                         SEQUENCE LISTING

<110>  Baxalta Incorporated
       Baxalta GmbH
       Rottensteiner, Hanspeter       
       Horling, Franziska
       Lengler, Johannes       
       Scheiflinger, Friedrich
 
<120>  GENE THERAPY OF HEMOPHILIA B USING VIRAL VECTORS ENCODING RECOMBINANT FIX VARIANTS WITH INCREASED EXPRESSION

<130>  008073-5209-WO

<150>  US 62/800,338
<151>  2019-02-01

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FIX-FL-NA

<400>  1
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta       60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt      120

ctgaatcggc caaagaggta taattcaggt aaattggaag agtttgttca agggaacctt      180

gagagagaat gtatggaaga aaagtgtagt tttgaagaag cacgagaagt ttttgaaaac      240

actgaaagaa caactgaatt ttggaagcag tatgttgatg gagatcagtg tgagtccaat      300

ccatgtttaa atggcggcag ttgcaaggat gacattaatt cctatgaatg ttggtgtccc      360

tttggatttg aaggaaagaa ctgtgaatta gatgtaacat gtaacattaa gaatggcaga      420

tgcgagcagt tttgtaaaaa tagtgctgat aacaaggtgg tttgctcctg tactgaggga      480

tatcgacttg cagaaaacca gaagtcctgt gaaccagcag tgccatttcc atgtggaaga      540

gtttctgttt cacaaacttc taagctcacc cgtgctgaga ctgtttttcc tgatgtggac      600

tatgtaaatt ctactgaagc tgaaaccatt ttggataaca tcactcaaag cacccaatca      660

tttaatgact tcactcgggt tgttggtgga gaagatgcca aaccaggtca attcccttgg      720

caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa      780

tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt      840

gaacataata ttgaggagac agaacataca gagcaaaagc gaaatgtgat tcgaattatt      900

cctcaccaca actacaatgc agctattaat aagtacaacc atgacattgc ccttctggaa      960

ctggacgaac ccttagtgct aaacagctac gttacaccta tttgcattgc tgacaaggaa     1020

tacacgaaca tcttcctcaa atttggatct ggctatgtaa gtggctgggg aagagtcttc     1080

cacaaaggga gatcagcttt agttcttcag taccttagag ttccacttgt tgaccgagcc     1140

acatgtcttc gatctacaaa gttcaccatc tataacaaca tgttctgtgc tggcttccat     1200

gaaggaggta gagattcatg tcaaggagat agtgggggac cccatgttac tgaagtggaa     1260

gggaccagtt tcttaactgg aattattagc tggggtgaag agtgtgcaat gaaaggcaaa     1320

tatggaatat ataccaaggt atcccggtat gtcaactgga ttaaggaaaa aacaaagctc     1380

acttaa                                                                1386


<210>  2
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX-FL-AA

<400>  2

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  3
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX2-FL-AA

<400>  3

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Val Thr Cys 
                85                  90                  95      


Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe Cys Lys Asn Ser Ala Asp 
            100                 105                 110         


Asn Lys Val Val Cys Ser Cys Thr Glu Gly Tyr Arg Leu Ala Glu Asn 
        115                 120                 125             


Gln Lys Ser Cys Glu Pro Ala Val Pro Phe Pro Cys Gly Arg Val Ser 
    130                 135                 140                 


Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro Asp 
145                 150                 155                 160 


Val Asp Tyr Val Asn Ser Thr Glu Ala Glu Thr Ile Leu Asp Asn Ile 
                165                 170                 175     


Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe Thr Arg Val Val Gly Gly 
            180                 185                 190         


Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp Gln Val Val Leu Asn Gly 
        195                 200                 205             


Lys Val Asp Ala Phe Cys Gly Gly Ser Ile Val Asn Glu Lys Trp Ile 
    210                 215                 220                 


Val Thr Ala Ala His Cys Val Glu Thr Gly Val Lys Ile Thr Val Val 
225                 230                 235                 240 


Ala Gly Glu His Asn Ile Glu Glu Thr Glu His Thr Glu Gln Lys Arg 
                245                 250                 255     


Asn Val Ile Arg Ile Ile Pro His His Asn Tyr Asn Ala Ala Ile Asn 
            260                 265                 270         


Lys Tyr Asn His Asp Ile Ala Leu Leu Glu Leu Asp Glu Pro Leu Val 
        275                 280                 285             


Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile Ala Asp Lys Glu Tyr Thr 
    290                 295                 300                 


Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr Val Ser Gly Trp Gly Arg 
305                 310                 315                 320 


Val Phe His Lys Gly Arg Ser Ala Leu Val Leu Gln Tyr Leu Arg Val 
                325                 330                 335     


Pro Leu Val Asp Arg Ala Thr Cys Leu Arg Ser Thr Lys Phe Thr Ile 
            340                 345                 350         


Tyr Asn Asn Met Phe Cys Ala Gly Phe His Glu Gly Gly Arg Asp Ser 
        355                 360                 365             


Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Glu Val Glu Gly Thr 
    370                 375                 380                 


Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly Glu Glu Cys Ala Met Lys 
385                 390                 395                 400 


Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser Arg Tyr Val Asn Trp Ile 
                405                 410                 415     


Lys Glu Lys Thr Lys Leu Thr 
            420             


<210>  4
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIXp-FL-AA

<400>  4

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Leu 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  5
<211>  1385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS02-FL-NA

<400>  5
atgcagaggg tgaacatgat catggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtcagcaga gtgcacagtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagagata caactcaggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgcagc tttgaggagg ccagagaggt gtttgagaac      240

acagagagga ccacagagtt ctggaagcag tatgtggatg gagaccagtg tgagagcaac      300

ccttgcctga atggaggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgccct      360

tttggctttg agggcaagaa ctgtgagctg gatgtgacct gcaacatcaa gaatggcagg      420

tgtgagcagt tctgcaagaa ctcagctgac aacaaagtgg tgtgtagctg cacagagggc      480

tacagactgg ctgagaacca gaagagctgt gagcctgctg tgcccttccc ctgtggcaga      540

gtgtcagtgt cccagaccag caagctgacc agagctgaga cagtgttccc tgatgtggac      600

tatgtgaata gcacagaggc tgagaccatc ctggacaaca tcacccagag cacccagtcc      660

ttcaatgact tcaccagagt tgtgggagga gaggatgcca agcctggcca gttcccctgg      720

caggtggtgc tgaatggcaa agtggatgcc ttctgtggag gcagcattgt gaatgagaag      780

tggattgtga cagctgccca ctgtgtggag acaggagtga agatcacagt ggtggctgga      840

gaacacaata ttgaggagac agagcacaca gagcagaaga ggaatgtcat caggattatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggatgagc ctctggtgct gaatagctat gtgaccccca tctgcattgc tgacaaggag     1020

tacaccaaca tcttcctgaa gtttggctca ggctatgtgt caggctgggg cagagtgttc     1080

cacaagggca gatcagccct ggtgctgcag tacctgagag tgcccctggt ggacagagcc     1140

acctgcctgt tgagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gagggaggca gagacagctg ccagggagac tcaggaggac cccatgtgac agaagtggag     1260

ggcaccagct tcctgacagg catcatcagc tggggagagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaagt gagcagatat gtgaactgga tcaaggagaa aaccaagctg     1380

acctg                                                                 1385


<210>  6
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS03-FL-NA

<400>  6
atgcagaggg tgaacatgat catggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcactgtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagagata caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgcagc tttgaggagg ccagggaagt gtttgagaac      240

actgagagga ccactgagtt ctggaagcag tatgtggatg gggaccagtg tgagagcaac      300

ccttgcctga atgggggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgccct      360

tttggctttg agggcaagaa ctgtgagctg gatgtgacct gcaacatcaa gaatggcagg      420

tgtgagcagt tctgcaagaa ctctgctgac aacaaagtgg tgtgtagctg cactgagggc      480

tacagactgg ctgagaacca gaagagctgt gagcctgctg tgcccttccc ctgtggcaga      540

gtgtctgtgt cccagaccag caagctgacc agagctgaga ctgtgttccc tgatgtggac      600

tatgtgaata gcactgaggc tgagaccatc ctggacaaca tcacccagag cacccagtcc      660

ttcaatgact tcaccagagt ggtggggggg gaggatgcca agcctggcca gttcccctgg      720

caggtggtgc tgaatggcaa agtggatgcc ttctgtgggg gcagcattgt gaatgagaag      780

tggattgtga ctgctgccca ctgtgtggag actggggtga agatcactgt ggtggctggg      840

gaacacaata ttgaggagac tgagcacact gagcagaaga ggaatgtcat caggattatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggatgagc ctctggtgct gaatagctat gtgaccccca tctgcattgc tgacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt ctggctgggg cagagtgttc     1080

cacaagggca ggtctgccct ggtgctgcag tacctgagag tgcccctggt ggacagagcc     1140

acctgcctgc tgagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gaggggggca gagacagctg ccagggggac tctgggggcc cccatgtgac tgaagtggag     1260

ggcaccagct tcctgactgg catcatcagc tggggggagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaagt gagcaggtat gtgaactgga tcaaggagaa aaccaagctg     1380

acctga                                                                1386


<210>  7
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS04-FL-NA

<400>  7
atgcagaggg tgaacatgat tatggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcacagtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagagata caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgcagc tttgaggagg ccagggaggt gtttgagaac      240

acagagagga ccacagagtt ctggaagcag tatgtggatg gtgaccagtg tgagagcaac      300

ccttgcctga atggaggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgccct      360

tttggctttg agggcaagaa ctgtgagctg gatgtgacct gcaacatcaa gaatggcagg      420

tgtgagcagt tctgcaagaa ctctgctgac aacaaggtgg tgtgtagctg cacagagggc      480

tacagactgg ctgagaacca gaagagctgt gagcctgctg tgcccttccc ctgtggcaga      540

gtgtctgtgt cccagaccag caagctgacc agagctgaga cagtgttccc tgatgtggac      600

tatgtgaaca gcacagaggc tgagaccatc ctggacaaca tcacccagag cacccagtcc      660

ttcaatgact tcaccagagt ggtgggagga gaggatgcca agcctggcca gttcccctgg      720

caggtggtgc tgaatggcaa ggtggatgcc ttctgtggag gcagcattgt gaatgagaag      780

tggattgtga cagctgccca ctgtgtggag acaggagtga agatcacagt ggtggctgga      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtgat caggatcatc      900

cctcaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggatgagc ctctggtgct gaacagctat gtgaccccta tctgcattgc tgacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt ctggctgggg cagagtgttc     1080

cacaagggca ggtctgccct ggtgctgcag tacctgagag tgcccctggt ggacagagcc     1140

acctgcctgt tgagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gagggaggca gagacagctg ccagggtgac tctggaggac cccatgtgac agaggtggag     1260

ggcaccagct tcctgacagg catcatcagc tggggagagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaagt gagcagatat gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  8
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS05-FL-NA

<400>  8
atgcagaggg tgaacatgat tatggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcactgtg ttcctggacc atgagaatgc caacaagatc      120

ctgaaccgcc ccaagcgcta caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgcagc tttgaggagg ccagggaggt gtttgagaac      240

actgagcgca ccactgagtt ctggaagcag tatgtggatg gggaccagtg tgagagcaac      300

ccctgcctga atggggggag ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgtgacct gcaacatcaa gaatggccgc      420

tgtgagcagt tctgcaagaa ctctgctgac aacaaggtgg tgtgctcttg cactgagggc      480

taccgcctgg ctgagaacca gaagagctgt gagcctgctg tgcccttccc ctgtggcagg      540

gtgtctgtga gccagaccag caagctgacc agggctgaga ctgtgttccc tgacgtggac      600

tatgtgaaca gcactgaggc tgagaccatc ctggacaaca tcacccagag cacccagagc      660

ttcaatgact tcaccagggt ggtgggagga gaggatgcca agcctggcca gttcccctgg      720

caggtggtgc tgaatggcaa ggtggatgcc ttctgtggag gcagcattgt gaatgagaag      780

tggattgtga ccgctgccca ctgtgtggag actggagtga agatcactgt ggtggctggg      840

gagcacaaca ttgaggagac agagcacaca gagcagaagc gcaatgtgat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggatgagc ccctggtgct gaacagctac gtgaccccca tctgcattgc agacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt ctggctgggg cagggtgttc     1080

cacaagggca ggtctgccct ggtgctgcag tacctgaggg tgcccctggt ggacagggcc     1140

acctgcctgc tgagcaccaa gttcaccatc tacaacaaca tgttctgcgc tggcttccat     1200

gagggaggaa gggacagctg ccagggagac tctggaggcc cccatgtgac agaggtggag     1260

ggcaccagct tcctgacagg catcatcagc tggggggagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaagt gtcccgctat gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  9
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS06-FL-NA

<400>  9
atgcagaggg tcaacatgat catggctgag tcccctggcc tcatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcactgtc ttcctggacc atgagaatgc caacaagatc      120

ctcaacaggc ccaagagata caactctggc aaactggagg agtttgtcca gggcaacctg      180

gagagggagt gcatggagga gaagtgctcc tttgaggagg ccagggaggt ctttgagaac      240

actgagcgca ccactgagtt ctggaaacag tatgtggatg gggaccagtg tgagtccaac      300

ccctgcctga atgggggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgtgacct gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa ctctgctgac aacaaggtgg tgtgctcctg cactgagggc      480

taccgcctgg ctgagaacca gaagagctgt gagcctgctg tgccattccc atgtggcaga      540

gtctctgtga gccagaccag caagctcacc agggctgaga ctgtgttccc tgatgtggac      600

tatgtgaaca gcactgaggc tgaaaccatc ctggacaaca tcacccagag cacccagagc      660

ttcaatgact tcaccagagt ggtgggagga gaggatgcca agcctggcca gttcccctgg      720

caagtggtgc tcaatggcaa ggtggatgcc ttctgtgggg gctccattgt gaatgagaag      780

tggattgtca ctgctgccca ctgtgtggag actggggtca agatcactgt ggtggctggg      840

gagcacaaca ttgaggagac tgagcacact gagcagaagc gcaatgtgat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggatgagc ccctggtcct caacagctat gtgaccccca tctgcattgc tgacaaggag     1020

tacaccaaca tcttcctcaa gtttggctct ggctatgtct ctggctgggg cagagtgttc     1080

cacaaaggca ggtctgccct ggtgctccag tacctgagag tgcccctggt ggacagggcc     1140

acctgcctct tgagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gagggaggaa gagacagctg ccagggggac tctggaggac cccatgtcac tgaggtggag     1260

ggcacctcct tcctcactgg catcatctcc tggggagagg agtgtgccat gaaaggcaaa     1320

tatggcatct acaccaaagt ctccagatat gtcaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  10
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX-MP-AA

<400>  10

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  11
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX2-MP-AA

<400>  11

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Val 
        35                  40                  45              


Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe Cys Lys Asn Ser 
    50                  55                  60                  


Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly Tyr Arg Leu Ala 
65                  70                  75                  80  


Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe Pro Cys Gly Arg 
                85                  90                  95      


Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe 
            100                 105                 110         


Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu Thr Ile Leu Asp 
        115                 120                 125             


Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe Thr Arg Val Val 
    130                 135                 140                 


Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp Gln Val Val Leu 
145                 150                 155                 160 


Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile Val Asn Glu Lys 
                165                 170                 175     


Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly Val Lys Ile Thr 
            180                 185                 190         


Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu His Thr Glu Gln 
        195                 200                 205             


Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn Tyr Asn Ala Ala 
    210                 215                 220                 


Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu Leu Asp Glu Pro 
225                 230                 235                 240 


Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile Ala Asp Lys Glu 
                245                 250                 255     


Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr Val Ser Gly Trp 
            260                 265                 270         


Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val Leu Gln Tyr Leu 
        275                 280                 285             


Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg Ser Thr Lys Phe 
    290                 295                 300                 


Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His Glu Gly Gly Arg 
305                 310                 315                 320 


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Glu Val Glu 
                325                 330                 335     


Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly Glu Glu Cys Ala 
            340                 345                 350         


Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser Arg Tyr Val Asn 
        355                 360                 365             


Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    370                 375         


<210>  12
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIXp-MP-AA

<400>  12

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Leu Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Leu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  13
<211>  1248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS02-MP-NA

<400>  13
tacaactcag gcaagctgga ggagtttgtg cagggcaacc tggagaggga gtgcatggag       60

gagaagtgca gctttgagga ggccagagag gtgtttgaga acacagagag gaccacagag      120

ttctggaagc agtatgtgga tggagaccag tgtgagagca acccttgcct gaatggaggc      180

agctgcaagg atgacatcaa cagctatgag tgctggtgcc cttttggctt tgagggcaag      240

aactgtgagc tggatgtgac ctgcaacatc aagaatggca ggtgtgagca gttctgcaag      300

aactcagctg acaacaaagt ggtgtgtagc tgcacagagg gctacagact ggctgagaac      360

cagaagagct gtgagcctgc tgtgcccttc ccctgtggca gagtgtcagt gtcccagacc      420

agcaagctga ccagagctga gacagtgttc cctgatgtgg actatgtgaa tagcacagag      480

gctgagacca tcctggacaa catcacccag agcacccagt ccttcaatga cttcaccaga      540

gttgtgggag gagaggatgc caagcctggc cagttcccct ggcaggtggt gctgaatggc      600

aaagtggatg ccttctgtgg aggcagcatt gtgaatgaga agtggattgt gacagctgcc      660

cactgtgtgg agacaggagt gaagatcaca gtggtggctg gagaacacaa tattgaggag      720

acagagcaca cagagcagaa gaggaatgtc atcaggatta tcccccacca caactacaat      780

gctgccatca acaagtacaa ccatgacatt gccctgctgg agctggatga gcctctggtg      840

ctgaatagct atgtgacccc catctgcatt gctgacaagg agtacaccaa catcttcctg      900

aagtttggct caggctatgt gtcaggctgg ggcagagtgt tccacaaggg cagatcagcc      960

ctggtgctgc agtacctgag agtgcccctg gtggacagag ccacctgcct gttgagcacc     1020

aagttcacca tctacaacaa catgttctgt gctggcttcc atgagggagg cagagacagc     1080

tgccagggag actcaggagg accccatgtg acagaagtgg agggcaccag cttcctgaca     1140

ggcatcatca gctggggaga ggagtgtgcc atgaagggca agtatggcat ctacaccaaa     1200

gtgagcagat atgtgaactg gatcaaggag aaaaccaagc tgacctga                  1248


<210>  14
<211>  1248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS03-MP-NA

<400>  14
tacaactctg gcaagctgga ggagtttgtg cagggcaacc tggagaggga gtgcatggag       60

gagaagtgca gctttgagga ggccagggaa gtgtttgaga acactgagag gaccactgag      120

ttctggaagc agtatgtgga tggggaccag tgtgagagca acccttgcct gaatgggggc      180

agctgcaagg atgacatcaa cagctatgag tgctggtgcc cttttggctt tgagggcaag      240

aactgtgagc tggatgtgac ctgcaacatc aagaatggca ggtgtgagca gttctgcaag      300

aactctgctg acaacaaagt ggtgtgtagc tgcactgagg gctacagact ggctgagaac      360

cagaagagct gtgagcctgc tgtgcccttc ccctgtggca gagtgtctgt gtcccagacc      420

agcaagctga ccagagctga gactgtgttc cctgatgtgg actatgtgaa tagcactgag      480

gctgagacca tcctggacaa catcacccag agcacccagt ccttcaatga cttcaccaga      540

gtggtggggg gggaggatgc caagcctggc cagttcccct ggcaggtggt gctgaatggc      600

aaagtggatg ccttctgtgg gggcagcatt gtgaatgaga agtggattgt gactgctgcc      660

cactgtgtgg agactggggt gaagatcact gtggtggctg gggaacacaa tattgaggag      720

actgagcaca ctgagcagaa gaggaatgtc atcaggatta tcccccacca caactacaat      780

gctgccatca acaagtacaa ccatgacatt gccctgctgg agctggatga gcctctggtg      840

ctgaatagct atgtgacccc catctgcatt gctgacaagg agtacaccaa catcttcctg      900

aagtttggct ctggctatgt gtctggctgg ggcagagtgt tccacaaggg caggtctgcc      960

ctggtgctgc agtacctgag agtgcccctg gtggacagag ccacctgcct gctgagcacc     1020

aagttcacca tctacaacaa catgttctgt gctggcttcc atgagggggg cagagacagc     1080

tgccaggggg actctggggg cccccatgtg actgaagtgg agggcaccag cttcctgact     1140

ggcatcatca gctgggggga ggagtgtgcc atgaagggca agtatggcat ctacaccaaa     1200

gtgagcaggt atgtgaactg gatcaaggag aaaaccaagc tgacctga                  1248


<210>  15
<211>  1250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS04-MP-NA

<400>  15
cstacaactc tggcaagctg gaggagtttg tgcagggcaa cctggagagg gagtgcatgg       60

aggagaagtg cagctttgag gaggccaggg aggtgtttga gaacacagag aggaccacag      120

agttctggaa gcagtatgtg gatggtgacc agtgtgagag caacccttgc ctgaatggag      180

gcagctgcaa ggatgacatc aacagctatg agtgctggtg cccttttggc tttgagggca      240

agaactgtga gctggatgtg acctgcaaca tcaagaatgg caggtgtgag cagttctgca      300

agaactctgc tgacaacaag gtggtgtgta gctgcacaga gggctacaga ctggctgaga      360

accagaagag ctgtgagcct gctgtgccct tcccctgtgg cagagtgtct gtgtcccaga      420

ccagcaagct gaccagagct gagacagtgt tccctgatgt ggactatgtg aacagcacag      480

aggctgagac catcctggac aacatcaccc agagcaccca gtccttcaat gacttcacca      540

gagtggtggg aggagaggat gccaagcctg gccagttccc ctggcaggtg gtgctgaatg      600

gcaaggtgga tgccttctgt ggaggcagca ttgtgaatga gaagtggatt gtgacagctg      660

cccactgtgt ggagacagga gtgaagatca cagtggtggc tggagagcac aacattgagg      720

agacagagca cacagagcag aagaggaatg tgatcaggat catccctcac cacaactaca      780

atgctgccat caacaagtac aaccatgaca ttgccctgct ggagctggat gagcctctgg      840

tgctgaacag ctatgtgacc cctatctgca ttgctgacaa ggagtacacc aacatcttcc      900

tgaagtttgg ctctggctat gtgtctggct ggggcagagt gttccacaag ggcaggtctg      960

ccctggtgct gcagtacctg agagtgcccc tggtggacag agccacctgc ctgttgagca     1020

ccaagttcac catctacaac aacatgttct gtgctggctt ccatgaggga ggcagagaca     1080

gctgccaggg tgactctgga ggaccccatg tgacagaggt ggagggcacc agcttcctga     1140

caggcatcat cagctgggga gaggagtgtg ccatgaaggg caagtatggc atctacacca     1200

aagtgagcag atatgtgaac tggatcaagg agaagaccaa gctgacctga                1250


<210>  16
<211>  1248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS05-MP-NA

<400>  16
tacaactctg gcaagctgga ggagtttgtg cagggcaacc tggagaggga gtgcatggag       60

gagaagtgca gctttgagga ggccagggag gtgtttgaga acactgagcg caccactgag      120

ttctggaagc agtatgtgga tggggaccag tgtgagagca acccctgcct gaatgggggg      180

agctgcaagg atgacatcaa cagctatgag tgctggtgcc cctttggctt tgagggcaag      240

aactgtgagc tggatgtgac ctgcaacatc aagaatggcc gctgtgagca gttctgcaag      300

aactctgctg acaacaaggt ggtgtgctct tgcactgagg gctaccgcct ggctgagaac      360

cagaagagct gtgagcctgc tgtgcccttc ccctgtggca gggtgtctgt gagccagacc      420

agcaagctga ccagggctga gactgtgttc cctgacgtgg actatgtgaa cagcactgag      480

gctgagacca tcctggacaa catcacccag agcacccaga gcttcaatga cttcaccagg      540

gtggtgggag gagaggatgc caagcctggc cagttcccct ggcaggtggt gctgaatggc      600

aaggtggatg ccttctgtgg aggcagcatt gtgaatgaga agtggattgt gaccgctgcc      660

cactgtgtgg agactggagt gaagatcact gtggtggctg gggagcacaa cattgaggag      720

acagagcaca cagagcagaa gcgcaatgtg atcaggatca tcccccacca caactacaat      780

gctgccatca acaagtacaa ccatgacatt gccctgctgg agctggatga gcccctggtg      840

ctgaacagct acgtgacccc catctgcatt gcagacaagg agtacaccaa catcttcctg      900

aagtttggct ctggctatgt gtctggctgg ggcagggtgt tccacaaggg caggtctgcc      960

ctggtgctgc agtacctgag ggtgcccctg gtggacaggg ccacctgcct gctgagcacc     1020

aagttcacca tctacaacaa catgttctgc gctggcttcc atgagggagg aagggacagc     1080

tgccagggag actctggagg cccccatgtg acagaggtgg agggcaccag cttcctgaca     1140

ggcatcatca gctgggggga ggagtgtgcc atgaagggca agtatggcat ctacaccaaa     1200

gtgtcccgct atgtgaactg gatcaaggag aagaccaagc tgacctga                  1248


<210>  17
<211>  1248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS06-MP-NA

<400>  17
tacaactctg gcaaactgga ggagtttgtc cagggcaacc tggagaggga gtgcatggag       60

gagaagtgct cctttgagga ggccagggag gtctttgaga acactgagcg caccactgag      120

ttctggaaac agtatgtgga tggggaccag tgtgagtcca acccctgcct gaatgggggc      180

agctgcaagg atgacatcaa cagctatgag tgctggtgcc cctttggctt tgagggcaag      240

aactgtgagc tggatgtgac ctgcaacatc aagaatggca gatgtgagca gttctgcaag      300

aactctgctg acaacaaggt ggtgtgctcc tgcactgagg gctaccgcct ggctgagaac      360

cagaagagct gtgagcctgc tgtgccattc ccatgtggca gagtctctgt gagccagacc      420

agcaagctca ccagggctga gactgtgttc cctgatgtgg actatgtgaa cagcactgag      480

gctgaaacca tcctggacaa catcacccag agcacccaga gcttcaatga cttcaccaga      540

gtggtgggag gagaggatgc caagcctggc cagttcccct ggcaagtggt gctcaatggc      600

aaggtggatg ccttctgtgg gggctccatt gtgaatgaga agtggattgt cactgctgcc      660

cactgtgtgg agactggggt caagatcact gtggtggctg gggagcacaa cattgaggag      720

actgagcaca ctgagcagaa gcgcaatgtg atcaggatca tcccccacca caactacaat      780

gctgccatca acaagtacaa ccatgacatt gccctgctgg agctggatga gcccctggtc      840

ctcaacagct atgtgacccc catctgcatt gctgacaagg agtacaccaa catcttcctc      900

aagtttggct ctggctatgt ctctggctgg ggcagagtgt tccacaaagg caggtctgcc      960

ctggtgctcc agtacctgag agtgcccctg gtggacaggg ccacctgcct cttgagcacc     1020

aagttcacca tctacaacaa catgttctgt gctggcttcc atgagggagg aagagacagc     1080

tgccaggggg actctggagg accccatgtc actgaggtgg agggcacctc cttcctcact     1140

ggcatcatct cctggggaga ggagtgtgcc atgaaaggca aatatggcat ctacaccaaa     1200

gtctccagat atgtcaactg gatcaaggag aagaccaagc tgacctga                  1248


<210>  18
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FIX-PPP-NA

<400>  18
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta       60

ggatatctac tcagtgctga atgtacagtt tttcttgatc atgaaaacgc caacaaaatt      120

ctgaatcggc caaagagg                                                    138


<210>  19
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS02-PPP-NA

<400>  19
atgcagaggg tgaacatgat catggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtcagcaga gtgcacagtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagaga                                                    138


<210>  20
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS03-PPP-NA

<400>  20
atgcagaggg tgaacatgat catggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcactgtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagaga                                                    138


<210>  21
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS04-PPP-NA

<400>  21
atgcagaggg tgaacatgat tatggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcacagtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagaga                                                    138


<210>  22
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS05-PPP-NA

<400>  22
atgcagaggg tgaacatgat tatggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcactgtg ttcctggacc atgagaatgc caacaagatc      120

ctgaaccgcc ccaagcgc                                                    138


<210>  23
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS06-PPP-NA

<400>  23
atgcagaggg tcaacatgat catggctgag tcccctggcc tcatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcactgtc ttcctggacc atgagaatgc caacaagatc      120

ctcaacaggc ccaagaga                                                    138


<210>  24
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FIX-SP-NA

<400>  24
atgcagcgcg tgaacatgat catggcagaa tcaccaggcc tcatcaccat ctgcctttta       60

ggatatctac tcagtgctga atgt                                              84


<210>  25
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS02-SP-NA

<400>  25
atgcagaggg tgaacatgat catggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtcagcaga gtgc                                              84


<210>  26
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS03-SP-NA

<400>  26
atgcagaggg tgaacatgat catggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgc                                              84


<210>  27
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS04-SP-NA

<400>  27
atgcagaggg tgaacatgat tatggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgc                                              84


<210>  28
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS05-SP-NA

<400>  28
atgcagaggg tgaacatgat tatggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgc                                              84


<210>  29
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS06--SP-NA

<400>  29
atgcagaggg tcaacatgat catggctgag tcccctggcc tcatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgc                                              84


<210>  30
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FIX-PP-NA

<400>  30
acagtttttc ttgatcatga aaacgccaac aaaattctga atcggccaaa gagg             54


<210>  31
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS02-PP-NA

<400>  31
acagtgttcc tggaccatga gaatgccaac aagatcctga acaggcccaa gaga             54


<210>  32
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS03-PP-NA

<400>  32
actgtgttcc tggaccatga gaatgccaac aagatcctga acaggcccaa gaga             54


<210>  33
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS04-PP-NA

<400>  33
acagtgttcc tggaccatga gaatgccaac aagatcctga acaggcccaa gaga             54


<210>  34
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS05-PP-NA

<400>  34
actgtgttcc tggaccatga gaatgccaac aagatcctga accgccccaa gcgc             54


<210>  35
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS06-PP-NA

<400>  35
actgtcttcc tggaccatga gaatgccaac aagatcctca acaggcccaa gaga             54


<210>  36
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX-PPP-AA

<400>  36

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg 
        35                  40                  45      


<210>  37
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX-SP-AA

<400>  37

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys 
            20                  25              


<210>  38
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX-PP-AA

<400>  38

Thr Val Phe Leu Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro 
1               5                   10                  15      


Lys Arg 
        


<210>  39
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRM8

<400>  39
gggggaggct gctggtgaat attaaccaag gtcaccccag ttatcggagg agcaaacagg       60

ggctaagtcc ac                                                           72


<210>  40
<211>  5276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS06-CRM8.3-ssV

<400>  40
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctgagtt taaacttcgt cgacggggga ggctgctggt      180

gaatattaac caaggtcacc ccagttatcg gaggagcaaa caggggctaa gtccaccggg      240

ggaggctgct ggtgaatatt aaccaaggtc accccagtta tcggaggagc aaacaggggc      300

taagtccacc gggggaggct gctggtgaat attaaccaag gtcaccccag ttatcggagg      360

agcaaacagg ggctaagtcc accgagggca ctgggaggat gttgagtaag atggaaaact      420

actgatgacc cttgcagaga cagagtatta ggacatgttt gaacaggggc cgggcgatca      480

gcaggtagct ctagaggatc cccgtctgtc tgcacatttc gtagagcgag tgttccgata      540

ctctaatctc cctaggcaag gttcatattt gtgtaggtta cttattctcc ttttgttgac      600

taagtcaata atcagaatca gcaggtttgg agtcagcttg gcagggatca gcagcctggg      660

ttggaaggag ggggtataaa agccccttca ccaggagaag ccgtcacaca gactaggcgc      720

gccctaaggt aagttggcgc cgtttaaggg atggttggtt ggtggggtat taatgtttaa      780

ttaccttttt tacaggcctg aagatctgcc accatgcaga gggtcaacat gatcatggct      840

gagtcccctg gcctcatcac catctgcctg ctgggctacc tgctgtctgc tgagtgcact      900

gtcttcctgg accatgagaa tgccaacaag atcctcaaca ggcccaagag atacaactct      960

ggcaaactgg aggagtttgt ccagggcaac ctggagaggg agtgcatgga ggagaagtgc     1020

tcctttgagg aggccaggga ggtctttgag aacactgagc gcaccactga gttctggaaa     1080

cagtatgtgg atggggacca gtgtgagtcc aacccctgcc tgaatggggg cagctgcaag     1140

gatgacatca acagctatga gtgctggtgc ccctttggct ttgagggcaa gaactgtgag     1200

ctggatgtga cctgcaacat caagaatggc agatgtgagc agttctgcaa gaactctgct     1260

gacaacaagg tggtgtgctc ctgcactgag ggctaccgcc tggctgagaa ccagaagagc     1320

tgtgagcctg ctgtgccatt cccatgtggc agagtctctg tgagccagac cagcaagctc     1380

accagggctg agactgtgtt ccctgatgtg gactatgtga acagcactga ggctgaaacc     1440

atcctggaca acatcaccca gagcacccag agcttcaatg acttcaccag agtggtggga     1500

ggagaggatg ccaagcctgg ccagttcccc tggcaagtgg tgctcaatgg caaggtggat     1560

gccttctgtg ggggctccat tgtgaatgag aagtggattg tcactgctgc ccactgtgtg     1620

gagactgggg tcaagatcac tgtggtggct ggggagcaca acattgagga gactgagcac     1680

actgagcaga agcgcaatgt gatcaggatc atcccccacc acaactacaa tgctgccatc     1740

aacaagtaca accatgacat tgccctgctg gagctggatg agcccctggt cctcaacagc     1800

tatgtgaccc ccatctgcat tgctgacaag gagtacacca acatcttcct caagtttggc     1860

tctggctatg tctctggctg gggcagagtg ttccacaaag gcaggtctgc cctggtgctc     1920

cagtacctga gagtgcccct ggtggacagg gccacctgcc tcttgagcac caagttcacc     1980

atctacaaca acatgttctg tgctggcttc catgagggag gaagagacag ctgccagggg     2040

gactctggag gaccccatgt cactgaggtg gagggcacct ccttcctcac tggcatcatc     2100

tcctggggag aggagtgtgc catgaaaggc aaatatggca tctacaccaa agtctccaga     2160

tatgtcaact ggatcaagga gaagaccaag ctgacctgat gagcatgcct agagctcgct     2220

gatcagcctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc     2280

cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg     2340

catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca     2400

agggggagga ttgggaagac aatagcaggc atgctgggga attaattaag ctcgcgaagg     2460

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     2520

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag     2580

cgcgcagaga gggagtggcc aagacgattt aaatgacaag cttggcgtaa tcatggtcat     2640

agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata cgagccggaa     2700

gcataaagtg taaagcctgg ggtgcctaat gagtgagcta actcacatta attgcgttgc     2760

gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc     2820

aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact     2880

cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag gcggtaatac     2940

ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa     3000

aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc cgcccccctg     3060

acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca ggactataaa     3120

gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg accctgccgc     3180

ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct catagctcac     3240

gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac     3300

cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag tccaacccgg     3360

taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc agagcgaggt     3420

atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac actagaagaa     3480

cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga gttggtagct     3540

cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc aagcagcaga     3600

ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg     3660

ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct     3720

tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt     3780

aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc     3840

tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg     3900

gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca ccggctccag     3960

atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt     4020

tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag     4080

ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt     4140

ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca tgatccccca     4200

tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga agtaagttgg     4260

ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact gtcatgccat     4320

ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga gaatagtgta     4380

tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg ccacatagca     4440

gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc tcaaggatct     4500

taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga tcttcagcat     4560

cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa     4620

agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt caatattatt     4680

gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa     4740

ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac gtctaagaaa     4800

ccattattat catgacatta acctataaaa ataggcgtat cacgaggccc tttcgtctcg     4860

cgcgtttcgg tgatgacggt gaaaacctct gacacatgca gctcccggag acggtcacag     4920

cttgtctgta agcggatgcc gggagcagac aagcccgtca gggcgcgtca gcgggtgttg     4980

gcgggtgtcg gggctggctt aactatgcgg catcagagca gattgtactg agagtgcacc     5040

atatgcggtg tgaaataccg cacagatgcg taaggagaaa ataccgcatc aggcgccatt     5100

cgccattcag gctgcgcaac tgttgggaag ggcgatcggt gcgggcctct tcgctattac     5160

gccagctggc gaaaggggga tgtgctgcaa ggcgattaag ttgggtaacg ccagggtttt     5220

cccagtcacg acgttgtaaa acgacggcca gtgaattcct cgagatttaa atgacg         5276


<210>  41
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS02-HC-NA

<400>  41
gttgtgggag gagaggatgc caagcctggc cagttcccct ggcaggtggt gctgaatggc       60

aaagtggatg ccttctgtgg aggcagcatt gtgaatgaga agtggattgt gacagctgcc      120

cactgtgtgg agacaggagt gaagatcaca gtggtggctg gagaacacaa tattgaggag      180

acagagcaca cagagcagaa gaggaatgtc atcaggatta tcccccacca caactacaat      240

gctgccatca acaagtacaa ccatgacatt gccctgctgg agctggatga gcctctggtg      300

ctgaatagct atgtgacccc catctgcatt gctgacaagg agtacaccaa catcttcctg      360

aagtttggct caggctatgt gtcaggctgg ggcagagtgt tccacaaggg cagatcagcc      420

ctggtgctgc agtacctgag agtgcccctg gtggacagag ccacctgcct gttgagcacc      480

aagttcacca tctacaacaa catgttctgt gctggcttcc atgagggagg cagagacagc      540

tgccagggag actcaggagg accccatgtg acagaagtgg agggcaccag cttcctgaca      600

ggcatcatca gctggggaga ggagtgtgcc atgaagggca agtatggcat ctacaccaaa      660

gtgagcagat atgtgaactg gatcaaggag aaaaccaagc tg                         702


<210>  42
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS02-LC-NA

<400>  42
tacaactcag gcaagctgga ggagtttgtg cagggcaacc tggagaggga gtgcatggag       60

gagaagtgca gctttgagga ggccagagag gtgtttgaga acacagagag gaccacagag      120

ttctggaagc agtatgtgga tggagaccag tgtgagagca acccttgcct gaatggaggc      180

agctgcaagg atgacatcaa cagctatgag tgctggtgcc cttttggctt tgagggcaag      240

aactgtgagc tggatgtgac ctgcaacatc aagaatggca ggtgtgagca gttctgcaag      300

aactcagctg acaacaaagt ggtgtgtagc tgcacagagg gctacagact ggctgagaac      360

cagaagagct gtgagcctgc tgtgcccttc ccctgtggca gagtgtcagt gtcccagacc      420

agcaagctga ccaga                                                       435


<210>  43
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS03-HC-NA

<400>  43
gtggtggggg gggaggatgc caagcctggc cagttcccct ggcaggtggt gctgaatggc       60

aaagtggatg ccttctgtgg gggcagcatt gtgaatgaga agtggattgt gactgctgcc      120

cactgtgtgg agactggggt gaagatcact gtggtggctg gggaacacaa tattgaggag      180

actgagcaca ctgagcagaa gaggaatgtc atcaggatta tcccccacca caactacaat      240

gctgccatca acaagtacaa ccatgacatt gccctgctgg agctggatga gcctctggtg      300

ctgaatagct atgtgacccc catctgcatt gctgacaagg agtacaccaa catcttcctg      360

aagtttggct ctggctatgt gtctggctgg ggcagagtgt tccacaaggg caggtctgcc      420

ctggtgctgc agtacctgag agtgcccctg gtggacagag ccacctgcct gctgagcacc      480

aagttcacca tctacaacaa catgttctgt gctggcttcc atgagggggg cagagacagc      540

tgccaggggg actctggggg cccccatgtg actgaagtgg agggcaccag cttcctgact      600

ggcatcatca gctgggggga ggagtgtgcc atgaagggca agtatggcat ctacaccaaa      660

gtgagcaggt atgtgaactg gatcaaggag aaaaccaagc tgacc                      705


<210>  44
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS03-LC-NA

<400>  44
tacaactctg gcaagctgga ggagtttgtg cagggcaacc tggagaggga gtgcatggag       60

gagaagtgca gctttgagga ggccagggaa gtgtttgaga acactgagag gaccactgag      120

ttctggaagc agtatgtgga tggggaccag tgtgagagca acccttgcct gaatgggggc      180

agctgcaagg atgacatcaa cagctatgag tgctggtgcc cttttggctt tgagggcaag      240

aactgtgagc tggatgtgac ctgcaacatc aagaatggca ggtgtgagca gttctgcaag      300

aactctgctg acaacaaagt ggtgtgtagc tgcactgagg gctacagact ggctgagaac      360

cagaagagct gtgagcctgc tgtgcccttc ccctgtggca gagtgtctgt gtcccagacc      420

agcaagctga ccaga                                                       435


<210>  45
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS04-HC-NA

<400>  45
gtggtgggag gagaggatgc caagcctggc cagttcccct ggcaggtggt gctgaatggc       60

aaggtggatg ccttctgtgg aggcagcatt gtgaatgaga agtggattgt gacagctgcc      120

cactgtgtgg agacaggagt gaagatcaca gtggtggctg gagagcacaa cattgaggag      180

acagagcaca cagagcagaa gaggaatgtg atcaggatca tccctcacca caactacaat      240

gctgccatca acaagtacaa ccatgacatt gccctgctgg agctggatga gcctctggtg      300

ctgaacagct atgtgacccc tatctgcatt gctgacaagg agtacaccaa catcttcctg      360

aagtttggct ctggctatgt gtctggctgg ggcagagtgt tccacaaggg caggtctgcc      420

ctggtgctgc agtacctgag agtgcccctg gtggacagag ccacctgcct gttgagcacc      480

aagttcacca tctacaacaa catgttctgt gctggcttcc atgagggagg cagagacagc      540

tgccagggtg actctggagg accccatgtg acagaggtgg agggcaccag cttcctgaca      600

ggcatcatca gctggggaga ggagtgtgcc atgaagggca agtatggcat ctacaccaaa      660

gtgagcagat atgtgaactg gatcaaggag aagaccaagc tgacc                      705


<210>  46
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS04-LC-NA

<400>  46
tacaactctg gcaagctgga ggagtttgtg cagggcaacc tggagaggga gtgcatggag       60

gagaagtgca gctttgagga ggccagggag gtgtttgaga acacagagag gaccacagag      120

ttctggaagc agtatgtgga tggtgaccag tgtgagagca acccttgcct gaatggaggc      180

agctgcaagg atgacatcaa cagctatgag tgctggtgcc cttttggctt tgagggcaag      240

aactgtgagc tggatgtgac ctgcaacatc aagaatggca ggtgtgagca gttctgcaag      300

aactctgctg acaacaaggt ggtgtgtagc tgcacagagg gctacagact ggctgagaac      360

cagaagagct gtgagcctgc tgtgcccttc ccctgtggca gagtgtctgt gtcccagacc      420

agcaagctga ccaga                                                       435


<210>  47
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS05-HC-NA

<400>  47
gtggtgggag gagaggatgc caagcctggc cagttcccct ggcaggtggt gctgaatggc       60

aaggtggatg ccttctgtgg aggcagcatt gtgaatgaga agtggattgt gaccgctgcc      120

cactgtgtgg agactggagt gaagatcact gtggtggctg gggagcacaa cattgaggag      180

acagagcaca cagagcagaa gcgcaatgtg atcaggatca tcccccacca caactacaat      240

gctgccatca acaagtacaa ccatgacatt gccctgctgg agctggatga gcccctggtg      300

ctgaacagct acgtgacccc catctgcatt gcagacaagg agtacaccaa catcttcctg      360

aagtttggct ctggctatgt gtctggctgg ggcagggtgt tccacaaggg caggtctgcc      420

ctggtgctgc agtacctgag ggtgcccctg gtggacaggg ccacctgcct gctgagcacc      480

aagttcacca tctacaacaa catgttctgc gctggcttcc atgagggagg aagggacagc      540

tgccagggag actctggagg cccccatgtg acagaggtgg agggcaccag cttcctgaca      600

ggcatcatca gctgggggga ggagtgtgcc atgaagggca agtatggcat ctacaccaaa      660

gtgtcccgct atgtgaactg gatcaaggag aagaccaagc tgacc                      705


<210>  48
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS05-LC-NA

<400>  48
tacaactctg gcaagctgga ggagtttgtg cagggcaacc tggagaggga gtgcatggag       60

gagaagtgca gctttgagga ggccagggag gtgtttgaga acactgagcg caccactgag      120

ttctggaagc agtatgtgga tggggaccag tgtgagagca acccctgcct gaatgggggg      180

agctgcaagg atgacatcaa cagctatgag tgctggtgcc cctttggctt tgagggcaag      240

aactgtgagc tggatgtgac ctgcaacatc aagaatggcc gctgtgagca gttctgcaag      300

aactctgctg acaacaaggt ggtgtgctct tgcactgagg gctaccgcct ggctgagaac      360

cagaagagct gtgagcctgc tgtgcccttc ccctgtggca gggtgtctgt gagccagacc      420

agcaagctga ccagg                                                       435


<210>  49
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS06-HC-NA

<400>  49
gtggtgggag gagaggatgc caagcctggc cagttcccct ggcaagtggt gctcaatggc       60

aaggtggatg ccttctgtgg gggctccatt gtgaatgaga agtggattgt cactgctgcc      120

cactgtgtgg agactggggt caagatcact gtggtggctg gggagcacaa cattgaggag      180

actgagcaca ctgagcagaa gcgcaatgtg atcaggatca tcccccacca caactacaat      240

gctgccatca acaagtacaa ccatgacatt gccctgctgg agctggatga gcccctggtc      300

ctcaacagct atgtgacccc catctgcatt gctgacaagg agtacaccaa catcttcctc      360

aagtttggct ctggctatgt ctctggctgg ggcagagtgt tccacaaagg caggtctgcc      420

ctggtgctcc agtacctgag agtgcccctg gtggacaggg ccacctgcct cttgagcacc      480

aagttcacca tctacaacaa catgttctgt gctggcttcc atgagggagg aagagacagc      540

tgccaggggg actctggagg accccatgtc actgaggtgg agggcacctc cttcctcact      600

ggcatcatct cctggggaga ggagtgtgcc atgaaaggca aatatggcat ctacaccaaa      660

gtctccagat atgtcaactg gatcaaggag aagaccaagc tgacc                      705


<210>  50
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS06-LC-NA

<400>  50
tacaactctg gcaaactgga ggagtttgtc cagggcaacc tggagaggga gtgcatggag       60

gagaagtgct cctttgagga ggccagggag gtctttgaga acactgagcg caccactgag      120

ttctggaaac agtatgtgga tggggaccag tgtgagtcca acccctgcct gaatgggggc      180

agctgcaagg atgacatcaa cagctatgag tgctggtgcc cctttggctt tgagggcaag      240

aactgtgagc tggatgtgac ctgcaacatc aagaatggca gatgtgagca gttctgcaag      300

aactctgctg acaacaaggt ggtgtgctcc tgcactgagg gctaccgcct ggctgagaac      360

cagaagagct gtgagcctgc tgtgccattc ccatgtggca gagtctctgt gagccagacc      420

agcaagctca ccagg                                                       435


<210>  51
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2_5'-ITR

<400>  51
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcct                                            145


<210>  52
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  truncated_TTR_enhancer/promoter

<400>  52
cgagggcact gggaggatgt tgagtaagat ggaaaactac tgatgaccct tgcagagaca       60

gagtattagg acatgtttga acaggggccg ggcgatcagc aggtagctct agaggatccc      120

cgtctgtctg cacatttcgt agagcgagtg ttccgatact ctaatctccc taggcaaggt      180

tcatatttgt gtaggttact tattctcctt ttgttgacta agtcaataat cagaatcagc      240

aggtttggag tcagcttggc agggatcagc agcctgggtt ggaaggaggg ggtataaaag      300

ccccttcacc aggagaagcc gtcacacaga                                       330


<210>  53
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MVM_intron

<400>  53
ctaaggtaag ttggcgccgt ttaagggatg gttggttggt ggggtattaa tgtttaatta       60

ccttttttac aggcctg                                                      77


<210>  54
<211>  234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGH_poly-adenylation_signal

<400>  54
cctagagctc gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc       60

ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa      120

aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg      180

gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggaa            234


<210>  55
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 3'-ITR

<400>  55
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  56
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX-AP-AA

<400>  56

Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala 
1               5                   10                  15      


Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp 
            20                  25                  30          


Phe Thr Arg 
        35  


<210>  57
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS02-AP-NA

<400>  57
gctgagacag tgttccctga tgtggactat gtgaatagca cagaggctga gaccatcctg       60

gacaacatca cccagagcac ccagtccttc aatgacttca ccaga                      105


<210>  58
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS03-AP-NA

<400>  58
gctgagactg tgttccctga tgtggactat gtgaatagca ctgaggctga gaccatcctg       60

gacaacatca cccagagcac ccagtccttc aatgacttca ccaga                      105


<210>  59
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS04-AP-NA

<400>  59
gctgagacag tgttccctga tgtggactat gtgaacagca cagaggctga gaccatcctg       60

gacaacatca cccagagcac ccagtccttc aatgacttca ccaga                      105


<210>  60
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS05-AP-NA

<400>  60
gctgagactg tgttccctga cgtggactat gtgaacagca ctgaggctga gaccatcctg       60

gacaacatca cccagagcac ccagagcttc aatgacttca ccagg                      105


<210>  61
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CS06-AP-NA

<400>  61
gctgagactg tgttccctga tgtggactat gtgaacagca ctgaggctga aaccatcctg       60

gacaacatca cccagagcac ccagagcttc aatgacttca ccaga                      105


<210>  62
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX-LC-AA

<400>  62

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg 
145 


<210>  63
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIX-HC-AA

<400>  63

Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp Gln Val 
1               5                   10                  15      


Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile Val Asn 
            20                  25                  30          


Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly Val Lys 
        35                  40                  45              


Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu His Thr 
    50                  55                  60                  


Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn Tyr Asn 
65                  70                  75                  80  


Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu Leu Asp 
                85                  90                  95      


Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile Ala Asp 
            100                 105                 110         


Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr Val Ser 
        115                 120                 125             


Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val Leu Gln 
    130                 135                 140                 


Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg Ser Thr 
145                 150                 155                 160 


Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His Glu Gly 
                165                 170                 175     


Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Glu 
            180                 185                 190         


Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly Glu Glu 
        195                 200                 205             


Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser Arg Tyr 
    210                 215                 220                 


Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
225                 230                 235 


<210>  64
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FIXp-HC-AA

<400>  64

Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp Gln Val 
1               5                   10                  15      


Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile Val Asn 
            20                  25                  30          


Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly Val Lys 
        35                  40                  45              


Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu His Thr 
    50                  55                  60                  


Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn Tyr Asn 
65                  70                  75                  80  


Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu Leu Asp 
                85                  90                  95      


Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile Ala Asp 
            100                 105                 110         


Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr Val Ser 
        115                 120                 125             


Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Leu Val Leu Gln 
    130                 135                 140                 


Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Leu Ser Thr 
145                 150                 155                 160 


Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His Glu Gly 
                165                 170                 175     


Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val Thr Glu 
            180                 185                 190         


Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly Glu Glu 
        195                 200                 205             


Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser Arg Tyr 
    210                 215                 220                 


Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
225                 230                 235 


