                         SEQUENCE LISTING

<110>  Numab Therapeutics AG
 
<120>  MULTISPECIFIC ANTIBODIES HAVING SPECIFICITY FOR TNFa AND IL-17A, 
       ANTIBODIES TARGETING IL-17A, AND METHODS OF USE THEREOF

<130>  115527P877PC

<150>  EP19154852.8
<151>  2019-01-31

<150>  EP19154846.0
<151>  2019-01-31

<150>  EP19154850.2
<151>  2019-01-31

<160>  149   

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  1

Gly Phe Ser Phe Ser Ser Asp Tyr Trp Met Cys 
1               5                   10      


<210>  2
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  2

Cys Ile Tyr Ala Gly Asp Val Asp Asp Thr Asp Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Arg Gly 
        


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  3

Arg Val Asp Gly Phe Asp Ile Thr Tyr Phe Asp Leu 
1               5                   10          


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  4

Ser Asp Tyr Trp Met Cys 
1               5       


<210>  5
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  5

Cys Ile Tyr Ala Gly Asp Val Asp Asp Thr Asp Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Arg Gly 
        


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  6

Val Asp Gly Phe Asp Ile Thr Tyr Phe Asp Leu 
1               5                   10      


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  7

Gly Phe Ser Phe Ser Ser Asp Tyr 
1               5               


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  8

Ala Gly Asp Val Asp 
1               5   


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  9

Asp Gly Phe Asp Ile Thr Tyr Phe Asp 
1               5                   


<210>  10
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Asp 
            20                  25                  30          


Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Ala Gly Asp Val Asp Asp Thr Asp Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Val Asp Gly Phe Asp Ile Thr Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  11
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Glu Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Asp 
            20                  25                  30          


Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Ala Gly Asp Val Asp Asp Thr Asp Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Val Asp Gly Phe Asp Ile Thr Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  12

Gln Ala Ser Gln Thr Ile Asn Tyr Trp Leu Ala 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  13

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  14

Gln Asn Tyr Tyr Tyr Ser Thr Ser Arg Ser Tyr Gly 
1               5                   10          


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  15

Gln Ala Ser Gln Thr Ile Asn Tyr Trp Leu Ala 
1               5                   10      


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  16

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  17

Gln Asn Tyr Tyr Tyr Ser Thr Ser Arg Ser Tyr Gly 
1               5                   10          


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  18

Ser Gln Thr Ile Asn Tyr Trp 
1               5           


<210>  19
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  19

Arg Ala Ser 
1           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  20

Tyr Tyr Tyr Ser Thr Ser Arg Ser Tyr 
1               5                   


<210>  21
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Thr Ile Asn Tyr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Tyr Ser Thr Ser 
                85                  90                  95      


Arg Ser Tyr Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  22
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Thr Ile Asn Tyr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Tyr Ser Thr Ser 
                85                  90                  95      


Arg Ser Tyr Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  23

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  24
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Thr Ile Asn Tyr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Tyr Ser Thr Ser 
                85                  90                  95      


Arg Ser Tyr Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe 
145                 150                 155                 160 


Ser Ser Asp Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Ile Gly Cys Ile Tyr Ala Gly Asp Val Asp Asp Thr Asp 
            180                 185                 190         


Tyr Ala Ser Trp Ala Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        195                 200                 205             


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Val Asp Gly Phe Asp Ile Thr Tyr Phe 
225                 230                 235                 240 


Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250             


<210>  25
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Thr Ile Asn Tyr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Tyr Ser Thr Ser 
                85                  90                  95      


Arg Ser Tyr Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
    130                 135                 140                 


Pro Glu Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe 
145                 150                 155                 160 


Ser Ser Asp Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Ile Ala Cys Ile Tyr Ala Gly Asp Val Asp Asp Thr Asp 
            180                 185                 190         


Tyr Ala Ser Trp Ala Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        195                 200                 205             


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Val Asp Gly Phe Asp Ile Thr Tyr Phe 
225                 230                 235                 240 


Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250             


<210>  26
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  26

Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
1               5                   10      


<210>  27
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  27

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
1               5                   10      


<210>  28
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  28

Phe Gly Gly Gly Thr Gln Leu Ile Ile Leu Gly 
1               5                   10      


<210>  29
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  29

Phe Gly Glu Gly Thr Glu Leu Thr Val Leu Gly 
1               5                   10      


<210>  30
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  30

Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly 
1               5                   10      


<210>  31
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  31

Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
1               5                   10      


<210>  32
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  32

Phe Gly Gly Gly Thr Gln Leu Thr Ala Leu Gly 
1               5                   10      


<210>  33
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Ala Ile Pro Gln Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Val Asn Ala Asp Gly Lys Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ser 
145                 150                 155 


<210>  34
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Asp Trp Pro His Asn Leu Leu Phe Leu Leu Thr Ile Ser Ile Phe 
1               5                   10                  15      


Leu Gly Leu Gly Gln Pro Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln 
            20                  25                  30          


Gly Arg Pro Gly Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp 
        35                  40                  45              


Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg 
    50                  55                  60                  


Asn Ile Glu Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala 
65                  70                  75                  80  


Gln Arg Lys Cys Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg 
                85                  90                  95      


Ser Leu Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile 
            100                 105                 110         


Pro Val Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn 
        115                 120                 125             


Pro Phe Thr Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe 
    130                 135                 140                 


Ser Gln Val Pro Val Arg Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr 
145                 150                 155                 160 


Gly Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys 
                165                 170                 175     


Thr Cys Ile Phe 
            180 


<210>  35
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Thr Leu Leu Pro Gly Leu Leu Phe Leu Thr Trp Leu His Thr Cys 
1               5                   10                  15      


Leu Ala His His Asp Pro Ser Leu Arg Gly His Pro His Ser His Gly 
            20                  25                  30          


Thr Pro His Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Ala Pro 
        35                  40                  45              


Pro His Leu Leu Ala Arg Gly Ala Lys Trp Gly Gln Ala Leu Pro Val 
    50                  55                  60                  


Ala Leu Val Ser Ser Leu Glu Ala Ala Ser His Arg Gly Arg His Glu 
65                  70                  75                  80  


Arg Pro Ser Ala Thr Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val 
                85                  90                  95      


Leu Glu Ala Asp Thr His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg 
            100                 105                 110         


Val Asp Thr Asp Glu Asp Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu 
        115                 120                 125             


Cys Leu Cys Arg Gly Cys Ile Asp Ala Arg Thr Gly Arg Glu Thr Ala 
    130                 135                 140                 


Ala Leu Asn Ser Val Arg Leu Leu Gln Ser Leu Leu Val Leu Arg Arg 
145                 150                 155                 160 


Arg Pro Cys Ser Arg Asp Gly Ser Gly Leu Pro Thr Pro Gly Ala Phe 
                165                 170                 175     


Ala Phe His Thr Glu Phe Ile His Val Pro Val Gly Cys Thr Cys Val 
            180                 185                 190         


Leu Pro Arg Ser Val 
        195         


<210>  36
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Leu Val Ala Gly Phe Leu Leu Ala Leu Pro Pro Ser Trp Ala Ala 
1               5                   10                  15      


Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala 
            20                  25                  30          


Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala 
        35                  40                  45              


Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu 
    50                  55                  60                  


Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp Arg 
65                  70                  75                  80  


Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr 
                85                  90                  95      


Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu Ala 
            100                 105                 110         


Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp 
        115                 120                 125             


Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu Arg 
    130                 135                 140                 


Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala Tyr 
145                 150                 155                 160 


Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys Asp 
                165                 170                 175     


Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu Leu 
            180                 185                 190         


Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro 
        195                 200         


<210>  37
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Arg Glu Arg Pro Arg Leu Gly Glu Asp Ser Ser Leu Ile Ser Leu 
1               5                   10                  15      


Phe Leu Gln Val Val Ala Phe Leu Ala Met Val Met Gly Thr His Thr 
            20                  25                  30          


Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln Asp Thr Ser 
        35                  40                  45              


Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro Leu Glu Pro 
    50                  55                  60                  


Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser Glu Asp Gly 
65                  70                  75                  80  


Pro Leu Asn Ser Arg Ala Ile Ser Pro Trp Arg Tyr Glu Leu Asp Arg 
                85                  90                  95      


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
            100                 105                 110         


Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Arg Gly 
        115                 120                 125             


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
    130                 135                 140                 


Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu Glu Arg Arg 
145                 150                 155                 160 


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
                165                 170                 175     


Gly 
    


<210>  38
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Thr Val Lys Thr Leu His Gly Pro Ala Met Val Lys Tyr Leu Leu 
1               5                   10                  15      


Leu Ser Ile Leu Gly Leu Ala Phe Leu Ser Glu Ala Ala Ala Arg Lys 
            20                  25                  30          


Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser Cys Pro 
        35                  40                  45              


Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile Asn Glu 
    50                  55                  60                  


Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser Thr Ser 
65                  70                  75                  80  


Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro Ser Glu 
                85                  90                  95      


Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala Gln Gly 
            100                 105                 110         


Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu Thr Leu 
        115                 120                 125             


Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln Leu Glu 
    130                 135                 140                 


Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val Ile His 
145                 150                 155                 160 


His Val Gln 
            


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  39

Gly Phe Ser Phe Ser Gly Phe Tyr Tyr Met Cys 
1               5                   10      


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  40

Cys Ile Asp Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  41

Arg Asp Ala Ala Tyr Gly Gly Tyr Ala Tyr Pro Ala His Gly Met Asp 
1               5                   10                  15      


Leu 
    


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  42

Gly Phe Tyr Tyr Met Cys 
1               5       


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  43

Cys Ile Asp Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  44

Asp Ala Ala Tyr Gly Gly Tyr Ala Tyr Pro Ala His Gly Met Asp Leu 
1               5                   10                  15      


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  45

Gly Phe Ser Phe Ser Gly Phe Tyr 
1               5               


<210>  46
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  46

Thr Gly Asp Gly 
1               


<210>  47
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  47

Ala Ala Tyr Gly Gly Tyr Ala Tyr Pro Ala His Gly Met Asp 
1               5                   10                  


<210>  48
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Phe 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Asp Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ala Ala Tyr Gly Gly Tyr Ala Tyr Pro Ala His Gly 
            100                 105                 110         


Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  49
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Phe 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Asp Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ala Ala Tyr Gly Gly Tyr Ala Tyr Pro Ala His Gly 
            100                 105                 110         


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  50

Gln Ala Ser Glu Ser Ile Tyr Arg Tyr Leu Ser 
1               5                   10      


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  51

Leu Ala Ser Thr Leu Thr Ser 
1               5           


<210>  52
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  52

Gln Ser Asn Phe Gly Thr Ala Ser Thr Thr Tyr Tyr Asn Thr 
1               5                   10                  


<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  53

Gln Ala Ser Glu Ser Ile Tyr Arg Tyr Leu Ser 
1               5                   10      


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  54

Leu Ala Ser Thr Leu Thr Ser 
1               5           


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  55

Gln Ser Asn Phe Gly Thr Ala Ser Thr Thr Tyr Tyr Asn Thr 
1               5                   10                  


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  56

Ser Glu Ser Ile Tyr Arg Tyr 
1               5           


<210>  57
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  57

Leu Ala Ser 
1           


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  58

Asn Phe Gly Thr Ala Ser Thr Thr Tyr Tyr Asn 
1               5                   10      


<210>  59
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Tyr Arg Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Thr Tyr Tyr Asn Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly 
    


<210>  60
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Tyr Arg Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Thr Tyr Tyr Asn Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly 
    


<210>  61
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Tyr Arg Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Thr Tyr Tyr Asn Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Ser Phe Ser Gly Phe Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Ile Gly Cys Ile Asp Thr Gly Asp Gly Thr Thr 
            180                 185                 190         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Gly Gly Tyr Ala 
225                 230                 235                 240 


Tyr Pro Ala His Gly Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  62
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Tyr Arg Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Thr Leu Thr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Asn Phe Gly Thr Ala Ser 
                85                  90                  95      


Thr Thr Tyr Tyr Asn Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Ser Phe Ser Gly Phe Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Ile Gly Cys Ile Asp Thr Gly Asp Gly Thr Thr 
            180                 185                 190         


Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Gly Gly Tyr Ala 
225                 230                 235                 240 


Tyr Pro Ala His Gly Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  63

Gly Ile Asp Phe Ser Thr Tyr Gly Ile Ser 
1               5                   10  


<210>  64
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  64

Tyr Ile Tyr Pro Asp Tyr Gly Ile Thr Asp Tyr Ala Ser Trp Val Asn 
1               5                   10                  15      


Gly 
    


<210>  65
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  65

Arg Ser Gly Ser Tyr Tyr Ser Arg Gly Trp Gly Ala His Tyr Phe Asn 
1               5                   10                  15      


Leu 
    


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  66

Thr Tyr Gly Ile Ser 
1               5   


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  67

Tyr Ile Tyr Pro Asp Tyr Gly Ile Thr Asp Tyr Ala Ser Trp Val Asn 
1               5                   10                  15      


Gly 
    


<210>  68
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  68

Ser Gly Ser Tyr Tyr Ser Arg Gly Trp Gly Ala His Tyr Phe Asn Leu 
1               5                   10                  15      


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  69

Gly Ile Asp Phe Ser Thr Tyr 
1               5           


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  70

Pro Asp Tyr Gly 
1               


<210>  71
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  71

Gly Ser Tyr Tyr Ser Arg Gly Trp Gly Ala His Tyr Phe Asn 
1               5                   10                  


<210>  72
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  72

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Thr Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Tyr Ile Tyr Pro Asp Tyr Gly Ile Thr Asp Tyr Ala Ser Trp Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Gln Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Ser Tyr Tyr Ser Arg Gly Trp Gly Ala His Tyr Phe 
            100                 105                 110         


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  73
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Thr Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Asp Tyr Gly Ile Thr Asp Tyr Ala Ser Trp Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Ser Tyr Tyr Ser Arg Gly Trp Gly Ala His Tyr Phe 
            100                 105                 110         


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  74
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Ile Asp Phe Ser Thr Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Tyr Ile Tyr Pro Asp Tyr Gly Ile Thr Asp Tyr Ala Ser Trp Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Leu Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Ser Tyr Tyr Ser Arg Gly Trp Gly Ala His Tyr Phe 
            100                 105                 110         


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  75
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Thr Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Tyr Ile Tyr Pro Asp Tyr Gly Ile Thr Asp Tyr Ala Ser Trp Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Gln Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Ser Tyr Tyr Ser Arg Gly Trp Gly Ala His Tyr Phe 
            100                 105                 110         


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  76

Gln Ala Ser Glu Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  77

Lys Ala Ser Thr Leu Ala Ser 
1               5           


<210>  78
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  78

Gln Gly Tyr Tyr Leu Asp Ser Ser Val Asp Asp Asn Val 
1               5                   10              


<210>  79
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  79

Gln Ala Ser Glu Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  80

Lys Ala Ser Thr Leu Ala Ser 
1               5           


<210>  81
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  81

Gln Gly Tyr Tyr Leu Asp Ser Ser Val Asp Asp Asn Val 
1               5                   10              


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  82

Ser Glu Ser Ile Ser Ser Trp 
1               5           


<210>  83
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  83

Lys Ala Ser 
1           


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  84

Tyr Tyr Leu Asp Ser Ser Val Asp Asp Asn 
1               5                   10  


<210>  85
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  85

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Leu Asp Ser Ser 
                85                  90                  95      


Val Asp Asp Asn Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  86
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  86

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Leu Asp Ser Ser 
                85                  90                  95      


Val Asp Asp Asn Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  87
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  87

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Ala Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Leu Asp Ser Ser 
                85                  90                  95      


Val Asp Asp Asn Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  88
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Leu Asp Ser Ser 
                85                  90                  95      


Val Asp Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


<210>  89
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  89

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Leu Asp Ser Ser 
                85                  90                  95      


Val Asp Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  90

Gly Phe Ser Leu Ser Ser Asn Ala Met Gly 
1               5                   10  


<210>  91
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  91

Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  92
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  92

Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu 
1               5                   10                  


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  93

Ser Asn Ala Met Gly 
1               5   


<210>  94
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  94

Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  95
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  95

Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu 
1               5                   10              


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  96

Gly Phe Ser Leu Ser Ser Asn 
1               5           


<210>  97
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  97

Val Gly Gly 
1           


<210>  98
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  98

Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr 
1               5                   10      


<210>  99
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  100
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  100

Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser 
1               5                   10              


<210>  101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  101

Asp Ala Ser Asp Leu Ala Ser 
1               5           


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  102

Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala 
1               5                   10      


<210>  103
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  103

Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser 
1               5                   10              


<210>  104
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  104

Asp Ala Ser Asp Leu Ala Ser 
1               5           


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  105

Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala 
1               5                   10      


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  106

Ser Glu Ser Val Tyr Ser Asn Asn Gln 
1               5                   


<210>  107
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  107

Asp Ala Ser 
1           


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  108

Gly Phe Ser Ser Ser Ser Asp Thr 
1               5               


<210>  109
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  109

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser 
                85                  90                  95      


Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  110
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  110

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser 
                85                  90                  95      


Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
145                 150                 155                 160 


Leu Ser Ser Asn Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Tyr Ile Gly Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe 
225                 230                 235                 240 


Tyr Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250             


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  111

Gly Phe Ser Phe Ser Ser Ser Tyr Trp Ile Cys 
1               5                   10      


<210>  112
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  112

Cys Val Phe Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  113
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  113

Arg Pro Val Ser Val Tyr Tyr Tyr Gly Met Asp Leu 
1               5                   10          


<210>  114
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  114

Ser Ser Tyr Trp Ile Cys 
1               5       


<210>  115
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  115

Cys Val Phe Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  116
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  116

Pro Val Ser Val Tyr Tyr Tyr Gly Met Asp Leu 
1               5                   10      


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  117

Gly Phe Ser Phe Ser Ser Ser Tyr 
1               5               


<210>  118
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  118

Thr Gly Asp Gly 
1               


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  119

Val Ser Val Tyr Tyr Tyr Gly Met Asp 
1               5                   


<210>  120
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  120

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Cys Val Phe Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Pro Val Ser Val Tyr Tyr Tyr Gly Met Asp Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  121
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  121

Gln Ala Ser Gln Ile Ile Ser Ser Arg Ser Ala 
1               5                   10      


<210>  122
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  122

Gln Ala Ser Lys Leu Ala Ser 
1               5           


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  123

Gln Cys Thr Tyr Ile Asp Ser Asn Phe Gly Ala 
1               5                   10      


<210>  124
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  124

Gln Ala Ser Gln Ile Ile Ser Ser Arg Ser Ala 
1               5                   10      


<210>  125
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  125

Gln Ala Ser Lys Leu Ala Ser 
1               5           


<210>  126
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  126

Gln Cys Thr Tyr Ile Asp Ser Asn Phe Gly Ala 
1               5                   10      


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  127

Ser Gln Ile Ile Ser Ser Arg 
1               5           


<210>  128
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  128

Gln Ala Ser 
1           


<210>  129
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  129

Thr Tyr Ile Asp Ser Asn Phe Gly 
1               5               


<210>  130
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  130

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ile Ile Ser Ser Arg 
            20                  25                  30          


Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Ile Asp Ser Asn 
                85                  90                  95      


Phe Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  131
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  131

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ile Ile Ser Ser Arg 
            20                  25                  30          


Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Cys Thr Tyr Ile Asp Ser Asn 
                85                  90                  95      


Phe Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 
145                 150                 155                 160 


Ser Ser Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Gly Cys Val Phe Thr Gly Asp Gly Thr Thr Tyr Tyr Ala 
            180                 185                 190         


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
    210                 215                 220                 


Tyr Phe Cys Ala Arg Pro Val Ser Val Tyr Tyr Tyr Gly Met Asp Leu 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  132
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  132

Gly Gly Gly Gly Ser 
1               5   


<210>  133
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence


<220>
<221>  Repeat
<222>  (1)..(1)
<223>  generic linker sequence (GmS)n [GlyXaaSerXaa in the Sequence 
       Listing], with m being selected from 2, 3 and 4

<220>
<221>  Repeat
<222>  (1)..(3)
<223>  generic linker sequence (GmS)n [GlyXaaSerXaa in the Sequence 
       Listing], with n being selected from 2, 3, 4, 5 and 6

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  133

Gly Xaa Ser Xaa 
1               


<210>  134
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  135
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  135

Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val 
1               5                   10                  15      


Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg 
            20                  25                  30          


Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu 
        35                  40                  45              


Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe 
    50                  55                  60                  


Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile 
65                  70                  75                  80  


Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala 
                85                  90                  95      


Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys 
            100                 105                 110         


Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys 
        115                 120                 125             


Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe 
    130                 135                 140                 


Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
145                 150                 155         


<210>  136
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  136

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser 
                85                  90                  95      


Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Arg Thr Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
        115                 120                 125             


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
    130                 135                 140                 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
145                 150                 155                 160 


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
                165                 170                 175     


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
            180                 185                 190         


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
        195                 200                 205             


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
225                 230                 235                 240 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala 
                245                 250                 255     


Ser Glu Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
            260                 265                 270         


Lys Arg Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly 
        275                 280                 285             


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
    290                 295                 300                 


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
305                 310                 315                 320 


Gly Tyr Tyr Leu Asp Ser Ser Val Asp Asp Asn Val Phe Gly Gly Gly 
                325                 330                 335     


Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        355                 360                 365             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    370                 375                 380                 


Cys Ala Ala Ser Gly Ile Asp Phe Ser Thr Tyr Gly Ile Ser Trp Val 
385                 390                 395                 400 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Tyr Ile Tyr Pro 
                405                 410                 415     


Asp Tyr Gly Ile Thr Asp Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr 
            420                 425                 430         


Ile Ser Leu Asp Asn Ala Gln Asn Thr Val Tyr Leu Gln Met Asn Ser 
        435                 440                 445             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Ser 
    450                 455                 460                 


Tyr Tyr Ser Arg Gly Trp Gly Ala His Tyr Phe Asn Leu Trp Gly Gln 
465                 470                 475                 480 


Gly Thr Leu Val Thr Val Ser Ser 
                485             


<210>  137
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  137

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
225                 230                 235                 240 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                245                 250                 255     


Cys Gln Ala Ser Gln Thr Ile Asn Tyr Trp Leu Ala Trp Tyr Gln Gln 
            260                 265                 270         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu 
        275                 280                 285             


Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    290                 295                 300                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
305                 310                 315                 320 


Tyr Cys Gln Asn Tyr Tyr Tyr Ser Thr Ser Arg Ser Tyr Gly Phe Gly 
                325                 330                 335     


Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        355                 360                 365             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    370                 375                 380                 


Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Asp Tyr Trp Met 
385                 390                 395                 400 


Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys 
                405                 410                 415     


Ile Tyr Ala Gly Asp Val Asp Asp Thr Asp Tyr Ala Ser Trp Ala Arg 
            420                 425                 430         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
        435                 440                 445             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    450                 455                 460                 


Arg Val Asp Gly Phe Asp Ile Thr Tyr Phe Asp Leu Trp Gly Gln Gly 
465                 470                 475                 480 


Thr Leu Val Thr Val Ser Ser 
                485         


<210>  138
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  138

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Thr Ile Asn Tyr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Tyr Ser Thr Ser 
                85                  90                  95      


Arg Ser Tyr Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Arg 
            100                 105                 110         


Thr Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
225                 230                 235                 240 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser 
                245                 250                 255     


Glu Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
            260                 265                 270         


Arg Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val 
        275                 280                 285             


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
    290                 295                 300                 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly 
305                 310                 315                 320 


Tyr Tyr Leu Asp Ser Ser Val Asp Asp Asn Val Phe Gly Gly Gly Thr 
                325                 330                 335     


Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        355                 360                 365             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    370                 375                 380                 


Ala Ala Ser Gly Ile Asp Phe Ser Thr Tyr Gly Ile Ser Trp Val Arg 
385                 390                 395                 400 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Tyr Ile Tyr Pro Asp 
                405                 410                 415     


Tyr Gly Ile Thr Asp Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Ile 
            420                 425                 430         


Ser Leu Asp Asn Ala Gln Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
        435                 440                 445             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Ser Tyr 
    450                 455                 460                 


Tyr Ser Arg Gly Trp Gly Ala His Tyr Phe Asn Leu Trp Gly Gln Gly 
465                 470                 475                 480 


Thr Leu Val Thr Val Ser Ser 
                485         


<210>  139
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  139

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Asp 
            20                  25                  30          


Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Tyr Ala Gly Asp Val Asp Asp Thr Asp Tyr Ala Ser 
    50                  55                  60                  


Trp Ala Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Val Asp Gly Phe Asp Ile Thr Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
225                 230                 235                 240 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                245                 250                 255     


Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp 
            260                 265                 270         


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala 
        275                 280                 285             


Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    290                 295                 300                 


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
305                 310                 315                 320 


Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala 
                325                 330                 335     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        355                 360                 365             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    370                 375                 380                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala 
385                 390                 395                 400 


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
                405                 410                 415     


Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
            420                 425                 430         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
        435                 440                 445             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
    450                 455                 460                 


Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln 
465                 470                 475                 480 


Gly Thr Leu Val Thr Val Ser Ser 
                485             


<210>  140
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  140

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Leu Asp Ser Ser 
                85                  90                  95      


Val Asp Asp Asn Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Arg Thr Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
        115                 120                 125             


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
    130                 135                 140                 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
145                 150                 155                 160 


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
                165                 170                 175     


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
            180                 185                 190         


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
        195                 200                 205             


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly 
    210                 215                 220                 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
225                 230                 235                 240 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser 
                245                 250                 255     


Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser Trp Tyr Gln Gln Lys 
            260                 265                 270         


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu Ala 
        275                 280                 285             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    290                 295                 300                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
305                 310                 315                 320 


Cys Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr Ala Phe Gly Gly Gly 
                325                 330                 335     


Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        355                 360                 365             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    370                 375                 380                 


Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met Gly Trp Val 
385                 390                 395                 400 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile Ile Ser Val 
                405                 410                 415     


Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile 
            420                 425                 430         


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
        435                 440                 445             


Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Arg His Gly 
    450                 455                 460                 


Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly Thr Leu Val 
465                 470                 475                 480 


Thr Val Ser Ser 
                


<210>  141
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  141

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Thr Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Tyr Ile Tyr Pro Asp Tyr Gly Ile Thr Asp Tyr Ala Ser Trp Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala Gln Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Ser Tyr Tyr Ser Arg Gly Trp Gly Ala His Tyr Phe 
            100                 105                 110         


Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
225                 230                 235                 240 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                245                 250                 255     


Val Thr Ile Thr Cys Gln Ala Ser Gln Thr Ile Asn Tyr Trp Leu Ala 
            260                 265                 270         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg 
        275                 280                 285             


Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    290                 295                 300                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
305                 310                 315                 320 


Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Tyr Ser Thr Ser Arg Ser 
                325                 330                 335     


Tyr Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
            340                 345                 350         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    370                 375                 380                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser 
385                 390                 395                 400 


Asp Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                405                 410                 415     


Trp Ile Gly Cys Ile Tyr Ala Gly Asp Val Asp Asp Thr Asp Tyr Ala 
            420                 425                 430         


Ser Trp Ala Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        435                 440                 445             


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    450                 455                 460                 


Tyr Tyr Cys Ala Arg Val Asp Gly Phe Asp Ile Thr Tyr Phe Asp Leu 
465                 470                 475                 480 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                485                 490     


<210>  142
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  142

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Thr Ile Asn Tyr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Tyr Ser Thr Ser 
                85                  90                  95      


Arg Ser Tyr Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        115                 120                 125             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser 
    130                 135                 140                 


Leu Ser Ser Asn Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly 
145                 150                 155                 160 


Leu Glu Tyr Ile Gly Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala 
                165                 170                 175     


Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
            180                 185                 190         


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr 
        195                 200                 205             


Tyr Phe Cys Ala Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe 
    210                 215                 220                 


Tyr Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
            260                 265                 270         


Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser 
        275                 280                 285             


Asn Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser 
            340                 345                 350         


Ser Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        355                 360                 365             


Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    370                 375                 380                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
385                 390                 395                 400 


Phe Ser Phe Ser Ser Asp Tyr Trp Met Cys Trp Val Arg Gln Ala Pro 
                405                 410                 415     


Gly Lys Gly Leu Glu Trp Ile Gly Cys Ile Tyr Ala Gly Asp Val Asp 
            420                 425                 430         


Asp Thr Asp Tyr Ala Ser Trp Ala Arg Gly Arg Phe Thr Ile Ser Arg 
        435                 440                 445             


Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    450                 455                 460                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Asp Gly Phe Asp Ile 
465                 470                 475                 480 


Thr Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
            500                 505                 510         


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Asn 
        515                 520                 525             


Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln 
    530                 535                 540                 


Lys Pro Gly Lys Arg Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu 
545                 550                 555                 560 


Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                565                 570                 575     


Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            580                 585                 590         


Tyr Cys Gln Gly Tyr Tyr Leu Asp Ser Ser Val Asp Asp Asn Val Phe 
        595                 600                 605             


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
625                 630                 635                 640 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                645                 650                 655     


Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Thr Tyr Gly Ile 
            660                 665                 670         


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Tyr 
        675                 680                 685             


Ile Tyr Pro Asp Tyr Gly Ile Thr Asp Tyr Ala Ser Trp Val Asn Gly 
    690                 695                 700                 


Arg Phe Thr Ile Ser Leu Asp Asn Ala Gln Asn Thr Val Tyr Leu Gln 
705                 710                 715                 720 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                725                 730                 735     


Ser Gly Ser Tyr Tyr Ser Arg Gly Trp Gly Ala His Tyr Phe Asn Leu 
            740                 745                 750         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        755                 760             


<210>  143
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  143

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Leu Asp Ser Ser 
                85                  90                  95      


Val Asp Asp Asn Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        115                 120                 125             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    130                 135                 140                 


Ser Phe Ser Ser Asp Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Ile Gly Cys Ile Tyr Ala Gly Asp Val Asp Asp 
                165                 170                 175     


Thr Asp Tyr Ala Ser Trp Ala Arg Gly Arg Phe Thr Ile Ser Arg Asp 
            180                 185                 190         


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        195                 200                 205             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Asp Gly Phe Asp Ile Thr 
    210                 215                 220                 


Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Thr Ile 
        275                 280                 285             


Asn Tyr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Tyr 
            340                 345                 350         


Ser Thr Ser Arg Ser Tyr Gly Phe Gly Gly Gly Thr Lys Leu Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    370                 375                 380                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
385                 390                 395                 400 


Gly Ile Asp Phe Ser Thr Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro 
                405                 410                 415     


Gly Lys Gly Leu Glu Trp Ile Ala Tyr Ile Tyr Pro Asp Tyr Gly Ile 
            420                 425                 430         


Thr Asp Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Ile Ser Leu Asp 
        435                 440                 445             


Asn Ala Gln Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    450                 455                 460                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Ser Tyr Tyr Ser Arg 
465                 470                 475                 480 


Gly Trp Gly Ala His Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val 
                485                 490                 495     


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
            500                 505                 510         


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
        515                 520                 525             


Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln 
    530                 535                 540                 


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
545                 550                 555                 560 


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
                565                 570                 575     


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
            580                 585                 590         


Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser 
        595                 600                 605             


Asp Thr Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                645                 650                 655     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
            660                 665                 670         


Ser Asn Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        675                 680                 685             


Tyr Ile Gly Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp 
    690                 695                 700                 


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
705                 710                 715                 720 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                725                 730                 735     


Cys Ala Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu 
            740                 745                 750         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        755                 760             


<210>  144
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  144

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser 
                85                  90                  95      


Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        115                 120                 125             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile 
    130                 135                 140                 


Asp Phe Ser Thr Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Trp Ile Ala Tyr Ile Tyr Pro Asp Tyr Gly Ile Thr Asp 
                165                 170                 175     


Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Ile Ser Leu Asp Asn Ala 
            180                 185                 190         


Gln Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
        195                 200                 205             


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Ser Tyr Tyr Ser Arg Gly Trp 
    210                 215                 220                 


Gly Ala His Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            260                 265                 270         


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser 
        275                 280                 285             


Glu Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    290                 295                 300                 


Arg Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val 
305                 310                 315                 320 


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr 
                325                 330                 335     


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly 
            340                 345                 350         


Tyr Tyr Leu Asp Ser Ser Val Asp Asp Asn Val Phe Gly Gly Gly Thr 
        355                 360                 365             


Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
    370                 375                 380                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
385                 390                 395                 400 


Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn Ala Met Gly Trp Val 
                405                 410                 415     


Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Ile Ile Ser Val 
            420                 425                 430         


Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile 
        435                 440                 445             


Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
    450                 455                 460                 


Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Arg His Gly 
465                 470                 475                 480 


Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly Gln Gly Thr Leu Val 
                485                 490                 495     


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
            500                 505                 510         


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
        515                 520                 525             


Val Thr Ile Thr Cys Gln Ala Ser Gln Thr Ile Asn Tyr Trp Leu Ala 
    530                 535                 540                 


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg 
545                 550                 555                 560 


Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
                565                 570                 575     


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
            580                 585                 590         


Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Tyr Ser Thr Ser Arg Ser 
        595                 600                 605             


Tyr Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
    610                 615                 620                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
625                 630                 635                 640 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                645                 650                 655     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser 
            660                 665                 670         


Asp Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        675                 680                 685             


Trp Ile Gly Cys Ile Tyr Ala Gly Asp Val Asp Asp Thr Asp Tyr Ala 
    690                 695                 700                 


Ser Trp Ala Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
705                 710                 715                 720 


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                725                 730                 735     


Tyr Tyr Cys Ala Arg Val Asp Gly Phe Asp Ile Thr Tyr Phe Asp Leu 
            740                 745                 750         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        755                 760             


<210>  145
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  145

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Leu Asp Ser Ser 
                85                  90                  95      


Val Asp Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        115                 120                 125             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    130                 135                 140                 


Ser Phe Ser Ser Asp Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Ile Gly Cys Ile Tyr Ala Gly Asp Val Asp Asp 
                165                 170                 175     


Thr Asp Tyr Ala Ser Trp Ala Arg Gly Arg Phe Thr Ile Ser Arg Asp 
            180                 185                 190         


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        195                 200                 205             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Asp Gly Phe Asp Ile Thr 
    210                 215                 220                 


Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Thr Ile 
        275                 280                 285             


Asn Tyr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Tyr 
            340                 345                 350         


Ser Thr Ser Arg Ser Tyr Gly Phe Gly Gly Gly Thr Lys Leu Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    370                 375                 380                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
385                 390                 395                 400 


Gly Ile Asp Phe Ser Thr Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro 
                405                 410                 415     


Gly Lys Gly Leu Glu Trp Ile Ala Tyr Ile Tyr Pro Asp Tyr Gly Ile 
            420                 425                 430         


Thr Asp Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Ile Ser Leu Asp 
        435                 440                 445             


Asn Ala Gln Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    450                 455                 460                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Ser Tyr Tyr Ser Arg 
465                 470                 475                 480 


Gly Trp Gly Ala His Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val 
                485                 490                 495     


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
            500                 505                 510         


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
        515                 520                 525             


Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln 
    530                 535                 540                 


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
545                 550                 555                 560 


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
                565                 570                 575     


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
            580                 585                 590         


Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser 
        595                 600                 605             


Asp Thr Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                645                 650                 655     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
            660                 665                 670         


Ser Asn Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        675                 680                 685             


Tyr Ile Gly Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp 
    690                 695                 700                 


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
705                 710                 715                 720 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                725                 730                 735     


Cys Ala Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu 
            740                 745                 750         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        755                 760             


<210>  146
<211>  763
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  146

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Leu Asp Ser Ser 
                85                  90                  95      


Val Asp Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        115                 120                 125             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    130                 135                 140                 


Ser Phe Ser Ser Asp Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Ile Gly Cys Ile Tyr Ala Gly Asp Val Asp Asp 
                165                 170                 175     


Thr Asp Tyr Ala Ser Trp Ala Arg Gly Arg Phe Thr Ile Ser Arg Asp 
            180                 185                 190         


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        195                 200                 205             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Asp Gly Phe Asp Ile Thr 
    210                 215                 220                 


Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            260                 265                 270         


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Thr Ile 
        275                 280                 285             


Asn Tyr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    290                 295                 300                 


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
305                 310                 315                 320 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                325                 330                 335     


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Tyr 
            340                 345                 350         


Ser Thr Ser Arg Ser Tyr Gly Phe Gly Gly Gly Thr Lys Leu Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    370                 375                 380                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
385                 390                 395                 400 


Gly Ile Asp Phe Ser Thr Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro 
                405                 410                 415     


Gly Lys Gly Leu Glu Trp Ile Ala Tyr Ile Tyr Pro Asp Tyr Gly Ile 
            420                 425                 430         


Thr Asp Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Ile Ser Leu Asp 
        435                 440                 445             


Asn Ala Gln Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    450                 455                 460                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Ser Tyr Tyr Ser Arg 
465                 470                 475                 480 


Gly Trp Gly Ala His Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val 
                485                 490                 495     


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
            500                 505                 510         


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
        515                 520                 525             


Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln 
    530                 535                 540                 


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
545                 550                 555                 560 


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
                565                 570                 575     


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
            580                 585                 590         


Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser 
        595                 600                 605             


Asp Thr Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                645                 650                 655     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser 
            660                 665                 670         


Ser Asn Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        675                 680                 685             


Tyr Ile Gly Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp 
    690                 695                 700                 


Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val 
705                 710                 715                 720 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe 
                725                 730                 735     


Cys Ala Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu 
            740                 745                 750         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        755                 760             


<210>  147
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  147

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Leu Asp Ser Ser 
                85                  90                  95      


Val Asp Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        115                 120                 125             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    130                 135                 140                 


Ser Phe Ser Ser Asp Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Ile Gly Cys Ile Tyr Ala Gly Asp Val Asp Asp 
                165                 170                 175     


Thr Asp Tyr Ala Ser Trp Ala Arg Gly Arg Phe Thr Ile Ser Arg Asp 
            180                 185                 190         


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        195                 200                 205             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Asp Gly Phe Asp Ile Thr 
    210                 215                 220                 


Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
            260                 265                 270         


Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Thr Ile Asn 
        275                 280                 285             


Tyr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
    290                 295                 300                 


Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
                325                 330                 335     


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Tyr Ser 
            340                 345                 350         


Thr Ser Arg Ser Tyr Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        355                 360                 365             


Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    370                 375                 380                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
385                 390                 395                 400 


Ile Asp Phe Ser Thr Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro Gly 
                405                 410                 415     


Lys Gly Leu Glu Trp Ile Ala Tyr Ile Tyr Pro Asp Tyr Gly Ile Thr 
            420                 425                 430         


Asp Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Ile Ser Leu Asp Asn 
        435                 440                 445             


Ala Gln Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    450                 455                 460                 


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Ser Tyr Tyr Ser Arg Gly 
465                 470                 475                 480 


Trp Gly Ala His Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met 
            500                 505                 510         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        515                 520                 525             


Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser 
    530                 535                 540                 


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp 
545                 550                 555                 560 


Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
                565                 570                 575     


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
            580                 585                 590         


Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr 
        595                 600                 605             


Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                645                 650                 655     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn 
            660                 665                 670         


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        675                 680                 685             


Gly Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys 
    690                 695                 700                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
705                 710                 715                 720 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                725                 730                 735     


Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly 
            740                 745                 750         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        755                 760     


<210>  148
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  148

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Leu Asp Ser Ser 
                85                  90                  95      


Val Asp Asp Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        115                 120                 125             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    130                 135                 140                 


Ser Phe Ser Ser Asp Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly 
145                 150                 155                 160 


Lys Gly Leu Glu Trp Ile Gly Cys Ile Tyr Ala Gly Asp Val Asp Asp 
                165                 170                 175     


Thr Asp Tyr Ala Ser Trp Ala Arg Gly Arg Phe Thr Ile Ser Arg Asp 
            180                 185                 190         


Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        195                 200                 205             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Asp Gly Phe Asp Ile Thr 
    210                 215                 220                 


Tyr Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
            260                 265                 270         


Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Thr Ile Asn 
        275                 280                 285             


Tyr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
    290                 295                 300                 


Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
305                 310                 315                 320 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
                325                 330                 335     


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Tyr Tyr Tyr Ser 
            340                 345                 350         


Thr Ser Arg Ser Tyr Gly Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        355                 360                 365             


Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    370                 375                 380                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
385                 390                 395                 400 


Ile Asp Phe Ser Thr Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro Gly 
                405                 410                 415     


Lys Gly Leu Glu Trp Ile Ala Tyr Ile Tyr Pro Asp Tyr Gly Ile Thr 
            420                 425                 430         


Asp Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Ile Ser Leu Asp Asn 
        435                 440                 445             


Ala Gln Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    450                 455                 460                 


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Ser Tyr Tyr Ser Arg Gly 
465                 470                 475                 480 


Trp Gly Ala His Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
                485                 490                 495     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Met 
            500                 505                 510         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        515                 520                 525             


Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr Ser Asn Asn Gln Leu Ser 
    530                 535                 540                 


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp 
545                 550                 555                 560 


Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
                565                 570                 575     


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
            580                 585                 590         


Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Ser Ser Ser Ser Asp Thr 
        595                 600                 605             


Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                645                 650                 655     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Asn 
            660                 665                 670         


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        675                 680                 685             


Gly Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys 
    690                 695                 700                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
705                 710                 715                 720 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                725                 730                 735     


Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala Phe Tyr Leu Trp Gly 
            740                 745                 750         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        755                 760     


<210>  149
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial antibody-related sequence

<400>  149

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Leu Asp Ser Ser 
                85                  90                  95      


Val Asp Asp Asn Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        115                 120                 125             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    130                 135                 140                 


Ser Leu Ser Ser Asn Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Glu Tyr Ile Gly Ile Ile Ser Val Gly Gly Phe Thr Tyr Tyr 
                165                 170                 175     


Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
            180                 185                 190         


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
        195                 200                 205             


Thr Tyr Phe Cys Ala Arg Asp Arg His Gly Gly Asp Ser Ser Gly Ala 
    210                 215                 220                 


Phe Tyr Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
            260                 265                 270         


Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Glu Ser Val Tyr 
        275                 280                 285             


Ser Asn Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
    290                 295                 300                 


Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser 
305                 310                 315                 320 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                325                 330                 335     


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe 
            340                 345                 350         


Ser Ser Ser Ser Asp Thr Ala Phe Gly Gly Gly Thr Lys Leu Thr Val 
        355                 360                 365             


Leu Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    370                 375                 380                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
385                 390                 395                 400 


Gly Ile Asp Phe Ser Thr Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro 
                405                 410                 415     


Gly Lys Gly Leu Glu Trp Ile Ala Tyr Ile Tyr Pro Asp Tyr Gly Ile 
            420                 425                 430         


Thr Asp Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Ile Ser Leu Asp 
        435                 440                 445             


Asn Ala Gln Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    450                 455                 460                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Ser Tyr Tyr Ser Arg 
465                 470                 475                 480 


Gly Trp Gly Ala His Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val 
                485                 490                 495     


Thr Val Ser Ser 
            500 


