                         SEQUENCE LISTING

<110>  Birad - Research & Development Company Ltd.
 
<120>  COMBINATIONS, NANOPARTICLES AND METHODS FOR CONTROLLING NATURAL 
       KILLER CELL ACTIVATION AND FUNCTION

<130>  2688230

<150>  US 62/797,373
<151>  2019-01-28

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cbl-b siRNA SENSE


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  t is deoxythymine

<400>  1
cccuuauuuc aagcccugat t                                                 21


<210>  2
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cbl-b siRNA SENSE TARGET SEQ

<400>  2
cccttatttc aagccctga                                                    19


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cbl-b siRNA ANTISENSE


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  t is deoxythymine

<400>  3
ucagggcuug aaauaagggt t                                                 21


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cbl-b siRNA ANTISENSE TARGET

<400>  4
tcagggcttg aaataaggg                                                    19


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Cbl siRNA SENSE


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  t is deoxythymine

<400>  5
cuguugacag acagacuaat t                                                 21


<210>  6
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Cbl siRNA SENSE TARGET

<400>  6
ctgttgacag acagactaa                                                    19


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Cbl siRNA ANTISENSE


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  t is deoxythymine

<400>  7
uuagucuguc ugucaacagt t                                                 21


<210>  8
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-Cbl siRNA ANTISENSE TARGET

<400>  8
ttagtctgtc tgtcaacag                                                    19


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SHP-1 siRNA SENSE


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  t is deoxythymine

<400>  9
cccugacccu guggaagcat t                                                 21


<210>  10
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SHP-1 siRNA SENSE TARGET

<400>  10
ccctgaccct gtggaagca                                                    19


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SHP-1 siRNA ANTISENSE


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  t is deoxythymine

<400>  11
ugcuuccaca gggucagggt t                                                 21


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SHP-1 siRNA ANTISENSE TARGET

<400>  12
tgcttccaca gggtcaggg                                                    19


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N.S siRNA SENSE


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  t is deoxythymine

<400>  13
uagcgacuaa acacaucaat t                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N.S siRNA ANTISENSE


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  t is deoxythymine

<400>  14
uugauguguu uagucgcuat t                                                 21


<210>  15
<211>  2949
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Cbl-b, Accession number: NM_170662.5

<400>  15
atggcaaact caatgaatgg cagaaaccct ggtggtcgag gaggaaatcc ccgaaaaggt       60

cgaattttgg gtattattga tgctattcag gatgcagttg gaccccctaa gcaagctgcc      120

gcagatcgca ggaccgtgga gaagacttgg aagctcatgg acaaagtggt aagactgtgc      180

caaaatccca aacttcagtt gaaaaatagc ccaccatata tacttgatat tttgcctgat      240

acatatcagc atttacgact tatattgagt aaatatgatg acaaccagaa acttgcccaa      300

ctcagtgaga atgagtactt taaaatctac attgatagcc ttatgaaaaa gtcaaaacgg      360

gcaataagac tctttaaaga aggcaaggag agaatgtatg aagaacagtc acaggacaga      420

cgaaatctca caaaactgtc ccttatcttc agtcacatgc tggcagaaat caaagcaatc      480

tttcccaatg gtcaattcca gggagataac tttcgtatca caaaagcaga tgctgctgaa      540

ttctggagaa agttttttgg agacaaaact atcgtaccat ggaaagtatt cagacagtgc      600

cttcatgagg tccaccagat tagctctggc ctggaagcaa tggctctaaa atcaacaatt      660

gatttaactt gcaatgatta catttcagtt tttgaatttg atatttttac caggctgttt      720

cagccttggg gctctatttt gcggaattgg aatttcttag ctgtgacaca tccaggttac      780

atggcatttc tcacatatga tgaagttaaa gcacgactac agaaatatag caccaaaccc      840

ggaagctata ttttccggtt aagttgcact cgattgggac agtgggccat tggctatgtg      900

actggggatg ggaatatctt acagaccata cctcataaca agcccttatt tcaagccctg      960

attgatggca gcagggaagg attttatctt tatcctgatg ggaggagtta taatcctgat     1020

ttaactggat tatgtgaacc tacacctcat gaccatataa aagttacaca ggaacaatat     1080

gaattatatt gtgaaatggg ctccactttt cagctctgta agatttgtgc agagaatgac     1140

aaagatgtca agattgagcc ttgtgggcat ttgatgtgca cctcttgcct tacggcatgg     1200

caggagtcgg atggtcaggg ctgccctttc tgtcgttgtg aaataaaagg aactgagccc     1260

ataatcgtgg acccctttga tccaagagat gaaggctcca ggtgttgcag catcattgac     1320

ccctttggca tgccgatgct agacttggac gacgatgatg atcgtgagga gtccttgatg     1380

atgaatcggt tggcaaacgt ccgaaagtgc actgacaggc agaactcacc agtcacatca     1440

ccaggatcct ctccccttgc ccagagaaga aagccacagc ctgacccact ccagatccca     1500

catctaagcc tgccacccgt gcctcctcgc ctggatctaa ttcagaaagg catagttaga     1560

tctccctgtg gcagcccaac gggttcacca aagtcttctc cttgcatggt gagaaaacaa     1620

gataaaccac tcccagcacc acctcctccc ttaagagatc ctcctccacc gccacctgaa     1680

agacctccac caatcccacc agacaataga ctgagtagac acatccatca tgtggaaagc     1740

gtgccttcca gagacccgcc aatgcctctt gaagcatggt gccctcggga tgtgtttggg     1800

actaatcagc ttgtgggatg tcgactccta ggggagggct ctccaaaacc tggaatcaca     1860

gcgagttcaa atgtcaatgg aaggcacagt agagtgggct ctgacccagt gcttatgcgg     1920

aaacacagac gccatgattt gcctttagaa ggagctaagg tcttttccaa tggtcacctt     1980

ggaagtgaag aatatgatgt tcctccccgg ctttctcctc ctcctccagt taccaccctc     2040

ctccctagca taaagtgtac tggtccgtta gcaaattctc tttcagagaa aacaagagac     2100

ccagtagagg aagatgatga tgaatacaag attccttcat cccaccctgt ttccctgaat     2160

tcacaaccat ctcattgtca taatgtaaaa cctcctgttc ggtcttgtga taatggtcac     2220

tgtatgctga atggaacaca tggtccatct tcagagaaga aatcaaacat ccctgactta     2280

agcatatatt taaagggaga tgtttttgat tcagcctctg atcccgtgcc attaccacct     2340

gccaggcctc caactcggga caatccaaag catggttctt cactcaacag gacgccctct     2400

gattatgatc ttctcatccc tccattaggt gaagatgctt ttgatgccct ccctccatct     2460

ctcccacctc ccccacctcc tgcaaggcat agtctcattg aacattcaaa acctcctggc     2520

tccagtagcc ggccatcctc aggacaggat ctttttcttc ttccttcaga tccctttgtt     2580

gatctagcaa gtggccaagt tcctttgcct cctgctagaa ggttaccagg tgaaaatgtc     2640

aaaactaaca gaacatcaca ggactatgat cagcttcctt catgttcaga tggttcacag     2700

gcaccagcca gaccccctaa accacgaccg cgcaggactg caccagaaat tcaccacaga     2760

aaaccccatg ggcctgaggc ggcattggaa aatgtcgatg caaaaattgc aaaactcatg     2820

ggagagggtt atgcctttga agaggtgaag agagccttag agatagccca gaataatgtc     2880

gaagttgccc ggagcatcct ccgagaattt gccttccctc ctccagtatc cccacgtcta     2940

aatctatag                                                             2949


<210>  16
<211>  982
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Cbl-b, Accession number: NP_733762.2

<400>  16

Met Ala Asn Ser Met Asn Gly Arg Asn Pro Gly Gly Arg Gly Gly Asn 
1               5                   10                  15      


Pro Arg Lys Gly Arg Ile Leu Gly Ile Ile Asp Ala Ile Gln Asp Ala 
            20                  25                  30          


Val Gly Pro Pro Lys Gln Ala Ala Ala Asp Arg Arg Thr Val Glu Lys 
        35                  40                  45              


Thr Trp Lys Leu Met Asp Lys Val Val Arg Leu Cys Gln Asn Pro Lys 
    50                  55                  60                  


Leu Gln Leu Lys Asn Ser Pro Pro Tyr Ile Leu Asp Ile Leu Pro Asp 
65                  70                  75                  80  


Thr Tyr Gln His Leu Arg Leu Ile Leu Ser Lys Tyr Asp Asp Asn Gln 
                85                  90                  95      


Lys Leu Ala Gln Leu Ser Glu Asn Glu Tyr Phe Lys Ile Tyr Ile Asp 
            100                 105                 110         


Ser Leu Met Lys Lys Ser Lys Arg Ala Ile Arg Leu Phe Lys Glu Gly 
        115                 120                 125             


Lys Glu Arg Met Tyr Glu Glu Gln Ser Gln Asp Arg Arg Asn Leu Thr 
    130                 135                 140                 


Lys Leu Ser Leu Ile Phe Ser His Met Leu Ala Glu Ile Lys Ala Ile 
145                 150                 155                 160 


Phe Pro Asn Gly Gln Phe Gln Gly Asp Asn Phe Arg Ile Thr Lys Ala 
                165                 170                 175     


Asp Ala Ala Glu Phe Trp Arg Lys Phe Phe Gly Asp Lys Thr Ile Val 
            180                 185                 190         


Pro Trp Lys Val Phe Arg Gln Cys Leu His Glu Val His Gln Ile Ser 
        195                 200                 205             


Ser Gly Leu Glu Ala Met Ala Leu Lys Ser Thr Ile Asp Leu Thr Cys 
    210                 215                 220                 


Asn Asp Tyr Ile Ser Val Phe Glu Phe Asp Ile Phe Thr Arg Leu Phe 
225                 230                 235                 240 


Gln Pro Trp Gly Ser Ile Leu Arg Asn Trp Asn Phe Leu Ala Val Thr 
                245                 250                 255     


His Pro Gly Tyr Met Ala Phe Leu Thr Tyr Asp Glu Val Lys Ala Arg 
            260                 265                 270         


Leu Gln Lys Tyr Ser Thr Lys Pro Gly Ser Tyr Ile Phe Arg Leu Ser 
        275                 280                 285             


Cys Thr Arg Leu Gly Gln Trp Ala Ile Gly Tyr Val Thr Gly Asp Gly 
    290                 295                 300                 


Asn Ile Leu Gln Thr Ile Pro His Asn Lys Pro Leu Phe Gln Ala Leu 
305                 310                 315                 320 


Ile Asp Gly Ser Arg Glu Gly Phe Tyr Leu Tyr Pro Asp Gly Arg Ser 
                325                 330                 335     


Tyr Asn Pro Asp Leu Thr Gly Leu Cys Glu Pro Thr Pro His Asp His 
            340                 345                 350         


Ile Lys Val Thr Gln Glu Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser 
        355                 360                 365             


Thr Phe Gln Leu Cys Lys Ile Cys Ala Glu Asn Asp Lys Asp Val Lys 
    370                 375                 380                 


Ile Glu Pro Cys Gly His Leu Met Cys Thr Ser Cys Leu Thr Ala Trp 
385                 390                 395                 400 


Gln Glu Ser Asp Gly Gln Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys 
                405                 410                 415     


Gly Thr Glu Pro Ile Ile Val Asp Pro Phe Asp Pro Arg Asp Glu Gly 
            420                 425                 430         


Ser Arg Cys Cys Ser Ile Ile Asp Pro Phe Gly Met Pro Met Leu Asp 
        435                 440                 445             


Leu Asp Asp Asp Asp Asp Arg Glu Glu Ser Leu Met Met Asn Arg Leu 
    450                 455                 460                 


Ala Asn Val Arg Lys Cys Thr Asp Arg Gln Asn Ser Pro Val Thr Ser 
465                 470                 475                 480 


Pro Gly Ser Ser Pro Leu Ala Gln Arg Arg Lys Pro Gln Pro Asp Pro 
                485                 490                 495     


Leu Gln Ile Pro His Leu Ser Leu Pro Pro Val Pro Pro Arg Leu Asp 
            500                 505                 510         


Leu Ile Gln Lys Gly Ile Val Arg Ser Pro Cys Gly Ser Pro Thr Gly 
        515                 520                 525             


Ser Pro Lys Ser Ser Pro Cys Met Val Arg Lys Gln Asp Lys Pro Leu 
    530                 535                 540                 


Pro Ala Pro Pro Pro Pro Leu Arg Asp Pro Pro Pro Pro Pro Pro Glu 
545                 550                 555                 560 


Arg Pro Pro Pro Ile Pro Pro Asp Asn Arg Leu Ser Arg His Ile His 
                565                 570                 575     


His Val Glu Ser Val Pro Ser Arg Asp Pro Pro Met Pro Leu Glu Ala 
            580                 585                 590         


Trp Cys Pro Arg Asp Val Phe Gly Thr Asn Gln Leu Val Gly Cys Arg 
        595                 600                 605             


Leu Leu Gly Glu Gly Ser Pro Lys Pro Gly Ile Thr Ala Ser Ser Asn 
    610                 615                 620                 


Val Asn Gly Arg His Ser Arg Val Gly Ser Asp Pro Val Leu Met Arg 
625                 630                 635                 640 


Lys His Arg Arg His Asp Leu Pro Leu Glu Gly Ala Lys Val Phe Ser 
                645                 650                 655     


Asn Gly His Leu Gly Ser Glu Glu Tyr Asp Val Pro Pro Arg Leu Ser 
            660                 665                 670         


Pro Pro Pro Pro Val Thr Thr Leu Leu Pro Ser Ile Lys Cys Thr Gly 
        675                 680                 685             


Pro Leu Ala Asn Ser Leu Ser Glu Lys Thr Arg Asp Pro Val Glu Glu 
    690                 695                 700                 


Asp Asp Asp Glu Tyr Lys Ile Pro Ser Ser His Pro Val Ser Leu Asn 
705                 710                 715                 720 


Ser Gln Pro Ser His Cys His Asn Val Lys Pro Pro Val Arg Ser Cys 
                725                 730                 735     


Asp Asn Gly His Cys Met Leu Asn Gly Thr His Gly Pro Ser Ser Glu 
            740                 745                 750         


Lys Lys Ser Asn Ile Pro Asp Leu Ser Ile Tyr Leu Lys Gly Asp Val 
        755                 760                 765             


Phe Asp Ser Ala Ser Asp Pro Val Pro Leu Pro Pro Ala Arg Pro Pro 
    770                 775                 780                 


Thr Arg Asp Asn Pro Lys His Gly Ser Ser Leu Asn Arg Thr Pro Ser 
785                 790                 795                 800 


Asp Tyr Asp Leu Leu Ile Pro Pro Leu Gly Glu Asp Ala Phe Asp Ala 
                805                 810                 815     


Leu Pro Pro Ser Leu Pro Pro Pro Pro Pro Pro Ala Arg His Ser Leu 
            820                 825                 830         


Ile Glu His Ser Lys Pro Pro Gly Ser Ser Ser Arg Pro Ser Ser Gly 
        835                 840                 845             


Gln Asp Leu Phe Leu Leu Pro Ser Asp Pro Phe Val Asp Leu Ala Ser 
    850                 855                 860                 


Gly Gln Val Pro Leu Pro Pro Ala Arg Arg Leu Pro Gly Glu Asn Val 
865                 870                 875                 880 


Lys Thr Asn Arg Thr Ser Gln Asp Tyr Asp Gln Leu Pro Ser Cys Ser 
                885                 890                 895     


Asp Gly Ser Gln Ala Pro Ala Arg Pro Pro Lys Pro Arg Pro Arg Arg 
            900                 905                 910         


Thr Ala Pro Glu Ile His His Arg Lys Pro His Gly Pro Glu Ala Ala 
        915                 920                 925             


Leu Glu Asn Val Asp Ala Lys Ile Ala Lys Leu Met Gly Glu Gly Tyr 
    930                 935                 940                 


Ala Phe Glu Glu Val Lys Arg Ala Leu Glu Ile Ala Gln Asn Asn Val 
945                 950                 955                 960 


Glu Val Ala Arg Ser Ile Leu Arg Glu Phe Ala Phe Pro Pro Pro Val 
                965                 970                 975     


Ser Pro Arg Leu Asn Leu 
            980         


<210>  17
<211>  906
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  c-Cbl, Accession number: NP_005179.2

<400>  17

Met Ala Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Ser Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala 
            20                  25                  30          


Phe Gln Pro His His His His His His His Leu Ser Pro His Pro Pro 
        35                  40                  45              


Gly Thr Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp 
    50                  55                  60                  


Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser 
65                  70                  75                  80  


Pro Pro Tyr Ile Leu Asp Leu Leu Pro Asp Thr Tyr Gln His Leu Arg 
                85                  90                  95      


Thr Ile Leu Ser Arg Tyr Glu Gly Lys Met Glu Thr Leu Gly Glu Asn 
            100                 105                 110         


Glu Tyr Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Thr Lys Gln 
        115                 120                 125             


Thr Ile Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn 
    130                 135                 140                 


Ser Gln Pro Arg Arg Asn Leu Thr Lys Leu Ser Leu Ile Phe Ser His 
145                 150                 155                 160 


Met Leu Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly 
                165                 170                 175     


Asp Thr Phe Arg Ile Thr Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys 
            180                 185                 190         


Ala Phe Gly Glu Lys Thr Ile Val Pro Trp Lys Ser Phe Arg Gln Ala 
        195                 200                 205             


Leu His Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu 
    210                 215                 220                 


Lys Ser Thr Ile Asp Leu Thr Cys Asn Asp Tyr Ile Ser Val Phe Glu 
225                 230                 235                 240 


Phe Asp Ile Phe Thr Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg 
                245                 250                 255     


Asn Trp Asn Ser Leu Ala Val Thr His Pro Gly Tyr Met Ala Phe Leu 
            260                 265                 270         


Thr Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro 
        275                 280                 285             


Gly Ser Tyr Ile Phe Arg Leu Ser Cys Thr Arg Leu Gly Gln Trp Ala 
    290                 295                 300                 


Ile Gly Tyr Val Thr Ala Asp Gly Asn Ile Leu Gln Thr Ile Pro His 
305                 310                 315                 320 


Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe 
                325                 330                 335     


Tyr Leu Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Thr Gly Leu 
            340                 345                 350         


Cys Glu Pro Thr Pro Gln Asp His Ile Lys Val Thr Gln Glu Gln Tyr 
        355                 360                 365             


Glu Leu Tyr Cys Glu Met Gly Ser Thr Phe Gln Leu Cys Lys Ile Cys 
    370                 375                 380                 


Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met 
385                 390                 395                 400 


Cys Thr Ser Cys Leu Thr Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys 
                405                 410                 415     


Pro Phe Cys Arg Cys Glu Ile Lys Gly Thr Glu Pro Ile Val Val Asp 
            420                 425                 430         


Pro Phe Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu 
        435                 440                 445             


Gly Ala Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp 
    450                 455                 460                 


Asp Thr Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg 
465                 470                 475                 480 


Pro Pro Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val 
                485                 490                 495     


Pro Pro Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser 
            500                 505                 510         


Ala Ser Ala Leu Gly Thr Ala Ser Lys Ala Ala Ser Gly Ser Leu His 
        515                 520                 525             


Lys Asp Lys Pro Leu Pro Val Pro Pro Thr Leu Arg Asp Leu Pro Pro 
    530                 535                 540                 


Pro Pro Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro 
545                 550                 555                 560 


Gln Arg Arg Pro Leu Pro Cys Thr Pro Gly Asp Cys Pro Ser Arg Asp 
                565                 570                 575     


Lys Leu Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro 
            580                 585                 590         


Arg Pro Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro 
        595                 600                 605             


Trp Thr Gly Arg Glu Leu Thr Asn Arg His Ser Leu Pro Phe Ser Leu 
    610                 615                 620                 


Pro Ser Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Thr 
625                 630                 635                 640 


Phe Ser Leu Asp Thr Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly 
                645                 650                 655     


Pro Glu Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala 
            660                 665                 670         


Ile Tyr Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro 
        675                 680                 685             


Gly Glu Gln Cys Glu Gly Glu Glu Asp Thr Glu Tyr Met Thr Pro Ser 
    690                 695                 700                 


Ser Arg Pro Leu Arg Pro Leu Asp Thr Ser Gln Ser Ser Arg Ala Cys 
705                 710                 715                 720 


Asp Cys Asp Gln Gln Ile Asp Ser Cys Thr Tyr Glu Ala Met Tyr Asn 
                725                 730                 735     


Ile Gln Ser Gln Ala Pro Ser Ile Thr Glu Ser Ser Thr Phe Gly Glu 
            740                 745                 750         


Gly Asn Leu Ala Ala Ala His Ala Asn Thr Gly Pro Glu Glu Ser Glu 
        755                 760                 765             


Asn Glu Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val 
    770                 775                 780                 


Leu Ala Arg Arg Thr Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe 
785                 790                 795                 800 


Gly Trp Leu Ser Leu Asp Gly Asp Pro Thr Thr Asn Val Thr Glu Gly 
                805                 810                 815     


Ser Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn 
            820                 825                 830         


Ser Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser Gly Pro Ala Ala 
        835                 840                 845             


Ser Ala Ala Thr Ala Ser Pro Gln Leu Ser Ser Glu Ile Glu Asn Leu 
    850                 855                 860                 


Met Ser Gln Gly Tyr Ser Tyr Gln Asp Ile Gln Lys Ala Leu Val Ile 
865                 870                 875                 880 


Ala Gln Asn Asn Ile Glu Met Ala Lys Asn Ile Leu Arg Glu Phe Val 
                885                 890                 895     


Ser Ile Ser Ser Pro Ala His Val Ala Thr 
            900                 905     


<210>  18
<211>  2721
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  c-Cbl, Accession number: NM_005188.3

<400>  18
atggccggca acgtgaagaa gagctctggg gccgggggcg gcagcggctc cgggggctcg       60

ggttcgggtg gcctgattgg gctcatgaag gacgccttcc agccgcacca ccaccaccac      120

caccacctca gcccccaccc gccggggacg gtggacaaga agatggtgga gaagtgctgg      180

aagctcatgg acaaggtggt gcggttgtgt cagaacccaa agctggcgct aaagaatagc      240

ccaccttata tcttagacct gctaccagat acctaccagc atctccgtac tatcttgtca      300

agatatgagg ggaagatgga gacacttgga gaaaatgagt attttagggt gtttatggag      360

aatttgatga agaaaactaa gcaaaccata agcctcttca aggagggaaa agaaagaatg      420

tatgaggaga attctcagcc taggcgaaac ctaaccaaac tgtccctcat cttcagccac      480

atgctggcag aactaaaagg aatctttcca agtggactct ttcagggaga cacatttcgg      540

attactaaag cagatgctgc ggaattttgg agaaaagctt ttggggaaaa gacaatagtc      600

ccttggaaga gctttcgaca ggctctacat gaagtgcatc ccatcagttc tgggctggag      660

gccatggctc tgaaatccac tattgatctg acctgcaatg attatatttc ggtttttgaa      720

tttgacatct ttacccgact ctttcagccc tggtcctctt tgctcaggaa ttggaacagc      780

cttgctgtaa ctcatcctgg ctacatggct tttttgacgt atgacgaagt gaaagctcgg      840

ctccagaaat tcattcacaa acctggcagt tatatcttcc ggctgagctg tactcgtctg      900

ggtcagtggg ctattgggta tgttactgct gatgggaaca ttctccagac aatccctcac      960

aataaacctc tcttccaagc actgattgat ggcttcaggg aaggcttcta tttgtttcct     1020

gatggacgaa atcagaatcc tgatctgact ggcttatgtg aaccaactcc ccaagaccat     1080

atcaaagtga cccaggaaca atatgaatta tactgtgaga tgggctccac attccaacta     1140

tgtaaaatat gtgctgaaaa tgataaggat gtaaagattg agccctgtgg acacctcatg     1200

tgcacatcct gtcttacatc ctggcaggaa tcagaaggtc agggctgtcc tttctgccga     1260

tgtgaaatta aaggtactga acccatcgtg gtagatccgt ttgatcctag agggagtggc     1320

agcctgttga ggcaaggagc agagggagct ccctccccaa attatgatga tgatgatgat     1380

gaacgagctg atgatactct cttcatgatg aaggaattgg ctggtgccaa ggtggaacgg     1440

ccgccttctc cattctccat ggccccacaa gcttcccttc ccccggtgcc accacgactt     1500

gaccttctgc cgcagcgagt atgtgttccc tcaagtgctt ctgctcttgg aactgcttct     1560

aaggctgctt ctggctccct tcataaagac aaaccattgc cagtacctcc cacacttcga     1620

gatcttccac caccaccgcc tccagaccgg ccatattctg ttggagcaga atcccgacct     1680

caaagacgcc ccttgccttg tacaccaggc gactgtccct ccagagacaa actgccccct     1740

gtcccctcta gccgccttgg agactcatgg ctgccccggc caatccccaa agtaccagta     1800

tctgccccaa gttccagtga tccctggaca ggaagagaat taaccaaccg gcactcactt     1860

ccattttcat tgccctcaca aatggagccc agaccagatg tgcctaggct cggaagcacg     1920

ttcagtctgg atacctccat gagtatgaat agcagcccat tagtaggtcc agagtgtgac     1980

caccccaaaa tcaaaccttc ctcatctgcc aatgccattt attctctggc tgccagacct     2040

cttcctgtgc caaaactgcc acctggggag caatgtgagg gtgaagagga cacagagtac     2100

atgactccct cttccaggcc tctacggcct ttggatacat cccagagttc acgagcatgt     2160

gattgcgacc agcagattga tagctgtacg tatgaagcaa tgtataatat tcagtcccag     2220

gcgccatcta tcaccgagag cagcaccttt ggtgaaggga atttggccgc agcccatgcc     2280

aacactggtc ccgaggagtc agaaaatgag gatgatgggt atgatgtccc aaagccacct     2340

gtgccggccg tgctggcccg ccgaactctc tcagatatct ctaatgccag ctcctccttt     2400

ggctggttgt ctctggatgg tgatcctaca acaaatgtca ctgaaggttc ccaagttccc     2460

gagaggcctc caaaaccatt cccgcggaga atcaactctg aacggaaagc tggcagctgt     2520

cagcaaggta gtggtcctgc cgcctctgct gccaccgcct cacctcagct ctccagtgag     2580

atcgagaacc tcatgagtca ggggtactcc taccaggaca tccagaaagc tttggtcatt     2640

gcccagaaca acatcgagat ggccaaaaac atcctccggg aatttgtttc catttcttct     2700

cctgcccatg tagctaccta g                                               2721


<210>  19
<211>  474
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CBL-3, Accession number: NP_036248.3

<400>  19

Met Ala Leu Ala Val Ala Pro Trp Gly Arg Gln Trp Glu Glu Ala Arg 
1               5                   10                  15      


Ala Leu Gly Arg Ala Val Arg Met Leu Gln Arg Leu Glu Glu Gln Cys 
            20                  25                  30          


Val Asp Pro Arg Leu Ser Val Ser Pro Pro Ser Leu Arg Asp Leu Leu 
        35                  40                  45              


Pro Arg Thr Ala Gln Leu Leu Arg Glu Val Ala His Ser Arg Arg Ala 
    50                  55                  60                  


Ala Gly Gly Gly Gly Pro Gly Gly Pro Gly Gly Ser Gly Asp Phe Leu 
65                  70                  75                  80  


Leu Ile Tyr Leu Ala Asn Leu Glu Ala Lys Ser Arg Gln Val Ala Ala 
                85                  90                  95      


Leu Leu Pro Pro Arg Gly Arg Arg Ser Ala Asn Asp Glu Leu Phe Arg 
            100                 105                 110         


Ala Gly Ser Arg Leu Arg Arg Gln Leu Ala Lys Leu Ala Ile Ile Phe 
        115                 120                 125             


Ser His Met His Ala Glu Leu His Ala Leu Phe Pro Gly Gly Lys Tyr 
    130                 135                 140                 


Cys Gly His Met Tyr Gln Leu Thr Lys Ala Pro Ala His Thr Phe Trp 
145                 150                 155                 160 


Arg Glu Ser Cys Gly Ala Arg Cys Val Leu Pro Trp Ala Glu Phe Glu 
                165                 170                 175     


Ser Leu Leu Gly Thr Cys His Pro Val Glu Pro Gly Cys Thr Ala Leu 
            180                 185                 190         


Ala Leu Arg Thr Thr Ile Asp Leu Thr Cys Ser Gly His Val Ser Ile 
        195                 200                 205             


Phe Glu Phe Asp Val Phe Thr Arg Leu Phe Gln Pro Trp Pro Thr Leu 
    210                 215                 220                 


Leu Lys Asn Trp Gln Leu Leu Ala Val Asn His Pro Gly Tyr Met Ala 
225                 230                 235                 240 


Phe Leu Thr Tyr Asp Glu Val Gln Glu Arg Leu Gln Ala Cys Arg Asp 
                245                 250                 255     


Lys Pro Gly Ser Tyr Ile Phe Arg Pro Ser Cys Thr Arg Leu Gly Gln 
            260                 265                 270         


Trp Ala Ile Gly Tyr Val Ser Ser Asp Gly Ser Ile Leu Gln Thr Ile 
        275                 280                 285             


Pro Ala Asn Lys Pro Leu Ser Gln Val Leu Leu Glu Gly Gln Lys Asp 
    290                 295                 300                 


Gly Phe Tyr Leu Tyr Pro Asp Gly Lys Thr His Asn Pro Asp Leu Thr 
305                 310                 315                 320 


Glu Leu Gly Gln Ala Glu Pro Gln Gln Arg Ile His Val Ser Glu Glu 
                325                 330                 335     


Gln Leu Gln Leu Tyr Trp Ala Met Asp Ser Thr Phe Glu Leu Cys Lys 
            340                 345                 350         


Ile Cys Ala Glu Ser Asn Lys Asp Val Lys Ile Glu Pro Cys Gly His 
        355                 360                 365             


Leu Leu Cys Ser Cys Cys Leu Ala Ala Trp Gln His Ser Asp Ser Gln 
    370                 375                 380                 


Thr Cys Pro Phe Cys Arg Cys Glu Ile Lys Gly Trp Glu Ala Val Ser 
385                 390                 395                 400 


Ile Tyr Gln Phe His Gly Gln Ala Thr Ala Glu Asp Ser Gly Asn Ser 
                405                 410                 415     


Ser Asp Gln Glu Gly Arg Glu Leu Glu Leu Gly Gln Val Pro Leu Ser 
            420                 425                 430         


Ala Pro Pro Leu Pro Pro Arg Pro Asp Leu Pro Pro Arg Lys Pro Arg 
        435                 440                 445             


Asn Ala Gln Pro Lys Val Arg Leu Leu Lys Gly Asn Ser Pro Pro Ala 
    450                 455                 460                 


Ala Leu Gly Pro Gln Asp Pro Ala Pro Ala 
465                 470                 


<210>  20
<211>  1425
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CBL-3, Accession number: NM_012116.4

<400>  20
atggctctgg cggtggcccc gtgggggcga cagtgggaag aggcccgcgc cctgggccgg       60

gcagtcagga tgctgcagcg cctagaagag caatgcgtcg acccccggct gtccgtgagt      120

cccccttcgc tgcgggacct gctgccccgc acagcgcagc tgcttcgaga ggtggcccat      180

tctcggcggg cggccggcgg aggcggcccc gggggtcccg gcggctctgg ggactttcta      240

ctcatctacc tggccaatct ggaggccaag agcaggcagg tggccgcgct gctgcctccc      300

cggggccgaa ggagtgccaa cgacgagctc ttccgggcgg gctccagact caggcgacag      360

ctggccaagc tggccatcat cttcagccac atgcacgcag agctgcacgc actcttcccc      420

gggggaaagt actgtggaca catgtaccag ctcaccaagg cccccgccca caccttctgg      480

agggaaagtt gcggagcccg gtgtgtgctg ccctgggctg agtttgagtc cctcctgggc      540

acctgccacc ctgtggaacc aggctgcaca gccctggcct tgcgcaccac cattgacctc      600

acctgcagcg ggcacgtgtc catcttcgag ttcgacgtct tcaccaggct ctttcagcca      660

tggccaacac tcctcaagaa ctggcagctc ctggcagtca accacccagg ctacatggcc      720

ttcctcacct atgatgaggt ccaagagcgt ctgcaggcct gcagggacaa gccaggcagt      780

tacatcttcc ggcccagctg tactcgcctg gggcagtggg ccatcggcta tgtgagctca      840

gatggcagca tcctgcagac catccctgcc aacaaacccc tgtcccaggt gctcctggag      900

ggacagaagg acggcttcta cctctaccca gatggaaaga cccacaaccc agacctgact      960

gagctcggcc aggcagaacc ccagcagcgc atccacgtgt cagaggagca gctgcagctc     1020

tactgggcca tggactccac atttgagctc tgcaagatct gtgctgagag caacaaggat     1080

gtgaagattg agccgtgcgg gcacctgctc tgcagctgct gcctggctgc ctggcagcac     1140

tcggacagcc agacctgccc cttctgccgc tgcgagatca agggctggga ggccgtgagt     1200

atctaccagt tccacggtca ggctactgct gaggactcag ggaacagcag tgaccaggaa     1260

ggcagggagt tggagctggg gcaggtgccc ctttcggctc ctccattgcc cccacggcca     1320

gatctgcccc ccaggaagcc cagaaatgcc cagccgaaag tgagactcct aaaggggaac     1380

tcccctccag ctgcgctggg accccaggac cctgccccgg cctga                     1425


<210>  21
<211>  1788
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  PTPN6 cDNA, transcript variant 1, NM_002831.5

<400>  21
atggtgaggt ggtttcaccg agacctcagt gggctggatg cagagaccct gctcaagggc       60

cgaggtgtcc acggtagctt cctggctcgg cccagtcgca agaaccaggg tgacttctcg      120

ctctccgtca gggtggggga tcaggtgacc catattcgga tccagaactc aggggatttc      180

tatgacctgt atggagggga gaagtttgcg actctgacag agctggtgga gtactacact      240

cagcagcagg gtgtcctgca ggaccgcgac ggcaccatca tccacctcaa gtacccgctg      300

aactgctccg atcccactag tgagaggtgg taccatggcc acatgtctgg cgggcaggca      360

gagacgctgc tgcaggccaa gggcgagccc tggacgtttc ttgtgcgtga gagcctcagc      420

cagcctggag acttcgtgct ttctgtgctc agtgaccagc ccaaggctgg cccaggctcc      480

ccgctcaggg tcacccacat caaggtcatg tgcgagggtg gacgctacac agtgggtggt      540

ttggagacct tcgacagcct cacggacctg gtggagcatt tcaagaagac ggggattgag      600

gaggcctcag gcgcctttgt ctacctgcgg cagccgtact atgccacgag ggtgaatgcg      660

gctgacattg agaaccgagt gttggaactg aacaagaagc aggagtccga ggatacagcc      720

aaggctggct tctgggagga gtttgagagt ttgcagaagc aggaggtgaa gaacttgcac      780

cagcgtctgg aagggcagcg gccagagaac aagggcaaga accgctacaa gaacattctc      840

ccctttgacc acagccgagt gatcctgcag ggacgggaca gtaacatccc cgggtccgac      900

tacatcaatg ccaactacat caagaaccag ctgctaggcc ctgatgagaa cgctaagacc      960

tacatcgcca gccagggctg tctggaggcc acggtcaatg acttctggca gatggcgtgg     1020

caggagaaca gccgtgtcat cgtcatgacc acccgagagg tggagaaagg ccggaacaaa     1080

tgcgtcccat actggcccga ggtgggcatg cagcgtgctt atgggcccta ctctgtgacc     1140

aactgcgggg agcatgacac aaccgaatac aaactccgta ccttacaggt ctccccgctg     1200

gacaatggag acctgattcg ggagatctgg cattaccagt acctgagctg gcccgaccat     1260

ggggtcccca gtgagcctgg gggtgtcctc agcttcctgg accagatcaa ccagcggcag     1320

gaaagtctgc ctcacgcagg gcccatcatc gtgcactgca gcgccggcat cggccgcaca     1380

ggcaccatca ttgtcatcga catgctcatg gagaacatct ccaccaaggg cctggactgt     1440

gacattgaca tccagaagac catccagatg gtgcgggcgc agcgctcggg catggtgcag     1500

acggaggcgc agtacaagtt catctacgtg gccatcgccc agttcattga aaccactaag     1560

aagaagctgg aggtcctgca gtcgcagaag ggccaggagt cggagtacgg gaacatcacc     1620

tatcccccag ccatgaagaa tgcccatgcc aaggcctccc gcacctcgtc caaacacaag     1680

gaggatgtgt atgagaacct gcacactaag aacaagaggg aggagaaagt gaagaagcag     1740

cggtcagcag acaaggagaa gagcaagggt tccctcaaga ggaagtga                  1788


<210>  22
<211>  595
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  tyrosine-protein phosphatase non-receptor type 6 isoform 1, 
       NP_002822.2

<400>  22

Met Val Arg Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala Glu Thr 
1               5                   10                  15      


Leu Leu Lys Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg Pro Ser 
            20                  25                  30          


Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly Asp Gln 
        35                  40                  45              


Val Thr His Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp Leu Tyr 
    50                  55                  60                  


Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr Tyr Thr 
65                  70                  75                  80  


Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile His Leu 
                85                  90                  95      


Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Ser Glu Arg Trp Tyr His 
            100                 105                 110         


Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala Lys Gly 
        115                 120                 125             


Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro Gly Asp 
    130                 135                 140                 


Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro Gly Ser 
145                 150                 155                 160 


Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly Gly Arg Tyr 
                165                 170                 175     


Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp Leu Val Glu 
            180                 185                 190         


His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe Val Tyr 
        195                 200                 205             


Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val Asn Ala Ala Asp Ile Glu 
    210                 215                 220                 


Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Glu Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val 
                245                 250                 255     


Lys Asn Leu His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly 
            260                 265                 270         


Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile 
        275                 280                 285             


Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala 
    290                 295                 300                 


Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr 
305                 310                 315                 320 


Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp 
                325                 330                 335     


Gln Met Ala Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg 
            340                 345                 350         


Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val 
        355                 360                 365             


Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu 
    370                 375                 380                 


His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu 
385                 390                 395                 400 


Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser 
                405                 410                 415     


Trp Pro Asp His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe 
            420                 425                 430         


Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro 
        435                 440                 445             


Ile Ile Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile 
    450                 455                 460                 


Val Ile Asp Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys 
465                 470                 475                 480 


Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser 
                485                 490                 495     


Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile 
            500                 505                 510         


Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Leu Glu Val Leu Gln Ser 
        515                 520                 525             


Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Ile Thr Tyr Pro Pro Ala 
    530                 535                 540                 


Met Lys Asn Ala His Ala Lys Ala Ser Arg Thr Ser Ser Lys His Lys 
545                 550                 555                 560 


Glu Asp Val Tyr Glu Asn Leu His Thr Lys Asn Lys Arg Glu Glu Lys 
                565                 570                 575     


Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Lys Ser Lys Gly Ser Leu 
            580                 585                 590         


Lys Arg Lys 
        595 


<210>  23
<211>  1794
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  PTPN6 transcript variant 2, cDNA, NM_080548.4

<400>  23
atgctgtccc gtgggtggtt tcaccgagac ctcagtgggc tggatgcaga gaccctgctc       60

aagggccgag gtgtccacgg tagcttcctg gctcggccca gtcgcaagaa ccagggtgac      120

ttctcgctct ccgtcagggt gggggatcag gtgacccata ttcggatcca gaactcaggg      180

gatttctatg acctgtatgg aggggagaag tttgcgactc tgacagagct ggtggagtac      240

tacactcagc agcagggtgt cctgcaggac cgcgacggca ccatcatcca cctcaagtac      300

ccgctgaact gctccgatcc cactagtgag aggtggtacc atggccacat gtctggcggg      360

caggcagaga cgctgctgca ggccaagggc gagccctgga cgtttcttgt gcgtgagagc      420

ctcagccagc ctggagactt cgtgctttct gtgctcagtg accagcccaa ggctggccca      480

ggctccccgc tcagggtcac ccacatcaag gtcatgtgcg agggtggacg ctacacagtg      540

ggtggtttgg agaccttcga cagcctcacg gacctggtgg agcatttcaa gaagacgggg      600

attgaggagg cctcaggcgc ctttgtctac ctgcggcagc cgtactatgc cacgagggtg      660

aatgcggctg acattgagaa ccgagtgttg gaactgaaca agaagcagga gtccgaggat      720

acagccaagg ctggcttctg ggaggagttt gagagtttgc agaagcagga ggtgaagaac      780

ttgcaccagc gtctggaagg gcagcggcca gagaacaagg gcaagaaccg ctacaagaac      840

attctcccct ttgaccacag ccgagtgatc ctgcagggac gggacagtaa catccccggg      900

tccgactaca tcaatgccaa ctacatcaag aaccagctgc taggccctga tgagaacgct      960

aagacctaca tcgccagcca gggctgtctg gaggccacgg tcaatgactt ctggcagatg     1020

gcgtggcagg agaacagccg tgtcatcgtc atgaccaccc gagaggtgga gaaaggccgg     1080

aacaaatgcg tcccatactg gcccgaggtg ggcatgcagc gtgcttatgg gccctactct     1140

gtgaccaact gcggggagca tgacacaacc gaatacaaac tccgtacctt acaggtctcc     1200

ccgctggaca atggagacct gattcgggag atctggcatt accagtacct gagctggccc     1260

gaccatgggg tccccagtga gcctgggggt gtcctcagct tcctggacca gatcaaccag     1320

cggcaggaaa gtctgcctca cgcagggccc atcatcgtgc actgcagcgc cggcatcggc     1380

cgcacaggca ccatcattgt catcgacatg ctcatggaga acatctccac caagggcctg     1440

gactgtgaca ttgacatcca gaagaccatc cagatggtgc gggcgcagcg ctcgggcatg     1500

gtgcagacgg aggcgcagta caagttcatc tacgtggcca tcgcccagtt cattgaaacc     1560

actaagaaga agctggaggt cctgcagtcg cagaagggcc aggagtcgga gtacgggaac     1620

atcacctatc ccccagccat gaagaatgcc catgccaagg cctcccgcac ctcgtccaaa     1680

cacaaggagg atgtgtatga gaacctgcac actaagaaca agagggagga gaaagtgaag     1740

aagcagcggt cagcagacaa ggagaagagc aagggttccc tcaagaggaa gtga           1794


<210>  24
<211>  1875
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  PTPN6 transcript variant 3, cDNA, NM_080549.3

<400>  24
atggtgaggt ggtttcaccg agacctcagt gggctggatg cagagaccct gctcaagggc       60

cgaggtgtcc acggtagctt cctggctcgg cccagtcgca agaaccaggg tgacttctcg      120

ctctccgtca gggtggggga tcaggtgacc catattcgga tccagaactc aggggatttc      180

tatgacctgt atggagggga gaagtttgcg actctgacag agctggtgga gtactacact      240

cagcagcagg gtgtcctgca ggaccgcgac ggcaccatca tccacctcaa gtacccgctg      300

aactgctccg atcccactag tgagaggtgg taccatggcc acatgtctgg cgggcaggca      360

gagacgctgc tgcaggccaa gggcgagccc tggacgtttc ttgtgcgtga gagcctcagc      420

cagcctggag acttcgtgct ttctgtgctc agtgaccagc ccaaggctgg cccaggctcc      480

ccgctcaggg tcacccacat caaggtcatg tgcgagggtg gacgctacac agtgggtggt      540

ttggagacct tcgacagcct cacggacctg gtggagcatt tcaagaagac ggggattgag      600

gaggcctcag gcgcctttgt ctacctgcgg cagccgtact atgccacgag ggtgaatgcg      660

gctgacattg agaaccgagt gttggaactg aacaagaagc aggagtccga ggatacagcc      720

aaggctggct tctgggagga gtttgagagt ttgcagaagc aggaggtgaa gaacttgcac      780

cagcgtctgg aagggcagcg gccagagaac aagggcaaga accgctacaa gaacattctc      840

ccctttgacc acagccgagt gatcctgcag ggacgggaca gtaacatccc cgggtccgac      900

tacatcaatg ccaactacat caagaaccag ctgctaggcc ctgatgagaa cgctaagacc      960

tacatcgcca gccagggctg tctggaggcc acggtcaatg acttctggca gatggcgtgg     1020

caggagaaca gccgtgtcat cgtcatgacc acccgagagg tggagaaagg ccggaacaaa     1080

tgcgtcccat actggcccga ggtgggcatg cagcgtgctt atgggcccta ctctgtgacc     1140

aactgcgggg agcatgacac aaccgaatac aaactccgta ccttacaggt ctccccgctg     1200

gacaatggag acctgattcg ggagatctgg cattaccagt acctgagctg gcccgaccat     1260

ggggtcccca gtgagcctgg gggtgtcctc agcttcctgg accagatcaa ccagcggcag     1320

gaaagtctgc ctcacgcagg gcccatcatc gtgcactgca gcgccggcat cggccgcaca     1380

ggcaccatca ttgtcatcga catgctcatg gagaacatct ccaccaaggg cctggactgt     1440

gacattgaca tccagaagac catccagatg gtgcgggcgc agcgctcggg catggtgcag     1500

acggaggcgc agtacaagtt catctacgtg gccatcgccc agttcattga aaccactaag     1560

aagaagctgg aggtcctgca gtcgcagaag ggccaggagt cggagtacgg gaacatcacc     1620

tatcccccag ccatgaagaa tgcccatgcc aaggcctccc gcacctcgtc caagagcttg     1680

gagtctagtg cagggaccgt ggctgcgtca cctgtgagac ggggtggcca gaggggactg     1740

ccagtgccgg gtccccctgt gctgtctcct gacctgcacc aactgcctgt acttgccccc     1800

ctgcacccgg ctgcagacac aaggaggatg tgtatgagaa cctgcacact aagaacaaga     1860

gggaggagaa agtga                                                      1875


<210>  25
<211>  597
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  tyrosine-protein phosphatase non-receptor type 6 isoform 2, 
       NP_536858.1

<400>  25

Met Leu Ser Arg Gly Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala 
1               5                   10                  15      


Glu Thr Leu Leu Lys Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg 
            20                  25                  30          


Pro Ser Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly 
        35                  40                  45              


Asp Gln Val Thr His Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp 
    50                  55                  60                  


Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr 
65                  70                  75                  80  


Tyr Thr Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile 
                85                  90                  95      


His Leu Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Ser Glu Arg Trp 
            100                 105                 110         


Tyr His Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala 
        115                 120                 125             


Lys Gly Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro 
    130                 135                 140                 


Gly Asp Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro 
145                 150                 155                 160 


Gly Ser Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly Gly 
                165                 170                 175     


Arg Tyr Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp Leu 
            180                 185                 190         


Val Glu His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe 
        195                 200                 205             


Val Tyr Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val Asn Ala Ala Asp 
    210                 215                 220                 


Ile Glu Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Glu Ser Glu Asp 
225                 230                 235                 240 


Thr Ala Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln 
                245                 250                 255     


Glu Val Lys Asn Leu His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn 
            260                 265                 270         


Lys Gly Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg 
        275                 280                 285             


Val Ile Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile 
    290                 295                 300                 


Asn Ala Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala 
305                 310                 315                 320 


Lys Thr Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp 
                325                 330                 335     


Phe Trp Gln Met Ala Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr 
            340                 345                 350         


Thr Arg Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro 
        355                 360                 365             


Glu Val Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys 
    370                 375                 380                 


Gly Glu His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser 
385                 390                 395                 400 


Pro Leu Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr 
                405                 410                 415     


Leu Ser Trp Pro Asp His Gly Val Pro Ser Glu Pro Gly Gly Val Leu 
            420                 425                 430         


Ser Phe Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala 
        435                 440                 445             


Gly Pro Ile Ile Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr 
    450                 455                 460                 


Ile Ile Val Ile Asp Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu 
465                 470                 475                 480 


Asp Cys Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln 
                485                 490                 495     


Arg Ser Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val 
            500                 505                 510         


Ala Ile Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Leu Glu Val Leu 
        515                 520                 525             


Gln Ser Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Ile Thr Tyr Pro 
    530                 535                 540                 


Pro Ala Met Lys Asn Ala His Ala Lys Ala Ser Arg Thr Ser Ser Lys 
545                 550                 555                 560 


His Lys Glu Asp Val Tyr Glu Asn Leu His Thr Lys Asn Lys Arg Glu 
                565                 570                 575     


Glu Lys Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Lys Ser Lys Gly 
            580                 585                 590         


Ser Leu Lys Arg Lys 
        595         


<210>  26
<211>  624
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  tyrosine-protein phosphatase non-receptor type 6 isoform 3, 
       NP_536859.1

<400>  26

Met Val Arg Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala Glu Thr 
1               5                   10                  15      


Leu Leu Lys Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg Pro Ser 
            20                  25                  30          


Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly Asp Gln 
        35                  40                  45              


Val Thr His Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp Leu Tyr 
    50                  55                  60                  


Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr Tyr Thr 
65                  70                  75                  80  


Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile His Leu 
                85                  90                  95      


Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Ser Glu Arg Trp Tyr His 
            100                 105                 110         


Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala Lys Gly 
        115                 120                 125             


Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro Gly Asp 
    130                 135                 140                 


Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro Gly Ser 
145                 150                 155                 160 


Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly Gly Arg Tyr 
                165                 170                 175     


Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp Leu Val Glu 
            180                 185                 190         


His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe Val Tyr 
        195                 200                 205             


Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val Asn Ala Ala Asp Ile Glu 
    210                 215                 220                 


Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Glu Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val 
                245                 250                 255     


Lys Asn Leu His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly 
            260                 265                 270         


Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile 
        275                 280                 285             


Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala 
    290                 295                 300                 


Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr 
305                 310                 315                 320 


Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp 
                325                 330                 335     


Gln Met Ala Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg 
            340                 345                 350         


Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val 
        355                 360                 365             


Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu 
    370                 375                 380                 


His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu 
385                 390                 395                 400 


Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser 
                405                 410                 415     


Trp Pro Asp His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe 
            420                 425                 430         


Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro 
        435                 440                 445             


Ile Ile Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile 
    450                 455                 460                 


Val Ile Asp Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys 
465                 470                 475                 480 


Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser 
                485                 490                 495     


Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile 
            500                 505                 510         


Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Leu Glu Val Leu Gln Ser 
        515                 520                 525             


Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Ile Thr Tyr Pro Pro Ala 
    530                 535                 540                 


Met Lys Asn Ala His Ala Lys Ala Ser Arg Thr Ser Ser Lys Ser Leu 
545                 550                 555                 560 


Glu Ser Ser Ala Gly Thr Val Ala Ala Ser Pro Val Arg Arg Gly Gly 
                565                 570                 575     


Gln Arg Gly Leu Pro Val Pro Gly Pro Pro Val Leu Ser Pro Asp Leu 
            580                 585                 590         


His Gln Leu Pro Val Leu Ala Pro Leu His Pro Ala Ala Asp Thr Arg 
        595                 600                 605             


Arg Met Cys Met Arg Thr Cys Thr Leu Arg Thr Arg Gly Arg Arg Lys 
    610                 615                 620                 


<210>  27
<211>  1782
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  PTPN11, transcript variant 1 cDNA, NM_002834.4

<400>  27
atgacatcgc ggagatggtt tcacccaaat atcactggtg tggaggcaga aaacctactg       60

ttgacaagag gagttgatgg cagttttttg gcaaggccta gtaaaagtaa ccctggagac      120

ttcacacttt ccgttagaag aaatggagct gtcacccaca tcaagattca gaacactggt      180

gattactatg acctgtatgg aggggagaaa tttgccactt tggctgagtt ggtccagtat      240

tacatggaac atcacgggca attaaaagag aagaatggag atgtcattga gcttaaatat      300

cctctgaact gtgcagatcc tacctctgaa aggtggtttc atggacatct ctctgggaaa      360

gaagcagaga aattattaac tgaaaaagga aaacatggta gttttcttgt acgagagagc      420

cagagccacc ctggagattt tgttctttct gtgcgcactg gtgatgacaa aggggagagc      480

aatgacggca agtctaaagt gacccatgtt atgattcgct gtcaggaact gaaatacgac      540

gttggtggag gagaacggtt tgattctttg acagatcttg tggaacatta taagaagaat      600

cctatggtgg aaacattggg tacagtacta caactcaagc agccccttaa cacgactcgt      660

ataaatgctg ctgaaataga aagcagagtt cgagaactaa gcaaattagc tgagaccaca      720

gataaagtca aacaaggctt ttgggaagaa tttgagacac tacaacaaca ggagtgcaaa      780

cttctctaca gccgaaaaga gggtcaaagg caagaaaaca aaaacaaaaa tagatataaa      840

aacatcctgc cctttgatca taccagggtt gtcctacacg atggtgatcc caatgagcct      900

gtttcagatt acatcaatgc aaatatcatc atgcctgaat ttgaaaccaa gtgcaacaat      960

tcaaagccca aaaagagtta cattgccaca caaggctgcc tgcaaaacac ggtgaatgac     1020

ttttggcgga tggtgttcca agaaaactcc cgagtgattg tcatgacaac gaaagaagtg     1080

gagagaggaa agagtaaatg tgtcaaatac tggcctgatg agtatgctct aaaagaatat     1140

ggcgtcatgc gtgttaggaa cgtcaaagaa agcgccgctc atgactatac gctaagagaa     1200

cttaaacttt caaaggttgg acaagggaat acggagagaa cggtctggca ataccacttt     1260

cggacctggc cggaccacgg cgtgcccagc gaccctgggg gcgtgctgga cttcctggag     1320

gaggtgcacc ataagcagga gagcatcatg gatgcagggc cggtcgtggt gcactgcagt     1380

gctggaattg gccggacagg gacgttcatt gtgattgata ttcttattga catcatcaga     1440

gagaaaggtg ttgactgcga tattgacgtt cccaaaacca tccagatggt gcggtctcag     1500

aggtcaggga tggtccagac agaagcacag taccgattta tctatatggc ggtccagcat     1560

tatattgaaa cactacagcg caggattgaa gaagagcaga aaagcaagag gaaagggcac     1620

gaatatacaa atattaagta ttctctagcg gaccagacga gtggagatca gagccctctc     1680

ccgccttgta ctccaacgcc accctgtgca gaaatgagag aagacagtgc tagagtctat     1740

gaaaacgtgg gcctgatgca acagcagaaa agtttcagat ga                        1782


<210>  28
<211>  1383
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  PTPN11 transcript variant 2, cDNA, NM_080601.2

<400>  28
atgacatcgc ggagatggtt tcacccaaat atcactggtg tggaggcaga aaacctactg       60

ttgacaagag gagttgatgg cagttttttg gcaaggccta gtaaaagtaa ccctggagac      120

ttcacacttt ccgttagaag aaatggagct gtcacccaca tcaagattca gaacactggt      180

gattactatg acctgtatgg aggggagaaa tttgccactt tggctgagtt ggtccagtat      240

tacatggaac atcacgggca attaaaagag aagaatggag atgtcattga gcttaaatat      300

cctctgaact gtgcagatcc tacctctgaa aggtggtttc atggacatct ctctgggaaa      360

gaagcagaga aattattaac tgaaaaagga aaacatggta gttttcttgt acgagagagc      420

cagagccacc ctggagattt tgttctttct gtgcgcactg gtgatgacaa aggggagagc      480

aatgacggca agtctaaagt gacccatgtt atgattcgct gtcaggaact gaaatacgac      540

gttggtggag gagaacggtt tgattctttg acagatcttg tggaacatta taagaagaat      600

cctatggtgg aaacattggg tacagtacta caactcaagc agccccttaa cacgactcgt      660

ataaatgctg ctgaaataga aagcagagtt cgagaactaa gcaaattagc tgagaccaca      720

gataaagtca aacaaggctt ttgggaagaa tttgagacac tacaacaaca ggagtgcaaa      780

cttctctaca gccgaaaaga gggtcaaagg caagaaaaca aaaacaaaaa tagatataaa      840

aacatcctgc cctttgatca taccagggtt gtcctacacg atggtgatcc caatgagcct      900

gtttcagatt acatcaatgc aaatatcatc atgcctgaat ttgaaaccaa gtgcaacaat      960

tcaaagccca aaaagagtta cattgccaca caaggctgcc tgcaaaacac ggtgaatgac     1020

ttttggcgga tggtgttcca agaaaactcc cgagtgattg tcatgacaac gaaagaagtg     1080

gagagaggaa agagtaaatg tgtcaaatac tggcctgatg agtatgctct aaaagaatat     1140

ggcgtcatgc gtgttaggaa cgtcaaagaa agcgccgctc atgactatac gctaagagaa     1200

cttaaacttt caaaggttgg acaagggaat acggagagaa cggtctggca ataccacttt     1260

cggacctggc cggaccacgg cgtgcccagc gaccctgggg gcgtgctgga cttcctggag     1320

gaggtgcacc ataagcagga gagcatcatg gatgcagggc cggtcgtggt gcactgcagg     1380

tga                                                                   1383


<210>  29
<211>  593
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  tyrosine-protein phosphatase non-receptor type 11 isoform 1, 
       NP_002825.3

<400>  29

Met Thr Ser Arg Arg Trp Phe His Pro Asn Ile Thr Gly Val Glu Ala 
1               5                   10                  15      


Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gly Ser Phe Leu Ala Arg 
            20                  25                  30          


Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Leu Ser Val Arg Arg Asn 
        35                  40                  45              


Gly Ala Val Thr His Ile Lys Ile Gln Asn Thr Gly Asp Tyr Tyr Asp 
    50                  55                  60                  


Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Ala Glu Leu Val Gln Tyr 
65                  70                  75                  80  


Tyr Met Glu His His Gly Gln Leu Lys Glu Lys Asn Gly Asp Val Ile 
                85                  90                  95      


Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pro Thr Ser Glu Arg Trp 
            100                 105                 110         


Phe His Gly His Leu Ser Gly Lys Glu Ala Glu Lys Leu Leu Thr Glu 
        115                 120                 125             


Lys Gly Lys His Gly Ser Phe Leu Val Arg Glu Ser Gln Ser His Pro 
    130                 135                 140                 


Gly Asp Phe Val Leu Ser Val Arg Thr Gly Asp Asp Lys Gly Glu Ser 
145                 150                 155                 160 


Asn Asp Gly Lys Ser Lys Val Thr His Val Met Ile Arg Cys Gln Glu 
                165                 170                 175     


Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Phe Asp Ser Leu Thr Asp 
            180                 185                 190         


Leu Val Glu His Tyr Lys Lys Asn Pro Met Val Glu Thr Leu Gly Thr 
        195                 200                 205             


Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Thr Arg Ile Asn Ala Ala 
    210                 215                 220                 


Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Lys Leu Ala Glu Thr Thr 
225                 230                 235                 240 


Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Phe Glu Thr Leu Gln Gln 
                245                 250                 255     


Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Glu Gly Gln Arg Gln Glu 
            260                 265                 270         


Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Thr 
        275                 280                 285             


Arg Val Val Leu His Asp Gly Asp Pro Asn Glu Pro Val Ser Asp Tyr 
    290                 295                 300                 


Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Glu Thr Lys Cys Asn Asn 
305                 310                 315                 320 


Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gln Gly Cys Leu Gln Asn 
                325                 330                 335     


Thr Val Asn Asp Phe Trp Arg Met Val Phe Gln Glu Asn Ser Arg Val 
            340                 345                 350         


Ile Val Met Thr Thr Lys Glu Val Glu Arg Gly Lys Ser Lys Cys Val 
        355                 360                 365             


Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Glu Tyr Gly Val Met Arg 
    370                 375                 380                 


Val Arg Asn Val Lys Glu Ser Ala Ala His Asp Tyr Thr Leu Arg Glu 
385                 390                 395                 400 


Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Thr Glu Arg Thr Val Trp 
                405                 410                 415     


Gln Tyr His Phe Arg Thr Trp Pro Asp His Gly Val Pro Ser Asp Pro 
            420                 425                 430         


Gly Gly Val Leu Asp Phe Leu Glu Glu Val His His Lys Gln Glu Ser 
        435                 440                 445             


Ile Met Asp Ala Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly 
    450                 455                 460                 


Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Leu Ile Asp Ile Ile Arg 
465                 470                 475                 480 


Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pro Lys Thr Ile Gln Met 
                485                 490                 495     


Val Arg Ser Gln Arg Ser Gly Met Val Gln Thr Glu Ala Gln Tyr Arg 
            500                 505                 510         


Phe Ile Tyr Met Ala Val Gln His Tyr Ile Glu Thr Leu Gln Arg Arg 
        515                 520                 525             


Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gly His Glu Tyr Thr Asn 
    530                 535                 540                 


Ile Lys Tyr Ser Leu Ala Asp Gln Thr Ser Gly Asp Gln Ser Pro Leu 
545                 550                 555                 560 


Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Glu Met Arg Glu Asp Ser 
                565                 570                 575     


Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gln Gln Gln Lys Ser Phe 
            580                 585                 590         


Arg 
    


<210>  30
<211>  460
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  tyrosine-protein phosphatase non-receptor type 11 isoform 2, 
       NP_542168.1

<400>  30

Met Thr Ser Arg Arg Trp Phe His Pro Asn Ile Thr Gly Val Glu Ala 
1               5                   10                  15      


Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gly Ser Phe Leu Ala Arg 
            20                  25                  30          


Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Leu Ser Val Arg Arg Asn 
        35                  40                  45              


Gly Ala Val Thr His Ile Lys Ile Gln Asn Thr Gly Asp Tyr Tyr Asp 
    50                  55                  60                  


Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Ala Glu Leu Val Gln Tyr 
65                  70                  75                  80  


Tyr Met Glu His His Gly Gln Leu Lys Glu Lys Asn Gly Asp Val Ile 
                85                  90                  95      


Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pro Thr Ser Glu Arg Trp 
            100                 105                 110         


Phe His Gly His Leu Ser Gly Lys Glu Ala Glu Lys Leu Leu Thr Glu 
        115                 120                 125             


Lys Gly Lys His Gly Ser Phe Leu Val Arg Glu Ser Gln Ser His Pro 
    130                 135                 140                 


Gly Asp Phe Val Leu Ser Val Arg Thr Gly Asp Asp Lys Gly Glu Ser 
145                 150                 155                 160 


Asn Asp Gly Lys Ser Lys Val Thr His Val Met Ile Arg Cys Gln Glu 
                165                 170                 175     


Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Phe Asp Ser Leu Thr Asp 
            180                 185                 190         


Leu Val Glu His Tyr Lys Lys Asn Pro Met Val Glu Thr Leu Gly Thr 
        195                 200                 205             


Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Thr Arg Ile Asn Ala Ala 
    210                 215                 220                 


Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Lys Leu Ala Glu Thr Thr 
225                 230                 235                 240 


Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Phe Glu Thr Leu Gln Gln 
                245                 250                 255     


Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Glu Gly Gln Arg Gln Glu 
            260                 265                 270         


Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Thr 
        275                 280                 285             


Arg Val Val Leu His Asp Gly Asp Pro Asn Glu Pro Val Ser Asp Tyr 
    290                 295                 300                 


Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Glu Thr Lys Cys Asn Asn 
305                 310                 315                 320 


Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gln Gly Cys Leu Gln Asn 
                325                 330                 335     


Thr Val Asn Asp Phe Trp Arg Met Val Phe Gln Glu Asn Ser Arg Val 
            340                 345                 350         


Ile Val Met Thr Thr Lys Glu Val Glu Arg Gly Lys Ser Lys Cys Val 
        355                 360                 365             


Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Glu Tyr Gly Val Met Arg 
    370                 375                 380                 


Val Arg Asn Val Lys Glu Ser Ala Ala His Asp Tyr Thr Leu Arg Glu 
385                 390                 395                 400 


Leu Lys Leu Ser Lys Val Gly Gln Gly Asn Thr Glu Arg Thr Val Trp 
                405                 410                 415     


Gln Tyr His Phe Arg Thr Trp Pro Asp His Gly Val Pro Ser Asp Pro 
            420                 425                 430         


Gly Gly Val Leu Asp Phe Leu Glu Glu Val His His Lys Gln Glu Ser 
        435                 440                 445             


Ile Met Asp Ala Gly Pro Val Val Val His Cys Arg 
    450                 455                 460 


