                         SEQUENCE LISTING

<110>  Millennium Pharmaceuticals, Inc.
 
<120>  ANTI-CD38 BINDING DOMAINS

<130>  101588-5011-WO

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Ser Thr Gly Phe Trp Ser Gly Asn Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  2

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  3

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  4

Ala Arg Gly Pro Ser Thr Gly Phe Trp Ser Gly Asn Tyr Phe Asp Tyr 
1               5                   10                  15      


<210>  5
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  5

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Phe Tyr Pro Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala 
        35                  40                  45              


Leu Ile Tyr Ala Thr Asn Asn Lys Tyr Ser Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Leu Ser Arg Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Leu Val Tyr Tyr Asp Gly 
                85                  90                  95      


Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  6

Thr Gly Ala Val Thr Ser Gly Phe Tyr 
1               5                   


<210>  7
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  7

Ala Thr Asn 
1           


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  8

Leu Val Tyr Tyr Asp Gly Ala Trp 
1               5               


<210>  9
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  9

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Ser Asn Tyr Phe Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  10

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  11

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  12
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  12

Ala Arg Glu His Ser Asn Tyr Phe Tyr Gly Met Asp Val 
1               5                   10              


<210>  13
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  13

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 
                85                  90                  95      


Ser Gly Ser Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  14

Ser Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  15
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  15

Gly Asn Ser 
1           


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  16

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Gly 
1               5                   10      


<210>  17
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  17

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Gly Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Glu Thr Ser Phe Gly Leu Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  18

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  19

Ile Ser Gly Ser Gly Gly Gly Thr 
1               5               


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  20

Ala Arg Glu Gly Glu Thr Ser Phe Gly Leu Asp Val 
1               5                   10          


<210>  21
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  21

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 
                85                  90                  95      


Ser Val Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  22

Ser Ser Asn Ile Gly Gly Asn Tyr 
1               5               


<210>  23
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  23

Arg Asn Asn 
1           


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  24

Gln Ser Tyr Asp Ser Ser Leu Ser Val Ser 
1               5                   10  


<210>  25
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser 
            20                  25                  30          


Gly Phe Tyr Pro Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Ala Leu Ile Tyr Ala Thr Asn Asn Lys Tyr Ser Trp Thr Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Leu Ser Arg 
65                  70                  75                  80  


Val Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Leu Val Tyr Tyr Asp 
                85                  90                  95      


Gly Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  26
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting reference molecule

<400>  26

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Met Trp Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Asn Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Ser Met Ile Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Ser Leu Val Thr Val Ser Ser 
        115                 


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting reference molecule

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  28
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 Homo sapiens

<400>  28

Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 
            20                  25                  30          


Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              


Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 
    50                  55                  60                  


Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      


His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         


Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
        115                 120                 125             


Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 
    130                 135                 140                 


Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 
145                 150                 155                 160 


Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
                165                 170                 175     


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 
            180                 185                 190         


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
        195                 200                 205             


Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly Ser 
    210                 215                 220                 


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 
225                 230                 235                 240 


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
                245                 250                 255     


Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
            260                 265                 270         


Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
        275                 280                 285             


Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
    290                 295                 300 


<210>  29
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 Homo sapiens extracellular domain

<400>  29

Val Pro Arg Trp Arg Gln Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg 
1               5                   10                  15      


Phe Pro Glu Thr Val Leu Ala Arg Cys Val Lys Tyr Thr Glu Ile His 
            20                  25                  30          


Pro Glu Met Arg His Val Asp Cys Gln Ser Val Trp Asp Ala Phe Lys 
        35                  40                  45              


Gly Ala Phe Ile Ser Lys His Pro Cys Asn Ile Thr Glu Glu Asp Tyr 
    50                  55                  60                  


Gln Pro Leu Met Lys Leu Gly Thr Gln Thr Val Pro Cys Asn Lys Ile 
65                  70                  75                  80  


Leu Leu Trp Ser Arg Ile Lys Asp Leu Ala His Gln Phe Thr Gln Val 
                85                  90                  95      


Gln Arg Asp Met Phe Thr Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala 
            100                 105                 110         


Asp Asp Leu Thr Trp Cys Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr 
        115                 120                 125             


Gln Ser Cys Pro Asp Trp Arg Lys Asp Cys Ser Asn Asn Pro Val Ser 
    130                 135                 140                 


Val Phe Trp Lys Thr Val Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp 
145                 150                 155                 160 


Val Val His Val Met Leu Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys 
                165                 170                 175     


Asn Ser Thr Phe Gly Ser Val Glu Val His Asn Leu Gln Pro Glu Lys 
            180                 185                 190         


Val Gln Thr Leu Glu Ala Trp Val Ile His Gly Gly Arg Glu Asp Ser 
        195                 200                 205             


Arg Asp Leu Cys Gln Asp Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile 
    210                 215                 220                 


Ser Lys Arg Asn Ile Gln Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp 
225                 230                 235                 240 


Lys Phe Leu Gln Cys Val Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser 
                245                 250                 255     


Glu Ile 
        


<210>  30
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 Macaca fascicularis

<400>  30

Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Val Cys Leu Gly Val Cys Leu Leu Val 
            20                  25                  30          


Leu Leu Ile Leu Val Val Val Val Ala Val Val Leu Pro Arg Trp Arg 
        35                  40                  45              


Gln Gln Trp Ser Gly Ser Gly Thr Thr Ser Arg Phe Pro Glu Thr Val 
    50                  55                  60                  


Leu Ala Arg Cys Val Lys Tyr Thr Glu Val His Pro Glu Met Arg His 
65                  70                  75                  80  


Val Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser 
                85                  90                  95      


Lys Tyr Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Val Lys 
            100                 105                 110         


Leu Gly Thr Gln Thr Val Pro Cys Asn Lys Thr Leu Leu Trp Ser Arg 
        115                 120                 125             


Ile Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe 
    130                 135                 140                 


Thr Leu Glu Asp Met Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp 
145                 150                 155                 160 


Cys Gly Glu Phe Asn Thr Phe Glu Ile Asn Tyr Gln Ser Cys Pro Asp 
                165                 170                 175     


Trp Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr 
            180                 185                 190         


Val Ser Arg Arg Phe Ala Glu Thr Ala Cys Gly Val Val His Val Met 
        195                 200                 205             


Leu Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly 
    210                 215                 220                 


Ser Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Ala Leu Glu 
225                 230                 235                 240 


Ala Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln 
                245                 250                 255     


Asp Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile 
            260                 265                 270         


Arg Phe Phe Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys 
        275                 280                 285             


Val Lys Asn Pro Glu Asp Ser Ser Cys Leu Ser Gly Ile 
    290                 295                 300     


<210>  31
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 Macaca fascicularis extracellular domain

<400>  31

Leu Pro Arg Trp Arg Gln Gln Trp Ser Gly Ser Gly Thr Thr Ser Arg 
1               5                   10                  15      


Phe Pro Glu Thr Val Leu Ala Arg Cys Val Lys Tyr Thr Glu Val His 
            20                  25                  30          


Pro Glu Met Arg His Val Asp Cys Gln Ser Val Trp Asp Ala Phe Lys 
        35                  40                  45              


Gly Ala Phe Ile Ser Lys Tyr Pro Cys Asn Ile Thr Glu Glu Asp Tyr 
    50                  55                  60                  


Gln Pro Leu Val Lys Leu Gly Thr Gln Thr Val Pro Cys Asn Lys Thr 
65                  70                  75                  80  


Leu Leu Trp Ser Arg Ile Lys Asp Leu Ala His Gln Phe Thr Gln Val 
                85                  90                  95      


Gln Arg Asp Met Phe Thr Leu Glu Asp Met Leu Leu Gly Tyr Leu Ala 
            100                 105                 110         


Asp Asp Leu Thr Trp Cys Gly Glu Phe Asn Thr Phe Glu Ile Asn Tyr 
        115                 120                 125             


Gln Ser Cys Pro Asp Trp Arg Lys Asp Cys Ser Asn Asn Pro Val Ser 
    130                 135                 140                 


Val Phe Trp Lys Thr Val Ser Arg Arg Phe Ala Glu Thr Ala Cys Gly 
145                 150                 155                 160 


Val Val His Val Met Leu Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys 
                165                 170                 175     


Asn Ser Thr Phe Gly Ser Val Glu Val His Asn Leu Gln Pro Glu Lys 
            180                 185                 190         


Val Gln Ala Leu Glu Ala Trp Val Ile His Gly Gly Arg Glu Asp Ser 
        195                 200                 205             


Arg Asp Leu Cys Gln Asp Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile 
    210                 215                 220                 


Ser Lys Arg Asn Ile Arg Phe Phe Cys Lys Asn Ile Tyr Arg Pro Asp 
225                 230                 235                 240 


Lys Phe Leu Gln Cys Val Lys Asn Pro Glu Asp Ser Ser Cys Leu Ser 
                245                 250                 255     


Gly Ile 
        


<210>  32
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  32

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  33
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  33

Gly Gly Ser 
1           


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  34

Gly Gly Gly Ser 
1               


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  35

Gly Gly Gly Gly Ser 
1               5   


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  36

Gly Gly Gly Gly Ser Gly Gly Gly 
1               5               


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  37

Gly Gly Ser Gly Gly Gly Gly 
1               5           


<210>  38
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  38

Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Ser 
        


<210>  39
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 constant region

<400>  39

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  40
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 targeting moiety-SLTA

<400>  40

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ser Val Leu 
            260                 265                 270         


Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile 
        275                 280                 285             


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr Trp 
    290                 295                 300                 


Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asn 
305                 310                 315                 320 


Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
                325                 330                 335     


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu 
            340                 345                 350         


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Gly 
        355                 360                 365             


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
                405                 410                 415     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            420                 425                 430         


Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly 
        435                 440                 445             


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
    450                 455                 460                 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
465                 470                 475                 480 


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
                485                 490                 495     


Thr Ala Val Tyr Tyr Cys Ala Arg Glu His Ser Asn Tyr Phe Tyr Gly 
            500                 505                 510         


Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        515                 520                 525     


<210>  41
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 targeting moiety-SLTA

<400>  41

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Ser Val Leu 
            260                 265                 270         


Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile 
        275                 280                 285             


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Asn Tyr Val Tyr Trp 
    290                 295                 300                 


Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Arg Asn 
305                 310                 315                 320 


Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
                325                 330                 335     


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu 
            340                 345                 350         


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Val Ser Val 
        355                 360                 365             


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Gly Ser 
    370                 375                 380                 


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
385                 390                 395                 400 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
                405                 410                 415     


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            420                 425                 430         


Ser Ala Ile Ser Gly Ser Gly Gly Gly Thr Phe Tyr Ala Asp Ser Val 
        435                 440                 445             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    450                 455                 460                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
465                 470                 475                 480 


Ala Arg Glu Gly Glu Thr Ser Phe Gly Leu Asp Val Trp Gly Gln Gly 
                485                 490                 495     


Thr Leu Val Thr Val Ser Ser 
            500             


<210>  42
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 targeting moiety-SLTA

<400>  42

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu 
            260                 265                 270         


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile 
        275                 280                 285             


Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp 
    290                 295                 300                 


Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr 
305                 310                 315                 320 


Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val 
                325                 330                 335     


Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser 
            340                 345                 350         


Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gly Pro 
        355                 360                 365             


Ser Thr Gly Phe Trp Ser Gly Asn Tyr Phe Asp Tyr Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Thr Val Val 
385                 390                 395                 400 


Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Glu Thr Val Thr Leu 
                405                 410                 415     


Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Phe Tyr Pro Asn 
            420                 425                 430         


Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr Ala 
        435                 440                 445             


Thr Asn Asn Lys Tyr Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Asp Lys Ala Ala Leu Thr Leu Ser Arg Val Gln Pro Glu Asp 
465                 470                 475                 480 


Glu Ala Asp Tyr Tyr Cys Leu Val Tyr Tyr Asp Gly Ala Trp Val Phe 
                485                 490                 495     


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            500                 505     


<210>  43
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 targeting moiety-SLTA

<400>  43

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ile Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Ile Leu Gly Phe Asp Phe Thr Leu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Ala Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Ala Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Ser His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Gln Val Gln Leu 
            260                 265                 270         


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile 
        275                 280                 285             


Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp 
    290                 295                 300                 


Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr 
305                 310                 315                 320 


Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val 
                325                 330                 335     


Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser 
            340                 345                 350         


Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gly Pro 
        355                 360                 365             


Ser Thr Gly Phe Trp Ser Gly Asn Tyr Phe Asp Tyr Trp Gly Gln Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
385                 390                 395                 400 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                405                 410                 415     


Ile Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly Phe Tyr Pro 
            420                 425                 430         


Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr 
        435                 440                 445             


Ala Thr Asn Asn Lys Tyr Ser Trp Thr Pro Ala Arg Phe Ser Gly Ser 
    450                 455                 460                 


Leu Leu Gly Asp Lys Ala Ala Leu Thr Leu Ser Arg Val Gln Pro Glu 
465                 470                 475                 480 


Asp Glu Ala Asp Tyr Tyr Cys Leu Val Tyr Tyr Asp Gly Ala Trp Val 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            500                 505         


<210>  44
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38 targeting moiety-SLTA

<400>  44

Met Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp 
1               5                   10                  15      


Ser Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile 
            20                  25                  30          


Ser Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp 
        35                  40                  45              


Asn Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg 
    50                  55                  60                  


Phe Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr 
65                  70                  75                  80  


Gly Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe 
                85                  90                  95      


Ser His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp 
            100                 105                 110         


Ser Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly 
        115                 120                 125             


Met Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met 
    130                 135                 140                 


Ser His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu 
145                 150                 155                 160 


Arg Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln 
                165                 170                 175     


Arg Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val 
            180                 185                 190         


Met Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser 
        195                 200                 205             


Ser Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg 
    210                 215                 220                 


Ile Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile 
225                 230                 235                 240 


Leu Asn Cys His His His Ala Ser Ala Val Ala Ala Glu Phe Pro Lys 
                245                 250                 255     


Pro Ser Thr Pro Pro Gly Ser Ser Gly Gly Ala Pro Asp Ile Gln Met 
            260                 265                 270         


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        275                 280                 285             


Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Thr Trp Tyr 
    290                 295                 300                 


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Ser Gly Ala Thr 
305                 310                 315                 320 


Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
                325                 330                 335     


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            340                 345                 350         


Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Asn Pro Tyr Thr Phe Gly Gln 
        355                 360                 365             


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gln Val Gln Leu 
    370                 375                 380                 


Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln Thr Leu Ser Leu 
385                 390                 395                 400 


Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr Gly Val His Trp 
                405                 410                 415     


Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile Gly Val Met Trp 
            420                 425                 430         


Arg Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met Ser Arg Leu Asn 
        435                 440                 445             


Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Arg Leu Ser Ser 
    450                 455                 460                 


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys Ser Met Ile 
465                 470                 475                 480 


Thr Thr Gly Phe Val Met Asp Ser Trp Gly Gln Gly Ser Leu Val Thr 
                485                 490                 495     


Val Ser Ser 
            


<210>  45
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 D265A constant region

<400>  45

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  46
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 N297A constant region

<400>  46

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  47
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 constant region

<400>  47

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  48
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG3 constant region

<400>  48

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  49
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 constant region (Wild Type)

<400>  49

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Pro Gly Lys 
                325         


<210>  50
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 constant region (S241P hinge mutant)

<400>  50

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Pro Gly Lys 
                325         


<210>  51
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human kappa light chain

<400>  51

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  52
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human lambda light chain

<400>  52

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  53
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  53

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Gly Pro Tyr Tyr Leu Tyr Gly Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  54

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  55

Ile Ser Ser Ser Ser Ser Tyr Ile 
1               5               


<210>  56
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  56

Ala Thr Glu Gly Pro Tyr Tyr Leu Tyr Gly Phe Asp Ile 
1               5                   10              


<210>  57
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  57

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Thr Leu 
                85                  90                  95      


Ser Gly Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  58

Ser Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  59
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  59

Gly Asn Ser 
1           


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  60

Gln Ser Tyr Asp Asn Thr Leu Ser Gly Val 
1               5                   10  


<210>  61
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  61

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Phe His Asp Ser Ser Gly Tyr Tyr Phe Gly His 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  62

Gly Phe Thr Phe Asp Asp Tyr Gly 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  63

Ile Asn Trp Asn Gly Gly Ser Thr 
1               5               


<210>  64
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  64

Ala Arg Gly Gly Leu Phe His Asp Ser Ser Gly Tyr Tyr Phe Gly His 
1               5                   10                  15      


<210>  65
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  65

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Ser 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Asp Asn Leu 
                85                  90                  95      


Ser Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  66

Ser Ser Asn Ile Gly Asn Ser Tyr 
1               5               


<210>  67
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  67

Arg Asn Asn 
1           


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD38-Targeting Moiety

<400>  68

Ser Ala Trp Asp Asp Asn Leu Ser Val 
1               5                   


