                         SEQUENCE LISTING

<110>  ݿƼ޹˾
 
<120>  HER2˫Կ弰Ӧ

<130>  P20400304C

<150>  2019101090084
<151>  2019-02-03

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ɱWT

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  2
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  3
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ڶɱ飩WT

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  һɱ飩WT

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  5

Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp 
1               5                   10              


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  һHCDR2飩WT

<400>  6

Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  һHCDR2飩1

<400>  7

Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Leu Asn Arg Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  һHCDR2飩2

<400>  8

Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Leu Asn Val Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  һHCDR2飩3

<400>  9

Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Phe Asn Gln Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  һHCDR2飩4

<400>  10

Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Phe Asn His Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  һHCDR2飩5

<400>  11

Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Ile Asn Gln Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  һHCDR2飩6

<400>  12

Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Met Asn Gln Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  һHCDR2飩7

<400>  13

Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Thr Asn Gln Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  һHCDR3飩WT

<400>  14

Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr 
1               5                   10          


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  һHCDR3飩1

<400>  15

Ala Arg Asn Leu Gly Pro Trp Phe Tyr Phe Asp Tyr 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  һHCDR3飩2

<400>  16

Ala Arg Asn Leu Gly Pro Asn Phe Tyr Phe Asp Tyr 
1               5                   10          


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  һHCDR3飩3

<400>  17

Ala Arg Asn Leu Gly Pro Phe Phe Tyr Phe Asp Tyr 
1               5                   10          


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  һHCDR3飩4

<400>  18

Ala Arg Asn Leu Gly Pro Leu Phe Tyr Phe Asp Tyr 
1               5                   10          


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  һHCDR3飩5

<400>  19

Ala Arg Asn Leu Gly Pro Tyr Phe Tyr Phe Asp Tyr 
1               5                   10          


