                         SEQUENCE LISTING

<110>  Viscient Biosciences, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF 
       DISEASES OF THE LIVER

<130>  1428.2002PR

<150>  US 62/797017
<151>  2019-01-25

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Canonical Sequence

<400>  1

Met Ala Asn Tyr Thr Leu Ala Pro Glu Asp Glu Tyr Asp Val Leu Ile 
1               5                   10                  15      


Glu Gly Glu Leu Glu Ser Asp Glu Ala Glu Gln Cys Asp Lys Tyr Asp 
            20                  25                  30          


Ala Gln Ala Leu Ser Ala Gln Leu Val Pro Ser Leu Cys Ser Ala Val 
        35                  40                  45              


Phe Val Ile Gly Val Leu Asp Asn Leu Leu Val Val Leu Ile Leu Val 
    50                  55                  60                  


Lys Tyr Lys Gly Leu Lys Arg Val Glu Asn Ile Tyr Leu Leu Asn Leu 
65                  70                  75                  80  


Ala Val Ser Asn Leu Cys Phe Leu Leu Thr Leu Pro Phe Trp Ala His 
                85                  90                  95      


Ala Gly Gly Asp Pro Met Cys Lys Ile Leu Ile Gly Leu Tyr Phe Val 
            100                 105                 110         


Gly Leu Tyr Ser Glu Thr Phe Phe Asn Cys Leu Leu Thr Val Gln Arg 
        115                 120                 125             


Tyr Leu Val Phe Leu His Lys Gly Asn Phe Phe Ser Ala Arg Arg Arg 
    130                 135                 140                 


Val Pro Cys Gly Ile Ile Thr Ser Val Leu Ala Trp Val Thr Ala Ile 
145                 150                 155                 160 


Leu Ala Thr Leu Pro Glu Phe Val Val Tyr Lys Pro Gln Met Glu Asp 
                165                 170                 175     


Gln Lys Tyr Lys Cys Ala Phe Ser Arg Thr Pro Phe Leu Pro Ala Asp 
            180                 185                 190         


Glu Thr Phe Trp Lys His Phe Leu Thr Leu Lys Met Asn Ile Ser Val 
        195                 200                 205             


Leu Val Leu Pro Leu Phe Ile Phe Thr Phe Leu Tyr Val Gln Met Arg 
    210                 215                 220                 


Lys Thr Leu Arg Phe Arg Glu Gln Arg Tyr Ser Leu Phe Lys Leu Val 
225                 230                 235                 240 


Phe Ala Ile Met Val Val Phe Leu Leu Met Trp Ala Pro Tyr Asn Ile 
                245                 250                 255     


Ala Phe Phe Leu Ser Thr Phe Lys Glu His Phe Ser Leu Ser Asp Cys 
            260                 265                 270         


Lys Ser Ser Tyr Asn Leu Asp Lys Ser Val His Ile Thr Lys Leu Ile 
        275                 280                 285             


Ala Thr Thr His Cys Cys Ile Asn Pro Leu Leu Tyr Ala Phe Leu Asp 
    290                 295                 300                 


Gly Thr Phe Ser Lys Tyr Leu Cys Arg Cys Phe His Leu Arg Ser Asn 
305                 310                 315                 320 


Thr Pro Leu Gln Pro Arg Gly Gln Ser Ala Gln Gly Thr Ser Arg Glu 
                325                 330                 335     


Glu Pro Asp His Ser Thr Glu Val 
            340                 


<210>  2
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Canonical Sequence

<400>  2

Met Ile Tyr Thr Arg Phe Leu Lys Gly Ser Leu Lys Met Ala Asn Tyr 
1               5                   10                  15      


Thr Leu Ala Pro Glu Asp Glu Tyr Asp Val Leu Ile Glu Gly Glu Leu 
            20                  25                  30          


Glu Ser Asp Glu Ala Glu Gln Cys Asp Lys Tyr Asp Ala Gln Ala Leu 
        35                  40                  45              


Ser Ala Gln Leu Val Pro Ser Leu Cys Ser Ala Val Phe Val Ile Gly 
    50                  55                  60                  


Val Leu Asp Asn Leu Leu Val Val Leu Ile Leu Val Lys Tyr Lys Gly 
65                  70                  75                  80  


Leu Lys Arg Val Glu Asn Ile Tyr Leu Leu Asn Leu Ala Val Ser Asn 
                85                  90                  95      


Leu Cys Phe Leu Leu Thr Leu Pro Phe Trp Ala His Ala Gly Gly Asp 
            100                 105                 110         


Pro Met Cys Lys Ile Leu Ile Gly Leu Tyr Phe Val Gly Leu Tyr Ser 
        115                 120                 125             


Glu Thr Phe Phe Asn Cys Leu Leu Thr Val Gln Arg Tyr Leu Val Phe 
    130                 135                 140                 


Leu His Lys Gly Asn Phe Phe Ser Ala Arg Arg Arg Val Pro Cys Gly 
145                 150                 155                 160 


Ile Ile Thr Ser Val Leu Ala Trp Val Thr Ala Ile Leu Ala Thr Leu 
                165                 170                 175     


Pro Glu Phe Val Val Tyr Lys Pro Gln Met Glu Asp Gln Lys Tyr Lys 
            180                 185                 190         


Cys Ala Phe Ser Arg Thr Pro Phe Leu Pro Ala Asp Glu Thr Phe Trp 
        195                 200                 205             


Lys His Phe Leu Thr Leu Lys Met Asn Ile Ser Val Leu Val Leu Pro 
    210                 215                 220                 


Leu Phe Ile Phe Thr Phe Leu Tyr Val Gln Met Arg Lys Thr Leu Arg 
225                 230                 235                 240 


Phe Arg Glu Gln Arg Tyr Ser Leu Phe Lys Leu Val Phe Ala Ile Met 
                245                 250                 255     


Val Val Phe Leu Leu Met Trp Ala Pro Tyr Asn Ile Ala Phe Phe Leu 
            260                 265                 270         


Ser Thr Phe Lys Glu His Phe Ser Leu Ser Asp Cys Lys Ser Ser Tyr 
        275                 280                 285             


Asn Leu Asp Lys Ser Val His Ile Thr Lys Leu Ile Ala Thr Thr His 
    290                 295                 300                 


Cys Cys Ile Asn Pro Leu Leu Tyr Ala Phe Leu Asp Gly Thr Phe Ser 
305                 310                 315                 320 


Lys Tyr Leu Cys Arg Cys Phe His Leu Arg Ser Asn Thr Pro Leu Gln 
                325                 330                 335     


Pro Arg Gly Gln Ser Ala Gln Gly Thr Ser Arg Glu Glu Pro Asp His 
            340                 345                 350         


Ser Thr Glu Val 
        355     


<210>  3
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  3

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe Leu Phe Leu Leu His Arg Asp Val Ser 
            20                  25                  30          


Ser Arg Glu Glu Ala Thr Glu Lys Pro Trp Leu Lys Ser Leu Val Ser 
        35                  40                  45              


Arg Lys Asp His Val Leu Asp Leu Met Leu Glu Ala Met Asn Asn Leu 
    50                  55                  60                  


Arg Asp Ser Met Pro Lys Leu Gln Ile Arg Ala Pro Glu Ala Gln Gln 
65                  70                  75                  80  


Thr Leu Phe Ser Ile Asn Gln Ser Cys Leu Pro Gly Phe Tyr Thr Pro 
                85                  90                  95      


Ala Glu Leu Lys Pro Phe Trp Glu Arg Pro Pro Gln Asp Pro Asn Ala 
            100                 105                 110         


Pro Gly Ala Asp Gly Lys Ala Phe Gln Lys Ser Lys Trp Thr Pro Leu 
        115                 120                 125             


Glu Thr Gln Glu Lys Glu Glu Gly Tyr Lys Lys His Cys Phe Asn Ala 
    130                 135                 140                 


Phe Ala Ser Asp Arg Ile Ser Leu Gln Arg Ser Leu Gly Pro Asp Thr 
145                 150                 155                 160 


Arg Pro Pro Glu Cys Val Asp Gln Lys Phe Arg Arg Cys Pro Pro Leu 
                165                 170                 175     


Ala Thr Thr Ser Val Ile Ile Val Phe His Asn Glu Ala Trp Ser Thr 
            180                 185                 190         


Leu Leu Arg Thr Val Tyr Ser Val Leu His Thr Thr Pro Ala Ile Leu 
        195                 200                 205             


Leu Lys Glu Ile Ile Leu Val Asp Asp Ala Ser Thr Glu Glu His Leu 
    210                 215                 220                 


Lys Glu Lys Leu Glu Gln Tyr Val Lys Gln Leu Gln Val Val Arg Val 
225                 230                 235                 240 


Val Arg Gln Glu Glu Arg Lys Gly Leu Ile Thr Ala Arg Leu Leu Gly 
                245                 250                 255     


Ala Ser Val Ala Gln Ala Glu Val Leu Thr Phe Leu Asp Ala His Cys 
            260                 265                 270         


Glu Cys Phe His Gly Trp Leu Glu Pro Leu Leu Ala Arg Ile Ala Glu 
        275                 280                 285             


Asp Lys Thr Val Val Val Ser Pro Asp Ile Val Thr Ile Asp Leu Asn 
    290                 295                 300                 


Thr Phe Glu Phe Ala Lys Pro Val Gln Arg Gly Arg Val His Ser Arg 
305                 310                 315                 320 


Gly Asn Phe Asp Trp Ser Leu Thr Phe Gly Trp Glu Thr Leu Pro Pro 
                325                 330                 335     


His Glu Lys Gln Arg Arg Lys Asp Glu Thr Tyr Pro Ile Lys Ser Pro 
            340                 345                 350         


Thr Phe Ala Gly Gly Leu Phe Ser Ile Ser Lys Ser Tyr Phe Glu His 
        355                 360                 365             


Ile Gly Thr Tyr Asp Asn Gln Met Glu Ile Trp Gly Gly Glu Asn Val 
    370                 375                 380                 


Glu Met Ser Phe Arg Val Trp Gln Cys Gly Gly Gln Leu Glu Ile Ile 
385                 390                 395                 400 


Pro Cys Ser Val Val Gly His Val Phe Arg Thr Lys Ser Pro His Thr 
                405                 410                 415     


Phe Pro Lys Gly Thr Ser Val Ile Ala Arg Asn Gln Val Arg Leu Ala 
            420                 425                 430         


Glu Val Trp Met Asp Ser Tyr Lys Lys Ile Phe Tyr Arg Arg Asn Leu 
        435                 440                 445             


Gln Ala Ala Lys Met Ala Gln Glu Lys Ser Phe Gly Asp Ile Ser Glu 
    450                 455                 460                 


Arg Leu Gln Leu Arg Glu Gln Leu His Cys His Asn Phe Ser Trp Tyr 
465                 470                 475                 480 


Leu His Asn Val Tyr Pro Glu Met Phe Val Pro Asp Leu Thr Pro Thr 
                485                 490                 495     


Phe Tyr Gly Ala Ile Lys Asn Leu Gly Thr Asn Gln Cys Leu Asp Val 
            500                 505                 510         


Gly Glu Asn Asn Arg Gly Gly Lys Pro Leu Ile Met Tyr Ser Cys His 
        515                 520                 525             


Gly Leu Gly Gly Asn Gln Tyr Phe Glu Tyr Thr Thr Gln Arg Asp Leu 
    530                 535                 540                 


Arg His Asn Ile Ala Lys Gln Leu Cys Leu His Val Ser Lys Gly Ala 
545                 550                 555                 560 


Leu Gly Leu Gly Ser Cys His Phe Thr Gly Lys Asn Ser Gln Val Pro 
                565                 570                 575     


Lys Asp Glu Glu Trp Glu Leu Ala Gln Asp Gln Leu Ile Arg Asn Ser 
            580                 585                 590         


Gly Ser Gly Thr Cys Leu Thr Ser Gln Asp Lys Lys Pro Ala Met Ala 
        595                 600                 605             


Pro Cys Asn Pro Ser Asp Pro His Gln Leu Trp Leu Phe Val 
    610                 615                 620         


<210>  4
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  4

Met Gly Ala Ala Gly Ser Ser Ala Leu Ala Arg Phe Val Leu Leu Ala 
1               5                   10                  15      


Gln Ser Arg Pro Gly Trp Leu Gly Val Ala Ala Leu Gly Leu Thr Ala 
            20                  25                  30          


Val Ala Leu Gly Ala Val Ala Trp Arg Arg Ala Trp Pro Thr Arg Arg 
        35                  40                  45              


Arg Arg Leu Leu Gln Gln Val Gly Thr Val Ala Gln Leu Trp Ile Tyr 
    50                  55                  60                  


Pro Val Lys Ser Cys Lys Gly Val Pro Val Ser Glu Ala Glu Cys Thr 
65                  70                  75                  80  


Ala Met Gly Leu Arg Ser Gly Asn Leu Arg Asp Arg Phe Trp Leu Val 
                85                  90                  95      


Ile Asn Gln Glu Gly Asn Met Val Thr Ala Arg Gln Glu Pro Arg Leu 
            100                 105                 110         


Val Leu Ile Ser Leu Thr Cys Asp Gly Asp Thr Leu Thr Leu Ser Ala 
        115                 120                 125             


Ala Tyr Thr Lys Asp Leu Leu Leu Pro Ile Lys Thr Pro Thr Thr Asn 
    130                 135                 140                 


Ala Val His Lys Cys Arg Val His Gly Leu Glu Ile Glu Gly Arg Asp 
145                 150                 155                 160 


Cys Gly Glu Ala Thr Ala Gln Trp Ile Thr Ser Phe Leu Lys Ser Gln 
                165                 170                 175     


Pro Tyr Arg Leu Val His Phe Glu Pro His Met Arg Pro Arg Arg Pro 
            180                 185                 190         


His Gln Ile Ala Asp Leu Phe Arg Pro Lys Asp Gln Ile Ala Tyr Ser 
        195                 200                 205             


Asp Thr Ser Pro Phe Leu Ile Leu Ser Glu Ala Ser Leu Ala Asp Leu 
    210                 215                 220                 


Asn Ser Arg Leu Glu Lys Lys Val Lys Ala Thr Asn Phe Arg Pro Asn 
225                 230                 235                 240 


Ile Val Ile Ser Gly Cys Asp Val Tyr Ala Glu Asp Ser Trp Asp Glu 
                245                 250                 255     


Leu Leu Ile Gly Asp Val Glu Leu Lys Arg Val Met Ala Cys Ser Arg 
            260                 265                 270         


Cys Ile Leu Thr Thr Val Asp Pro Asp Thr Gly Val Met Ser Arg Lys 
        275                 280                 285             


Glu Pro Leu Glu Thr Leu Lys Ser Tyr Arg Gln Cys Asp Pro Ser Glu 
    290                 295                 300                 


Arg Lys Leu Tyr Gly Lys Ser Pro Leu Phe Gly Gln Tyr Phe Val Leu 
305                 310                 315                 320 


Glu Asn Pro Gly Thr Ile Lys Val Gly Asp Pro Val Tyr Leu Leu Gly 
                325                 330                 335     


Gln 
    


<210>  5
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Sequence

<400>  5

Met Gly Lys Pro Ala Arg Lys Gly Cys Glu Trp Lys Arg Phe Leu Lys 
1               5                   10                  15      


Asn Asn Trp Val Leu Leu Ser Thr Val Ala Ala Val Val Leu Gly Ile 
            20                  25                  30          


Thr Thr Gly Val Leu Val Arg Glu His Ser Asn Leu Ser Thr Leu Glu 
        35                  40                  45              


Lys Phe Tyr Phe Ala Phe Pro Gly Glu Ile Leu Met Arg Met Leu Lys 
    50                  55                  60                  


Leu Ile Ile Leu Pro Leu Ile Ile Ser Ser Met Ile Thr Gly Val Ala 
65                  70                  75                  80  


Ala Leu Asp Ser Asn Val Ser Gly Lys Ile Gly Leu Arg Ala Val Val 
                85                  90                  95      


Tyr Tyr Phe Cys Thr Thr Leu Ile Ala Val Ile Leu Gly Ile Val Leu 
            100                 105                 110         


Val Val Ser Ile Lys Pro Gly Val Thr Gln Lys Val Gly Glu Ile Ala 
        115                 120                 125             


Arg Thr Gly Ser Thr Pro Glu Val Ser Thr Val Asp Ala Met Leu Asp 
    130                 135                 140                 


Leu Ile Arg Asn Met Phe Pro Glu Asn Leu Val Gln Ala Cys Phe Gln 
145                 150                 155                 160 


Gln Tyr Lys Thr Lys Arg Glu Glu Val Lys Pro Pro Ser Asp Pro Glu 
                165                 170                 175     


Met Asn Met Thr Glu Glu Ser Phe Thr Ala Val Met Thr Thr Ala Ile 
            180                 185                 190         


Ser Lys Asn Lys Thr Lys Glu Tyr Lys Ile Val Gly Met Tyr Ser Asp 
        195                 200                 205             


Gly Ile Asn Val Leu Gly Leu Ile Val Phe Cys Leu Val Phe Gly Leu 
    210                 215                 220                 


Val Ile Gly Lys Met Gly Glu Lys Gly Gln Ile Leu Val Asp Phe Phe 
225                 230                 235                 240 


Asn Ala Leu Ser Asp Ala Thr Met Lys Ile Val Gln Ile Ile Met Cys 
                245                 250                 255     


Tyr Met Pro Leu Gly Ile Leu Phe Leu Ile Ala Gly Lys Ile Ile Glu 
            260                 265                 270         


Val Glu Asp Trp Glu Ile Phe Arg Lys Leu Gly Leu Tyr Met Ala Thr 
        275                 280                 285             


Val Leu Thr Gly Leu Ala Ile His Ser Ile Val Ile Leu Pro Leu Ile 
    290                 295                 300                 


Tyr Phe Ile Val Val Arg Lys Asn Pro Phe Arg Phe Ala Met Gly Met 
305                 310                 315                 320 


Ala Gln Ala Leu Leu Thr Ala Leu Met Ile Ser Ser Ser Ser Ala Thr 
                325                 330                 335     


Leu Pro Val Thr Phe Arg Cys Ala Glu Glu Asn Asn Gln Val Asp Lys 
            340                 345                 350         


Arg Ile Thr Arg Phe Val Leu Pro Val Gly Ala Thr Ile Asn Met Asp 
        355                 360                 365             


Gly Thr Ala Leu Tyr Glu Ala Val Ala Ala Val Phe Ile Ala Gln Leu 
    370                 375                 380                 


Asn Asp Leu Asp Leu Gly Ile Gly Gln Ile Ile Thr Ile Ser Ile Thr 
385                 390                 395                 400 


Ala Thr Ser Ala Ser Ile Gly Ala Ala Gly Val Pro Gln Ala Gly Leu 
                405                 410                 415     


Val Thr Met Val Ile Val Leu Ser Ala Val Gly Leu Pro Ala Glu Asp 
            420                 425                 430         


Val Thr Leu Ile Ile Ala Val Asp Trp Leu Leu Asp Arg Phe Arg Thr 
        435                 440                 445             


Met Val Asn Val Leu Gly Asp Ala Phe Gly Thr Gly Ile Val Glu Lys 
    450                 455                 460                 


Leu Ser Lys Lys Glu Leu Glu Gln Met Asp Val Ser Ser Glu Val Asn 
465                 470                 475                 480 


Ile Val Asn Pro Phe Ala Leu Glu Ser Thr Ile Leu Asp Asn Glu Asp 
                485                 490                 495     


Ser Asp Thr Lys Lys Ser Tyr Val Asn Gly Gly Phe Ala Val Asp Lys 
            500                 505                 510         


Ser Asp Thr Ile Ser Phe Thr Gln Thr Ser Gln Phe 
        515                 520                 


