                         序列表

<110>  长春金赛药业有限责任公司

<120>  人源化抗Aβ单克隆抗体及其应用

<130>  OP200051

<160>  51

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  5
<212>  PRT
<213>  重链的CDR区(CDR region of heavy chain)

<400>  1
Ser Tyr Ala Met Ser 
1               5   

<210>  2
<211>  16
<212>  PRT
<213>  重链的CDR区(CDR region of heavy chain)

<400>  2
Ser Ile Ser Thr Thr Ser Asn Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      

<210>  3
<211>  11
<212>  PRT
<213>  重链的CDR区(CDR region of heavy chain)

<400>  3
Gly Val Ile Thr Asn Gln Ala Trp Phe Ala Tyr 
1               5                   10      

<210>  4
<211>  11
<212>  PRT
<213>  轻链的CDR区(CDR region of the light chain)

<400>  4
Arg Ala Ser Gln Ser Ile Ser Asn Asn Leu His 
1               5                   10      

<210>  5
<211>  7
<212>  PRT
<213>  轻链的CDR区(CDR region of the light chain)

<400>  5
Tyr Ala Ser Gln Ser Ile Ser 
1               5           

<210>  6
<211>  9
<212>  PRT
<213>  轻链的CDR区(CDR region of the light chain)

<400>  6
Gln Gln Ser Asn Ser Trp Pro Leu Thr 
1               5                   

<210>  7
<211>  30
<212>  PRT
<213>  重链的FR区(FR region of heavy chain)

<400>  7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg 
            20                  25                  30  

<210>  8
<211>  14
<212>  PRT
<213>  重链的FR区(FR region of heavy chain)

<400>  8
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  

<210>  9
<211>  32
<212>  PRT
<213>  重链的FR区(FR region of heavy chain)

<400>  9
Arg Phe Thr Thr Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      
Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg 
            20                  25                  30          

<210>  10
<211>  11
<212>  PRT
<213>  重链的FR区(FR region of heavy chain)

<400>  10
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210>  11
<211>  23
<212>  PRT
<213>  轻链的FR区(FR region of light chain)

<400>  11
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys 
            20              

<210>  12
<211>  15
<212>  PRT
<213>  轻链的FR区(FR region of light chain)

<400>  12
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Lys 
1               5                   10                  15  

<210>  13
<211>  32
<212>  PRT
<213>  轻链的FR区(FR region of light chain)

<400>  13
Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Phe Cys 
            20                  25                  30          

<210>  14
<211>  10
<212>  PRT
<213>  轻链的FR区(FR region of light chain)

<400>  14
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  

<210>  15
<211>  119
<212>  PRT
<213>  066-4.26.14 H1

<400>  15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Ser Thr Thr Ser Asn Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      
Arg Gly Val Ile Thr Asn Gln Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210>  16
<211>  119
<212>  PRT
<213>  066-4.26.14 H2

<400>  16
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Ser Thr Thr Ser Asn Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr Leu 
65                  70                  75                  80  
Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      
Arg Gly Val Ile Thr Asn Gln Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                 

<210>  17
<211>  119
<212>  PRT
<213>  066-4.26.14 H3

<400>  17
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Arg Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Ser Thr Thr Ser Asn Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Val Thr Thr Ser Arg Asp Lys Ser Ile Ser Thr Ala Tyr Leu 
65                  70                  75                  80  
Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Gly 
                85                  90                  95      
Arg Gly Val Ile Thr Asn Gln Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210>  18
<211>  119
<212>  PRT
<213>  066-4.26.14 H4

<400>  18
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Ser Thr Thr Ser Asn Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr Leu 
65                  70                  75                  80  
Gln Met Ser Ser Leu Arg Asp Glu Asp Thr Ala Met Tyr Tyr Cys Gly 
                85                  90                  95      
Arg Gly Val Ile Thr Asn Gln Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         
Ile Leu Val Thr Val Ser Ser 
        115                 

<210>  19
<211>  119
<212>  PRT
<213>  066-4.26.14 H5

<400>  19
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Ser Thr Thr Ser Asn Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Thr Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      
Arg Gly Val Ile Thr Asn Gln Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210>  20
<211>  107
<212>  PRT
<213>  066-4.26.14 L1

<400>  20
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Gln Val Glu Ile Lys 
            100                 105         

<210>  21
<211>  107
<212>  PRT
<213>  066-4.26.14 L2

<400>  21
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  22
<211>  107
<212>  PRT
<213>  066-4.26.14 L3

<400>  22
Asp Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      
Glu Lys Val Thr Ile Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  
Glu Asp Ala Ala Ala Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      
Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  23
<211>  107
<212>  PRT
<213>  066-4.26.14 L4

<400>  23
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  24
<211>  107
<212>  PRT
<213>  066-4.26.14 L5

<400>  24
Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      
Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  
Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  25
<211>  357
<212>  DNA
<213>  066-4.26.14 H1

<400>  25
gaggtgcagc tggtggaatc aggaggagga ctggtgaagc caggcggatc tctgagactg        60
tcttgcgccg ccagcggctt taccttcaga tcttacgcca tgtcttgggt ccggcaggca       120
ccaggaaaag gactggagtg ggtggccagc atcagcacca ccagcaacac ctactacccc       180
gacagcgtga agggcagatt caccaccagc cgggacaacg ccaagaacag cctgtacctg       240
cagatgaaca gcctgagggc cgaggatacc gccgtgtact attgcggacg gggagtgatc       300
accaaccagg cttggttcgc ctattggggg cagggaacac tggtgaccgt gtctagc          357

<210>  26
<211>  357
<212>  DNA
<213>  066-4.26.14 H2

<400>  26
gaggtgcagc tggtggaatc aggaggagga ctggtgaagc caggcggatc tctgagactg        60
tcttgcgccg ccagcggctt taccttcaga agctacgcca tgtcttgggt ccggcagaca       120
ccagagaaga gactggagtg ggtggcctct atcagcacca ccagcaacac ctactacccc       180
gacagcgtga agggcagatt caccaccagc cgggacaacg ccaagaacag cgtgtacctg       240
cagatgagca gcctgagagc cgaggacaca gcagtgtact attgcggcag gggcgtgatc       300
accaaccagg cttggttcgc ctattggggg cagggaacaa ccgtgaccgt gtctagc          357

<210>  27
<211>  357
<212>  DNA
<213>  066-4.26.14 H3

<400>  27
gaagtgcagc tggtgcagag cggagcagaa gtgaagaagc ccggcgagtc cctgaagatc        60
tcttgcaagg gcagcggcta cagcttcagg agctacgcca tgtcttgggt ccggcagatg       120
ccaggaaaag gactggagtg ggtggcctct atcagcacca ccagcaacac ctactacccc       180
gacagcgtga agggcagagt gacaaccagc agggacaaga gcatcagcac cgcctacctg       240
cagtggtcta gcctgaaggc cagcgatacc gccatgtact attgcggccg gggagtgatc       300
accaaccagg cttggttcgc ctattggggg cagggaacac tggtgaccgt gtctagc          357

<210>  28
<211>  357
<212>  DNA
<213>  066-4.26.14 H4

<400>  28
gaggtgcagc tggtggaatc aggaggagga ctggtgcagc caggaggatc tctgagactg        60
tcttgcgccg ccagcggctt taccttcaga tcttacgcca tgtcttgggt ccggcaggca       120
ccaggaaaag gactggagtg ggtggccagc atcagcacca ccagcaacac ctactacccc       180
gacagcgtga agggcagatt caccaccagc cgggacaacg ccaagaacag cgtgtacctg       240
cagatgagca gcctgaggga cgaggatacc gccatgtact attgcggccg gggagtgatc       300
accaaccagg cttggttcgc ctattggggg cagggaatcc tggtgaccgt gtctagc          357

<210>  29
<211>  357
<212>  DNA
<213>  066-4.26.14 H5

<400>  29
gaggtgcagc tggtggaatc aggaggagga ctggtgcagc caggaggatc tctgagactg        60
tcttgcgtgg ccagcggctt caccttcaga tcttacgcca tgtcttgggt ccggcaggca       120
ccaggaaaag gactggagtg ggtggccagc atcagcacca ccagcaacac ctactacccc       180
gacagcgtga agggcagatt caccaccagc cgggacaaca gcaagaacac cgtgtacctg       240
cagatgagca gcctgagagc cgaggacaca gcagtgtact attgcggcag gggcgtgatc       300
accaaccagg cttggttcgc ctattggggg cagggaacac tggtgaccgt gtctagc          357

<210>  30
<211>  321
<212>  DNA
<213>  066-4.26.14 L1

<400>  30
gacatcgtgc tgacccagtc tccagccaca ctgagcgtgt ctccaggaga gagagtgacc        60
ctgtcttgca gagccagcca gagcatcagc aacaacctgc attggtacca gcagaagtcc       120
ggccaggctc ctaggctgct gatcaagtac gccagccaga gcattagcgg catcccttct       180
agattcagcg gcagcggaag cggcacagat ttcaccctga ccatcagcag cctgcagagc       240
gaggacttcg ccgtctactt ctgccagcag agcaactctt ggcccctgac ctttggcgga       300
ggcacccagg tggagatcaa g                                                 321

<210>  31
<211>  321
<212>  DNA
<213>  066-4.26.14 L2

<400>  31
gacatcgtgc tgacccagtc tccagccaca ctgagcgtgt ctccaggaga gagagccaca        60
ctgtcttgca gagccagcca gagcatcagc aacaacctgc attggtacca gcagaagcca       120
ggccaggctc ctaggctgct gatcaagtac gcctctcagt ctatcagcgg catcccagct       180
agattcagcg gcagcggaag cggcacagac ttcaccctga ccatcagcag cctgcagagc       240
gaggacttcg ccgtctactt ctgccagcag agcaactctt ggcccctgac ctttggcgga       300
ggcaccaagg tggagatcaa g                                                 321

<210>  32
<211>  321
<212>  DNA
<213>  066-4.26.14 L3

<400>  32
gacatcgtgc tgacccagag cccagacttc cagtcagtga cccccaagga gaaggtcacc        60
atcagctgca gagccagcca gagcatcagc aacaacctgc attggtacca gcagaagccc       120
gaccagagcc ccaagctgct gatcaagtac gccagccagt ctatcagcgg catcccttct       180
agattcagcg gcagcggaag cggcacagat ttcaccctga ccatcaacag cctggaggcc       240
gaagacgcag ccgcctactt ttgccagcag agcaactctt ggcccctgac ctttggccct       300
ggcaccaagg tggagatcaa g                                                 321

<210>  33
<211>  321
<212>  DNA
<213>  066-4.26.14 L4

<400>  33
gagatcgtgc tgacccagtc tccaggcaca ctgtctctga gcccaggaga gagagccaca        60
ctgtcttgca gagccagcca gagcatcagc aacaacctgc attggtacca gcagaagcca       120
ggccaggctc ctaggctgct gatcaagtac gccagccaga gcattagcgg catcccagat       180
agattcagcg gcagcggaag cggcacagat ttcaccctga ccatcagcag actggagccc       240
gaggacttcg ccgtgtacta ttgccagcag agcaactctt ggcccctgac ctttggcgga       300
ggcaccaagg tggagatcaa g                                                 321

<210>  34
<211>  321
<212>  DNA
<213>  066-4.26.14 L5

<400>  34
gagatcgtgc tgacccagag cccagacttc cagtcagtga cccccaagga gaaggtcacc        60
atcacttgca gggccagcca gagcatcagc aacaacctgc attggtacca gcagaagccc       120
gaccagagcc ccaagctgct gatcaagtac gccagccagt ctatcagcgg agtgccttct       180
agattcagcg gcagcggaag cggcacagat ttcaccctga ccatcaacag cctggaggca       240
gaggacgcag ccacctacta ttgccagcag agcaactctt ggcccctgac cttcggacag       300
ggcaccaagg tggagatcaa g                                                 321

<210>  35
<211>  42
<212>  PRT
<213>  Aβ1-42

<400>  35
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      
Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          
Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          

<210>  36
<211>  16
<212>  PRT
<213>  Aβ1-16

<400>  36
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      

<210>  37
<211>  17
<212>  PRT
<213>  Aβ14-29

<400>  37
His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly 
1               5                   10                  15      
Ala 
    

<210>  38
<211>  112
<212>  PRT
<213>  066-P01阳性抗体重链可变区(heavy chain variable region of 066-P01 positive antibody )

<400>  38
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              
Ala Gln Ile Asn Ser Val Gly Asn Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         

<210>  39
<211>  112
<212>  PRT
<213>  066-P01阳性抗体轻链可变区(light chain variable region of 066-P01 positive antibody )

<400>  39
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ile Tyr Ser 
            20                  25                  30          
Asp Gly Asn Ala Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  40
<211>  124
<212>  PRT
<213>  066-P02阳性抗体重链可变区(heavy chain variable region of 066-P02 positive antibody )

<400>  40
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Trp Phe Asp Gly Thr Lys Lys Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Gly Ile Gly Ala Arg Arg Gly Pro Tyr Tyr Met Asp 
            100                 105                 110         
Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 

<210>  41
<211>  107
<212>  PRT
<213>  066-P02阳性抗体轻链可变区(light chain variable region of 066-P02 positive antibody )

<400>  41
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  42
<211>  21
<212>  DNA
<213>  mIgGR

<400>  42
ctcagggaar tarccyttga c                                                  21

<210>  43
<211>  21
<212>  DNA
<213>  mIgKR

<400>  43
tcactgccat caatcttcca c                                                  21

<210>  44
<211>  18
<212>  DNA
<213>  M13F

<400>  44
tgtaaaacga cggccagt                                                      18

<210>  45
<211>  18
<212>  DNA
<213>  M13R

<400>  45
caggaaacag ctatgacc                                                      18

<210>  46
<211>  357
<212>  DNA
<213>  066-4.26.14 抗体的重链可变区(Heavy chain variable region of  066-4.26.14 antibody)

<400>  46
gaagtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc        60
tcctgtgcag cctctggatt cactttcaga agttatgcca tgtcttgggt tcgccagact       120
ccagagaaga ggctggagtg ggtcgcatcc attagtacta ctagtaacac ctactatcca       180
gacagtgtga agggccgatt caccacctcc agagataacg ccaggaacat cgtgtacctg       240
caaatgagca gtctgaggtc tgacgacacg gccatgtatt actgtggaag aggcgtgatt       300
acgaaccagg cctggtttgc ttactggggc caagggactc tggtcactgt ctctgca          357

<210>  47
<211>  321
<212>  DNA
<213>  066-4.26.14 抗体的轻链可变区(Light chain variable region of  066-4.26.14 antibody)

<400>  47
gatattgtgc taactcagtc tccagccacc ctgtctgtga ctccaggaga tagcgtcagt        60
ctttcctgca gggccagcca aagtattagc aacaacctac actggtatca gcaaaaatca       120
catgagtctc caaggcttct catcaagtat gcttcccagt ccatctctgg gatcccctcc       180
aggttcagtg gcagtggatc agggacagat ttcactctca gtgtcaacaa tgtggggact       240
gaagattttg gaatgtattt ctgtcaacag agtaacagct ggccgctcac gttcggtgct       300
gggaccaagc tggagctgaa a                                                 321

<210>  48
<211>  119
<212>  PRT
<213>  066-4.26.14 抗体的重链可变区(Heavy chain variable region of  066-4.26.14 antibody)

<400>  48
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Ser Thr Thr Ser Asn Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Arg Asn Ile Val Tyr Leu 
65                  70                  75                  80  
Gln Met Ser Ser Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys Gly 
                85                  90                  95      
Arg Gly Val Ile Thr Asn Gln Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala 
        115                 

<210>  49
<211>  107
<212>  PRT
<213>  066-4.26.14 抗体的轻链可变区(Light chain variable region of  066-4.26.14 antibody)

<400>  49
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Val Asn Asn Val Gly Thr 
65                  70                  75                  80  
Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210>  50
<211>  448
<212>  PRT
<213>  066-4.26.14鼠人嵌合抗体重链( heavy chain of 066-4.26.14 murine chimeric antibody)

<400>  50
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              
Ala Ser Ile Ser Thr Thr Ser Asn Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Arg Asn Ile Val Tyr Leu 
65                  70                  75                  80  
Gln Met Ser Ser Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys Gly 
                85                  90                  95      
Arg Gly Val Ile Thr Asn Gln Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             

<210>  51
<211>  214
<212>  PRT
<213>  066-4.26.14鼠人嵌合抗体轻链( light chain of 066-4.26.14 murine chimeric antibody)

<400>  51
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Val Asn Asn Val Gly Thr 
65                  70                  75                  80  
Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

