                         SEQUENCE LISTING

<110>  Juno Therapeutics, Inc.

<120>  ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR RECEPTOR 
       TYROSINE KINASE LIKE ORPHAN RECEPTOR 1 (ROR1)

<130>  735042017740

<140>  Not Yet Assigned  
<141>  Concurrently Herewith

<150>  62/798,456
<151>  2019-01-29

<160>  219   

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Spacer (IgG4 hinge)

<400>  1

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  2
<211>  36
<212>  DNA
<213>  artificial sequence

<220>
<223>  Spacer (IgG4 hinge)

<400>  2
gaatctaagt acggaccgcc ctgcccccct tgccct                                 36


<210>  3
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hinge-CH3 spacer

<400>  3

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg 
1               5                   10                  15      


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            20                  25                  30          


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        35                  40                  45              


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    50                  55                  60                  


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
65                  70                  75                  80  


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                85                  90                  95      


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Leu Gly Lys 
        115                 


<210>  4
<211>  357
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hinge-CH3 spacer

<400>  4
gaatctaagt acggaccgcc ttgtcctcca tgtcctggcc agccaagaga accccaggtg       60

tacacactgc ctccaagcca agaggaaatg accaagaacc aggtgtccct gacctgcctg      120

gtcaagggct tctacccttc cgatatcgcc gtggaatggg agagcaatgg ccagcctgag      180

aacaactaca agaccacacc tcctgtgctg gacagcgacg gctcattctt cctgtacagc      240

cggctgaccg tggacaagag cagatggcaa gagggcaacg tgttcagctg cagcgtgatg      300

cacgaggccc tgcacaacca ctacacccag aagtctctga gcctgagcct gggcaag         357


<210>  5
<211>  282
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgD-hinge-Fc

<400>  5

Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210>  6
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  T2A

<400>  6

Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
1               5                   10                  15      


Val Glu Glu Asn Pro Gly Pro Arg 
            20                  


<210>  7
<211>  357
<212>  PRT
<213>  artificial sequence

<220>
<223>  tEGFR

<400>  7

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
                325                 330                 335     


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            340                 345                 350         


Ile Gly Leu Phe Met 
        355         


<210>  8
<211>  27
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD28

<300>
<308>  P10747
<309>  1989-07-01
<313>  (153)..(179)

<400>  8

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  9
<211>  66
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD28

<300>
<308>  P10747
<309>  1989-07-01
<313>  (114)..(179)

<400>  9

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val 
65      


<210>  10
<211>  41
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD28

<300>
<308>  P10747
<309>  1989-07-01
<313>  (180)..(220)

<400>  10

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  11
<211>  41
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD28 (LL to GG)

<400>  11

Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  12
<211>  42
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  4-1BB

<300>
<308>  Q07011.1
<309>  1995-02-01
<313>  (214)..(255)

<400>  12

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  13
<211>  112
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD3 zeta

<400>  13

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  14
<211>  112
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD3 zeta

<400>  14

Arg Val Lys Phe Ser Arg Ser Ala Glu Pro Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  15
<211>  112
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD3 zeta

<400>  15

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  16
<211>  335
<212>  PRT
<213>  artificial sequence

<220>
<223>  tEGFR

<400>  16

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
                325                 330                 335 


<210>  17
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  T2A

<400>  17

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  18
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  P2A

<400>  18

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  19
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  P2A

<400>  19

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  20
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2A

<400>  20

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  21
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  F2A

<400>  21

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  22
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker


<220>
<221>  REPEAT
<222>  (5)..(9)
<223>  SGGGG is repeated 5 times

<400>  22

Pro Gly Gly Gly Ser Gly Gly Gly Gly Pro 
1               5                   10  


<210>  23
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  23

Gly Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Gly Lys 
1               5                   10                  15      


Ser 
    


<210>  24
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  24

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  25
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  hinge


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X is glycine, cysteine or arginine

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X is cysteine or threonine

<400>  25

Xaa Pro Pro Xaa Pro 
1               5   


<210>  26
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  hinge

<400>  26

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  27
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  hinge

<400>  27

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  28
<211>  61
<212>  PRT
<213>  artificial sequence

<220>
<223>  hinge

<400>  28

Glu Leu Lys Thr Pro Leu Gly Asp Thr His Thr Cys Pro Arg Cys Pro 
1               5                   10                  15      


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
            20                  25                  30          


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro 
        35                  40                  45              


Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60      


<210>  29
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  hinge

<400>  29

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  30
<211>  36
<212>  DNA
<213>  artificial sequence

<220>
<223>  Spacer (IgG4hinge) O/SSE

<400>  30
gagtctaaat acggaccgcc ttgtcctcct tgtccc                                 36


<210>  31
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  hinge

<400>  31

Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   


<210>  32
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  hinge

<400>  32

Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10  


<210>  33
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  hinge

<400>  33

Glu Val Val Val Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10                  


<210>  34
<211>  228
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hinge-CH2-CH3 spacer

<400>  34

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Leu Gly Lys 
225             


<210>  35
<211>  684
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hinge-CH2-CH3 spacer

<400>  35
gaatctaagt acggaccgcc ttgtcctcca tgtcctgctc ctccagttgc cggaccttcc       60

gtgttcctgt ttcctccaaa gcctaaggac accctgatga tcagcagaac ccctgaagtg      120

acctgcgtgg tggtggacgt gtcccaagag gatcctgagg tgcagttcaa ctggtatgtg      180

gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagtt ccagagcacc      240

tacagagtgg tgtccgtgct gacagtgctg caccaggatt ggctgaacgg caaagagtac      300

aagtgcaagg tgtccaacaa gggcctgcct agcagcatcg agaaaaccat cagcaaggcc      360

aagggccagc caagagaacc ccaggtgtac acactgcctc caagccaaga ggaaatgacc      420

aagaaccagg tgtccctgac ctgcctggtc aagggcttct acccttccga tatcgccgtg      480

gaatgggaga gcaatggcca gcctgagaac aactacaaga ccacacctcc tgtgctggac      540

agcgacggct cattcttcct gtacagccgg ctgaccgtgg acaagagcag atggcaagag      600

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag      660

tctctgagcc tgagcctggg caag                                             684


<210>  36
<211>  229
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hinge-CH2-CH3 spacer

<400>  36

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  37
<211>  228
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG4/IgG2 hinge- IgG2/IgG4 CH2- IgG4 CH3 spacer

<400>  37

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Leu Gly Lys 
225             


<210>  38
<211>  684
<212>  DNA
<213>  artificial sequence

<220>
<223>  IgG4/IgG2 hinge- IgG2/IgG4 CH2- IgG4 CH3 spacer

<400>  38
gaatctaagt acggaccgcc ctgccctccc tgccctgctc ctcctgtggc tggaccaagc       60

gtgttcctgt ttccacctaa gcctaaagat accctgatga tttcccgcac acctgaagtg      120

acttgcgtgg tcgtggacgt gagccaggag gatccagaag tgcagttcaa ctggtacgtg      180

gacggcgtgg aagtccacaa tgctaagact aaaccccgag aggaacagtt tcagtcaact      240

taccgggtcg tgagcgtgct gaccgtcctg catcaggatt ggctgaacgg gaaggagtat      300

aagtgcaaag tgtctaataa gggactgcct agctccatcg agaaaacaat tagtaaggca      360

aaagggcagc ctcgagaacc acaggtgtat accctgcccc ctagccagga ggaaatgacc      420

aagaaccagg tgtccctgac atgtctggtc aaaggcttct atccaagtga catcgccgtg      480

gagtgggaat caaatgggca gcccgagaac aattacaaga ccacaccacc cgtgctggac      540

tctgatggaa gtttctttct gtattccagg ctgaccgtgg ataaatctcg ctggcaggag      600

ggcaacgtgt tctcttgcag tgtcatgcac gaagccctgc acaatcatta tacacagaag      660

tcactgagcc tgtccctggg caaa                                             684


<210>  39
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  4GS linker

<400>  39

Gly Gly Gly Gly Ser 
1               5   


<210>  40
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  3GS linker

<400>  40

Gly Gly Gly Ser 
1               


<210>  41
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  (4GS)3 linker

<400>  41

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  42
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD33 Signal Peptide

<400>  42

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


<210>  43
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  human IgG-kappa signal peptide

<400>  43

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly 
            20  


<210>  44
<211>  60
<212>  DNA
<213>  artificial sequence

<220>
<223>  human IgG-kappa signal sequence

<400>  44
atggtgctgc agacccaggt gttcatcagc ctgctgctgt ggatctccgg agcatacgga       60


<210>  45
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  GMCSFR alpha chain signal peptide

<400>  45

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  46
<211>  66
<212>  DNA
<213>  artificial sequence

<220>
<223>  GMCSFR alpha chain signal sequence

<400>  46
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atccca                                                                  66


<210>  47
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD8 alpha signal peptide

<400>  47

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala 
        


<210>  48
<211>  326
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IgG2 Fc (Uniprot P01859)

<400>  48

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  49
<211>  327
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IgG4 Fc (Uniprot P01861)

<400>  49

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  50
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-H1

<400>  50

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  51
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-H1

<400>  51

Gly Tyr Thr Phe Thr Ser Tyr Gly Ile Ser 
1               5                   10  


<210>  52
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-H1

<400>  52

Ser Tyr Gly Ile Ser 
1               5   


<210>  53
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-H1

<400>  53

Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  54
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  54

Ser Ala Tyr Asn Gly Asn 
1               5       


<210>  55
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  55

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys 
1               5                   10  


<210>  56
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  56

Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  57
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  57

Ile Ser Ala Tyr Asn Gly Asn Thr 
1               5               


<210>  58
<211>  15
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H3

<400>  58

Asp Glu Asp Ile Leu Thr Gly Tyr Asn Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  59
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H3

<400>  59

Ala Arg Asp Glu Asp Ile Leu Thr Gly Tyr Asn Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  60
<211>  12
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-L1

<400>  60

Thr Leu Ser Ser Gly His Ser Ser Tyr Ala Ile Ala 
1               5                   10          


<210>  61
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-L1

<400>  61

Ser Gly His Ser Ser Tyr Ala 
1               5           


<210>  62
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-L2

<400>  62

Leu Asn Ser Asp Gly Ser His Ser Lys Gly Asp 
1               5                   10      


<210>  63
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-L2

<400>  63

Leu Asn Ser Asp Gly Ser His 
1               5           


<210>  64
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-L3

<400>  64

Gln Thr Trp Gly Thr Gly Ile Arg Val 
1               5                   


<210>  65
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H1

<400>  65

Gly Gly Ser Ile Ser Asn Tyr 
1               5           


<210>  66
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H1

<400>  66

Gly Gly Ser Ile Ser Asn Tyr Tyr Trp Ser 
1               5                   10  


<210>  67
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H1

<400>  67

Asn Tyr Tyr Trp Ser 
1               5   


<210>  68
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H1

<400>  68

Gly Gly Ser Ile Ser Asn Tyr Tyr 
1               5               


<210>  69
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  69

Tyr Thr Ser Gly Ser 
1               5   


<210>  70
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  70

Arg Ile Tyr Thr Ser Gly Ser Thr Asn 
1               5                   


<210>  71
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  71

Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  72
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  72

Ile Tyr Thr Ser Gly Ser Thr 
1               5           


<210>  73
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H3

<400>  73

Tyr Tyr Asp Ile Leu Thr Gly Phe Phe Asp Tyr 
1               5                   10      


<210>  74
<211>  13
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H3

<400>  74

Ala Arg Tyr Tyr Asp Ile Leu Thr Gly Phe Phe Asp Tyr 
1               5                   10              


<210>  75
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-L1

<400>  75

Arg Met Ser Gln Asp Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  76
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-L1

<400>  76

Gln Asp Ile Ser Ser Tyr 
1               5       


<210>  77
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-L2

<400>  77

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  78
<211>  3
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-L2

<400>  78

Ala Ala Ser 
1           


<210>  79
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-L3

<400>  79

Gln Gln Tyr Asp Ser Phe Pro Pro Thr 
1               5                   


<210>  80
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H1

<400>  80

Gly Gly Ser Ile Asn Ser Thr Thr Ser 
1               5                   


<210>  81
<211>  12
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H1

<400>  81

Gly Gly Ser Ile Asn Ser Thr Thr Ser Tyr Trp Ala 
1               5                   10          


<210>  82
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H1

<400>  82

Ser Thr Thr Ser Tyr Trp Ala 
1               5           


<210>  83
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H1

<400>  83

Gly Gly Ser Ile Asn Ser Thr Thr Ser Tyr 
1               5                   10  


<210>  84
<211>  4
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  84

Tyr Ser Gly Lys 
1               


<210>  85
<211>  9
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  85

Thr Ile Phe Tyr Ser Gly Lys Thr Tyr 
1               5                   


<210>  86
<211>  16
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  86

Thr Ile Phe Tyr Ser Gly Lys Thr Tyr Asn Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  87
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  87

Ile Phe Tyr Ser Gly Lys Thr 
1               5           


<210>  88
<211>  11
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H3

<400>  88

Phe Asp Tyr Gly Phe His Asp Ala Phe Asp Ile 
1               5                   10      


<210>  89
<211>  13
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H3

<400>  89

Ala Arg Phe Asp Tyr Gly Phe His Asp Ala Phe Asp Ile 
1               5                   10              


<210>  90
<211>  12
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-L1

<400>  90

Arg Ala Ser Gln Ser Ile Thr Ser Asp Tyr Leu Ser 
1               5                   10          


<210>  91
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-L1

<400>  91

Gln Ser Ile Thr Ser Asp Tyr 
1               5           


<210>  92
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-L2

<400>  92

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  93
<211>  3
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-L2

<400>  93

Gly Ala Ser 
1           


<210>  94
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-L3

<400>  94

Gln Gln Asp Tyr Asn Leu Tyr Thr 
1               5               


<210>  95
<211>  6
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  95

Ser Ala Tyr Thr Gly Asn 
1               5       


<210>  96
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  96

Trp Ile Ser Ala Tyr Thr Gly Asn Thr Arg 
1               5                   10  


<210>  97
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  97

Trp Ile Ser Ala Tyr Thr Gly Asn Thr Arg Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  98
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H2

<400>  98

Ile Ser Ala Tyr Thr Gly Asn Thr 
1               5               


<210>  99
<211>  15
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H3

<400>  99

Glu Glu Gly Ala Thr Thr Asp Tyr Asp Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  100
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDR-H3

<400>  100

Ala Arg Glu Glu Gly Ala Thr Thr Asp Tyr Asp Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  101
<211>  372
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH

<400>  101
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaagtat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagatgag      300

gatattttga ctggttacaa ctactacggt atggacgtct ggggccaagg gaccacggtc      360

accgtctcct ca                                                          372


<210>  102
<211>  372
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH O/SSE

<400>  102
caggtgcagc tggttcaatc tggcgccgaa gtgaagaaac caggcgcctc tgtgaaggtg       60

tcctgcaagg ccagcggcta cacctttacc agctacggca tcagctgggt ccgacaggct      120

cctggacaag gcttggaatg gatgggctgg atcagcgcct acaacggcaa caccaaatac      180

gcccagaaac tgcagggcag agtgaccatg accaccgaca ccagcacaag caccgcctac      240

atggaactgc ggagcctgag atccgatgac accgccgtgt actactgcgc cagagatgag      300

gacatcctga ccggctacaa ctactacggc atggacgtgt ggggccaggg cacaacagtg      360

acagtttctt ct                                                          372


<210>  103
<211>  124
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH

<400>  103

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Asp Ile Leu Thr Gly Tyr Asn Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  104
<211>  336
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL

<400>  104
cagcttgtgc tgactcaatc gccctctgcc tctgcctccc tgggagcctc ggtcaagctc       60

acctgcactc tgagcagtgg gcacagcagc tacgccatcg catggcatca gcagcagcca      120

gagaagggcc ctcggtactt gatgaagctt aacagtgatg gcagccacag caagggggac      180

gggatccctg atcgcttctc aggctccagc tctggggctg agcgctacct caccatctcc      240

agcctccagt ctgaggatga ggctgactat tactgtcaga cctggggcac tggcattcgg      300

gtgttcggtg gaggaaccaa actgactgtc ctaggc                                336


<210>  105
<211>  336
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL O/SSE

<400>  105
caactggtgc tgacacagtc tcctagcgcc tctgcttctc tgggagccag cgtgaagctg       60

acctgtacac tgtctagcgg ccacagcagc tacgccattg cttggcatca gcagcagccc      120

gagaagggcc ctagatacct gatgaagctg aacagcgacg gcagccactc taaaggcgac      180

ggcatccccg atagattcag cggcagttct agcggagccg agcgctacct gacaatcagc      240

tctctgcaat ccgaggacga ggccgactac tactgtcaga catggggcac cggcatcaga      300

gtgtttggcg gaggcaccaa gctgacagtg cttgga                                336


<210>  106
<211>  112
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL

<400>  106

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ala 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Leu Asn Ser Asp Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly 
                85                  90                  95      


Thr Gly Ile Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  107
<211>  753
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  scFv (VH-VL)

<400>  107
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acaatggtaa cacaaagtat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagatgag      300

gatattttga ctggttacaa ctactacggt atggacgtct ggggccaagg gaccacggtc      360

accgtctcct caggtggtgg tggtagcggc ggcggcggct ctggtggtgg tggatcccag      420

cttgtgctga ctcaatcgcc ctctgcctct gcctccctgg gagcctcggt caagctcacc      480

tgcactctga gcagtgggca cagcagctac gccatcgcat ggcatcagca gcagccagag      540

aagggccctc ggtacttgat gaagcttaac agtgatggca gccacagcaa gggggacggg      600

atccctgatc gcttctcagg ctccagctct ggggctgagc gctacctcac catctccagc      660

ctccagtctg aggatgaggc tgactattac tgtcagacct ggggcactgg cattcgggtg      720

ttcggtggag gaaccaaact gactgtccta ggc                                   753


<210>  108
<211>  753
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  scFv (VH-VL) O/SSE

<400>  108
caggtgcagc tggttcaatc tggcgccgaa gtgaagaaac caggcgcctc tgtgaaggtg       60

tcctgcaagg ccagcggcta cacctttacc agctacggca tcagctgggt ccgacaggct      120

cctggacaag gcttggaatg gatgggctgg atcagcgcct acaacggcaa caccaaatac      180

gcccagaaac tgcagggcag agtgaccatg accaccgaca ccagcacaag caccgcctac      240

atggaactgc ggagcctgag atccgatgac accgccgtgt actactgcgc cagagatgag      300

gacatcctga ccggctacaa ctactacggc atggacgtgt ggggccaggg cacaacagtg      360

acagtttctt ctggcggcgg aggatctggc ggaggtggaa gcggaggcgg tggatctcaa      420

ctggtgctga cacagtctcc tagcgcctct gcttctctgg gagccagcgt gaagctgacc      480

tgtacactgt ctagcggcca cagcagctac gccattgctt ggcatcagca gcagcccgag      540

aagggcccta gatacctgat gaagctgaac agcgacggca gccactctaa aggcgacggc      600

atccccgata gattcagcgg cagttctagc ggagccgagc gctacctgac aatcagctct      660

ctgcaatccg aggacgaggc cgactactac tgtcagacat ggggcaccgg catcagagtg      720

tttggcggag gcaccaagct gacagtgctt gga                                   753


<210>  109
<211>  251
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  scFv (VH-VL)

<400>  109

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Asp Ile Leu Thr Gly Tyr Asn Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala Ser Val Lys Leu Thr 
145                 150                 155                 160 


Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ala Ile Ala Trp His Gln 
                165                 170                 175     


Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met Lys Leu Asn Ser Asp 
            180                 185                 190         


Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly Thr Gly Ile Arg Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                245                 250     


<210>  110
<211>  357
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH

<400>  110
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggagg ctccatcagt aattactact ggagctggat ccggcagccc      120

gccgggaagg gactggagtg gattgggcgt atctatacca gtgggagcac caactacaac      180

ccctccctca agagtcgagt caccatgtca gtagacacgt ccaagaacca gttctccctg      240

aagctgagtt ctttgaccgc cgcggacacg gccatatatt actgtgcgag gtattacgat      300

attttgactg gtttctttga ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210>  111
<211>  357
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH O/SSE

<400>  111
caggttcagc tgcaagagtc tggccctggc ctggtcaagc ctagcgaaac actgagcctg       60

acctgtaccg tgtctggcgg cagcatctcc aactactact ggtcctggat cagacagcct      120

gccggcaaag gcctggaatg gatcggcaga atctacacca gcggcagcac caactacaac      180

cccagcctga agtccagagt gaccatgagc gtggacacca gcaagaacca gttctccctg      240

aagctgagca gcctgacagc cgccgatacc gccatctact actgtgcccg gtactacgat      300

atcctgaccg gcttcttcga ctactggggc cagggaacac tggtcacagt ttctagc         357


<210>  112
<211>  119
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH

<400>  112

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Tyr Asp Ile Leu Thr Gly Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  113
<211>  324
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL

<400>  113
gtcatctgga tgacccagtc tccatcctta ctctctgcat ctacaggaga cagtgtcacc       60

atcagttgtc ggatgagtca ggacattagc agttatttag cctggtatca gcaaaaacca      120

gggaaagccc ctgagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagac ttcactctca ccatcagttc cctgcagtct      240

gaagattttg ctacttatta ctgtcaacag tatgatagtt tccctccgac gttcggccaa      300

gggaccaagg tggaattcaa acgg                                             324


<210>  114
<211>  324
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL O/SSE

<400>  114
gtgatttgga tgacacagag ccctagcctg ctgagcgcca gcacaggcga tagcgtgacc       60

atcagctgca gaatgagcca ggacatcagc agctacctgg cttggtatca gcagaagcct      120

ggcaaggccc ctgaactgct gatctatgcc gcttccagtc tgcagagcgg cgtgccatct      180

agattttccg gcagcggctc tggcaccgac ttcaccctga caatcagctc cctgcagtcc      240

gaggacttcg ccacctacta ttgccagcag tacgacagct tccctccaac ctttggccag      300

ggcaccaagg tggaattcaa gcgc                                             324


<210>  115
<211>  108
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL

<400>  115

Val Ile Trp Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Thr Gly 
1               5                   10                  15      


Asp Ser Val Thr Ile Ser Cys Arg Met Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Phe Lys Arg 
            100                 105             


<210>  116
<211>  726
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  scFv (VH-VL)

<400>  116
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggagg ctccatcagt aattactact ggagctggat ccggcagccc      120

gccgggaagg gactggagtg gattgggcgt atctatacca gtgggagcac caactacaac      180

ccctccctca agagtcgagt caccatgtca gtagacacgt ccaagaacca gttctccctg      240

aagctgagtt ctttgaccgc cgcggacacg gccatatatt actgtgcgag gtattacgat      300

attttgactg gtttctttga ctactggggc cagggaaccc tggtcaccgt ctcctcaggt      360

ggtggtggta gcggcggcgg cggctctggt ggtggtggat ccgtcatctg gatgacccag      420

tctccatcct tactctctgc atctacagga gacagtgtca ccatcagttg tcggatgagt      480

caggacatta gcagttattt agcctggtat cagcaaaaac cagggaaagc ccctgagctc      540

ctgatctatg ctgcatccag tttgcaaagt ggggtcccat caaggttcag tggcagtgga      600

tctgggacag acttcactct caccatcagt tccctgcagt ctgaagattt tgctacttat      660

tactgtcaac agtatgatag tttccctccg acgttcggcc aagggaccaa ggtggaattc      720

aaacgg                                                                 726


<210>  117
<211>  726
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  scFv (VH-VL) O/SSE

<400>  117
caggttcagc tgcaagagtc tggccctggc ctggtcaagc ctagcgaaac actgagcctg       60

acctgtaccg tgtctggcgg cagcatctcc aactactact ggtcctggat cagacagcct      120

gccggcaaag gcctggaatg gatcggcaga atctacacca gcggcagcac caactacaac      180

cccagcctga agtccagagt gaccatgagc gtggacacca gcaagaacca gttctccctg      240

aagctgagca gcctgacagc cgccgatacc gccatctact actgtgcccg gtactacgat      300

atcctgaccg gcttcttcga ctactggggc cagggaacac tggtcacagt ttctagcgga      360

ggcggaggat ctggtggcgg aggaagtggc ggaggcggtt ctgtgatttg gatgacacag      420

agccctagcc tgctgagcgc cagcacaggc gatagcgtga ccatcagctg cagaatgagc      480

caggacatca gcagctacct ggcttggtat cagcagaagc ctggcaaggc ccctgaactg      540

ctgatctatg ccgcttccag tctgcagagc ggcgtgccat ctagattttc cggcagcggc      600

tctggcaccg acttcaccct gacaatcagc tccctgcagt ccgaggactt cgccacctac      660

tattgccagc agtacgacag cttccctcca acctttggcc agggcaccaa ggtggaattc      720

aagcgc                                                                 726


<210>  118
<211>  242
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  scFv (VH-VL)

<400>  118

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Tyr Asp Ile Leu Thr Gly Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Val Ile Trp Met Thr Gln Ser Pro Ser Leu 
    130                 135                 140                 


Leu Ser Ala Ser Thr Gly Asp Ser Val Thr Ile Ser Cys Arg Met Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Glu Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Phe Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Phe 
225                 230                 235                 240 


Lys Arg 
        


<210>  119
<211>  363
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH

<400>  119
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcaac agtactactt cctactgggc ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggactatct tttatagtgg gaaaacctac      180

aacaacccgt ccctcaagag tcgagtcacc atgtccgtag acacgtccaa gaaccacttc      240

tccctgaagg tgaactctgt gaccgccgca gacacggctg tgtattactg tgcgaggttt      300

gactacggtt ttcatgatgc ttttgatatc tggggccagg ggacaatggt caccgtctct      360

tca                                                                    363


<210>  120
<211>  363
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH O/SSE

<400>  120
cagctccagc tgcaagaatc tggacctggc ctggtcaagc ccagcgagac actgtctctg       60

acctgtacag tgtccggcgg cagcatcaat agcaccacaa gctactgggc ctggatcaga      120

cagcctcctg gcaaaggcct ggaatggatc ggcaccatct tctacagcgg caagacctac      180

aacaacccca gcctgaagtc cagagtgacc atgagcgtgg acaccagcaa gaaccacttc      240

agcctgaaag tgaacagcgt gacagccgcc gataccgccg tgtactactg cgccagattc      300

gactacggct tccacgacgc cttcgacatc tggggccagg gcacaatggt cacagtttct      360

agc                                                                    363


<210>  121
<211>  121
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH

<400>  121

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Ser Thr 
            20                  25                  30          


Thr Ser Tyr Trp Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Thr Ile Phe Tyr Ser Gly Lys Thr Tyr Asn Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn His Phe 
65                  70                  75                  80  


Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Phe Asp Tyr Gly Phe His Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  122
<211>  324
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL

<400>  122
gaaattgtaa tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtattacc agcgactact tatcctggta ccaacaaaaa      120

cctgggcagg ctcccaggct cctcatctat ggtgcatcca ccagggccac tggcatccca      180

gccaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagcctgcag      240

cctgaagatt ttgtagttta ttactgtcag caggattata acttgtacac ttttggccag      300

gggaccaagc tggagatcaa acgg                                             324


<210>  123
<211>  324
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL O/SSE

<400>  123
gagattgtga tgacacagag ccccgccact ctgagcctta gtcctggcga aagagccaca       60

ctgagctgca gagccagcca gagcatcacc agcgattacc tgagctggta tcagcagaag      120

cccggacagg ctcccagact gctgatctat ggcgcctcta caagagccac cggcattccc      180

gcccgctttt ctggctctgg aagcggcacc gacttcaccc tgaccatatc tagcctgcag      240

cctgaggact tcgtggtgta ctattgccag caggactaca acctgtacac cttcggccag      300

gggaccaagc tggaaatcaa gaga                                             324


<210>  124
<211>  108
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VL

<400>  124

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Val Val Tyr Tyr Cys Gln Gln Asp Tyr Asn Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  125
<211>  732
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  scFv (VH-VL)

<400>  125
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcaac agtactactt cctactgggc ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggactatct tttatagtgg gaaaacctac      180

aacaacccgt ccctcaagag tcgagtcacc atgtccgtag acacgtccaa gaaccacttc      240

tccctgaagg tgaactctgt gaccgccgca gacacggctg tgtattactg tgcgaggttt      300

gactacggtt ttcatgatgc ttttgatatc tggggccagg ggacaatggt caccgtctct      360

tcaggtggtg gtggtagcgg cggcggcggc tctggtggtg gtggatccga aattgtaatg      420

acacagtctc cagccaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg      480

gccagtcaga gtattaccag cgactactta tcctggtacc aacaaaaacc tgggcaggct      540

cccaggctcc tcatctatgg tgcatccacc agggccactg gcatcccagc caggttcagt      600

ggcagtgggt ctgggacaga cttcactctc accatcagca gcctgcagcc tgaagatttt      660

gtagtttatt actgtcagca ggattataac ttgtacactt ttggccaggg gaccaagctg      720

gagatcaaac gg                                                          732


<210>  126
<211>  732
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  scFv (VH-VL) O/SSE

<400>  126
cagctccagc tgcaagaatc tggacctggc ctggtcaagc ccagcgagac actgtctctg       60

acctgtacag tgtccggcgg cagcatcaat agcaccacaa gctactgggc ctggatcaga      120

cagcctcctg gcaaaggcct ggaatggatc ggcaccatct tctacagcgg caagacctac      180

aacaacccca gcctgaagtc cagagtgacc atgagcgtgg acaccagcaa gaaccacttc      240

agcctgaaag tgaacagcgt gacagccgcc gataccgccg tgtactactg cgccagattc      300

gactacggct tccacgacgc cttcgacatc tggggccagg gcacaatggt cacagtttct      360

agcggaggcg gaggatctgg tggcggagga agtggcggag gcggttctga gattgtgatg      420

acacagagcc ccgccactct gagccttagt cctggcgaaa gagccacact gagctgcaga      480

gccagccaga gcatcaccag cgattacctg agctggtatc agcagaagcc cggacaggct      540

cccagactgc tgatctatgg cgcctctaca agagccaccg gcattcccgc ccgcttttct      600

ggctctggaa gcggcaccga cttcaccctg accatatcta gcctgcagcc tgaggacttc      660

gtggtgtact attgccagca ggactacaac ctgtacacct tcggccaggg gaccaagctg      720

gaaatcaaga ga                                                          732


<210>  127
<211>  244
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  scFv (VH-VL)

<400>  127

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Ser Thr 
            20                  25                  30          


Thr Ser Tyr Trp Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Thr Ile Phe Tyr Ser Gly Lys Thr Tyr Asn Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn His Phe 
65                  70                  75                  80  


Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Phe Asp Tyr Gly Phe His Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Thr Ser Asp Tyr Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala 
            180                 185                 190         


Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Val Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Asp Tyr Asn Leu Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Arg 
                


<210>  128
<211>  372
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH

<400>  128
caggttcagc tgctgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acactggtaa cacaaggtat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagaagaa      300

ggagctacta cggactacga ctactacggt atggacgtct ggggccaagg gactgcggtc      360

accgtctcct ca                                                          372


<210>  129
<211>  372
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH O/SSE

<400>  129
caggttcagc tgcttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg ccagcggcta cacctttacc agctacggca tcagctgggt ccgacaggct      120

cctggacaag gcttggaatg gatgggctgg atcagcgcct acaccggcaa taccagatac      180

gcccagaaac tgcagggcag agtgaccatg accaccgaca ccagcacaag caccgcctac      240

atggaactgc ggagcctgag atccgatgac accgccgtgt actactgcgc cagagaagaa      300

ggcgccacca ccgactacga ctactacggc atggatgtgt ggggccaggg aacagccgtg      360

acagtttctt ct                                                          372


<210>  130
<211>  124
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  VH

<400>  130

Gln Val Gln Leu Leu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Thr Gly Asn Thr Arg Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Gly Ala Thr Thr Asp Tyr Asp Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
        115                 120                 


<210>  131
<211>  336
<212>  DNA
<213>  artificial sequence

<220>
<223>  VL O/SSE

<400>  131
caactggttc tgacacagag cccaagcgcc tctgcatctc tgggagcttc cgtgaagctg       60

acctgcacac tgtctagcgg ccacagcagc tatgccattg cctggcatca gcaacagccc      120

gagaagggcc ctagatacct gatgaagctg aacagcgacg gcagccactc taaaggcgac      180

ggcatccccg atagattcag cggcagttct agcggagccg agcgctacct gacaatcagc      240

tctctgcaat ccgaggacga ggccgattac tactgtcaga catggggcac cggcatcaga      300

gtgtttggcg gcggaacaaa gctgaccgtg ctgggc                                336


<210>  132
<211>  696
<212>  DNA
<213>  artificial sequence

<220>
<223>  scFv (VH-VL)

<400>  132
caggttcagc tgctgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acactggtaa cacaaggtat      180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgag cacagcctac      240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagaagaa      300

ggagctacta cggactacga ctactacggt atggacgtct ggggccaagg gactgcggtc      360

accgtctcct caggtggtgg tggtagcggc ggcggcggct ctggtggtgg tggatcccag      420

cttgtgctga ctcaatcgcc ctctgcctct gcctccctgg gagcctcggt caagctcacc      480

tgcactctga gcagtgggca cagcagctac gccatcgcat ggcatcagca gcagccagag      540

aagggccctc ggtacttgat gaagcttaac agtgatggca gccacagcaa gggggacggg      600

atccctgatc gcttctcagg ctccagctct ggggctgagc gctacctcac catctccagc      660

ctccagtctg aggatgaggc tgactattac tgtcag                                696


<210>  133
<211>  753
<212>  DNA
<213>  artificial sequence

<220>
<223>  scFv (VH-VL) O/SSE

<400>  133
caggttcagc tgcttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg ccagcggcta cacctttacc agctacggca tcagctgggt ccgacaggct      120

cctggacaag gcttggaatg gatgggctgg atcagcgcct acaccggcaa taccagatac      180

gcccagaaac tgcagggcag agtgaccatg accaccgaca ccagcacaag caccgcctac      240

atggaactgc ggagcctgag atccgatgac accgccgtgt actactgcgc cagagaagaa      300

ggcgccacca ccgactacga ctactacggc atggatgtgt ggggccaggg aacagccgtg      360

acagtttctt ctggtggcgg aggatctggc ggaggtggaa gcggcggagg cggatctcaa      420

ctggttctga cacagagccc aagcgcctct gcatctctgg gagcttccgt gaagctgacc      480

tgcacactgt ctagcggcca cagcagctat gccattgcct ggcatcagca acagcccgag      540

aagggcccta gatacctgat gaagctgaac agcgacggca gccactctaa aggcgacggc      600

atccccgata gattcagcgg cagttctagc ggagccgagc gctacctgac aatcagctct      660

ctgcaatccg aggacgaggc cgattactac tgtcagacat ggggcaccgg catcagagtg      720

tttggcggcg gaacaaagct gaccgtgctg ggc                                   753


<210>  134
<211>  251
<212>  PRT
<213>  artificial sequence

<220>
<223>  scFv (VH-VL)

<400>  134

Gln Val Gln Leu Leu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Thr Gly Asn Thr Arg Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Gly Ala Thr Thr Asp Tyr Asp Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala Ser Val Lys Leu Thr 
145                 150                 155                 160 


Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ala Ile Ala Trp His Gln 
                165                 170                 175     


Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met Lys Leu Asn Ser Asp 
            180                 185                 190         


Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly Thr Gly Ile Arg Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
                245                 250     


<210>  135
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG4 hinge spacer

<400>  135

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Met 
1               5                   10              


<210>  136
<211>  39
<212>  DNA
<213>  artificial sequence

<220>
<223>  IgG4 hinge spacer O/SSE

<400>  136
gagtctaaat acggaccgcc ttgtcctcct tgtcccatg                              39


<210>  137
<211>  357
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hinge-CH3 spacer O/SSE

<400>  137
gagtctaaat acggaccgcc ttgtcctcct tgtcccggcc agccaagaga gccccaggtt       60

tacacactgc ctccaagcca agaggaaatg accaagaatc aggtgtccct gacatgcctg      120

gtcaagggct tctacccctc cgatatcgcc gtggaatggg agagcaatgg ccagcctgag      180

aacaactaca agaccacacc tcctgtgctg gacagcgacg gcagtttctt cctgtatagt      240

agactcaccg tggataaatc aagatggcaa gagggcaacg tgttcagctg cagcgtgatg      300

cacgaggccc tgcacaacca ctacacccag aaaagcctga gcctgtctct gggcaag         357


<210>  138
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Hinge-CH3 spacer

<400>  138

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg 
1               5                   10                  15      


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            20                  25                  30          


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        35                  40                  45              


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    50                  55                  60                  


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
65                  70                  75                  80  


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                85                  90                  95      


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Leu Gly Lys Met 
        115                 120 


<210>  139
<211>  360
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hinge-CH3 spacer O/SSE

<400>  139
gagtctaaat acggaccgcc ttgtcctcct tgtcccggcc agccaagaga gccccaggtt       60

tacacactgc ctccaagcca agaggaaatg accaagaatc aggtgtccct gacatgcctg      120

gtcaagggct tctacccctc cgatatcgcc gtggaatggg agagcaatgg ccagcctgag      180

aacaactaca agaccacacc tcctgtgctg gacagcgacg gcagtttctt cctgtatagt      240

agactcaccg tggataaatc aagatggcaa gagggcaacg tgttcagctg cagcgtgatg      300

cacgaggccc tgcacaacca ctacacccag aaaagcctga gcctgtctct gggcaagatg      360


<210>  140
<211>  684
<212>  DNA
<213>  artificial sequence

<220>
<223>  IgG4/IgG2 hinge- IgG2/IgG4 CH2- IgG4 CH3 spacer O/SSE

<400>  140
gagtctaaat acggaccgcc ttgtcctcct tgtcccgctc ctcctgttgc cggaccttcc       60

gtgttcctgt ttcctccaaa gcctaaggac accctgatga tcagcaggac ccctgaagtg      120

acctgcgtgg tggtggatgt gtcccaagag gatcccgagg tgcagttcaa ctggtatgtg      180

gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagtt ccagagcacc      240

tacagagtgg tgtccgtgct gacagtgctg caccaggatt ggctgaacgg caaagagtac      300

aagtgcaagg tgtccaacaa gggcctgcct agcagcatcg agaaaaccat ctccaaggcc      360

aagggccagc caagagagcc ccaggtttac acactgcctc caagccaaga ggaaatgacc      420

aagaatcagg tgtccctgac atgcctggtc aagggcttct acccctccga tatcgccgtg      480

gaatgggaga gcaatggcca gcctgagaac aactacaaga ccacacctcc tgtgctggac      540

agcgacggca gtttcttcct gtatagtaga ctcaccgtgg ataaatcaag atggcaagag      600

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaaa      660

agcctgagcc tgtctctggg caag                                             684


<210>  141
<211>  72
<212>  DNA
<213>  artificial sequence

<220>
<223>  T2A O/SSE

<400>  141
cttgaaggtg gtggcgaagg cagaggcagc ctgcttacat gcggagatgt ggaagagaac       60

cccggaccta ga                                                           72


<210>  142
<211>  248
<212>  PRT
<213>  artificial sequence

<220>
<223>  R12 VH-VL scFv

<400>  142

Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Val Ser Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 


Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln 
                165                 170                 175     


Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         


Thr Lys Arg Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             


Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Gln Leu Thr Val Thr Gly 
                245             


<210>  143
<211>  745
<212>  DNA
<213>  artificial sequence

<220>
<223>  R12 VH-VL scFv

<400>  143
caagaacagc tggtggaatc tggcggcaga ctggttacac ctggcggaag cctgacactg       60

agctgtaaag ccagcggctt cgacttcagc gcctactaca tgagctgggt ccgacaggcc      120

cctggcaaag gactggaatg gatcgccaca atctacccca gctccggcaa gacctactac      180

gccacatggg tcaacggccg gttcaccatc agcagcgaca acgcccagaa caccgtggac      240

ctgcagatga actctctgac agccgccgac cgggccacct acttttgtgc cagagatagc      300

tacgccgacg acggcgccct gttcaatatt tggggacctg gcacactcgt gaccatctct      360

agcggaggcg gaggaagtgg tggcggagga tcaggcggtg gtggatctga actggtgctg      420

acacagagcc cctctgtgtc tgctgctctg ggaagccctg ccaagatcac atgtaccctg      480

agcagcgccc acaagaccga caccatcgac tggtatcagc agctgcaggg cgaagcccct      540

agatacctga tgcaggttca gagcgacggc agctacacca aaagacctgg cgtgcccgat      600

agattcagcg gcagttcttc tggcgccgat cgctacctga tcatcccttc tgtgcaagcc      660

gacgatgagg ccgactatta ctgcggagcc gattacatcg gcggctacgt tttcggtggc      720

ggcacacagt tgacagtgac aggcg                                            745


<210>  144
<211>  908
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human ROR1 GenBank: AAA60275.1

<400>  144

Gln Glu Thr Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser 
1               5                   10                  15      


Trp Asn Ile Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp 
            20                  25                  30          


Glu Pro Met Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu 
        35                  40                  45              


His Cys Lys Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys 
    50                  55                  60                  


Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser 
65                  70                  75                  80  


Thr Ile Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp 
                85                  90                  95      


Thr Gly Tyr Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser 
            100                 105                 110         


Ser Thr Gly Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser 
        115                 120                 125             


Pro Gly Tyr Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr 
    130                 135                 140                 


Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met 
145                 150                 155                 160 


Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala 
                165                 170                 175     


Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln 
            180                 185                 190         


Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu 
        195                 200                 205             


Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu 
    210                 215                 220                 


Ile Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser 
225                 230                 235                 240 


Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu 
                245                 250                 255     


Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile 
            260                 265                 270         


Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr 
        275                 280                 285             


Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln 
    290                 295                 300                 


Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala 
305                 310                 315                 320 


Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro 
                325                 330                 335     


Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe 
            340                 345                 350         


Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys 
        355                 360                 365             


Glu Lys Asn Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala 
    370                 375                 380                 


Ile Pro Leu Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg 
385                 390                 395                 400 


Asn Asn Gln Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His 
                405                 410                 415     


Val Arg Gly Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro 
            420                 425                 430         


Lys Ser Lys Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu 
        435                 440                 445             


Glu Leu Gly Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr 
    450                 455                 460                 


Leu Pro Gly Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys 
465                 470                 475                 480 


Asp Tyr Asn Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser 
                485                 490                 495     


Leu Met Ala Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala 
            500                 505                 510         


Val Thr Gln Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln 
        515                 520                 525             


Gly Asp Leu His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val 
    530                 535                 540                 


Gly Cys Ser Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His 
545                 550                 555                 560 


Gly Asp Phe Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr 
                565                 570                 575     


Leu Ser Ser His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile 
            580                 585                 590         


Leu Ile Gly Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser 
        595                 600                 605             


Arg Glu Ile Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu 
    610                 615                 620                 


Leu Pro Ile Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe 
625                 630                 635                 640 


Ser Ser Asp Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile 
                645                 650                 655     


Phe Ser Phe Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val 
            660                 665                 670         


Ile Glu Met Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys 
        675                 680                 685             


Pro Pro Arg Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro 
    690                 695                 700                 


Ser Arg Arg Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp 
705                 710                 715                 720 


Glu Gly Leu Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn 
                725                 730                 735     


Ala Thr Thr Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu 
            740                 745                 750         


Ser Asn Pro Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr 
        755                 760                 765             


Pro Gln Gly Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn 
    770                 775                 780                 


Gln Arg Phe Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala 
785                 790                 795                 800 


Ala Phe Pro Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile 
                805                 810                 815     


Gln His Cys Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly 
            820                 825                 830         


Ser Thr Ser Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn 
        835                 840                 845             


Gln Glu Ala Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His 
    850                 855                 860                 


Pro Gly Gly Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro 
865                 870                 875                 880 


Tyr Lys Ile Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile 
                885                 890                 895     


His Gly His Thr Glu Ser Met Ile Ser Ala Glu Leu 
            900                 905             


<210>  145
<211>  520
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human ROR1 isoform 2

<400>  145

Gln Glu Thr Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser 
1               5                   10                  15      


Trp Asn Ile Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp 
            20                  25                  30          


Glu Pro Met Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu 
        35                  40                  45              


His Cys Lys Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys 
    50                  55                  60                  


Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser 
65                  70                  75                  80  


Thr Ile Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp 
                85                  90                  95      


Thr Gly Tyr Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser 
            100                 105                 110         


Ser Thr Gly Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser 
        115                 120                 125             


Pro Gly Tyr Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr 
    130                 135                 140                 


Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met 
145                 150                 155                 160 


Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala 
                165                 170                 175     


Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln 
            180                 185                 190         


Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu 
        195                 200                 205             


Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu 
    210                 215                 220                 


Ile Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser 
225                 230                 235                 240 


Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu 
                245                 250                 255     


Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile 
            260                 265                 270         


Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr 
        275                 280                 285             


Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln 
    290                 295                 300                 


Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala 
305                 310                 315                 320 


Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro 
                325                 330                 335     


Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe 
            340                 345                 350         


Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys 
        355                 360                 365             


Glu Lys Asn Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala 
    370                 375                 380                 


Ile Pro Leu Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg 
385                 390                 395                 400 


Asn Asn Gln Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His 
                405                 410                 415     


Val Arg Gly Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro 
            420                 425                 430         


Lys Ser Lys Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu 
        435                 440                 445             


Glu Leu Gly Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr 
    450                 455                 460                 


Leu Pro Gly Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys 
465                 470                 475                 480 


Asp Tyr Asn Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser 
                485                 490                 495     


Leu Met Ala Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala 
            500                 505                 510         


Val Thr Gln Glu Gln Pro Val Cys 
        515                 520 


<210>  146
<211>  364
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human ROR1 isoform 3

<400>  146

Gln Glu Thr Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser 
1               5                   10                  15      


Trp Asn Ile Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp 
            20                  25                  30          


Glu Pro Met Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu 
        35                  40                  45              


His Cys Lys Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys 
    50                  55                  60                  


Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser 
65                  70                  75                  80  


Thr Ile Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp 
                85                  90                  95      


Thr Gly Tyr Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser 
            100                 105                 110         


Ser Thr Gly Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser 
        115                 120                 125             


Pro Gly Tyr Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr 
    130                 135                 140                 


Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met 
145                 150                 155                 160 


Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala 
                165                 170                 175     


Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln 
            180                 185                 190         


Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu 
        195                 200                 205             


Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu 
    210                 215                 220                 


Ile Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser 
225                 230                 235                 240 


Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu 
                245                 250                 255     


Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile 
            260                 265                 270         


Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr 
        275                 280                 285             


Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln 
    290                 295                 300                 


Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala 
305                 310                 315                 320 


Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro 
                325                 330                 335     


Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe 
            340                 345                 350         


Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Gly Lys 
        355                 360                 


<210>  147
<211>  84
<212>  DNA
<213>  artificial sequence

<220>
<223>  CD28 transmembrane domain

<400>  147
atgttttggg tgctggtcgt ggtcggaggg gtgctggcct gttacagcct gctggtgaca       60

gtcgctttca tcatcttctg ggtg                                              84


<210>  148
<211>  84
<212>  DNA
<213>  artificial sequence

<220>
<223>  CD28 transmembrane domain (O/SSE)

<400>  148
atgttctggg tgctcgtggt cgttggcgga gtgctggcct gttacagcct gctggttacc       60

gtggccttca tcatcttttg ggtc                                              84


<210>  149
<211>  28
<212>  PRT
<213>  artificial sequence

<220>
<223>  CD28 transmembrane domain

<400>  149

Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25              


<210>  150
<211>  336
<212>  DNA
<213>  artificial sequence

<220>
<223>  CD3-zeta derived intracellular signaling domain (O/SSE)

<400>  150
agagtgaagt tcagcagatc cgccgacgct ccagcctatc agcagggcca aaaccagctg       60

tacaacgagc tgaacctggg gagaagagaa gagtacgacg tgctggataa gcggagaggc      120

agagatcctg aaatgggcgg caagcccaga cggaagaatc ctcaagaggg cctgtataat      180

gagctgcaga aagacaagat ggccgaggcc tacagcgaga tcggaatgaa gggcgagcgc      240

agaagaggca agggacacga tggactgtac cagggcctga gcaccgccac caaggatacc      300

tatgacgcac tgcacatgca ggccctgcca cctaga                                336


<210>  151
<211>  1074
<212>  DNA
<213>  artificial sequence

<220>
<223>  truncated EGFR (tEGFR) sequence

<400>  151
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccacgca aagtgtgtaa cggaataggt attggtgaat ttaaagactc actctccata      120

aatgctacga atattaaaca cttcaaaaac tgcacctcca tcagtggcga tctccacatc      180

ctgccggtgg catttagggg tgactccttc acacatactc ctcctctgga tccacaggaa      240

ctggatattc tgaaaaccgt aaaggaaatc acagggtttt tgctgattca ggcttggcct      300

gaaaacagga cggacctcca tgcctttgag aacctagaaa tcatacgcgg caggaccaag      360

caacatggtc agttttctct tgcagtcgtc agcctgaaca taacatcctt gggattacgc      420

tccctcaagg agataagtga tggagatgtg ataatttcag gaaacaaaaa tttgtgctat      480

gcaaatacaa taaactggaa aaaactgttt gggacctccg gtcagaaaac caaaattata      540

agcaacagag gtgaaaacag ctgcaaggcc acaggccagg tctgccatgc cttgtgctcc      600

cccgagggct gctggggccc ggagcccagg gactgcgtct cttgccggaa tgtcagccga      660

ggcagggaat gcgtggacaa gtgcaacctt ctggagggtg agccaaggga gtttgtggag      720

aactctgagt gcatacagtg ccacccagag tgcctgcctc aggccatgaa catcacctgc      780

acaggacggg gaccagacaa ctgtatccag tgtgcccact acattgacgg cccccactgc      840

gtcaagacct gcccggcagg agtcatggga gaaaacaaca ccctggtctg gaagtacgca      900

gacgccggcc atgtgtgcca cctgtgccat ccaaactgca cctacggatg cactgggcca      960

ggtcttgaag gctgtccaac gaatgggcct aagatcccgt ccatcgccac tgggatggtg     1020

ggggccctcc tcttgctgct ggtggtggcc ctggggatcg gcctcttcat gtga           1074


<210>  152
<211>  1074
<212>  DNA
<213>  artificial sequence

<220>
<223>  truncated EGFR (tEGFR) sequence (O/SSE)

<400>  152
atgctgctcc tcgtgacaag cctgctcctg tgtgaactcc ctcatccagc ttttctgctc       60

attcctcgga aagtgtgcaa cggcatcggc atcggagagt tcaaggacag cctgagcatc      120

aatgccacca acatcaagca cttcaagaat tgcaccagca tcagcggcga cctgcacatt      180

ctgcctgtgg cctttagagg cgacagcttc acccacacac ctccactgga tccccaagag      240

ctggatatcc tgaaaaccgt gaaagagatt accggattcc tcctgatcca agcctggcca      300

gagaacagaa ccgatctgca cgccttcgag aacctcgaga tcatcagagg ccggaccaaa      360

cagcacggcc agtttagcct ggctgtggtg tctctgaaca tcaccagtct gggcctgaga      420

agcctgaaag aaatctccga cggcgacgtg atcatctccg gaaacaagaa cctgtgctac      480

gccaacacca tcaactggaa gaagctgttc ggcacctccg gccagaaaac aaagatcatc      540

tctaaccggg gcgagaacag ctgcaaggcc accggacaag tttgtcacgc cctgtgtagc      600

cctgaaggct gttggggacc cgaacctaga gactgtgtgt cctgccggaa tgtgtcccgg      660

ggcagagaat gtgtggataa gtgcaacctg ctggaaggcg agccccgcga gtttgtggaa      720

aacagcgagt gcatccagtg tcaccccgag tgtctgcccc aggccatgaa cattacatgc      780

accggcagag gccccgacaa ctgtattcag tgcgcccact acatcgacgg ccctcactgc      840

gtgaaaacat gtccagctgg cgtgatggga gagaacaaca ccctcgtgtg gaagtatgcc      900

gacgccggac atgtgtgcca cctgtgtcac cctaattgca cctacggctg taccggacct      960

ggcctggaag gatgccctac aaacggccct aagatcccca gcattgccac cggaatggtt     1020

ggagccctgc tgcttctgtt ggtggtggcc ctcggaatcg gcctgttcat gtga           1074


<210>  153
<211>  357
<212>  PRT
<213>  artificial sequence

<220>
<223>  truncated EGFR (tEGFR) sequence

<400>  153

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
                325                 330                 335     


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            340                 345                 350         


Ile Gly Leu Phe Met 
        355         


<210>  154
<211>  126
<212>  DNA
<213>  artificial sequence

<220>
<223>  4-1BB intracellular co-signaling sequence

<400>  154
aagcggggga gaaagaaact gctgtatatt ttcaaacagc cctttatgag acctgtgcag       60

actacccagg aggaagacgg atgcagctgt aggtttcccg aggaagagga aggaggctgt      120

gagctg                                                                 126


<210>  155
<211>  126
<212>  DNA
<213>  artificial sequence

<220>
<223>  4-1BB intracellular co-signaling sequence (O/SSE)

<400>  155
aagcggggca gaaagaagct gctctacatc ttcaagcagc ccttcatgcg gcccgtgcag       60

accacacaag aggaagatgg ctgctcctgc agattccccg aggaagaaga aggcggctgc      120

gagctg                                                                 126


<210>  156
<211>  1308
<212>  DNA
<213>  artificial sequence

<220>
<223>  anti-ROR1 CAR

<400>  156
caggttcagc tgcaagagtc tggccctggc ctggtcaagc ctagcgaaac actgagcctg       60

acctgtaccg tgtctggcgg cagcatctcc aactactact ggtcctggat cagacagcct      120

gccggcaaag gcctggaatg gatcggcaga atctacacca gcggcagcac caactacaac      180

cccagcctga agtccagagt gaccatgagc gtggacacca gcaagaacca gttctccctg      240

aagctgagca gcctgacagc cgccgatacc gccatctact actgtgcccg gtactacgat      300

atcctgaccg gcttcttcga ctactggggc cagggaacac tggtcacagt ttctagcgga      360

ggcggaggat ctggtggcgg aggaagtggc ggaggcggtt ctgtgatttg gatgacacag      420

agccctagcc tgctgagcgc cagcacaggc gatagcgtga ccatcagctg cagaatgagc      480

caggacatca gcagctacct ggcttggtat cagcagaagc ctggcaaggc ccctgaactg      540

ctgatctatg ccgcttccag tctgcagagc ggcgtgccat ctagattttc cggcagcggc      600

tctggcaccg acttcaccct gacaatcagc tccctgcagt ccgaggactt cgccacctac      660

tattgccagc agtacgacag cttccctcca acctttggcc agggcaccaa ggtggaattc      720

aagcgcgagt ctaaatacgg accgccttgt cctccttgtc ccatgttctg ggtgctcgtg      780

gtcgttggcg gagtgctggc ctgttacagc ctgctggtta ccgtggcctt catcatcttt      840

tgggtcaagc ggggcagaaa gaagctgctc tacatcttca agcagccctt catgcggccc      900

gtgcagacca cacaagagga agatggctgc tcctgcagat tccccgagga agaagaaggc      960

ggctgcgagc tgagagtgaa gttcagcaga tccgccgacg ctccagccta tcagcagggc     1020

caaaaccagc tgtacaacga gctgaacctg gggagaagag aagagtacga cgtgctggat     1080

aagcggagag gcagagatcc tgaaatgggc ggcaagccca gacggaagaa tcctcaagag     1140

ggcctgtata atgagctgca gaaagacaag atggccgagg cctacagcga gatcggaatg     1200

aagggcgagc gcagaagagg caagggacac gatggactgt accagggcct gagcaccgcc     1260

accaaggata cctatgacgc actgcacatg caggccctgc cacctaga                  1308


<210>  157
<211>  1314
<212>  DNA
<213>  artificial sequence

<220>
<223>  anti-ROR1 CAR

<400>  157
cagctccagc tgcaagaatc tggacctggc ctggtcaagc ccagcgagac actgtctctg       60

acctgtacag tgtccggcgg cagcatcaat agcaccacaa gctactgggc ctggatcaga      120

cagcctcctg gcaaaggcct ggaatggatc ggcaccatct tctacagcgg caagacctac      180

aacaacccca gcctgaagtc cagagtgacc atgagcgtgg acaccagcaa gaaccacttc      240

agcctgaaag tgaacagcgt gacagccgcc gataccgccg tgtactactg cgccagattc      300

gactacggct tccacgacgc cttcgacatc tggggccagg gcacaatggt cacagtttct      360

agcggaggcg gaggatctgg tggcggagga agtggcggag gcggttctga gattgtgatg      420

acacagagcc ccgccactct gagccttagt cctggcgaaa gagccacact gagctgcaga      480

gccagccaga gcatcaccag cgattacctg agctggtatc agcagaagcc cggacaggct      540

cccagactgc tgatctatgg cgcctctaca agagccaccg gcattcccgc ccgcttttct      600

ggctctggaa gcggcaccga cttcaccctg accatatcta gcctgcagcc tgaggacttc      660

gtggtgtact attgccagca ggactacaac ctgtacacct tcggccaggg gaccaagctg      720

gaaatcaaga gagagtctaa atacggaccg ccttgtcctc cttgtcccat gttctgggtg      780

ctcgtggtcg ttggcggagt gctggcctgt tacagcctgc tggttaccgt ggccttcatc      840

atcttttggg tcaagcgggg cagaaagaag ctgctctaca tcttcaagca gcccttcatg      900

cggcccgtgc agaccacaca agaggaagat ggctgctcct gcagattccc cgaggaagaa      960

gaaggcggct gcgagctgag agtgaagttc agcagatccg ccgacgctcc agcctatcag     1020

cagggccaaa accagctgta caacgagctg aacctgggga gaagagaaga gtacgacgtg     1080

ctggataagc ggagaggcag agatcctgaa atgggcggca agcccagacg gaagaatcct     1140

caagagggcc tgtataatga gctgcagaaa gacaagatgg ccgaggccta cagcgagatc     1200

ggaatgaagg gcgagcgcag aagaggcaag ggacacgatg gactgtacca gggcctgagc     1260

accgccacca aggataccta tgacgcactg cacatgcagg ccctgccacc taga           1314


<210>  158
<211>  1629
<212>  DNA
<213>  artificial sequence

<220>
<223>  anti-ROR1 CAR

<400>  158
caggttcagc tgcaagagtc tggccctggc ctggtcaagc ctagcgaaac actgagcctg       60

acctgtaccg tgtctggcgg cagcatctcc aactactact ggtcctggat cagacagcct      120

gccggcaaag gcctggaatg gatcggcaga atctacacca gcggcagcac caactacaac      180

cccagcctga agtccagagt gaccatgagc gtggacacca gcaagaacca gttctccctg      240

aagctgagca gcctgacagc cgccgatacc gccatctact actgtgcccg gtactacgat      300

atcctgaccg gcttcttcga ctactggggc cagggaacac tggtcacagt ttctagcgga      360

ggcggaggat ctggtggcgg aggaagtggc ggaggcggtt ctgtgatttg gatgacacag      420

agccctagcc tgctgagcgc cagcacaggc gatagcgtga ccatcagctg cagaatgagc      480

caggacatca gcagctacct ggcttggtat cagcagaagc ctggcaaggc ccctgaactg      540

ctgatctatg ccgcttccag tctgcagagc ggcgtgccat ctagattttc cggcagcggc      600

tctggcaccg acttcaccct gacaatcagc tccctgcagt ccgaggactt cgccacctac      660

tattgccagc agtacgacag cttccctcca acctttggcc agggcaccaa ggtggaattc      720

aagcgcgagt ctaaatacgg accgccttgt cctccttgtc ccggccagcc aagagagccc      780

caggtttaca cactgcctcc aagccaagag gaaatgacca agaatcaggt gtccctgaca      840

tgcctggtca agggcttcta cccctccgat atcgccgtgg aatgggagag caatggccag      900

cctgagaaca actacaagac cacacctcct gtgctggaca gcgacggcag tttcttcctg      960

tatagtagac tcaccgtgga taaatcaaga tggcaagagg gcaacgtgtt cagctgcagc     1020

gtgatgcacg aggccctgca caaccactac acccagaaaa gcctgagcct gtctctgggc     1080

aagatgttct gggtgctcgt ggtcgttggc ggagtgctgg cctgttacag cctgctggtt     1140

accgtggcct tcatcatctt ttgggtcaag cggggcagaa agaagctgct ctacatcttc     1200

aagcagccct tcatgcggcc cgtgcagacc acacaagagg aagatggctg ctcctgcaga     1260

ttccccgagg aagaagaagg cggctgcgag ctgagagtga agttcagcag atccgccgac     1320

gctccagcct atcagcaggg ccaaaaccag ctgtacaacg agctgaacct ggggagaaga     1380

gaagagtacg acgtgctgga taagcggaga ggcagagatc ctgaaatggg cggcaagccc     1440

agacggaaga atcctcaaga gggcctgtat aatgagctgc agaaagacaa gatggccgag     1500

gcctacagcg agatcggaat gaagggcgag cgcagaagag gcaagggaca cgatggactg     1560

taccagggcc tgagcaccgc caccaaggat acctatgacg cactgcacat gcaggccctg     1620

ccacctaga                                                             1629


<210>  159
<211>  1656
<212>  DNA
<213>  artificial sequence

<220>
<223>  anti-ROR1 CAR

<400>  159
caggtgcagc tggttcaatc tggcgccgaa gtgaagaaac caggcgcctc tgtgaaggtg       60

tcctgcaagg ccagcggcta cacctttacc agctacggca tcagctgggt ccgacaggct      120

cctggacaag gcttggaatg gatgggctgg atcagcgcct acaacggcaa caccaaatac      180

gcccagaaac tgcagggcag agtgaccatg accaccgaca ccagcacaag caccgcctac      240

atggaactgc ggagcctgag atccgatgac accgccgtgt actactgcgc cagagatgag      300

gacatcctga ccggctacaa ctactacggc atggacgtgt ggggccaggg cacaacagtg      360

acagtttctt ctggcggcgg aggatctggc ggaggtggaa gcggaggcgg tggatctcaa      420

ctggtgctga cacagtctcc tagcgcctct gcttctctgg gagccagcgt gaagctgacc      480

tgtacactgt ctagcggcca cagcagctac gccattgctt ggcatcagca gcagcccgag      540

aagggcccta gatacctgat gaagctgaac agcgacggca gccactctaa aggcgacggc      600

atccccgata gattcagcgg cagttctagc ggagccgagc gctacctgac aatcagctct      660

ctgcaatccg aggacgaggc cgactactac tgtcagacat ggggcaccgg catcagagtg      720

tttggcggag gcaccaagct gacagtgctt ggagagtcta aatacggacc gccttgtcct      780

ccttgtcccg gccagccaag agagccccag gtttacacac tgcctccaag ccaagaggaa      840

atgaccaaga atcaggtgtc cctgacatgc ctggtcaagg gcttctaccc ctccgatatc      900

gccgtggaat gggagagcaa tggccagcct gagaacaact acaagaccac acctcctgtg      960

ctggacagcg acggcagttt cttcctgtat agtagactca ccgtggataa atcaagatgg     1020

caagagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1080

cagaaaagcc tgagcctgtc tctgggcaag atgttctggg tgctcgtggt cgttggcgga     1140

gtgctggcct gttacagcct gctggttacc gtggccttca tcatcttttg ggtcaagcgg     1200

ggcagaaaga agctgctcta catcttcaag cagcccttca tgcggcccgt gcagaccaca     1260

caagaggaag atggctgctc ctgcagattc cccgaggaag aagaaggcgg ctgcgagctg     1320

agagtgaagt tcagcagatc cgccgacgct ccagcctatc agcagggcca aaaccagctg     1380

tacaacgagc tgaacctggg gagaagagaa gagtacgacg tgctggataa gcggagaggc     1440

agagatcctg aaatgggcgg caagcccaga cggaagaatc ctcaagaggg cctgtataat     1500

gagctgcaga aagacaagat ggccgaggcc tacagcgaga tcggaatgaa gggcgagcgc     1560

agaagaggca agggacacga tggactgtac cagggcctga gcaccgccac caaggatacc     1620

tatgacgcac tgcacatgca ggccctgcca cctaga                               1656


<210>  160
<211>  1635
<212>  DNA
<213>  artificial sequence

<220>
<223>  anti-ROR1 CAR

<400>  160
cagctccagc tgcaagaatc tggacctggc ctggtcaagc ccagcgagac actgtctctg       60

acctgtacag tgtccggcgg cagcatcaat agcaccacaa gctactgggc ctggatcaga      120

cagcctcctg gcaaaggcct ggaatggatc ggcaccatct tctacagcgg caagacctac      180

aacaacccca gcctgaagtc cagagtgacc atgagcgtgg acaccagcaa gaaccacttc      240

agcctgaaag tgaacagcgt gacagccgcc gataccgccg tgtactactg cgccagattc      300

gactacggct tccacgacgc cttcgacatc tggggccagg gcacaatggt cacagtttct      360

agcggaggcg gaggatctgg tggcggagga agtggcggag gcggttctga gattgtgatg      420

acacagagcc ccgccactct gagccttagt cctggcgaaa gagccacact gagctgcaga      480

gccagccaga gcatcaccag cgattacctg agctggtatc agcagaagcc cggacaggct      540

cccagactgc tgatctatgg cgcctctaca agagccaccg gcattcccgc ccgcttttct      600

ggctctggaa gcggcaccga cttcaccctg accatatcta gcctgcagcc tgaggacttc      660

gtggtgtact attgccagca ggactacaac ctgtacacct tcggccaggg gaccaagctg      720

gaaatcaaga gagagtctaa atacggaccg ccttgtcctc cttgtcccgg ccagccaaga      780

gagccccagg tttacacact gcctccaagc caagaggaaa tgaccaagaa tcaggtgtcc      840

ctgacatgcc tggtcaaggg cttctacccc tccgatatcg ccgtggaatg ggagagcaat      900

ggccagcctg agaacaacta caagaccaca cctcctgtgc tggacagcga cggcagtttc      960

ttcctgtata gtagactcac cgtggataaa tcaagatggc aagagggcaa cgtgttcagc     1020

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaaaagcct gagcctgtct     1080

ctgggcaaga tgttctgggt gctcgtggtc gttggcggag tgctggcctg ttacagcctg     1140

ctggttaccg tggccttcat catcttttgg gtcaagcggg gcagaaagaa gctgctctac     1200

atcttcaagc agcccttcat gcggcccgtg cagaccacac aagaggaaga tggctgctcc     1260

tgcagattcc ccgaggaaga agaaggcggc tgcgagctga gagtgaagtt cagcagatcc     1320

gccgacgctc cagcctatca gcagggccaa aaccagctgt acaacgagct gaacctgggg     1380

agaagagaag agtacgacgt gctggataag cggagaggca gagatcctga aatgggcggc     1440

aagcccagac ggaagaatcc tcaagagggc ctgtataatg agctgcagaa agacaagatg     1500

gccgaggcct acagcgagat cggaatgaag ggcgagcgca gaagaggcaa gggacacgat     1560

ggactgtacc agggcctgag caccgccacc aaggatacct atgacgcact gcacatgcag     1620

gccctgccac ctaga                                                      1635


<210>  161
<211>  1656
<212>  DNA
<213>  anti-ROR1 CAR

<400>  161
caggttcagc tgcttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg ccagcggcta cacctttacc agctacggca tcagctgggt ccgacaggct      120

cctggacaag gcttggaatg gatgggctgg atcagcgcct acaccggcaa taccagatac      180

gcccagaaac tgcagggcag agtgaccatg accaccgaca ccagcacaag caccgcctac      240

atggaactgc ggagcctgag atccgatgac accgccgtgt actactgcgc cagagaagaa      300

ggcgccacca ccgactacga ctactacggc atggatgtgt ggggccaggg aacagccgtg      360

acagtttctt ctggtggcgg aggatctggc ggaggtggaa gcggcggagg cggatctcaa      420

ctggttctga cacagagccc aagcgcctct gcatctctgg gagcttccgt gaagctgacc      480

tgcacactgt ctagcggcca cagcagctat gccattgcct ggcatcagca acagcccgag      540

aagggcccta gatacctgat gaagctgaac agcgacggca gccactctaa aggcgacggc      600

atccccgata gattcagcgg cagttctagc ggagccgagc gctacctgac aatcagctct      660

ctgcaatccg aggacgaggc cgattactac tgtcagacat ggggcaccgg catcagagtg      720

tttggcggcg gaacaaagct gaccgtgctg ggcgagtcta aatacggacc gccttgtcct      780

ccttgtcccg gccagccaag agagccccag gtttacacac tgcctccaag ccaagaggaa      840

atgaccaaga atcaggtgtc cctgacatgc ctggtcaagg gcttctaccc ctccgatatc      900

gccgtggaat gggagagcaa tggccagcct gagaacaact acaagaccac acctcctgtg      960

ctggacagcg acggcagttt cttcctgtat agtagactca ccgtggataa atcaagatgg     1020

caagagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1080

cagaaaagcc tgagcctgtc tctgggcaag atgttctggg tgctcgtggt cgttggcgga     1140

gtgctggcct gttacagcct gctggttacc gtggccttca tcatcttttg ggtcaagcgg     1200

ggcagaaaga agctgctcta catcttcaag cagcccttca tgcggcccgt gcagaccaca     1260

caagaggaag atggctgctc ctgcagattc cccgaggaag aagaaggcgg ctgcgagctg     1320

agagtgaagt tcagcagatc cgccgacgct ccagcctatc agcagggcca aaaccagctg     1380

tacaacgagc tgaacctggg gagaagagaa gagtacgacg tgctggataa gcggagaggc     1440

agagatcctg aaatgggcgg caagcccaga cggaagaatc ctcaagaggg cctgtataat     1500

gagctgcaga aagacaagat ggccgaggcc tacagcgaga tcggaatgaa gggcgagcgc     1560

agaagaggca agggacacga tggactgtac cagggcctga gcaccgccac caaggatacc     1620

tatgacgcac tgcacatgca ggccctgcca cctaga                               1656


<210>  162
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  162

Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Leu Glu Met Ala 
            20      


<210>  163
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  163

Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Leu Glu Met Ala 
            20          


<210>  164
<211>  544
<212>  DNA
<213>  artificial sequence

<220>
<223>  EF1alpha promoter with HTLV1 ehancer

<400>  164
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctac                                                                   544


<210>  165
<211>  588
<212>  DNA
<213>  artificial sequence

<220>
<223>  Woodchuck Hepatitis Virus (WHP) Posttranscriptional Regulatory 
       Element (WPRE)

<400>  165
atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc       60

cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta      120

tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt      180

ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg      240

gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta      300

ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt      360

tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg      420

cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca      480

atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc      540

gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgc                   588


<210>  166
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  T2A peptide

<400>  166

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  167
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  E2A peptide

<400>  167

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  168
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  F2A peptide

<400>  168

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  169
<211>  72
<212>  DNA
<213>  artificial sequence

<220>
<223>  T2A peptide

<400>  169
ctcgagggcg gcggagaggg cagaggaagt cttctaacat gcggtgacgt ggaggagaat       60

cccggcccta gg                                                           72


<210>  170
<211>  3358
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  human ROR1 GenBank: M97675.1

<400>  170
gagctggagc agccgccacc gccgccgccg agggagcccc gggacggcag cccctgggcg       60

cagggtgcgc tgttctcgga gtccgaccca gggcgactca cgcccactgg tgcgacccgg      120

acagcctggg actgacccgc cggcccaggc gaggctgcag ccagagggct gggaagggat      180

cgcgctcgcg gcatccagag gcggccaggc ggaggcgagg gagcaggtta gagggacaaa      240

gagctttgca gacgtccccg gcgtcctgcg agcgccagcg gccgggacga ggcggccggg      300

agcccgggaa gagcccgtgg atgttctgcg cgcggcctgg gagccgccgc cgccgccgcc      360

tcagcgagag gaggaatgca ccggccgcgc cgccgcggga cgcgcccgcc gctcctggcg      420

ctgctggccg cgctgctgct ggccgcacgc ggggctgctg cccaagaaac agagctgtca      480

gtcagtgctg aattagtgcc tacctcatca tggaacatct caagtgaact caacaaagat      540

tcttacctga cccttgatga accaatgaat aacatcacca cgtctctggg ccagacagca      600

gaactgcact gcaaagtctc tgggaatcca cctcccacca tccgctggtt caaaaatgat      660

gctcctgtgg tccaggagcc ccggaggctc tcctttcggt ccaccatcta tggctctcgg      720

ctgcggatta gaaacctcga caccacagac acaggctact tccagtgcgt ggcaacaaac      780

ggcaaggagg tggtttcttc cactggagtc ttgtttgtca agtttggccc ccctcccact      840

gcaagtccag gatactcaga tgagtatgaa gaagatggat tctgtcagcc atacagaggg      900

attgcatgtg caagatttat tggcaaccgc accgtctata tggagtcttt gcacatgcaa      960

ggggaaatag aaaatcagat cacagctgcc ttcactatga ttggcacttc cagtcactta     1020

tctgataagt gttctcagtt cgccattcct tccctgtgcc actatgcctt cccgtactgc     1080

gatgaaactt catccgtccc aaagccccgt gacttgtgtc gcgatgaatg tgaaatcctg     1140

gagaatgtcc tgtgtcaaac agagtacatt tttgcaagat caaatcccat gattctgatg     1200

aggctgaaac tgccaaactg tgaagatctc ccccagccag agagcccaga agctgcgaac     1260

tgtatccgga ttggaattcc catggcagat cctataaata aaaatcacaa gtgttataac     1320

agcacaggtg tggactaccg ggggaccgtc agtgtgacca aatcagggcg ccagtgccag     1380

ccatggaatt cccagtatcc ccacacacac actttcaccg cccttcgttt cccagagctg     1440

aatggaggcc attcctactg ccgcaaccca gggaatcaaa aggaagctcc ctggtgcttc     1500

accttggatg aaaactttaa gtctgatctg tgtgacatcc cagcttgcga ttcaaaggat     1560

tccaaggaga agaataaaat ggaaatcctg tacatactag tgccaagtgt ggccattccc     1620

ctggccattg ctttactctt cttcttcatt tgcgtctgtc ggaataacca gaagtcatcg     1680

tcggcaccag tccagaggca accaaaacac gtcagaggtc aaaatgtgga gatgtcaatg     1740

ctgaatgcat ataaacccaa gagcaaggct aaagagctac ctctttctgc tgtacgcttt     1800

atggaagaat tgggtgagtg tgcctttgga aaaatctata aaggccatct ctatctccca     1860

ggcatggacc atgctcagct ggttgctatc aagaccttga aagactataa caacccccag     1920

caatggatgg aatttcaaca agaagcctcc ctaatggcag aactgcacca ccccaatatt     1980

gtctgccttc taggtgccgt cactcaggaa caacctgtgt gcatgctttt tgagtatatt     2040

aatcaggggg atctccatga gttcctcatc atgagatccc cacactctga tgttggctgc     2100

agcagtgatg aagatgggac tgtgaaatcc agcctggacc acggagattt tctgcacatt     2160

gcaattcaga ttgcagctgg catggaatac ctgtctagtc acttctttgt ccacaaggac     2220

cttgcagctc gcaatatttt aatcggagag caacttcatg taaagatttc agacttgggg     2280

ctttccagag aaatttactc cgctgattac tacagggtcc agagtaagtc cttgctgccc     2340

attcgctgga tgccccctga agccatcatg tatggcaaat tctcttctga ttcagatatc     2400

tggtcctttg gggttgtctt gtgggagatt ttcagttttg gactccagcc atattatgga     2460

ttcagtaacc aggaagtgat tgagatggtg agaaaacggc agctcttacc atgctctgaa     2520

gactgcccac ccagaatgta cagcctcatg acagagtgct ggaatgagat tccttctagg     2580

agaccaagat ttaaagatat tcacgtccgg cttcggtcct gggagggact ctcaagtcac     2640

acaagctcta ctactccttc agggggaaat gccaccacac agacaacctc cctcagtgcc     2700

agcccagtga gtaatctcag taaccccaga tatcctaatt acatgttccc gagccagggt     2760

attacaccac agggccagat tgctggtttc attggcccgc caatacctca gaaccagcga     2820

ttcattccca tcaatggata cccaatacct cctggatatg cagcgtttcc agctgcccac     2880

taccagccaa caggtcctcc cagagtgatt cagcactgcc cacctcccaa gagtcggtcc     2940

ccaagcagtg ccagtgggtc gactagcact ggccatgtga ctagcttgcc ctcatcagga     3000

tccaatcagg aagcaaatat tcctttacta ccacacatgt caattccaaa tcatcctggt     3060

ggaatgggta tcaccgtttt tggcaacaaa tctcaaaaac cctacaaaat tgactcaaag     3120

caagcatctt tactaggaga cgccaatatt catggacaca ccgaatctat gatttctgca     3180

gaactgtaaa atgcacaact tttgtaaatg tggtatacag gacaaactag acggccgtag     3240

aaaagattta tattcaaatg tttttattaa agtaaggttc tcatttagca gacatcgcaa     3300

caagtacctt ctgtgaagtt tcactgtgtc ttaccaagca ggacagacac tcggccag       3358


<210>  171
<211>  908
<212>  PRT
<213>  mus musculus


<220>
<221>  MISC_FEATURE
<223>  Mouse ROR1; GenBank No. NP_038873

<400>  171

Gln Glu Thr Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser 
1               5                   10                  15      


Trp Asn Thr Ser Ser Glu Ile Asp Lys Gly Ser Tyr Leu Thr Leu Asp 
            20                  25                  30          


Glu Pro Met Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu 
        35                  40                  45              


His Cys Lys Val Ser Gly Asn Pro Pro Pro Ser Ile Arg Trp Phe Lys 
    50                  55                  60                  


Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ser Phe Arg Ala 
65                  70                  75                  80  


Thr Asn Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp 
                85                  90                  95      


Thr Gly Tyr Phe Gln Cys Val Ala Thr Asn Gly Lys Lys Val Val Ser 
            100                 105                 110         


Thr Thr Gly Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser 
        115                 120                 125             


Pro Gly Ser Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr 
    130                 135                 140                 


Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met 
145                 150                 155                 160 


Glu Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala 
                165                 170                 175     


Phe Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln 
            180                 185                 190         


Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu 
        195                 200                 205             


Thr Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu 
    210                 215                 220                 


Val Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser 
225                 230                 235                 240 


Asn Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu 
                245                 250                 255     


Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile 
            260                 265                 270         


Pro Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr 
        275                 280                 285             


Gly Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln 
    290                 295                 300                 


Cys Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Ser Phe Thr Ala 
305                 310                 315                 320 


Leu Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro 
                325                 330                 335     


Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe 
            340                 345                 350         


Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys 
        355                 360                 365             


Glu Lys Asn Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala 
    370                 375                 380                 


Ile Pro Leu Ala Ile Ala Phe Leu Phe Phe Phe Ile Cys Val Cys Arg 
385                 390                 395                 400 


Asn Asn Gln Lys Ser Ser Ser Pro Pro Val Gln Arg Gln Pro Lys Pro 
                405                 410                 415     


Val Arg Gly Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro 
            420                 425                 430         


Lys Ser Lys Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu 
        435                 440                 445             


Glu Leu Gly Glu Cys Thr Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr 
    450                 455                 460                 


Leu Pro Gly Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys 
465                 470                 475                 480 


Asp Tyr Asn Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser 
                485                 490                 495     


Leu Met Ala Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala 
            500                 505                 510         


Val Thr Gln Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Met Asn Gln 
        515                 520                 525             


Gly Asp Leu His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val 
    530                 535                 540                 


Gly Cys Ser Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His 
545                 550                 555                 560 


Gly Asp Phe Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr 
                565                 570                 575     


Leu Ser Ser His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile 
            580                 585                 590         


Leu Ile Gly Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser 
        595                 600                 605             


Arg Glu Ile Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Ser 
    610                 615                 620                 


Leu Pro Ile Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe 
625                 630                 635                 640 


Ser Ser Asp Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile 
                645                 650                 655     


Phe Ser Phe Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val 
            660                 665                 670         


Ile Glu Met Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys 
        675                 680                 685             


Pro Pro Arg Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro 
    690                 695                 700                 


Ser Arg Arg Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp 
705                 710                 715                 720 


Glu Gly Leu Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn 
                725                 730                 735     


Ala Thr Thr Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu 
            740                 745                 750         


Ser Asn Pro Arg Phe Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr 
        755                 760                 765             


Pro Gln Gly Gln Ile Ala Gly Phe Ile Gly Pro Ala Ile Pro Gln Asn 
    770                 775                 780                 


Gln Arg Phe Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala 
785                 790                 795                 800 


Ala Phe Pro Ala Ala His Tyr Gln Pro Ala Gly Pro Pro Arg Val Ile 
                805                 810                 815     


Gln His Cys Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly 
            820                 825                 830         


Ser Thr Ser Thr Gly His Val Ala Ser Leu Pro Ser Ser Gly Ser Asn 
        835                 840                 845             


Gln Glu Ala Asn Val Pro Leu Leu Pro His Met Ser Ile Pro Asn His 
    850                 855                 860                 


Pro Gly Gly Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro 
865                 870                 875                 880 


Tyr Lys Ile Asp Ser Lys Gln Ser Ser Leu Leu Gly Asp Ser His Ile 
                885                 890                 895     


His Gly His Thr Glu Ser Met Ile Ser Ala Glu Val 
            900                 905             


<210>  172
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  2A2 VH

<400>  172

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Ile Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Gly Tyr Tyr Asp Tyr Asp Ser Phe Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  173
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  2A2 VL

<400>  173

Asp Ile Val Met Thr Gln Ser Gln Lys Ile Met Ser Thr Thr Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Ala Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asp Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  174
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  99961 humanized VH

<400>  174

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ala Phe Thr Ala Tyr 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Phe Asp Pro Tyr Asp Gly Gly Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Tyr Tyr Phe Asp Tyr Trp Gly His Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  175
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  99961 humanized VH

<400>  175

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ala Phe Thr Ala Tyr 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Phe Asp Pro Tyr Asp Gly Gly Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Tyr Tyr Phe Asp Tyr Trp Gly His Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  176
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  99961 humanized VH

<400>  176

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ala Phe Thr Ala Tyr 
            20                  25                  30          


Asn Ile His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Phe Asp Pro Tyr Asp Gly Gly Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Tyr Tyr Phe Asp Tyr Trp Gly His Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  177
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  99961 humanized VH

<400>  177

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ala Phe Thr Ala Tyr 
            20                  25                  30          


Asn Ile His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Phe Asp Pro Tyr Asp Gly Gly Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val 
65                  70                  75                  80  


Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Tyr Tyr Phe Asp Tyr Trp Gly His Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  178
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  99961 humanized VL

<400>  178

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys Gln Gln His Asp Glu Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Glu Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  179
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  99961 humanized VL

<400>  179

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys Gln Gln His Asp Glu Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Glu Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  180
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  99961 humanized VL

<400>  180

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys Gln Gln His Asp Glu Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Glu Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  181
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  99961 humanized VL

<400>  181

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Ile Glu Ser 
65                  70                  75                  80  


Glu Asp Ala Ala Tyr Tyr Phe Cys Gln Gln His Asp Glu Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Glu Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  182
<211>  336
<212>  DNA
<213>  artificial sequence

<220>
<223>  CD3-zeta derived intracellular signaling domain

<400>  182
agagtcaagt tttccaggtc cgccgacgct ccagcctacc agcaggggca gaaccagctg       60

tacaacgagc tgaacctggg cagaagggaa gagtacgacg tcctggataa gcggagaggc      120

cgggaccctg agatgggcgg caagcctcgg cggaagaacc cccaggaagg cctgtataac      180

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg      240

aggcggggca agggccacga cggcctgtat cagggcctgt ccaccgccac caaggatacc      300

tacgacgccc tgcacatgca ggccctgccc ccaagg                                336


<210>  183
<211>  123
<212>  DNA
<213>  artificial sequence

<220>
<223>  CD28 endodomain

<400>  183
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  184
<211>  436
<212>  PRT
<213>  artificial sequence

<220>
<223>  anti-ROR1 CAR

<400>  184

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Tyr Asp Ile Leu Thr Gly Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Val Ile Trp Met Thr Gln Ser Pro Ser Leu 
    130                 135                 140                 


Leu Ser Ala Ser Thr Gly Asp Ser Val Thr Ile Ser Cys Arg Met Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Glu Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Phe Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Phe 
225                 230                 235                 240 


Lys Arg Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Met Phe 
                245                 250                 255     


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
            260                 265                 270         


Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys 
        275                 280                 285             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    290                 295                 300                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
305                 310                 315                 320 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                325                 330                 335     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            340                 345                 350         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        355                 360                 365             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
385                 390                 395                 400 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                405                 410                 415     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            420                 425                 430         


Leu Pro Pro Arg 
        435     


<210>  185
<211>  438
<212>  PRT
<213>  artificial sequence

<220>
<223>  anti-ROR1 CAR

<400>  185

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Ser Thr 
            20                  25                  30          


Thr Ser Tyr Trp Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Thr Ile Phe Tyr Ser Gly Lys Thr Tyr Asn Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn His Phe 
65                  70                  75                  80  


Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Phe Asp Tyr Gly Phe His Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Thr Ser Asp Tyr Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala 
            180                 185                 190         


Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Val Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Asp Tyr Asn Leu Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Arg Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
                245                 250                 255     


Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
            260                 265                 270         


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
        275                 280                 285             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    290                 295                 300                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
305                 310                 315                 320 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                325                 330                 335     


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            340                 345                 350         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        355                 360                 365             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    370                 375                 380                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
385                 390                 395                 400 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                405                 410                 415     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            420                 425                 430         


Gln Ala Leu Pro Pro Arg 
        435             


<210>  186
<211>  543
<212>  PRT
<213>  artificial sequence

<220>
<223>  anti-ROR1 CAR

<400>  186

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Leu Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Tyr Asp Ile Leu Thr Gly Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Val Ile Trp Met Thr Gln Ser Pro Ser Leu 
    130                 135                 140                 


Leu Ser Ala Ser Thr Gly Asp Ser Val Thr Ile Ser Cys Arg Met Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Glu Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Ser Phe Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Phe 
225                 230                 235                 240 


Lys Arg Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln 
                245                 250                 255     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            260                 265                 270         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        275                 280                 285             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
305                 310                 315                 320 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                325                 330                 335     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            340                 345                 350         


Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu Val Val 
        355                 360                 365             


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    370                 375                 380                 


Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
385                 390                 395                 400 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                405                 410                 415     


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            420                 425                 430         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        435                 440                 445             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    450                 455                 460                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
465                 470                 475                 480 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                485                 490                 495     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            500                 505                 510         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        515                 520                 525             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 540             


<210>  187
<211>  552
<212>  PRT
<213>  artificial sequence

<220>
<223>  anti-ROR1 CAR

<400>  187

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Lys Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Asp Ile Leu Thr Gly Tyr Asn Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala Ser Val Lys Leu Thr 
145                 150                 155                 160 


Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ala Ile Ala Trp His Gln 
                165                 170                 175     


Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met Lys Leu Asn Ser Asp 
            180                 185                 190         


Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly Thr Gly Ile Arg Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Glu Ser Lys Tyr Gly 
                245                 250                 255     


Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            260                 265                 270         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        275                 280                 285             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    290                 295                 300                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
305                 310                 315                 320 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                325                 330                 335     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            340                 345                 350         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        355                 360                 365             


Gly Lys Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    370                 375                 380                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
385                 390                 395                 400 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
                405                 410                 415     


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
            420                 425                 430         


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
        435                 440                 445             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    450                 455                 460                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
465                 470                 475                 480 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                485                 490                 495     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            500                 505                 510         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        515                 520                 525             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    530                 535                 540                 


His Met Gln Ala Leu Pro Pro Arg 
545                 550         


<210>  188
<211>  545
<212>  PRT
<213>  artificial sequence

<220>
<223>  anti-ROR1 CAR

<400>  188

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Ser Thr 
            20                  25                  30          


Thr Ser Tyr Trp Ala Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Thr Ile Phe Tyr Ser Gly Lys Thr Tyr Asn Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn His Phe 
65                  70                  75                  80  


Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Phe Asp Tyr Gly Phe His Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Thr Ser Asp Tyr Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala 
            180                 185                 190         


Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Val Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Asp Tyr Asn Leu Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys Arg Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
                245                 250                 255     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            260                 265                 270         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        275                 280                 285             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    290                 295                 300                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
305                 310                 315                 320 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                325                 330                 335     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            340                 345                 350         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met Phe Trp Val Leu 
        355                 360                 365             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    370                 375                 380                 


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
385                 390                 395                 400 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                405                 410                 415     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            420                 425                 430         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        435                 440                 445             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    450                 455                 460                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
465                 470                 475                 480 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                485                 490                 495     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            500                 505                 510         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        515                 520                 525             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    530                 535                 540                 


Arg 
545 


<210>  189
<211>  552
<212>  PRT
<213>  artificial sequence

<220>
<223>  anti-ROR1 CAR

<400>  189

Gln Val Gln Leu Leu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Thr Gly Asn Thr Arg Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Gly Ala Thr Thr Asp Tyr Asp Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala Ser Val Lys Leu Thr 
145                 150                 155                 160 


Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ala Ile Ala Trp His Gln 
                165                 170                 175     


Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met Lys Leu Asn Ser Asp 
            180                 185                 190         


Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly Thr Gly Ile Arg Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Glu Ser Lys Tyr Gly 
                245                 250                 255     


Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            260                 265                 270         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        275                 280                 285             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    290                 295                 300                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
305                 310                 315                 320 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                325                 330                 335     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            340                 345                 350         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        355                 360                 365             


Gly Lys Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    370                 375                 380                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
385                 390                 395                 400 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
                405                 410                 415     


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
            420                 425                 430         


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
        435                 440                 445             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    450                 455                 460                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
465                 470                 475                 480 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                485                 490                 495     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            500                 505                 510         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        515                 520                 525             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    530                 535                 540                 


His Met Gln Ala Leu Pro Pro Arg 
545                 550         


<210>  190
<211>  48
<212>  DNA
<213>  artificial sequence

<220>
<223>  CD33 signal sequence (O/SSE)

<400>  190
atgcctctgc tgctgcttct gcctcttctt tgggctggtg ctctggct                    48


<210>  191
<211>  48
<212>  DNA
<213>  artificial sequence

<220>
<223>  CD33 signal sequence GenBank: M23197.1

<400>  191
atgccgctgc tgctactgct gcccctgctg tgggcagggg ccctggct                    48


<210>  192
<211>  39
<212>  DNA
<213>  artificial sequence

<220>
<223>  Spacer (IgG4 hinge)

<400>  192
gaatctaagt acggaccgcc ctgcccccct tgccctatg                              39


<210>  193
<211>  357
<212>  DNA
<213>  artificial sequence

<220>
<223>  Hinge-CH3 spacer

<400>  193
gaatctaagt acggaccgcc ttgtcctcca tgtcctggcc agccaagaga accccaggtg       60

tacacactgc ctccaagcca agaggaaatg accaagaacc aggtgtccct gacctgcctg      120

gtcaagggct tctacccttc cgatatcgcc gtggaatggg agagcaatgg ccagcctgag      180

aacaactaca agaccacacc tcctgtgctg gacagcgacg gctcattctt cctgtacagc      240

cggctgaccg tggacaagag cagatggcaa gagggcaacg tgttcagctg cagcgtgatg      300

cacgaggccc tgcacaacca ctacacccag aagtctctga gcctgagcct gggcaag         357


<210>  194
<211>  229
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG4/IgG2 hinge- IgG2/IgG4 CH2- IgG4 CH3 spacer

<400>  194

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Leu Gly Lys Met 
225                 


<210>  195
<211>  687
<212>  DNA
<213>  artificial sequence

<220>
<223>  IgG4/IgG2 hinge- IgG2/IgG4 CH2- IgG4 CH3 spacer

<400>  195
gaatctaagt acggaccgcc ctgccctccc tgccctgctc ctcctgtggc tggaccaagc       60

gtgttcctgt ttccacctaa gcctaaagat accctgatga tttcccgcac acctgaagtg      120

acttgcgtgg tcgtggacgt gagccaggag gatccagaag tgcagttcaa ctggtacgtg      180

gacggcgtgg aagtccacaa tgctaagact aaaccccgag aggaacagtt tcagtcaact      240

taccgggtcg tgagcgtgct gaccgtcctg catcaggatt ggctgaacgg gaaggagtat      300

aagtgcaaag tgtctaataa gggactgcct agctccatcg agaaaacaat tagtaaggca      360

aaagggcagc ctcgagaacc acaggtgtat accctgcccc ctagccagga ggaaatgacc      420

aagaaccagg tgtccctgac atgtctggtc aaaggcttct atccaagtga catcgccgtg      480

gagtgggaat caaatgggca gcccgagaac aattacaaga ccacaccacc cgtgctggac      540

tctgatggaa gtttctttct gtattccagg ctgaccgtgg ataaatctcg ctggcaggag      600

ggcaacgtgt tctcttgcag tgtcatgcac gaagccctgc acaatcatta tacacagaag      660

tcactgagcc tgtccctggg caaaatg                                          687


<210>  196
<211>  687
<212>  DNA
<213>  artificial sequence

<220>
<223>  IgG4/IgG2 hinge- IgG2/IgG4 CH2- IgG4 CH3 spacer O/SSE

<400>  196
gagtctaaat acggaccgcc ttgtcctcct tgtcccgctc ctcctgttgc cggaccttcc       60

gtgttcctgt ttcctccaaa gcctaaggac accctgatga tcagcaggac ccctgaagtg      120

acctgcgtgg tggtggatgt gtcccaagag gatcccgagg tgcagttcaa ctggtatgtg      180

gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagtt ccagagcacc      240

tacagagtgg tgtccgtgct gacagtgctg caccaggatt ggctgaacgg caaagagtac      300

aagtgcaagg tgtccaacaa gggcctgcct agcagcatcg agaaaaccat ctccaaggcc      360

aagggccagc caagagagcc ccaggtttac acactgcctc caagccaaga ggaaatgacc      420

aagaatcagg tgtccctgac atgcctggtc aagggcttct acccctccga tatcgccgtg      480

gaatgggaga gcaatggcca gcctgagaac aactacaaga ccacacctcc tgtgctggac      540

agcgacggca gtttcttcct gtatagtaga ctcaccgtgg ataaatcaag atggcaagag      600

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaaa      660

agcctgagcc tgtctctggg caagatg                                          687


<210>  197
<211>  81
<212>  DNA
<213>  artificial sequence

<220>
<223>  CD28 transmembrane domain

<400>  197
ttttgggtgc tggtcgtggt cggaggggtg ctggcctgtt acagcctgct ggtgacagtc       60

gctttcatca tcttctgggt g                                                 81


<210>  198
<211>  81
<212>  DNA
<213>  artificial sequence

<220>
<223>  CD28 transmembrane domain (O/SSE)

<400>  198
ttctgggtgc tcgtggtcgt tggcggagtg ctggcctgtt acagcctgct ggttaccgtg       60

gccttcatca tcttttgggt c                                                 81


<210>  199
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 1

<400>  199

Phe Arg Ser Thr Ile Tyr Gly Ser Arg Leu Arg Ile Arg Asn Leu 
1               5                   10                  15  


<210>  200
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 2

<400>  200

Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp 
1               5                   10              


<210>  201
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 3

<400>  201

His Cys Lys Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp 
1               5                   10                  


<210>  202
<211>  26
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 4

<400>  202

Trp Phe Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Leu Ser 
1               5                   10                  15      


Phe Arg Ser Thr Ile Tyr Gly Ser Arg Leu 
            20                  25      


<210>  203
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 5

<400>  203

Val Ser Ser Thr Gly Val Leu Phe Val 
1               5                   


<210>  204
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 6

<400>  204

Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro 
1               5                   10              


<210>  205
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 7

<400>  205

Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro 
1               5                   10      


<210>  206
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 8

<400>  206

Gln Pro Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn 
1               5                   10                  


<210>  207
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 9

<400>  207

Ser Gln Phe Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro 
1               5                   10                  


<210>  208
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 10

<400>  208

Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser Val Pro 
1               5                   10          


<210>  209
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 11

<400>  209

Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
1               5                   10                  15      


Ile Leu Met Arg 
            20  


<210>  210
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 12

<400>  210

Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
1               5                   10          


<210>  211
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 13

<400>  211

Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro 
1               5                   10                  15  


<210>  212
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 14

<400>  212

Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg 
1               5                   10                  


<210>  213
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 15

<400>  213

Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
1               5                   10                  


<210>  214
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  ROR1 epitope 16

<400>  214

Asp Ser Lys Glu Lys Asn Lys Met Glu Ile Leu Tyr Ile Leu Val 
1               5                   10                  15  


<210>  215
<211>  937
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  ROR1 (Uniprot Q01973)

<400>  215

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu 
                405                 410                 415     


Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln 
            420                 425                 430         


Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His Val Arg Gly 
        435                 440                 445             


Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys 
    450                 455                 460                 


Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly 
                485                 490                 495     


Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn 
            500                 505                 510         


Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala 
        515                 520                 525             


Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln 
    530                 535                 540                 


Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu 
545                 550                 555                 560 


His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser 
                565                 570                 575     


Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe 
            580                 585                 590         


Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly 
    610                 615                 620                 


Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe 
        675                 680                 685             


Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met 
    690                 695                 700                 


Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg 
705                 710                 715                 720 


Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu 
            740                 745                 750         


Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr 
        755                 760                 765             


Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro 
    770                 775                 780                 


Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly 
785                 790                 795                 800 


Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe 
                805                 810                 815     


Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro 
            820                 825                 830         


Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys 
        835                 840                 845             


Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser 
    850                 855                 860                 


Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala 
865                 870                 875                 880 


Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly 
                885                 890                 895     


Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
            900                 905                 910         


Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His 
        915                 920                 925             


Thr Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935         


<210>  216
<211>  937
<212>  PRT
<213>  Macaca mulatta


<220>
<221>  MISC_FEATURE
<223>  ROR1 (Uniprot F6RUP2)

<400>  216

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu 
                405                 410                 415     


Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln 
            420                 425                 430         


Lys Ser Ser Ser Pro Pro Val Gln Arg Gln Pro Lys His Val Arg Gly 
        435                 440                 445             


Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys 
    450                 455                 460                 


Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly 
                485                 490                 495     


Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn 
            500                 505                 510         


Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala 
        515                 520                 525             


Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln 
    530                 535                 540                 


Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Met Asn Gln Gly Asp Leu 
545                 550                 555                 560 


His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser 
                565                 570                 575     


Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe 
            580                 585                 590         


Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly 
    610                 615                 620                 


Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe 
        675                 680                 685             


Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met 
    690                 695                 700                 


Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg 
705                 710                 715                 720 


Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu 
            740                 745                 750         


Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr 
        755                 760                 765             


Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro 
    770                 775                 780                 


Arg Tyr Pro Asn Tyr Ile Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly 
785                 790                 795                 800 


Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe 
                805                 810                 815     


Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro 
            820                 825                 830         


Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys 
        835                 840                 845             


Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser 
    850                 855                 860                 


Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala 
865                 870                 875                 880 


Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly 
                885                 890                 895     


Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
            900                 905                 910         


Asp Ala Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His 
        915                 920                 925             


Thr Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935         


<210>  217
<211>  923
<212>  PRT
<213>  macaca fasicularis


<220>
<221>  MISC_FEATURE
<223>  ROR1 (Uniprot A0A2K5WTX7)

<400>  217

Met Leu Arg Thr Ala His Lys Leu Leu Tyr Leu Ile Leu Pro Leu Ser 
1               5                   10                  15      


Phe Ser Leu Pro Phe Phe Phe Phe Ser Glu Thr Glu Leu Ser Val Ser 
            20                  25                  30          


Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile Ser Ser Glu Leu Asn 
        35                  40                  45              


Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met Asn Asn Ile Thr Thr 
    50                  55                  60                  


Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys Val Ser Gly Asn Pro 
65                  70                  75                  80  


Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala Pro Val Val Gln Glu 
                85                  90                  95      


Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr Gly Ser Arg Leu Arg 
            100                 105                 110         


Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr Phe Gln Cys Val Ala 
        115                 120                 125             


Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly Val Leu Phe Val Lys 
    130                 135                 140                 


Phe Gly Lys Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg 
145                 150                 155                 160 


Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu 
                165                 170                 175     


Ser Leu His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe 
            180                 185                 190         


Thr Met Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe 
        195                 200                 205             


Ala Ile Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr 
    210                 215                 220                 


Ser Ser Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile 
225                 230                 235                 240 


Leu Glu Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn 
                245                 250                 255     


Pro Met Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro 
            260                 265                 270         


Gln Pro Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro 
        275                 280                 285             


Met Ala Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly 
    290                 295                 300                 


Val Asp Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys 
305                 310                 315                 320 


Gln Pro Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu 
                325                 330                 335     


Arg Phe Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly 
            340                 345                 350         


Asn Gln Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys 
        355                 360                 365             


Ser Asp Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu 
    370                 375                 380                 


Lys Asn Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile 
385                 390                 395                 400 


Pro Leu Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn 
                405                 410                 415     


Asn Gln Lys Ser Ser Ser Pro Pro Val Gln Arg Gln Pro Lys His Val 
            420                 425                 430         


Arg Gly Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys 
        435                 440                 445             


Ser Lys Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu 
    450                 455                 460                 


Leu Gly Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu 
465                 470                 475                 480 


Pro Gly Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp 
                485                 490                 495     


Tyr Asn Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu 
            500                 505                 510         


Met Ala Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val 
        515                 520                 525             


Thr Gln Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Met Asn Gln Gly 
    530                 535                 540                 


Asp Leu His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly 
545                 550                 555                 560 


Cys Ser Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly 
                565                 570                 575     


Asp Phe Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu 
            580                 585                 590         


Ser Ser His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu 
        595                 600                 605             


Ile Gly Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg 
    610                 615                 620                 


Glu Ile Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu 
625                 630                 635                 640 


Pro Ile Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser 
                645                 650                 655     


Ser Asp Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe 
            660                 665                 670         


Ser Phe Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile 
        675                 680                 685             


Glu Met Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro 
    690                 695                 700                 


Pro Arg Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser 
705                 710                 715                 720 


Arg Arg Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu 
                725                 730                 735     


Gly Leu Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala 
            740                 745                 750         


Thr Thr Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser 
        755                 760                 765             


Asn Pro Arg Tyr Pro Asn Tyr Ile Phe Pro Ser Gln Gly Ile Thr Pro 
    770                 775                 780                 


Gln Gly Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln 
785                 790                 795                 800 


Arg Phe Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala 
                805                 810                 815     


Phe Pro Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln 
            820                 825                 830         


His Cys Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser 
        835                 840                 845             


Thr Ser Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln 
    850                 855                 860                 


Glu Ala Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro 
865                 870                 875                 880 


Gly Gly Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr 
                885                 890                 895     


Lys Ile Asp Ala Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His 
            900                 905                 910         


Gly His Thr Glu Ser Met Ile Ser Ala Glu Leu 
        915                 920             


<210>  218
<211>  882
<212>  PRT
<213>  macaca fasicularis


<220>
<221>  MISC_FEATURE
<223>  ROR1 (Uniprot A0A2K5WTX4)

<400>  218

Ser Tyr Leu Thr Leu Asp Glu Pro Met Asn Asn Ile Thr Thr Ser Leu 
1               5                   10                  15      


Gly Gln Thr Ala Glu Leu His Cys Lys Val Ser Gly Asn Pro Pro Pro 
            20                  25                  30          


Thr Ile Arg Trp Phe Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg 
        35                  40                  45              


Arg Leu Ser Phe Arg Ser Thr Ile Tyr Gly Ser Arg Leu Arg Ile Arg 
    50                  55                  60                  


Asn Leu Asp Thr Thr Asp Thr Gly Tyr Phe Gln Cys Val Ala Thr Asn 
65                  70                  75                  80  


Gly Lys Glu Val Val Ser Ser Thr Gly Val Leu Phe Val Lys Phe Gly 
                85                  90                  95      


Pro Pro Pro Thr Ala Ser Pro Gly Tyr Ser Asp Glu Tyr Glu Glu Asp 
            100                 105                 110         


Gly Phe Cys Gln Pro Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly 
        115                 120                 125             


Asn Arg Thr Val Tyr Met Glu Ser Leu His Met Gln Gly Glu Ile Glu 
    130                 135                 140                 


Asn Gln Ile Thr Ala Ala Phe Thr Met Ile Gly Thr Ser Ser His Leu 
145                 150                 155                 160 


Ser Asp Lys Cys Ser Gln Phe Ala Ile Pro Ser Leu Cys His Tyr Ala 
                165                 170                 175     


Phe Pro Tyr Cys Asp Glu Thr Ser Ser Val Pro Lys Pro Arg Asp Leu 
            180                 185                 190         


Cys Arg Asp Glu Cys Glu Ile Leu Glu Asn Val Leu Cys Gln Thr Glu 
        195                 200                 205             


Tyr Ile Phe Ala Arg Ser Asn Pro Met Ile Leu Met Arg Leu Lys Leu 
    210                 215                 220                 


Pro Asn Cys Glu Asp Leu Pro Gln Pro Glu Ser Pro Glu Ala Ala Asn 
225                 230                 235                 240 


Cys Ile Arg Ile Gly Ile Pro Met Ala Asp Pro Ile Asn Lys Asn His 
                245                 250                 255     


Lys Cys Tyr Asn Ser Thr Gly Val Asp Tyr Arg Gly Thr Val Ser Val 
            260                 265                 270         


Thr Lys Ser Gly Arg Gln Cys Gln Pro Trp Asn Ser Gln Tyr Pro His 
        275                 280                 285             


Thr His Thr Phe Thr Ala Leu Arg Phe Pro Glu Leu Asn Gly Gly His 
    290                 295                 300                 


Ser Tyr Cys Arg Asn Pro Gly Asn Gln Lys Glu Ala Pro Trp Cys Phe 
305                 310                 315                 320 


Thr Leu Asp Glu Asn Phe Lys Ser Asp Leu Cys Asp Ile Pro Ala Cys 
                325                 330                 335     


Asp Ser Lys Asp Ser Lys Glu Lys Asn Lys Met Glu Ile Leu Tyr Ile 
            340                 345                 350         


Leu Val Pro Ser Val Ala Ile Pro Leu Ala Ile Ala Leu Leu Phe Phe 
        355                 360                 365             


Phe Ile Cys Val Cys Arg Asn Asn Gln Lys Ser Ser Ser Pro Pro Val 
    370                 375                 380                 


Gln Arg Gln Pro Lys His Val Arg Gly Gln Asn Val Glu Met Ser Met 
385                 390                 395                 400 


Leu Asn Ala Tyr Lys Pro Lys Ser Lys Ala Lys Glu Leu Pro Leu Ser 
                405                 410                 415     


Ala Val Arg Phe Met Glu Glu Leu Gly Glu Cys Ala Phe Gly Lys Ile 
            420                 425                 430         


Tyr Lys Gly His Leu Tyr Leu Pro Gly Met Asp His Ala Gln Leu Val 
        435                 440                 445             


Ala Ile Lys Thr Leu Lys Asp Tyr Asn Asn Pro Gln Gln Trp Thr Glu 
    450                 455                 460                 


Phe Gln Gln Glu Ala Ser Leu Met Ala Glu Leu His His Pro Asn Ile 
465                 470                 475                 480 


Val Cys Leu Leu Gly Ala Val Thr Gln Glu Gln Pro Val Cys Met Leu 
                485                 490                 495     


Phe Glu Tyr Met Asn Gln Gly Asp Leu His Glu Phe Leu Ile Met Arg 
            500                 505                 510         


Ser Pro His Ser Asp Val Gly Cys Ser Ser Asp Glu Asp Gly Thr Val 
        515                 520                 525             


Lys Ser Ser Leu Asp His Gly Asp Phe Leu His Ile Ala Ile Gln Ile 
    530                 535                 540                 


Ala Ala Gly Met Glu Tyr Leu Ser Ser His Phe Phe Val His Lys Asp 
545                 550                 555                 560 


Leu Ala Ala Arg Asn Ile Leu Ile Gly Glu Gln Leu His Val Lys Ile 
                565                 570                 575     


Ser Asp Leu Gly Leu Ser Arg Glu Ile Tyr Ser Ala Asp Tyr Tyr Arg 
            580                 585                 590         


Val Gln Ser Lys Ser Leu Leu Pro Ile Arg Trp Met Pro Pro Glu Ala 
        595                 600                 605             


Ile Met Tyr Gly Lys Phe Ser Ser Asp Ser Asp Ile Trp Ser Phe Gly 
    610                 615                 620                 


Val Val Leu Trp Glu Ile Phe Ser Phe Gly Leu Gln Pro Tyr Tyr Gly 
625                 630                 635                 640 


Phe Ser Asn Gln Glu Val Ile Glu Met Val Arg Lys Arg Gln Leu Leu 
                645                 650                 655     


Pro Cys Ser Glu Asp Cys Pro Pro Arg Met Tyr Ser Leu Met Thr Glu 
            660                 665                 670         


Cys Trp Asn Glu Ile Pro Ser Arg Arg Pro Arg Phe Lys Asp Ile His 
        675                 680                 685             


Val Arg Leu Arg Ser Trp Glu Gly Leu Ser Ser His Thr Ser Ser Thr 
    690                 695                 700                 


Thr Pro Ser Gly Gly Asn Ala Thr Thr Gln Thr Thr Ser Leu Ser Ala 
705                 710                 715                 720 


Ser Pro Val Ser Asn Leu Ser Asn Pro Arg Tyr Pro Asn Tyr Ile Phe 
                725                 730                 735     


Pro Ser Gln Gly Ile Thr Pro Gln Gly Gln Ile Ala Gly Phe Ile Gly 
            740                 745                 750         


Pro Pro Ile Pro Gln Asn Gln Arg Phe Ile Pro Ile Asn Gly Tyr Pro 
        755                 760                 765             


Ile Pro Pro Gly Tyr Ala Ala Phe Pro Ala Ala His Tyr Gln Pro Thr 
    770                 775                 780                 


Gly Pro Pro Arg Val Ile Gln His Cys Pro Pro Pro Lys Ser Arg Ser 
785                 790                 795                 800 


Pro Ser Ser Ala Ser Gly Ser Thr Ser Thr Gly His Val Thr Ser Leu 
                805                 810                 815     


Pro Ser Ser Gly Ser Asn Gln Glu Ala Asn Ile Pro Leu Leu Pro His 
            820                 825                 830         


Met Ser Ile Pro Asn His Pro Gly Gly Met Gly Ile Thr Val Phe Gly 
        835                 840                 845             


Asn Lys Ser Gln Lys Pro Tyr Lys Ile Asp Ala Lys Gln Ala Ser Leu 
    850                 855                 860                 


Leu Gly Asp Ala Asn Ile His Gly His Thr Glu Ser Met Ile Ser Ala 
865                 870                 875                 880 


Glu Leu 
        


<210>  219
<211>  937
<212>  PRT
<213>  mus musculus


<220>
<221>  MISC_FEATURE
<223>  ROR1 (Uniprot Q9Z139)

<400>  219

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Pro Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Asp Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Thr 
        35                  40                  45              


Ser Ser Glu Ile Asp Lys Gly Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Ser Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Ile Ser Phe Arg Ala Thr Asn Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Lys Val Val Ser Thr Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Ser 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Val Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Ser Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu 
                405                 410                 415     


Ala Ile Ala Phe Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln 
            420                 425                 430         


Lys Ser Ser Ser Pro Pro Val Gln Arg Gln Pro Lys Pro Val Arg Gly 
        435                 440                 445             


Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys 
    450                 455                 460                 


Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Cys Thr Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly 
                485                 490                 495     


Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn 
            500                 505                 510         


Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala 
        515                 520                 525             


Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln 
    530                 535                 540                 


Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Met Asn Gln Gly Asp Leu 
545                 550                 555                 560 


His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser 
                565                 570                 575     


Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe 
            580                 585                 590         


Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly 
    610                 615                 620                 


Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Ser Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe 
        675                 680                 685             


Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met 
    690                 695                 700                 


Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg 
705                 710                 715                 720 


Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu 
            740                 745                 750         


Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr 
        755                 760                 765             


Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro 
    770                 775                 780                 


Arg Phe Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly 
785                 790                 795                 800 


Gln Ile Ala Gly Phe Ile Gly Pro Ala Ile Pro Gln Asn Gln Arg Phe 
                805                 810                 815     


Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro 
            820                 825                 830         


Ala Ala His Tyr Gln Pro Ala Gly Pro Pro Arg Val Ile Gln His Cys 
        835                 840                 845             


Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser 
    850                 855                 860                 


Thr Gly His Val Ala Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala 
865                 870                 875                 880 


Asn Val Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly 
                885                 890                 895     


Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
            900                 905                 910         


Asp Ser Lys Gln Ser Ser Leu Leu Gly Asp Ser His Ile His Gly His 
        915                 920                 925             


Thr Glu Ser Met Ile Ser Ala Glu Val 
    930                 935         


