
                                SEQUENCE LISTING

<110> Courtney Crane
      Jennifer Gardell
      Harrison Kikuo Chinn

<120> MICROENVIRONMENT SENSORS TO REGULATE
  ENGINEERED GENE EXPRESSION
  

<130> SCRI.207WO

<150> 62800049            
<151> 2019-02-01  

<160> 54

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 996
<212> DNA
<213> Artificial Sequence

<220> 
<223> APOE Promoter: GH19J044900

<400> 1
gaggtgctgg aatctcattt cacatgtggg gagggggctc ccctgtgctc aaggtcacaa 60
ccaaagagga agctgtgatt aaaacccagg tcccatttgc aaagcctcga cttttagcag 120
gtgcatcata ctgttcccac ccctcccatc ccacttctgt ccagccgcct agccccactt 180
tctttttttt ctttttttga gacagtctcc ctcttgctga ggctggagtg cagtggcgag 240
atctcggctc actgtaacct ccgcctcccg ggttcaagcg attctcctgc ctcagcctcc 300
caagtagcta ggattacagg cgcccgccac cacgcctggc taacttttgt atttttagta 360
gagatggggt ttcaccatgt tggccaggct ggtctcaaac tcctgacctt aagtgattcg 420
cccactgtgg cctcccaaag tgctgggatt acaggcgtga gctaccgccc ccagcccctc 480
ccatcccact tctgtccagc cccctagccc tactttcttt ctgggatcca ggagtccaga 540
tccccagccc cctctccaga ttacattcat ccaggcacag gaaaggacag ggtcaggaaa 600
ggaggactct gggcggcagc ctccacattc cccttccacg cttggccccc agaatggagg 660
agggtgtctg tattactggg cgaggtgtcc tcccttcctg gggactgtgg ggggtggtca 720
aaagacctct atgccccacc tccttcctcc ctctgccctg ctgtgcctgg ggcaggggga 780
gaacagccca cctcgtgact gggggctggc ccagcccgcc ctatccctgg gggagggggc 840
gggacagggg gagccctata attggacaag tctgggatcc ttgagtccta ctcagcccca 900
gcggaggtga aggacgtcct tccccaggag ccggtgagaa gcgcagtcgg gggcacgggg 960
atgagctcag gggcctctag aaagagctgg gaccct                           996

<210> 2
<211> 800
<212> DNA
<213> Artificial Sequence

<220> 
<223> C1QA Promoter: GH01J022636

<400> 2
gtgagccaaa gcacctagac ttgctgtttt tttaaatgtt ggcaaaagct agtgactaag 60
tgttcaccat gtgccaagtg ttttgtatgt gcaagtcatt aaaatgttat aataatcaga 120
tgatatagga ccccgttccc agtgtacaga taaaactgag ggctcaggag gtcaagtaat 180
ttcccaaaga catgcaacta ggaagcagca agtctagaaa cagattgctg tgcttccttc 240
tcaccaatgc actgttcttt cttctttgta ttttccaagc ttttggcaat gaattgcatg 300
tcactttcat aatcatgaaa agtcctacaa gggacagatt tttttaaaga ttccttccgc 360
tctggtgttc tgtgcttcgc tggttctcag aacctcaccc tgcacggcct ccaccccaca 420
tcctcacagg cactggcctc actgccccca ctcccacacc agctgttgct ggggcaggac 480
gcccaatgtc ccagtcttgc tgaagtctgc ttgaaatgtc cctggtgagc ttctggccac 540
tggggaagtt cagggggcag gtctgaagaa ggggaagtag gaagggatgt gaaacttggc 600
cacagcctgg agccactcct gctgggcagc ccacagggtc cctgggcgga gggcaggagc 660
atccagttgg agttgacaac aggaggcagg tgaggccaga gtcccagagg gagggggctg 720
cagagttctg ggacccaggg gagctggccc aggaggctgg gcagctgagg cagggaggga 780
gggaaataac tgtgcctgat                                             800

<210> 3
<211> 1060
<212> DNA
<213> Artificial Sequence

<220> 
<223> SPP1 Promoter: GH04J087974

<400> 3
caaagctaag attttgcctt taggaaagtt ttctttccta ataaaatagt ttatttgaca 60
actattcttt ttattaggat cattcatata tttgctaagc aaagagtaaa tttattttcc 120
ttaagattca atttgaatat actaagaata ttaaagcaag ttagataaat tacccaatat 180
atttgtcaat ttgaaatttg atagacatta gttgtttaat tcaatgggca gttttgagct 240
gcagtttata cacacatgca taacagagtc acctttcaat tatccatgtt aataggaaag 300
tggttataga ttttagtaca cacattaaaa tatggatact cttctctttt gataaatctc 360
atttcaaata aaaaaaccag tctcataatt atgtatctgt atctattaca tcattgaatt 420
tagtaaataa tgtttaatat gtataaggaa aaacaatgtt attgacatga agattatact 480
cacatatttg gcttgaaaat atctataaaa ataatttctg ttgcaaagta agaaatgttc 540
ttcagaatgt tattaatccc tgtgttaaaa gagaaattgg aagatgctca ctttagctcc 600
taaaagccat ggtatgtact gtgaatgcaa agattctgaa actaaataaa aagaaagata 660
gtaaaagact aatgtgctat aaaggctaag ggaaaataaa aacccatata ttaattttcc 720
cggccatctt aattttcaga cccttccaag taagtccaac gaaagccatg accacatgga 780
tgatatggat gatgaagatg atgatgacca tgtggacagc caggactcca ttgactcgaa 840
cgactctgat gatgtagatg acactgatga ttctcaccag tctgatgagt ctcaccattc 900
tgatgaatct gatgaactgg tcactgattt tcccacggac ctgccagcaa ccgaagtttt 960
cactccagtt gtccccacag tagacacata tgatggccga ggtgatagtg tggtttatgg 1020
actgaggtca aaatctaaga agtttcgcag acctgacatc                       1060

<210> 4
<211> 958
<212> DNA
<213> Artificial Sequence

<220> 
<223> RGS1 promoter: GH01J192575

<400> 4
accttgagca gtttttcctc tgatactgtg accttggtat cagtatgttt acaaattatg 60
tcatatttgt atacaattaa acatttattt atttatgatt ggttttaatt aaactttatt 120
ttttcctaat atgcaaaata tgcaaaaatc aaagtttgat atactagtta tattcttaat 180
aaatatgaaa ataatattaa aaaccatgca ccccttaaaa tcatcctatg tattgccagt 240
cgatgtctag cacacacctt ggaaaatatt aacatggaaa tttcctgcca tggaaataag 300
ggatgagaat tggagtggga aaatgtgaag atagcctctt ataactttcc ctcctatcag 360
atatgtgcaa aataattaaa caaaaattat ttgtttactt tgccctgctt cctgcagaaa 420
agaagagaac tcttaaaata ttttgatcag atgaatttta tagtcaagga ctatccaaag 480
catggagtaa gatacaactc tatgtgatga atttctatgt gagtttctat atgataaatt 540
aatacgccaa atgaaacagt ttattgaaac atgcaacttt tttaaaataa acaaacatcc 600
tccagaacca aagactgatg ctgttaatgc tttagacatg tgacatatgt gtgtgtacct 660
ctgtatgttt aattttcttt ctttctaatc aagtgacctg ttctcgtttg gttaagtttc 720
aaccacaaga caccactgta tgcttttttt ttttcaagat acacgtcaca gcacaccaag 780
aaaaggggaa cttccagtgt ctgtggtaac atcacttgat aaacagactc ctttaaacag 840
caagtgcctg tctgcattct actatataaa gcagcagaga cgttgactag cgcatatttg 900
ctaagagcac catgcgcgca gcagccatct ccactccaaa gttagacaaa atgccagg   958

<210> 5
<211> 1091
<212> DNA
<213> Artificial Sequence

<220> 
<223> C3 Promoter

<400> 5
ggaggaagac cacctttact gctatacaca tttgtacctt ttagatgttg atcaatatga 60
atatattata cacacagaca cacacacaga cacacacaca cacacaaaca atacaattta 120
atatcctaag aggatattga cattagacag gtacaaaagc tctagaaatg aggactttcc 180
tcagtgatga cttttttcac caccaaagtc actcaggcat cctgacaagg gtaagtgagg 240
ggagcctcct tggaaaataa actcacttgg atagtgaact cctgcacata cctcaaagcc 300
catctgaaat gtcccctcct acaggaagtt ttccctgacc ctccaagaag cagagttcta 360
tttcactggg gaaaacattt cttcttcttc ttttttttcc ctgccctgca catgagctag 420
aaaacatttc atgaaactgg gagtttctgt gctgggctct gtccctcccc cattctactt 480
cccctccctc agcatggaag cctctggaag tggggctctg actcccagcc tacagagaga 540
ttcctaggaa gtgttcgact gataaacgca tggccaaaag tgaactgggg atgaggtcca 600
agacatctgc ggtggggggt tctccagacc ttagtgttct tccactacaa agtgggtcca 660
acagagaaag gtctgtgttc accaggtggc cctgaccctg ggagagtcca gggcagggtg 720
cagctgcatt catgctgctg gggaacatgc cctcaggtta ctcaccccat ggacatgttg 780
gccccaggga ctgaaaagct taggaaatgg tattgagaaa tctggggcag ccccaaaagg 840
ggagaggcca tggggagaag ggggggctga gtgggggaaa ggcaggagcc agataaaaag 900
ccagctccag caggcgctgc tcactcctcc ccatcctctc cctctgtccc tctgtccctc 960
tgaccctgca ctgtcccagc accatgggac ccacctcagg tcccagcctg ctgctcctgc 1020
tactaaccca cctccccctg gctctgggga gtcccatgtg agtggttatg actctaccca 1080
caaacagggc t                                                      1091

<210> 6
<211> 1014
<212> DNA
<213> Artificial Sequence

<220> 
<223> HSPA1B Promoter: GH06J031813

<400> 6
gccttaagga cggcctacat actaaggaaa atttttttct aactcctggt tgcagctgag 60
gggagcggct gagggcgggg acaggggtgc ggcggaccca ctgctcccat tacccgacca 120
gcgcctccct tcctccttgg atgggtgccc ctgtcttgct aagaactgcc tgtttacaca 180
actgctttcc ttgtgaaaat ttaaaggctc ctattcccag ttgttctatc cttgtaggtt 240
aaagattatg tcaaaaacta tattgcatta tctctttcct tctccttccc attaagacgg 300
aaaaaacatc cgggagagcc ggtccgtttc tcaggcagac taggccatta ggtgcctcgg 360
agaaaggacc caaggctgct ccgtccttca cagacacagt ccaatcagag tttcccaggc 420
acatcgatgc accgcctcct tcgagaaaca aggtaacttt cgggttctgg ttgtctccaa 480
agtcatccga ccaatctcgc accgcccaga gcgggccctt cctgtcaatt acctactgaa 540
gggcaggcgg ccagcatcgc catggagacc aacacccttc ccaccaccac tccccctttc 600
tctcagggcc cctgtcccct ccagtgaatc ccagaagact ctggagagtt ctgagcagag 660
ggcggcaccc tgccctctga ttggtccaag gaaggctggg gggcaggacg ggaggcgaaa 720
cccctggaat attcccgacc tggcagcctc atcgagcttg gtgattggct cagaagggga 780
aaggcgggtc tccacgacga cttataaaag ccgaggggcg cgcggtccgg aaaacggcca 840
gcctgaggag ctgctgcgag ggtccgcttc gtctttcgag agtgactccc gcggtcccaa 900
ggctttccag agcgaacctg tgcggctgca ggcaccggcg tgttgagttt ccggcgttcc 960
gaaggactga gctcttgtcg cggatcccgt ccgccgtttc cagcccccag tctc       1014

<210> 7
<211> 933
<212> DNA
<213> Artificial Sequence

<220> 
<223> TREM2 promoter: GH06J041163

<400> 7
tgatcaggag ttcaagcatg tgtgtgcaca aaataaacac cagtgtgagc atgtgtgcac 60
aggagacacc caacagttcc aagaaggcta aacttgggca gaaaattcca ggtgggagag 120
aaaattttct gtcttatgga cagcccattt cccttttccc ttctaactag gataatggta 180
atagttagta tttgttgaat gctgtgtgtc aggccctact ggaaagcact ttacctgtag 240
gaacccatat ggtgctcctg ataacccttt gcactatcat tattcccact gtatagatca 300
gggaacagac acaggtaggt tttggatgtg tggttacaca cccagaaagt caggaagtct 360
ggctccagag ctgtgtactt aactgctgcc acactacagg aatgacagcc ctggggggat 420
gaactaagag gtgctggatg agggtcctgg cctctaaagg cacagctgtt ctccaactct 480
tgcaaggctg aaaccagaag atggcgggca ttgcagctgg tggagggtct gaatacagct 540
gtgaggatag tgatccctgg gctaggctct gcaaggaaac tgagcagtgc agggccttac 600
cagccccaac catctggggg ccaccctggc tggcaccagc aggagggtgg gctggcttct 660
cagaggtctg ggagactcag cctccttctg ccagggctgc agtggccgac tcctcctccc 720
ctctgtcccc accctgcacc gcctccagac cccagtcctg actattgctt aatccccagg 780
agcccagttc ctgtgggcag cgcctgacat gcctgatcct ctcttttctg cagttcaagg 840
gaaagacgag atcttgcaca aggcactctg cttctgccct tggctgggga agggtggcat 900
ggagcctctc cggctgctca tcttactctt tgt                              933

<210> 8
<211> 907
<212> DNA
<213> Artificial Sequence

<220> 
<223> IFNgamma promoter

<400> 8
gcagtgctga tctagagcaa tttgaaactt gtggtagata ttttactaac caactctgat 60
gaaggacttc ctcaccaaat tgttctttta accgcattct ttccttgctt tctggtcatt 120
tgcaagaaaa attttaaaag gctgcccctt tgtaaaggtt tgagaggccc tagaatttcg 180
tttttcactt gttcccaacc acaagcaaat gatcaatgtg ctttgtgaat gaagagtcaa 240
cattttacca gggcgaagtg gggaggtaca aaaaaatttc cagtccttga atggtgtgaa 300
gtaaaagtgc cttcaaagaa tcccaccaga atggcacagg tgggcataat gggtctgtct 360
catcgtcaaa ggacccaagg agtctaaagg aaactctaac tacaacaccc aaatgccaca 420
aaaccttagt tattaataca aactatcatc cctgcctatc tgtcaccatc tcatcttaaa 480
aaacttgtga aaatacgtaa tcctcaggag acttcaatta ggtataaata ccagcagcca 540
gaggaggtgc agcacattgt tctgatcatc tgaagatcag ctattagaag agaaagatca 600
gttaagtcct ttggacctga tcagcttgat acaagaacta ctgatttcaa cttctttggc 660
ttaattctct cggaaacgat gaaatataca agttatatct tggcttttca gctctgcatc 720
gttttgggtt ctcttggctg ttactgccag gacccatatg taaaagaagc agaaaacctt 780
aagaaatatt ttgtaagtat gactttttaa tagtacttgt ttgtggttga aaatgactga 840
atatcgactt gctgtagcat ctctgatagg ctgtcatctc ttgtaggcag tcattttgag 900
atttggt                                                           907

<210> 9
<211> 960
<212> DNA
<213> Artificial Sequence

<220> 
<223> TNFalpha promoter

<400> 9
gaggaatggg ttacaggaga cctctgggga gatgtgacca cagcaatggg taggagaatg 60
tccagggcta tggaagtcga gtatggggac ccccccttaa cgaagacagg gccatgtaga 120
gggccccagg gagtgaaaga gcctccagga cctccaggta tggaatacag gggacgttta 180
agaagatatg gccacacact ggggccctga gaagtgagag cttcatgaaa aaaatcaggg 240
accccagagt tccttggaag ccaagactga aaccagcatt atgagtctcc gggtcagaat 300
gaaagaagaa ggcctgcccc agtggggtct gtgaattccc gggggtgatt tcactccccg 360
gggctgtccc aggcttgtcc ctgctacccc cacccagcct ttcctgaggc ctcaagcctg 420
ccaccaagcc cccagctcct tctccccgca gggacccaaa cacaggcctc aggactcaac 480
acagcttttc cctccaaccc cgttttctct ccctcaagga ctcagctttc tgaagcccct 540
cccagttcta gttctatctt tttcctgcat cctgtctgga agttagaagg aaacagacca 600
cagacctggt ccccaaaaga aatggaggca ataggttttg aggggcatgg ggacggggtt 660
cagcctccag ggtcctacac acaaatcagt cagtggccca gaagaccccc ctcggaatcg 720
gagcagggag gatggggagt gtgaggggta tccttgatgc ttgtgtgtcc ccaactttcc 780
aaatccccgc ccccgcgatg gagaagaaac cgagacagaa ggtgcagggc ccactaccgc 840
ttcctccaga tgagctcatg ggtttctcca ccaaggaagt tttccgctgg ttgaatgatt 900
ctttccccgc cctcctctcg ccccagggac atataaaggc agttgttggc acacccagcc 960

<210> 10
<211> 1020
<212> DNA
<213> Artificial Sequence

<220> 
<223> IFNalpha promoter

<400> 10
caatgggttt aatgttgtcc aatgaacata atgtcctcca gctccatcca tgttcttgca 60
aatgacagga tctcattctt ttttatggct aagtagtact ccattgtgta taagtgccat 120
attttcttta tccattcatc tgttagacac ctaagttgct tccaaatctt agctattgtg 180
aatagtgctg caataaacat gggagtgtaa atattttgtt gacatactga tttcatttcc 240
tttggataaa tacccagtag tgggattgct ggatcatatg ggggaaaatg gagatggcta 300
acgggcacaa aaatatagtt agaaaaaatg aatatgattt agtattcgat agcacaatag 360
gatgactact gttaatgata atttattata tattataaaa taactaaaat agtataaatg 420
ggatgtatgt agcagagaga aatgataaat gtttgaagca ttggatactc cattcaccct 480
gctgtgatta ttatgaattg tctgcctata taaaaatatt tcacttattc cataaacaca 540
gacgcctctt atgtacccac aaaaatctat tttcaaaaaa gttgctctaa gaatatagtt 600
atcaagttaa gtaaaatgtc aatagccttt taatttaatt tttaattgtt ttatcattct 660
ttgcaataat aaaacattaa ctttatactt tttaatttaa tgtatagaat agagatatac 720
ataggatatg taaatagata cacagtgtat atgtgattaa aatataatgg gagattcaat 780
cagaaaaaag tttctaaaaa ggctctgggg taaaagagga aggaaacaat aatgaaaaaa 840
atgtggtgag aaaaacagct gaaaacccat gtaaagagtg cataaagaaa gcaaaaagag 900
aagtagaaag taacacaggg gcatttggaa aatgtaaacg agtatgttcc ctatttaagg 960
ctaggcacaa agcaaggtct tcagagaacc tggagcctaa ggtttaggct cacccatttc 1020

<210> 11
<211> 1214
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-6 promoter

<400> 11
agtctagagc ccatttgcat gagaccaagg atcctcctgc aagagacacc atcctgaggg 60
aagagggctt ctgaaccagc ttgacccaat aagaaattct tgggtgccga cgcggaagca 120
gattcagagc ctagagccgt gcctgcgtcc gtagtttcct tctagcttct tttgatttca 180
aatcaagact tacagggaga gggagcgata aacacaaact ctgcaagatg ccacaaggtc 240
ctcctttgac atccccaaca aagaggtgag tagtattctc cccctttctg ccctgaacca 300
agtgggcttc agtaatttca gggctccagg agacctgggg cccatgcagg tgccccagtg 360
aaacagtggt gaagagactc agtggcaatg gggagagcac tggcagcaca aggcaaacct 420
ctggcacaga gagcaaagtc ctcactggga ggattcccaa ggggtcactt gggagagggc 480
agggcagcag ccaacctcct ctaagtgggc tgaagcaggt gaagaaagtg gcagaagcca 540
cgcggtggca aaaaggagtc acacactcca cctggagacg ccttgaagta actgcacgaa 600
atttgaggat ggccaggcag ttctacaaca gccgctcaca gggagagcca gaacacagaa 660
gaactcagat gactggtagt attaccttct tcataatccc aggcttgggg ggctgcgatg 720
gagtcagagg aaactcagtt cagaacatct ttggttttta caaatacaaa ttaactggaa 780
cgctaaattc tagcctgtta atctggtcac tgaaaaaaaa tttttttttt ttcaaaaaac 840
atagctttag cttatttttt ttctctttgt aaaacttcgt gcatgacttc agctttactc 900
tttgtcaaga catgccaaag tgctgagtca ctaataaaag aaaaaaagaa agtaaaggaa 960
gagtggttct gcttcttagc gctagcctca atgacgacct aagctgcact tttcccccta 1020
gttgtgtctt gccatgctaa aggacgtcac attgcacaat cttaataagg tttccaatca 1080
gccccacccg ctctggcccc accctcaccc tccaacaaag atttatcaaa tgtgggattt 1140
tcccatgagt ctcaatatta gagtctcaac ccccaataaa tataggactg gagatgtctg 1200
aggctcattc tgcc                                                   1214

<210> 12
<211> 999
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL-12 promoter:
      GH05J159330

<400> 12
cactttgatt ttcaggggtt ctggaccctg aacatgggtt aaaccagtgg ttctcaaggt 60
gtggtcttag cgccagcagc atctgcttcc cctggaaact ttctagaaat gcatattctc 120
aggccctcat gcctgctgaa tcagacactc tgggggtggg actcagccgt ctgttgtagc 180
agtgcttcca ggttatcctg acagtcactc aaattttaga accactaggt tctctatatg 240
ggagagagta gtctttgaac ttggaaaaca agagaagcta aacccctaca gcaagggctg 300
gtgaccaggt cgttgccaga acctgaaagt tcgcctctgt attaccgttc ctgtccctaa 360
cccaagtcct tcagttctgg gtgctccagc acacactgct ttgtgctgca gtgatacaaa 420
tgtatggctc atctccccag ctggcgggga ggcatttaac acactgactt aataaatatt 480
tattgagtaa aagtatttgc tcctaggaag cgggatccag gtaagccctt tttttctctc 540
tcaactgctt ctagcccagt gctctttatg tagtaagcac taaataaaca actgctagat 600
gttgatccag aaagtcacat tccttctcta agctttaagt ttctcatctt aaaaataaga 660
ggattgtatc agatggcttg ccttaggtct ctttcagctc cagagcccca aataccctat 720
ggttctctat ttagagatgt tcttccccac agactgccat agaactcctg taatttactt 780
agtatttgct tgacagtatg gagaagaaag gggagaatca agattttatt taaaaaaaaa 840
gtagctagaa tgtgtatatg gttcacaaag gtaacaagaa ttattgacat tctttcttct 900
cttttttctt cctcttcctt ctcttttcct ccttctcttc cccctgcttc tctcccttct 960
tatagatgtg tcaccagcag ttggtcatct cttggtttt                        999

<210> 13
<211> 498
<212> PRT
<213> Artificial Sequence

<220> 
<223> M-CSF R, extracellular: aa 20-517

<400> 13
Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val Lys Pro Gly
 1               5                  10                  15      
Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val Glu Trp Asp
            20                  25                  30          
Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly Ser Ser Ser
        35                  40                  45              
Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly Thr Tyr Arg
    50                  55                  60                  
Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala Ile His Leu
65                  70                  75                  80  
Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala Gln Glu Val
                85                  90                  95      
Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu Leu Thr Asp
            100                 105                 110         
Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg Gly Arg Pro
        115                 120                 125             
Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His Gly Phe Thr
    130                 135                 140                 
Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln Cys Ser Ala
145                 150                 155                 160 
Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg Leu Lys Val
                165                 170                 175     
Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val Pro Ala Glu
            180                 185                 190         
Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys Ser Ala Ser
        195                 200                 205             
Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn Asn Thr Lys
    210                 215                 220                 
Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg Tyr Gln Lys
225                 230                 235                 240 
Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His Ala Gly Asn
                245                 250                 255     
Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser Thr Ser Met
            260                 265                 270         
Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser Ser Glu Gln
        275                 280                 285             
Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn Leu Lys Val
    290                 295                 300                 
Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp Thr Tyr Leu
305                 310                 315                 320 
Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala Asn Ala Thr
                325                 330                 335     
Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu Pro Arg Leu
            340                 345                 350         
Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg Asn Pro Gly
        355                 360                 365             
Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr Pro Pro Glu
    370                 375                 380                 
Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr Leu Leu Cys
385                 390                 395                 400 
Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu Gln Cys Ser
                405                 410                 415     
Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln Val Trp Asp
            420                 425                 430         
Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His Lys Val Thr
        435                 440                 445             
Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn Gln Thr Tyr
    450                 455                 460                 
Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp Ala Phe Ile
465                 470                 475                 480 
Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu Phe Leu Phe
                485                 490                 495     
Thr Pro

<210> 14
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> M-CSF R, transmembrane: aa 518-538

<400> 14
Val Val Val Ala Cys Met Ser Ile Met Ala Leu Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Leu Leu Leu Tyr
            20

<210> 15
<211> 329
<212> PRT
<213> Artificial Sequence

<220> 
<223> M-CSF R, intracellular: aa 586-910

<400> 15
Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val
 1               5                  10                  15      
Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp Ala Val Leu Lys Val
            20                  25                  30          
Ala Val Lys Met Leu Lys Ser Thr Ala His Ala Asp Glu Lys Glu Ala
        35                  40                  45              
Leu Met Ser Glu Leu Lys Ile Met Ser His Leu Gly Gln His Glu Asn
    50                  55                  60                  
Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly Gly Pro Val Leu Val
65                  70                  75                  80  
Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg
                85                  90                  95      
Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser Pro Gly Gln Asp Pro
            100                 105                 110         
Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu Glu Lys Lys Tyr Val
        115                 120                 125             
Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val Asp Thr Tyr Val Glu
    130                 135                 140                 
Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser Phe Ser Glu Gln Asp
145                 150                 155                 160 
Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu Arg Asp Leu Leu His
                165                 170                 175     
Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe Leu Ala Ser Lys Asn
            180                 185                 190         
Cys Ile His Arg Asp Val Ala Ala Arg Asn Val Leu Leu Thr Asn Gly
        195                 200                 205             
His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala Arg Asp Ile Met Asn
    210                 215                 220                 
Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg Leu Pro Val Lys Trp
225                 230                 235                 240 
Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr Thr Val Gln Ser Asp
                245                 250                 255     
Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Leu
            260                 265                 270         
Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys Phe Tyr Lys Leu Val
        275                 280                 285             
Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe Ala Pro Lys Asn Ile
    290                 295                 300                 
Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu Pro Thr His Arg Pro
305                 310                 315                 320 
Thr Phe Gln Gln Ile Cys Ser Phe Leu
                325

<210> 16
<211> 352
<212> PRT
<213> Artificial Sequence

<220> 
<223> CXCR4

<400> 16
Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met
 1               5                  10                  15      
Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu
            20                  25                  30          
Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile
        35                  40                  45              
Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly
    50                  55                  60                  
Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu
65                  70                  75                  80  
Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val
                85                  90                  95      
Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val
            100                 105                 110         
His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala
        115                 120                 125             
Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser
    130                 135                 140                 
Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val
145                 150                 155                 160 
Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn
                165                 170                 175     
Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn
            180                 185                 190         
Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu
        195                 200                 205             
Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser
    210                 215                 220                 
Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr
225                 230                 235                 240 
Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr
                245                 250                 255     
Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln
            260                 265                 270         
Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu
        275                 280                 285             
Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe
    290                 295                 300                 
Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val
305                 310                 315                 320 
Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly
                325                 330                 335     
His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser
            340                 345                 350

<210> 17
<211> 844
<212> PRT
<213> Artificial Sequence

<220> 
<223> Neuropilin (NRP2): Binds SEMA3A, extracellular: aa
      21-864

<400> 17
Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu Asn Ser Lys Asp
 1               5                  10                  15      
Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp Tyr Pro Ser His
            20                  25                  30          
Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro Asn Gln Lys Ile
        35                  40                  45              
Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys His Asp Cys Lys
    50                  55                  60                  
Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu Ser Ala Asp Leu
65                  70                  75                  80  
Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr Ile Ile Ser Ser
                85                  90                  95      
Gly Ser Met Leu Tyr Ile Lys Phe Thr Ser Asp Tyr Ala Arg Gln Gly
            100                 105                 110         
Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr Gly Ser Glu Asp
        115                 120                 125             
Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile Glu Ser Pro Gly
    130                 135                 140                 
Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr Phe Thr Ile Leu
145                 150                 155                 160 
Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu Ile Phe Asp Leu
                165                 170                 175     
Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys Lys Tyr Asp Trp
            180                 185                 190         
Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro Leu Ile Gly Lys
        195                 200                 205             
Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser Ser Thr Gly Ile
    210                 215                 220                 
Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala Lys Asp Gly Phe
225                 230                 235                 240 
Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln
                245                 250                 255     
Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile Ala Asn Glu Gln
            260                 265                 270         
Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp Thr Pro Gln Gln
        275                 280                 285             
Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro Asn Leu Asp Ser
    290                 295                 300                 
Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu Thr Met Leu Thr
305                 310                 315                 320 
Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr Gln Asn Gly Tyr
                325                 330                 335     
Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn Gly Glu Asp Trp
            340                 345                 350         
Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe Gln Ala Asn Asn
        355                 360                 365             
Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala Pro Leu Leu Thr
    370                 375                 380                 
Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu
385                 390                 395                 400 
Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala Pro Cys Ser Asn
                405                 410                 415     
Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser Gln Ile Ser Ala
            420                 425                 430         
Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala Ala Arg Leu Val
        435                 440                 445             
Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln Ala Gln Pro Gly
    450                 455                 460                 
Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys Thr Val Lys Gly
465                 470                 475                 480 
Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile Thr Ala Val Glu
                485                 490                 495     
Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr Ser Leu Asn Gly
            500                 505                 510         
Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln Gln Pro Lys Leu
        515                 520                 525             
Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile Arg Arg Phe Asp
    530                 535                 540                 
Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu Arg Trp Ser Pro
545                 550                 555                 560 
Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys Asp Trp Thr Asp
                565                 570                 575     
Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val Lys Ser Glu Glu
            580                 585                 590         
Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr Glu Cys Gly Glu
        595                 600                 605             
Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu Pro Ser Gly Phe
    610                 615                 620                 
Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly Trp Met Tyr Asp
625                 630                 635                 640 
His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser Ser Ser Pro Asn
                645                 650                 655     
Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg Leu Gln Ser Asp
            660                 665                 670         
Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser Pro Pro Val His
        675                 680                 685             
Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr Gln Ala Thr Gly
    690                 695                 700                 
Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala Ser Gln Glu Ser
705                 710                 715                 720 
Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly Glu Trp Lys His
                725                 730                 735     
Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr Gln Ile Val Phe
            740                 745                 750         
Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile Ala Ile Asp Asp
        755                 760                 765             
Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys Met Glu Pro Ile
    770                 775                 780                 
Ser Ala Phe Ala Gly Glu Asn Phe Lys Val Asp Ile Pro Glu Ile His
785                 790                 795                 800 
Glu Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu Tyr Glu Val Asp
                805                 810                 815     
Trp Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly Ala Pro Ser Thr
            820                 825                 830         
Asp Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro
        835                 840

<210> 18
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Neuropilin (NRP2): Binds SEMA3A, transmembrane: aa
      865-889

<400> 18
Ile Leu Ile Thr Ile Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly
 1               5                  10                  15      
Ala Thr Cys Ala Gly Leu Leu Leu Tyr
            20                  25

<210> 19
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> Neuropilin (NRP2): Binds SEMA3A, cytoplasmic: aa
      890-931

<400> 19
Cys Thr Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser Cys Thr Thr Leu
 1               5                  10                  15      
Glu Asn Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys His Lys Val Lys
            20                  25                  30          
Met Asn His Gln Lys Cys Cys Ser Glu Ala
        35                  40

<210> 20
<211> 621
<212> PRT
<213> Artificial Sequence

<220> 
<223> Epidermal Growth Factor receptor: EGFR:
      extracellular: aa 25-645

<400> 20
Leu Glu Glu Lys Lys Val Cys Gln Gly Thr Ser Asn Lys Leu Thr Gln
 1               5                  10                  15      
Leu Gly Thr Phe Glu Asp His Phe Leu Ser Leu Gln Arg Met Phe Asn
            20                  25                  30          
Asn Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr Val Gln Arg
        35                  40                  45              
Asn Tyr Asp Leu Ser Phe Leu Lys Thr Ile Gln Glu Val Ala Gly Tyr
    50                  55                  60                  
Val Leu Ile Ala Leu Asn Thr Val Glu Arg Ile Pro Leu Glu Asn Leu
65                  70                  75                  80  
Gln Ile Ile Arg Gly Asn Met Tyr Tyr Glu Asn Ser Tyr Ala Leu Ala
                85                  90                  95      
Val Leu Ser Asn Tyr Asp Ala Asn Lys Thr Gly Leu Lys Glu Leu Pro
            100                 105                 110         
Met Arg Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg Phe Ser Asn
        115                 120                 125             
Asn Pro Ala Leu Cys Asn Val Glu Ser Ile Gln Trp Arg Asp Ile Val
    130                 135                 140                 
Ser Ser Asp Phe Leu Ser Asn Met Ser Met Asp Phe Gln Asn His Leu
145                 150                 155                 160 
Gly Ser Cys Gln Lys Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp
                165                 170                 175     
Gly Ala Gly Glu Glu Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala
            180                 185                 190         
Gln Gln Cys Ser Gly Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys
        195                 200                 205             
His Asn Gln Cys Ala Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys
    210                 215                 220                 
Leu Val Cys Arg Lys Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys
225                 230                 235                 240 
Pro Pro Leu Met Leu Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn
                245                 250                 255     
Pro Glu Gly Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro
            260                 265                 270         
Arg Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly
        275                 280                 285             
Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys
    290                 295                 300                 
Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu
305                 310                 315                 320 
Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys
                325                 330                 335     
Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe
            340                 345                 350         
Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu
        355                 360                 365             
Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln
    370                 375                 380                 
Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu
385                 390                 395                 400 
Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val
                405                 410                 415     
Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile
            420                 425                 430         
Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala
        435                 440                 445             
Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr
    450                 455                 460                 
Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln
465                 470                 475                 480 
Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro
                485                 490                 495     
Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val
            500                 505                 510         
Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn
        515                 520                 525             
Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn
    530                 535                 540                 
Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His
545                 550                 555                 560 
Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met
                565                 570                 575     
Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val
            580                 585                 590         
Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly
        595                 600                 605             
Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser
    610                 615                 620

<210> 21
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Epidermal Growth Factor receptor: EGFR:
      transmembrane: aa 646-668

<400> 21
Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala
 1               5                  10                  15      
Leu Gly Ile Gly Leu Phe Met
            20

<210> 22
<211> 542
<212> PRT
<213> Artificial Sequence

<220> 
<223> Epidermal Growth Factor receptor: EGFR:
      Intracellular

<400> 22
Arg Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln
 1               5                  10                  15      
Glu Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn
            20                  25                  30          
Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys
        35                  40                  45              
Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile
    50                  55                  60                  
Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg
65                  70                  75                  80  
Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr
                85                  90                  95      
Val Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile
            100                 105                 110         
Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly
        115                 120                 125             
Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln
    130                 135                 140                 
Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu
145                 150                 155                 160 
Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu
                165                 170                 175     
Val Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys
            180                 185                 190         
Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val
        195                 200                 205             
Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr
    210                 215                 220                 
His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met
225                 230                 235                 240 
Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser
                245                 250                 255     
Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr
            260                 265                 270         
Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp
        275                 280                 285             
Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala
    290                 295                 300                 
Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His
305                 310                 315                 320 
Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu
                325                 330                 335     
Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln
            340                 345                 350         
Gln Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser
        355                 360                 365             
Ser Leu Ser Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg
    370                 375                 380                 
Asn Gly Leu Gln Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg
385                 390                 395                 400 
Tyr Ser Ser Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp Asp
                405                 410                 415     
Thr Phe Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg
            420                 425                 430         
Pro Ala Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn
        435                 440                 445             
Pro Ala Pro Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala
    450                 455                 460                 
Val Gly Asn Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn
465                 470                 475                 480 
Ser Thr Phe Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln
                485                 490                 495     
Ile Ser Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu
            500                 505                 510         
Ala Lys Pro Asn Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu
        515                 520                 525             
Tyr Leu Arg Val Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala
    530                 535                 540

<210> 23
<211> 745
<212> PRT
<213> Artificial Sequence

<220> 
<223> Vascular Endothelial Growth Factor Receptor 2,
      extracellular: aa 20-764

<400> 23
Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro Arg Leu Ser
 1               5                  10                  15      
Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr Leu Gln Ile
            20                  25                  30          
Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro Asn Asn Gln
        35                  40                  45              
Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser Asp Gly Leu
    50                  55                  60                  
Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn Asp Thr Gly
65                  70                  75                  80  
Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser Val Ile Tyr
                85                  90                  95      
Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser Val Ser Asp
            100                 105                 110         
Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys Thr Val Val
        115                 120                 125             
Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser Leu Cys Ala
    130                 135                 140                 
Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg Ile Ser Trp
145                 150                 155                 160 
Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile Ser Tyr Ala
                165                 170                 175     
Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser Tyr Gln Ser
            180                 185                 190         
Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr Asp Val Val
        195                 200                 205             
Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu Lys Leu Val
    210                 215                 220                 
Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile Asp Phe Asn
225                 230                 235                 240 
Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu Val Asn Arg
                245                 250                 255     
Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe Leu Ser Thr
            260                 265                 270         
Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr Cys
        275                 280                 285             
Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr Phe Val Arg
    290                 295                 300                 
Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met Glu Ser Leu
305                 310                 315                 320 
Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala Lys Tyr Leu
                325                 330                 335     
Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly Ile Pro Leu
            340                 345                 350         
Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr Ile Met Glu
        355                 360                 365             
Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu Thr Asn Pro
    370                 375                 380                 
Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val Val Tyr Val
385                 390                 395                 400 
Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val Asp Ser Tyr
                405                 410                 415     
Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr Ala Ile Pro
            420                 425                 430         
Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu Glu Cys Ala
        435                 440                 445             
Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr Pro Cys Glu
    450                 455                 460                 
Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys Ile Glu Val
465                 470                 475                 480 
Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys Thr Val Ser
                485                 490                 495     
Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr Lys Cys Glu
            500                 505                 510         
Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser Phe His Val
        515                 520                 525             
Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln Pro Thr Glu
    530                 535                 540                 
Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser Thr Phe Glu
545                 550                 555                 560 
Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro Ile His Val
                565                 570                 575     
Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr Leu Trp Lys
            580                 585                 590         
Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile Leu Ile Met
        595                 600                 605             
Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr Val Cys Leu
    610                 615                 620                 
Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val Arg Gln Leu
625                 630                 635                 640 
Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn Leu Glu Asn
                645                 650                 655     
Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys Thr Ala Ser
            660                 665                 670         
Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn Glu Thr Leu
        675                 680                 685             
Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg Asn Leu Thr
    690                 695                 700                 
Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr Cys Gln Ala
705                 710                 715                 720 
Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe Ile Ile Glu
                725                 730                 735     
Gly Ala Gln Glu Lys Thr Asn Leu Glu
            740                 745

<210> 24
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Vascular Endothelial Growth Factor Receptor 2,
      transmembrane: aa 765-785

<400> 24
Ile Ile Ile Leu Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu
 1               5                  10                  15      
Leu Leu Val Ile Ile
            20

<210> 25
<211> 571
<212> PRT
<213> Artificial Sequence

<220> 
<223> Vascular Endothelial Growth Factor Receptor 2,
      intracellular: aa 786-1356

<400> 25
Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly Tyr
 1               5                  10                  15      
Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His Cys
            20                  25                  30          
Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp Arg
        35                  40                  45              
Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val Ile
    50                  55                  60                  
Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr Val
65                  70                  75                  80  
Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg Ala
                85                  90                  95      
Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu Asn
            100                 105                 110         
Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu Met
        115                 120                 125             
Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu Arg
    130                 135                 140                 
Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg Phe
145                 150                 155                 160 
Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys Arg
                165                 170                 175     
Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly Phe
            180                 185                 190         
Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro Glu
        195                 200                 205             
Asp Leu Tyr Lys Asp Phe Leu Thr Leu Glu His Leu Ile Cys Tyr Ser
    210                 215                 220                 
Phe Gln Val Ala Lys Gly Met Glu Phe Leu Ala Ser Arg Lys Cys Ile
225                 230                 235                 240 
His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Ser Glu Lys Asn Val
                245                 250                 255     
Val Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Tyr Lys Asp Pro
            260                 265                 270         
Asp Tyr Val Arg Lys Gly Asp Ala Arg Leu Pro Leu Lys Trp Met Ala
        275                 280                 285             
Pro Glu Thr Ile Phe Asp Arg Val Tyr Thr Ile Gln Ser Asp Val Trp
    290                 295                 300                 
Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly Ala Ser Pro
305                 310                 315                 320 
Tyr Pro Gly Val Lys Ile Asp Glu Glu Phe Cys Arg Arg Leu Lys Glu
                325                 330                 335     
Gly Thr Arg Met Arg Ala Pro Asp Tyr Thr Thr Pro Glu Met Tyr Gln
            340                 345                 350         
Thr Met Leu Asp Cys Trp His Gly Glu Pro Ser Gln Arg Pro Thr Phe
        355                 360                 365             
Ser Glu Leu Val Glu His Leu Gly Asn Leu Leu Gln Ala Asn Ala Gln
    370                 375                 380                 
Gln Asp Gly Lys Asp Tyr Ile Val Leu Pro Ile Ser Glu Thr Leu Ser
385                 390                 395                 400 
Met Glu Glu Asp Ser Gly Leu Ser Leu Pro Thr Ser Pro Val Ser Cys
                405                 410                 415     
Met Glu Glu Glu Glu Val Cys Asp Pro Lys Phe His Tyr Asp Asn Thr
            420                 425                 430         
Ala Gly Ile Ser Gln Tyr Leu Gln Asn Ser Lys Arg Lys Ser Arg Pro
        435                 440                 445             
Val Ser Val Lys Thr Phe Glu Asp Ile Pro Leu Glu Glu Pro Glu Val
    450                 455                 460                 
Lys Val Ile Pro Asp Asp Asn Gln Thr Asp Ser Gly Met Val Leu Ala
465                 470                 475                 480 
Ser Glu Glu Leu Lys Thr Leu Glu Asp Arg Thr Lys Leu Ser Pro Ser
                485                 490                 495     
Phe Gly Gly Met Val Pro Ser Lys Ser Arg Glu Ser Val Ala Ser Glu
            500                 505                 510         
Gly Ser Asn Gln Thr Ser Gly Tyr Gln Ser Gly Tyr His Ser Asp Asp
        515                 520                 525             
Thr Asp Thr Thr Val Tyr Ser Ser Glu Glu Ala Glu Leu Leu Lys Leu
    530                 535                 540                 
Ile Glu Ile Gly Val Gln Thr Gly Ser Thr Ala Gln Ile Leu Gln Pro
545                 550                 555                 560 
Asp Ser Gly Thr Thr Leu Ser Ser Pro Pro Val
                565                 570

<210> 26
<211> 144
<212> PRT
<213> Artificial Sequence

<220> 
<223> Transforming Growth Factor beta Receptor 2:
      P37173, extracellular: aa 23-166

<400> 26
Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val
 1               5                  10                  15      
Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys
            20                  25                  30          
Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn
        35                  40                  45              
Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala
    50                  55                  60                  
Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His
65                  70                  75                  80  
Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser
                85                  90                  95      
Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe
            100                 105                 110         
Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser
        115                 120                 125             
Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln
    130                 135                 140

<210> 27
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Transforming Growth Factor beta Receptor 2:
      P37173, transmembrane aa 167-187

<400> 27
Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val
 1               5                  10                  15      
Ile Ile Ile Phe Tyr
            20

<210> 28
<211> 380
<212> PRT
<213> Artificial Sequence

<220> 
<223> Transforming Growth Factor beta Receptor 2:
      P37173, intracellular : aa 188-567

<400> 28
Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr
 1               5                  10                  15      
Gly Lys Thr Arg Lys Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile
            20                  25                  30          
Leu Glu Asp Asp Arg Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile
        35                  40                  45              
Asn His Asn Thr Glu Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly
    50                  55                  60                  
Lys Gly Arg Phe Ala Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr
65                  70                  75                  80  
Ser Glu Gln Phe Glu Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu
                85                  90                  95      
Tyr Ala Ser Trp Lys Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu
            100                 105                 110         
Lys His Glu Asn Ile Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr
        115                 120                 125             
Glu Leu Gly Lys Gln Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly
    130                 135                 140                 
Asn Leu Gln Glu Tyr Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu
145                 150                 155                 160 
Arg Lys Leu Gly Ser Ser Leu Ala Arg Gly Ile Ala His Leu His Ser
                165                 170                 175     
Asp His Thr Pro Cys Gly Arg Pro Lys Met Pro Ile Val His Arg Asp
            180                 185                 190         
Leu Lys Ser Ser Asn Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu
        195                 200                 205             
Cys Asp Phe Gly Leu Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp
    210                 215                 220                 
Asp Leu Ala Asn Ser Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro
225                 230                 235                 240 
Glu Val Leu Glu Ser Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys
                245                 250                 255     
Gln Thr Asp Val Tyr Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser
            260                 265                 270         
Arg Cys Asn Ala Val Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly
        275                 280                 285             
Ser Lys Val Arg Glu His Pro Cys Val Glu Ser Met Lys Asp Asn Val
    290                 295                 300                 
Leu Arg Asp Arg Gly Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His
305                 310                 315                 320 
Gln Gly Ile Gln Met Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His
                325                 330                 335     
Asp Pro Glu Ala Arg Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser
            340                 345                 350         
Glu Leu Glu His Leu Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu
        355                 360                 365             
Lys Ile Pro Glu Asp Gly Ser Leu Asn Thr Thr Lys
    370                 375                 380

<210> 29
<211> 182
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tumor necrosis factor alpha receptor (P19348) ,
      extracellular: aa 30-211

<400> 29
Leu Val Pro His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro
 1               5                  10                  15      
Gln Gly Lys Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys
            20                  25                  30          
Cys His Lys Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln
        35                  40                  45              
Asp Thr Asp Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu
    50                  55                  60                  
Asn His Leu Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met
65                  70                  75                  80  
Gly Gln Val Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys
                85                  90                  95      
Gly Cys Arg Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe
            100                 105                 110         
Gln Cys Phe Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser
        115                 120                 125             
Cys Gln Glu Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe
    130                 135                 140                 
Leu Arg Glu Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu
145                 150                 155                 160 
Glu Cys Thr Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr
                165                 170                 175     
Glu Asp Ser Gly Thr Thr
            180

<210> 30
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tumor necrosis factor alpha receptor (P19348),
      transmembrane: aa 212-232

<400> 30
Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu Leu Ser Leu
 1               5                  10                  15      
Leu Phe Ile Gly Leu
            20

<210> 31
<211> 223
<212> PRT
<213> Artificial Sequence

<220> 
<223> Tumor necrosis factor alpha receptor (P19348),
      intracellular: aa 233-455

<400> 31
Met Tyr Arg Tyr Gln Arg Trp Lys Ser Lys Leu Tyr Ser Ile Val Cys
 1               5                  10                  15      
Gly Lys Ser Thr Pro Glu Lys Glu Gly Glu Leu Glu Gly Thr Thr Thr
            20                  25                  30          
Lys Pro Leu Ala Pro Asn Pro Ser Phe Ser Pro Thr Pro Gly Phe Thr
        35                  40                  45              
Pro Thr Leu Gly Phe Ser Pro Val Pro Ser Ser Thr Phe Thr Ser Ser
    50                  55                  60                  
Ser Thr Tyr Thr Pro Gly Asp Cys Pro Asn Phe Ala Ala Pro Arg Arg
65                  70                  75                  80  
Glu Val Ala Pro Pro Tyr Gln Gly Ala Asp Pro Ile Leu Ala Thr Ala
                85                  90                  95      
Leu Ala Ser Asp Pro Ile Pro Asn Pro Leu Gln Lys Trp Glu Asp Ser
            100                 105                 110         
Ala His Lys Pro Gln Ser Leu Asp Thr Asp Asp Pro Ala Thr Leu Tyr
        115                 120                 125             
Ala Val Val Glu Asn Val Pro Pro Leu Arg Trp Lys Glu Phe Val Arg
    130                 135                 140                 
Arg Leu Gly Leu Ser Asp His Glu Ile Asp Arg Leu Glu Leu Gln Asn
145                 150                 155                 160 
Gly Arg Cys Leu Arg Glu Ala Gln Tyr Ser Met Leu Ala Thr Trp Arg
                165                 170                 175     
Arg Arg Thr Pro Arg Arg Glu Ala Thr Leu Glu Leu Leu Gly Arg Val
            180                 185                 190         
Leu Arg Asp Met Asp Leu Leu Gly Cys Leu Glu Asp Ile Glu Glu Ala
        195                 200                 205             
Leu Cys Gly Pro Ala Ala Leu Pro Pro Ala Pro Ser Leu Leu Arg
    210                 215                 220

<210> 32
<211> 346
<212> PRT
<213> Artificial Sequence

<220> 
<223> Interleukin 6 receptor (P08887): extracellular: aa
      20-365

<400> 32
Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg Gly Val Leu
 1               5                  10                  15      
Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro Gly Val Glu
            20                  25                  30          
Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys Pro Ala Ala
        35                  40                  45              
Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg Leu Leu Leu
    50                  55                  60                  
Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys Tyr Arg Ala
65                  70                  75                  80  
Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val Pro Pro Glu
                85                  90                  95      
Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser Asn Val Val
            100                 105                 110         
Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr Lys Ala Val
        115                 120                 125             
Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp Phe Gln Glu
    130                 135                 140                 
Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys Gln Leu Ala
145                 150                 155                 160 
Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met Cys Val Ala
                165                 170                 175     
Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe Gln Gly Cys
            180                 185                 190         
Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val Thr Ala Val
        195                 200                 205             
Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp Pro His Ser
    210                 215                 220                 
Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg Tyr Arg Ala
225                 230                 235                 240 
Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp Leu Gln His
                245                 250                 255     
His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His Val Val Gln
            260                 265                 270         
Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser Glu Trp Ser
        275                 280                 285             
Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser Pro Pro Ala
    290                 295                 300                 
Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr Asn Lys Asp
305                 310                 315                 320 
Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr Ser Leu Pro
                325                 330                 335     
Val Gln Asp Ser Ser Ser Val Pro Leu Pro
            340                 345

<210> 33
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Interleukin 6 receptor (P08887): transmembrane: aa
      366-386

<400> 33
Thr Phe Leu Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys
 1               5                  10                  15      
Ile Ala Ile Val Leu
            20

<210> 34
<211> 82
<212> PRT
<213> Artificial Sequence

<220> 
<223> Interleukin 6 receptor (P08887): intracellular: aa
      387-468

<400> 34
Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly Lys Thr
 1               5                  10                  15      
Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu Arg Pro
            20                  25                  30          
Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val Ser Pro
        35                  40                  45              
Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro Asp Ala
    50                  55                  60                  
Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr Phe Phe
65                  70                  75                  80  
Pro Arg

<210> 35
<211> 228
<212> PRT
<213> Artificial Sequence

<220> 
<223> Interferon gamma receptor 2 (P15260):
      extracellular: aa 18-245

<400> 35
Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro Thr
 1               5                  10                  15      
Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp Glu
            20                  25                  30          
Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys Asn
        35                  40                  45              
Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile Ser
    50                  55                  60                  
His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn Ser
65                  70                  75                  80  
Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala Tyr
                85                  90                  95      
Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly Pro
            100                 105                 110         
Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp Ile
        115                 120                 125             
Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp Tyr
    130                 135                 140                 
Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val Arg
145                 150                 155                 160 
Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu Asp
                165                 170                 175     
Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser Leu
            180                 185                 190         
Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp Gly
        195                 200                 205             
Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn Ser
    210                 215                 220                 
Ser Ile Lys Gly
225

<210> 36
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Interferon gamma receptor 2 (P15260):
      transmembrane: aa 246-266

<400> 36
Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu Leu Phe Leu Val Leu
 1               5                  10                  15      
Ser Leu Val Phe Ile
            20

<210> 37
<211> 223
<212> PRT
<213> Artificial Sequence

<220> 
<223> Interferon gamma receptor 2 (P15260): cytoplasmic:
      aa 267-489

<400> 37
Cys Phe Tyr Ile Lys Lys Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile
 1               5                  10                  15      
Leu Pro Lys Ser Leu Ile Ser Val Val Arg Ser Ala Thr Leu Glu Thr
            20                  25                  30          
Lys Pro Glu Ser Lys Tyr Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe
        35                  40                  45              
Ser Leu Glu Lys Glu Val Val Cys Glu Glu Pro Leu Ser Pro Ala Thr
    50                  55                  60                  
Val Pro Gly Met His Thr Glu Asp Asn Pro Gly Lys Val Glu His Thr
65                  70                  75                  80  
Glu Glu Leu Ser Ser Ile Thr Glu Val Val Thr Thr Glu Glu Asn Ile
                85                  90                  95      
Pro Asp Val Val Pro Gly Ser His Leu Thr Pro Ile Glu Arg Glu Ser
            100                 105                 110         
Ser Ser Pro Leu Ser Ser Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu
        115                 120                 125             
Asn Ser Tyr His Ser Arg Asn Cys Ser Glu Ser Asp His Ser Arg Asn
    130                 135                 140                 
Gly Phe Asp Thr Asp Ser Ser Cys Leu Glu Ser His Ser Ser Leu Ser
145                 150                 155                 160 
Asp Ser Glu Phe Pro Pro Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly
                165                 170                 175     
Gln Glu Leu Ile Thr Val Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp
            180                 185                 190         
Lys Pro His Val Leu Val Asp Leu Leu Val Asp Asp Ser Gly Lys Glu
        195                 200                 205             
Ser Leu Ile Gly Tyr Arg Pro Thr Glu Asp Ser Lys Glu Phe Ser
    210                 215                 220

<210> 38
<211> 298
<212> PRT
<213> Artificial Sequence

<220> 
<223> Granulocyte-macrophages colony-stimulating factor
      receptor subunit alpha (P15509), extracellular: aa
      23-320

<400> 38
Glu Lys Ser Asp Leu Arg Thr Val Ala Pro Ala Ser Ser Leu Asn Val
 1               5                  10                  15      
Arg Phe Asp Ser Arg Thr Met Asn Leu Ser Trp Asp Cys Gln Glu Asn
            20                  25                  30          
Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp Lys Lys Asn Arg Val Val
        35                  40                  45              
Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser Cys Thr Phe Arg Glu Ile
    50                  55                  60                  
Cys Leu His Glu Gly Val Thr Phe Glu Val His Val Asn Thr Ser Gln
65                  70                  75                  80  
Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro Asn Ser Gly Arg Glu Gly
                85                  90                  95      
Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile Tyr Asn Ala Asp Leu Met
            100                 105                 110         
Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala Pro Arg Asp Val Gln Tyr
        115                 120                 125             
Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg Arg Glu Ile Arg Cys Pro
    130                 135                 140                 
Tyr Tyr Ile Gln Asp Ser Gly Thr His Val Gly Cys His Leu Asp Asn
145                 150                 155                 160 
Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe Leu Val Asn Gly Thr Ser
                165                 170                 175     
Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser Leu Leu Asp Thr Lys Lys
            180                 185                 190         
Ile Glu Arg Phe Asn Pro Pro Ser Asn Val Thr Val Arg Cys Asn Thr
        195                 200                 205             
Thr His Cys Leu Val Arg Trp Lys Gln Pro Arg Thr Tyr Gln Lys Leu
    210                 215                 220                 
Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp Val His Arg Lys Asn Thr
225                 230                 235                 240 
Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn Val Ser Gly Asp Leu Glu
                245                 250                 255     
Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro Arg Ala Lys His Ser Val
            260                 265                 270         
Lys Ile Arg Ala Ala Asp Val Arg Ile Leu Asn Trp Ser Ser Trp Ser
        275                 280                 285             
Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly
    290                 295

<210> 39
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Granulocyte-macrophages colony-stimulating factor
      receptor subunit alpha (P15509), transmembrane: aa
      321-346

<400> 39
Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu
 1               5                  10                  15      
Val Cys Gly Ile Val Leu Gly Phe Leu Phe
            20                  25

<210> 40
<211> 54
<212> PRT
<213> Artificial Sequence

<220> 
<223> Granulocyte-macrophages colony-stimulating factor
      receptor subunit alpha (P15509), cytoplasmic: aa
      347-400

<400> 40
Lys Arg Phe Leu Arg Ile Gln Arg Leu Phe Pro Pro Val Pro Gln Ile
 1               5                  10                  15      
Lys Asp Lys Leu Asn Asp Asn His Glu Val Glu Asp Glu Ile Ile Trp
            20                  25                  30          
Glu Glu Phe Thr Pro Glu Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu
        35                  40                  45              
Thr Val Lys Glu Ile Thr
    50

<210> 41
<211> 608
<212> PRT
<213> Artificial Sequence

<220> 
<223> Toll Like Receptor 4: extracellular aa 24-631

<400> 41
Glu Ser Trp Glu Pro Cys Val Glu Val Val Pro Asn Ile Thr Tyr Gln
 1               5                  10                  15      
Cys Met Glu Leu Asn Phe Tyr Lys Ile Pro Asp Asn Leu Pro Phe Ser
            20                  25                  30          
Thr Lys Asn Leu Asp Leu Ser Phe Asn Pro Leu Arg His Leu Gly Ser
        35                  40                  45              
Tyr Ser Phe Phe Ser Phe Pro Glu Leu Gln Val Leu Asp Leu Ser Arg
    50                  55                  60                  
Cys Glu Ile Gln Thr Ile Glu Asp Gly Ala Tyr Gln Ser Leu Ser His
65                  70                  75                  80  
Leu Ser Thr Leu Ile Leu Thr Gly Asn Pro Ile Gln Ser Leu Ala Leu
                85                  90                  95      
Gly Ala Phe Ser Gly Leu Ser Ser Leu Gln Lys Leu Val Ala Val Glu
            100                 105                 110         
Thr Asn Leu Ala Ser Leu Glu Asn Phe Pro Ile Gly His Leu Lys Thr
        115                 120                 125             
Leu Lys Glu Leu Asn Val Ala His Asn Leu Ile Gln Ser Phe Lys Leu
    130                 135                 140                 
Pro Glu Tyr Phe Ser Asn Leu Thr Asn Leu Glu His Leu Asp Leu Ser
145                 150                 155                 160 
Ser Asn Lys Ile Gln Ser Ile Tyr Cys Thr Asp Leu Arg Val Leu His
                165                 170                 175     
Gln Met Pro Leu Leu Asn Leu Ser Leu Asp Leu Ser Leu Asn Pro Met
            180                 185                 190         
Asn Phe Ile Gln Pro Gly Ala Phe Lys Glu Ile Arg Leu His Lys Leu
        195                 200                 205             
Thr Leu Arg Asn Asn Phe Asp Ser Leu Asn Val Met Lys Thr Cys Ile
    210                 215                 220                 
Gln Gly Leu Ala Gly Leu Glu Val His Arg Leu Val Leu Gly Glu Phe
225                 230                 235                 240 
Arg Asn Glu Gly Asn Leu Glu Lys Phe Asp Lys Ser Ala Leu Glu Gly
                245                 250                 255     
Leu Cys Asn Leu Thr Ile Glu Glu Phe Arg Leu Ala Tyr Leu Asp Tyr
            260                 265                 270         
Tyr Leu Asp Asp Ile Ile Asp Leu Phe Asn Cys Leu Thr Asn Val Ser
        275                 280                 285             
Ser Phe Ser Leu Val Ser Val Thr Ile Glu Arg Val Lys Asp Phe Ser
    290                 295                 300                 
Tyr Asn Phe Gly Trp Gln His Leu Glu Leu Val Asn Cys Lys Phe Gly
305                 310                 315                 320 
Gln Phe Pro Thr Leu Lys Leu Lys Ser Leu Lys Arg Leu Thr Phe Thr
                325                 330                 335     
Ser Asn Lys Gly Gly Asn Ala Phe Ser Glu Val Asp Leu Pro Ser Leu
            340                 345                 350         
Glu Phe Leu Asp Leu Ser Arg Asn Gly Leu Ser Phe Lys Gly Cys Cys
        355                 360                 365             
Ser Gln Ser Asp Phe Gly Thr Thr Ser Leu Lys Tyr Leu Asp Leu Ser
    370                 375                 380                 
Phe Asn Gly Val Ile Thr Met Ser Ser Asn Phe Leu Gly Leu Glu Gln
385                 390                 395                 400 
Leu Glu His Leu Asp Phe Gln His Ser Asn Leu Lys Gln Met Ser Glu
                405                 410                 415     
Phe Ser Val Phe Leu Ser Leu Arg Asn Leu Ile Tyr Leu Asp Ile Ser
            420                 425                 430         
His Thr His Thr Arg Val Ala Phe Asn Gly Ile Phe Asn Gly Leu Ser
        435                 440                 445             
Ser Leu Glu Val Leu Lys Met Ala Gly Asn Ser Phe Gln Glu Asn Phe
    450                 455                 460                 
Leu Pro Asp Ile Phe Thr Glu Leu Arg Asn Leu Thr Phe Leu Asp Leu
465                 470                 475                 480 
Ser Gln Cys Gln Leu Glu Gln Leu Ser Pro Thr Ala Phe Asn Ser Leu
                485                 490                 495     
Ser Ser Leu Gln Val Leu Asn Met Ser His Asn Asn Phe Phe Ser Leu
            500                 505                 510         
Asp Thr Phe Pro Tyr Lys Cys Leu Asn Ser Leu Gln Val Leu Asp Tyr
        515                 520                 525             
Ser Leu Asn His Ile Met Thr Ser Lys Lys Gln Glu Leu Gln His Phe
    530                 535                 540                 
Pro Ser Ser Leu Ala Phe Leu Asn Leu Thr Gln Asn Asp Phe Ala Cys
545                 550                 555                 560 
Thr Cys Glu His Gln Ser Phe Leu Gln Trp Ile Lys Asp Gln Arg Gln
                565                 570                 575     
Leu Leu Val Glu Val Glu Arg Met Glu Cys Ala Thr Pro Ser Asp Lys
            580                 585                 590         
Gln Gly Met Pro Val Leu Ser Leu Asn Ile Thr Cys Gln Met Asn Lys
        595                 600                 605

<210> 42
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Toll Like Receptor 4:  transmembrane: aa 632-652

<400> 42
Thr Ile Ile Gly Val Ser Val Leu Ser Val Leu Val Val Ser Val Val
 1               5                  10                  15      
Ala Val Leu Val Tyr
            20

<210> 43
<211> 187
<212> PRT
<213> Artificial Sequence

<220> 
<223> Toll Like Receptor 4:  cytoplasmic: aa 653-839

<400> 43
Lys Phe Tyr Phe His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly
 1               5                  10                  15      
Arg Gly Glu Asn Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp
            20                  25                  30          
Glu Asp Trp Val Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val
        35                  40                  45              
Pro Pro Phe Gln Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val
    50                  55                  60                  
Ala Ile Ala Ala Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys
65                  70                  75                  80  
Val Ile Val Val Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile
                85                  90                  95      
Phe Glu Tyr Glu Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala
            100                 105                 110         
Gly Ile Ile Phe Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg
        115                 120                 125             
Gln Gln Val Glu Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu
    130                 135                 140                 
Trp Glu Asp Ser Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg
145                 150                 155                 160 
Lys Ala Leu Leu Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly
                165                 170                 175     
Thr Gly Cys Asn Trp Gln Glu Ala Thr Ser Ile
            180                 185

<210> 44
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> HRE

<400> 44
tgtcacgtcc tgcacgactc tagt                                        24

<210> 45
<211> 5820
<212> DNA
<213> Artificial Sequence

<220> 
<223> HRE-MiniTK- luciferase

<400> 45
tcgagatccg gccccgccca gcgtcttgtc attggcgaat tcgaacacgc agatgcagtc 60
ggggcggcgc ggtccgaggt ccacttcgca tattaaggtg acgcgtgtgg cctcgaacac 120
cgagcgaccc tgcagcgacc cgcttaacag cgtcaacagc gtgccgcaga tctaagtaag 180
cttggcattc cggtactgtt ggtaaaatgg aagacgccaa aaacataaag aaaggcccgg 240
cgccattcta tcctctagag gatggaaccg ctggagagca actgcataag gctatgaaga 300
gatacgccct ggttcctgga acaattgctt ttacagatgc acatatcgag gtgaacatca 360
cgtacgcgga atacttcgaa atgtccgttc ggttggcaga agctatgaaa cgatatgggc 420
tgaatacaaa tcacagaatc gtcgtatgca gtgaaaactc tcttcaattc tttatgccgg 480
tgttgggcgc gttatttatc ggagttgcag ttgcgcccgc gaacgacatt tataatgaac 540
gtgaattgct caacagtatg aacatttcgc agcctaccgt agtgtttgtt tccaaaaagg 600
ggttgcaaaa aattttgaac gtgcaaaaaa aattaccaat aatccagaaa attattatca 660
tggattctaa aacggattac cagggatttc agtcgatgta cacgttcgtc acatctcatc 720
tacctcccgg ttttaatgaa tacgattttg taccagagtc ctttgatcgt gacaaaacaa 780
ttgcactgat aatgaattcc tctggatcta ctgggttacc taagggtgtg gcccttccgc 840
atagaactgc ctgcgtcaga ttctcgcatg ccagagatcc tatttttggc aatcaaatca 900
ttccggatac tgcgatttta agtgttgttc cattccatca cggttttgga atgtttacta 960
cactcggata tttgatatgt ggatttcgag tcgtcttaat gtatagattt gaagaagagc 1020
tgtttttacg atcccttcag gattacaaaa ttcaaagtgc gttgctagta ccaaccctat 1080
tttcattctt cgccaaaagc actctgattg acaaatacga tttatctaat ttacacgaaa 1140
ttgcttctgg gggcgcacct ctttcgaaag aagtcgggga agcggttgca aaacgcttcc 1200
atcttccagg gatacgacaa ggatatgggc tcactgagac tacatcagct attctgatta 1260
cacccgaggg ggatgataaa ccgggcgcgg tcggtaaagt tgttccattt tttgaagcga 1320
aggttgtgga tctggatacc gggaaaacgc tgggcgttaa tcagagaggc gaattatgtg 1380
tcagaggacc tatgattatg tccggttatg taaacaatcc ggaagcgacc aacgccttga 1440
ttgacaagga tggatggcta cattctggag acatagctta ctgggacgaa gacgaacact 1500
tcttcatagt tgaccgcttg aagtctttaa ttaaatacaa aggatatcag gtggcccccg 1560
ctgaattgga atcgatattg ttacaacacc ccaacatctt cgacgcgggc gtggcaggtc 1620
ttcccgacga tgacgccggt gaacttcccg ccgccgttgt tgttttggag cacggaaaga 1680
cgatgacgga aaaagagatc gtggattacg tcgccagtca agtaacaacc gcgaaaaagt 1740
tgcgcggagg agttgtgttt gtggacgaag taccgaaagg tcttaccgga aaactcgacg 1800
caagaaaaat cagagagatc ctcataaagg ccaagaaggg cggaaagtcc aaattgtaaa 1860
atgtaactgt attcagcgat gacgaaattc ttagctattg taatactgcg atgagtggca 1920
gggcggggcg taattttttt aaggcagtta ttggtgccct taaacgcctg gttgctacgc 1980
ctgaataagt gataataagc ggatgaatgg cagaaattcg ccggatcttt gtgaaggaac 2040
cttacttctg tggtgtgaca taattggaca aactacctac agagatttaa agctctaagg 2100
taaatataaa atttttaagt gtataatgtg ttaaactact gattctaatt gtttgtgtat 2160
tttagattcc aacctatgga actgatgaat gggagcagtg gtggaatgcc tttaatgagg 2220
aaaacctgtt ttgctcagaa gaaatgccat ctagtgatga tgaggctact gctgactctc 2280
aacattctac tcctccaaaa aagaagagaa aggtagaaga ccccaaggac tttccttcag 2340
aattgctaag ttttttgagt catgctgtgt ttagtaatag aactcttgct tgctttgcta 2400
tttacaccac aaaggaaaaa gctgcactgc tatacaagaa aattatggaa aaatattctg 2460
taacctttat aagtaggcat aacagttata atcataacat actgtttttt cttactccac 2520
acaggcatag agtgtctgct attaataact atgctcaaaa attgtgtacc tttagctttt 2580
taatttgtaa aggggttaat aaggaatatt tgatgtatag tgccttgact agagatcata 2640
atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc 2700
ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat 2760
aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 2820
cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatccgtcga 2880
ccgatgccct tgagagcctt caacccagtc agctccttcc ggtgggcgcg gggcatgact 2940
atcgtcgccg cacttatgac tgtcttcttt atcatgcaac tcgtaggaca ggtgccggca 3000
gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc 3060
ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg 3120
aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct 3180
ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca 3240
gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct 3300
cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc 3360
gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt 3420
tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc 3480
cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc 3540
cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg 3600
gtggcctaac tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc 3660
agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag 3720
cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga 3780
tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat 3840
tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag 3900
ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat 3960
cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc 4020
cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat 4080
accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag 4140
ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg 4200
ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc 4260
tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca 4320
acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg 4380
tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc 4440
actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta 4500
ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc 4560
aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg 4620
ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc 4680
cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc 4740
aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat 4800
actcatactc ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag 4860
cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc 4920
ccgaaaagtg ccacctgacg cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt 4980
tacgcgcagc gtgaccgcta cacttgccag cgccctagcg cccgctcctt tcgctttctt 5040
cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc gggggctccc 5100
tttagggttc cgatttagtg ctttacggca cctcgacccc aaaaaacttg attagggtga 5160
tggttcacgt agtgggccat cgccctgata gacggttttt cgccctttga cgttggagtc 5220
cacgttcttt aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggt 5280
ctattctttt gatttataag ggattttgcc gatttcggcc tattggttaa aaaatgagct 5340
gatttaacaa aaatttaacg cgaattttaa caaaatatta acgcttacaa tttgccattc 5400
gccattcagg ctgcgcaact gttgggaagg gcgatcggtg cgggcctctt cgctattacg 5460
ccagcccaag ctaccatgat aagtaagtaa tattaaggta cgtggaggtt ttacttgctt 5520
taaaaaacct cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg 5580
ttaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 5640
caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 5700
cttatggtac tgtaactgag ctaacataac ccgggaggta ccgagctctg tcacgtcctg 5760
cacgactcta gttgtcacgt cctgcacgac tctagttgtc acgtcctgca cgacgctagc 5820

<210> 46
<211> 1494
<212> DNA
<213> Artificial Sequence

<220> 
<223> M-CSFR extracellular domain

<400> 46
atcccagtga tagagcccag tgtccccgag ctggtcgtga agccaggagc aacggtgacc 60
ttgcgatgtg tgggcaatgg cagcgtggaa tgggatggcc ccccatcacc tcactggacc 120
ctgtactctg atggctccag cagcatcctc agcaccaaca acgctacctt ccaaaacacg 180
gggacctatc gctgcactga gcctggagac cccctgggag gcagcgccgc catccacctc 240
tatgtcaaag accctgcccg gccctggaac gtgctagcac aggaggtggt cgtgttcgag 300
gaccaggacg cactactgcc ctgtctgctc acagacccgg tgctggaagc aggcgtctcg 360
ctggtgcgtg tgcgtggccg gcccctcatg cgccacacca actactcctt ctcgccctgg 420
catggcttca ccatccacag ggccaagttc attcagagcc aggactatca atgcagtgcc 480
ctgatgggtg gcaggaaggt gatgtccatc agcatccggc tgaaagtgca gaaagtcatc 540
ccagggcccc cagccttgac actggtgcct gcagagctgg tgcggattcg aggggaggct 600
gcccagatcg tgtgctcagc cagcagcgtt gatgttaact ttgatgtctt cctccaacac 660
aacaacacta agctcgcaat ccctcaacaa tctgactttc ataataaccg ttaccaaaaa 720
gtcctgaccc tcaacctcga tcaagtagat ttccaacatg ccggcaacta ctcctgcgtg 780
gccagcaacg tgcagggcaa gcactccacc tccatgttct tccgggtggt agagagtgcc 840
tacttgaact tgagctctga gcagaacctc atccaggagg tgaccgtggg ggaggggctc 900
aacctcaaag tcatggtgga ggcctaccca ggcctgcaag gttttaactg gacctacctg 960
ggaccctttt ctgaccacca gcctgagccc aagcttgcta atgctaccac caaggacaca 1020
tacaggcaca ccttcaccct ctctctgccc cgcctgaagc cctctgaggc tggccgctac 1080
tccttcctgg ccagaaaccc aggaggctgg agagctctga cgtttgagct cacccttcga 1140
taccccccag aggtaagcgt catatggaca ttcatcaacg gctctggcac ccttttgtgt 1200
gctgcctctg ggtaccccca gcccaacgtg acatggctgc agtgcagtgg ccacactgat 1260
aggtgtgatg aggcccaagt gctgcaggtc tgggatgacc cataccctga ggtcctgagc 1320
caggagccct tccacaaggt gacggtgcag agcctgctga ctgttgagac cttagagcac 1380
aaccaaacct acgagtgcag ggcccacaac agcgtgggga gtggctcctg ggccttcata 1440
cccatctctg caggagccca cacgcatccc ccggatgagt tcctcttcac acca       1494

<210> 47
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD28 transmembrane domain

<400> 47
gagagcaagt acggaccgcc ctgcccccct tgccct                           36

<210> 48
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> M-CSFR transmembrane domain

<400> 48
gtggtggtgg cgtgcatgag cattatggcg ctgctgctgc tgctgctgct gctgctgctg 60
tat                                                               63

<210> 49
<211> 84
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG4 hinge domain

<400> 49
atgttctggg tgctggtggt ggtcggaggc gtgctggcct gctacagcct gctggtcacc 60
gtggccttca tcatcttttg ggtg                                        84

<210> 50
<211> 561
<212> DNA
<213> Artificial Sequence

<220> 
<223> TLR4 cytoplasmic signaling domain

<400> 50
aagttctatt ttcacctgat gcttcttgct ggctgcataa agtatggtag aggtgaaaac 60
atctatgatg cctttgttat ctactcaagc caggatgagg actgggtaag gaatgagcta 120
gtaaagaatt tagaagaagg ggtgcctcca tttcagctct gccttcacta cagagacttt 180
attcccggtg tggccattgc tgccaacatc atccatgaag gtttccataa aagccgaaag 240
gtgattgttg tggtgtccca gcacttcatc cagagccgct ggtgtatctt tgaatatgag 300
attgctcaga cctggcagtt tctgagcagt cgtgctggta tcatcttcat tgtcctgcag 360
aaggtggaga agaccctgct caggcagcag gtggagctgt accgccttct cagcaggaac 420
acttacctgg agtgggagga cagtgtcctg gggcggcaca tcttctggag acgactcaga 480
aaagccctgc tggatggtaa atcatggaat ccagaaggaa cagtgggtac aggatgcaat 540
tggcaggaag caacatctat c                                           561

<210> 51
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> T2A

<400> 51
ggcggcggag agggcagagg aagtcttcta acatgcggtg acgtggagga gaatcccggc 60
cct                                                               63

<210> 52
<211> 972
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD19t marker

<400> 52
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc 60
gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag 120
gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc 180
ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc 240
tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg 300
cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag 360
ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc 420
tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc 480
aaagaccgcc ctgagatctg ggagggagag cctccgtgtg tcccaccgag ggacagcctg 540
aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt 600
ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag 660
gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg 720
gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat 780
tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta 840
tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg 900
atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg 960
aggaaaagat aa                                                     972

<210> 53
<211> 9534
<212> DNA
<213> Artificial Sequence

<220> 
<223> epHIV7.2 vector sequences with MCSFRxTLR4 chimeric
      receptor including: M-CSFR extracellular domain,
      CD28 transmembrane domain, IgG4 hinge domain, TLR4
      cytoplasmic signaling domain, T2A sequence, and
      CD19t marker

<400> 53
gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc 60
tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg 120
taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg 180
aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt 240
gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg 300
actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga 360
attagatcga tgggaaaaaa ttcggttaag gccaggggga aagaaaaaat ataaattaaa 420
acatatagta tgggcaagca gggagctaga acgattcgca gttaatcctg gcctgttaga 480
aacatcagaa ggctgtagac aaatactggg acagctacaa ccatcccttc agacaggatc 540
agaagaactt agatcattat ataatacagt agcaaccctc tattgtgtgc atcaaaggat 600
agagataaaa gacaccaagg aagctttaga caagatagag gaagagcaaa acaaaagtaa 660
gaaaaaagca cagcaagcag cagctgacac aggacacagc aatcaggtca gccaaaatta 720
ccctatagtg cagaacatcc aggggcaaat ggtacatcag gccatatcac ctagaacttt 780
aaatgcatgg gtaaaagtag tagaagagaa ggctttcagc ccagaagtga tacccatgtt 840
ttcagcatta tcagaaggag ccaccccaca agatttaaac accatgctaa acacagtggg 900
gggacatcaa gcagccatgc aaatgttaaa agagaccatc aatgaggaag ctgcaggcaa 960
agagaagagt ggtgcagaga gaaaaaagag cagtgggaat aggagctttg ttccttgggt 1020
tcttgggagc agcaggaagc actatgggcg cagcgtcaat gacgctgacg gtacaggcca 1080
gacaattatt gtctggtata gtgcagcagc agaacaattt gctgagggct attgaggcgc 1140
aacagcatct gttgcaactc acagtctggg gcatcaagca gctccaggca agaatcctgg 1200
ctgtggaaag atacctaaag gatcaacagc tcctggggat ttggggttgc tctggaaaac 1260
tcatttgcac cactgctgtg ccttggatct acaaatggca gtattcatcc acaattttaa 1320
aagaaaaggg gggattgggg ggtacagtgc aggggaaaga atagtagaca taatagcaac 1380
agacatacaa actaaagaat tacaaaaaca aattacaaaa attcaaaatt ttcgggttta 1440
ttacagggac agcagagatc cagtttgggg atcaattgca tgaagaatct gcttagggtt 1500
aggcgttttg cgctgcttcg cgaggatctg cgatcgctcc ggtgcccgtc agtgggcaga 1560
gcgcacatcg cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt gaaccggtgc 1620
ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc tccgcctttt 1680
tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg ttctttttcg 1740
caacgggttt gccgccagaa cacagctggg ctagccgcca ccatgccacc tcctcgcctc 1800
ctcttcttcc tcctcttcct cacccccatg gaagtcagga tcccagtgat agagcccagt 1860
gtccccgagc tggtcgtgaa gccaggagca acggtgacct tgcgatgtgt gggcaatggc 1920
agcgtggaat gggatggccc cccatcacct cactggaccc tgtactctga tggctccagc 1980
agcatcctca gcaccaacaa cgctaccttc caaaacacgg ggacctatcg ctgcactgag 2040
cctggagacc ccctgggagg cagcgccgcc atccacctct atgtcaaaga ccctgcccgg 2100
ccctggaacg tgctagcaca ggaggtggtc gtgttcgagg accaggacgc actactgccc 2160
tgtctgctca cagacccggt gctggaagca ggcgtctcgc tggtgcgtgt gcgtggccgg 2220
cccctcatgc gccacaccaa ctactccttc tcgccctggc atggcttcac catccacagg 2280
gccaagttca ttcagagcca ggactatcaa tgcagtgccc tgatgggtgg caggaaggtg 2340
atgtccatca gcatccggct gaaagtgcag aaagtcatcc cagggccccc agccttgaca 2400
ctggtgcctg cagagctggt gcggattcga ggggaggctg cccagatcgt gtgctcagcc 2460
agcagcgttg atgttaactt tgatgtcttc ctccaacaca acaacactaa gctcgcaatc 2520
cctcaacaat ctgactttca taataaccgt taccaaaaag tcctgaccct caacctcgat 2580
caagtagatt tccaacatgc cggcaactac tcctgcgtgg ccagcaacgt gcagggcaag 2640
cactccacct ccatgttctt ccgggtggta gagagtgcct acttgaactt gagctctgag 2700
cagaacctca tccaggaggt gaccgtgggg gaggggctca acctcaaagt catggtggag 2760
gcctacccag gcctgcaagg ttttaactgg acctacctgg gacccttttc tgaccaccag 2820
cctgagccca agcttgctaa tgctaccacc aaggacacat acaggcacac cttcaccctc 2880
tctctgcccc gcctgaagcc ctctgaggct ggccgctact ccttcctggc cagaaaccca 2940
ggaggctgga gagctctgac gtttgagctc acccttcgat accccccaga ggtaagcgtc 3000
atatggacat tcatcaacgg ctctggcacc cttttgtgtg ctgcctctgg gtacccccag 3060
cccaacgtga catggctgca gtgcagtggc cacactgata ggtgtgatga ggcccaagtg 3120
ctgcaggtct gggatgaccc ataccctgag gtcctgagcc aggagccctt ccacaaggtg 3180
acggtgcaga gcctgctgac tgttgagacc ttagagcaca accaaaccta cgagtgcagg 3240
gcccacaaca gcgtggggag tggctcctgg gccttcatac ccatctctgc aggagcccac 3300
acgcatcccc cggatgagtt cctcttcaca ccagagagca agtacggacc gccctgcccc 3360
ccttgcccta tgttctgggt gctggtggtg gtcggaggcg tgctggcctg ctacagcctg 3420
ctggtcaccg tggccttcat catcttttgg gtgaagttct attttcacct gatgcttctt 3480
gctggctgca taaagtatgg tagaggtgaa aacatctatg atgcctttgt tatctactca 3540
agccaggatg aggactgggt aaggaatgag ctagtaaaga atttagaaga aggggtgcct 3600
ccatttcagc tctgccttca ctacagagac tttattcccg gtgtggccat tgctgccaac 3660
atcatccatg aaggtttcca taaaagccga aaggtgattg ttgtggtgtc ccagcacttc 3720
atccagagcc gctggtgtat ctttgaatat gagattgctc agacctggca gtttctgagc 3780
agtcgtgctg gtatcatctt cattgtcctg cagaaggtgg agaagaccct gctcaggcag 3840
caggtggagc tgtaccgcct tctcagcagg aacacttacc tggagtggga ggacagtgtc 3900
ctggggcggc acatcttctg gagacgactc agaaaagccc tgctggatgg taaatcatgg 3960
aatccagaag gaacagtggg tacaggatgc aattggcagg aagcaacatc tatcggcggc 4020
ggagagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc cggccctatg 4080
ccacctcctc gcctcctctt cttcctcctc ttcctcaccc ccatggaagt caggcccgag 4140
gaacctctag tggtgaaggt ggaagaggga gataacgctg tgctgcagtg cctcaagggg 4200
acctcagatg gccccactca gcagctgacc tggtctcggg agtccccgct taaacccttc 4260
ttaaaactca gcctggggct gccaggcctg ggaatccaca tgaggcccct ggccatctgg 4320
cttttcatct tcaacgtctc tcaacagatg gggggcttct acctgtgcca gccggggccc 4380
ccctctgaga aggcctggca gcctggctgg acagtcaatg tggagggcag cggggagctg 4440
ttccggtgga atgtttcgga cctaggtggc ctgggctgtg gcctgaagaa caggtcctca 4500
gagggcccca gctccccttc cgggaagctc atgagcccca agctgtatgt gtgggccaaa 4560
gaccgccctg agatctggga gggagagcct ccgtgtgtcc caccgaggga cagcctgaac 4620
cagagcctca gccaggacct caccatggcc cctggctcca cactctggct gtcctgtggg 4680
gtaccccctg actctgtgtc caggggcccc ctctcctgga cccatgtgca ccccaagggg 4740
cctaagtcat tgctgagcct agagctgaag gacgatcgcc cggccagaga tatgtgggta 4800
atggagacgg gtctgttgtt gccccgggcc acagctcaag acgctggaaa gtattattgt 4860
caccgtggca acctgaccat gtcattccac ctggagatca ctgctcggcc agtactatgg 4920
cactggctgc tgaggactgg tggctggaag gtctcagctg tgactttggc ttatctgatc 4980
ttctgcctgt gttcccttgt gggcattctt catcttcaaa gagccctggt cctgaggagg 5040
aaaagataag cggccgctct agacccgggc tgcaggaatt cgatatcaag cttatcgata 5100
atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc 5160
cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta 5220
tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt 5280
ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg 5340
gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta 5400
ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt 5460
tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg 5520
cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca 5580
atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc 5640
gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcat cgataccgtc 5700
gactagccgt acctttaaga ccaatgactt acaaggcagc tgtagatctt agccactttt 5760
taaaagaaaa ggggggactg gaagggctaa ttcactccca aagaagacaa gatctgcttt 5820
ttgcctgtac tgggtctctc tggttagacc agatctgagc ctgggagctc tctggctaac 5880
tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg 5940
cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag tcagtgtgga 6000
aaatctctag cagaattcga tatcaagctt atcgataccg tcgacctcga gggggggccc 6060
ggtaccgagc tcggatccac tagtccagtg tggtggaatt ctgcagatat ccagcacagt 6120
ggcggccact caagtctgga gggcacgtta aaacccgctg atcagcctcg actgtgcctt 6180
ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg 6240
ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt 6300
gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca 6360
atagcaggca tgctggggat gcggtgggct ctatggcttc tactgggcgg ttttatggac 6420
agcaagcgaa ccggaattgc cagctggggc gccctctggt aaggttggga agccctgcaa 6480
agtaaactgg atggctttct tgccgccaag gatctgatgg cgcaggggat caagctctga 6540
tcaagagaca ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc 6600
tccggccgct tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg 6660
ctctgatgcc gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac 6720
cgacctgtcc ggtgccctga atgaactgca agacgaggca gcgcggctat cgtggctggc 6780
cacgacgggc gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg 6840
gctgctattg ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga 6900
gaaagtatcc atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg 6960
cccattcgac caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg 7020
tcttgtcgat caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt 7080
cgccaggctc aaggcgagca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc 7140
ctgcttgccg aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg 7200
gctgggtgtg gcagaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga 7260
gcttggcggc gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc 7320
gcagcgcatc gccttctatc gccttcttga cgagttcttc tgaattatta acgcttacaa 7380
tttcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatacaggt 7440
ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca 7500
aatatgtatc cgctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca 7560
gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc 7620
tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta 7680
ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgttctt 7740
ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc 7800
gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg 7860
ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg 7920
tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag 7980
ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc 8040
agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat 8100
agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg 8160
gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc 8220
tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt 8280
accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca 8340
gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg 8400
attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac 8460
gcaattaatg tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg 8520
gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc acacaggaaa cagctatgac 8580
catgattacg ccaagctcga aattaaccct cactaaaggg aacaaaagct ggagctccac 8640
cgcggtggcg gcctcgaggt cgagatccgg tcgaccagca accatagtcc cgcccctaac 8700
tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact 8760
aatttttttt atttatgcag aggccgaggc cgcctcggcc tctgagctat tccagaagta 8820
gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag cttcgacggt atcgattggc 8880
tcatgtccaa cattaccgcc atgttgacat tgattattga ctagttatta atagtaatca 8940
attacggggt cattagttca tagcccatat atggagttcc gcgttacata acttacggta 9000
aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat aatgacgtat 9060
gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga gtatttacgg 9120
taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc ccctattgac 9180
gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt atgggacttt 9240
cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat gcggttttgg 9300
cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag tctccacccc 9360
attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc aaaatgtcgt 9420
aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggaattc ggagtggcga 9480
gccctcagat cctgcatata agcagctgct ttttgcctgt actgggtctc tctg       9534

<210> 54
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> HRE from an EPO gene

<400> 54
ccgggtagct ggcgtacgtg ctgcag                                      26
