gly Asp Tyr Ile Asn 
            180                 185                 190         


Leu Gln Thr Lys Ser Ser Ser Trp Ser Cys Cys 
        195                 200             


<210>  54
<211>  1722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Met Ser Asp Pro Arg Gln Ser Gln Glu Glu Lys His Lys Leu Gly Arg 
1               5                   10                  15      


Ala Ser Ser Lys Phe Lys Asp Pro Pro Arg Ile Met Gln Ser Asp Asp 
            20                  25                  30          


Tyr Phe Ala Arg Lys Phe Lys Ala Ile Asn Gly Asn Met Gly Pro Thr 
        35                  40                  45              


Thr Ser Leu Asn Ala Ser Asn Ser Asn Glu Thr Gly Gly Gly Gly Pro 
    50                  55                  60                  


Ala Asn Gly Thr Pro Ala Val Pro Lys Met Gly Val Arg Ala Arg Val 
65                  70                  75                  80  


Ser Glu Trp Pro Pro Lys Lys Asp Cys Ser Lys Glu Leu Thr Cys Lys 
                85                  90                  95      


Ala Leu Trp Glu Ser Arg Ser Gln Thr Ser Tyr Glu Ser Ile Thr Ser 
            100                 105                 110         


Val Leu Gln Asn Gly Gln Ser Asp Gln Ser Glu Gly Gln Gln Asp Glu 
        115                 120                 125             


Gln Leu Asp Leu Asp Phe Val Glu Ala Lys Tyr Thr Ile Gly Asp Ile 
    130                 135                 140                 


Phe Val His Ser Pro Gln Arg Gly Leu His Pro Ile Arg Gln Arg Ser 
145                 150                 155                 160 


Asn Ser Asp Val Thr Ile Ser Asp Ile Asp Ala Glu Asp Val Leu Asp 
                165                 170                 175     


Gln Asn Ala Val Asn Pro Asn Thr Gly Ala Ala Leu His Arg Glu Tyr 
            180                 185                 190         


Gly Ser Thr Ser Ser Ile Asp Arg Gln Gly Leu Ser Gly Glu Asn Phe 
        195                 200                 205             


Phe Ala Met Leu Arg Gly Tyr Arg Val Glu Asn Tyr Asp His Lys Ala 
    210                 215                 220                 


Met Val Pro Phe Gly Phe Pro Glu Phe Phe Arg Cys Asp Pro Ala Ile 
225                 230                 235                 240 


Ser Pro Ser Leu His Ala Ala Ala Gln Ile Ser Arg Gly Glu Phe Val 
                245                 250                 255     


Arg Ile Ser Gly Leu Asp Tyr Val Asp Ser Ala Leu Leu Met Gly Arg 
            260                 265                 270         


Asp Arg Asp Lys Pro Phe Lys Arg Arg Leu Lys Ser Glu Ser Val Glu 
        275                 280                 285             


Thr Ser Leu Phe Arg Lys Leu Arg Thr Val Lys Ser Glu His Glu Thr 
    290                 295                 300                 


Phe Lys Phe Thr Ser Glu Leu Glu Glu Ser Arg Leu Glu Arg Gly Ile 
305                 310                 315                 320 


Arg Pro Trp Asn Cys Gln Arg Cys Phe Ala His Tyr Asp Val Gln Ser 
                325                 330                 335     


Ile Leu Phe Asn Ile Asn Glu Ala Met Ala Thr Arg Ala Asn Val Gly 
            340                 345                 350         


Lys Arg Lys Asn Ile Thr Thr Gly Ala Ser Ala Ala Ser Gln Thr Gln 
        355                 360                 365             


Met Pro Thr Gly Gln Thr Gly Asn Cys Glu Ser Pro Leu Gly Ser Lys 
    370                 375                 380                 


Glu Asp Leu Asn Ser Lys Glu Asn Leu Asp Ala Asp Glu Gly Asp Gly 
385                 390                 395                 400 


Lys Ser Asn Asp Leu Val Leu Ser Cys Pro Tyr Phe Arg Asn Glu Thr 
                405                 410                 415     


Gly Gly Glu Gly Asp Arg Arg Ile Ala Leu Ser Arg Ala Asn Ser Ser 
            420                 425                 430         


Ser Phe Ser Ser Gly Glu Ser Cys Ser Phe Glu Ser Ser Leu Ser Ser 
        435                 440                 445             


His Cys Thr Asn Ala Gly Val Ser Val Leu Glu Val Pro Arg Glu Asn 
    450                 455                 460                 


Gln Pro Ile His Arg Glu Lys Val Lys Arg Tyr Ile Ile Glu His Ile 
465                 470                 475                 480 


Asp Leu Gly Ala Tyr Tyr Tyr Arg Lys Phe Phe Tyr Gly Lys Glu His 
                485                 490                 495     


Gln Asn Tyr Phe Gly Ile Asp Glu Asn Leu Gly Pro Val Ala Val Ser 
            500                 505                 510         


Ile Arg Arg Glu Lys Val Glu Asp Ala Lys Glu Lys Glu Gly Ser Gln 
        515                 520                 525             


Phe Asn Tyr Arg Val Ala Phe Arg Thr Ser Glu Leu Thr Thr Leu Arg 
    530                 535                 540                 


Gly Ala Ile Leu Glu Asp Ala Ile Pro Ser Thr Ala Arg His Gly Thr 
545                 550                 555                 560 


Ala Arg Gly Leu Pro Leu Lys Glu Val Leu Glu Tyr Val Ile Pro Glu 
                565                 570                 575     


Leu Ser Ile Gln Cys Leu Arg Gln Ala Ser Asn Ser Pro Lys Val Ser 
            580                 585                 590         


Glu Gln Leu Leu Lys Leu Asp Glu Gln Gly Leu Ser Phe Gln His Lys 
        595                 600                 605             


Ile Gly Ile Leu Tyr Cys Lys Ala Gly Gln Ser Thr Glu Glu Glu Met 
    610                 615                 620                 


Tyr Asn Asn Glu Thr Ala Gly Pro Ala Phe Glu Glu Phe Leu Asp Leu 
625                 630                 635                 640 


Leu Gly Gln Arg Val Arg Leu Lys Gly Phe Ser Lys Tyr Arg Ala Gln 
                645                 650                 655     


Leu Asp Asn Lys Thr Asp Ser Thr Gly Thr His Ser Leu Tyr Thr Thr 
            660                 665                 670         


Tyr Lys Asp Tyr Glu Leu Met Phe His Val Ser Thr Leu Leu Pro Tyr 
        675                 680                 685             


Met Pro Asn Asn Arg Gln Gln Leu Leu Arg Lys Arg His Ile Gly Asn 
    690                 695                 700                 


Asp Ile Val Thr Ile Val Phe Gln Glu Pro Gly Ala Leu Pro Phe Thr 
705                 710                 715                 720 


Pro Lys Ser Ile Arg Ser His Phe Gln His Val Phe Val Ile Val Lys 
                725                 730                 735     


Val His Asn Pro Cys Thr Glu Asn Val Cys Tyr Ser Val Gly Val Ser 
            740                 745                 750         


Arg Ser Lys Asp Val Pro Pro Phe Gly Pro Pro Ile Pro Lys Gly Val 
        755                 760                 765             


Thr Phe Pro Lys Ser Ala Val Phe Arg Asp Phe Leu Leu Ala Lys Val 
    770                 775                 780                 


Ile Asn Ala Glu Asn Ala Ala His Lys Ser Glu Lys Phe Arg Ala Met 
785                 790                 795                 800 


Ala Thr Arg Thr Arg Gln Glu Tyr Leu Lys Asp Leu Ala Glu Asn Phe 
                805                 810                 815     


Val Thr Thr Ala Thr Val Asp Thr Ser Val Lys Phe Ser Phe Ile Thr 
            820                 825                 830         


Leu Gly Ala Lys Lys Lys Glu Lys Val Lys Pro Arg Lys Asp Ala His 
        835                 840                 845             


Leu Phe Ser Ile Gly Ala Ile Met Trp His Val Ile Ala Arg Asp Phe 
    850                 855                 860                 


Gly Gln Ser Ala Asp Ile Glu Cys Leu Leu Gly Ile Ser Asn Glu Phe 
865                 870                 875                 880 


Ile Met Leu Ile Glu Lys Asp Ser Lys Asn Val Val Phe Asn Cys Ser 
                885                 890                 895     


Cys Arg Asp Val Ile Gly Trp Thr Ser Gly Leu Val Ser Ile Lys Val 
            900                 905                 910         


Phe Tyr Glu Arg Gly Glu Cys Val Leu Leu Ser Ser Val Asp Asn Cys 
        915                 920                 925             


Ala Glu Asp Ile Arg Glu Ile Val Gln Arg Leu Val Ile Val Thr Arg 
    930                 935                 940                 


Gly Cys Glu Thr Val Glu Met Thr Leu Arg Arg Asn Gly Leu Gly Gln 
945                 950                 955                 960 


Leu Gly Phe His Val Asn Phe Glu Gly Ile Val Ala Asp Val Glu Pro 
                965                 970                 975     


Phe Gly Phe Ala Trp Lys Ala Gly Leu Arg Gln Gly Ser Arg Leu Val 
            980                 985                 990         


Glu Ile Cys Lys Val Ala Val Ala  Thr Leu Thr His Glu  Gln Met Ile 
        995                 1000                 1005             


Asp Leu  Leu Arg Thr Ser Val  Thr Val Lys Val Val  Ile Ile Gln 
    1010                 1015                 1020             


Pro His  Asp Asp Gly Ser Pro  Arg Arg Gly Cys Ser  Glu Leu Cys 
    1025                 1030                 1035             


Arg Ile  Pro Met Val Glu Tyr  Lys Leu Asp Ser Glu  Gly Thr Pro 
    1040                 1045                 1050             


Cys Glu  Tyr Lys Thr Pro Phe  Arg Arg Asn Thr Thr  Trp His Arg 
    1055                 1060                 1065             


Val Pro  Thr Pro Ala Leu Gln  Pro Leu Ser Arg Ala  Ser Pro Ile 
    1070                 1075                 1080             


Pro Gly  Thr Pro Asp Arg Leu  Pro Cys Gln Gln Leu  Leu Gln Gln 
    1085                 1090                 1095             


Ala Gln  Ala Ala Ile Pro Arg  Ser Thr Ser Phe Asp  Arg Lys Leu 
    1100                 1105                 1110             


Pro Asp  Gly Thr Arg Ser Ser  Pro Ser Asn Gln Ser  Ser Ser Ser 
    1115                 1120                 1125             


Asp Pro  Gly Pro Gly Gly Ser  Gly Pro Trp Arg Pro  Gln Val Gly 
    1130                 1135                 1140             


Tyr Asp  Gly Cys Gln Ser Pro  Leu Leu Leu Glu His  Gln Gly Ser 
    1145                 1150                 1155             


Gly Pro  Leu Glu Cys Asp Gly  Ala Arg Glu Arg Glu  Asp Thr Met 
    1160                 1165                 1170             


Glu Ala  Ser Arg His Pro Glu  Thr Lys Trp His Gly  Pro Pro Ser 
    1175                 1180                 1185             


Lys Val  Leu Gly Ser Tyr Lys  Glu Arg Ala Leu Gln  Lys Asp Gly 
    1190                 1195                 1200             


Ser Cys  Lys Asp Ser Pro Asn  Lys Leu Ser His Ile  Gly Asp Lys 
    1205                 1210                 1215             


Ser Cys  Ser Ser His Ser Ser  Ser Asn Thr Leu Ser  Ser Asn Thr 
    1220                 1225                 1230             


Ser Ser  Asn Ser Asp Asp Lys  His Phe Gly Ser Gly  Asp Leu Met 
    1235                 1240                 1245             


Asp Pro  Glu Leu Leu Gly Leu  Thr Tyr Ile Lys Gly  Ala Ser Thr 
    1250                 1255                 1260             


Asp Ser  Gly Ile Asp Thr Ala  Pro Cys Met Pro Ala  Thr Ile Leu 
    1265                 1270                 1275             


Gly Pro  Val His Leu Ala Gly  Ser Arg Ser Leu Ile  His Ser Arg 
    1280                 1285                 1290             


Ala Glu  Gln Trp Ala Asp Ala  Ala Asp Val Ser Gly  Pro Asp Asp 
    1295                 1300                 1305             


Glu Pro  Ala Lys Leu Tyr Ser  Val His Gly Tyr Ala  Ser Thr Ile 
    1310                 1315                 1320             


Ser Ala  Gly Ser Ala Ala Glu  Gly Ser Met Gly Asp  Leu Ser Glu 
    1325                 1330                 1335             


Ile Ser  Ser His Ser Ser Gly  Ser His His Ser Gly  Ser Pro Ser 
    1340                 1345                 1350             


Ala His  Cys Ser Lys Ser Ser  Gly Ser Leu Asp Ser  Ser Lys Val 
    1355                 1360                 1365             


Tyr Ile  Val Ser His Ser Ser  Gly Gln Gln Val Pro  Gly Ser Met 
    1370                 1375                 1380             


Ser Lys  Pro Tyr His Arg Gln  Gly Ala Val Asn Lys  Tyr Val Ile 
    1385                 1390                 1395             


Gly Trp  Lys Lys Ser Glu Gly  Ser Pro Pro Pro Glu  Glu Pro Glu 
    1400                 1405                 1410             


Val Thr  Glu Cys Pro Gly Met  Tyr Ser Glu Met Asp  Val Met Ser 
    1415                 1420                 1425             


Thr Ala  Thr Gln His Gln Thr  Val Val Gly Asp Ala  Val Ala Glu 
    1430                 1435                 1440             


Thr Gln  His Val Leu Ser Lys  Glu Asp Phe Leu Lys  Leu Met Leu 
    1445                 1450                 1455             


Pro Asp  Ser Pro Leu Val Glu  Glu Gly Arg Arg Lys  Phe Ser Phe 
    1460                 1465                 1470             


Tyr Gly  Asn Leu Ser Pro Arg  Arg Ser Leu Tyr Arg  Thr Leu Ser 
    1475                 1480                 1485             


Asp Glu  Ser Ile Cys Ser Asn  Arg Arg Gly Ser Ser  Phe Gly Ser 
    1490                 1495                 1500             


Ser Arg  Ser Ser Val Leu Asp  Gln Ala Leu Pro Asn  Asp Ile Leu 
    1505                 1510                 1515             


Phe Ser  Thr Thr Pro Pro Tyr  His Ser Thr Leu Pro  Pro Arg Ala 
    1520                 1525                 1530             


His Pro  Ala Pro Ser Met Gly  Ser Leu Arg Asn Glu  Phe Trp Phe 
    1535                 1540                 1545             


Ser Asp  Gly Ser Leu Ser Asp  Lys Ser Lys Cys Ala  Asp Pro Gly 
    1550                 1555                 1560             


Leu Met  Pro Leu Pro Asp Thr  Ala Thr Gly Leu Asp  Trp Thr His 
    1565                 1570                 1575             


Leu Val  Asp Ala Ala Arg Ala  Phe Glu Gly Leu Asp  Ser Asp Glu 
    1580                 1585                 1590             


Glu Leu  Gly Leu Leu Cys His  His Thr Ser Tyr Leu  Asp Gln Arg 
    1595                 1600                 1605             


Val Ala  Ser Phe Cys Thr Leu  Thr Asp Met Gln His  Gly Gln Asp 
    1610                 1615                 1620             


Leu Glu  Gly Ala Gln Glu Leu  Pro Leu Cys Val Asp  Pro Gly Ser 
    1625                 1630                 1635             


Gly Lys  Glu Phe Met Asp Thr  Thr Gly Glu Arg Ser  Pro Ser Pro 
    1640                 1645                 1650             


Leu Thr  Gly Lys Val Asn Gln  Leu Glu Leu Ile Leu  Arg Gln Leu 
    1655                 1660                 1665             


Gln Thr  Asp Leu Arg Lys Glu  Lys Gln Asp Lys Ala  Val Leu Gln 
    1670                 1675                 1680             


Ala Glu  Val Gln His Leu Arg  Gln Asp Asn Met Arg  Leu Gln Glu 
    1685                 1690                 1695             


Glu Ser  Gln Thr Ala Thr Ala  Gln Leu Arg Lys Phe  Thr Glu Trp 
    1700                 1705                 1710             


Phe Phe  Thr Thr Ile Asp Lys  Lys Ser 
    1715                 1720         


<210>  55
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55

Met Ala Ala Ala Ser Ala Val Ser Val Leu Leu Val Ala Ala Glu Arg 
1               5                   10                  15      


Asn Arg Trp His Arg Leu Pro Ser Leu Leu Leu Pro Pro Arg Thr Trp 
            20                  25                  30          


Val Trp Arg Gln Arg Thr Met Lys Tyr Thr Thr Ala Thr Gly Arg Asn 
        35                  40                  45              


Ile Thr Lys Val Leu Ile Ala Asn Arg Gly Glu Ile Ala Cys Arg Val 
    50                  55                  60                  


Met Arg Thr Ala Lys Lys Leu Gly Val Gln Thr Val Ala Val Tyr Ser 
65                  70                  75                  80  


Glu Ala Asp Arg Asn Ser Met His Val Asp Met Ala Asp Glu Ala Tyr 
                85                  90                  95      


Ser Ile Gly Pro Ala Pro Ser Gln Gln Ser Tyr Leu Ser Met Glu Lys 
            100                 105                 110         


Ile Ile Gln Val Ala Lys Thr Ser Ala Ala Gln Ala Ile His Pro Gly 
        115                 120                 125             


Cys Gly Phe Leu Ser Glu Asn Met Glu Phe Ala Glu Leu Cys Lys Gln 
    130                 135                 140                 


Glu Gly Ile Ile Phe Ile Gly Pro Pro Pro Ser Ala Ile Arg Asp Met 
145                 150                 155                 160 


Gly Ile Lys Ser Thr Ser Lys Ser Ile Met Ala Ala Ala Gly Val Pro 
                165                 170                 175     


Val Val Glu Gly Tyr His Gly Glu Asp Gln Ser Asp Gln Cys Leu Lys 
            180                 185                 190         


Glu His Ala Arg Arg Ile Gly Tyr Pro Val Met Ile Lys Ala Val Arg 
        195                 200                 205             


Gly Gly Gly Gly Lys Gly Met Arg Ile Val Arg Ser Glu Gln Glu Phe 
    210                 215                 220                 


Gln Glu Gln Leu Glu Ser Ala Arg Arg Glu Ala Lys Lys Ser Phe Asn 
225                 230                 235                 240 


Asp Asp Ala Met Leu Ile Glu Lys Phe Val Asp Thr Pro Arg His Val 
                245                 250                 255     


Glu Val Gln Val Phe Gly Asp His His Gly Asn Ala Val Tyr Leu Phe 
            260                 265                 270         


Glu Arg Asp Cys Ser Val Gln Arg Arg His Gln Lys Ile Ile Glu Glu 
        275                 280                 285             


Ala Pro Ala Pro Gly Ile Lys Ser Glu Val Arg Lys Lys Leu Gly Glu 
    290                 295                 300                 


Ala Ala Val Arg Ala Ala Lys Ala Val Asn Tyr Val Gly Ala Gly Thr 
305                 310                 315                 320 


Val Glu Phe Ile Met Asp Ser Lys His Asn Phe Cys Phe Met Glu Met 
                325                 330                 335     


Asn Thr Arg Leu Gln Val Glu His Pro Val Thr Glu Met Ile Thr Gly 
            340                 345                 350         


Thr Asp Leu Val Glu Trp Gln Leu Arg Ile Ala Ala Gly Glu Lys Ile 
        355                 360                 365             


Pro Leu Ser Gln Glu Glu Ile Thr Leu Gln Gly His Ala Phe Glu Ala 
    370                 375                 380                 


Arg Ile Tyr Ala Glu Asp Pro Ser Asn Asn Phe Met Pro Val Ala Gly 
385                 390                 395                 400 


Pro Leu Val His Leu Ser Thr Pro Arg Ala Asp Pro Ser Thr Arg Ile 
                405                 410                 415     


Glu Thr Gly Val Arg Gln Gly Asp Glu Val Ser Val His Tyr Asp Pro 
            420                 425                 430         


Met Ile Ala Lys Leu Val Val Trp Ala Ala Asp Arg Gln Ala Ala Leu 
        435                 440                 445             


Thr Lys Leu Arg Tyr Ser Leu Arg Gln Tyr Asn Ile Val Gly Leu His 
    450                 455                 460                 


Thr Asn Ile Asp Phe Leu Leu Asn Leu Ser Gly His Pro Glu Phe Glu 
465                 470                 475                 480 


Ala Gly Asn Val His Thr Asp Phe Ile Pro Gln His His Lys Gln Leu 
                485                 490                 495     


Leu Leu Ser Arg Lys Ala Ala Ala Lys Glu Ser Leu Cys Gln Ala Ala 
            500                 505                 510         


Leu Gly Leu Ile Leu Lys Glu Lys Ala Met Thr Asp Thr Phe Thr Leu 
        515                 520                 525             


Gln Ala His Asp Gln Phe Ser Pro Phe Ser Ser Ser Ser Gly Arg Arg 
    530                 535                 540                 


Leu Asn Ile Ser Tyr Thr Arg Asn Met Thr Leu Lys Asp Gly Lys Asn 
545                 550                 555                 560 


Asn Val Ala Ile Ala Val Thr Tyr Asn His Asp Gly Ser Tyr Ser Met 
                565                 570                 575     


Gln Ile Glu Asp Lys Thr Phe Gln Val Leu Gly Asn Leu Tyr Ser Glu 
            580                 585                 590         


Gly Asp Cys Thr Tyr Leu Lys Cys Ser Val Asn Gly Val Ala Ser Lys 
        595                 600                 605             


Ala Lys Leu Ile Ile Leu Glu Asn Thr Ile Tyr Leu Phe Ser Lys Glu 
    610                 615                 620                 


Gly Ser Ile Glu Ile Asp Ile Pro Val Pro Lys Tyr Leu Ser Ser Val 
625                 630                 635                 640 


Ser Ser Gln Glu Thr Gln Gly Gly Pro Leu Ala Pro Met Thr Gly Thr 
                645                 650                 655     


Ile Glu Lys Val Phe Val Lys Ala Gly Asp Lys Val Lys Ala Gly Asp 
            660                 665                 670         


Ser Leu Met Val Met Ile Ala Met Lys Met Glu His Thr Ile Lys Ser 
        675                 680                 685             


Pro Lys Asp Gly Thr Val Lys Lys Val Phe Tyr Arg Glu Gly Ala Gln 
    690                 695                 700                 


Ala Asn Arg His Thr Pro Leu Val Glu Phe Glu Glu Glu Glu Ser Asp 
705                 710                 715                 720 


Lys Arg Glu Ser Glu 
                725 


<210>  56
<211>  1573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Met Ala Phe Ser Lys Gly Phe Arg Ile Tyr His Lys Leu Asp Pro Pro 
1               5                   10                  15      


Pro Phe Ser Leu Ile Val Glu Thr Arg His Lys Glu Glu Cys Leu Met 
            20                  25                  30          


Phe Glu Ser Gly Ala Val Ala Val Leu Ser Ser Ala Glu Lys Glu Ala 
        35                  40                  45              


Ile Lys Gly Thr Tyr Ser Lys Val Leu Asp Ala Tyr Gly Leu Leu Gly 
    50                  55                  60                  


Val Leu Arg Leu Asn Leu Gly Asp Thr Met Leu His Tyr Leu Val Leu 
65                  70                  75                  80  


Val Thr Gly Cys Met Ser Val Gly Lys Ile Gln Glu Ser Glu Val Phe 
                85                  90                  95      


Arg Val Thr Ser Thr Glu Phe Ile Ser Leu Arg Ile Asp Ser Ser Asp 
            100                 105                 110         


Glu Asp Arg Ile Ser Glu Val Arg Lys Val Leu Asn Ser Gly Asn Phe 
        115                 120                 125             


Tyr Phe Ala Trp Ser Ala Ser Gly Ile Ser Leu Asp Leu Ser Leu Asn 
    130                 135                 140                 


Ala His Arg Ser Met Gln Glu Gln Thr Thr Asp Asn Arg Phe Phe Trp 
145                 150                 155                 160 


Asn Gln Ser Leu His Leu His Leu Lys His Tyr Gly Val Asn Cys Asp 
                165                 170                 175     


Asp Trp Leu Leu Arg Leu Met Cys Gly Gly Val Glu Ile Arg Thr Ile 
            180                 185                 190         


Tyr Ala Ala His Lys Gln Ala Lys Ala Cys Leu Ile Ser Arg Leu Ser 
        195                 200                 205             


Cys Glu Arg Ala Gly Thr Arg Phe Asn Val Arg Gly Thr Asn Asp Asp 
    210                 215                 220                 


Gly His Val Ala Asn Phe Val Glu Thr Glu Gln Val Val Tyr Leu Asp 
225                 230                 235                 240 


Asp Ser Val Ser Ser Phe Ile Gln Ile Arg Gly Ser Val Pro Leu Phe 
                245                 250                 255     


Trp Glu Gln Pro Gly Leu Gln Val Gly Ser His Arg Val Arg Met Ser 
            260                 265                 270         


Arg Gly Phe Glu Ala Asn Ala Pro Ala Phe Asp Arg His Phe Arg Thr 
        275                 280                 285             


Leu Lys Asn Leu Tyr Gly Lys Gln Ile Ile Val Asn Leu Leu Gly Ser 
    290                 295                 300                 


Lys Glu Gly Glu His Met Leu Ser Lys Ala Phe Gln Ser His Leu Lys 
305                 310                 315                 320 


Ala Ser Glu His Ala Ala Asp Ile Gln Met Val Asn Phe Asp Tyr His 
                325                 330                 335     


Gln Met Val Lys Gly Gly Lys Ala Glu Lys Leu His Ser Val Leu Lys 
            340                 345                 350         


Pro Gln Val Gln Lys Phe Leu Asp Tyr Gly Phe Phe Tyr Phe Asn Gly 
        355                 360                 365             


Ser Glu Val Gln Arg Cys Gln Ser Gly Thr Val Arg Thr Asn Cys Leu 
    370                 375                 380                 


Asp Cys Leu Asp Arg Thr Asn Ser Val Gln Ala Phe Leu Gly Leu Glu 
385                 390                 395                 400 


Met Leu Ala Lys Gln Leu Glu Ala Leu Gly Leu Ala Glu Lys Pro Gln 
                405                 410                 415     


Leu Val Thr Arg Phe Gln Glu Val Phe Arg Ser Met Trp Ser Val Asn 
            420                 425                 430         


Gly Asp Ser Ile Ser Lys Ile Tyr Ala Gly Thr Gly Ala Leu Glu Gly 
        435                 440                 445             


Lys Ala Lys Leu Lys Asp Gly Ala Arg Ser Val Thr Arg Thr Ile Gln 
    450                 455                 460                 


Asn Asn Phe Phe Asp Ser Ser Lys Gln Glu Ala Ile Asp Val Leu Leu 
465                 470                 475                 480 


Leu Gly Asn Thr Leu Asn Ser Asp Leu Ala Asp Lys Ala Arg Ala Leu 
                485                 490                 495     


Leu Thr Thr Gly Ser Leu Arg Val Ser Glu Gln Thr Leu Gln Ser Ala 
            500                 505                 510         


Ser Ser Lys Val Leu Lys Ser Met Cys Glu Asn Phe Tyr Lys Tyr Ser 
        515                 520                 525             


Lys Pro Lys Lys Ile Arg Val Cys Val Gly Thr Trp Asn Val Asn Gly 
    530                 535                 540                 


Gly Lys Gln Phe Arg Ser Ile Ala Phe Lys Asn Gln Thr Leu Thr Asp 
545                 550                 555                 560 


Trp Leu Leu Asp Ala Pro Lys Leu Ala Gly Ile Gln Glu Phe Gln Asp 
                565                 570                 575     


Lys Arg Ser Lys Pro Thr Asp Ile Phe Ala Ile Gly Phe Glu Glu Met 
            580                 585                 590         


Val Glu Leu Asn Ala Gly Asn Ile Val Ser Ala Ser Thr Thr Asn Gln 
        595                 600                 605             


Lys Leu Trp Ala Val Glu Leu Gln Lys Thr Ile Ser Arg Asp Asn Lys 
    610                 615                 620                 


Tyr Val Leu Leu Ala Ser Glu Gln Leu Val Gly Val Cys Leu Phe Val 
625                 630                 635                 640 


Phe Ile Arg Pro Gln His Ala Pro Phe Ile Arg Asp Val Ala Val Asp 
                645                 650                 655     


Thr Val Lys Thr Gly Met Gly Gly Ala Thr Gly Asn Lys Gly Ala Val 
            660                 665                 670         


Ala Ile Arg Met Leu Phe His Thr Thr Ser Leu Cys Phe Val Cys Ser 
        675                 680                 685             


His Phe Ala Ala Gly Gln Ser Gln Val Lys Glu Arg Asn Glu Asp Phe 
    690                 695                 700                 


Ile Glu Ile Ala Arg Lys Leu Ser Phe Pro Met Gly Arg Met Leu Phe 
705                 710                 715                 720 


Ser His Asp Tyr Val Phe Trp Cys Gly Asp Phe Asn Tyr Arg Ile Asp 
                725                 730                 735     


Leu Pro Asn Glu Glu Val Lys Glu Leu Ile Arg Gln Gln Asn Trp Asp 
            740                 745                 750         


Ser Leu Ile Ala Gly Asp Gln Leu Ile Asn Gln Lys Asn Ala Gly Gln 
        755                 760                 765             


Val Phe Arg Gly Phe Leu Glu Gly Lys Val Thr Phe Ala Pro Thr Tyr 
    770                 775                 780                 


Lys Tyr Asp Leu Phe Ser Asp Asp Tyr Asp Thr Ser Glu Lys Cys Arg 
785                 790                 795                 800 


Thr Pro Ala Trp Thr Asp Arg Val Leu Trp Arg Arg Arg Lys Trp Pro 
                805                 810                 815     


Phe Asp Arg Ser Ala Glu Asp Leu Asp Leu Leu Asn Ala Ser Phe Gln 
            820                 825                 830         


Asp Glu Ser Lys Ile Leu Tyr Thr Trp Thr Pro Gly Thr Leu Leu His 
        835                 840                 845             


Tyr Gly Arg Ala Glu Leu Lys Thr Ser Asp His Arg Pro Val Val Ala 
    850                 855                 860                 


Leu Ile Asp Ile Asp Ile Phe Glu Val Glu Ala Glu Glu Arg Gln Asn 
865                 870                 875                 880 


Ile Tyr Lys Glu Val Ile Ala Val Gln Gly Pro Pro Asp Gly Thr Val 
                885                 890                 895     


Leu Val Ser Ile Lys Ser Ser Leu Pro Glu Asn Asn Phe Phe Asp Asp 
            900                 905                 910         


Ala Leu Ile Asp Glu Leu Leu Gln Gln Phe Ala Ser Phe Gly Glu Val 
        915                 920                 925             


Ile Leu Ile Arg Phe Val Glu Asp Lys Met Trp Val Thr Phe Leu Glu 
    930                 935                 940                 


Gly Ser Ser Ala Leu Asn Val Leu Ser Leu Asn Gly Lys Glu Leu Leu 
945                 950                 955                 960 


Asn Arg Thr Ile Thr Ile Ala Leu Lys Ser Pro Asp Trp Ile Lys Asn 
                965                 970                 975     


Leu Glu Glu Glu Met Ser Leu Glu Lys Ile Ser Ile Ala Leu Pro Ser 
            980                 985                 990         


Ser Thr Ser Ser Thr Leu Leu Gly  Glu Asp Ala Glu Val  Ala Ala Asp 
        995                 1000                 1005             


Phe Asp  Met Glu Gly Asp Val  Asp Asp Tyr Ser Ala  Glu Val Glu 
    1010                 1015                 1020             


Glu Leu  Leu Pro Gln His Leu  Gln Pro Ser Ser Ser  Ser Gly Leu 
    1025                 1030                 1035             


Gly Thr  Ser Pro Ser Ser Ser  Pro Arg Thr Ser Pro  Cys Gln Ser 
    1040                 1045                 1050             


Pro Thr  Ile Ser Glu Gly Pro  Val Pro Ser Leu Pro  Ile Arg Pro 
    1055                 1060                 1065             


Ser Arg  Ala Pro Ser Arg Thr  Pro Gly Pro Pro Ser  Ala Gln Ser 
    1070                 1075                 1080             


Ser Pro  Ile Asp Ala Gln Pro  Ala Thr Pro Leu Pro  Gln Lys Asp 
    1085                 1090                 1095             


Pro Ala  Gln Pro Leu Glu Pro  Lys Arg Pro Pro Pro  Pro Arg Pro 
    1100                 1105                 1110             


Val Ala  Pro Pro Thr Arg Pro  Ala Pro Pro Gln Arg  Pro Pro Pro 
    1115                 1120                 1125             


Pro Ser  Gly Ala Arg Ser Pro  Ala Pro Thr Arg Lys  Glu Phe Gly 
    1130                 1135                 1140             


Gly Ile  Gly Ala Pro Pro Ser  Pro Gly Val Ala Arg  Arg Glu Met 
    1145                 1150                 1155             


Glu Ala  Pro Lys Ser Pro Gly  Thr Thr Arg Lys Asp  Asn Ile Gly 
    1160                 1165                 1170             


Arg Ser  Gln Pro Ser Pro Gln  Ala Gly Leu Ala Gly  Pro Gly Pro 
    1175                 1180                 1185             


Ala Gly  Tyr Ser Thr Ala Arg  Pro Thr Ile Pro Pro  Arg Ala Gly 
    1190                 1195                 1200             


Val Ile  Ser Ala Pro Gln Ser  His Ala Arg Ala Ser  Ala Gly Arg 
    1205                 1210                 1215             


Leu Thr  Pro Glu Ser Gln Ser  Lys Thr Ser Glu Thr  Ser Lys Gly 
    1220                 1225                 1230             


Ser Thr  Phe Leu Pro Glu Pro  Leu Lys Pro Gln Ala  Ala Phe Pro 
    1235                 1240                 1245             


Pro Gln  Ser Ser Leu Pro Pro  Pro Ala Gln Arg Leu  Gln Glu Pro 
    1250                 1255                 1260             


Leu Val  Pro Val Ala Ala Pro  Met Pro Gln Ser Gly  Pro Gln Pro 
    1265                 1270                 1275             


Asn Leu  Glu Thr Pro Pro Gln  Pro Pro Pro Arg Ser  Arg Ser Ser 
    1280                 1285                 1290             


His Ser  Leu Pro Ser Glu Ala  Ser Ser Gln Pro Gln  Val Lys Thr 
    1295                 1300                 1305             


Asn Gly  Ile Ser Asp Gly Lys  Arg Glu Ser Pro Leu  Lys Ile Asp 
    1310                 1315                 1320             


Pro Phe  Glu Asp Leu Ser Phe  Asn Leu Leu Ala Val  Ser Lys Ala 
    1325                 1330                 1335             


Gln Leu  Ser Val Gln Thr Ser  Pro Val Pro Thr Pro  Asp Pro Lys 
    1340                 1345                 1350             


Arg Leu  Ile Gln Leu Pro Ser  Ala Thr Gln Ser Asn  Val Leu Ser 
    1355                 1360                 1365             


Ser Val  Ser Cys Met Pro Thr  Met Pro Pro Ile Pro  Ala Arg Ser 
    1370                 1375                 1380             


Gln Ser  Gln Glu Asn Met Arg  Ser Ser Pro Asn Pro  Phe Ile Thr 
    1385                 1390                 1395             


Gly Leu  Thr Arg Thr Asn Pro  Phe Ser Asp Arg Thr  Ala Ala Pro 
    1400                 1405                 1410             


Gly Asn  Pro Phe Arg Ala Lys  Ser Glu Glu Ser Glu  Ala Thr Ser 
    1415                 1420                 1425             


Trp Phe  Ser Lys Glu Glu Pro  Val Thr Ile Ser Pro  Phe Pro Ser 
    1430                 1435                 1440             


Leu Gln  Pro Leu Gly His Asn  Lys Ser Arg Ala Ser  Ser Ser Leu 
    1445                 1450                 1455             


Asp Gly  Phe Lys Asp Ser Phe  Asp Leu Gln Gly Gln  Ser Thr Leu 
    1460                 1465                 1470             


Lys Ile  Ser Asn Pro Lys Gly  Trp Val Thr Phe Glu  Glu Glu Glu 
    1475                 1480                 1485             


Asp Phe  Gly Val Lys Gly Lys  Ser Lys Ser Ala Cys  Ser Asp Leu 
    1490                 1495                 1500             


Leu Gly  Asn Gln Pro Ser Ser  Phe Ser Gly Ser Asn  Leu Thr Leu 
    1505                 1510                 1515             


Asn Asp  Asp Trp Asn Lys Gly  Thr Asn Val Ser Phe  Cys Val Leu 
    1520                 1525                 1530             


Pro Ser  Arg Arg Pro Pro Pro  Pro Pro Val Pro Leu  Leu Pro Pro 
    1535                 1540                 1545             


Gly Thr  Ser Pro Pro Val Asp  Pro Phe Thr Thr Leu  Ala Ser Lys 
    1550                 1555                 1560             


Ala Ser  Pro Thr Leu Asp Phe  Thr Glu Arg 
    1565                 1570             


<210>  57
<211>  2527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57

Met Ala Ser Gly Ser Cys Gln Gly Cys Glu Glu Asp Glu Glu Thr Leu 
1               5                   10                  15      


Lys Lys Leu Ile Val Arg Leu Asn Asn Val Gln Glu Gly Lys Gln Ile 
            20                  25                  30          


Glu Thr Leu Val Gln Ile Leu Glu Asp Leu Leu Val Phe Thr Tyr Ser 
        35                  40                  45              


Glu Arg Ala Ser Lys Leu Phe Gln Gly Lys Asn Ile His Val Pro Leu 
    50                  55                  60                  


Leu Ile Val Leu Asp Ser Tyr Met Arg Val Ala Ser Val Gln Gln Val 
65                  70                  75                  80  


Gly Trp Ser Leu Leu Cys Lys Leu Ile Glu Val Cys Pro Gly Thr Met 
                85                  90                  95      


Gln Ser Leu Met Gly Pro Gln Asp Val Gly Asn Asp Trp Glu Val Leu 
            100                 105                 110         


Gly Val His Gln Leu Ile Leu Lys Met Leu Thr Val His Asn Ala Ser 
        115                 120                 125             


Val Asn Leu Ser Val Ile Gly Leu Lys Thr Leu Asp Leu Leu Leu Thr 
    130                 135                 140                 


Ser Gly Lys Ile Thr Leu Leu Ile Leu Asp Glu Glu Ser Asp Ile Phe 
145                 150                 155                 160 


Met Leu Ile Phe Asp Ala Met His Ser Phe Pro Ala Asn Asp Glu Val 
                165                 170                 175     


Gln Lys Leu Gly Cys Lys Ala Leu His Val Leu Phe Glu Arg Val Ser 
            180                 185                 190         


Glu Glu Gln Leu Thr Glu Phe Val Glu Asn Lys Asp Tyr Met Ile Leu 
        195                 200                 205             


Leu Ser Ala Leu Thr Asn Phe Lys Asp Glu Glu Glu Ile Val Leu His 
    210                 215                 220                 


Val Leu His Cys Leu His Ser Leu Ala Ile Pro Cys Asn Asn Val Glu 
225                 230                 235                 240 


Val Leu Met Ser Gly Asn Val Arg Cys Tyr Asn Ile Val Val Glu Ala 
                245                 250                 255     


Met Lys Ala Phe Pro Met Ser Glu Arg Ile Gln Glu Val Ser Cys Cys 
            260                 265                 270         


Leu Leu His Arg Leu Thr Leu Gly Asn Phe Phe Asn Ile Leu Val Leu 
        275                 280                 285             


Asn Glu Val His Glu Phe Val Val Lys Ala Val Gln Gln Tyr Pro Glu 
    290                 295                 300                 


Asn Ala Ala Leu Gln Ile Ser Ala Leu Ser Cys Leu Ala Leu Leu Thr 
305                 310                 315                 320 


Glu Thr Ile Phe Leu Asn Gln Asp Leu Glu Glu Lys Asn Glu Asn Gln 
                325                 330                 335     


Glu Asn Asp Asp Glu Gly Glu Glu Asp Lys Leu Phe Trp Leu Glu Ala 
            340                 345                 350         


Cys Tyr Lys Ala Leu Thr Trp His Arg Lys Asn Lys His Val Gln Glu 
        355                 360                 365             


Ala Ala Cys Trp Ala Leu Asn Asn Leu Leu Met Tyr Gln Asn Ser Leu 
    370                 375                 380                 


His Glu Lys Ile Gly Asp Glu Asp Gly His Phe Pro Ala His Arg Glu 
385                 390                 395                 400 


Val Met Leu Ser Met Leu Met His Ser Ser Ser Lys Glu Val Phe Gln 
                405                 410                 415     


Ala Ser Ala Asn Ala Leu Ser Thr Leu Leu Glu Gln Asn Val Asn Phe 
            420                 425                 430         


Arg Lys Ile Leu Leu Ser Lys Gly Ile His Leu Asn Val Leu Glu Leu 
        435                 440                 445             


Met Gln Lys His Ile His Ser Pro Glu Val Ala Glu Ser Gly Cys Lys 
    450                 455                 460                 


Met Leu Asn His Leu Phe Glu Gly Ser Asn Thr Ser Leu Asp Ile Met 
465                 470                 475                 480 


Ala Ala Val Val Pro Lys Ile Leu Thr Val Met Lys Arg His Glu Thr 
                485                 490                 495     


Ser Leu Pro Val Gln Leu Glu Ala Leu Arg Ala Ile Leu His Phe Ile 
            500                 505                 510         


Val Pro Gly Met Pro Glu Glu Ser Arg Glu Asp Thr Glu Phe His His 
        515                 520                 525             


Lys Leu Asn Met Val Lys Lys Gln Cys Phe Lys Asn Asp Ile His Lys 
    530                 535                 540                 


Leu Val Leu Ala Ala Leu Asn Arg Phe Ile Gly Asn Pro Gly Ile Gln 
545                 550                 555                 560 


Lys Cys Gly Leu Lys Val Ile Ser Ser Ile Val His Phe Pro Asp Ala 
                565                 570                 575     


Leu Glu Met Leu Ser Leu Glu Gly Ala Met Asp Ser Val Leu His Thr 
            580                 585                 590         


Leu Gln Met Tyr Pro Asp Asp Gln Glu Ile Gln Cys Leu Gly Leu Ser 
        595                 600                 605             


Leu Ile Gly Tyr Leu Ile Thr Lys Lys Asn Val Phe Ile Gly Thr Gly 
    610                 615                 620                 


His Leu Leu Ala Lys Ile Leu Val Ser Ser Leu Tyr Arg Phe Lys Asp 
625                 630                 635                 640 


Val Ala Glu Ile Gln Thr Lys Gly Phe Gln Thr Ile Leu Ala Ile Leu 
                645                 650                 655     


Lys Leu Ser Ala Ser Phe Ser Lys Leu Leu Val His His Ser Phe Asp 
            660                 665                 670         


Leu Val Ile Phe His Gln Met Ser Ser Asn Ile Met Glu Gln Lys Asp 
        675                 680                 685             


Gln Gln Phe Leu Asn Leu Cys Cys Lys Cys Phe Ala Lys Val Ala Met 
    690                 695                 700                 


Asp Asp Tyr Leu Lys Asn Val Met Leu Glu Arg Ala Cys Asp Gln Asn 
705                 710                 715                 720 


Asn Ser Ile Met Val Glu Cys Leu Leu Leu Leu Gly Ala Asp Ala Asn 
                725                 730                 735     


Gln Ala Lys Glu Gly Ser Ser Leu Ile Cys Gln Val Cys Glu Lys Glu 
            740                 745                 750         


Ser Ser Pro Lys Leu Val Glu Leu Leu Leu Asn Ser Gly Ser Arg Glu 
        755                 760                 765             


Gln Asp Val Arg Lys Ala Leu Thr Ile Ser Ile Gly Lys Gly Asp Ser 
    770                 775                 780                 


Gln Ile Ile Ser Leu Leu Leu Arg Arg Leu Ala Leu Asp Val Ala Asn 
785                 790                 795                 800 


Asn Ser Ile Cys Leu Gly Gly Phe Cys Ile Gly Lys Val Glu Pro Ser 
                805                 810                 815     


Trp Leu Gly Pro Leu Phe Pro Asp Lys Thr Ser Asn Leu Arg Lys Gln 
            820                 825                 830         


Thr Asn Ile Ala Ser Thr Leu Ala Arg Met Val Ile Arg Tyr Gln Met 
        835                 840                 845             


Lys Ser Ala Val Glu Glu Gly Thr Ala Ser Gly Ser Asp Gly Asn Phe 
    850                 855                 860                 


Ser Glu Asp Val Leu Ser Lys Phe Asp Glu Trp Thr Phe Ile Pro Asp 
865                 870                 875                 880 


Ser Ser Met Asp Ser Val Phe Ala Gln Ser Asp Asp Leu Asp Ser Glu 
                885                 890                 895     


Gly Ser Glu Gly Ser Phe Leu Val Lys Lys Lys Ser Asn Ser Ile Ser 
            900                 905                 910         


Val Gly Glu Phe Tyr Arg Asp Ala Val Leu Gln Arg Cys Ser Pro Asn 
        915                 920                 925             


Leu Gln Arg His Ser Asn Ser Leu Gly Pro Ile Phe Asp His Glu Asp 
    930                 935                 940                 


Leu Leu Lys Arg Lys Arg Lys Ile Leu Ser Ser Asp Asp Ser Leu Arg 
945                 950                 955                 960 


Ser Ser Lys Leu Gln Ser His Met Arg His Ser Asp Ser Ile Ser Ser 
                965                 970                 975     


Leu Ala Ser Glu Arg Glu Tyr Ile Thr Ser Leu Asp Leu Ser Ala Asn 
            980                 985                 990         


Glu Leu Arg Asp Ile Asp Ala Leu  Ser Gln Lys Cys Cys  Ile Ser Val 
        995                 1000                 1005             


His Leu  Glu His Leu Glu Lys  Leu Glu Leu His Gln  Asn Ala Leu 
    1010                 1015                 1020             


Thr Ser  Phe Pro Gln Gln Leu  Cys Glu Thr Leu Lys  Ser Leu Thr 
    1025                 1030                 1035             


His Leu  Asp Leu His Ser Asn  Lys Phe Thr Ser Phe  Pro Ser Tyr 
    1040                 1045                 1050             


Leu Leu  Lys Met Ser Cys Ile  Ala Asn Leu Asp Val  Ser Arg Asn 
    1055                 1060                 1065             


Asp Ile  Gly Pro Ser Val Val  Leu Asp Pro Thr Val  Lys Cys Pro 
    1070                 1075                 1080             


Thr Leu  Lys Gln Phe Asn Leu  Ser Tyr Asn Gln Leu  Ser Phe Val 
    1085                 1090                 1095             


Pro Glu  Asn Leu Thr Asp Val  Val Glu Lys Leu Glu  Gln Leu Ile 
    1100                 1105                 1110             


Leu Glu  Gly Asn Lys Ile Ser  Gly Ile Cys Ser Pro  Leu Arg Leu 
    1115                 1120                 1125             


Lys Glu  Leu Lys Ile Leu Asn  Leu Ser Lys Asn His  Ile Ser Ser 
    1130                 1135                 1140             


Leu Ser  Glu Asn Phe Leu Glu  Ala Cys Pro Lys Val  Glu Ser Phe 
    1145                 1150                 1155             


Ser Ala  Arg Met Asn Phe Leu  Ala Ala Met Pro Phe  Leu Pro Pro 
    1160                 1165                 1170             


Ser Met  Thr Ile Leu Lys Leu  Ser Gln Asn Lys Phe  Ser Cys Ile 
    1175                 1180                 1185             


Pro Glu  Ala Ile Leu Asn Leu  Pro His Leu Arg Ser  Leu Asp Met 
    1190                 1195                 1200             


Ser Ser  Asn Asp Ile Gln Tyr  Leu Pro Gly Pro Ala  His Trp Lys 
    1205                 1210                 1215             


Ser Leu  Asn Leu Arg Glu Leu  Leu Phe Ser His Asn  Gln Ile Ser 
    1220                 1225                 1230             


Ile Leu  Asp Leu Ser Glu Lys  Ala Tyr Leu Trp Ser  Arg Val Glu 
    1235                 1240                 1245             


Lys Leu  His Leu Ser His Asn  Lys Leu Lys Glu Ile  Pro Pro Glu 
    1250                 1255                 1260             


Ile Gly  Cys Leu Glu Asn Leu  Thr Ser Leu Asp Val  Ser Tyr Asn 
    1265                 1270                 1275             


Leu Glu  Leu Arg Ser Phe Pro  Asn Glu Met Gly Lys  Leu Ser Lys 
    1280                 1285                 1290             


Ile Trp  Asp Leu Pro Leu Asp  Glu Leu His Leu Asn  Phe Asp Phe 
    1295                 1300                 1305             


Lys His  Ile Gly Cys Lys Ala  Lys Asp Ile Ile Arg  Phe Leu Gln 
    1310                 1315                 1320             


Gln Arg  Leu Lys Lys Ala Val  Pro Tyr Asn Arg Met  Lys Leu Met 
    1325                 1330                 1335             


Ile Val  Gly Asn Thr Gly Ser  Gly Lys Thr Thr Leu  Leu Gln Gln 
    1340                 1345                 1350             


Leu Met  Lys Thr Lys Lys Ser  Asp Leu Gly Met Gln  Ser Ala Thr 
    1355                 1360                 1365             


Val Gly  Ile Asp Val Lys Asp  Trp Pro Ile Gln Ile  Arg Asp Lys 
    1370                 1375                 1380             


Arg Lys  Arg Asp Leu Val Leu  Asn Val Trp Asp Phe  Ala Gly Arg 
    1385                 1390                 1395             


Glu Glu  Phe Tyr Ser Thr His  Pro His Phe Met Thr  Gln Arg Ala 
    1400                 1405                 1410             


Leu Tyr  Leu Ala Val Tyr Asp  Leu Ser Lys Gly Gln  Ala Glu Val 
    1415                 1420                 1425             


Asp Ala  Met Lys Pro Trp Leu  Phe Asn Ile Lys Ala  Arg Ala Ser 
    1430                 1435                 1440             


Ser Ser  Pro Val Ile Leu Val  Gly Thr His Leu Asp  Val Ser Asp 
    1445                 1450                 1455             


Glu Lys  Gln Arg Lys Ala Cys  Met Ser Lys Ile Thr  Lys Glu Leu 
    1460                 1465                 1470             


Leu Asn  Lys Arg Gly Phe Pro  Ala Ile Arg Asp Tyr  His Phe Val 
    1475                 1480                 1485             


Asn Ala  Thr Glu Glu Ser Asp  Ala Leu Ala Lys Leu  Arg Lys Thr 
    1490                 1495                 1500             


Ile Ile  Asn Glu Ser Leu Asn  Phe Lys Ile Arg Asp  Gln Leu Val 
    1505                 1510                 1515             


Val Gly  Gln Leu Ile Pro Asp  Cys Tyr Val Glu Leu  Glu Lys Ile 
    1520                 1525                 1530             


Ile Leu  Ser Glu Arg Lys Asn  Val Pro Ile Glu Phe  Pro Val Ile 
    1535                 1540                 1545             


Asp Arg  Lys Arg Leu Leu Gln  Leu Val Arg Glu Asn  Gln Leu Gln 
    1550                 1555                 1560             


Leu Asp  Glu Asn Glu Leu Pro  His Ala Val His Phe  Leu Asn Glu 
    1565                 1570                 1575             


Ser Gly  Val Leu Leu His Phe  Gln Asp Pro Ala Leu  Gln Leu Ser 
    1580                 1585                 1590             


Asp Leu  Tyr Phe Val Glu Pro  Lys Trp Leu Cys Lys  Ile Met Ala 
    1595                 1600                 1605             


Gln Ile  Leu Thr Val Lys Val  Glu Gly Cys Pro Lys  His Pro Lys 
    1610                 1615                 1620             


Gly Ile  Ile Ser Arg Arg Asp  Val Glu Lys Phe Leu  Ser Lys Lys 
    1625                 1630                 1635             


Arg Lys  Phe Pro Lys Asn Tyr  Met Ser Gln Tyr Phe  Lys Leu Leu 
    1640                 1645                 1650             


Glu Lys  Phe Gln Ile Ala Leu  Pro Ile Gly Glu Glu  Tyr Leu Leu 
    1655                 1660                 1665             


Val Pro  Ser Ser Leu Ser Asp  His Arg Pro Val Ile  Glu Leu Pro 
    1670                 1675                 1680             


His Cys  Glu Asn Ser Glu Ile  Ile Ile Arg Leu Tyr  Glu Met Pro 
    1685                 1690                 1695             


Tyr Phe  Pro Met Gly Phe Trp  Ser Arg Leu Ile Asn  Arg Leu Leu 
    1700                 1705                 1710             


Glu Ile  Ser Pro Tyr Met Leu  Ser Gly Arg Glu Arg  Ala Leu Arg 
    1715                 1720                 1725             


Pro Asn  Arg Met Tyr Trp Arg  Gln Gly Ile Tyr Leu  Asn Trp Ser 
    1730                 1735                 1740             


Pro Glu  Ala Tyr Cys Leu Val  Gly Ser Glu Val Leu  Asp Asn His 
    1745                 1750                 1755             


Pro Glu  Ser Phe Leu Lys Ile  Thr Val Pro Ser Cys  Arg Lys Gly 
    1760                 1765                 1770             


Cys Ile  Leu Leu Gly Gln Val  Val Asp His Ile Asp  Ser Leu Met 
    1775                 1780                 1785             


Glu Glu  Trp Phe Pro Gly Leu  Leu Glu Ile Asp Ile  Cys Gly Glu 
    1790                 1795                 1800             


Gly Glu  Thr Leu Leu Lys Lys  Trp Ala Leu Tyr Ser  Phe Asn Asp 
    1805                 1810                 1815             


Gly Glu  Glu His Gln Lys Ile  Leu Leu Asp Asp Leu  Met Lys Lys 
    1820                 1825                 1830             


Ala Glu  Glu Gly Asp Leu Leu  Val Asn Pro Asp Gln  Pro Arg Leu 
    1835                 1840                 1845             


Thr Ile  Pro Ile Ser Gln Ile  Ala Pro Asp Leu Ile  Leu Ala Asp 
    1850                 1855                 1860             


Leu Pro  Arg Asn Ile Met Leu  Asn Asn Asp Glu Leu  Glu Phe Glu 
    1865                 1870                 1875             


Gln Ala  Pro Glu Phe Leu Leu  Gly Asp Gly Ser Phe  Gly Ser Val 
    1880                 1885                 1890             


Tyr Arg  Ala Ala Tyr Glu Gly  Glu Glu Val Ala Val  Lys Ile Phe 
    1895                 1900                 1905             


Asn Lys  His Thr Ser Leu Arg  Leu Leu Arg Gln Glu  Leu Val Val 
    1910                 1915                 1920             


Leu Cys  His Leu His His Pro  Ser Leu Ile Ser Leu  Leu Ala Ala 
    1925                 1930                 1935             


Gly Ile  Arg Pro Arg Met Leu  Val Met Glu Leu Ala  Ser Lys Gly 
    1940                 1945                 1950             


Ser Leu  Asp Arg Leu Leu Gln  Gln Asp Lys Ala Ser  Leu Thr Arg 
    1955                 1960                 1965             


Thr Leu  Gln His Arg Ile Ala  Leu His Val Ala Asp  Gly Leu Arg 
    1970                 1975                 1980             


Tyr Leu  His Ser Ala Met Ile  Ile Tyr Arg Asp Leu  Lys Pro His 
    1985                 1990                 1995             


Asn Val  Leu Leu Phe Thr Leu  Tyr Pro Asn Ala Ala  Ile Ile Ala 
    2000                 2005                 2010             


Lys Ile  Ala Asp Tyr Gly Ile  Ala Gln Tyr Cys Cys  Arg Met Gly 
    2015                 2020                 2025             


Ile Lys  Thr Ser Glu Gly Thr  Pro Gly Phe Arg Ala  Pro Glu Val 
    2030                 2035                 2040             


Ala Arg  Gly Asn Val Ile Tyr  Asn Gln Gln Ala Asp  Val Tyr Ser 
    2045                 2050                 2055             


Phe Gly  Leu Leu Leu Tyr Asp  Ile Leu Thr Thr Gly  Gly Arg Ile 
    2060                 2065                 2070             


Val Glu  Gly Leu Lys Phe Pro  Asn Glu Phe Asp Glu  Leu Glu Ile 
    2075                 2080                 2085             


Gln Gly  Lys Leu Pro Asp Pro  Val Lys Glu Tyr Gly  Cys Ala Pro 
    2090                 2095                 2100             


Trp Pro  Met Val Glu Lys Leu  Ile Lys Gln Cys Leu  Lys Glu Asn 
    2105                 2110                 2115             


Pro Gln  Glu Arg Pro Thr Ser  Ala Gln Val Phe Asp  Ile Leu Asn 
    2120                 2125                 2130             


Ser Ala  Glu Leu Val Cys Leu  Thr Arg Arg Ile Leu  Leu Pro Lys 
    2135                 2140                 2145             


Asn Val  Ile Val Glu Cys Met  Val Ala Thr His His  Asn Ser Arg 
    2150                 2155                 2160             


Asn Ala  Ser Ile Trp Leu Gly  Cys Gly His Thr Asp  Arg Gly Gln 
    2165                 2170                 2175             


Leu Ser  Phe Leu Asp Leu Asn  Thr Glu Gly Tyr Thr  Ser Glu Glu 
    2180                 2185                 2190             


Val Ala  Asp Ser Arg Ile Leu  Cys Leu Ala Leu Val  His Leu Pro 
    2195                 2200                 2205             


Val Glu  Lys Glu Ser Trp Ile  Val Ser Gly Thr Gln  Ser Gly Thr 
    2210                 2215                 2220             


Leu Leu  Val Ile Asn Thr Glu  Asp Gly Lys Lys Arg  His Thr Leu 
    2225                 2230                 2235             


Glu Lys  Met Thr Asp Ser Val  Thr Cys Leu Tyr Cys  Asn Ser Phe 
    2240                 2245                 2250             


Ser Lys  Gln Ser Lys Gln Lys  Asn Phe Leu Leu Val  Gly Thr Ala 
    2255                 2260                 2265             


Asp Gly  Lys Leu Ala Ile Phe  Glu Asp Lys Thr Val  Lys Leu Lys 
    2270                 2275                 2280             


Gly Ala  Ala Pro Leu Lys Ile  Leu Asn Ile Gly Asn  Val Ser Thr 
    2285                 2290                 2295             


Pro Leu  Met Cys Leu Ser Glu  Ser Thr Asn Ser Thr  Glu Arg Asn 
    2300                 2305                 2310             


Val Met  Trp Gly Gly Cys Gly  Thr Lys Ile Phe Ser  Phe Ser Asn 
    2315                 2320                 2325             


Asp Phe  Thr Ile Gln Lys Leu  Ile Glu Thr Arg Thr  Ser Gln Leu 
    2330                 2335                 2340             


Phe Ser  Tyr Ala Ala Phe Ser  Asp Ser Asn Ile Ile  Thr Val Val 
    2345                 2350                 2355             


Val Asp  Thr Ala Leu Tyr Ile  Ala Lys Gln Asn Ser  Pro Val Val 
    2360                 2365                 2370             


Glu Val  Trp Asp Lys Lys Thr  Glu Lys Leu Cys Gly  Leu Ile Asp 
    2375                 2380                 2385             


Cys Val  His Phe Leu Arg Glu  Val Met Val Lys Glu  Asn Lys Glu 
    2390                 2395                 2400             


Ser Lys  His Lys Met Ser Tyr  Ser Gly Arg Val Lys  Thr Leu Cys 
    2405                 2410                 2415             


Leu Gln  Lys Asn Thr Ala Leu  Trp Ile Gly Thr Gly  Gly Gly His 
    2420                 2425                 2430             


Ile Leu  Leu Leu Asp Leu Ser  Thr Arg Arg Leu Ile  Arg Val Ile 
    2435                 2440                 2445             


Tyr Asn  Phe Cys Asn Ser Val  Arg Val Met Met Thr  Ala Gln Leu 
    2450                 2455                 2460             


Gly Ser  Leu Lys Asn Val Met  Leu Val Leu Gly Tyr  Asn Arg Lys 
    2465                 2470                 2475             


Asn Thr  Glu Gly Thr Gln Lys  Gln Lys Glu Ile Gln  Ser Cys Leu 
    2480                 2485                 2490             


Thr Val  Trp Asp Ile Asn Leu  Pro His Glu Val Gln  Asn Leu Glu 
    2495                 2500                 2505             


Lys His  Ile Glu Val Arg Lys  Glu Leu Ala Glu Lys  Met Arg Arg 
    2510                 2515                 2520             


Thr Ser  Val Glu 
    2525         


<210>  58
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 140 


<210>  59
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59

Met His Arg Gly Val Gly Pro Ala Phe Arg Val Val Arg Lys Met Ala 
1               5                   10                  15      


Ala Ser Gly Ala Glu Pro Gln Val Leu Val Gln Tyr Leu Val Leu Arg 
            20                  25                  30          


Lys Asp Leu Ser Gln Ala Pro Phe Ser Trp Pro Ala Gly Ala Leu Val 
        35                  40                  45              


Ala Gln Ala Cys His Ala Ala Thr Ala Ala Leu His Thr His Arg Asp 
    50                  55                  60                  


His Pro His Thr Ala Ala Tyr Leu Gln Glu Leu Gly Arg Met Arg Lys 
65                  70                  75                  80  


Val Val Leu Glu Ala Pro Asp Glu Thr Thr Leu Lys Glu Leu Ala Glu 
                85                  90                  95      


Thr Leu Gln Gln Lys Asn Ile Asp His Met Leu Trp Leu Glu Gln Pro 
            100                 105                 110         


Glu Asn Ile Ala Thr Cys Ile Ala Leu Arg Pro Tyr Pro Lys Glu Glu 
        115                 120                 125             


Val Gly Gln Tyr Leu Lys Lys Phe Arg Leu Phe Lys 
    130                 135                 140 


<210>  60
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60

Met Ala Val Arg Gln Ala Leu Gly Arg Gly Leu Gln Leu Gly Arg Ala 
1               5                   10                  15      


Leu Leu Leu Arg Phe Thr Gly Lys Pro Gly Arg Ala Tyr Gly Leu Gly 
            20                  25                  30          


Arg Pro Gly Pro Ala Ala Gly Cys Val Arg Gly Glu Arg Pro Gly Trp 
        35                  40                  45              


Ala Ala Gly Pro Gly Ala Glu Pro Arg Arg Val Gly Leu Gly Leu Pro 
    50                  55                  60                  


Asn Arg Leu Arg Phe Phe Arg Gln Ser Val Ala Gly Leu Ala Ala Arg 
65                  70                  75                  80  


Leu Gln Arg Gln Phe Val Val Arg Ala Trp Gly Cys Ala Gly Pro Cys 
                85                  90                  95      


Gly Arg Ala Val Phe Leu Ala Phe Gly Leu Gly Leu Gly Leu Ile Glu 
            100                 105                 110         


Glu Lys Gln Ala Glu Ser Arg Arg Ala Val Ser Ala Cys Gln Glu Ile 
        115                 120                 125             


Gln Ala Ile Phe Thr Gln Lys Ser Lys Pro Gly Pro Asp Pro Leu Asp 
    130                 135                 140                 


Thr Arg Arg Leu Gln Gly Phe Arg Leu Glu Glu Tyr Leu Ile Gly Gln 
145                 150                 155                 160 


Ser Ile Gly Lys Gly Cys Ser Ala Ala Val Tyr Glu Ala Thr Met Pro 
                165                 170                 175     


Thr Leu Pro Gln Asn Leu Glu Val Thr Lys Ser Thr Gly Leu Leu Pro 
            180                 185                 190         


Gly Arg Gly Pro Gly Thr Ser Ala Pro Gly Glu Gly Gln Glu Arg Ala 
        195                 200                 205             


Pro Gly Ala Pro Ala Phe Pro Leu Ala Ile Lys Met Met Trp Asn Ile 
    210                 215                 220                 


Ser Ala Gly Ser Ser Ser Glu Ala Ile Leu Asn Thr Met Ser Gln Glu 
225                 230                 235                 240 


Leu Val Pro Ala Ser Arg Val Ala Leu Ala Gly Glu Tyr Gly Ala Val 
                245                 250                 255     


Thr Tyr Arg Lys Ser Lys Arg Gly Pro Lys Gln Leu Ala Pro His Pro 
            260                 265                 270         


Asn Ile Ile Arg Val Leu Arg Ala Phe Thr Ser Ser Val Pro Leu Leu 
        275                 280                 285             


Pro Gly Ala Leu Val Asp Tyr Pro Asp Val Leu Pro Ser Arg Leu His 
    290                 295                 300                 


Pro Glu Gly Leu Gly His Gly Arg Thr Leu Phe Leu Val Met Lys Asn 
305                 310                 315                 320 


Tyr Pro Cys Thr Leu Arg Gln Tyr Leu Cys Val Asn Thr Pro Ser Pro 
                325                 330                 335     


Arg Leu Ala Ala Met Met Leu Leu Gln Leu Leu Glu Gly Val Asp His 
            340                 345                 350         


Leu Val Gln Gln Gly Ile Ala His Arg Asp Leu Lys Ser Asp Asn Ile 
        355                 360                 365             


Leu Val Glu Leu Asp Pro Asp Gly Cys Pro Trp Leu Val Ile Ala Asp 
    370                 375                 380                 


Phe Gly Cys Cys Leu Ala Asp Glu Ser Ile Gly Leu Gln Leu Pro Phe 
385                 390                 395                 400 


Ser Ser Trp Tyr Val Asp Arg Gly Gly Asn Gly Cys Leu Met Ala Pro 
                405                 410                 415     


Glu Val Ser Thr Ala Arg Pro Gly Pro Arg Ala Val Ile Asp Tyr Ser 
            420                 425                 430         


Lys Ala Asp Ala Trp Ala Val Gly Ala Ile Ala Tyr Glu Ile Phe Gly 
        435                 440                 445             


Leu Val Asn Pro Phe Tyr Gly Gln Gly Lys Ala His Leu Glu Ser Arg 
    450                 455                 460                 


Ser Tyr Gln Glu Ala Gln Leu Pro Ala Leu Pro Glu Ser Val Pro Pro 
465                 470                 475                 480 


Asp Val Arg Gln Leu Val Arg Ala Leu Leu Gln Arg Glu Ala Ser Lys 
                485                 490                 495     


Arg Pro Ser Ala Arg Val Ala Ala Asn Val Leu His Leu Ser Leu Trp 
            500                 505                 510         


Gly Glu His Ile Leu Ala Leu Lys Asn Leu Lys Leu Asp Lys Met Val 
        515                 520                 525             


Gly Trp Leu Leu Gln Gln Ser Ala Ala Thr Leu Leu Ala Asn Arg Leu 
    530                 535                 540                 


Thr Glu Lys Cys Cys Val Glu Thr Lys Met Lys Met Leu Phe Leu Ala 
545                 550                 555                 560 


Asn Leu Glu Cys Glu Thr Leu Cys Gln Ala Ala Leu Leu Leu Cys Ser 
                565                 570                 575     


Trp Arg Ala Ala Leu 
            580     


<210>  61
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61

Met Glu Pro Ala Ala Gly Ile Gln Arg Arg Ser Ser Gln Gly Pro Thr 
1               5                   10                  15      


Val Pro Pro Pro Pro Arg Gly His Ala Pro Pro Ala Ala Ala Pro Gly 
            20                  25                  30          


Pro Ala Pro Leu Ser Ser Pro Val Arg Glu Pro Pro Gln Leu Glu Glu 
        35                  40                  45              


Glu Arg Gln Val Arg Ile Ser Glu Ser Gly Gln Phe Ser Asp Gly Leu 
    50                  55                  60                  


Glu Asp Arg Gly Leu Leu Glu Ser Ser Thr Arg Leu Lys Pro His Glu 
65                  70                  75                  80  


Ala Gln Asn Tyr Arg Lys Lys Ala Leu Trp Val Ser Trp Phe Ser Ile 
                85                  90                  95      


Ile Val Thr Leu Ala Leu Ala Val Ala Ala Phe Thr Val Ser Val Met 
            100                 105                 110         


Arg Tyr Ser Ala Ser Ala Phe Gly Phe Ala Phe Asp Ala Ile Leu Asp 
        115                 120                 125             


Val Leu Ser Ser Ala Ile Val Leu Trp Arg Tyr Ser Asn Ala Ala Ala 
    130                 135                 140                 


Val His Ser Ala His Arg Glu Tyr Ile Ala Cys Val Ile Leu Gly Val 
145                 150                 155                 160 


Ile Phe Leu Leu Ser Ser Ile Cys Ile Val Val Lys Ala Ile His Asp 
                165                 170                 175     


Leu Ser Thr Arg Leu Leu Pro Glu Val Asp Asp Phe Leu Phe Ser Val 
            180                 185                 190         


Ser Ile Leu Ser Gly Ile Leu Cys Ser Ile Leu Ala Val Leu Lys Phe 
        195                 200                 205             


Met Leu Gly Lys Val Leu Thr Ser Arg Ala Leu Ile Thr Asp Gly Phe 
    210                 215                 220                 


Asn Ser Leu Val Gly Gly Val Met Gly Phe Ser Ile Leu Leu Ser Ala 
225                 230                 235                 240 


Glu Val Phe Lys His Asp Ser Ala Val Trp Tyr Leu Asp Gly Ser Ile 
                245                 250                 255     


Gly Val Leu Ile Gly Leu Thr Ile Phe Ala Tyr Gly Val Lys Leu Leu 
            260                 265                 270         


Ile Asp Met Val Pro Arg Val Arg Gln Thr Arg His Tyr Glu Met Phe 
        275                 280                 285             


Glu 
    


<210>  62
<211>  1311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Met Ser Leu Leu Gln Ser Ala Leu Asp Phe Leu Ala Gly Pro Gly Ser 
1               5                   10                  15      


Leu Gly Gly Ala Ser Gly Arg Asp Gln Ser Asp Phe Val Gly Gln Thr 
            20                  25                  30          


Val Glu Leu Gly Glu Leu Arg Leu Arg Val Arg Arg Val Leu Ala Glu 
        35                  40                  45              


Gly Gly Phe Ala Phe Val Tyr Glu Ala Gln Asp Val Gly Ser Gly Arg 
    50                  55                  60                  


Glu Tyr Ala Leu Lys Arg Leu Leu Ser Asn Glu Glu Glu Lys Asn Arg 
65                  70                  75                  80  


Ala Ile Ile Gln Glu Val Cys Phe Met Lys Lys Leu Ser Gly His Pro 
                85                  90                  95      


Asn Ile Val Gln Phe Cys Ser Ala Ala Ser Ile Gly Lys Glu Glu Ser 
            100                 105                 110         


Asp Thr Gly Gln Ala Glu Phe Leu Leu Leu Thr Glu Leu Cys Lys Gly 
        115                 120                 125             


Gln Leu Val Glu Phe Leu Lys Lys Met Glu Ser Arg Gly Pro Leu Ser 
    130                 135                 140                 


Cys Asp Thr Val Leu Lys Ile Phe Tyr Gln Thr Cys Arg Ala Val Gln 
145                 150                 155                 160 


His Met His Arg Gln Lys Pro Pro Ile Ile His Arg Asp Leu Lys Val 
                165                 170                 175     


Glu Asn Leu Leu Leu Ser Asn Gln Gly Thr Ile Lys Leu Cys Asp Phe 
            180                 185                 190         


Gly Ser Ala Thr Thr Ile Ser His Tyr Pro Asp Tyr Ser Trp Ser Ala 
        195                 200                 205             


Gln Arg Arg Ala Leu Val Glu Glu Glu Ile Thr Arg Asn Thr Thr Pro 
    210                 215                 220                 


Met Tyr Arg Thr Pro Glu Ile Ile Asp Leu Tyr Ser Asn Phe Pro Ile 
225                 230                 235                 240 


Gly Glu Lys Gln Asp Ile Trp Ala Leu Gly Cys Ile Leu Tyr Leu Leu 
                245                 250                 255     


Cys Phe Arg Gln His Pro Phe Glu Asp Gly Ala Lys Leu Arg Ile Val 
            260                 265                 270         


Asn Gly Lys Tyr Ser Ile Pro Pro His Asp Thr Gln Tyr Thr Val Phe 
        275                 280                 285             


His Ser Leu Ile Arg Ala Met Leu Gln Val Asn Pro Glu Glu Arg Leu 
    290                 295                 300                 


Ser Ile Ala Glu Val Val His Gln Leu Gln Glu Ile Ala Ala Ala Arg 
305                 310                 315                 320 


Asn Val Asn Pro Lys Ser Pro Ile Thr Glu Leu Leu Glu Gln Asn Gly 
                325                 330                 335     


Gly Tyr Gly Ser Ala Thr Leu Ser Arg Gly Pro Pro Pro Pro Val Gly 
            340                 345                 350         


Pro Ala Gly Ser Gly Tyr Ser Gly Gly Leu Ala Leu Ala Glu Tyr Asp 
        355                 360                 365             


Gln Pro Tyr Gly Gly Phe Leu Asp Ile Leu Arg Gly Gly Thr Glu Arg 
    370                 375                 380                 


Leu Phe Thr Asn Leu Lys Asp Thr Ser Ser Lys Val Ile Gln Ser Val 
385                 390                 395                 400 


Ala Asn Tyr Ala Lys Gly Asp Leu Asp Ile Ser Tyr Ile Thr Ser Arg 
                405                 410                 415     


Ile Ala Val Met Ser Phe Pro Ala Glu Gly Val Glu Ser Ala Leu Lys 
            420                 425                 430         


Asn Asn Ile Glu Asp Val Arg Leu Phe Leu Asp Ser Lys His Pro Gly 
        435                 440                 445             


His Tyr Ala Val Tyr Asn Leu Ser Pro Arg Thr Tyr Arg Pro Ser Arg 
    450                 455                 460                 


Phe His Asn Arg Val Ser Glu Cys Gly Trp Ala Ala Arg Arg Ala Pro 
465                 470                 475                 480 


His Leu His Thr Leu Tyr Asn Ile Cys Arg Asn Met His Ala Trp Leu 
                485                 490                 495     


Arg Gln Asp His Lys Asn Val Cys Val Val His Cys Met Asp Gly Arg 
            500                 505                 510         


Ala Ala Ser Ala Val Ala Val Cys Ser Phe Leu Cys Phe Cys Arg Leu 
        515                 520                 525             


Phe Ser Thr Ala Glu Ala Ala Val Tyr Met Phe Ser Met Lys Arg Cys 
    530                 535                 540                 


Pro Pro Gly Ile Trp Pro Ser His Lys Arg Tyr Ile Glu Tyr Met Cys 
545                 550                 555                 560 


Asp Met Val Ala Glu Glu Pro Ile Thr Pro His Ser Lys Pro Ile Leu 
                565                 570                 575     


Val Arg Ala Val Val Met Thr Pro Val Pro Leu Phe Ser Lys Gln Arg 
            580                 585                 590         


Ser Gly Cys Arg Pro Phe Cys Glu Val Tyr Val Gly Asp Glu Arg Val 
        595                 600                 605             


Ala Ser Thr Ser Gln Glu Tyr Asp Lys Met Arg Asp Phe Lys Ile Glu 
    610                 615                 620                 


Asp Gly Lys Ala Val Ile Pro Leu Gly Val Thr Val Gln Gly Asp Val 
625                 630                 635                 640 


Leu Ile Val Ile Tyr His Ala Arg Ser Thr Leu Gly Gly Arg Leu Gln 
                645                 650                 655     


Ala Lys Met Ala Ser Met Lys Met Phe Gln Ile Gln Phe His Thr Gly 
            660                 665                 670         


Phe Val Pro Arg Asn Ala Thr Thr Val Lys Phe Ala Lys Tyr Asp Leu 
        675                 680                 685             


Asp Ala Cys Asp Ile Gln Glu Lys Tyr Pro Asp Leu Phe Gln Val Asn 
    690                 695                 700                 


Leu Glu Val Glu Val Glu Pro Arg Asp Arg Pro Ser Arg Glu Ala Pro 
705                 710                 715                 720 


Pro Trp Glu Asn Ser Ser Met Arg Gly Leu Asn Pro Lys Ile Leu Phe 
                725                 730                 735     


Ser Ser Arg Glu Glu Gln Gln Asp Ile Leu Ser Lys Phe Gly Lys Pro 
            740                 745                 750         


Glu Leu Pro Arg Gln Pro Gly Ser Thr Ala Gln Tyr Asp Ala Gly Ala 
        755                 760                 765             


Gly Ser Pro Glu Ala Glu Pro Thr Asp Ser Asp Ser Pro Pro Ser Ser 
    770                 775                 780                 


Ser Ala Asp Ala Ser Arg Phe Leu His Thr Leu Asp Trp Gln Glu Glu 
785                 790                 795                 800 


Lys Glu Ala Glu Thr Gly Ala Glu Asn Ala Ser Ser Lys Glu Ser Glu 
                805                 810                 815     


Ser Ala Leu Met Glu Asp Arg Asp Glu Ser Glu Val Ser Asp Glu Gly 
            820                 825                 830         


Gly Ser Pro Ile Ser Ser Glu Gly Gln Glu Pro Arg Ala Asp Pro Glu 
        835                 840                 845             


Pro Pro Gly Leu Ala Ala Gly Leu Val Gln Gln Asp Leu Val Phe Glu 
    850                 855                 860                 


Val Glu Thr Pro Ala Val Leu Pro Glu Pro Val Pro Gln Glu Asp Gly 
865                 870                 875                 880 


Val Asp Leu Leu Gly Leu His Ser Glu Val Gly Ala Gly Pro Ala Val 
                885                 890                 895     


Pro Pro Gln Ala Cys Lys Ala Pro Ser Ser Asn Thr Asp Leu Leu Ser 
            900                 905                 910         


Cys Leu Leu Gly Pro Pro Glu Ala Ala Ser Gln Gly Pro Pro Glu Asp 
        915                 920                 925             


Leu Leu Ser Glu Asp Pro Leu Leu Leu Ala Ser Pro Ala Pro Pro Leu 
    930                 935                 940                 


Ser Val Gln Ser Thr Pro Arg Gly Gly Pro Pro Ala Ala Ala Asp Pro 
945                 950                 955                 960 


Phe Gly Pro Leu Leu Pro Ser Ser Gly Asn Asn Ser Gln Pro Cys Ser 
                965                 970                 975     


Asn Pro Asp Leu Phe Gly Glu Phe Leu Asn Ser Asp Ser Val Thr Val 
            980                 985                 990         


Pro Pro Ser Phe Pro Ser Ala His  Ser Ala Pro Pro Pro  Ser Cys Ser 
        995                 1000                 1005             


Ala Asp  Phe Leu His Leu Gly  Asp Leu Pro Gly Glu  Pro Ser Lys 
    1010                 1015                 1020             


Met Thr  Ala Ser Ser Ser Asn  Pro Asp Leu Leu Gly  Gly Trp Ala 
    1025                 1030                 1035             


Ala Trp  Thr Glu Thr Ala Ala  Ser Ala Val Ala Pro  Thr Pro Ala 
    1040                 1045                 1050             


Thr Glu  Gly Pro Leu Phe Ser  Pro Gly Gly Gln Pro  Ala Pro Cys 
    1055                 1060                 1065             


Gly Ser  Gln Ala Ser Trp Thr  Lys Ser Gln Asn Pro  Asp Pro Phe 
    1070                 1075                 1080             


Ala Asp  Leu Gly Asp Leu Ser  Ser Gly Leu Gln Gly  Ser Pro Ala 
    1085                 1090                 1095             


Gly Phe  Pro Pro Gly Gly Phe  Ile Pro Lys Thr Ala  Thr Thr Pro 
    1100                 1105                 1110             


Lys Gly  Ser Ser Ser Trp Gln  Thr Ser Arg Pro Pro  Ala Gln Gly 
    1115                 1120                 1125             


Ala Ser  Trp Pro Pro Gln Ala  Lys Pro Pro Pro Lys  Ala Cys Thr 
    1130                 1135                 1140             


Gln Pro  Arg Pro Asn Tyr Ala  Ser Asn Phe Ser Val  Ile Gly Ala 
    1145                 1150                 1155             


Arg Glu  Glu Arg Gly Val Arg  Ala Pro Ser Phe Ala  Gln Lys Pro 
    1160                 1165                 1170             


Lys Val  Ser Glu Asn Asp Phe  Glu Asp Leu Leu Ser  Asn Gln Gly 
    1175                 1180                 1185             


Phe Ser  Ser Arg Ser Asp Lys  Lys Gly Pro Lys Thr  Ile Ala Glu 
    1190                 1195                 1200             


Met Arg  Lys Gln Asp Leu Ala  Lys Asp Thr Asp Pro  Leu Lys Leu 
    1205                 1210                 1215             


Lys Leu  Leu Asp Trp Ile Glu  Gly Lys Glu Arg Asn  Ile Arg Ala 
    1220                 1225                 1230             


Leu Leu  Ser Thr Leu His Thr  Val Leu Trp Asp Gly  Glu Ser Arg 
    1235                 1240                 1245             


Trp Thr  Pro Val Gly Met Ala  Asp Leu Val Ala Pro  Glu Gln Val 
    1250                 1255                 1260             


Lys Lys  His Tyr Arg Arg Ala  Val Leu Ala Val His  Pro Asp Lys 
    1265                 1270                 1275             


Ala Ala  Gly Gln Pro Tyr Glu  Gln His Ala Lys Met  Ile Phe Met 
    1280                 1285                 1290             


Glu Leu  Asn Asp Ala Trp Ser  Glu Phe Glu Asn Gln  Gly Ser Arg 
    1295                 1300                 1305             


Pro Leu  Phe 
    1310     


<210>  63
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  63

Met Ala Pro Leu Ala Glu Val Gly Gly Phe Leu Gly Gly Leu Glu Gly 
1               5                   10                  15      


Leu Gly Gln Gln Val Gly Ser His Phe Leu Leu Pro Pro Ala Gly Glu 
            20                  25                  30          


Arg Pro Pro Leu Leu Gly Glu Arg Arg Ser Ala Ala Glu Arg Ser Ala 
        35                  40                  45              


Arg Gly Gly Pro Gly Ala Ala Gln Leu Ala His Leu His Gly Ile Leu 
    50                  55                  60                  


Arg Arg Arg Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Gln Ile Leu 
65                  70                  75                  80  


Pro Asp Gly Ser Val Gln Gly Thr Arg Gln Asp His Ser Leu Phe Gly 
                85                  90                  95      


Ile Leu Glu Phe Ile Ser Val Ala Val Gly Leu Val Ser Ile Arg Gly 
            100                 105                 110         


Val Asp Ser Gly Leu Tyr Leu Gly Met Asn Asp Lys Gly Glu Leu Tyr 
        115                 120                 125             


Gly Ser Glu Lys Leu Thr Ser Glu Cys Ile Phe Arg Glu Gln Phe Glu 
    130                 135                 140                 


Glu Asn Trp Tyr Asn Thr Tyr Ser Ser Asn Ile Tyr Lys His Gly Asp 
145                 150                 155                 160 


Thr Gly Arg Arg Tyr Phe Val Ala Leu Asn Lys Asp Gly Thr Pro Arg 
                165                 170                 175     


Asp Gly Ala Arg Ser Lys Arg His Gln Lys Phe Thr His Phe Leu Pro 
            180                 185                 190         


Arg Pro Val Asp Pro Glu Arg Val Pro Glu Leu Tyr Lys Asp Leu Leu 
        195                 200                 205             


Met Tyr Thr 
    210     


<210>  64
<211>  870
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64

Met Phe Phe Ala Cys Tyr Cys Ala Leu Arg Thr Asn Val Lys Lys Tyr 
1               5                   10                  15      


Arg Tyr Gln Asp Glu Asp Ala Pro His Asp His Ser Leu Pro Arg Leu 
            20                  25                  30          


Thr His Glu Val Arg Gly Pro Glu Leu Val His Val Ser Glu Lys Asn 
        35                  40                  45              


Leu Ser Gln Ile Glu Asn Val His Gly Tyr Val Leu Gln Ser His Ile 
    50                  55                  60                  


Ser Pro Leu Lys Ala Ser Pro Ala Pro Ile Ile Val Asn Thr Asp Thr 
65                  70                  75                  80  


Leu Asp Thr Ile Pro Tyr Val Asn Gly Thr Glu Ile Glu Tyr Glu Phe 
                85                  90                  95      


Glu Glu Ile Thr Leu Glu Arg Gly Asn Ser Gly Leu Gly Phe Ser Ile 
            100                 105                 110         


Ala Gly Gly Thr Asp Asn Pro His Ile Gly Asp Asp Pro Gly Ile Phe 
        115                 120                 125             


Ile Thr Lys Ile Ile Pro Gly Gly Ala Ala Ala Glu Asp Gly Arg Leu 
    130                 135                 140                 


Arg Val Asn Asp Cys Ile Leu Arg Val Asn Glu Val Asp Val Ser Glu 
145                 150                 155                 160 


Val Ser His Ser Lys Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile 
                165                 170                 175     


Val Arg Leu Tyr Val Arg Arg Arg Arg Pro Ile Leu Glu Thr Val Val 
            180                 185                 190         


Glu Ile Lys Leu Phe Lys Gly Pro Lys Gly Leu Gly Phe Ser Ile Ala 
        195                 200                 205             


Gly Gly Val Gly Asn Gln His Ile Pro Gly Asp Asn Ser Ile Tyr Val 
    210                 215                 220                 


Thr Lys Ile Ile Asp Gly Gly Ala Ala Gln Lys Asp Gly Arg Leu Gln 
225                 230                 235                 240 


Val Gly Asp Arg Leu Leu Met Val Asn Asn Tyr Ser Leu Glu Glu Val 
                245                 250                 255     


Thr His Glu Glu Ala Val Ala Ile Leu Lys Asn Thr Ser Glu Val Val 
            260                 265                 270         


Tyr Leu Lys Val Gly Lys Pro Thr Thr Ile Tyr Met Thr Asp Pro Tyr 
        275                 280                 285             


Gly Pro Pro Asp Ile Thr His Ser Tyr Ser Pro Pro Met Glu Asn His 
    290                 295                 300                 


Leu Leu Ser Gly Asn Asn Gly Thr Leu Glu Tyr Lys Thr Ser Leu Pro 
305                 310                 315                 320 


Pro Ile Ser Pro Gly Arg Tyr Ser Pro Ile Pro Lys His Met Leu Val 
                325                 330                 335     


Asp Asp Asp Tyr Thr Arg Pro Pro Glu Pro Val Tyr Ser Thr Val Asn 
            340                 345                 350         


Lys Leu Cys Asp Lys Pro Ala Ser Pro Arg His Tyr Ser Pro Val Glu 
        355                 360                 365             


Cys Asp Lys Ser Phe Leu Leu Ser Ala Pro Tyr Ser His Tyr His Leu 
    370                 375                 380                 


Gly Leu Leu Pro Asp Ser Glu Met Thr Ser His Ser Gln His Ser Thr 
385                 390                 395                 400 


Ala Thr Arg Gln Pro Ser Met Thr Leu Gln Arg Ala Val Ser Leu Glu 
                405                 410                 415     


Gly Glu Pro Arg Lys Val Val Leu His Lys Gly Ser Thr Gly Leu Gly 
            420                 425                 430         


Phe Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Val Ser Phe 
        435                 440                 445             


Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Gln Arg Gly 
    450                 455                 460                 


Asp Gln Ile Leu Ser Val Asn Gly Ile Asp Leu Arg Gly Ala Ser His 
465                 470                 475                 480 


Glu Gln Ala Ala Ala Ala Leu Lys Gly Ala Gly Gln Thr Val Thr Ile 
                485                 490                 495     


Ile Ala Gln Tyr Gln Pro Glu Asp Tyr Ala Arg Phe Glu Ala Lys Ile 
            500                 505                 510         


His Asp Leu Arg Glu Gln Met Met Asn His Ser Met Ser Ser Gly Ser 
        515                 520                 525             


Gly Ser Leu Arg Thr Asn Gln Lys Arg Ser Leu Tyr Val Arg Ala Met 
    530                 535                 540                 


Phe Asp Tyr Asp Lys Ser Lys Asp Ser Gly Leu Pro Ser Gln Gly Leu 
545                 550                 555                 560 


Ser Phe Lys Tyr Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp Asp 
                565                 570                 575     


Glu Trp Trp Gln Ala Arg Arg Val Met Leu Glu Gly Asp Ser Glu Glu 
            580                 585                 590         


Met Gly Val Ile Pro Ser Lys Arg Arg Val Glu Arg Lys Glu Arg Ala 
        595                 600                 605             


Arg Leu Lys Thr Val Lys Phe Asn Ala Lys Pro Gly Val Ile Asp Ser 
    610                 615                 620                 


Lys Gly Ser Phe Asn Asp Lys Arg Lys Lys Ser Phe Ile Phe Ser Arg 
625                 630                 635                 640 


Lys Phe Pro Phe Tyr Lys Asn Lys Glu Gln Ser Glu Gln Glu Thr Ser 
                645                 650                 655     


Asp Pro Glu Arg Gly Gln Glu Asp Leu Ile Leu Ser Tyr Glu Pro Val 
            660                 665                 670         


Thr Arg Gln Glu Ile Asn Tyr Thr Arg Pro Val Ile Ile Leu Gly Pro 
        675                 680                 685             


Met Lys Asp Arg Ile Asn Asp Asp Leu Ile Ser Glu Phe Pro Asp Lys 
    690                 695                 700                 


Phe Gly Ser Cys Val Pro His Thr Thr Arg Pro Lys Arg Asp Tyr Glu 
705                 710                 715                 720 


Val Asp Gly Arg Asp Tyr His Phe Val Ile Ser Arg Glu Gln Met Glu 
                725                 730                 735     


Lys Asp Ile Gln Glu His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Asp 
            740                 745                 750         


Asn Leu Tyr Gly Thr Ser Val Gln Ser Val Arg Phe Val Ala Glu Arg 
        755                 760                 765             


Gly Lys His Cys Ile Leu Asp Val Ser Gly Asn Ala Ile Lys Arg Leu 
    770                 775                 780                 


Gln Val Ala Gln Leu Tyr Pro Ile Ala Ile Phe Ile Lys Pro Arg Ser 
785                 790                 795                 800 


Leu Glu Pro Leu Met Glu Met Asn Lys Arg Leu Thr Glu Glu Gln Ala 
                805                 810                 815     


Lys Lys Thr Tyr Asp Arg Ala Ile Lys Leu Glu Gln Glu Phe Gly Glu 
            820                 825                 830         


Tyr Phe Thr Ala Ile Val Gln Gly Asp Thr Leu Glu Asp Ile Tyr Asn 
        835                 840                 845             


Gln Cys Lys Leu Val Ile Glu Glu Gln Ser Gly Pro Phe Ile Trp Ile 
    850                 855                 860                 


Pro Ser Lys Glu Lys Leu 
865                 870 


<210>  65
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  65

Met Val Ala Pro Val Trp Tyr Leu Val Ala Ala Ala Leu Leu Val Gly 
1               5                   10                  15      


Phe Ile Leu Phe Leu Thr Arg Ser Arg Gly Arg Ala Ala Ser Ala Gly 
            20                  25                  30          


Gln Glu Pro Leu His Asn Glu Glu Leu Ala Gly Ala Gly Arg Val Ala 
        35                  40                  45              


Gln Pro Gly Pro Leu Glu Pro Glu Glu Pro Arg Ala Gly Gly Arg Pro 
    50                  55                  60                  


Arg Arg Arg Arg Asp Leu Gly Ser Arg Leu Gln Ala Gln Arg Arg Ala 
65                  70                  75                  80  


Gln Arg Val Ala Trp Ala Glu Ala Asp Glu Asn Glu Glu Glu Ala Val 
                85                  90                  95      


Ile Leu Ala Gln Glu Glu Glu Gly Val Glu Lys Pro Ala Glu Thr His 
            100                 105                 110         


Leu Ser Gly Lys Ile Gly Ala Lys Lys Leu Arg Lys Leu Glu Glu Lys 
        115                 120                 125             


Gln Ala Arg Lys Ala Gln Arg Glu Ala Glu Glu Ala Glu Arg Glu Glu 
    130                 135                 140                 


Arg Lys Arg Leu Glu Ser Gln Arg Glu Ala Glu Trp Lys Lys Glu Glu 
145                 150                 155                 160 


Glu Arg Leu Arg Leu Glu Glu Glu Gln Lys Glu Glu Glu Glu Arg Lys 
                165                 170                 175     


Ala Arg Glu Glu Gln Ala Gln Arg Glu His Glu Glu Tyr Leu Lys Leu 
            180                 185                 190         


Lys Glu Ala Phe Val Val Glu Glu Glu Gly Val Gly Glu Thr Met Thr 
        195                 200                 205             


Glu Glu Gln Ser Gln Ser Phe Leu Thr Glu Phe Ile Asn Tyr Ile Lys 
    210                 215                 220                 


Gln Ser Lys Val Val Leu Leu Glu Asp Leu Ala Ser Gln Val Gly Leu 
225                 230                 235                 240 


Arg Thr Gln Asp Thr Ile Asn Arg Ile Gln Asp Leu Leu Ala Glu Gly 
                245                 250                 255     


Thr Ile Thr Gly Val Ile Asp Asp Arg Gly Lys Phe Ile Tyr Ile Thr 
            260                 265                 270         


Pro Glu Glu Leu Ala Ala Val Ala Asn Phe Ile Arg Gln Arg Gly Arg 
        275                 280                 285             


Val Ser Ile Ala Glu Leu Ala Gln Ala Ser Asn Ser Leu Ile Ala Trp 
    290                 295                 300                 


Gly Arg Glu Ser Pro Ala Gln Ala Pro Ala 
305                 310                 


<210>  66
<211>  1147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Met Asp Glu Pro Pro Phe Ser Glu Ala Ala Leu Glu Gln Ala Leu Gly 
1               5                   10                  15      


Glu Pro Cys Asp Leu Asp Ala Ala Leu Leu Thr Asp Ile Glu Asp Met 
            20                  25                  30          


Leu Gln Leu Ile Asn Asn Gln Asp Ser Asp Phe Pro Gly Leu Phe Asp 
        35                  40                  45              


Pro Pro Tyr Ala Gly Ser Gly Ala Gly Gly Thr Asp Pro Ala Ser Pro 
    50                  55                  60                  


Asp Thr Ser Ser Pro Gly Ser Leu Ser Pro Pro Pro Ala Thr Leu Ser 
65                  70                  75                  80  


Ser Ser Leu Glu Ala Phe Leu Ser Gly Pro Gln Ala Ala Pro Ser Pro 
                85                  90                  95      


Leu Ser Pro Pro Gln Pro Ala Pro Thr Pro Leu Lys Met Tyr Pro Ser 
            100                 105                 110         


Met Pro Ala Phe Ser Pro Gly Pro Gly Ile Lys Glu Glu Ser Val Pro 
        115                 120                 125             


Leu Ser Ile Leu Gln Thr Pro Thr Pro Gln Pro Leu Pro Gly Ala Leu 
    130                 135                 140                 


Leu Pro Gln Ser Phe Pro Ala Pro Ala Pro Pro Gln Phe Ser Ser Thr 
145                 150                 155                 160 


Pro Val Leu Gly Tyr Pro Ser Pro Pro Gly Gly Phe Ser Thr Gly Ser 
                165                 170                 175     


Pro Pro Gly Asn Thr Gln Gln Pro Leu Pro Gly Leu Pro Leu Ala Ser 
            180                 185                 190         


Pro Pro Gly Val Pro Pro Val Ser Leu His Thr Gln Val Gln Ser Val 
        195                 200                 205             


Val Pro Gln Gln Leu Leu Thr Val Thr Ala Ala Pro Thr Ala Ala Pro 
    210                 215                 220                 


Val Thr Thr Thr Val Thr Ser Gln Ile Gln Gln Val Pro Val Leu Leu 
225                 230                 235                 240 


Gln Pro His Phe Ile Lys Ala Asp Ser Leu Leu Leu Thr Ala Met Lys 
                245                 250                 255     


Thr Asp Gly Ala Thr Val Lys Ala Ala Gly Leu Ser Pro Leu Val Ser 
            260                 265                 270         


Gly Thr Thr Val Gln Thr Gly Pro Leu Pro Thr Leu Val Ser Gly Gly 
        275                 280                 285             


Thr Ile Leu Ala Thr Val Pro Leu Val Val Asp Ala Glu Lys Leu Pro 
    290                 295                 300                 


Ile Asn Arg Leu Ala Ala Gly Ser Lys Ala Pro Ala Ser Ala Gln Ser 
305                 310                 315                 320 


Arg Gly Glu Lys Arg Thr Ala His Asn Ala Ile Glu Lys Arg Tyr Arg 
                325                 330                 335     


Ser Ser Ile Asn Asp Lys Ile Ile Glu Leu Lys Asp Leu Val Val Gly 
            340                 345                 350         


Thr Glu Ala Lys Leu Asn Lys Ser Ala Val Leu Arg Lys Ala Ile Asp 
        355                 360                 365             


Tyr Ile Arg Phe Leu Gln His Ser Asn Gln Lys Leu Lys Gln Glu Asn 
    370                 375                 380                 


Leu Ser Leu Arg Thr Ala Val His Lys Ser Lys Ser Leu Lys Asp Leu 
385                 390                 395                 400 


Val Ser Ala Cys Gly Ser Gly Gly Asn Thr Asp Val Leu Met Glu Gly 
                405                 410                 415     


Val Lys Thr Glu Val Glu Asp Thr Leu Thr Pro Pro Pro Ser Asp Ala 
            420                 425                 430         


Gly Ser Pro Phe Gln Ser Ser Pro Leu Ser Leu Gly Ser Arg Gly Ser 
        435                 440                 445             


Gly Ser Gly Gly Ser Gly Ser Asp Ser Glu Pro Asp Ser Pro Val Phe 
    450                 455                 460                 


Glu Asp Ser Lys Ala Lys Pro Glu Gln Arg Pro Ser Leu His Ser Arg 
465                 470                 475                 480 


Gly Met Leu Asp Arg Ser Arg Leu Ala Leu Cys Thr Leu Val Phe Leu 
                485                 490                 495     


Cys Leu Ser Cys Asn Pro Leu Ala Ser Leu Leu Gly Ala Arg Gly Leu 
            500                 505                 510         


Pro Ser Pro Ser Asp Thr Thr Ser Val Tyr His Ser Pro Gly Arg Asn 
        515                 520                 525             


Val Leu Gly Thr Glu Ser Arg Asp Gly Pro Gly Trp Ala Gln Trp Leu 
    530                 535                 540                 


Leu Pro Pro Val Val Trp Leu Leu Asn Gly Leu Leu Val Leu Val Ser 
545                 550                 555                 560 


Leu Val Leu Leu Phe Val Tyr Gly Glu Pro Val Thr Arg Pro His Ser 
                565                 570                 575     


Gly Pro Ala Val Tyr Phe Trp Arg His Arg Lys Gln Ala Asp Leu Asp 
            580                 585                 590         


Leu Ala Arg Gly Asp Phe Ala Gln Ala Ala Gln Gln Leu Trp Leu Ala 
        595                 600                 605             


Leu Arg Ala Leu Gly Arg Pro Leu Pro Thr Ser His Leu Asp Leu Ala 
    610                 615                 620                 


Cys Ser Leu Leu Trp Asn Leu Ile Arg His Leu Leu Gln Arg Leu Trp 
625                 630                 635                 640 


Val Gly Arg Trp Leu Ala Gly Arg Ala Gly Gly Leu Gln Gln Asp Cys 
                645                 650                 655     


Ala Leu Arg Val Asp Ala Ser Ala Ser Ala Arg Asp Ala Ala Leu Val 
            660                 665                 670         


Tyr His Lys Leu His Gln Leu His Thr Met Gly Lys His Thr Gly Gly 
        675                 680                 685             


His Leu Thr Ala Thr Asn Leu Ala Leu Ser Ala Leu Asn Leu Ala Glu 
    690                 695                 700                 


Cys Ala Gly Asp Ala Val Ser Val Ala Thr Leu Ala Glu Ile Tyr Val 
705                 710                 715                 720 


Ala Ala Ala Leu Arg Val Lys Thr Ser Leu Pro Arg Ala Leu His Phe 
                725                 730                 735     


Leu Thr Arg Phe Phe Leu Ser Ser Ala Arg Gln Ala Cys Leu Ala Gln 
            740                 745                 750         


Ser Gly Ser Val Pro Pro Ala Met Gln Trp Leu Cys His Pro Val Gly 
        755                 760                 765             


His Arg Phe Phe Val Asp Gly Asp Trp Ser Val Leu Ser Thr Pro Trp 
    770                 775                 780                 


Glu Ser Leu Tyr Ser Leu Ala Gly Asn Pro Val Asp Pro Leu Ala Gln 
785                 790                 795                 800 


Val Thr Gln Leu Phe Arg Glu His Leu Leu Glu Arg Ala Leu Asn Cys 
                805                 810                 815     


Val Thr Gln Pro Asn Pro Ser Pro Gly Ser Ala Asp Gly Asp Lys Glu 
            820                 825                 830         


Phe Ser Asp Ala Leu Gly Tyr Leu Gln Leu Leu Asn Ser Cys Ser Asp 
        835                 840                 845             


Ala Ala Gly Ala Pro Ala Tyr Ser Phe Ser Ile Ser Ser Ser Met Ala 
    850                 855                 860                 


Thr Thr Thr Gly Val Asp Pro Val Ala Lys Trp Trp Ala Ser Leu Thr 
865                 870                 875                 880 


Ala Val Val Ile His Trp Leu Arg Arg Asp Glu Glu Ala Ala Glu Arg 
                885                 890                 895     


Leu Cys Pro Leu Val Glu His Leu Pro Arg Val Leu Gln Glu Ser Glu 
            900                 905                 910         


Arg Pro Leu Pro Arg Ala Ala Leu His Ser Phe Lys Ala Ala Arg Ala 
        915                 920                 925             


Leu Leu Gly Cys Ala Lys Ala Glu Ser Gly Pro Ala Ser Leu Thr Ile 
    930                 935                 940                 


Cys Glu Lys Ala Ser Gly Tyr Leu Gln Asp Ser Leu Ala Thr Thr Pro 
945                 950                 955                 960 


Ala Ser Ser Ser Ile Asp Lys Ala Val Gln Leu Phe Leu Cys Asp Leu 
                965                 970                 975     


Leu Leu Val Val Arg Thr Ser Leu Trp Arg Gln Gln Gln Pro Pro Ala 
            980                 985                 990         


Pro Ala Pro Ala Ala Gln Gly Thr  Ser Ser Arg Pro Gln  Ala Ser Ala 
        995                 1000                 1005             


Leu Glu  Leu Arg Gly Phe Gln  Arg Asp Leu Ser Ser  Leu Arg Arg 
    1010                 1015                 1020             


Leu Ala  Gln Ser Phe Arg Pro  Ala Met Arg Arg Val  Phe Leu His 
    1025                 1030                 1035             


Glu Ala  Thr Ala Arg Leu Met  Ala Gly Ala Ser Pro  Thr Arg Thr 
    1040                 1045                 1050             


His Gln  Leu Leu Asp Arg Ser  Leu Arg Arg Arg Ala  Gly Pro Gly 
    1055                 1060                 1065             


Gly Lys  Gly Gly Ala Val Ala  Glu Leu Glu Pro Arg  Pro Thr Arg 
    1070                 1075                 1080             


Arg Glu  His Ala Glu Ala Leu  Leu Leu Ala Ser Cys  Tyr Leu Pro 
    1085                 1090                 1095             


Pro Gly  Phe Leu Ser Ala Pro  Gly Gln Arg Val Gly  Met Leu Ala 
    1100                 1105                 1110             


Glu Ala  Ala Arg Thr Leu Glu  Lys Leu Gly Asp Arg  Arg Leu Leu 
    1115                 1120                 1125             


His Asp  Cys Gln Gln Met Leu  Met Arg Leu Gly Gly  Gly Thr Thr 
    1130                 1135                 1140             


Val Thr  Ser Ser 
    1145         


<210>  67
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67

Met Ile Leu Ala Ser Val Leu Arg Ser Gly Pro Gly Gly Gly Leu Pro 
1               5                   10                  15      


Leu Arg Pro Leu Leu Gly Pro Ala Leu Ala Leu Arg Ala Arg Ser Thr 
            20                  25                  30          


Ser Ala Thr Asp Thr His His Val Glu Met Ala Arg Glu Arg Ser Lys 
        35                  40                  45              


Thr Val Thr Ser Phe Tyr Asn Gln Ser Ala Ile Asp Ala Ala Ala Glu 
    50                  55                  60                  


Lys Pro Ser Val Arg Leu Thr Pro Thr Met Met Leu Tyr Ala Gly Arg 
65                  70                  75                  80  


Ser Gln Asp Gly Ser His Leu Leu Lys Ser Ala Arg Tyr Leu Gln Gln 
                85                  90                  95      


Glu Leu Pro Val Arg Ile Ala His Arg Ile Lys Gly Phe Arg Cys Leu 
            100                 105                 110         


Pro Phe Ile Ile Gly Cys Asn Pro Thr Ile Leu His Val His Glu Leu 
        115                 120                 125             


Tyr Ile Arg Ala Phe Gln Lys Leu Thr Asp Phe Pro Pro Ile Lys Asp 
    130                 135                 140                 


Gln Ala Asp Glu Ala Gln Tyr Cys Gln Leu Val Arg Gln Leu Leu Asp 
145                 150                 155                 160 


Asp His Lys Asp Val Val Thr Leu Leu Ala Glu Gly Leu Arg Glu Ser 
                165                 170                 175     


Arg Lys His Ile Glu Asp Glu Lys Leu Val Arg Tyr Phe Leu Asp Lys 
            180                 185                 190         


Thr Leu Thr Ser Arg Leu Gly Ile Arg Met Leu Ala Thr His His Leu 
        195                 200                 205             


Ala Leu His Glu Asp Lys Pro Asp Phe Val Gly Ile Ile Cys Thr Arg 
    210                 215                 220                 


Leu Ser Pro Lys Lys Ile Ile Glu Lys Trp Val Asp Phe Ala Arg Arg 
225                 230                 235                 240 


Leu Cys Glu His Lys Tyr Gly Asn Ala Pro Arg Val Arg Ile Asn Gly 
                245                 250                 255     


His Val Ala Ala Arg Phe Pro Phe Ile Pro Met Pro Leu Asp Tyr Ile 
            260                 265                 270         


Leu Pro Glu Leu Leu Lys Asn Ala Met Arg Ala Thr Met Glu Ser His 
        275                 280                 285             


Leu Asp Thr Pro Tyr Asn Val Pro Asp Val Val Ile Thr Ile Ala Asn 
    290                 295                 300                 


Asn Asp Val Asp Leu Ile Ile Arg Ile Ser Asp Arg Gly Gly Gly Ile 
305                 310                 315                 320 


Ala His Lys Asp Leu Asp Arg Val Met Asp Tyr His Phe Thr Thr Ala 
                325                 330                 335     


Glu Ala Ser Thr Gln Asp Pro Arg Ile Ser Pro Leu Phe Gly His Leu 
            340                 345                 350         


Asp Met His Ser Gly Ala Gln Ser Gly Pro Met His Gly Phe Gly Phe 
        355                 360                 365             


Gly Leu Pro Thr Ser Arg Ala Tyr Ala Glu Tyr Leu Gly Gly Ser Leu 
    370                 375                 380                 


Gln Leu Gln Ser Leu Gln Gly Ile Gly Thr Asp Val Tyr Leu Arg Leu 
385                 390                 395                 400 


Arg His Ile Asp Gly Arg Glu Glu Ser Phe Arg Ile 
                405                 410         


<210>  68
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68

Met Ile Val Phe Val Arg Phe Asn Ser Ser His Gly Phe Pro Val Glu 
1               5                   10                  15      


Val Asp Ser Asp Thr Ser Ile Phe Gln Leu Lys Glu Val Val Ala Lys 
            20                  25                  30          


Arg Gln Gly Val Pro Ala Asp Gln Leu Arg Val Ile Phe Ala Gly Lys 
        35                  40                  45              


Glu Leu Arg Asn Asp Trp Thr Val Gln Asn Cys Asp Leu Asp Gln Gln 
    50                  55                  60                  


Ser Ile Val His Ile Val Gln Arg Pro Trp Arg Lys Gly Gln Glu Met 
65                  70                  75                  80  


Asn Ala Thr Gly Gly Asp Asp Pro Arg Asn Ala Ala Gly Gly Cys Glu 
                85                  90                  95      


Arg Glu Pro Gln Ser Leu Thr Arg Val Asp Leu Ser Ser Ser Val Leu 
            100                 105                 110         


Pro Gly Asp Ser Val Gly Leu Ala Val Ile Leu His Thr Asp Ser Arg 
        115                 120                 125             


Lys Asp Ser Pro Pro Ala Gly Ser Pro Ala Gly Arg Ser Ile Tyr Asn 
    130                 135                 140                 


Ser Phe Tyr Val Tyr Cys Lys Gly Pro Cys Gln Arg Val Gln Pro Gly 
145                 150                 155                 160 


Lys Leu Arg Val Gln Cys Ser Thr Cys Arg Gln Ala Thr Leu Thr Leu 
                165                 170                 175     


Thr Gln Gly Pro Ser Cys Trp Asp Asp Val Leu Ile Pro Asn Arg Met 
            180                 185                 190         


Ser Gly Glu Cys Gln Ser Pro His Cys Pro Gly Thr Ser Ala Glu Phe 
        195                 200                 205             


Phe Phe Lys Cys Gly Ala His Pro Thr Ser Asp Lys Glu Thr Ser Val 
    210                 215                 220                 


Ala Leu His Leu Ile Ala Thr Asn Ser Arg Asn Ile Thr Cys Ile Thr 
225                 230                 235                 240 


Cys Thr Asp Val Arg Ser Pro Val Leu Val Phe Gln Cys Asn Ser Arg 
                245                 250                 255     


His Val Ile Cys Leu Asp Cys Phe His Leu Tyr Cys Val Thr Arg Leu 
            260                 265                 270         


Asn Asp Arg Gln Phe Val His Asp Pro Gln Leu Gly Tyr Ser Leu Pro 
        275                 280                 285             


Cys Val Ala Gly Cys Pro Asn Ser Leu Ile Lys Glu Leu His His Phe 
    290                 295                 300                 


Arg Ile Leu Gly Glu Glu Gln Tyr Asn Arg Tyr Gln Gln Tyr Gly Ala 
305                 310                 315                 320 


Glu Glu Cys Val Leu Gln Met Gly Gly Val Leu Cys Pro Arg Pro Gly 
                325                 330                 335     


Cys Gly Ala Gly Leu Leu Pro Glu Pro Asp Gln Arg Lys Val Thr Cys 
            340                 345                 350         


Glu Gly Gly Asn Gly Leu Gly Cys Gly Phe Ala Phe Cys Arg Glu Cys 
        355                 360                 365             


Lys Glu Ala Tyr His Glu Gly Glu Cys Ser Ala Val Phe Glu Ala Ser 
    370                 375                 380                 


Gly Thr Thr Thr Gln Ala Tyr Arg Val Asp Glu Arg Ala Ala Glu Gln 
385                 390                 395                 400 


Ala Arg Trp Glu Ala Ala Ser Lys Glu Thr Ile Lys Lys Thr Thr Lys 
                405                 410                 415     


Pro Cys Pro Arg Cys His Val Pro Val Glu Lys Asn Gly Gly Cys Met 
            420                 425                 430         


His Met Lys Cys Pro Gln Pro Gln Cys Arg Leu Glu Trp Cys Trp Asn 
        435                 440                 445             


Cys Gly Cys Glu Trp Asn Arg Val Cys Met Gly Asp His Trp Phe Asp 
    450                 455                 460                 


Val 
465 


<210>  69
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  69

Met Glu Ala Ile Trp Leu Tyr Gln Phe Arg Leu Ile Val Ile Gly Asp 
1               5                   10                  15      


Ser Thr Val Gly Lys Ser Cys Leu Ile Arg Arg Phe Thr Glu Gly Arg 
            20                  25                  30          


Phe Ala Gln Val Ser Asp Pro Thr Val Gly Val Asp Phe Phe Ser Arg 
        35                  40                  45              


Leu Val Glu Ile Glu Pro Gly Lys Arg Ile Lys Leu Gln Ile Trp Asp 
    50                  55                  60                  


Thr Ala Gly Gln Glu Arg Phe Arg Ser Ile Thr Arg Ala Tyr Tyr Arg 
65                  70                  75                  80  


Asn Ser Val Gly Gly Leu Leu Leu Phe Asp Ile Thr Asn Arg Arg Ser 
                85                  90                  95      


Phe Gln Asn Val His Glu Trp Leu Glu Glu Thr Lys Val His Val Gln 
            100                 105                 110         


Pro Tyr Gln Ile Val Phe Val Leu Val Gly His Lys Cys Asp Leu Asp 
        115                 120                 125             


Thr Gln Arg Gln Val Thr Arg His Glu Ala Glu Lys Leu Ala Ala Ala 
    130                 135                 140                 


Tyr Gly Met Lys Tyr Ile Glu Thr Ser Ala Arg Asp Ala Ile Asn Val 
145                 150                 155                 160 


Glu Lys Ala Phe Thr Asp Leu Thr Arg Asp Ile Tyr Glu Leu Val Lys 
                165                 170                 175     


Arg Gly Glu Ile Thr Ile Gln Glu Gly Trp Glu Gly Val Lys Ser Gly 
            180                 185                 190         


Phe Val Pro Asn Val Val His Ser Ser Glu Glu Val Val Lys Ser Glu 
        195                 200                 205             


Arg Arg Cys Leu Cys 
    210             


<210>  70
<211>  913
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70

Met Lys Asp Ser Glu Asn Lys Gly Ala Ser Ser Pro Asp Met Glu Pro 
1               5                   10                  15      


Ser Tyr Gly Gly Gly Leu Phe Asp Met Val Lys Gly Gly Ala Gly Arg 
            20                  25                  30          


Leu Phe Ser Asn Leu Lys Asp Asn Leu Lys Asp Thr Leu Lys Asp Thr 
        35                  40                  45              


Ser Ser Arg Val Ile Gln Ser Val Thr Ser Tyr Thr Lys Gly Asp Leu 
    50                  55                  60                  


Asp Phe Thr Tyr Val Thr Ser Arg Ile Ile Val Met Ser Phe Pro Leu 
65                  70                  75                  80  


Asp Asn Val Asp Ile Gly Phe Arg Asn Gln Val Asp Asp Ile Arg Ser 
                85                  90                  95      


Phe Leu Asp Ser Arg His Leu Asp His Tyr Thr Val Tyr Asn Leu Ser 
            100                 105                 110         


Pro Lys Ser Tyr Arg Thr Ala Lys Phe His Ser Arg Val Ser Glu Cys 
        115                 120                 125             


Ser Trp Pro Ile Arg Gln Ala Pro Ser Leu His Asn Leu Phe Ala Val 
    130                 135                 140                 


Cys Arg Asn Met Tyr Asn Trp Leu Leu Gln Asn Pro Lys Asn Val Cys 
145                 150                 155                 160 


Val Val His Cys Leu Asp Gly Arg Ala Ala Ser Ser Ile Leu Val Gly 
                165                 170                 175     


Ala Met Phe Ile Phe Cys Asn Leu Tyr Ser Thr Pro Gly Pro Ala Ile 
            180                 185                 190         


Arg Leu Leu Tyr Ala Lys Arg Pro Gly Ile Gly Leu Ser Pro Ser His 
        195                 200                 205             


Arg Arg Tyr Leu Gly Tyr Met Cys Asp Leu Leu Ala Asp Lys Pro Tyr 
    210                 215                 220                 


Arg Pro His Phe Lys Pro Leu Thr Ile Lys Ser Ile Thr Val Ser Pro 
225                 230                 235                 240 


Ile Pro Phe Phe Asn Lys Gln Arg Asn Gly Cys Arg Pro Tyr Cys Asp 
                245                 250                 255     


Val Leu Ile Gly Glu Thr Lys Ile Tyr Ser Thr Cys Thr Asp Phe Glu 
            260                 265                 270         


Arg Met Lys Glu Tyr Arg Val Gln Asp Gly Lys Ile Phe Ile Pro Leu 
        275                 280                 285             


Asn Ile Thr Val Gln Gly Asp Val Val Val Ser Met Tyr His Leu Arg 
    290                 295                 300                 


Ser Thr Ile Gly Ser Arg Leu Gln Ala Lys Val Thr Asn Thr Gln Ile 
305                 310                 315                 320 


Phe Gln Leu Gln Phe His Thr Gly Phe Ile Pro Leu Asp Thr Thr Val 
                325                 330                 335     


Leu Lys Phe Thr Lys Pro Glu Leu Asp Ala Cys Asp Val Pro Glu Lys 
            340                 345                 350         


Tyr Pro Gln Leu Phe Gln Val Thr Leu Asp Val Glu Leu Gln Pro His 
        355                 360                 365             


Asp Lys Val Ile Asp Leu Thr Pro Pro Trp Glu His Tyr Cys Thr Lys 
    370                 375                 380                 


Asp Val Asn Pro Ser Ile Leu Phe Ser Ser His Gln Glu His Gln Asp 
385                 390                 395                 400 


Thr Leu Ala Leu Gly Gly Gln Ala Pro Ile Asp Ile Pro Pro Asp Asn 
                405                 410                 415     


Pro Arg His Tyr Gly Gln Ser Gly Phe Phe Ala Ser Leu Cys Trp Gln 
            420                 425                 430         


Asp Gln Lys Ser Glu Lys Ser Phe Cys Glu Glu Asp His Ala Ala Leu 
        435                 440                 445             


Val Asn Gln Glu Ser Glu Gln Ser Asp Asp Glu Leu Leu Thr Leu Ser 
    450                 455                 460                 


Ser Pro His Gly Asn Ala Asn Gly Asp Lys Pro His Gly Val Lys Lys 
465                 470                 475                 480 


Pro Ser Lys Lys Gln Gln Glu Pro Ala Ala Pro Pro Pro Pro Glu Asp 
                485                 490                 495     


Val Asp Leu Leu Gly Leu Glu Gly Ser Ala Met Ser Asn Ser Phe Ser 
            500                 505                 510         


Pro Pro Ala Ala Pro Pro Thr Asn Ser Glu Leu Leu Ser Asp Leu Phe 
        515                 520                 525             


Gly Gly Gly Gly Ala Ala Gly Pro Thr Gln Ala Gly Gln Ser Gly Val 
    530                 535                 540                 


Glu Asp Val Phe His Pro Ser Gly Pro Ala Ser Thr Gln Ser Thr Pro 
545                 550                 555                 560 


Arg Arg Ser Ala Thr Ser Thr Ser Ala Ser Pro Thr Leu Arg Val Gly 
                565                 570                 575     


Glu Gly Ala Thr Phe Asp Pro Phe Gly Ala Pro Ser Lys Pro Ser Gly 
            580                 585                 590         


Gln Asp Leu Leu Gly Ser Phe Leu Asn Thr Ser Ser Ala Ser Ser Asp 
        595                 600                 605             


Pro Phe Leu Gln Pro Thr Arg Ser Pro Ser Pro Thr Val His Ala Ser 
    610                 615                 620                 


Ser Thr Pro Ala Val Asn Ile Gln Pro Asp Val Ser Gly Gly Trp Asp 
625                 630                 635                 640 


Trp His Ala Lys Pro Gly Gly Phe Gly Met Gly Ser Lys Ser Ala Ala 
                645                 650                 655     


Thr Ser Pro Thr Gly Ser Ser His Gly Thr Pro Thr His Gln Ser Lys 
            660                 665                 670         


Pro Gln Thr Leu Asp Pro Phe Ala Asp Leu Gly Thr Leu Gly Ser Ser 
        675                 680                 685             


Ser Phe Ala Ser Lys Pro Thr Thr Pro Thr Gly Leu Gly Gly Gly Phe 
    690                 695                 700                 


Pro Pro Leu Ser Ser Pro Gln Lys Ala Ser Pro Gln Pro Met Gly Gly 
705                 710                 715                 720 


Gly Trp Gln Gln Gly Gly Ala Tyr Asn Trp Gln Gln Pro Gln Pro Lys 
                725                 730                 735     


Pro Gln Pro Ser Met Pro His Ser Ser Pro Gln Asn Arg Pro Asn Tyr 
            740                 745                 750         


Asn Val Ser Phe Ser Ala Met Pro Gly Gly Gln Asn Glu Arg Gly Lys 
        755                 760                 765             


Gly Ser Ser Asn Leu Glu Gly Lys Gln Lys Ala Ala Asp Phe Glu Asp 
    770                 775                 780                 


Leu Leu Ser Gly Gln Gly Phe Asn Ala His Lys Asp Lys Lys Gly Pro 
785                 790                 795                 800 


Arg Thr Ile Ala Glu Met Arg Lys Glu Glu Met Ala Lys Glu Met Asp 
                805                 810                 815     


Pro Glu Lys Leu Lys Ile Leu Glu Trp Ile Glu Gly Lys Glu Arg Asn 
            820                 825                 830         


Ile Arg Ala Leu Leu Ser Thr Met His Thr Val Leu Trp Ala Gly Glu 
        835                 840                 845             


Thr Lys Trp Lys Pro Val Gly Met Ala Asp Leu Val Thr Pro Glu Gln 
    850                 855                 860                 


Val Lys Lys Val Tyr Arg Lys Ala Val Leu Val Val His Pro Asp Lys 
865                 870                 875                 880 


Ala Thr Gly Gln Pro Tyr Glu Gln Tyr Ala Lys Met Ile Phe Met Glu 
                885                 890                 895     


Leu Asn Asp Ala Trp Ser Glu Phe Glu Asn Gln Gly Gln Lys Pro Leu 
            900                 905                 910         


Tyr 
    


<210>  71
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  71

Met Pro Arg Tyr Gly Ala Ser Leu Arg Gln Ser Cys Pro Arg Ser Gly 
1               5                   10                  15      


Arg Glu Gln Gly Gln Asp Gly Thr Ala Gly Ala Pro Gly Leu Leu Trp 
            20                  25                  30          


Met Gly Leu Val Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala 
        35                  40                  45              


Leu Ser Asp Ser Arg Val Leu Trp Ala Pro Ala Glu Ala His Pro Leu 
    50                  55                  60                  


Ser Pro Gln Gly His Pro Ala Arg Leu His Arg Ile Val Pro Arg Leu 
65                  70                  75                  80  


Arg Asp Val Phe Gly Trp Gly Asn Leu Thr Cys Pro Ile Cys Lys Gly 
                85                  90                  95      


Leu Phe Thr Ala Ile Asn Leu Gly Leu Lys Lys Glu Pro Asn Val Ala 
            100                 105                 110         


Arg Val Gly Ser Val Ala Ile Lys Leu Cys Asn Leu Leu Lys Ile Ala 
        115                 120                 125             


Pro Pro Ala Val Cys Gln Ser Ile Val His Leu Phe Glu Asp Asp Met 
    130                 135                 140                 


Val Glu Val Trp Arg Arg Ser Val Leu Ser Pro Ser Glu Ala Cys Gly 
145                 150                 155                 160 


Leu Leu Leu Gly Ser Thr Cys Gly His Trp Asp Ile Phe Ser Ser Trp 
                165                 170                 175     


Asn Ile Ser Leu Pro Thr Val Pro Lys Pro Pro Pro Lys Pro Pro Ser 
            180                 185                 190         


Pro Pro Ala Pro Gly Ala Pro Val Ser Arg Ile Leu Phe Leu Thr Asp 
        195                 200                 205             


Leu His Trp Asp His Asp Tyr Leu Glu Gly Thr Asp Pro Asp Cys Ala 
    210                 215                 220                 


Asp Pro Leu Cys Cys Arg Arg Gly Ser Gly Leu Pro Pro Ala Ser Arg 
225                 230                 235                 240 


Pro Gly Ala Gly Tyr Trp Gly Glu Tyr Ser Lys Cys Asp Leu Pro Leu 
                245                 250                 255     


Arg Thr Leu Glu Ser Leu Leu Ser Gly Leu Gly Pro Ala Gly Pro Phe 
            260                 265                 270         


Asp Met Val Tyr Trp Thr Gly Asp Ile Pro Ala His Asp Val Trp His 
        275                 280                 285             


Gln Thr Arg Gln Asp Gln Leu Arg Ala Leu Thr Thr Val Thr Ala Leu 
    290                 295                 300                 


Val Arg Lys Phe Leu Gly Pro Val Pro Val Tyr Pro Ala Val Gly Asn 
305                 310                 315                 320 


His Glu Ser Thr Pro Val Asn Ser Phe Pro Pro Pro Phe Ile Glu Gly 
                325                 330                 335     


Asn His Ser Ser Arg Trp Leu Tyr Glu Ala Met Ala Lys Ala Trp Glu 
            340                 345                 350         


Pro Trp Leu Pro Ala Glu Ala Leu Arg Thr Leu Arg Ile Gly Gly Phe 
        355                 360                 365             


Tyr Ala Leu Ser Pro Tyr Pro Gly Leu Arg Leu Ile Ser Leu Asn Met 
    370                 375                 380                 


Asn Phe Cys Ser Arg Glu Asn Phe Trp Leu Leu Ile Asn Ser Thr Asp 
385                 390                 395                 400 


Pro Ala Gly Gln Leu Gln Trp Leu Val Gly Glu Leu Gln Ala Ala Glu 
                405                 410                 415     


Asp Arg Gly Asp Lys Val His Ile Ile Gly His Ile Pro Pro Gly His 
            420                 425                 430         


Cys Leu Lys Ser Trp Ser Trp Asn Tyr Tyr Arg Ile Val Ala Arg Tyr 
        435                 440                 445             


Glu Asn Thr Leu Ala Ala Gln Phe Phe Gly His Thr His Val Asp Glu 
    450                 455                 460                 


Phe Glu Val Phe Tyr Asp Glu Glu Thr Leu Ser Arg Pro Leu Ala Val 
465                 470                 475                 480 


Ala Phe Leu Ala Pro Ser Ala Thr Thr Tyr Ile Gly Leu Asn Pro Gly 
                485                 490                 495     


Tyr Arg Val Tyr Gln Ile Asp Gly Asn Tyr Ser Gly Ser Ser His Val 
            500                 505                 510         


Val Leu Asp His Glu Thr Tyr Ile Leu Asn Leu Thr Gln Ala Asn Ile 
        515                 520                 525             


Pro Gly Ala Ile Pro His Trp Gln Leu Leu Tyr Arg Ala Arg Glu Thr 
    530                 535                 540                 


Tyr Gly Leu Pro Asn Thr Leu Pro Thr Ala Trp His Asn Leu Val Tyr 
545                 550                 555                 560 


Arg Met Arg Gly Asp Met Gln Leu Phe Gln Thr Phe Trp Phe Leu Tyr 
                565                 570                 575     


His Lys Gly His Pro Pro Ser Glu Pro Cys Gly Thr Pro Cys Arg Leu 
            580                 585                 590         


Ala Thr Leu Cys Ala Gln Leu Ser Ala Arg Ala Asp Ser Pro Ala Leu 
        595                 600                 605             


Cys Arg His Leu Met Pro Asp Gly Ser Leu Pro Glu Ala Gln Ser Leu 
    610                 615                 620                 


Trp Pro Arg Pro Leu Phe Cys 
625                 630     


<210>  72
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72

Met Ser Gln Pro Arg Thr Pro Glu Gln Ala Leu Asp Thr Pro Gly Asp 
1               5                   10                  15      


Cys Pro Pro Gly Arg Arg Asp Glu Asp Ala Gly Glu Gly Ile Gln Cys 
            20                  25                  30          


Ser Gln Arg Met Leu Ser Phe Ser Asp Ala Leu Leu Ser Ile Ile Ala 
        35                  40                  45              


Thr Val Met Ile Leu Pro Val Thr His Thr Glu Ile Ser Pro Glu Gln 
    50                  55                  60                  


Gln Phe Asp Arg Ser Val Gln Arg Leu Leu Ala Thr Arg Ile Ala Val 
65                  70                  75                  80  


Tyr Leu Met Thr Phe Leu Ile Val Thr Val Ala Trp Ala Ala His Thr 
                85                  90                  95      


Arg Leu Phe Gln Val Val Gly Lys Thr Asp Asp Thr Leu Ala Leu Leu 
            100                 105                 110         


Asn Leu Ala Cys Met Met Thr Ile Thr Phe Leu Pro Tyr Thr Phe Ser 
        115                 120                 125             


Leu Met Val Thr Phe Pro Asp Val Pro Leu Gly Ile Phe Leu Phe Cys 
    130                 135                 140                 


Val Cys Val Ile Ala Ile Gly Val Val Gln Ala Leu Ile Val Gly Tyr 
145                 150                 155                 160 


Ala Phe His Phe Pro His Leu Leu Ser Pro Gln Ile Gln Arg Ser Ala 
                165                 170                 175     


His Arg Ala Leu Tyr Arg Arg His Val Leu Gly Ile Val Leu Gln Gly 
            180                 185                 190         


Pro Ala Leu Cys Phe Ala Ala Ala Ile Phe Ser Leu Phe Phe Val Pro 
        195                 200                 205             


Leu Ser Tyr Leu Leu Met Val Thr Val Ile Leu Leu Pro Tyr Val Ser 
    210                 215                 220                 


Lys Val Thr Gly Trp Cys Arg Asp Arg Leu Leu Gly His Arg Glu Pro 
225                 230                 235                 240 


Ser Ala His Pro Val Glu Val Phe Ser Phe Asp Leu His Glu Pro Leu 
                245                 250                 255     


Ser Lys Glu Arg Val Glu Ala Phe Ser Asp Gly Val Tyr Ala Ile Val 
            260                 265                 270         


Ala Thr Leu Leu Ile Leu Asp Ile Cys Glu Asp Asn Val Pro Asp Pro 
        275                 280                 285             


Lys Asp Val Lys Glu Arg Phe Ser Gly Ser Leu Val Ala Ala Leu Ser 
    290                 295                 300                 


Ala Thr Gly Pro Arg Phe Leu Ala Tyr Phe Gly Ser Phe Ala Thr Val 
305                 310                 315                 320 


Gly Leu Leu Trp Phe Ala His His Ser Leu Phe Leu His Val Arg Lys 
                325                 330                 335     


Ala Thr Arg Ala Met Gly Leu Leu Asn Thr Leu Ser Leu Ala Phe Val 
            340                 345                 350         


Gly Gly Leu Pro Leu Ala Tyr Gln Gln Thr Ser Ala Phe Ala Arg Gln 
        355                 360                 365             


Pro Arg Asp Glu Leu Glu Arg Val Arg Val Ser Cys Thr Ile Ile Phe 
    370                 375                 380                 


Leu Ala Ser Ile Phe Gln Leu Ala Met Trp Thr Thr Ala Leu Leu His 
385                 390                 395                 400 


Gln Ala Glu Thr Leu Gln Pro Ser Val Trp Phe Gly Gly Arg Glu His 
                405                 410                 415     


Val Leu Met Phe Ala Lys Leu Ala Leu Tyr Pro Cys Ala Ser Leu Leu 
            420                 425                 430         


Ala Phe Ala Ser Thr Cys Leu Leu Ser Arg Phe Ser Val Gly Ile Phe 
        435                 440                 445             


His Leu Met Gln Ile Ala Val Pro Cys Ala Phe Leu Leu Leu Arg Leu 
    450                 455                 460                 


Leu Val Gly Leu Ala Leu Ala Thr Leu Arg Val Leu Arg Gly Leu Ala 
465                 470                 475                 480 


Arg Pro Glu His Pro Pro Pro Ala Pro Thr Gly Gln Asp Asp Pro Gln 
                485                 490                 495     


Ser Gln Leu Leu Pro Ala Pro Cys 
            500                 


<210>  73
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  73

Met Ala Glu Pro Ser Gly Ser Pro Val His Val Gln Leu Pro Gln Gln 
1               5                   10                  15      


Ala Ala Pro Val Thr Ala Ala Ala Ala Ala Ala Pro Ala Ala Ala Thr 
            20                  25                  30          


Ala Ala Pro Ala Pro Ala Ala Pro Ala Ala Pro Ala Pro Ala Pro Ala 
        35                  40                  45              


Pro Ala Ala Gln Ala Val Gly Trp Pro Ile Cys Arg Asp Ala Tyr Glu 
    50                  55                  60                  


Leu Gln Glu Val Ile Gly Ser Gly Ala Thr Ala Val Val Gln Ala Ala 
65                  70                  75                  80  


Leu Cys Lys Pro Arg Gln Glu Arg Val Ala Ile Lys Arg Ile Asn Leu 
                85                  90                  95      


Glu Lys Cys Gln Thr Ser Met Asp Glu Leu Leu Lys Glu Ile Gln Ala 
            100                 105                 110         


Met Ser Gln Cys Ser His Pro Asn Val Val Thr Tyr Tyr Thr Ser Phe 
        115                 120                 125             


Val Val Lys Asp Glu Leu Trp Leu Val Met Lys Leu Leu Ser Gly Gly 
    130                 135                 140                 


Ser Met Leu Asp Ile Ile Lys Tyr Ile Val Asn Arg Gly Glu His Lys 
145                 150                 155                 160 


Asn Gly Val Leu Glu Glu Ala Ile Ile Ala Thr Ile Leu Lys Glu Val 
                165                 170                 175     


Leu Glu Gly Leu Asp Tyr Leu His Arg Asn Gly Gln Ile His Arg Asp 
            180                 185                 190         


Leu Lys Ala Gly Asn Ile Leu Leu Gly Glu Asp Gly Ser Val Gln Ile 
        195                 200                 205             


Ala Asp Phe Gly Val Ser Ala Phe Leu Ala Thr Gly Gly Asp Val Thr 
    210                 215                 220                 


Arg Asn Lys Val Arg Lys Thr Phe Val Gly Thr Pro Cys Trp Met Ala 
225                 230                 235                 240 


Pro Glu Val Met Glu Gln Val Arg Gly Tyr Asp Phe Lys Ala Asp Met 
                245                 250                 255     


Trp Ser Phe Gly Ile Thr Ala Ile Glu Leu Ala Thr Gly Ala Ala Pro 
            260                 265                 270         


Tyr His Lys Tyr Pro Pro Met Lys Val Leu Met Leu Thr Leu Gln Asn 
        275                 280                 285             


Asp Pro Pro Thr Leu Glu Thr Gly Val Glu Asp Lys Glu Met Met Lys 
    290                 295                 300                 


Lys Tyr Gly Lys Ser Phe Arg Lys Leu Leu Ser Leu Cys Leu Gln Lys 
305                 310                 315                 320 


Asp Pro Ser Lys Arg Pro Thr Ala Ala Glu Leu Leu Lys Cys Lys Phe 
                325                 330                 335     


Phe Gln Lys Ala Lys Asn Arg Glu Tyr Leu Ile Glu Lys Leu Leu Thr 
            340                 345                 350         


Arg Thr Pro Asp Ile Ala Gln Arg Ala Lys Lys Val Arg Arg Val Pro 
        355                 360                 365             


Gly Ser Ser Gly His Leu His Lys Thr Glu Asp Gly Asp Trp Glu Trp 
    370                 375                 380                 


Ser Asp Asp Glu Met Asp Glu Lys Ser Glu Glu Gly Lys Ala Ala Phe 
385                 390                 395                 400 


Ser Gln Glu Lys Ser Arg Arg Val Lys Glu Glu Asn Pro Glu Ile Ala 
                405                 410                 415     


Val Ser Ala Ser Thr Ile Pro Glu Gln Ile Gln Ser Leu Ser Val His 
            420                 425                 430         


Asp Ser Gln Gly Pro Pro Asn Ala Asn Glu Asp Tyr Arg Glu Ala Ser 
        435                 440                 445             


Ser Cys Ala Val Asn Leu Val Leu Arg Leu Arg Asn Ser Arg Lys Glu 
    450                 455                 460                 


Leu Asn Asp Ile Arg Phe Glu Phe Thr Pro Gly Arg Asp Thr Ala Asp 
465                 470                 475                 480 


Gly Val Ser Gln Glu Leu Phe Ser Ala Gly Leu Val Asp Gly His Asp 
                485                 490                 495     


Val Val Ile Val Ala Ala Asn Leu Gln Lys Ile Val Asp Asp Pro Lys 
            500                 505                 510         


Ala Leu Lys Thr Leu Thr Phe Lys Leu Ala Ser Gly Cys Asp Gly Ser 
        515                 520                 525             


Glu Ile Pro Asp Glu Val Lys Leu Ile Gly Phe Ala Gln Leu Ser Val 
    530                 535                 540                 


Ser 
545 


<210>  74
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  74

Met Ala Ala Gln Gly Cys Ala Ala Ser Arg Leu Leu Gln Leu Leu Leu 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Leu Leu Ala Ala Gly Gly Ala Arg Ala 
            20                  25                  30          


Arg Trp Arg Gly Glu Gly Thr Ser Ala His Leu Arg Asp Ile Phe Leu 
        35                  40                  45              


Gly Arg Cys Ala Glu Tyr Arg Ala Leu Leu Ser Pro Glu Gln Arg Asn 
    50                  55                  60                  


Lys Asn Cys Thr Ala Ile Trp Glu Ala Phe Lys Val Ala Leu Asp Lys 
65                  70                  75                  80  


Asp Pro Cys Ser Val Leu Pro Ser Asp Tyr Asp Leu Phe Ile Asn Leu 
                85                  90                  95      


Ser Arg His Ser Ile Pro Arg Asp Lys Ser Leu Phe Trp Glu Asn Ser 
            100                 105                 110         


His Leu Leu Val Asn Ser Phe Ala Asp Asn Thr Arg Arg Phe Met Pro 
        115                 120                 125             


Leu Ser Asp Val Leu Tyr Gly Arg Val Ala Asp Phe Leu Ser Trp Cys 
    130                 135                 140                 


Arg Gln Lys Asn Asp Ser Gly Leu Asp Tyr Gln Ser Cys Pro Thr Ser 
145                 150                 155                 160 


Glu Asp Cys Glu Asn Asn Pro Val Asp Ser Phe Trp Lys Arg Ala Ser 
                165                 170                 175     


Ile Gln Tyr Ser Lys Asp Ser Ser Gly Val Ile His Val Met Leu Asn 
            180                 185                 190         


Gly Ser Glu Pro Thr Gly Ala Tyr Pro Ile Lys Gly Phe Phe Ala Asp 
        195                 200                 205             


Tyr Glu Ile Pro Asn Leu Gln Lys Glu Lys Ile Thr Arg Ile Glu Ile 
    210                 215                 220                 


Trp Val Met His Glu Ile Gly Gly Pro Asn Val Glu Ser Cys Gly Glu 
225                 230                 235                 240 


Gly Ser Met Lys Val Leu Glu Lys Arg Leu Lys Asp Met Gly Phe Gln 
                245                 250                 255     


Tyr Ser Cys Ile Asn Asp Tyr Arg Pro Val Lys Leu Leu Gln Cys Val 
            260                 265                 270         


Asp His Ser Thr His Pro Asp Cys Ala Leu Lys Ser Ala Ala Ala Ala 
        275                 280                 285             


Thr Gln Arg Lys Ala Pro Ser Leu Tyr Thr Glu Gln Arg Ala Gly Leu 
    290                 295                 300                 


Ile Ile Pro Leu Phe Leu Val Leu Ala Ser Arg Thr Gln Leu 
305                 310                 315             


<210>  75
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  75

Met Ile Leu Leu Thr Phe Ser Thr Gly Arg Arg Leu Asp Phe Val His 
1               5                   10                  15      


His Ser Gly Val Phe Phe Leu Gln Thr Leu Leu Trp Ile Leu Cys Ala 
            20                  25                  30          


Thr Val Cys Gly Thr Glu Gln Tyr Phe Asn Val Glu Val Trp Leu Gln 
        35                  40                  45              


Lys Tyr Gly Tyr Leu Pro Pro Thr Asp Pro Arg Met Ser Val Leu Arg 
    50                  55                  60                  


Ser Ala Glu Thr Met Gln Ser Ala Leu Ala Ala Met Gln Gln Phe Tyr 
65                  70                  75                  80  


Gly Ile Asn Met Thr Gly Lys Val Asp Arg Asn Thr Ile Asp Trp Met 
                85                  90                  95      


Lys Lys Pro Arg Cys Gly Val Pro Asp Gln Thr Arg Gly Ser Ser Lys 
            100                 105                 110         


Phe His Ile Arg Arg Lys Arg Tyr Ala Leu Thr Gly Gln Lys Trp Gln 
        115                 120                 125             


His Lys His Ile Thr Tyr Ser Ile Lys Asn Val Thr Pro Lys Val Gly 
    130                 135                 140                 


Asp Pro Glu Thr Arg Lys Ala Ile Arg Arg Ala Phe Asp Val Trp Gln 
145                 150                 155                 160 


Asn Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr Ser Glu Leu Glu 
                165                 170                 175     


Asn Gly Lys Arg Asp Val Asp Ile Thr Ile Ile Phe Ala Ser Gly Phe 
            180                 185                 190         


His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly Phe Leu Ala His 
        195                 200                 205             


Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr His Phe Asp Ser 
    210                 215                 220                 


Asp Glu Pro Trp Thr Leu Gly Asn Pro Asn His Asp Gly Asn Asp Leu 
225                 230                 235                 240 


Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His 
                245                 250                 255     


Ser Asn Asp Pro Thr Ala Ile Met Ala Pro Phe Tyr Gln Tyr Met Glu 
            260                 265                 270         


Thr Asp Asn Phe Lys Leu Pro Asn Asp Asp Leu Gln Gly Ile Gln Lys 
        275                 280                 285             


Ile Tyr Gly Pro Pro Asp Lys Ile Pro Pro Pro Thr Arg Pro Leu Pro 
    290                 295                 300                 


Thr Val Pro Pro His Arg Ser Ile Pro Pro Ala Asp Pro Arg Lys Asn 
305                 310                 315                 320 


Asp Arg Pro Lys Pro Pro Arg Pro Pro Thr Gly Arg Pro Ser Tyr Pro 
                325                 330                 335     


Gly Ala Lys Pro Asn Ile Cys Asp Gly Asn Phe Asn Thr Leu Ala Ile 
            340                 345                 350         


Leu Arg Arg Glu Met Phe Val Phe Lys Asp Gln Trp Phe Trp Arg Val 
        355                 360                 365             


Arg Asn Asn Arg Val Met Asp Gly Tyr Pro Met Gln Ile Thr Tyr Phe 
    370                 375                 380                 


Trp Arg Gly Leu Pro Pro Ser Ile Asp Ala Val Tyr Glu Asn Ser Asp 
385                 390                 395                 400 


Gly Asn Phe Val Phe Phe Lys Gly Asn Lys Tyr Trp Val Phe Lys Asp 
                405                 410                 415     


Thr Thr Leu Gln Pro Gly Tyr Pro His Asp Leu Ile Thr Leu Gly Ser 
            420                 425                 430         


Gly Ile Pro Pro His Gly Ile Asp Ser Ala Ile Trp Trp Glu Asp Val 
        435                 440                 445             


Gly Lys Thr Tyr Phe Phe Lys Gly Asp Arg Tyr Trp Arg Tyr Ser Glu 
    450                 455                 460                 


Glu Met Lys Thr Met Asp Pro Gly Tyr Pro Lys Pro Ile Thr Val Trp 
465                 470                 475                 480 


Lys Gly Ile Pro Glu Ser Pro Gln Gly Ala Phe Val His Lys Glu Asn 
                485                 490                 495     


Gly Phe Thr Tyr Phe Tyr Lys Gly Lys Glu Tyr Trp Lys Phe Asn Asn 
            500                 505                 510         


Gln Ile Leu Lys Val Glu Pro Gly Tyr Pro Arg Ser Ile Leu Lys Asp 
        515                 520                 525             


Phe Met Gly Cys Asp Gly Pro Thr Asp Arg Val Lys Glu Gly His Ser 
    530                 535                 540                 


Pro Pro Asp Asp Val Asp Ile Val Ile Lys Leu Asp Asn Thr Ala Ser 
545                 550                 555                 560 


Thr Val Lys Ala Ile Ala Ile Val Ile Pro Cys Ile Leu Ala Leu Cys 
                565                 570                 575     


Leu Leu Val Leu Val Tyr Thr Val Phe Gln Phe Lys Arg Lys Gly Thr 
            580                 585                 590         


Pro Arg His Ile Leu Tyr Cys Lys Arg Ser Met Gln Glu Trp Val 
        595                 600                 605         


<210>  76
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  76

Met Glu Val Glu Asn Glu Ala Ser Cys Ser Pro Gly Ser Ala Ser Gly 
1               5                   10                  15      


Gly Ser Arg Glu Tyr Lys Val Val Met Leu Gly Ala Gly Gly Val Gly 
            20                  25                  30          


Lys Ser Ala Met Thr Met Gln Phe Ile Ser His Gln Phe Pro Asp Tyr 
        35                  40                  45              


His Asp Pro Thr Ile Glu Asp Ala Tyr Lys Thr Gln Val Arg Ile Asp 
    50                  55                  60                  


Asn Glu Pro Ala Tyr Leu Asp Ile Leu Asp Thr Ala Gly Gln Ala Glu 
65                  70                  75                  80  


Phe Thr Ala Met Arg Glu Gln Tyr Met Arg Gly Gly Glu Gly Phe Ile 
                85                  90                  95      


Ile Cys Tyr Ser Val Thr Asp Arg Gln Ser Phe Gln Glu Ala Ala Lys 
            100                 105                 110         


Phe Lys Glu Leu Ile Phe Gln Val Arg His Thr Tyr Glu Ile Pro Leu 
        115                 120                 125             


Val Leu Val Gly Asn Lys Ile Asp Leu Glu Gln Phe Arg Gln Val Ser 
    130                 135                 140                 


Thr Glu Glu Gly Leu Ser Leu Ala Gln Glu Tyr Asn Cys Gly Phe Phe 
145                 150                 155                 160 


Glu Thr Ser Ala Ala Leu Arg Phe Cys Ile Asp Asp Ala Phe His Gly 
                165                 170                 175     


Leu Val Arg Glu Ile Arg Lys Lys Glu Ser Met Pro Ser Leu Met Glu 
            180                 185                 190         


Lys Lys Leu Lys Arg Lys Asp Ser Leu Trp Lys Lys Leu Lys Gly Ser 
        195                 200                 205             


Leu Lys Lys Lys Arg Glu Asn Met Thr 
    210                 215         


<210>  77
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  77

Met Ala Asp Arg Arg Arg Arg Leu Arg Pro Gly Thr Leu Ala Pro Val 
1               5                   10                  15      


Arg Glu Gly Val Asn Cys Arg Ser Arg Cys Phe Thr Lys His Lys Asn 
            20                  25                  30          


Gly Leu Lys Phe Pro Thr Ser Leu His Ser Arg Gln Leu Val Phe Pro 
        35                  40                  45              


Arg Lys Gly Leu Asp Asp Phe Arg Lys Gly Cys Pro Pro Cys Thr Gly 
    50                  55                  60                  


Leu Val Thr Gln Val Pro Val Glu Gly Phe Leu Pro Gln Ile Tyr His 
65                  70                  75                  80  


Arg Ala Pro Gln Leu Ala Pro Lys Lys Arg Gln Ile Lys Leu Leu Lys 
                85                  90                  95      


Glu Ala Asp Val Leu Ser Lys Leu Ser Pro Ala Gln Gln Ala Arg Lys 
            100                 105                 110         


Ala Phe Leu Glu Asp Val Glu Ala His Leu Thr Pro His Pro Leu Ala 
        115                 120                 125             


Leu Tyr Leu Asn Leu Glu Glu Ala Met Pro Ile Glu Leu Leu Ser Lys 
    130                 135                 140                 


Val Leu Glu Val Leu Asp Pro Asp Arg Lys Leu Glu Asp Thr Trp Ala 
145                 150                 155                 160 


Tyr Cys Gln Asp Thr Arg Lys Gly Met Lys Glu Pro Thr Lys Leu Leu 
                165                 170                 175     


Lys Lys His Ser Thr Gln Val Tyr Leu Gly Pro Ser Lys Lys Thr Ser 
            180                 185                 190         


Val Ser Asn Ala Gly Gln Trp Leu Tyr Glu Glu Lys Pro His Lys Met 
        195                 200                 205             


Asp Leu Leu His Glu Asn Gly Pro Arg Pro Gly Leu His Glu Asn Gly 
    210                 215                 220                 


Ile Ser Asp Ile Asp Glu Glu Phe Ile Leu Lys Gln Phe Asp Ile Asp 
225                 230                 235                 240 


Tyr Glu Thr Lys Pro Ser His Asp Ala Leu His Thr Met Lys Leu Asn 
                245                 250                 255     


Gln Val Pro Leu Glu Leu Lys Arg Ser Val Gly Leu Ser Lys Leu Gln 
            260                 265                 270         


Glu Thr Glu Phe Phe Gln Lys Leu Gly Tyr Glu Arg Lys Leu Gln Lys 
        275                 280                 285             


Pro Gln Asn Pro Tyr Lys Pro Lys Trp Val Lys Met Arg Tyr Gly Ala 
    290                 295                 300                 


Trp Tyr Leu Asn Pro Lys Leu Trp Lys Lys Gln Arg Val Asp Glu Pro 
305                 310                 315                 320 


Leu Val Asp Pro Glu Val Ser His Lys Ala Gln Glu Glu Asn Phe Lys 
                325                 330                 335     


Lys Glu Leu Gln Glu Gln Glu Glu Leu Leu Ala Asp Leu His Gly Thr 
            340                 345                 350         


Val Ala Phe Lys Asp Phe Ile Leu Ser Arg Gly Tyr Arg Thr Pro Arg 
        355                 360                 365             


Phe Leu Glu Asn Met Tyr Ile Gly Lys Glu Cys Lys Arg Ala Cys Asn 
    370                 375                 380                 


Lys Thr Pro Ile Lys Arg Thr Gln Ala 
385                 390             


<210>  78
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  78

Met Asn Pro Pro Ala Ala Phe Leu Ala Gly Arg Gln Asn Ile Gly Ser 
1               5                   10                  15      


Glu Val Glu Ile Ser Thr Ile Glu Lys Gln Arg Lys Glu Leu Gln Leu 
            20                  25                  30          


Leu Ile Gly Glu Leu Lys Asp Arg Asp Lys Glu Leu Asn Asp Met Val 
        35                  40                  45              


Ala Val His Gln Gln Gln Leu Leu Ser Trp Glu Glu Asp Arg Gln Lys 
    50                  55                  60                  


Val Leu Thr Leu Glu Glu Arg Cys Ser Lys Leu Glu Gly Glu Leu His 
65                  70                  75                  80  


Lys Arg Thr Glu Ile Ile Arg Ser Leu Thr Lys Lys Val Lys Ala Leu 
                85                  90                  95      


Glu Ser Asn Gln Met Glu Cys Gln Thr Ala Leu Gln Lys Thr Gln Leu 
            100                 105                 110         


Gln Leu Gln Glu Met Ala Gln Lys Ala Thr His Ser Ser Leu Leu Ser 
        115                 120                 125             


Glu Asp Leu Glu Ala Arg Asn Glu Thr Leu Ser Asn Thr Leu Val Glu 
    130                 135                 140                 


Leu Ser Ala Gln Val Gly Gln Leu Gln Ala Arg Glu Gln Ala Leu Thr 
145                 150                 155                 160 


Thr Met Ile Lys Leu Lys Asp Lys Asp Ile Ile Glu Ala Val Asn His 
                165                 170                 175     


Ile Ala Asp Cys Ser Gly Lys Phe Lys Met Leu Glu His Ala Leu Arg 
            180                 185                 190         


Asp Ala Lys Met Ala Glu Thr Cys Ile Val Lys Glu Lys Gln Asp Tyr 
        195                 200                 205             


Lys Gln Lys Leu Lys Ala Leu Lys Ile Glu Val Asn Lys Leu Lys Glu 
    210                 215                 220                 


Asp Leu Asn Glu Lys Thr Thr Glu Asn Asn Glu Gln Arg Glu Glu Ile 
225                 230                 235                 240 


Ile Arg Leu Lys Gln Glu Lys Ser Cys Leu His Asp Glu Leu Leu Phe 
                245                 250                 255     


Thr Val Glu Arg Glu Lys Arg Lys Asp Glu Leu Leu Asn Ile Ala Lys 
            260                 265                 270         


Ser Lys Gln Glu Arg Thr Asn Ser Glu Leu His Asn Leu Arg Gln Ile 
        275                 280                 285             


Tyr Val Lys Gln Gln Ser Asp Leu Gln Phe Leu Asn Phe Asn Val Glu 
    290                 295                 300                 


Asn Ser Gln Glu Leu Ile Gln Met Tyr Asp Ser Lys Met Glu Glu Ser 
305                 310                 315                 320 


Lys Ala Leu Asp Ser Ser Arg Asp Met Cys Leu Ser Asp Leu Glu Asn 
                325                 330                 335     


Asn His Pro Lys Val Asp Ile Lys Arg Glu Lys Asn Gln Lys Ser Leu 
            340                 345                 350         


Phe Lys Asp Gln Lys Phe Glu Ala Met Leu Val Gln Gln Asn Arg Ser 
        355                 360                 365             


Asp Lys Ser Ser Cys Asp Glu Cys Lys Glu Lys Lys Gln Gln Ile Asp 
    370                 375                 380                 


Thr Val Phe Gly Glu Lys Ser Val Ile Thr Leu Ser Ser Ile Phe Thr 
385                 390                 395                 400 


Lys Asp Leu Val Glu Lys His Asn Leu Pro Trp Ser Leu Gly Gly Lys 
                405                 410                 415     


Thr Gln Ile Glu Pro Glu Asn Lys Ile Thr Leu Cys Lys Ile His Thr 
            420                 425                 430         


Lys Ser Pro Lys Cys His Gly Thr Gly Val Gln Asn Glu Gly Lys Gln 
        435                 440                 445             


Pro Ser Glu Thr Pro Thr Leu Ser Asp Glu Lys Gln Trp His Asp Val 
    450                 455                 460                 


Ser Val Tyr Leu Gly Leu Thr Asn Cys Pro Ser Ser Lys His Pro Glu 
465                 470                 475                 480 


Lys Leu Asp Val Glu Cys Gln Asp Gln Met Glu Arg Ser Glu Ile Ser 
                485                 490                 495     


Cys Cys Gln Lys Asn Glu Ala Cys Leu Gly Glu Ser Gly Met Cys Asp 
            500                 505                 510         


Ser Lys Cys Cys His Pro Ser Asn Phe Ile Ile Glu Ala Pro Gly His 
        515                 520                 525             


Met Ser Asp Val Glu Trp Met Ser Ile Phe Lys Pro Ser Lys Met Gln 
    530                 535                 540                 


Arg Ile Val Arg Leu Lys Ser Gly Cys Thr Cys Ser Glu Ser Ile Cys 
545                 550                 555                 560 


Gly Thr Gln His Asp Ser Pro Ala Ser Glu Leu Ile Ala Ile Gln Asp 
                565                 570                 575     


Ser His Ser Leu Gly Ser Ser Lys Ser Ala Leu Arg Glu Asp Glu Thr 
            580                 585                 590         


Glu Ser Ser Ser Asn Lys Lys Asn Ser Pro Thr Ser Leu Leu Ile Tyr 
        595                 600                 605             


Lys Asp Ala Pro Ala Phe Asn Glu Lys Ala Ser Ile Val Leu Pro Ser 
    610                 615                 620                 


Gln Asp Asp Phe Ser Pro Thr Ser Lys Leu Gln Arg Leu Leu Ala Glu 
625                 630                 635                 640 


Ser Arg Gln Met Val Thr Asp Leu Glu Leu Ser Thr Leu Leu Pro Ile 
                645                 650                 655     


Ser His Glu Asn Leu Thr Gly Ser Ala Thr Asn Lys Ser Glu Val Pro 
            660                 665                 670         


Glu Glu Ser Ala Gln Lys Asn Thr Phe Val Ser Tyr 
        675                 680                 


<210>  79
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  79

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Ala Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Ala Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Tyr Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Glu Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Pro Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln His Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  80
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  80

Met Ala Ser Ala Glu Pro Leu Thr Ala Leu Ser Arg Trp Tyr Leu Tyr 
1               5                   10                  15      


Ala Ile His Gly Tyr Phe Cys Glu Val Met Phe Thr Ala Ala Trp Glu 
            20                  25                  30          


Phe Val Val Asn Leu Asn Trp Lys Phe Pro Gly Val Thr Ser Val Trp 
        35                  40                  45              


Ala Leu Phe Ile Tyr Gly Thr Ser Ile Leu Ile Val Glu Arg Met Tyr 
    50                  55                  60                  


Leu Arg Leu Arg Gly Arg Cys Pro Leu Leu Leu Arg Cys Leu Ile Tyr 
65                  70                  75                  80  


Thr Leu Trp Thr Tyr Leu Trp Glu Phe Thr Thr Gly Phe Ile Leu Arg 
                85                  90                  95      


Gln Phe Asn Ala Cys Pro Trp Asp Tyr Ser Gln Phe Asp Phe Asp Phe 
            100                 105                 110         


Met Gly Leu Ile Thr Leu Glu Tyr Ala Val Pro Trp Phe Cys Gly Ala 
        115                 120                 125             


Leu Ile Met Glu Gln Phe Ile Ile Arg Asn Thr Leu Arg Leu Arg Phe 
    130                 135                 140                 


Asp Lys Asp Ala Glu Pro Gly Glu Pro Ser Gly Ala Leu Ala Leu Ala 
145                 150                 155                 160 


Asn Gly His Val Lys Thr Asp 
                165         


<210>  81
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  81

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Glu Pro Glu Ser 
        115                 120                 125             


Gly Lys Val Val Gln Glu Gly Phe Leu Arg Glu Pro Gly Pro Pro Gly 
    130                 135                 140                 


Leu Ser His Gln Leu Met Ser Gly Met Pro Gly Ala Pro Leu Leu Pro 
145                 150                 155                 160 


Glu Gly Pro Arg Glu Ala Thr Arg Gln Pro Ser Gly Thr Gly Pro Glu 
                165                 170                 175     


Asp Thr Glu Gly Gly Arg His Ala Pro Glu Leu Leu Lys His Gln Leu 
            180                 185                 190         


Leu Gly Asp Leu His Gln Glu Gly Pro Pro Leu Lys Gly Ala Gly Gly 
        195                 200                 205             


Lys Glu Arg Pro Gly Ser Lys Glu Glu Val Asp Glu Asp Arg Asp Val 
    210                 215                 220                 


Asp Glu Ser Ser Pro Gln Asp Ser Pro Pro Ser Lys Ala Ser Pro Ala 
225                 230                 235                 240 


Gln Asp Gly Arg Pro Pro Gln Thr Ala Ala Arg Glu Ala Thr Ser Ile 
                245                 250                 255     


Pro Gly Phe Pro Ala Glu Gly Ala Ile Pro Leu Pro Val Asp Phe Leu 
            260                 265                 270         


Ser Lys Val Ser Thr Glu Ile Pro Ala Ser Glu Pro Asp Gly Pro Ser 
        275                 280                 285             


Val Gly Arg Ala Lys Gly Gln Asp Ala Pro Leu Glu Phe Thr Phe His 
    290                 295                 300                 


Val Glu Ile Thr Pro Asn Val Gln Lys Glu Gln Ala His Ser Glu Glu 
305                 310                 315                 320 


His Leu Gly Arg Ala Ala Phe Pro Gly Ala Pro Gly Glu Gly Pro Glu 
                325                 330                 335     


Ala Arg Gly Pro Ser Leu Gly Glu Asp Thr Lys Glu Ala Asp Leu Pro 
            340                 345                 350         


Glu Pro Ser Glu Lys Gln Pro Ala Ala Ala Pro Arg Gly Lys Pro Val 
        355                 360                 365             


Ser Arg Val Pro Gln Leu Lys Ala Arg Met Val Ser Lys Ser Lys Asp 
    370                 375                 380                 


Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Thr Ser Thr Arg Ser Ser 
385                 390                 395                 400 


Ala Lys Thr Leu Lys Asn Arg Pro Cys Leu Ser Pro Lys His Pro Thr 
                405                 410                 415     


Pro Gly Ser Ser Asp Pro Leu Ile Gln Pro Ser Ser Pro Ala Val Cys 
            420                 425                 430         


Pro Glu Pro Pro Ser Ser Pro Lys Tyr Val Ser Ser Val Thr Ser Arg 
        435                 440                 445             


Thr Gly Ser Ser Gly Ala Lys Glu Met Lys Leu Lys Gly Ala Asp Gly 
    450                 455                 460                 


Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys 
465                 470                 475                 480 


Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro 
                485                 490                 495     


Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser 
            500                 505                 510         


Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg 
        515                 520                 525             


Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala 
    530                 535                 540                 


Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu 
545                 550                 555                 560 


Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
                565                 570                 575     


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            580                 585                 590         


Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys 
        595                 600                 605             


Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln 
    610                 615                 620                 


Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly 
625                 630                 635                 640 


Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val 
                645                 650                 655     


Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly 
            660                 665                 670         


Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile 
        675                 680                 685             


Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp 
    690                 695                 700                 


His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr 
705                 710                 715                 720 


Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met 
                725                 730                 735     


Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser 
            740                 745                 750         


Leu Ala Lys Gln Gly Leu 
        755             


<210>  82
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  82

Met Ala Ala Ala Val Ala Ala Ala Leu Ala Arg Leu Leu Ala Ala Phe 
1               5                   10                  15      


Leu Leu Leu Ala Ala Gln Val Ala Cys Glu Tyr Gly Met Val His Val 
            20                  25                  30          


Val Ser Gln Ala Gly Gly Pro Glu Gly Lys Asp Tyr Cys Ile Leu Tyr 
        35                  40                  45              


Asn Pro Gln Trp Ala His Leu Pro His Asp Leu Ser Lys Ala Ser Phe 
    50                  55                  60                  


Leu Gln Leu Arg Asn Trp Thr Ala Ser Leu Leu Cys Ser Ala Ala Asp 
65                  70                  75                  80  


Leu Pro Ala Arg Gly Phe Ser Asn Gln Ile Pro Leu Val Ala Arg Gly 
                85                  90                  95      


Asn Cys Thr Phe Tyr Glu Lys Val Arg Leu Ala Gln Gly Ser Gly Ala 
            100                 105                 110         


Arg Gly Leu Leu Ile Val Ser Arg Glu Arg Leu Val Pro Pro Gly Gly 
        115                 120                 125             


Asn Lys Thr Gln Tyr Asp Glu Ile Gly Ile Pro Val Ala Leu Leu Ser 
    130                 135                 140                 


Tyr Lys Asp Met Leu Asp Ile Phe Thr Arg Phe Gly Arg Thr Val Arg 
145                 150                 155                 160 


Ala Ala Leu Tyr Ala Pro Lys Glu Pro Val Leu Asp Tyr Asn Met Val 
                165                 170                 175     


Ile Ile Phe Ile Met Ala Val Gly Thr Val Ala Ile Gly Gly Tyr Trp 
            180                 185                 190         


Ala Gly Ser Arg Asp Val Lys Lys Arg Tyr Met Lys His Lys Arg Asp 
        195                 200                 205             


Asp Gly Pro Glu Lys Gln Glu Asp Glu Ala Val Asp Val Thr Pro Val 
    210                 215                 220                 


Met Thr Cys Val Phe Val Val Met Cys Cys Ser Met Leu Val Leu Leu 
225                 230                 235                 240 


Tyr Tyr Phe Tyr Asp Leu Leu Val Tyr Val Val Ile Gly Ile Phe Cys 
                245                 250                 255     


Leu Ala Ser Ala Thr Gly Leu Tyr Ser Cys Leu Ala Pro Cys Val Arg 
            260                 265                 270         


Arg Leu Pro Phe Gly Lys Cys Arg Ile Pro Asn Asn Ser Leu Pro Tyr 
        275                 280                 285             


Phe His Lys Arg Pro Gln Ala Arg Met Leu Leu Leu Ala Leu Phe Cys 
    290                 295                 300                 


Val Ala Val Ser Val Val Trp Gly Val Phe Arg Asn Glu Asp Gln Trp 
305                 310                 315                 320 


Ala Trp Val Leu Gln Asp Ala Leu Gly Ile Ala Phe Cys Leu Tyr Met 
                325                 330                 335     


Leu Lys Thr Ile Arg Leu Pro Thr Phe Lys Ala Cys Thr Leu Leu Leu 
            340                 345                 350         


Leu Val Leu Phe Leu Tyr Asp Ile Phe Phe Val Phe Ile Thr Pro Phe 
        355                 360                 365             


Leu Thr Lys Ser Gly Ser Ser Ile Met Val Glu Val Ala Thr Gly Pro 
    370                 375                 380                 


Ser Asp Ser Ala Thr Arg Glu Lys Leu Pro Met Val Leu Lys Val Pro 
385                 390                 395                 400 


Arg Leu Asn Ser Ser Pro Leu Ala Leu Cys Asp Arg Pro Phe Ser Leu 
                405                 410                 415     


Leu Gly Phe Gly Asp Ile Leu Val Pro Gly Leu Leu Val Ala Tyr Cys 
            420                 425                 430         


His Arg Phe Asp Ile Gln Val Gln Ser Ser Arg Val Tyr Phe Val Ala 
        435                 440                 445             


Cys Thr Ile Ala Tyr Gly Val Gly Leu Leu Val Thr Phe Val Ala Leu 
    450                 455                 460                 


Ala Leu Met Gln Arg Gly Gln Pro Ala Leu Leu Tyr Leu Val Pro Cys 
465                 470                 475                 480 


Thr Leu Val Thr Ser Cys Ala Val Ala Leu Trp Arg Arg Glu Leu Gly 
                485                 490                 495     


Val Phe Trp Thr Gly Ser Gly Phe Ala Lys Val Leu Pro Pro Ser Pro 
            500                 505                 510         


Trp Ala Pro Ala Pro Ala Asp Gly Pro Gln Pro Pro Lys Asp Ser Ala 
        515                 520                 525             


Thr Pro Leu Ser Pro Gln Pro Pro Ser Glu Glu Pro Ala Thr Ser Pro 
    530                 535                 540                 


Trp Pro Ala Glu Gln Ser Pro Lys Ser Arg Thr Ser Glu Glu Met Gly 
545                 550                 555                 560 


Ala Gly Ala Pro Met Arg Glu Pro Gly Ser Pro Ala Glu Ser Glu Gly 
                565                 570                 575     


Arg Asp Gln Ala Gln Pro Ser Pro Val Thr Gln Pro Gly Ala Ser Ala 
            580                 585                 590         


<210>  83
<211>  1063
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  83

Met Ser Pro Gly Ala Ser Arg Gly Pro Arg Gly Ser Gln Ala Pro Leu 
1               5                   10                  15      


Ile Ala Pro Leu Cys Cys Ala Ala Ala Ala Leu Gly Met Leu Leu Trp 
            20                  25                  30          


Ser Pro Ala Cys Gln Ala Phe Asn Leu Asp Val Glu Lys Leu Thr Val 
        35                  40                  45              


Tyr Ser Gly Pro Lys Gly Ser Tyr Phe Gly Tyr Ala Val Asp Phe His 
    50                  55                  60                  


Ile Pro Asp Ala Arg Thr Ala Ser Val Leu Val Gly Ala Pro Lys Ala 
65                  70                  75                  80  


Asn Thr Ser Gln Pro Asp Ile Val Glu Gly Gly Ala Val Tyr Tyr Cys 
                85                  90                  95      


Pro Trp Pro Ala Glu Gly Ser Ala Gln Cys Arg Gln Ile Pro Phe Asp 
            100                 105                 110         


Thr Thr Asn Asn Arg Lys Ile Arg Val Asn Gly Thr Lys Glu Pro Ile 
        115                 120                 125             


Glu Phe Lys Ser Asn Gln Trp Phe Gly Ala Thr Val Lys Ala His Lys 
    130                 135                 140                 


Gly Lys Val Val Ala Cys Ala Pro Leu Tyr His Trp Arg Thr Leu Lys 
145                 150                 155                 160 


Pro Thr Pro Glu Lys Asp Pro Val Gly Thr Cys Tyr Val Ala Ile Gln 
                165                 170                 175     


Asn Phe Ser Ala Tyr Ala Glu Phe Ser Pro Cys Arg Asn Ser Asn Ala 
            180                 185                 190         


Asp Pro Glu Gly Gln Gly Tyr Cys Gln Ala Gly Phe Ser Leu Asp Phe 
        195                 200                 205             


Tyr Lys Asn Gly Asp Leu Ile Val Gly Gly Pro Gly Ser Phe Tyr Trp 
    210                 215                 220                 


Gln Gly Gln Val Ile Thr Ala Ser Val Ala Asp Ile Ile Ala Asn Tyr 
225                 230                 235                 240 


Ser Phe Lys Asp Ile Leu Arg Lys Leu Ala Gly Glu Lys Gln Thr Glu 
                245                 250                 255     


Val Ala Pro Ala Ser Tyr Asp Asp Ser Tyr Leu Gly Tyr Ser Val Ala 
            260                 265                 270         


Ala Gly Glu Phe Thr Gly Asp Ser Gln Gln Glu Leu Val Ala Gly Ile 
        275                 280                 285             


Pro Arg Gly Ala Gln Asn Phe Gly Tyr Val Ser Ile Ile Asn Ser Thr 
    290                 295                 300                 


Asp Met Thr Phe Ile Gln Asn Phe Thr Gly Glu Gln Met Ala Ser Tyr 
305                 310                 315                 320 


Phe Gly Tyr Thr Val Val Val Ser Asp Val Asn Ser Asp Gly Leu Asp 
                325                 330                 335     


Asp Val Leu Val Gly Ala Pro Leu Phe Met Glu Arg Glu Phe Glu Ser 
            340                 345                 350         


Asn Pro Arg Glu Val Gly Gln Ile Tyr Leu Tyr Leu Gln Val Ser Ser 
        355                 360                 365             


Leu Leu Phe Arg Asp Pro Gln Ile Leu Thr Gly Thr Glu Thr Phe Gly 
    370                 375                 380                 


Arg Phe Gly Ser Ala Met Ala His Leu Gly Asp Leu Asn Gln Asp Gly 
385                 390                 395                 400 


Tyr Asn Asp Ile Ala Ile Gly Val Pro Phe Ala Gly Lys Asp Gln Arg 
                405                 410                 415     


Gly Lys Val Leu Ile Tyr Asn Gly Asn Lys Asp Gly Leu Asn Thr Lys 
            420                 425                 430         


Pro Ser Gln Val Leu Gln Gly Val Trp Ala Ser His Ala Val Pro Ser 
        435                 440                 445             


Gly Phe Gly Phe Thr Leu Arg Gly Asp Ser Asp Ile Asp Lys Asn Asp 
    450                 455                 460                 


Tyr Pro Asp Leu Ile Val Gly Ala Phe Gly Thr Gly Lys Val Ala Val 
465                 470                 475                 480 


Tyr Arg Ala Arg Pro Val Val Thr Val Asp Ala Gln Leu Leu Leu His 
                485                 490                 495     


Pro Met Ile Ile Asn Leu Glu Asn Lys Thr Cys Gln Val Pro Asp Ser 
            500                 505                 510         


Met Thr Ser Ala Ala Cys Phe Ser Leu Arg Val Cys Ala Ser Val Thr 
        515                 520                 525             


Gly Gln Ser Ile Ala Asn Thr Ile Val Leu Met Ala Glu Val Gln Leu 
    530                 535                 540                 


Asp Ser Leu Lys Gln Lys Gly Ala Ile Lys Arg Thr Leu Phe Leu Asp 
545                 550                 555                 560 


Asn His Gln Ala His Arg Val Phe Pro Leu Val Ile Lys Arg Gln Lys 
                565                 570                 575     


Ser His Gln Cys Gln Asp Phe Ile Val Tyr Leu Arg Asp Glu Thr Glu 
            580                 585                 590         


Phe Arg Asp Lys Leu Ser Pro Ile Asn Ile Ser Leu Asn Tyr Ser Leu 
        595                 600                 605             


Asp Glu Ser Thr Phe Lys Glu Gly Leu Glu Val Lys Pro Ile Leu Asn 
    610                 615                 620                 


Tyr Tyr Arg Glu Asn Ile Val Ser Glu Gln Ala His Ile Leu Val Asp 
625                 630                 635                 640 


Cys Gly Glu Asp Asn Leu Cys Val Pro Asp Leu Lys Leu Ser Ala Arg 
                645                 650                 655     


Pro Asp Lys His Gln Val Ile Ile Gly Asp Glu Asn His Leu Met Leu 
            660                 665                 670         


Ile Ile Asn Ala Arg Asn Glu Gly Glu Gly Ala Tyr Glu Ala Glu Leu 
        675                 680                 685             


Phe Val Met Ile Pro Glu Glu Ala Asp Tyr Val Gly Ile Glu Arg Asn 
    690                 695                 700                 


Asn Lys Gly Phe Arg Pro Leu Ser Cys Glu Tyr Lys Met Glu Asn Val 
705                 710                 715                 720 


Thr Arg Met Val Val Cys Asp Leu Gly Asn Pro Met Val Ser Gly Thr 
                725                 730                 735     


Asn Tyr Ser Leu Gly Leu Arg Phe Ala Val Pro Arg Leu Glu Lys Thr 
            740                 745                 750         


Asn Met Ser Ile Asn Phe Asp Leu Gln Ile Arg Ser Ser Asn Lys Asp 
        755                 760                 765             


Asn Pro Asp Ser Asn Phe Val Ser Leu Gln Ile Asn Ile Thr Ala Val 
    770                 775                 780                 


Ala Gln Val Glu Ile Arg Gly Val Ser His Pro Pro Gln Ile Val Leu 
785                 790                 795                 800 


Pro Ile His Asn Trp Glu Pro Glu Glu Glu Pro His Lys Glu Glu Glu 
                805                 810                 815     


Val Gly Pro Leu Val Glu His Ile Tyr Glu Leu His Asn Ile Gly Pro 
            820                 825                 830         


Ser Thr Ile Ser Asp Thr Ile Leu Glu Val Gly Trp Pro Phe Ser Ala 
        835                 840                 845             


Arg Asp Glu Phe Leu Leu Tyr Ile Phe His Ile Gln Thr Leu Gly Pro 
    850                 855                 860                 


Leu Gln Cys Gln Pro Asn Pro Asn Ile Asn Pro Gln Asp Ile Lys Pro 
865                 870                 875                 880 


Ala Ala Ser Pro Glu Asp Thr Pro Glu Leu Ser Ala Phe Leu Arg Asn 
                885                 890                 895     


Ser Thr Ile Pro His Leu Val Arg Lys Arg Asp Val His Val Val Glu 
            900                 905                 910         


Phe His Arg Gln Ser Pro Ala Lys Ile Leu Asn Cys Thr Asn Ile Glu 
        915                 920                 925             


Cys Leu Gln Ile Ser Cys Ala Val Gly Arg Leu Glu Gly Gly Glu Ser 
    930                 935                 940                 


Ala Val Leu Lys Val Arg Ser Arg Leu Trp Ala His Thr Phe Leu Gln 
945                 950                 955                 960 


Arg Lys Asn Asp Pro Tyr Ala Leu Ala Ser Leu Val Ser Phe Glu Val 
                965                 970                 975     


Lys Lys Met Pro Tyr Thr Asp Gln Pro Ala Lys Leu Pro Glu Gly Ser 
            980                 985                 990         


Ile Val Ile Lys Thr Ser Val Ile  Trp Ala Thr Pro Asn  Val Ser Phe 
        995                 1000                 1005             


Ser Ile  Pro Leu Trp Val Ile  Ile Leu Ala Ile Leu  Leu Gly Leu 
    1010                 1015                 1020             


Leu Val  Leu Ala Ile Leu Thr  Leu Ala Leu Trp Lys  Cys Gly Phe 
    1025                 1030                 1035             


Phe Asp  Arg Ala Arg Pro Pro  Gln Glu Asp Met Thr  Asp Arg Glu 
    1040                 1045                 1050             


Gln Leu  Thr Asn Asp Lys Thr  Pro Glu Ala 
    1055                 1060             


<210>  84
<211>  1180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  84

Met Ser Ala Asp Ser Ser Pro Leu Val Gly Ser Thr Pro Thr Gly Tyr 
1               5                   10                  15      


Gly Thr Leu Thr Ile Gly Thr Ser Ile Asp Pro Leu Ser Ser Ser Val 
            20                  25                  30          


Ser Ser Val Arg Leu Ser Gly Tyr Cys Gly Ser Pro Trp Arg Val Ile 
        35                  40                  45              


Gly Tyr His Val Val Val Trp Met Met Ala Gly Ile Pro Leu Leu Leu 
    50                  55                  60                  


Phe Arg Trp Lys Pro Leu Trp Gly Val Arg Leu Arg Leu Arg Pro Cys 
65                  70                  75                  80  


Asn Leu Ala His Ala Glu Thr Leu Val Ile Glu Ile Arg Asp Lys Glu 
                85                  90                  95      


Asp Ser Ser Trp Gln Leu Phe Thr Val Gln Val Gln Thr Glu Ala Ile 
            100                 105                 110         


Gly Glu Gly Ser Leu Glu Pro Ser Pro Gln Ser Gln Ala Glu Asp Gly 
        115                 120                 125             


Arg Ser Gln Ala Ala Val Gly Ala Val Pro Glu Gly Ala Trp Lys Asp 
    130                 135                 140                 


Thr Ala Gln Leu His Lys Ser Glu Glu Ala Val Ser Val Gly Gln Lys 
145                 150                 155                 160 


Arg Val Leu Arg Tyr Tyr Leu Phe Gln Gly Gln Arg Tyr Ile Trp Ile 
                165                 170                 175     


Glu Thr Gln Gln Ala Phe Tyr Gln Val Ser Leu Leu Asp His Gly Arg 
            180                 185                 190         


Ser Cys Asp Asp Val His Arg Ser Arg His Gly Leu Ser Leu Gln Asp 
        195                 200                 205             


Gln Met Val Arg Lys Ala Ile Tyr Gly Pro Asn Val Ile Ser Ile Pro 
    210                 215                 220                 


Val Lys Ser Tyr Pro Gln Leu Leu Val Asp Glu Ala Leu Asn Pro Tyr 
225                 230                 235                 240 


Tyr Gly Phe Gln Ala Phe Ser Ile Ala Leu Trp Leu Ala Asp His Tyr 
                245                 250                 255     


Tyr Trp Tyr Ala Leu Cys Ile Phe Leu Ile Ser Ser Ile Ser Ile Cys 
            260                 265                 270         


Leu Ser Leu Tyr Lys Thr Arg Lys Gln Ser Gln Thr Leu Arg Asp Met 
        275                 280                 285             


Val Lys Leu Ser Met Arg Val Cys Val Cys Arg Pro Gly Gly Glu Glu 
    290                 295                 300                 


Glu Trp Val Asp Ser Ser Glu Leu Val Pro Gly Asp Cys Leu Val Leu 
305                 310                 315                 320 


Pro Gln Glu Gly Gly Leu Met Pro Cys Asp Ala Ala Leu Val Ala Gly 
                325                 330                 335     


Glu Cys Met Val Asn Glu Ser Ser Leu Thr Gly Glu Ser Ile Pro Val 
            340                 345                 350         


Leu Lys Thr Ala Leu Pro Glu Gly Leu Gly Pro Tyr Cys Ala Glu Thr 
        355                 360                 365             


His Arg Arg His Thr Leu Phe Cys Gly Thr Leu Ile Leu Gln Ala Arg 
    370                 375                 380                 


Ala Tyr Val Gly Pro His Val Leu Ala Val Val Thr Arg Thr Gly Phe 
385                 390                 395                 400 


Cys Thr Ala Lys Gly Gly Leu Val Ser Ser Ile Leu His Pro Arg Pro 
                405                 410                 415     


Ile Asn Phe Lys Phe Tyr Lys His Ser Met Lys Phe Val Ala Ala Leu 
            420                 425                 430         


Ser Val Leu Ala Leu Leu Gly Thr Ile Tyr Ser Ile Phe Ile Leu Tyr 
        435                 440                 445             


Arg Asn Arg Val Pro Leu Asn Glu Ile Val Ile Arg Ala Leu Asp Leu 
    450                 455                 460                 


Val Thr Val Val Val Pro Pro Ala Leu Pro Ala Ala Met Thr Val Cys 
465                 470                 475                 480 


Thr Leu Tyr Ala Gln Ser Arg Leu Arg Arg Gln Gly Ile Phe Cys Ile 
                485                 490                 495     


His Pro Leu Arg Ile Asn Leu Gly Gly Lys Leu Gln Leu Val Cys Phe 
            500                 505                 510         


Asp Lys Thr Gly Thr Leu Thr Glu Asp Gly Leu Asp Val Met Gly Val 
        515                 520                 525             


Val Pro Leu Lys Gly Gln Ala Phe Leu Pro Leu Val Pro Glu Pro Arg 
    530                 535                 540                 


Arg Leu Pro Val Gly Pro Leu Leu Arg Ala Leu Ala Thr Cys His Ala 
545                 550                 555                 560 


Leu Ser Arg Leu Gln Asp Thr Pro Val Gly Asp Pro Met Asp Leu Lys 
                565                 570                 575     


Met Val Glu Ser Thr Gly Trp Val Leu Glu Glu Glu Pro Ala Ala Asp 
            580                 585                 590         


Ser Ala Phe Gly Thr Gln Val Leu Ala Val Met Arg Pro Pro Leu Trp 
        595                 600                 605             


Glu Pro Gln Leu Gln Ala Met Glu Glu Pro Pro Val Pro Val Ser Val 
    610                 615                 620                 


Leu His Arg Phe Pro Phe Ser Ser Ala Leu Gln Arg Met Ser Val Val 
625                 630                 635                 640 


Val Ala Trp Pro Gly Ala Thr Gln Pro Glu Ala Tyr Val Lys Gly Ser 
                645                 650                 655     


Pro Glu Leu Val Ala Gly Leu Cys Asn Pro Glu Thr Val Pro Thr Asp 
            660                 665                 670         


Phe Ala Gln Met Leu Gln Ser Tyr Thr Ala Ala Gly Tyr Arg Val Val 
        675                 680                 685             


Ala Leu Ala Ser Lys Pro Leu Pro Thr Val Pro Ser Leu Glu Ala Ala 
    690                 695                 700                 


Gln Gln Leu Thr Arg Asp Thr Val Glu Gly Asp Leu Ser Leu Leu Gly 
705                 710                 715                 720 


Leu Leu Val Met Arg Asn Leu Leu Lys Pro Gln Thr Thr Pro Val Ile 
                725                 730                 735     


Gln Ala Leu Arg Arg Thr Arg Ile Arg Ala Val Met Val Thr Gly Asp 
            740                 745                 750         


Asn Leu Gln Thr Ala Val Thr Val Ala Arg Gly Cys Gly Met Val Ala 
        755                 760                 765             


Pro Gln Glu His Leu Ile Ile Val His Ala Thr His Pro Glu Arg Gly 
    770                 775                 780                 


Gln Pro Ala Ser Leu Glu Phe Leu Pro Met Glu Ser Pro Thr Ala Val 
785                 790                 795                 800 


Asn Gly Val Lys Asp Pro Asp Gln Ala Ala Ser Tyr Thr Val Glu Pro 
                805                 810                 815     


Asp Pro Arg Ser Arg His Leu Ala Leu Ser Gly Pro Thr Phe Gly Ile 
            820                 825                 830         


Ile Val Lys His Phe Pro Lys Leu Leu Pro Lys Val Leu Val Gln Gly 
        835                 840                 845             


Thr Val Phe Ala Arg Met Ala Pro Glu Gln Lys Thr Glu Leu Val Cys 
    850                 855                 860                 


Glu Leu Gln Lys Leu Gln Tyr Cys Val Gly Met Cys Gly Asp Gly Ala 
865                 870                 875                 880 


Asn Asp Cys Gly Ala Leu Lys Ala Ala Asp Val Gly Ile Ser Leu Ser 
                885                 890                 895     


Gln Ala Glu Ala Ser Val Val Ser Pro Phe Thr Ser Ser Met Ala Ser 
            900                 905                 910         


Ile Glu Cys Val Pro Met Val Ile Arg Glu Gly Arg Cys Ser Leu Asp 
        915                 920                 925             


Thr Ser Phe Ser Val Phe Lys Tyr Met Ala Leu Tyr Ser Leu Thr Gln 
    930                 935                 940                 


Phe Ile Ser Val Leu Ile Leu Tyr Thr Ile Asn Thr Asn Leu Gly Asp 
945                 950                 955                 960 


Leu Gln Phe Leu Ala Ile Asp Leu Val Ile Thr Thr Thr Val Ala Val 
                965                 970                 975     


Leu Met Ser Arg Thr Gly Pro Ala Leu Val Leu Gly Arg Val Arg Pro 
            980                 985                 990         


Pro Gly Ala Leu Leu Ser Val Pro  Val Leu Ser Ser Leu  Leu Leu Gln 
        995                 1000                 1005             


Met Val  Leu Val Thr Gly Val  Gln Leu Gly Gly Tyr  Phe Leu Thr 
    1010                 1015                 1020             


Leu Ala  Gln Pro Trp Phe Val  Pro Leu Asn Arg Thr  Val Ala Ala 
    1025                 1030                 1035             


Pro Asp  Asn Leu Pro Asn Tyr  Glu Asn Thr Val Val  Phe Ser Leu 
    1040                 1045                 1050             


Ser Ser  Phe Gln Tyr Leu Ile  Leu Ala Ala Ala Val  Ser Lys Gly 
    1055                 1060                 1065             


Ala Pro  Phe Arg Arg Pro Leu  Tyr Thr Asn Val Pro  Phe Leu Val 
    1070                 1075                 1080             


Ala Leu  Ala Leu Leu Ser Ser  Val Leu Val Gly Leu  Val Leu Val 
    1085                 1090                 1095             


Pro Gly  Leu Leu Gln Gly Pro  Leu Ala Leu Arg Asn  Ile Thr Asp 
    1100                 1105                 1110             


Thr Gly  Phe Lys Leu Leu Leu  Leu Gly Leu Val Thr  Leu Asn Phe 
    1115                 1120                 1125             


Val Gly  Ala Phe Met Leu Glu  Ser Val Leu Asp Gln  Cys Leu Pro 
    1130                 1135                 1140             


Ala Cys  Leu Arg Arg Leu Arg  Pro Lys Arg Ala Ser  Lys Lys Arg 
    1145                 1150                 1155             


Phe Lys  Gln Leu Glu Arg Glu  Leu Ala Glu Gln Pro  Trp Pro Pro 
    1160                 1165                 1170             


Leu Pro  Ala Gly Pro Leu Arg  
    1175                 1180 


<210>  85
<211>  942
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  85

Met Ala Ala Ala Ala Glu Pro Gly Ala Arg Ala Trp Leu Gly Gly Gly 
1               5                   10                  15      


Ser Pro Arg Pro Gly Ser Pro Ala Cys Ser Pro Val Leu Gly Ser Gly 
            20                  25                  30          


Gly Arg Ala Arg Pro Gly Pro Gly Pro Gly Pro Gly Pro Glu Arg Ala 
        35                  40                  45              


Gly Val Arg Ala Pro Gly Pro Ala Ala Ala Pro Gly His Ser Phe Arg 
    50                  55                  60                  


Lys Val Thr Leu Thr Lys Pro Thr Phe Cys His Leu Cys Ser Asp Phe 
65                  70                  75                  80  


Ile Trp Gly Leu Ala Gly Phe Leu Cys Asp Val Cys Asn Phe Met Ser 
                85                  90                  95      


His Glu Lys Cys Leu Lys His Val Arg Ile Pro Cys Thr Ser Val Ala 
            100                 105                 110         


Pro Ser Leu Val Arg Val Pro Val Ala His Cys Phe Gly Pro Arg Gly 
        115                 120                 125             


Leu His Lys Arg Lys Phe Cys Ala Val Cys Arg Lys Val Leu Glu Ala 
    130                 135                 140                 


Pro Ala Leu His Cys Glu Val Cys Glu Leu His Leu His Pro Asp Cys 
145                 150                 155                 160 


Val Pro Phe Ala Cys Ser Asp Cys Arg Gln Cys His Gln Asp Gly His 
                165                 170                 175     


Gln Asp His Asp Thr His His His His Trp Arg Glu Gly Asn Leu Pro 
            180                 185                 190         


Ser Gly Ala Arg Cys Glu Val Cys Arg Lys Thr Cys Gly Ser Ser Asp 
        195                 200                 205             


Val Leu Ala Gly Val Arg Cys Glu Trp Cys Gly Val Gln Ala His Ser 
    210                 215                 220                 


Leu Cys Ser Ala Ala Leu Ala Pro Glu Cys Gly Phe Gly Arg Leu Arg 
225                 230                 235                 240 


Ser Leu Val Leu Pro Pro Ala Cys Val Arg Leu Leu Pro Gly Gly Phe 
                245                 250                 255     


Ser Lys Thr Gln Ser Phe Arg Ile Val Glu Ala Ala Glu Pro Gly Glu 
            260                 265                 270         


Gly Gly Asp Gly Ala Asp Gly Ser Ala Ala Val Gly Pro Gly Arg Glu 
        275                 280                 285             


Thr Gln Ala Thr Pro Glu Ser Gly Lys Gln Thr Leu Lys Ile Phe Asp 
    290                 295                 300                 


Gly Asp Asp Ala Val Arg Arg Ser Gln Phe Arg Leu Val Thr Val Ser 
305                 310                 315                 320 


Arg Leu Ala Gly Ala Glu Glu Val Leu Glu Ala Ala Leu Arg Ala His 
                325                 330                 335     


His Ile Pro Glu Asp Pro Gly His Leu Glu Leu Cys Arg Leu Pro Pro 
            340                 345                 350         


Ser Ser Gln Ala Cys Asp Ala Trp Ala Gly Gly Lys Ala Gly Ser Ala 
        355                 360                 365             


Val Ile Ser Glu Glu Gly Arg Ser Pro Gly Ser Gly Glu Ala Thr Pro 
    370                 375                 380                 


Glu Ala Trp Val Ile Arg Ala Leu Pro Arg Ala Gln Glu Val Leu Lys 
385                 390                 395                 400 


Ile Tyr Pro Gly Trp Leu Lys Val Gly Val Ala Tyr Val Ser Val Arg 
                405                 410                 415     


Val Thr Pro Lys Ser Thr Ala Arg Ser Val Val Leu Glu Val Leu Pro 
            420                 425                 430         


Leu Leu Gly Arg Gln Ala Glu Ser Pro Glu Ser Phe Gln Leu Val Glu 
        435                 440                 445             


Val Ala Met Gly Cys Arg His Val Gln Arg Thr Met Leu Met Asp Glu 
    450                 455                 460                 


Gln Pro Leu Leu Asp Arg Leu Gln Asp Ile Arg Gln Met Ser Val Arg 
465                 470                 475                 480 


Gln Val Ser Gln Thr Arg Phe Tyr Val Ala Glu Ser Arg Asp Val Ala 
                485                 490                 495     


Pro His Val Ser Leu Phe Val Gly Gly Leu Pro Pro Gly Leu Ser Pro 
            500                 505                 510         


Glu Glu Tyr Ser Ser Leu Leu His Glu Ala Gly Ala Thr Lys Ala Thr 
        515                 520                 525             


Val Val Ser Val Ser His Ile Tyr Ser Ser Gln Gly Ala Val Val Leu 
    530                 535                 540                 


Asp Val Ala Cys Phe Ala Glu Ala Glu Arg Leu Tyr Met Leu Leu Lys 
545                 550                 555                 560 


Asp Met Ala Val Arg Gly Arg Leu Leu Thr Ala Leu Val Leu Pro Asp 
                565                 570                 575     


Leu Leu His Ala Lys Leu Pro Pro Asp Ser Cys Pro Leu Leu Val Phe 
            580                 585                 590         


Val Asn Pro Lys Ser Gly Gly Leu Lys Gly Arg Asp Leu Leu Cys Ser 
        595                 600                 605             


Phe Arg Lys Leu Leu Asn Pro His Gln Val Phe Asp Leu Thr Asn Gly 
    610                 615                 620                 


Gly Pro Leu Pro Gly Leu His Leu Phe Ser Gln Val Pro Cys Phe Arg 
625                 630                 635                 640 


Val Leu Val Cys Gly Gly Asp Gly Thr Val Gly Trp Val Leu Gly Ala 
                645                 650                 655     


Leu Glu Glu Thr Arg Tyr Arg Leu Ala Cys Pro Glu Pro Ser Val Ala 
            660                 665                 670         


Ile Leu Pro Leu Gly Thr Gly Asn Asp Leu Gly Arg Val Leu Arg Trp 
        675                 680                 685             


Gly Ala Gly Tyr Ser Gly Glu Asp Pro Phe Ser Val Leu Leu Ser Val 
    690                 695                 700                 


Asp Glu Ala Asp Ala Val Leu Met Asp Arg Trp Thr Ile Leu Leu Asp 
705                 710                 715                 720 


Ala His Glu Ala Gly Ser Ala Glu Asn Asp Thr Ala Asp Ala Glu Pro 
                725                 730                 735     


Pro Lys Ile Val Gln Met Ser Asn Tyr Cys Gly Ile Gly Ile Asp Ala 
            740                 745                 750         


Glu Leu Ser Leu Asp Phe His Gln Ala Arg Glu Glu Glu Pro Gly Lys 
        755                 760                 765             


Phe Thr Ser Arg Leu His Asn Lys Gly Val Tyr Val Arg Val Gly Leu 
    770                 775                 780                 


Gln Lys Ile Ser His Ser Arg Ser Leu His Lys Gln Ile Arg Leu Gln 
785                 790                 795                 800 


Val Glu Arg Gln Glu Val Glu Leu Pro Ser Ile Glu Gly Leu Ile Phe 
                805                 810                 815     


Ile Asn Ile Pro Ser Trp Gly Ser Gly Ala Asp Leu Trp Gly Ser Asp 
            820                 825                 830         


Ser Asp Thr Arg Phe Glu Lys Pro Arg Met Asp Asp Gly Leu Leu Glu 
        835                 840                 845             


Val Val Gly Val Thr Gly Val Val His Met Gly Gln Val Gln Gly Gly 
    850                 855                 860                 


Leu Arg Ser Gly Ile Arg Ile Ala Gln Gly Ser Tyr Phe Arg Val Thr 
865                 870                 875                 880 


Leu Leu Lys Ala Thr Pro Val Gln Val Asp Gly Glu Pro Trp Val Gln 
                885                 890                 895     


Ala Pro Gly His Met Ile Ile Ser Ala Ala Gly Pro Lys Val His Met 
            900                 905                 910         


Leu Arg Lys Ala Lys Gln Lys Pro Arg Arg Ala Gly Thr Thr Arg Asp 
        915                 920                 925             


Ala Arg Ala Asp Ala Ala Pro Ala Pro Glu Ser Asp Pro Arg 
    930                 935                 940         


<210>  86
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  86

Met Lys Asp Arg Thr Gln Glu Leu Arg Ser Ala Lys Asp Ser Asp Asp 
1               5                   10                  15      


Glu Glu Glu Val Val His Val Asp Arg Asp His Phe Met Asp Glu Phe 
            20                  25                  30          


Phe Glu Gln Val Glu Glu Ile Arg Gly Cys Ile Glu Lys Leu Ser Glu 
        35                  40                  45              


Asp Val Glu Gln Val Lys Lys Gln His Ser Ala Ile Leu Ala Ala Pro 
    50                  55                  60                  


Asn Pro Asp Glu Lys Thr Lys Gln Glu Leu Glu Asp Leu Thr Ala Asp 
65                  70                  75                  80  


Ile Lys Lys Thr Ala Asn Lys Val Arg Ser Lys Leu Lys Ala Ile Glu 
                85                  90                  95      


Gln Ser Ile Glu Gln Glu Glu Gly Leu Asn Arg Ser Ser Ala Asp Leu 
            100                 105                 110         


Arg Ile Arg Lys Thr Gln His Ser Thr Leu Ser Arg Lys Phe Val Glu 
        115                 120                 125             


Val Met Thr Glu Tyr Asn Ala Thr Gln Ser Lys Tyr Arg Asp Arg Cys 
    130                 135                 140                 


Lys Asp Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Arg Thr Thr Thr 
145                 150                 155                 160 


Asn Glu Glu Leu Glu Asp Met Leu Glu Ser Gly Lys Leu Ala Ile Phe 
                165                 170                 175     


Thr Asp Asp Ile Lys Met Asp Ser Gln Met Thr Lys Gln Ala Leu Asn 
            180                 185                 190         


Glu Ile Glu Thr Arg His Asn Glu Ile Ile Lys Leu Glu Thr Ser Ile 
        195                 200                 205             


Arg Glu Leu His Asp Met Phe Val Asp Met Ala Met Leu Val Glu Ser 
    210                 215                 220                 


Gln Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val Glu His Ser Val 
225                 230                 235                 240 


Asp Tyr Val Glu Arg Ala Val Ser Asp Thr Lys Lys Ala Val Lys Tyr 
                245                 250                 255     


Gln Ser Lys Ala Arg Arg Lys Lys Ile Met Ile Ile Ile Cys Cys Val 
            260                 265                 270         


Val Leu Gly Val Val Leu Ala Ser Ser Ile Gly Gly Thr Leu Gly Leu 
        275                 280                 285             


<210>  87
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  87

Met Ser Arg Pro Val Arg Asn Arg Lys Val Val Asp Tyr Ser Gln Phe 
1               5                   10                  15      


Gln Glu Ser Asp Asp Ala Asp Glu Asp Tyr Gly Arg Asp Ser Gly Pro 
            20                  25                  30          


Pro Thr Lys Lys Ile Arg Ser Ser Pro Arg Glu Ala Lys Asn Lys Arg 
        35                  40                  45              


Arg Ser Gly Lys Asn Ser Gln Glu Asp Ser Glu Asp Ser Glu Asp Lys 
    50                  55                  60                  


Asp Val Lys Thr Lys Lys Asp Asp Ser His Ser Ala Glu Asp Ser Glu 
65                  70                  75                  80  


Asp Glu Lys Glu Asp His Lys Asn Val Arg Gln Gln Arg Gln Ala Ala 
                85                  90                  95      


Ser Lys Ala Ala Ser Lys Gln Arg Glu Met Leu Met Glu Asp Val Gly 
            100                 105                 110         


Ser Glu Glu Glu Gln Glu Glu Glu Asp Glu Ala Pro Phe Gln Glu Lys 
        115                 120                 125             


Asp Ser Gly Ser Asp Glu Asp Phe Leu Met Glu Asp Asp Asp Asp Ser 
    130                 135                 140                 


Asp Tyr Gly Ser Ser Lys Lys Lys Asn Lys Lys Met Val Lys Lys Ser 
145                 150                 155                 160 


Lys Pro Glu Arg Lys Glu Lys Lys Met Pro Lys Pro Arg Leu Lys Ala 
                165                 170                 175     


Thr Val Thr Pro Ser Pro Val Lys Gly Lys Gly Lys Val Gly Arg Pro 
            180                 185                 190         


Thr Ala Ser Lys Ala Ser Lys Glu Lys Thr Pro Ser Pro Lys Glu Glu 
        195                 200                 205             


Asp Glu Glu Pro Glu Ser Pro Pro Glu Lys Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Pro Pro Glu Lys Ser Gly Asp Glu Gly Ser Glu Asp Glu Ala Pro Ser 
225                 230                 235                 240 


Gly Glu Asp 
            


<210>  88
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  88

Met Lys Ile Asp Ile His Ser His Ile Leu Pro Lys Glu Trp Pro Asp 
1               5                   10                  15      


Leu Lys Lys Arg Phe Gly Tyr Gly Gly Trp Val Gln Leu Gln His His 
            20                  25                  30          


Ser Lys Gly Glu Ala Lys Leu Leu Lys Asp Gly Lys Val Phe Arg Val 
        35                  40                  45              


Val Arg Glu Asn Cys Trp Asp Pro Glu Val Arg Ile Arg Glu Met Asp 
    50                  55                  60                  


Gln Lys Gly Val Thr Val Gln Ala Leu Ser Thr Val Pro Val Met Phe 
65                  70                  75                  80  


Ser Tyr Trp Ala Lys Pro Glu Asp Thr Leu Asn Leu Cys Gln Leu Leu 
                85                  90                  95      


Asn Asn Asp Leu Ala Ser Thr Val Val Ser Tyr Pro Arg Arg Phe Val 
            100                 105                 110         


Gly Leu Gly Thr Leu Pro Met Gln Ala Pro Glu Leu Ala Val Lys Glu 
        115                 120                 125             


Met Glu Arg Cys Val Lys Glu Leu Gly Phe Pro Gly Val Gln Ile Gly 
    130                 135                 140                 


Thr His Val Asn Glu Trp Asp Leu Asn Ala Gln Glu Leu Phe Pro Val 
145                 150                 155                 160 


Tyr Ala Ala Ala Glu Arg Leu Lys Cys Ser Leu Phe Val His Pro Trp 
                165                 170                 175     


Asp Met Gln Met Asp Gly Arg Met Ala Lys Tyr Trp Leu Pro Trp Leu 
            180                 185                 190         


Val Gly Met Pro Ala Glu Thr Thr Ile Ala Ile Cys Ser Met Ile Met 
        195                 200                 205             


Gly Gly Val Phe Glu Lys Phe Pro Lys Leu Lys Val Cys Phe Ala His 
    210                 215                 220                 


Gly Gly Gly Ala Phe Pro Phe Thr Val Gly Arg Ile Ser His Gly Phe 
225                 230                 235                 240 


Ser Met Arg Pro Asp Leu Cys Ala Gln Asp Asn Pro Met Asn Pro Lys 
                245                 250                 255     


Lys Tyr Leu Gly Ser Phe Tyr Thr Asp Ala Leu Val His Asp Pro Leu 
            260                 265                 270         


Ser Leu Lys Leu Leu Thr Asp Val Ile Gly Lys Asp Lys Val Ile Leu 
        275                 280                 285             


Gly Thr Asp Tyr Pro Phe Pro Leu Gly Glu Leu Glu Pro Gly Lys Leu 
    290                 295                 300                 


Ile Glu Ser Met Glu Glu Phe Asp Glu Glu Thr Lys Asn Lys Leu Lys 
305                 310                 315                 320 


Ala Gly Asn Ala Leu Ala Phe Leu Gly Leu Glu Arg Lys Gln Phe Glu 
                325                 330                 335     


<210>  89
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  89

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
            20                  25                  30          


Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
        35                  40                  45              


Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
    50                  55                  60                  


Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
65                  70                  75                  80  


Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                85                  90                  95      


Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
            100                 105                 110         


Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
        115                 120                 125             


Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
    130                 135                 140                 


Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
145                 150                 155                 160 


Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                165                 170                 175     


Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
        195                 200                 205             


Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
225                 230                 235                 240 


Gly Val Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                245                 250                 


<210>  90
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  90

Met Ser Thr Leu Cys Pro Pro Pro Ser Pro Ala Val Ala Lys Thr Glu 
1               5                   10                  15      


Ile Ala Leu Ser Gly Lys Ser Pro Leu Leu Ala Ala Thr Phe Ala Tyr 
            20                  25                  30          


Trp Asp Asn Ile Leu Gly Pro Arg Val Arg His Ile Trp Ala Pro Lys 
        35                  40                  45              


Thr Glu Gln Val Leu Leu Ser Asp Gly Glu Ile Thr Phe Leu Ala Asn 
    50                  55                  60                  


His Thr Leu Asn Gly Glu Ile Leu Arg Asn Ala Glu Ser Gly Ala Ile 
65                  70                  75                  80  


Asp Val Lys Phe Phe Val Leu Ser Glu Lys Gly Val Ile Ile Val Ser 
                85                  90                  95      


Leu Ile Phe Asp Gly Asn Trp Asn Gly Asp Arg Ser Thr Tyr Gly Leu 
            100                 105                 110         


Ser Ile Ile Leu Pro Gln Thr Glu Leu Ser Phe Tyr Leu Pro Leu His 
        115                 120                 125             


Arg Val Cys Val Asp Arg Leu Thr His Ile Ile Arg Lys Gly Arg Ile 
    130                 135                 140                 


Trp Met His Lys Glu Arg Gln Glu Asn Val Gln Lys Ile Ile Leu Glu 
145                 150                 155                 160 


Gly Thr Glu Arg Met Glu Asp Gln Gly Gln Ser Ile Ile Pro Met Leu 
                165                 170                 175     


Thr Gly Glu Val Ile Pro Val Met Glu Leu Leu Ser Ser Met Lys Ser 
            180                 185                 190         


His Ser Val Pro Glu Glu Ile Asp Ile Ala Asp Thr Val Leu Asn Asp 
        195                 200                 205             


Asp Asp Ile Gly Asp Ser Cys His Glu Gly Phe Leu Leu Asn Ala Ile 
    210                 215                 220                 


Ser Ser His Leu Gln Thr Cys Gly Cys Ser Val Val Val Gly Ser Ser 
225                 230                 235                 240 


Ala Glu Lys Val Asn Lys Ile Val Arg Thr Leu Cys Leu Phe Leu Thr 
                245                 250                 255     


Pro Ala Glu Arg Lys Cys Ser Arg Leu Cys Glu Ala Glu Ser Ser Phe 
            260                 265                 270         


Lys Tyr Glu Ser Gly Leu Phe Val Gln Gly Leu Leu Lys Asp Ser Thr 
        275                 280                 285             


Gly Ser Phe Val Leu Pro Phe Arg Gln Val Met Tyr Ala Pro Tyr Pro 
    290                 295                 300                 


Thr Thr His Ile Asp Val Asp Val Asn Thr Val Lys Gln Met Pro Pro 
305                 310                 315                 320 


Cys His Glu His Ile Tyr Asn Gln Arg Arg Tyr Met Arg Ser Glu Leu 
                325                 330                 335     


Thr Ala Phe Trp Arg Ala Thr Ser Glu Glu Asp Met Ala Gln Asp Thr 
            340                 345                 350         


Ile Ile Tyr Thr Asp Glu Ser Phe Thr Pro Asp Leu Asn Ile Phe Gln 
        355                 360                 365             


Asp Val Leu His Arg Asp Thr Leu Val Lys Ala Phe Leu Asp Gln Val 
    370                 375                 380                 


Phe Gln Leu Lys Pro Gly Leu Ser Leu Arg Ser Thr Phe Leu Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Val Leu His Arg Lys Ala Leu Thr Leu Ile Lys Tyr Ile 
                405                 410                 415     


Glu Asp Asp Thr Gln Lys Gly Lys Lys Pro Phe Lys Ser Leu Arg Asn 
            420                 425                 430         


Leu Lys Ile Asp Leu Asp Leu Thr Ala Glu Gly Asp Leu Asn Ile Ile 
        435                 440                 445             


Met Ala Leu Ala Glu Lys Ile Lys Pro Gly Leu His Ser Phe Ile Phe 
    450                 455                 460                 


Gly Arg Pro Phe Tyr Thr Ser Val Gln Glu Arg Asp Val Leu Met Thr 
465                 470                 475                 480 


Phe 
    


<210>  91
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  91

Met Ala Ser Leu Thr Val Lys Ala Tyr Leu Leu Gly Lys Glu Asp Ala 
1               5                   10                  15      


Ala Arg Glu Ile Arg Arg Phe Ser Phe Cys Cys Ser Pro Glu Pro Glu 
            20                  25                  30          


Ala Glu Ala Glu Ala Ala Ala Gly Pro Gly Pro Cys Glu Arg Leu Leu 
        35                  40                  45              


Ser Arg Val Ala Ala Leu Phe Pro Ala Leu Arg Pro Gly Gly Phe Gln 
    50                  55                  60                  


Ala His Tyr Arg Asp Glu Asp Gly Asp Leu Val Ala Phe Ser Ser Asp 
65                  70                  75                  80  


Glu Glu Leu Thr Met Ala Met Ser Tyr Val Lys Asp Asp Ile Phe Arg 
                85                  90                  95      


Ile Tyr Ile Lys Glu Lys Lys Glu Cys Arg Arg Asp His Arg Pro Pro 
            100                 105                 110         


Cys Ala Gln Glu Ala Pro Arg Asn Met Val His Pro Asn Val Ile Cys 
        115                 120                 125             


Asp Gly Cys Asn Gly Pro Val Val Gly Thr Arg Tyr Lys Cys Ser Val 
    130                 135                 140                 


Cys Pro Asp Tyr Asp Leu Cys Ser Val Cys Glu Gly Lys Gly Leu His 
145                 150                 155                 160 


Arg Gly His Thr Lys Leu Ala Phe Pro Ser Pro Phe Gly His Leu Ser 
                165                 170                 175     


Glu Gly Phe Ser His Ser Arg Trp Leu Arg Lys Val Lys His Gly His 
            180                 185                 190         


Phe Gly Trp Pro Gly Trp Glu Met Gly Pro Pro Gly Asn Trp Ser Pro 
        195                 200                 205             


Arg Pro Pro Arg Ala Gly Glu Ala Arg Pro Gly Pro Thr Ala Glu Ser 
    210                 215                 220                 


Ala Ser Gly Pro Ser Glu Asp Pro Ser Val Asn Phe Leu Lys Asn Val 
225                 230                 235                 240 


Gly Glu Ser Val Ala Ala Ala Leu Ser Pro Leu Gly Ile Glu Val Asp 
                245                 250                 255     


Ile Asp Val Glu His Gly Gly Lys Arg Ser Arg Leu Thr Pro Val Ser 
            260                 265                 270         


Pro Glu Ser Ser Ser Thr Glu Glu Lys Ser Ser Ser Gln Pro Ser Ser 
        275                 280                 285             


Cys Cys Ser Asp Pro Ser Lys Pro Gly Gly Asn Val Glu Gly Ala Thr 
    290                 295                 300                 


Gln Ser Leu Ala Glu Gln Met Arg Lys Ile Ala Leu Glu Ser Glu Gly 
305                 310                 315                 320 


Arg Pro Glu Glu Gln Met Glu Ser Asp Asn Cys Ser Gly Gly Asp Asp 
                325                 330                 335     


Asp Trp Thr His Leu Ser Ser Lys Glu Val Asp Pro Ser Thr Gly Glu 
            340                 345                 350         


Leu Gln Ser Leu Gln Met Pro Glu Ser Glu Gly Pro Ser Ser Leu Asp 
        355                 360                 365             


Pro Ser Gln Glu Gly Pro Thr Gly Leu Lys Glu Ala Ala Leu Tyr Pro 
    370                 375                 380                 


His Leu Pro Pro Glu Ala Asp Pro Arg Leu Ile Glu Ser Leu Ser Gln 
385                 390                 395                 400 


Met Leu Ser Met Gly Phe Ser Asp Glu Gly Gly Trp Leu Thr Arg Leu 
                405                 410                 415     


Leu Gln Thr Lys Asn Tyr Asp Ile Gly Ala Ala Leu Asp Thr Ile Gln 
            420                 425                 430         


Tyr Ser Lys His Pro Pro Pro Leu 
        435                 440 


<210>  92
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  92

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15      


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30          


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45              


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60                  


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80  


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95      


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110         


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125             


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140                 


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160 


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175     


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190         


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205             


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220                 


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240 


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255     


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270         


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285             


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300                 


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320 


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335     


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350         


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365             


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380                 


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400 


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410                 


<210>  93
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  93

Met Gln Ser Thr Ser Asn His Leu Trp Leu Leu Ser Asp Ile Leu Gly 
1               5                   10                  15      


Gln Gly Ala Thr Ala Asn Val Phe Arg Gly Arg His Lys Lys Thr Gly 
            20                  25                  30          


Asp Leu Phe Ala Ile Lys Val Phe Asn Asn Ile Ser Phe Leu Arg Pro 
        35                  40                  45              


Val Asp Val Gln Met Arg Glu Phe Glu Val Leu Lys Lys Leu Asn His 
    50                  55                  60                  


Lys Asn Ile Val Lys Leu Phe Ala Ile Glu Glu Glu Thr Thr Thr Arg 
65                  70                  75                  80  


His Lys Val Leu Ile Met Glu Phe Cys Pro Cys Gly Ser Leu Tyr Thr 
                85                  90                  95      


Val Leu Glu Glu Pro Ser Asn Ala Tyr Gly Leu Pro Glu Ser Glu Phe 
            100                 105                 110         


Leu Ile Val Leu Arg Asp Val Val Gly Gly Met Asn His Leu Arg Glu 
        115                 120                 125             


Asn Gly Ile Val His Arg Asp Ile Lys Pro Gly Asn Ile Met Arg Val 
    130                 135                 140                 


Ile Gly Glu Asp Gly Gln Ser Val Tyr Lys Leu Thr Asp Phe Gly Ala 
145                 150                 155                 160 


Ala Arg Glu Leu Glu Asp Asp Glu Gln Phe Val Ser Leu Tyr Gly Thr 
                165                 170                 175     


Glu Glu Tyr Leu His Pro Asp Met Tyr Glu Arg Ala Val Leu Arg Lys 
            180                 185                 190         


Asp His Gln Lys Lys Tyr Gly Ala Thr Val Asp Leu Trp Ser Ile Gly 
        195                 200                 205             


Val Thr Phe Tyr His Ala Ala Thr Gly Ser Leu Pro Phe Arg Pro Phe 
    210                 215                 220                 


Glu Gly Pro Arg Arg Asn Lys Glu Val Met Tyr Lys Ile Ile Thr Gly 
225                 230                 235                 240 


Lys Pro Ser Gly Ala Ile Ser Gly Val Gln Lys Ala Glu Asn Gly Pro 
                245                 250                 255     


Ile Asp Trp Ser Gly Asp Met Pro Val Ser Cys Ser Leu Ser Arg Gly 
            260                 265                 270         


Leu Gln Val Leu Leu Thr Pro Val Leu Ala Asn Ile Leu Glu Ala Asp 
        275                 280                 285             


Gln Glu Lys Cys Trp Gly Phe Asp Gln Phe Phe Ala Glu Thr Ser Asp 
    290                 295                 300                 


Ile Leu His Arg Met Val Ile His Val Phe Ser Leu Gln Gln Met Thr 
305                 310                 315                 320 


Ala His Lys Ile Tyr Ile His Ser Tyr Asn Thr Ala Thr Ile Phe His 
                325                 330                 335     


Glu Leu Val Tyr Lys Gln Thr Lys Ile Ile Ser Ser Asn Gln Glu Leu 
            340                 345                 350         


Ile Tyr Glu Gly Arg Arg Leu Val Leu Glu Pro Gly Arg Leu Ala Gln 
        355                 360                 365             


His Phe Pro Lys Thr Thr Glu Glu Asn Pro Ile Phe Val Val Ser Arg 
    370                 375                 380                 


Glu Pro Leu Asn Thr Ile Gly Leu Ile Tyr Glu Lys Ile Ser Leu Pro 
385                 390                 395                 400 


Lys Val His Pro Arg Tyr Asp Leu Asp Gly Asp Ala Ser Met Ala Lys 
                405                 410                 415     


Ala Ile Thr Gly Val Val Cys Tyr Ala Cys Arg Ile Ala Ser Thr Leu 
            420                 425                 430         


Leu Leu Tyr Gln Glu Leu Met Arg Lys Gly Ile Arg Trp Leu Ile Glu 
        435                 440                 445             


Leu Ile Lys Asp Asp Tyr Asn Glu Thr Val His Lys Lys Thr Glu Val 
    450                 455                 460                 


Val Ile Thr Leu Asp Phe Cys Ile Arg Asn Ile Glu Lys Thr Val Lys 
465                 470                 475                 480 


Val Tyr Glu Lys Leu Met Lys Ile Asn Leu Glu Ala Ala Glu Leu Gly 
                485                 490                 495     


Glu Ile Ser Asp Ile His Thr Lys Leu Leu Arg Leu Ser Ser Ser Gln 
            500                 505                 510         


Gly Thr Ile Glu Thr Ser Leu Gln Asp Ile Asp Ser Arg Leu Ser Pro 
        515                 520                 525             


Gly Gly Ser Leu Ala Asp Ala Trp Ala His Gln Glu Gly Thr His Pro 
    530                 535                 540                 


Lys Asp Arg Asn Val Glu Lys Leu Gln Val Leu Leu Asn Cys Met Thr 
545                 550                 555                 560 


Glu Ile Tyr Tyr Gln Phe Lys Lys Asp Lys Ala Glu Arg Arg Leu Ala 
                565                 570                 575     


Tyr Asn Glu Glu Gln Ile His Lys Phe Asp Lys Gln Lys Leu Tyr Tyr 
            580                 585                 590         


His Ala Thr Lys Ala Met Thr His Phe Thr Asp Glu Cys Val Lys Lys 
        595                 600                 605             


Tyr Glu Ala Phe Leu Asn Lys Ser Glu Glu Trp Ile Arg Lys Met Leu 
    610                 615                 620                 


His Leu Arg Lys Gln Leu Leu Ser Leu Thr Asn Gln Cys Phe Asp Ile 
625                 630                 635                 640 


Glu Glu Glu Val Ser Lys Tyr Gln Glu Tyr Thr Asn Glu Leu Gln Glu 
                645                 650                 655     


Thr Leu Pro Gln Lys Met Phe Thr Ala Ser Ser Gly Ile Lys His Thr 
            660                 665                 670         


Met Thr Pro Ile Tyr Pro Ser Ser Asn Thr Leu Val Glu Met Thr Leu 
        675                 680                 685             


Gly Met Lys Lys Leu Lys Glu Glu Met Glu Gly Val Val Lys Glu Leu 
    690                 695                 700                 


Ala Glu Asn Asn His Ile Leu Glu Arg Phe Gly Ser Leu Thr Met Asp 
705                 710                 715                 720 


Gly Gly Leu Arg Asn Val Asp Cys Leu 
                725                 


<210>  94
<211>  806
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  94

Met Ala Ser Gly Ala Asp Ser Lys Gly Asp Asp Leu Ser Thr Ala Ile 
1               5                   10                  15      


Leu Lys Gln Lys Asn Arg Pro Asn Arg Leu Ile Val Asp Glu Ala Ile 
            20                  25                  30          


Asn Glu Asp Asn Ser Val Val Ser Leu Ser Gln Pro Lys Met Asp Glu 
        35                  40                  45              


Leu Gln Leu Phe Arg Gly Asp Thr Val Leu Leu Lys Gly Lys Lys Arg 
    50                  55                  60                  


Arg Glu Ala Val Cys Ile Val Leu Ser Asp Asp Thr Cys Ser Asp Glu 
65                  70                  75                  80  


Lys Ile Arg Met Asn Arg Val Val Arg Asn Asn Leu Arg Val Arg Leu 
                85                  90                  95      


Gly Asp Val Ile Ser Ile Gln Pro Cys Pro Asp Val Lys Tyr Gly Lys 
            100                 105                 110         


Arg Ile His Val Leu Pro Ile Asp Asp Thr Val Glu Gly Ile Thr Gly 
        115                 120                 125             


Asn Leu Phe Glu Val Tyr Leu Lys Pro Tyr Phe Leu Glu Ala Tyr Arg 
    130                 135                 140                 


Pro Ile Arg Lys Gly Asp Ile Phe Leu Val Arg Gly Gly Met Arg Ala 
145                 150                 155                 160 


Val Glu Phe Lys Val Val Glu Thr Asp Pro Ser Pro Tyr Cys Ile Val 
                165                 170                 175     


Ala Pro Asp Thr Val Ile His Cys Glu Gly Glu Pro Ile Lys Arg Glu 
            180                 185                 190         


Asp Glu Glu Glu Ser Leu Asn Glu Val Gly Tyr Asp Asp Ile Gly Gly 
        195                 200                 205             


Cys Arg Lys Gln Leu Ala Gln Ile Lys Glu Met Val Glu Leu Pro Leu 
    210                 215                 220                 


Arg His Pro Ala Leu Phe Lys Ala Ile Gly Val Lys Pro Pro Arg Gly 
225                 230                 235                 240 


Ile Leu Leu Tyr Gly Pro Pro Gly Thr Gly Lys Thr Leu Ile Ala Arg 
                245                 250                 255     


Ala Val Ala Asn Glu Thr Gly Ala Phe Phe Phe Leu Ile Asn Gly Pro 
            260                 265                 270         


Glu Ile Met Ser Lys Leu Ala Gly Glu Ser Glu Ser Asn Leu Arg Lys 
        275                 280                 285             


Ala Phe Glu Glu Ala Glu Lys Asn Ala Pro Ala Ile Ile Phe Ile Asp 
    290                 295                 300                 


Glu Leu Asp Ala Ile Ala Pro Lys Arg Glu Lys Thr His Gly Glu Val 
305                 310                 315                 320 


Glu Arg Arg Ile Val Ser Gln Leu Leu Thr Leu Met Asp Gly Leu Lys 
                325                 330                 335     


Gln Arg Ala His Val Ile Val Met Ala Ala Thr Asn Arg Pro Asn Ser 
            340                 345                 350         


Ile Asp Pro Ala Leu Arg Arg Phe Gly Arg Phe Asp Arg Glu Val Asp 
        355                 360                 365             


Ile Gly Ile Pro Asp Ala Thr Gly Arg Leu Glu Ile Leu Gln Ile His 
    370                 375                 380                 


Thr Lys Asn Met Lys Leu Ala Asp Asp Val Asp Leu Glu Gln Val Ala 
385                 390                 395                 400 


Asn Glu Thr His Gly His Val Gly Ala Asp Leu Ala Ala Leu Cys Ser 
                405                 410                 415     


Glu Ala Ala Leu Gln Ala Ile Arg Lys Lys Met Asp Leu Ile Asp Leu 
            420                 425                 430         


Glu Asp Glu Thr Ile Asp Ala Glu Val Met Asn Ser Leu Ala Val Thr 
        435                 440                 445             


Met Asp Asp Phe Arg Trp Ala Leu Ser Gln Ser Asn Pro Ser Ala Leu 
    450                 455                 460                 


Arg Glu Thr Val Val Glu Val Pro Gln Val Thr Trp Glu Asp Ile Gly 
465                 470                 475                 480 


Gly Leu Glu Asp Val Lys Arg Glu Leu Gln Glu Leu Val Gln Tyr Pro 
                485                 490                 495     


Val Glu His Pro Asp Lys Phe Leu Lys Phe Gly Met Thr Pro Ser Lys 
            500                 505                 510         


Gly Val Leu Phe Tyr Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala 
        515                 520                 525             


Lys Ala Ile Ala Asn Glu Cys Gln Ala Asn Phe Ile Ser Ile Lys Gly 
    530                 535                 540                 


Pro Glu Leu Leu Thr Met Trp Phe Gly Glu Ser Glu Ala Asn Val Arg 
545                 550                 555                 560 


Glu Ile Phe Asp Lys Ala Arg Gln Ala Ala Pro Cys Val Leu Phe Phe 
                565                 570                 575     


Asp Glu Leu Asp Ser Ile Ala Lys Ala Arg Gly Gly Asn Ile Gly Asp 
            580                 585                 590         


Gly Gly Gly Ala Ala Asp Arg Val Ile Asn Gln Ile Leu Thr Glu Met 
        595                 600                 605             


Asp Gly Met Ser Thr Lys Lys Asn Val Phe Ile Ile Gly Ala Thr Asn 
    610                 615                 620                 


Arg Pro Asp Ile Ile Asp Pro Ala Ile Leu Arg Pro Gly Arg Leu Asp 
625                 630                 635                 640 


Gln Leu Ile Tyr Ile Pro Leu Pro Asp Glu Lys Ser Arg Val Ala Ile 
                645                 650                 655     


Leu Lys Ala Asn Leu Arg Lys Ser Pro Val Ala Lys Asp Val Asp Leu 
            660                 665                 670         


Glu Phe Leu Ala Lys Met Thr Asn Gly Phe Ser Gly Ala Asp Leu Thr 
        675                 680                 685             


Glu Ile Cys Gln Arg Ala Cys Lys Leu Ala Ile Arg Glu Ser Ile Glu 
    690                 695                 700                 


Ser Glu Ile Arg Arg Glu Arg Glu Arg Gln Thr Asn Pro Ser Ala Met 
705                 710                 715                 720 


Glu Val Glu Glu Asp Asp Pro Val Pro Glu Ile Arg Arg Asp His Phe 
                725                 730                 735     


Glu Glu Ala Met Arg Phe Ala Arg Arg Ser Val Ser Asp Asn Asp Ile 
            740                 745                 750         


Arg Lys Tyr Glu Met Phe Ala Gln Thr Leu Gln Gln Ser Arg Gly Phe 
        755                 760                 765             


Gly Ser Phe Arg Phe Pro Ser Gly Asn Gln Gly Gly Ala Gly Pro Ser 
    770                 775                 780                 


Gln Gly Ser Gly Gly Gly Thr Gly Gly Ser Val Tyr Thr Glu Asp Asn 
785                 790                 795                 800 


Asp Asp Asp Leu Tyr Gly 
                805     


<210>  95
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  95

Met Ala Ser Asn Asp Tyr Thr Gln Gln Ala Thr Gln Ser Tyr Gly Ala 
1               5                   10                  15      


Tyr Pro Thr Gln Pro Gly Gln Gly Tyr Ser Gln Gln Ser Ser Gln Pro 
            20                  25                  30          


Tyr Gly Gln Gln Ser Tyr Ser Gly Tyr Ser Gln Ser Thr Asp Thr Ser 
        35                  40                  45              


Gly Tyr Gly Gln Ser Ser Tyr Ser Ser Tyr Gly Gln Ser Gln Asn Thr 
    50                  55                  60                  


Gly Tyr Gly Thr Gln Ser Thr Pro Gln Gly Tyr Gly Ser Thr Gly Gly 
65                  70                  75                  80  


Tyr Gly Ser Ser Gln Ser Ser Gln Ser Ser Tyr Gly Gln Gln Ser Ser 
                85                  90                  95      


Tyr Pro Gly Tyr Gly Gln Gln Pro Ala Pro Ser Ser Thr Ser Gly Ser 
            100                 105                 110         


Tyr Gly Ser Ser Ser Gln Ser Ser Ser Tyr Gly Gln Pro Gln Ser Gly 
        115                 120                 125             


Ser Tyr Ser Gln Gln Pro Ser Tyr Gly Gly Gln Gln Gln Ser Tyr Gly 
    130                 135                 140                 


Gln Gln Gln Ser Tyr Asn Pro Pro Gln Gly Tyr Gly Gln Gln Asn Gln 
145                 150                 155                 160 


Tyr Asn Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Asn 
                165                 170                 175     


Tyr Gly Gln Asp Gln Ser Ser Met Ser Ser Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Tyr Gly Asn Gln Asp Gln Ser Gly Gly Gly Gly Ser Gly Gly Tyr 
        195                 200                 205             


Gly Gln Gln Asp Arg Gly Gly Arg Gly Arg Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Gly Tyr Asn Arg Ser Ser Gly Gly Tyr Glu 
225                 230                 235                 240 


Pro Arg Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly Gly Met Gly Gly 
                245                 250                 255     


Ser Asp Arg Gly Gly Phe Asn Lys Phe Gly Gly Pro Arg Asp Gln Gly 
            260                 265                 270         


Ser Arg His Asp Ser Glu Gln Asp Asn Ser Asp Asn Asn Thr Ile Phe 
        275                 280                 285             


Val Gln Gly Leu Gly Glu Asn Val Thr Ile Glu Ser Val Ala Asp Tyr 
    290                 295                 300                 


Phe Lys Gln Ile Gly Ile Ile Lys Thr Asn Lys Lys Thr Gly Gln Pro 
305                 310                 315                 320 


Met Ile Asn Leu Tyr Thr Asp Arg Glu Thr Gly Lys Leu Lys Gly Glu 
                325                 330                 335     


Ala Thr Val Ser Phe Asp Asp Pro Pro Ser Ala Lys Ala Ala Ile Asp 
            340                 345                 350         


Trp Phe Asp Gly Lys Glu Phe Ser Gly Asn Pro Ile Lys Val Ser Phe 
        355                 360                 365             


Ala Thr Arg Arg Ala Asp Phe Asn Arg Gly Gly Gly Asn Gly Arg Gly 
    370                 375                 380                 


Gly Arg Gly Arg Gly Gly Pro Met Gly Arg Gly Gly Tyr Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Arg Gly Gly Phe Pro Ser Gly Gly Gly Gly 
                405                 410                 415     


Gly Gly Gly Gln Gln Arg Ala Gly Asp Trp Lys Cys Pro Asn Pro Thr 
            420                 425                 430         


Cys Glu Asn Met Asn Phe Ser Trp Arg Asn Glu Cys Asn Gln Cys Lys 
        435                 440                 445             


Ala Pro Lys Pro Asp Gly Pro Gly Gly Gly Pro Gly Gly Ser His Met 
    450                 455                 460                 


Gly Gly Asn Tyr Gly Asp Asp Arg Arg Gly Gly Arg Gly Gly Tyr Asp 
465                 470                 475                 480 


Arg Gly Gly Tyr Arg Gly Arg Gly Gly Asp Arg Gly Gly Phe Arg Gly 
                485                 490                 495     


Gly Arg Gly Gly Gly Asp Arg Gly Gly Phe Gly Pro Gly Lys Met Asp 
            500                 505                 510         


Ser Arg Gly Glu His Arg Gln Asp Arg Arg Glu Arg Pro Tyr 
        515                 520                 525     


<210>  96
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  96

Met Ala Ser Leu Phe Lys Lys Lys Thr Val Asp Asp Val Ile Lys Glu 
1               5                   10                  15      


Gln Asn Arg Glu Leu Arg Gly Thr Gln Arg Ala Ile Ile Arg Asp Arg 
            20                  25                  30          


Ala Ala Leu Glu Lys Gln Glu Lys Gln Leu Glu Leu Glu Ile Lys Lys 
        35                  40                  45              


Met Ala Lys Ile Gly Asn Lys Glu Ala Cys Lys Val Leu Ala Lys Gln 
    50                  55                  60                  


Leu Val His Leu Arg Lys Gln Lys Thr Arg Thr Phe Ala Val Ser Ser 
65                  70                  75                  80  


Lys Val Thr Ser Met Ser Thr Gln Thr Lys Val Met Asn Ser Gln Met 
                85                  90                  95      


Lys Met Ala Gly Ala Met Ser Thr Thr Ala Lys Thr Met Gln Ala Val 
            100                 105                 110         


Asn Lys Lys Met Asp Pro Gln Lys Thr Leu Gln Thr Met Gln Asn Phe 
        115                 120                 125             


Gln Lys Glu Asn Met Lys Met Glu Met Thr Glu Glu Met Ile Asn Asp 
    130                 135                 140                 


Thr Leu Asp Asp Ile Phe Asp Gly Ser Asp Asp Glu Glu Glu Ser Gln 
145                 150                 155                 160 


Asp Ile Val Asn Gln Val Leu Asp Glu Ile Gly Ile Glu Ile Ser Gly 
                165                 170                 175     


Lys Met Ala Lys Ala Pro Ser Ala Ala Arg Ser Leu Pro Ser Ala Ser 
            180                 185                 190         


Thr Ser Lys Ala Thr Ile Ser Asp Glu Glu Ile Glu Arg Gln Leu Lys 
        195                 200                 205             


Ala Leu Gly Val Asp 
    210             


<210>  97
<211>  624
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  97

Met Ala Glu Asn Gly Glu Ser Ser Gly Pro Pro Arg Pro Ser Arg Gly 
1               5                   10                  15      


Pro Ala Ala Ala Gln Gly Ser Ala Ala Ala Pro Ala Glu Pro Lys Ile 
            20                  25                  30          


Ile Lys Val Thr Val Lys Thr Pro Lys Glu Lys Glu Glu Phe Ala Val 
        35                  40                  45              


Pro Glu Asn Ser Ser Val Gln Gln Phe Lys Glu Ala Ile Ser Lys Arg 
    50                  55                  60                  


Phe Lys Ser Gln Thr Asp Gln Leu Val Leu Ile Phe Ala Gly Lys Ile 
65                  70                  75                  80  


Leu Lys Asp Gln Asp Thr Leu Ile Gln His Gly Ile His Asp Gly Leu 
                85                  90                  95      


Thr Val His Leu Val Ile Lys Ser Gln Asn Arg Pro Gln Gly Gln Ser 
            100                 105                 110         


Thr Gln Pro Ser Asn Ala Ala Gly Thr Asn Thr Thr Ser Ala Ser Thr 
        115                 120                 125             


Pro Arg Ser Asn Ser Thr Pro Ile Ser Thr Asn Ser Asn Pro Phe Gly 
    130                 135                 140                 


Leu Gly Ser Leu Gly Gly Leu Ala Gly Leu Ser Ser Leu Gly Leu Ser 
145                 150                 155                 160 


Ser Thr Asn Phe Ser Glu Leu Gln Ser Gln Met Gln Gln Gln Leu Met 
                165                 170                 175     


Ala Ser Pro Glu Met Met Ile Gln Ile Met Glu Asn Pro Phe Val Gln 
            180                 185                 190         


Ser Met Leu Ser Asn Pro Asp Leu Met Arg Gln Leu Ile Met Ala Asn 
        195                 200                 205             


Pro Gln Met Gln Gln Leu Ile Gln Arg Asn Pro Glu Ile Ser His Leu 
    210                 215                 220                 


Leu Asn Asn Pro Asp Ile Met Arg Gln Thr Leu Glu Ile Ala Arg Asn 
225                 230                 235                 240 


Pro Ala Met Met Gln Glu Met Met Arg Asn Gln Asp Leu Ala Leu Ser 
                245                 250                 255     


Asn Leu Glu Ser Ile Pro Gly Gly Tyr Asn Ala Leu Arg Arg Met Tyr 
            260                 265                 270         


Thr Asp Ile Gln Glu Pro Met Leu Asn Ala Ala Gln Glu Gln Phe Gly 
        275                 280                 285             


Gly Asn Pro Phe Ala Ser Val Gly Ser Ser Ser Ser Ser Gly Glu Gly 
    290                 295                 300                 


Thr Gln Pro Ser Arg Thr Glu Asn Arg Asp Pro Leu Pro Asn Pro Trp 
305                 310                 315                 320 


Ala Pro Pro Pro Ala Thr Gln Ser Ser Ala Thr Thr Ser Thr Thr Thr 
                325                 330                 335     


Ser Thr Gly Ser Gly Ser Gly Asn Ser Ser Ser Asn Ala Thr Gly Asn 
            340                 345                 350         


Thr Val Ala Ala Ala Asn Tyr Val Ala Ser Ile Phe Ser Thr Pro Gly 
        355                 360                 365             


Met Gln Ser Leu Leu Gln Gln Ile Thr Glu Asn Pro Gln Leu Ile Gln 
    370                 375                 380                 


Asn Met Leu Ser Ala Pro Tyr Met Arg Ser Met Met Gln Ser Leu Ser 
385                 390                 395                 400 


Gln Asn Pro Asp Leu Ala Ala Gln Met Met Leu Asn Ser Pro Leu Phe 
                405                 410                 415     


Thr Ala Asn Pro Gln Leu Gln Glu Gln Met Arg Pro Gln Leu Pro Ala 
            420                 425                 430         


Phe Leu Gln Gln Met Gln Asn Pro Asp Thr Leu Ser Ala Met Ser Asn 
        435                 440                 445             


Pro Arg Ala Met Gln Ala Leu Met Gln Ile Gln Gln Gly Leu Gln Thr 
    450                 455                 460                 


Leu Ala Thr Glu Ala Pro Gly Leu Ile Pro Ser Phe Thr Pro Gly Val 
465                 470                 475                 480 


Gly Val Gly Val Leu Gly Thr Ala Ile Gly Pro Val Gly Pro Val Thr 
                485                 490                 495     


Pro Ile Gly Pro Ile Gly Pro Ile Val Pro Phe Thr Pro Ile Gly Pro 
            500                 505                 510         


Ile Gly Pro Ile Gly Pro Thr Gly Pro Ala Ala Pro Pro Gly Ser Thr 
        515                 520                 525             


Gly Ser Gly Gly Pro Thr Gly Pro Thr Val Ser Ser Ala Ala Pro Ser 
    530                 535                 540                 


Glu Thr Thr Ser Pro Thr Ser Glu Ser Gly Pro Asn Gln Gln Phe Ile 
545                 550                 555                 560 


Gln Gln Met Val Gln Ala Leu Ala Gly Ala Asn Ala Pro Gln Leu Pro 
                565                 570                 575     


Asn Pro Glu Val Arg Phe Gln Gln Gln Leu Glu Gln Leu Asn Ala Met 
            580                 585                 590         


Gly Phe Leu Asn Arg Glu Ala Asn Leu Gln Ala Leu Ile Ala Thr Gly 
        595                 600                 605             


Gly Asp Ile Asn Ala Ala Ile Glu Arg Leu Leu Gly Ser Gln Pro Ser 
    610                 615                 620                 


<210>  98
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  98

Met Pro Arg Gly Ser Arg Ser Ala Ala Ser Arg Pro Ala Ser Arg Pro 
1               5                   10                  15      


Ala Ala Pro Ser Ala His Pro Pro Ala His Pro Pro Pro Ser Ala Ala 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ser Gly Gln Pro Gly Leu Met Ala Gln Met 
        35                  40                  45              


Ala Thr Thr Ala Ala Gly Val Ala Val Gly Ser Ala Val Gly His Val 
    50                  55                  60                  


Met Gly Ser Ala Leu Thr Gly Ala Phe Ser Gly Gly Ser Ser Glu Pro 
65                  70                  75                  80  


Ser Gln Pro Ala Val Gln Gln Ala Pro Thr Pro Ala Ala Pro Gln Pro 
                85                  90                  95      


Leu Gln Met Gly Pro Cys Ala Tyr Glu Ile Arg Gln Phe Leu Asp Cys 
            100                 105                 110         


Ser Thr Thr Gln Ser Asp Leu Ser Leu Cys Glu Gly Phe Ser Glu Ala 
        115                 120                 125             


Leu Lys Gln Cys Lys Tyr Tyr His Gly Leu Ser Ser Leu Pro 
    130                 135                 140         


<210>  99
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  99

Met Gln Ala Pro His Lys Glu His Leu Tyr Lys Leu Leu Val Ile Gly 
1               5                   10                  15      


Asp Leu Gly Val Gly Lys Thr Ser Ile Ile Lys Arg Tyr Val His Gln 
            20                  25                  30          


Asn Phe Ser Ser His Tyr Arg Ala Thr Ile Gly Val Asp Phe Ala Leu 
        35                  40                  45              


Lys Val Leu His Trp Asp Pro Glu Thr Val Val Arg Leu Gln Leu Trp 
    50                  55                  60                  


Asp Ile Ala Gly Gln Glu Arg Phe Gly Asn Met Thr Arg Val Tyr Tyr 
65                  70                  75                  80  


Arg Glu Ala Met Gly Ala Phe Ile Val Phe Asp Val Thr Arg Pro Ala 
                85                  90                  95      


Thr Phe Glu Ala Val Ala Lys Trp Lys Asn Asp Leu Asp Ser Lys Leu 
            100                 105                 110         


Ser Leu Pro Asn Gly Lys Pro Val Ser Val Val Leu Leu Ala Asn Lys 
        115                 120                 125             


Cys Asp Gln Gly Lys Asp Val Leu Met Asn Asn Gly Leu Lys Met Asp 
    130                 135                 140                 


Gln Phe Cys Lys Glu His Gly Phe Val Gly Trp Phe Glu Thr Ser Ala 
145                 150                 155                 160 


Lys Glu Asn Ile Asn Ile Asp Glu Ala Ser Arg Cys Leu Val Lys His 
                165                 170                 175     


Ile Leu Ala Asn Glu Cys Asp Leu Met Glu Ser Ile Glu Pro Asp Val 
            180                 185                 190         


Val Lys Pro His Leu Thr Ser Thr Lys Val Ala Ser Cys Ser Gly Cys 
        195                 200                 205             


Ala Lys Ser 
    210     


<210>  100
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  100

Met Ala Pro Trp Leu Gln Leu Leu Ser Leu Leu Gly Leu Leu Pro Gly 
1               5                   10                  15      


Ala Val Ala Ala Pro Ala Gln Pro Arg Ala Ala Ser Phe Gln Ala Trp 
            20                  25                  30          


Gly Pro Pro Ser Pro Glu Leu Leu Ala Pro Thr Arg Phe Ala Leu Glu 
        35                  40                  45              


Met Phe Asn Arg Gly Arg Ala Ala Gly Thr Arg Ala Val Leu Gly Leu 
    50                  55                  60                  


Val Arg Gly Arg Val Arg Arg Ala Gly Gln Gly Ser Leu Tyr Ser Leu 
65                  70                  75                  80  


Glu Ala Thr Leu Glu Glu Pro Pro Cys Asn Asp Pro Met Val Cys Arg 
                85                  90                  95      


Leu Pro Val Ser Lys Lys Thr Leu Leu Cys Ser Phe Gln Val Leu Asp 
            100                 105                 110         


Glu Leu Gly Arg His Val Leu Leu Arg Lys Asp Cys Gly Pro Val Asp 
        115                 120                 125             


Thr Lys Val Pro Gly Ala Gly Glu Pro Lys Ser Ala Phe Thr Gln Gly 
    130                 135                 140                 


Ser Ala Met Ile Ser Ser Leu Ser Gln Asn His Pro Asp Asn Arg Asn 
145                 150                 155                 160 


Glu Thr Phe Ser Ser Val Ile Ser Leu Leu Asn Glu Asp Pro Leu Ser 
                165                 170                 175     


Gln Asp Leu Pro Val Lys Met Ala Ser Ile Phe Lys Asn Phe Val Ile 
            180                 185                 190         


Thr Tyr Asn Arg Thr Tyr Glu Ser Lys Glu Glu Ala Arg Trp Arg Leu 
        195                 200                 205             


Ser Val Phe Val Asn Asn Met Val Arg Ala Gln Lys Ile Gln Ala Leu 
    210                 215                 220                 


Asp Arg Gly Thr Ala Gln Tyr Gly Val Thr Lys Phe Ser Asp Leu Thr 
225                 230                 235                 240 


Glu Glu Glu Phe Arg Thr Ile Tyr Leu Asn Thr Leu Leu Arg Lys Glu 
                245                 250                 255     


Pro Gly Asn Lys Met Lys Gln Ala Lys Ser Val Gly Asp Leu Ala Pro 
            260                 265                 270         


Pro Glu Trp Asp Trp Arg Ser Lys Gly Ala Val Thr Lys Val Lys Asp 
        275                 280                 285             


Gln Gly Met Cys Gly Ser Cys Trp Ala Phe Ser Val Thr Gly Asn Val 
    290                 295                 300                 


Glu Gly Gln Trp Phe Leu Asn Gln Gly Thr Leu Leu Ser Leu Ser Glu 
305                 310                 315                 320 


Gln Glu Leu Leu Asp Cys Asp Lys Met Asp Lys Ala Cys Met Gly Gly 
                325                 330                 335     


Leu Pro Ser Asn Ala Tyr Ser Ala Ile Lys Asn Leu Gly Gly Leu Glu 
            340                 345                 350         


Thr Glu Asp Asp Tyr Ser Tyr Gln Gly His Met Gln Ser Cys Asn Phe 
        355                 360                 365             


Ser Ala Glu Lys Ala Lys Val Tyr Ile Asn Asp Ser Val Glu Leu Ser 
    370                 375                 380                 


Gln Asn Glu Gln Lys Leu Ala Ala Trp Leu Ala Lys Arg Gly Pro Ile 
385                 390                 395                 400 


Ser Val Ala Ile Asn Ala Phe Gly Met Gln Phe Tyr Arg His Gly Ile 
                405                 410                 415     


Ser Arg Pro Leu Arg Pro Leu Cys Ser Pro Trp Leu Ile Asp His Ala 
            420                 425                 430         


Val Leu Leu Val Gly Tyr Gly Asn Arg Ser Asp Val Pro Phe Trp Ala 
        435                 440                 445             


Ile Lys Asn Ser Trp Gly Thr Asp Trp Gly Glu Lys Gly Tyr Tyr Tyr 
    450                 455                 460                 


Leu His Arg Gly Ser Gly Ala Cys Gly Val Asn Thr Met Ala Ser Ser 
465                 470                 475                 480 


Ala Val Val Asp 
                


<210>  101
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  101

Met Ala Ala Leu Gly Cys Ala Arg Leu Arg Trp Ala Leu Arg Gly Ala 
1               5                   10                  15      


Gly Arg Gly Leu Cys Pro His Gly Ala Arg Ala Lys Ala Ala Ile Pro 
            20                  25                  30          


Ala Ala Leu Pro Ser Asp Lys Ala Thr Gly Ala Pro Gly Ala Gly Pro 
        35                  40                  45              


Gly Val Arg Arg Arg Gln Arg Ser Leu Glu Glu Ile Pro Arg Leu Gly 
    50                  55                  60                  


Gln Leu Arg Phe Phe Phe Gln Leu Phe Val Gln Gly Tyr Ala Leu Gln 
65                  70                  75                  80  


Leu His Gln Leu Gln Val Leu Tyr Lys Ala Lys Tyr Gly Pro Met Trp 
                85                  90                  95      


Met Ser Tyr Leu Gly Pro Gln Met His Val Asn Leu Ala Ser Ala Pro 
            100                 105                 110         


Leu Leu Glu Gln Val Met Arg Gln Glu Gly Lys Tyr Pro Val Arg Asn 
        115                 120                 125             


Asp Met Glu Leu Trp Lys Glu His Arg Asp Gln His Asp Leu Thr Tyr 
    130                 135                 140                 


Gly Pro Phe Thr Thr Glu Gly His His Trp Tyr Gln Leu Arg Gln Ala 
145                 150                 155                 160 


Leu Asn Gln Arg Leu Leu Lys Pro Ala Glu Ala Ala Leu Tyr Thr Asp 
                165                 170                 175     


Ala Phe Asn Glu Val Ile Asp Asp Phe Met Thr Arg Leu Asp Gln Leu 
            180                 185                 190         


Arg Ala Glu Ser Ala Ser Gly Asn Gln Val Ser Asp Met Ala Gln Leu 
        195                 200                 205             


Phe Tyr Tyr Phe Ala Leu Glu Ala Ile Cys Tyr Ile Leu Phe Glu Lys 
    210                 215                 220                 


Arg Ile Gly Cys Leu Gln Arg Ser Ile Pro Glu Asp Thr Val Thr Phe 
225                 230                 235                 240 


Val Arg Ser Ile Gly Leu Met Phe Gln Asn Ser Leu Tyr Ala Thr Phe 
                245                 250                 255     


Leu Pro Lys Trp Thr Arg Pro Val Leu Pro Phe Trp Lys Arg Tyr Leu 
            260                 265                 270         


Asp Gly Trp Asn Ala Ile Phe Ser Phe Gly Lys Lys Leu Ile Asp Glu 
        275                 280                 285             


Lys Leu Glu Asp Met Glu Ala Gln Leu Gln Ala Ala Gly Pro Asp Gly 
    290                 295                 300                 


Ile Gln Val Ser Gly Tyr Leu His Phe Leu Leu Ala Ser Gly Gln Leu 
305                 310                 315                 320 


Ser Pro Arg Glu Ala Met Gly Ser Leu Pro Glu Leu Leu Met Ala Gly 
                325                 330                 335     


Val Asp Thr Thr Ser Asn Thr Leu Thr Trp Ala Leu Tyr His Leu Ser 
            340                 345                 350         


Lys Asp Pro Glu Ile Gln Glu Ala Leu His Glu Glu Val Val Gly Val 
        355                 360                 365             


Val Pro Ala Gly Gln Val Pro Gln His Lys Asp Phe Ala His Met Pro 
    370                 375                 380                 


Leu Leu Lys Ala Val Leu Lys Glu Thr Leu Arg Leu Tyr Pro Val Val 
385                 390                 395                 400 


Pro Thr Asn Ser Arg Ile Ile Glu Lys Glu Ile Glu Val Asp Gly Phe 
                405                 410                 415     


Leu Phe Pro Lys Asn Thr Gln Phe Val Phe Cys His Tyr Val Val Ser 
            420                 425                 430         


Arg Asp Pro Thr Ala Phe Ser Glu Pro Glu Ser Phe Gln Pro His Arg 
        435                 440                 445             


Trp Leu Arg Asn Ser Gln Pro Ala Thr Pro Arg Ile Gln His Pro Phe 
    450                 455                 460                 


Gly Ser Val Pro Phe Gly Tyr Gly Val Arg Ala Cys Leu Gly Arg Arg 
465                 470                 475                 480 


Ile Ala Glu Leu Glu Met Gln Leu Leu Leu Ala Arg Leu Ile Gln Lys 
                485                 490                 495     


Tyr Lys Val Val Leu Ala Pro Glu Thr Gly Glu Leu Lys Ser Val Ala 
            500                 505                 510         


Arg Ile Val Leu Val Pro Asn Lys Lys Val Gly Leu Gln Phe Leu Gln 
        515                 520                 525             


Arg Gln Cys 
    530     


<210>  102
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  102

Met Val Asp Phe Pro Gly Tyr Asn Leu Ser Gly Ala Val Ala Ser Phe 
1               5                   10                  15      


Leu Phe Ile Leu Leu Thr Met Lys Gln Ser Glu Asp Phe Arg Val Ile 
            20                  25                  30          


Gly Pro Ala His Pro Ile Leu Ala Gly Val Gly Glu Asp Ala Leu Leu 
        35                  40                  45              


Thr Cys Gln Leu Leu Pro Lys Arg Thr Thr Met His Val Glu Val Arg 
    50                  55                  60                  


Trp Tyr Arg Ser Glu Pro Ser Thr Pro Val Phe Val His Arg Asp Gly 
65                  70                  75                  80  


Val Glu Val Thr Glu Met Gln Met Glu Glu Tyr Arg Gly Trp Val Glu 
                85                  90                  95      


Trp Ile Glu Asn Gly Ile Ala Lys Gly Asn Val Ala Leu Lys Ile His 
            100                 105                 110         


Asn Ile Gln Pro Ser Asp Asn Gly Gln Tyr Trp Cys His Phe Gln Asp 
        115                 120                 125             


Gly Asn Tyr Cys Gly Glu Thr Ser Leu Leu Leu Lys Val Ala Gly Leu 
    130                 135                 140                 


Gly Ser Ala Pro Ser Ile His Met Glu Gly Pro Gly Glu Ser Gly Val 
145                 150                 155                 160 


Gln Leu Val Cys Thr Ala Arg Gly Trp Phe Pro Glu Pro Gln Val Tyr 
                165                 170                 175     


Trp Glu Asp Ile Arg Gly Glu Lys Leu Leu Ala Val Ser Glu His Arg 
            180                 185                 190         


Ile Gln Asp Lys Asp Gly Leu Phe Tyr Ala Glu Ala Thr Leu Val Val 
        195                 200                 205             


Arg Asn Ala Ser Ala Glu Ser Val Ser Cys Leu Val His Asn Pro Val 
    210                 215                 220                 


Leu Thr Glu Glu Lys Gly Ser Val Ile Ser Leu Pro Glu Lys Leu Gln 
225                 230                 235                 240 


Thr Glu Leu Ala Ser Leu Lys Val Asn Gly Pro Ser Gln Pro Ile Leu 
                245                 250                 255     


Val Arg Val Gly Glu Asp Ile Gln Leu Thr Cys Tyr Leu Ser Pro Lys 
            260                 265                 270         


Ala Asn Ala Gln Ser Met Glu Val Arg Trp Asp Arg Ser His Arg Tyr 
        275                 280                 285             


Pro Ala Val His Val Tyr Met Asp Gly Asp His Val Ala Gly Glu Gln 
    290                 295                 300                 


Met Ala Glu Tyr Arg Gly Arg Thr Val Leu Val Ser Asp Ala Ile Asp 
305                 310                 315                 320 


Glu Gly Arg Leu Thr Leu Gln Ile Leu Ser Ala Arg Pro Ser Asp Asp 
                325                 330                 335     


Gly Gln Tyr Arg Cys Leu Phe Glu Lys Asp Asp Val Tyr Gln Glu Ala 
            340                 345                 350         


Ser Leu Asp Leu Lys Val Val Ser Leu Gly Ser Ser Pro Leu Ile Thr 
        355                 360                 365             


Val Glu Gly Gln Glu Asp Gly Glu Met Gln Pro Met Cys Ser Ser Asp 
    370                 375                 380                 


Gly Trp Phe Pro Gln Pro His Val Pro Trp Arg Asp Met Glu Gly Lys 
385                 390                 395                 400 


Thr Ile Pro Ser Ser Ser Gln Ala Leu Thr Gln Gly Ser His Gly Leu 
                405                 410                 415     


Phe His Val Gln Thr Leu Leu Arg Val Thr Asn Ile Ser Ala Val Asp 
            420                 425                 430         


Val Thr Cys Ser Ile Ser Ile Pro Phe Leu Gly Glu Glu Lys Ile Ala 
        435                 440                 445             


Thr Phe Ser Leu Ser Gly Trp 
    450                 455 


<210>  103
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  103

Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
145                 150                 155                 160 


Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser Ile Leu 
                165                 170                 175     


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
            180                 185                 190         


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
        195                 200                 205             


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
    210                 215                 220                 


Pro Gly Leu Arg Asp Thr 
225                 230 


<210>  104
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  104

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  105
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  105

Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg 
    210                 215                 220                 


Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly 
225                 230                 235                 240 


Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu 
                245                 250                 255     


Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 
            260                 265                 270         


Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 
        275                 280                 285             


Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 
    290                 295                 300                 


Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
305                 310                 315         


<210>  106
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  106

Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
145                 150                 155                 160 


Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
                165                 170                 175     


Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro 
            180                 185                 190         


Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys 
        195                 200                 205             


Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu 
    210                 215                 220                 


Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys 
225                 230                 235                 240 


Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile 
                245                 250                 255     


Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr 
            260                 265                 270         


Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val 
        275                 280                 285             


Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp 
    290                 295                 300                 


Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His 
305                 310                 315                 320 


Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
                325                 330                 335     


Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu 
            340                 345                 350         


Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn 
        355                 360                 365             


Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly 
    370                 375                 380                 


Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His 
385                 390                 395                 400 


Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys 
                405                 410                 415     


Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg 
            420                 425                 430         


Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr 
        435                 440                 445             


Ser Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp 
    450                 455                 460                 


Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His 
465                 470                 475                 480 


Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu 
                485                 490                 495     


Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro 
            500                 505                 510         


His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His 
        515                 520                 525             


Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys 
    530                 535                 540                 


Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro 
545                 550                 555                 560 


Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu 
                565                 570                 575     


Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu 
            580                 585                 590         


Leu 
    


