                         序列表

<110>  长春金赛药业有限责任公司

<120>  人源化抗Aβ单克隆抗体及其应用

<130>  OP200052
<160>  51

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  5
<212>  PRT
<213>  重链的CDR区(CDR region of heavy chain)

<400>  1
Asn Tyr Asn Ile His 
1               5   

<210>  2
<211>  17
<212>  PRT
<213>  重链的CDR区(CDR region of heavy chain)

<400>  2
Ala Ile Tyr Pro Gly Asn Gly Asp Thr Thr Tyr Asn Gln Lys Val Lys 
1               5                   10                  15      
Gly 
    

<210>  3
<211>  8
<212>  PRT
<213>  重链的CDR区(CDR region of heavy chain)

<400>  3
Gly Asp Trp Asp Trp Phe Ala Tyr 
1               5               

<210>  4
<211>  16
<212>  PRT
<213>  轻链的CDR区(CDR region of the light chain)

<400>  4
Ser Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      

<210>  5
<211>  7
<212>  PRT
<213>  轻链的CDR区(CDR region of the light chain)

<400>  5
Arg Met Ser Asn Leu Ala Ser 
1               5           

<210>  6
<211>  9
<212>  PRT
<213>  轻链的CDR区(CDR region of the light chain)

<400>  6
Ala Gln Met Leu Glu Arg Pro Leu Thr 
1               5                   

<210>  7
<211>  30
<212>  PRT
<213>  重链的FR区(FR region of heavy chain)

<400>  7
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  

<210>  8
<211>  14
<212>  PRT
<213>  重链的FR区(FR region of heavy chain)

<400>  8
Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile Gly 
1               5                   10                  

<210>  9
<211>  32
<212>  PRT
<213>  重链的FR区(FR region of heavy chain)

<400>  9
Lys Ala Thr Leu Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      
Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          

<210>  10
<211>  11
<212>  PRT
<213>  重链的FR区(FR region of heavy chain)

<400>  10
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210>  11
<211>  23
<212>  PRT
<213>  轻链的FR区(FR region of light chain)

<400>  11
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys 
            20              

<210>  12
<211>  15
<212>  PRT
<213>  轻链的FR区(FR region of light chain)

<400>  12
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  

<210>  13
<211>  32
<212>  PRT
<213>  轻链的FR区(FR region of light chain)

<400>  13
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          

<210>  14
<211>  10
<212>  PRT
<213>  轻链的FR区(FR region of light chain)

<400>  14
Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
1               5                   10  

<210>  15
<211>  117
<212>  PRT
<213>  066-5.4.1 H1

<400>  15
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Thr Tyr Asn Gln Lys Val 
    50                  55                  60                  
Lys Gly Lys Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Asp Trp Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  16
<211>  117
<212>  PRT
<213>  066-5.4.1 H2

<400>  16
Gln Met Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Asn Ile His Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Thr Tyr Asn Gln Lys Val 
    50                  55                  60                  
Lys Gly Lys Val Thr Leu Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Asp Trp Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  17
<211>  117
<212>  PRT
<213>  066-5.4.1 H3

<400>  17
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Asn Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Thr Tyr Asn Gln Lys Val 
    50                  55                  60                  
Lys Gly Lys Val Thr Leu Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Asp Trp Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  18
<211>  117
<212>  PRT
<213>  066-5.4.1 H4

<400>  18
Gln Val Gln Leu Gln Gln Pro Gly Ala Asp Leu Val Met Pro Gly Ala 
1               5                   10                  15      
Pro Val Lys Leu Ser Cys Leu Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Asn Ile His Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Thr Tyr Asn Gln Lys Val 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Asp Trp Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ala 
        115         

<210>  19
<211>  117
<212>  PRT
<213>  066-5.4.1 H5

<400>  19
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Thr Tyr Asn Gln Lys Val 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Asp Trp Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210>  20
<211>  112
<212>  PRT
<213>  066-5.4.1 L1

<400>  20
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Ser Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Met 
                85                  90                  95      
Leu Glu Arg Pro Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         

<210>  21
<211>  112
<212>  PRT
<213>  066-5.4.1 L2

<400>  21
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Ser Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Arg Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Val Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Phe Tyr Tyr Cys Ala Gln Met 
                85                  90                  95      
Leu Glu Arg Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Leu Lys 
            100                 105                 110         

<210>  22
<211>  112
<212>  PRT
<213>  066-5.4.1 L3

<400>  22
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Ser Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Met 
                85                  90                  95      
Leu Glu Arg Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         

<210>  23
<211>  112
<212>  PRT
<213>  066-5.4.1 L4

<400>  23
Asp Ile Val Met Thr Gln Ser Pro Pro Ser Leu Ala Val Thr Pro Gly 
1               5                   10                  15      
Glu Pro Ala Ser Ile Ser Cys Ser Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ala 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Met 
                85                  90                  95      
Leu Glu Arg Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  24
<211>  112
<212>  PRT
<213>  066-5.4.1 L5

<400>  24
Asp Ile Val Met Thr Gln Ser Pro Leu Phe Leu Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Ala Ala Ser Leu Ser Cys Ser Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Thr 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ser Asp Asp Val Gly Thr Tyr Tyr Cys Ala Gln Met 
                85                  90                  95      
Leu Glu Arg Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  25
<211>  351
<212>  DNA
<213>  066-5.4.1 H1

<400>  25
caggtgcagc tggtgcagtc aggagcagaa gtgaagaagc ccggagccag cgtgaaagtg        60
tcttgcaagg ccagcggcta caccttcacc aactacaaca tccattgggt ccggcaggct       120
ccaggacagg gactggagtg gatgggagca atctacccag gcaacggcga caccacctac       180
aaccagaagg tcaagggcaa ggtcaccctg accagagaca ccagcaccag caccgtgtac       240
atggagctga gcagcctgag gagcgaggat acagccgtgt actattgcgc caggggcgat       300
tgggattggt tcgcctattg ggggcaggga acactggtga cagtgtccag c                351

<210>  26
<211>  351
<212>  DNA
<213>  066-5.4.1 H2

<400>  26
cagatgcagc tggtgcagag cggaccagaa gtgaagaagc ccggaaccag cgtgaaggtg        60
tcttgcaagg ccagcggcta caccttcacc aactacaaca tccattgggt ccggcaggcc       120
agaggacaga gactggagtg gatcggagcc atctacccag gcaacggcga caccacctac       180
aaccagaagg tcaagggcaa ggtcaccctg accagagaca tgagcaccag caccgcctac       240
atggagctgt ctagcctgag gagcgaggac acagccgtgt actattgcgc caggggcgat       300
tgggattggt tcgcctattg ggggcaggga acactggtga cagtgtccag c                351

<210>  27
<211>  351
<212>  DNA
<213>  066-5.4.1 H3

<400>  27
gaagtgcagc tggtgcagag cggagcagaa gtgaagaagc ccggcgagtc cctgaagatc        60
tcttgcaagg gcagcggcta caccttcacc aactacaaca tccattgggt ccggcagatg       120
ccaggcaaag gactggagtg gatgggagca atctacccag gcaacggcga caccacctac       180
aaccagaagg tcaagggcaa ggtcaccctg agcgccgata agagcatcag caccgcctac       240
ctgcagtggt ctagcctgaa ggccagcgat accgccatgt actattgcgc caggggcgat       300
tgggattggt tcgcctattg ggggcaggga acactggtga cagtgtccag c                351

<210>  28
<211>  351
<212>  DNA
<213>  066-5.4.1 H4

<400>  28
caggtgcagc tgcagcagcc aggagccgac ctggtcatgc caggagcccc cgtgaagctg        60
tcctgcctgg cctctggcta caccttcaca aactataata tccactgggt gaagcagagg       120
ccaggaagag gactggagtg gatcggagcc atctaccccg gcaacggcga caccacatat       180
aatcagaagg tgaagggcaa ggccaccctg acagccgata agagctcctc taccgcctac       240
atccagctga gctccctgac atctgaggat agcgccgtgt actattgtgc ccggggcgac       300
tgggattggt ttgcctattg gggccagggc accctggtga cagtgtccgc c                351

<210>  29
<211>  351
<212>  DNA
<213>  066-5.4.1 H5

<400>  29
caggtgcagc tggtgcagag cggagccgag gtgaagaagc caggggccag cgtgaaggtg        60
tcctgcaagg cctctggcta caccttcaca aactataata tccactgggt gcggcaggcc       120
cccggacaga gactggagtg gatcggagcc atctaccctg gcaacggcga caccacatat       180
aatcagaagg tgaagggcaa ggccaccctg acagccgata agtccgcctc taccgcctac       240
atggagctga gctccctgag gtccgaggac acagccgtgt actattgtgc ccggggcgac       300
tgggattggt ttgcctattg gggccagggc accctggtga cagtgtctag c                351

<210>  30
<211>  336
<212>  DNA
<213>  066-5.4.1 L1

<400>  30
gacatcgtga tgacccagtc tcccctgagc ctgcctgtga cactgggaca gccagccagc        60
atctcctgca gctcctctaa gtccctgctg cactctaacg gcatcaccta cctgtattgg       120
taccagcaga ggccaggaca gtctccaagg ctgctgatct atagaatgag caatctggcc       180
tccggagtgc ctgaccggtt ctctggcagc ggctccggaa ccgacttcac cctgaagatc       240
tccagggtgg aggccgagga tgtgggcgtg tactattgtg cccagatgct ggagaggcca       300
ctgaccttcg gccagggaac aaggctggag atcaag                                 336

<210>  31
<211>  336
<212>  DNA
<213>  066-5.4.1 L2

<400>  31
gacatcgtga tgacccagac accactgagc ctgtccgtga ccccaggaca gcctgcctct        60
atcagctgca gctcctctaa gagcctgctg cactccaacg gcatcacata cctgtattgg       120
tacaggcaga agccaggaca gtccccacag ctgctgatct ataggatgtc taatctggcc       180
agcggagtgc ctgaccgctt cgtgggctcc ggctctggaa ccgacttcac cctgcggatc       240
tctagagtgg aggccgagga cgtgggcttc tactattgtg cccagatgct ggagaggcca       300
ctgacctttg gcggcggcac aaaggtggat ctgaag                                 336

<210>  32
<211>  336
<212>  DNA
<213>  066-5.4.1 L3

<400>  32
gacatcgtga tgacccagac acctctgtct ctgccagtga cccctggaga gccagccagc        60
atctcctgca gctcctctaa gtctctgctg cacagcaacg gcatcacata cctgtattgg       120
tacctgcaga agcccggcca gagccctagg ctgctgatct atcgcatgtc caatctggcc       180
tctggagtgc cagaccggtt ctctggcagc ggctccggaa ccgacttcac cctgcggatc       240
tccagagtgg aggccgagga cgtgggcgtg tactattgtg cccagatgct ggagaggccc       300
ctgaccttcg gccagggaac aaaggtggat atcaag                                 336

<210>  33
<211>  336
<212>  DNA
<213>  066-5.4.1 L4

<400>  33
gacatcgtga tgacccagtc tccacctagc ctggccgtga caccaggaga gccagccagc        60
atctcctgca gctcctctaa gtccctgctg cactctaacg gcatcaccta cctgtattgg       120
tacctgcaga agcctggcca ggccccacag ctgctgatct atcggatgag caatctggcc       180
tccggcgtgc ccgacagatt ctctggcagc ggctccggaa ccgacttcac cctgaagatc       240
tctagggtgg aggccgagga tgtgggcgtg tactattgtg cccagatgct ggagcggcct       300
ctgaccttcg gccagggaac aaagctggag atcaag                                 336

<210>  34
<211>  336
<212>  DNA
<213>  066-5.4.1 L5

<400>  34
gacatcgtga tgacccagtc tcccctgttc ctgccagtga cacctggaga ggcagccagc        60
ctgtcctgca gctcctctaa gtctctgctg cacagcaacg gcatcaccta cctgtattgg       120
tacctgcaga ggccaggaca gacaccaagg ctgctgatct atagaatgtc caatctggcc       180
tctggcgtgc ctgacaggtt ctctggcagc ggctccggaa ccgacttcac cctgaagatc       240
agccgcgtgg agtccgacga tgtgggcacc tactattgtg cccagatgct ggagaggcca       300
ctgacctttg gccagggcac aaaggtggag atcaag                                 336

<210>  35
<211>  42
<212>  PRT
<213>  Aβ1-42

<400>  35
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      
Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          
Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          

<210>  36
<211>  16
<212>  PRT
<213>  Aβ1-16

<400>  36
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      

<210>  37
<211>  17
<212>  PRT
<213>  Aβ14-29

<400>  37
His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly 
1               5                   10                  15      
Ala 
    

<210>  38
<211>  112
<212>  PRT
<213>  066-P01阳性抗体重链可变区(heavy chain variable region of 066-P01 positive antibody )

<400>  38
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              
Ala Gln Ile Asn Ser Val Gly Asn Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         

<210>  39
<211>  112
<212>  PRT
<213>  066-P01阳性抗体轻链可变区(light chain variable region of 066-P01 positive antibody )

<400>  39
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ile Tyr Ser 
            20                  25                  30          
Asp Gly Asn Ala Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  40
<211>  124
<212>  PRT
<213>  066-P02阳性抗体重链可变区(heavy chain variable region of 066-P02 positive antibody )

<400>  40
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Trp Phe Asp Gly Thr Lys Lys Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Gly Ile Gly Ala Arg Arg Gly Pro Tyr Tyr Met Asp 
            100                 105                 110         
Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 

<210>  41
<211>  107
<212>  PRT
<213>  066-P02阳性抗体轻链可变区(light chain variable region of 066-P02 positive antibody )

<400>  41
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  42
<211>  21
<212>  DNA
<213>  mIgGR

<400>  42
ctcagggaar tarccyttga c                                                  21

<210>  43
<211>  21
<212>  DNA
<213>  mIgKR

<400>  43
tcactgccat caatcttcca c                                                  21

<210>  44
<211>  18
<212>  DNA
<213>  M13F

<400>  44
tgtaaaacga cggccagt                                                      18

<210>  45
<211>  18
<212>  DNA
<213>  M13R

<400>  45
caggaaacag ctatgacc                                                      18

<210>  46
<211>  351
<212>  DNA
<213>  066-5.4.1 抗体的重链可变区(Heavy chain variable region of  066-5.4.1 antibody)

<400>  46
caggtgcaac tacagcagcc tggggctgcg ctggtgaagc ctggggcctc agtgcagatg        60
tcctgcaagg cttctggcta cacatttacc aattacaata tacactgggt aaagcagaca       120
cctggacagg gcctggaatg gattggagct atctatccag gaaatggtga tactacctac       180
aatcagaagg tcaaaggcaa ggccacattg actgcagaca aatcctccag cacagcctac       240
ttgcagctca gcagcctgac atctgaggac tctgcggtct actactgtgc aagaggggac       300
tgggactggt ttgcttactg gggccaaggg actctggtca ctgtctctgc a                351

<210>  47
<211>  336
<212>  DNA
<213>  066-5.4.1 抗体的轻链可变区(Light chain variable region of  066-5.4.1 antibody)

<400>  47
gatattgtga tgacgcaggc tgtattctcc aatccagtca ctcttggaac atcagcttcc        60
atctcttgca gttctagtaa gagtctccta catagtaatg gcatcactta tttgtattgg       120
tatctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc       180
tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgatttcac actgagaatc       240
agcagagtgg aggctgagga tgtgggtgtt tattactgtg ctcaaatgct agaacgcccg       300
ctcacgttcg gtgctgggac caagctggag ctgaaa                                 336

<210>  48
<211>  117
<212>  PRT
<213>  066-5.4.1 抗体的重链可变区(Heavy chain variable region of  066-5.4.1 antibody)

<400>  48
Gln Val Gln Leu Gln Gln Pro Gly Ala Ala Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Gln Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Asn Ile His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Thr Tyr Asn Gln Lys Val 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Asp Trp Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ala 
        115         

<210>  49
<211>  112
<212>  PRT
<213>  066-5.4.1 抗体的轻链可变区(Light chain variable region of  066-5.4.1 antibody)

<400>  49
Asp Ile Val Met Thr Gln Ala Val Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      
Thr Ser Ala Ser Ile Ser Cys Ser Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Met 
                85                  90                  95      
Leu Glu Arg Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         

<210>  50
<211>  446
<212>  PRT
<213>  066-5.4.1 鼠人嵌合抗体重链( heavy chain of 066-5.4.1 murine chimeric antibody)

<400>  50
Gln Val Gln Leu Gln Gln Pro Gly Ala Ala Leu Val Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Gln Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Asn Ile His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Thr Tyr Asn Gln Lys Val 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Asp Trp Asp Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     

<210>  51
<211>  219
<212>  PRT
<213>  066-5.4.1 鼠人嵌合抗体轻链( light chain of 066-5.4.1 murine chimeric antibody)

<400>  51
Asp Ile Val Met Thr Gln Ala Val Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      
Thr Ser Ala Ser Ile Ser Cys Ser Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Met 
                85                  90                  95      
Leu Glu Arg Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 

