                         序列表

<110>  长春金赛药业有限责任公司

<120>  人源化抗Aβ单克隆抗体及其应用

<130>  OP200053

<160>  51

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  5
<212>  PRT
<213>  重链的CDR区(CDR region of heavy chain)

<400>  1
Ser Tyr Gly Met His 
1               5   

<210>  2
<211>  17
<212>  PRT
<213>  重链的CDR区(CDR region of heavy chain)

<400>  2
Met Ile Trp Tyr Asp Gly Thr Lys Lys Tyr Tyr Ser Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  3
<211>  15
<212>  PRT
<213>  重链的CDR区(CDR region of heavy chain)

<400>  3
Asp Arg Gly Ile Gly Thr Arg His Gly Pro Tyr Phe Met Asp Val 
1               5                   10                  15  

<210>  4
<211>  10
<212>  PRT
<213>  轻链的CDR区(CDR region of the light chain)

<400>  4
His Ala Arg His Asn Val Arg Ser Tyr Leu 
1               5                   10  

<210>  5
<211>  7
<212>  PRT
<213>  轻链的CDR区(CDR region of the light chain)

<400>  5
Ala Ala Ser Ser Gln Gln Arg 
1               5           

<210>  6
<211>  9
<212>  PRT
<213>  轻链的CDR区(CDR region of the light chain)

<400>  6
Leu Gln Ser Phe Gly Thr Pro Leu Thr 
1               5                   

<210>  7
<211>  30
<212>  PRT
<213>  重链的FR区(FR region of heavy chain)

<400>  7
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Phe Ala Phe Arg 
            20                  25                  30  

<210>  8
<211>  14
<212>  PRT
<213>  重链的FR区(FR region of heavy chain)

<400>  8
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  

<210>  9
<211>  32
<212>  PRT
<213>  重链的FR区(FR region of heavy chain)

<400>  9
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          

<210>  10
<211>  11
<212>  PRT
<213>  重链的FR区(FR region of heavy chain)

<400>  10
Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      

<210>  11
<211>  23
<212>  PRT
<213>  轻链的FR区(FR region of light chain)

<400>  11
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys 
            20              

<210>  12
<211>  15
<212>  PRT
<213>  轻链的FR区(FR region of light chain)

<400>  12
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210>  13
<211>  32
<212>  PRT
<213>  轻链的FR区(FR region of light chain)

<400>  13
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          

<210>  14
<211>  10
<212>  PRT
<213>  轻链的FR区(FR region of light chain)

<400>  14
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  

<210>  15
<211>  124
<212>  PRT
<213>  066-7.17.2 H1

<400>  15
Gln Val Gln Leu Val Asp Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Phe Ala Phe Arg Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Met Ile Trp Tyr Asp Gly Thr Lys Lys Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Gly Ile Gly Thr Arg His Gly Pro Tyr Phe Met Asp 
            100                 105                 110         
Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 

<210>  16
<211>  124
<212>  PRT
<213>  066-7.17.2 H2

<400>  16
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Phe Ala Phe Arg Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Met Ile Trp Tyr Asp Gly Thr Lys Lys Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Arg Gly Ile Gly Thr Arg His Gly Pro Tyr Phe Met Asp 
            100                 105                 110         
Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 

<210>  17
<211>  124
<212>  PRT
<213>  066-7.17.2 H3

<400>  17
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Phe Ala Phe Arg Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Met Ile Trp Tyr Asp Gly Thr Lys Lys Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Gly Ile Gly Thr Arg His Gly Pro Tyr Phe Met Asp 
            100                 105                 110         
Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 

<210>  18
<211>  124
<212>  PRT
<213>  066-7.17.2 H4

<400>  18
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Phe Ala Phe Arg Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Met Ile Trp Tyr Asp Gly Thr Lys Lys Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Arg Gly Ile Gly Thr Arg His Gly Pro Tyr Phe Met Asp 
            100                 105                 110         
Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 

<210>  19
<211>  124
<212>  PRT
<213>  066-7.17.2 H5

<400>  19
Glu Val Gln Leu Val Glu Ser Gly Gly Val Val Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Phe Ala Phe Arg Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Met Ile Trp Tyr Asp Gly Thr Lys Lys Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Thr Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Arg Gly Ile Gly Thr Arg His Gly Pro Tyr Phe Met Asp 
            100                 105                 110         
Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 

<210>  20
<211>  107
<212>  PRT
<213>  066-7.17.2 L1

<400>  20
Asn Ile Gln Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys His Ala Arg His Asn Val Arg Ser Tyr 
            20                  25                  30          
Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys His Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Gln Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Phe Gly Thr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  21
<211>  107
<212>  PRT
<213>  066-7.17.2 L2

<400>  21
Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys His Ala Arg His Asn Val Arg Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Gln Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Phe Gly Thr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  22
<211>  107
<212>  PRT
<213>  066-7.17.2 L3

<400>  22
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys His Ala Arg His Asn Val Arg Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Gln Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Phe Gly Thr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  23
<211>  107
<212>  PRT
<213>  066-7.17.2 L4

<400>  23
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys His Ala Arg His Asn Val Arg Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Arg Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Gln Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Gly Leu Gln Ser Phe Gly Thr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  24
<211>  107
<212>  PRT
<213>  066-7.17.2 L5

<400>  24
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys His Ala Arg His Asn Val Arg Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Gln Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ser Phe Gly Thr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  25
<211>  372
<212>  DNA
<213>  066-7.17.2 H1

<400>  25
caggtgcagc tggtggacag cggcggcggc gtggtgcagc ccggccgcag cctgcgcctg        60
agctgcgccg ccagcgactt cgccttccgc agctacggca tgcactgggt gcgccaggcc       120
cccggcaagg gcctggagtg ggtggccatg atctggtacg acggcaccaa gaagtactac       180
agcgacagcg tgaagggccg cttcaccatc agccgcgaca acagcaagaa caccctgtac       240
ctgcagatga acaccctgcg cgccgaggac accgccgtgt actactgcgc ccgcgaccgc       300
ggcatcggca cccgccacgg cccctacttc atggacgtgt ggggcaaggg caccaccgtg       360
accgtgagca gc                                                           372

<210>  26
<211>  372
<212>  DNA
<213>  066-7.17.2 H2

<400>  26
caggtgcagc tggtggagag cggcggcggc gtggtgcagc ccggcggcag cctgcgcctg        60
agctgcgccg ccagcgactt cgccttccgc agctacggca tgcactgggt gcgccaggcc       120
cccggcaagg gcctggagtg ggtggccatg atctggtacg acggcaccaa gaagtactac       180
agcgacagcg tgaagggccg cttcaccatc agccgcgaca acagcaagaa caccctgtac       240
ctgcagatga acaccctgcg cgccgaggac accgccgtgt actactgcgc caaggaccgc       300
ggcatcggca cccgccacgg cccctacttc atggacgtgt ggggcaaggg caccaccgtg       360
accgtgagca gc                                                           372

<210>  27
<211>  372
<212>  DNA
<213>  066-7.17.2 H3

<400>  27
caggtgcagc tggtggagag cggcggcggc gtggtgcagc ccggccgcag cctgcgcctg        60
agctgcgccg ccagcgactt cgccttccgc agctacggca tgcactgggt gcgccaggcc       120
cccggcaagg gcctggagtg ggtggccatg atctggtacg acggcaccaa gaagtactac       180
agcgacagcg tgaagggccg cttcaccatc agccgcgaca acagcaagaa caccctgtac       240
ctgcagatga acaccctgcg cgccgaggac accgccgtgt actactgcgc ccgcgaccgc       300
ggcatcggca cccgccacgg cccctacttc atggacgtgt ggggcaaggg caccaccgtg       360
accgtgagca gc                                                           372

<210>  28
<211>  372
<212>  DNA
<213>  066-7.17.2 H4

<400>  28
gaggtgcagc tgctggagag cggcggcggc ctggtgcagc ccggcggcag cctgcgcctg        60
agctgcgccg ccagcgactt cgccttccgc agctacggca tgcactgggt gcgccaggcc       120
cccggcaagg gcctggagtg ggtgagcatg atctggtacg acggcaccaa gaagtactac       180
agcgacagcg tgaagggccg cttcaccatc agccgcgaca acagcaagaa caccctgtac       240
ctgcagatga acaccctgcg cgccgaggac accgccgtgt actactgcgc caaggaccgc       300
ggcatcggca cccgccacgg cccctacttc atggacgtgt ggggcaaggg caccaccgtg       360
accgtgagca gc                                                           372

<210>  29
<211>  372
<212>  DNA
<213>  066-7.17.2 H5

<400>  29
gaggtgcagc tggtggagag cggcggcgtg gtggtgcagc ccggcggcag cctgcgcctg        60
agctgcgccg ccagcgactt cgccttccgc agctacggca tgcactgggt gcgccaggcc       120
cccggcaagg gcctggagtg ggtgagcatg atctggtacg acggcaccaa gaagtactac       180
agcgacagcg tgaagggccg cttcaccatc agccgcgaca acagcaagaa cagcctgtac       240
ctgcagatga acaccctgcg caccgaggac accgccctgt actactgcgc caaggaccgc       300
ggcatcggca cccgccacgg cccctacttc atggacgtgt ggggcaaggg caccaccgtg       360
accgtgagca gc                                                           372

<210>  30
<211>  321
<212>  DNA
<213>  066-7.17.2 L1

<400>  30
aacatccaga tgacccagag ccccagcgcc atgagcgcca gcgtgggcga ccgcgtgacc        60
atcacctgcc acgcccgcca caacgtgcgc agctacctga actggttcca gcagaagccc       120
ggcaaggtgc ccaagcacct gatctacgcc gccagcagcc agcagcgcgg cgtgcccagc       180
cgcttcagcg gcagcggcag cggcaccgag ttcaccctga ccatcagcag cctgcagccc       240
gaggacttcg ccacctacta ctgcctgcag agcttcggca cccccctgac cttcggcggc       300
ggcaccaagg tggagatcaa g                                                 321

<210>  31
<211>  321
<212>  DNA
<213>  066-7.17.2 L2

<400>  31
gacatccaga tgacccagag ccccagcttc ctgagcgcca gcgtgggcga ccgcgtgacc        60
atcacctgcc acgcccgcca caacgtgcgc agctacctga actggtacca gcagaagccc       120
ggcaaggccc ccaagctgct gatctacgcc gccagcagcc agcagcgcgg cgtgcccagc       180
cgcttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc       240
gaggacttcg ccacctacta ctgcctgcag agcttcggca cccccctgac cttcggcggc       300
ggcaccaagg tggagatcaa g                                                 321

<210>  32
<211>  321
<212>  DNA
<213>  066-7.17.2 L3

<400>  32
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgcgtgacc        60
atcacctgcc acgcccgcca caacgtgcgc agctacctga actggtacca gcagaagccc       120
ggcaaggccc ccaagctgct gatctacgcc gccagcagcc agcagcgcgg cgtgcccagc       180
cgcttcagcg gcagcggcag cggcaccgac ttcaccttca ccatcagcag cctgcagccc       240
gaggacatcg ccacctacta ctgcctgcag agcttcggca cccccctgac cttcggcggc       300
ggcaccaagg tggagatcaa g                                                 321

<210>  33
<211>  321
<212>  DNA
<213>  066-7.17.2 L4

<400>  33
gacatccagc tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgcgtgacc        60
atcacctgcc acgcccgcca caacgtgcgc agctacctga actggtaccg ccagaagccc       120
ggcaaggtgc ccaagctgct gatctacgcc gccagcagcc agcagcgcgg cgtgcccagc       180
cgcttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc       240
gaggacgtgg ccacctacta cggcctgcag agcttcggca cccccctgac cttcggcggc       300
ggcaccaagg tggagatcaa g                                                 321

<210>  34
<211>  321
<212>  DNA
<213>  066-7.17.2 L5

<400>  34
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgcgtgacc        60
atcacctgcc acgcccgcca caacgtgcgc agctacctga actggtacca gcagaagccc       120
ggcaaggccc ccaagctgct gatctacgcc gccagcagcc agcagcgcgg cgtgcccagc       180
cgcttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc       240
gaggacttcg ccacctacta ctgcctgcag agcttcggca cccccctgac cttcggcggc       300
ggcaccaagg tggagatcaa g                                                 321

<210>  35
<211>  42
<212>  PRT
<213>  Aβ1-42

<400>  35
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      
Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          
Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          

<210>  36
<211>  16
<212>  PRT
<213>  Aβ1-16

<400>  36
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      

<210>  37
<211>  17
<212>  PRT
<213>  Aβ14-29

<400>  37
His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly 
1               5                   10                  15      
Ala 
    

<210>  38
<211>  112
<212>  PRT
<213>  066-P01阳性抗体重链可变区(heavy chain variable region of 066-P01 positive antibody )

<400>  38
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              
Ala Gln Ile Asn Ser Val Gly Asn Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         

<210>  39
<211>  112
<212>  PRT
<213>  066-P01阳性抗体轻链可变区(light chain variable region of 066-P01 positive antibody )

<400>  39
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ile Tyr Ser 
            20                  25                  30          
Asp Gly Asn Ala Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      
Thr His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  40
<211>  124
<212>  PRT
<213>  066-P02阳性抗体重链可变区(heavy chain variable region of 066-P02 positive antibody )

<400>  40
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Trp Phe Asp Gly Thr Lys Lys Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Gly Ile Gly Ala Arg Arg Gly Pro Tyr Tyr Met Asp 
            100                 105                 110         
Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 

<210>  41
<211>  107
<212>  PRT
<213>  066-P02阳性抗体轻链可变区(light chain variable region of 066-P02 positive antibody )

<400>  41
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210>  42
<211>  21
<212>  DNA
<213>  mIgGR

<400>  42
ctcagggaar tarccyttga c                                                  21

<210>  43
<211>  21
<212>  DNA
<213>  mIgKR

<400>  43
tcactgccat caatcttcca c                                                  21

<210>  44
<211>  18
<212>  DNA
<213>  M13F

<400>  44
tgtaaaacga cggccagt                                                      18

<210>  45
<211>  18
<212>  DNA
<213>  M13R

<400>  45
caggaaacag ctatgacc                                                      18

<210>  46
<211>  372
<212>  DNA
<213>  066-7.17.2 抗体的重链可变区(Heavy chain variable region of  066-7.17.2 antibody)

<400>  46
gaggtgcagc tggtggagag cggcggcggc ctggtgaagc ccggcggcag cctgaagctg        60
agctgcgccg ccagcggctt caccttcagc agctacggca tgcactgggt gaggcaggcc       120
cccgagaagg gcctggagtg ggtggccatg atctggtacg acggcaccaa gaagtactac       180
agcgacagcg tgaagggcag gttcaccatc agcagggaca acgccaagaa caccctgttc       240
ctgcagatga ccagcctgag gagcgaggac accgccatgt actactgcgc cagggacagg       300
ggcatcggca ccaggcacgg cccctacttc atggacgtgt ggggccaggg caccagcgtg       360
accgtgagca gc                                                           372

<210>  47
<211>  321
<212>  DNA
<213>  066-7.17.2 抗体的轻链可变区(Light chain variable region of  066-7.17.2 antibody)

<400>  47
gacatccaga tgaaccagag ccccagcagc ctgagcgcca gcctgggcga caccatcacc        60
atcacctgcc acgccaggca caacgtgagg agctacctga actggtacca gcagaagccc       120
ggcaacatcc ccaagctgct gatctacgcc gccagcagcc agcagagggg cgtgcccagc       180
aggttcagcg gcagcggcag cggcaccggc ttcaccctga ccatcagcag cctgcagccc       240
gaggacatcg ccacctacta ctgcctgcag agcttcggca cccccctgac cttcggcggc       300
ggcaccaagc tggagatcaa g                                                 321

<210>  48
<211>  124
<212>  PRT
<213>  066-7.17.2 抗体的重链可变区(Heavy chain variable region of  066-7.17.2 antibody)

<400>  48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Met Ile Trp Tyr Asp Gly Thr Lys Lys Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  
Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Gly Ile Gly Thr Arg His Gly Pro Tyr Phe Met Asp 
            100                 105                 110         
Val Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 

<210>  49
<211>  107
<212>  PRT
<213>  066-7.17.2 抗体的轻链可变区(Light chain variable region of  066-7.17.2 antibody)

<400>  49
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Thr Ile Thr Ile Thr Cys His Ala Arg His Asn Val Arg Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Gln Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Phe Gly Thr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  50
<211>  453
<212>  PRT
<213>  066-7.17.2鼠人嵌合抗体重链( heavy chain of 066-7.17.2 murine chimeric antibody)

<400>  50
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Met Ile Trp Tyr Asp Gly Thr Lys Lys Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  
Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Gly Ile Gly Thr Arg His Gly Pro Tyr Phe Met Asp 
            100                 105                 110         
Val Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             
Ser Leu Ser Pro Gly 
    450             

<210>  51
<211>  214
<212>  PRT
<213>  066-7.17.2鼠人嵌合抗体轻链( light chain of 066-7.17.2 murine chimeric antibody)

<400>  51
Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Thr Ile Thr Ile Thr Cys His Ala Arg His Asn Val Arg Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Gln Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Phe Gly Thr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

