                         SEQUENCE LISTING

<110>  Path Therapeutics, Inc.
       Kurrasch, Deborah
       Ibhazehiebo, Kingsley
 
<120>  METHODS OF TREATING EPILEPSY VIA PHOSPHODIESTERASE 4 (PDE4) 
       INHIBITION

<130>  PATH-001WO

<150>  US 62/796,002
<151>  2019-01-23

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  886
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Pro Pro Thr Val Pro Ser Glu Arg Ser Leu Ser Leu Ser Leu 
1               5                   10                  15      


Pro Gly Pro Arg Glu Gly Gln Ala Thr Leu Lys Pro Pro Pro Gln His 
            20                  25                  30          


Leu Trp Arg Gln Pro Arg Thr Pro Ile Arg Ile Gln Gln Arg Gly Tyr 
        35                  40                  45              


Ser Asp Ser Ala Glu Arg Ala Glu Arg Glu Arg Gln Pro His Arg Pro 
    50                  55                  60                  


Ile Glu Arg Ala Asp Ala Met Asp Thr Ser Asp Arg Pro Gly Leu Arg 
65                  70                  75                  80  


Thr Thr Arg Met Ser Trp Pro Ser Ser Phe His Gly Thr Gly Thr Gly 
                85                  90                  95      


Ser Gly Gly Ala Gly Gly Gly Ser Ser Arg Arg Phe Glu Ala Glu Asn 
            100                 105                 110         


Gly Pro Thr Pro Ser Pro Gly Arg Ser Pro Leu Asp Ser Gln Ala Ser 
        115                 120                 125             


Pro Gly Leu Val Leu His Ala Gly Ala Ala Thr Ser Gln Arg Arg Glu 
    130                 135                 140                 


Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Met Ser Pro Lys Thr 
145                 150                 155                 160 


Met Ser Arg Asn Ser Ser Val Thr Ser Glu Ala His Ala Glu Asp Leu 
                165                 170                 175     


Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Ser Val Arg 
            180                 185                 190         


Ser Asn Phe Ser Leu Leu Thr Asn Val Pro Val Pro Ser Asn Lys Arg 
        195                 200                 205             


Ser Pro Leu Gly Gly Pro Thr Pro Val Cys Lys Ala Thr Leu Ser Glu 
    210                 215                 220                 


Glu Thr Cys Gln Gln Leu Ala Arg Glu Thr Leu Glu Glu Leu Asp Trp 
225                 230                 235                 240 


Cys Leu Glu Gln Leu Glu Thr Met Gln Thr Tyr Arg Ser Val Ser Glu 
                245                 250                 255     


Met Ala Ser His Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His 
            260                 265                 270         


Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Tyr Ile Ser 
        275                 280                 285             


Thr Thr Phe Leu Asp Lys Gln Asn Glu Val Glu Ile Pro Ser Pro Thr 
    290                 295                 300                 


Met Lys Glu Arg Glu Lys Gln Gln Ala Pro Arg Pro Arg Pro Ser Gln 
305                 310                 315                 320 


Pro Pro Pro Pro Pro Val Pro His Leu Gln Pro Met Ser Gln Ile Thr 
                325                 330                 335     


Gly Leu Lys Lys Leu Met His Ser Asn Ser Leu Asn Asn Ser Asn Ile 
            340                 345                 350         


Pro Arg Phe Gly Val Lys Thr Asp Gln Glu Glu Leu Leu Ala Gln Glu 
        355                 360                 365             


Leu Glu Asn Leu Asn Lys Trp Gly Leu Asn Ile Phe Cys Val Ser Asp 
    370                 375                 380                 


Tyr Ala Gly Gly Arg Ser Leu Thr Cys Ile Met Tyr Met Ile Phe Gln 
385                 390                 395                 400 


Glu Arg Asp Leu Leu Lys Lys Phe Arg Ile Pro Val Asp Thr Met Val 
                405                 410                 415     


Thr Tyr Met Leu Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr 
            420                 425                 430         


His Asn Ser Leu His Ala Ala Asp Val Leu Gln Ser Thr His Val Leu 
        435                 440                 445             


Leu Ala Thr Pro Ala Leu Asp Ala Val Phe Thr Asp Leu Glu Ile Leu 
    450                 455                 460                 


Ala Ala Leu Phe Ala Ala Ala Ile His Asp Val Asp His Pro Gly Val 
465                 470                 475                 480 


Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr 
                485                 490                 495     


Asn Asp Glu Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys 
            500                 505                 510         


Leu Leu Gln Glu Asp Asn Cys Asp Ile Phe Gln Asn Leu Ser Lys Arg 
        515                 520                 525             


Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Met Val Leu Ala Thr 
    530                 535                 540                 


Asp Met Ser Lys His Met Thr Leu Leu Ala Asp Leu Lys Thr Met Val 
545                 550                 555                 560 


Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr 
                565                 570                 575     


Ser Asp Arg Ile Gln Val Leu Arg Asn Met Val His Cys Ala Asp Leu 
            580                 585                 590         


Ser Asn Pro Thr Lys Pro Leu Glu Leu Tyr Arg Gln Trp Thr Asp Arg 
        595                 600                 605             


Ile Met Ala Glu Phe Phe Gln Gln Gly Asp Arg Glu Arg Glu Arg Gly 
    610                 615                 620                 


Met Glu Ile Ser Pro Met Cys Asp Lys His Thr Ala Ser Val Glu Lys 
625                 630                 635                 640 


Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr 
                645                 650                 655     


Trp Ala Asp Leu Val His Pro Asp Ala Gln Glu Ile Leu Asp Thr Leu 
            660                 665                 670         


Glu Asp Asn Arg Asp Trp Tyr Tyr Ser Ala Ile Arg Gln Ser Pro Ser 
        675                 680                 685             


Pro Pro Pro Glu Glu Glu Ser Arg Gly Pro Gly His Pro Pro Leu Pro 
    690                 695                 700                 


Asp Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu Glu Glu Glu Glu Glu 
705                 710                 715                 720 


Ile Ser Met Ala Gln Ile Pro Cys Thr Ala Gln Glu Ala Leu Thr Ala 
                725                 730                 735     


Gln Gly Leu Ser Gly Val Glu Glu Ala Leu Asp Ala Thr Ile Ala Trp 
            740                 745                 750         


Glu Ala Ser Pro Ala Gln Glu Ser Leu Glu Val Met Ala Gln Glu Ala 
        755                 760                 765             


Ser Leu Glu Ala Glu Leu Glu Ala Val Tyr Leu Thr Gln Gln Ala Gln 
    770                 775                 780                 


Ser Thr Gly Ser Ala Pro Val Ala Pro Asp Glu Phe Ser Ser Arg Glu 
785                 790                 795                 800 


Glu Phe Val Val Ala Val Ser His Ser Ser Pro Ser Ala Leu Ala Leu 
                805                 810                 815     


Gln Ser Pro Leu Leu Pro Ala Trp Arg Thr Leu Ser Val Ser Glu His 
            820                 825                 830         


Ala Pro Gly Leu Pro Gly Leu Pro Ser Thr Ala Ala Glu Val Glu Ala 
        835                 840                 845             


Gln Arg Glu His Gln Ala Ala Lys Arg Ala Cys Ser Ala Cys Ala Gly 
    850                 855                 860                 


Thr Phe Gly Glu Asp Thr Ser Ala Leu Pro Ala Pro Gly Gly Gly Gly 
865                 870                 875                 880 


Ser Gly Gly Asp Pro Thr 
                885     


<210>  2
<211>  860
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Arg Pro Arg Gly Leu Gly Arg Ile Pro Glu Leu Gln Leu Val 
1               5                   10                  15      


Ala Phe Pro Val Ala Val Ala Ala Glu Asp Glu Ala Phe Leu Pro Glu 
            20                  25                  30          


Pro Leu Ala Pro Arg Ala Pro Arg Arg Pro Arg Ser Pro Pro Ser Ser 
        35                  40                  45              


Pro Val Phe Phe Ala Ser Pro Ser Pro Thr Phe Arg Arg Arg Leu Arg 
    50                  55                  60                  


Leu Leu Arg Ser Cys Gln Asp Leu Gly Arg Gln Ala Trp Ala Gly Ala 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Asn Gly Pro Thr Pro Ser Pro Gly Arg Ser Pro 
                85                  90                  95      


Leu Asp Ser Gln Ala Ser Pro Gly Leu Val Leu His Ala Gly Ala Ala 
            100                 105                 110         


Thr Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr 
        115                 120                 125             


Asp Met Ser Pro Lys Thr Met Ser Arg Asn Ser Ser Val Thr Ser Glu 
    130                 135                 140                 


Ala His Ala Glu Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala 
145                 150                 155                 160 


Ser Leu Arg Ser Val Arg Ser Asn Phe Ser Leu Leu Thr Asn Val Pro 
                165                 170                 175     


Val Pro Ser Asn Lys Arg Ser Pro Leu Gly Gly Pro Thr Pro Val Cys 
            180                 185                 190         


Lys Ala Thr Leu Ser Glu Glu Thr Cys Gln Gln Leu Ala Arg Glu Thr 
        195                 200                 205             


Leu Glu Glu Leu Asp Trp Cys Leu Glu Gln Leu Glu Thr Met Gln Thr 
    210                 215                 220                 


Tyr Arg Ser Val Ser Glu Met Ala Ser His Lys Phe Lys Arg Met Leu 
225                 230                 235                 240 


Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln 
                245                 250                 255     


Val Ser Glu Tyr Ile Ser Thr Thr Phe Leu Asp Lys Gln Asn Glu Val 
            260                 265                 270         


Glu Ile Pro Ser Pro Thr Met Lys Glu Arg Glu Lys Gln Gln Ala Pro 
        275                 280                 285             


Arg Pro Arg Pro Ser Gln Pro Pro Pro Pro Pro Val Pro His Leu Gln 
    290                 295                 300                 


Pro Met Ser Gln Ile Thr Gly Leu Lys Lys Leu Met His Ser Asn Ser 
305                 310                 315                 320 


Leu Asn Asn Ser Asn Ile Pro Arg Phe Gly Val Lys Thr Asp Gln Glu 
                325                 330                 335     


Glu Leu Leu Ala Gln Glu Leu Glu Asn Leu Asn Lys Trp Gly Leu Asn 
            340                 345                 350         


Ile Phe Cys Val Ser Asp Tyr Ala Gly Gly Arg Ser Leu Thr Cys Ile 
        355                 360                 365             


Met Tyr Met Ile Phe Gln Glu Arg Asp Leu Leu Lys Lys Phe Arg Ile 
    370                 375                 380                 


Pro Val Asp Thr Met Val Thr Tyr Met Leu Thr Leu Glu Asp His Tyr 
385                 390                 395                 400 


His Ala Asp Val Ala Tyr His Asn Ser Leu His Ala Ala Asp Val Leu 
                405                 410                 415     


Gln Ser Thr His Val Leu Leu Ala Thr Pro Ala Leu Asp Ala Val Phe 
            420                 425                 430         


Thr Asp Leu Glu Ile Leu Ala Ala Leu Phe Ala Ala Ala Ile His Asp 
        435                 440                 445             


Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser 
    450                 455                 460                 


Glu Leu Ala Leu Met Tyr Asn Asp Glu Ser Val Leu Glu Asn His His 
465                 470                 475                 480 


Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Asp Asn Cys Asp Ile Phe 
                485                 490                 495     


Gln Asn Leu Ser Lys Arg Gln Arg Gln Ser Leu Arg Lys Met Val Ile 
            500                 505                 510         


Asp Met Val Leu Ala Thr Asp Met Ser Lys His Met Thr Leu Leu Ala 
        515                 520                 525             


Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val 
    530                 535                 540                 


Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Arg Asn Met 
545                 550                 555                 560 


Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Glu Leu Tyr 
                565                 570                 575     


Arg Gln Trp Thr Asp Arg Ile Met Ala Glu Phe Phe Gln Gln Gly Asp 
            580                 585                 590         


Arg Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His 
        595                 600                 605             


Thr Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val 
    610                 615                 620                 


His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln 
625                 630                 635                 640 


Glu Ile Leu Asp Thr Leu Glu Asp Asn Arg Asp Trp Tyr Tyr Ser Ala 
                645                 650                 655     


Ile Arg Gln Ser Pro Ser Pro Pro Pro Glu Glu Glu Ser Arg Gly Pro 
            660                 665                 670         


Gly His Pro Pro Leu Pro Asp Lys Phe Gln Phe Glu Leu Thr Leu Glu 
        675                 680                 685             


Glu Glu Glu Glu Glu Glu Ile Ser Met Ala Gln Ile Pro Cys Thr Ala 
    690                 695                 700                 


Gln Glu Ala Leu Thr Ala Gln Gly Leu Ser Gly Val Glu Glu Ala Leu 
705                 710                 715                 720 


Asp Ala Thr Ile Ala Trp Glu Ala Ser Pro Ala Gln Glu Ser Leu Glu 
                725                 730                 735     


Val Met Ala Gln Glu Ala Ser Leu Glu Ala Glu Leu Glu Ala Val Tyr 
            740                 745                 750         


Leu Thr Gln Gln Ala Gln Ser Thr Gly Ser Ala Pro Val Ala Pro Asp 
        755                 760                 765             


Glu Phe Ser Ser Arg Glu Glu Phe Val Val Ala Val Ser His Ser Ser 
    770                 775                 780                 


Pro Ser Ala Leu Ala Leu Gln Ser Pro Leu Leu Pro Ala Trp Arg Thr 
785                 790                 795                 800 


Leu Ser Val Ser Glu His Ala Pro Gly Leu Pro Gly Leu Pro Ser Thr 
                805                 810                 815     


Ala Ala Glu Val Glu Ala Gln Arg Glu His Gln Ala Ala Lys Arg Ala 
            820                 825                 830         


Cys Ser Ala Cys Ala Gly Thr Phe Gly Glu Asp Thr Ser Ala Leu Pro 
        835                 840                 845             


Ala Pro Gly Gly Gly Gly Ser Gly Gly Asp Pro Thr 
    850                 855                 860 


<210>  3
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Cys Pro Phe Pro Val Thr Thr Val Pro Leu Gly Gly Pro Thr Pro 
1               5                   10                  15      


Val Cys Lys Ala Thr Leu Ser Glu Glu Thr Cys Gln Gln Leu Ala Arg 
            20                  25                  30          


Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu Glu Gln Leu Glu Thr Met 
        35                  40                  45              


Gln Thr Tyr Arg Ser Val Ser Glu Met Ala Ser His Lys Phe Lys Arg 
    50                  55                  60                  


Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly 
65                  70                  75                  80  


Asn Gln Val Ser Glu Tyr Ile Ser Thr Thr Phe Leu Asp Lys Gln Asn 
                85                  90                  95      


Glu Val Glu Ile Pro Ser Pro Thr Met Lys Glu Arg Glu Lys Gln Gln 
            100                 105                 110         


Ala Pro Arg Pro Arg Pro Ser Gln Pro Pro Pro Pro Pro Val Pro His 
        115                 120                 125             


Leu Gln Pro Met Ser Gln Ile Thr Gly Leu Lys Lys Leu Met His Ser 
    130                 135                 140                 


Asn Ser Leu Asn Asn Ser Asn Ile Pro Arg Phe Gly Val Lys Thr Asp 
145                 150                 155                 160 


Gln Glu Glu Leu Leu Ala Gln Glu Leu Glu Asn Leu Asn Lys Trp Gly 
                165                 170                 175     


Leu Asn Ile Phe Cys Val Ser Asp Tyr Ala Gly Gly Arg Ser Leu Thr 
            180                 185                 190         


Cys Ile Met Tyr Met Ile Phe Gln Glu Arg Asp Leu Leu Lys Lys Phe 
        195                 200                 205             


Arg Ile Pro Val Asp Thr Met Val Thr Tyr Met Leu Thr Leu Glu Asp 
    210                 215                 220                 


His Tyr His Ala Asp Val Ala Tyr His Asn Ser Leu His Ala Ala Asp 
225                 230                 235                 240 


Val Leu Gln Ser Thr His Val Leu Leu Ala Thr Pro Ala Leu Asp Ala 
                245                 250                 255     


Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Leu Phe Ala Ala Ala Ile 
            260                 265                 270         


His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr 
        275                 280                 285             


Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Glu Ser Val Leu Glu Asn 
    290                 295                 300                 


His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Asp Asn Cys Asp 
305                 310                 315                 320 


Ile Phe Gln Asn Leu Ser Lys Arg Gln Arg Gln Ser Leu Arg Lys Met 
                325                 330                 335     


Val Ile Asp Met Val Leu Ala Thr Asp Met Ser Lys His Met Thr Leu 
            340                 345                 350         


Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser 
        355                 360                 365             


Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Arg 
    370                 375                 380                 


Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Glu 
385                 390                 395                 400 


Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Ala Glu Phe Phe Gln Gln 
                405                 410                 415     


Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp 
            420                 425                 430         


Lys His Thr Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr 
        435                 440                 445             


Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp 
    450                 455                 460                 


Ala Gln Glu Ile Leu Asp Thr Leu Glu Asp Asn Arg Asp Trp Tyr Tyr 
465                 470                 475                 480 


Ser Ala Ile Arg Gln Ser Pro Ser Pro Pro Pro Glu Glu Glu Ser Arg 
                485                 490                 495     


Gly Pro Gly His Pro Pro Leu Pro Asp Lys Phe Gln Phe Glu Leu Thr 
            500                 505                 510         


Leu Glu Glu Glu Glu Glu Glu Glu Ile Ser Met Ala Gln Ile Pro Cys 
        515                 520                 525             


Thr Ala Gln Glu Ala Leu Thr Ala Gln Gly Leu Ser Gly Val Glu Glu 
    530                 535                 540                 


Ala Leu Asp Ala Thr Ile Ala Trp Glu Ala Ser Pro Ala Gln Glu Ser 
545                 550                 555                 560 


Leu Glu Val Met Ala Gln Glu Ala Ser Leu Glu Ala Glu Leu Glu Ala 
                565                 570                 575     


Val Tyr Leu Thr Gln Gln Ala Gln Ser Thr Gly Ser Ala Pro Val Ala 
            580                 585                 590         


Pro Asp Glu Phe Ser Ser Arg Glu Glu Phe Val Val Ala Val Ser His 
        595                 600                 605             


Ser Ser Pro Ser Ala Leu Ala Leu Gln Ser Pro Leu Leu Pro Ala Trp 
    610                 615                 620                 


Arg Thr Leu Ser Val Ser Glu His Ala Pro Gly Leu Pro Gly Leu Pro 
625                 630                 635                 640 


Ser Thr Ala Ala Glu Val Glu Ala Gln Arg Glu His Gln Ala Ala Lys 
                645                 650                 655     


Arg Ala Cys Ser Ala Cys Ala Gly Thr Phe Gly Glu Asp Thr Ser Ala 
            660                 665                 670         


Leu Pro Ala Pro Gly Gly Gly Gly Ser Gly Gly Asp Pro Thr 
        675                 680                 685     


<210>  4
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Leu Val Asp Phe Phe Cys Glu Thr Cys Ser Lys Pro Trp Leu 
1               5                   10                  15      


Val Gly Trp Trp Asp Gln Phe Lys Arg Met Leu Asn Arg Glu Leu Thr 
            20                  25                  30          


His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Tyr Ile 
        35                  40                  45              


Ser Thr Thr Phe Leu Asp Lys Gln Asn Glu Val Glu Ile Pro Ser Pro 
    50                  55                  60                  


Thr Met Lys Glu Arg Glu Lys Gln Gln Ala Pro Arg Pro Arg Pro Ser 
65                  70                  75                  80  


Gln Pro Pro Pro Pro Pro Val Pro His Leu Gln Pro Met Ser Gln Ile 
                85                  90                  95      


Thr Gly Leu Lys Lys Leu Met His Ser Asn Ser Leu Asn Asn Ser Asn 
            100                 105                 110         


Ile Pro Arg Phe Gly Val Lys Thr Asp Gln Glu Glu Leu Leu Ala Gln 
        115                 120                 125             


Glu Leu Glu Asn Leu Asn Lys Trp Gly Leu Asn Ile Phe Cys Val Ser 
    130                 135                 140                 


Asp Tyr Ala Gly Gly Arg Ser Leu Thr Cys Ile Met Tyr Met Ile Phe 
145                 150                 155                 160 


Gln Glu Arg Asp Leu Leu Lys Lys Phe Arg Ile Pro Val Asp Thr Met 
                165                 170                 175     


Val Thr Tyr Met Leu Thr Leu Glu Asp His Tyr His Ala Asp Val Ala 
            180                 185                 190         


Tyr His Asn Ser Leu His Ala Ala Asp Val Leu Gln Ser Thr His Val 
        195                 200                 205             


Leu Leu Ala Thr Pro Ala Leu Asp Ala Val Phe Thr Asp Leu Glu Ile 
    210                 215                 220                 


Leu Ala Ala Leu Phe Ala Ala Ala Ile His Asp Val Asp His Pro Gly 
225                 230                 235                 240 


Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met 
                245                 250                 255     


Tyr Asn Asp Glu Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe 
            260                 265                 270         


Lys Leu Leu Gln Glu Asp Asn Cys Asp Ile Phe Gln Asn Leu Ser Lys 
        275                 280                 285             


Arg Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Met Val Leu Ala 
    290                 295                 300                 


Thr Asp Met Ser Lys His Met Thr Leu Leu Ala Asp Leu Lys Thr Met 
305                 310                 315                 320 


Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn 
                325                 330                 335     


Tyr Ser Asp Arg Ile Gln Val Leu Arg Asn Met Val His Cys Ala Asp 
            340                 345                 350         


Leu Ser Asn Pro Thr Lys Pro Leu Glu Leu Tyr Arg Gln Trp Thr Asp 
        355                 360                 365             


Arg Ile Met Ala Glu Phe Phe Gln Gln Gly Asp Arg Glu Arg Glu Arg 
    370                 375                 380                 


Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Thr Ala Ser Val Glu 
385                 390                 395                 400 


Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu 
                405                 410                 415     


Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Glu Ile Leu Asp Thr 
            420                 425                 430         


Leu Glu Asp Asn Arg Asp Trp Tyr Tyr Ser Ala Ile Arg Gln Ser Pro 
        435                 440                 445             


Ser Pro Pro Pro Glu Glu Glu Ser Arg Gly Pro Gly His Pro Pro Leu 
    450                 455                 460                 


Pro Asp Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu Glu Glu Glu Glu 
465                 470                 475                 480 


Glu Ile Ser Met Ala Gln Ile Pro Cys Thr Ala Gln Glu Ala Leu Thr 
                485                 490                 495     


Ala Gln Gly Leu Ser Gly Val Glu Glu Ala Leu Asp Ala Thr Ile Ala 
            500                 505                 510         


Trp Glu Ala Ser Pro Ala Gln Glu Ser Leu Glu Val Met Ala Gln Glu 
        515                 520                 525             


Ala Ser Leu Glu Ala Glu Leu Glu Ala Val Tyr Leu Thr Gln Gln Ala 
    530                 535                 540                 


Gln Ser Thr Gly Ser Ala Pro Val Ala Pro Asp Glu Phe Ser Ser Arg 
545                 550                 555                 560 


Glu Glu Phe Val Val Ala Val Ser His Ser Ser Pro Ser Ala Leu Ala 
                565                 570                 575     


Leu Gln Ser Pro Leu Leu Pro Ala Trp Arg Thr Leu Ser Val Ser Glu 
            580                 585                 590         


His Ala Pro Gly Leu Pro Gly Leu Pro Ser Thr Ala Ala Glu Val Glu 
        595                 600                 605             


Ala Gln Arg Glu His Gln Ala Ala Lys Arg Ala Cys Ser Ala Cys Ala 
    610                 615                 620                 


Gly Thr Phe Gly Glu Asp Thr Ser Ala Leu Pro Ala Pro Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Asp Pro Thr 
                645         


<210>  5
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Leu Pro Ser Asp Gln Gly Phe Lys Leu Leu Gly Asn Val Leu 
1               5                   10                  15      


Gln Gly Pro Glu Pro Tyr Arg Leu Leu Thr Ser Gly Leu Arg Leu His 
            20                  25                  30          


Gln Glu Leu Glu Asn Leu Asn Lys Trp Gly Leu Asn Ile Phe Cys Val 
        35                  40                  45              


Ser Asp Tyr Ala Gly Gly Arg Ser Leu Thr Cys Ile Met Tyr Met Ile 
    50                  55                  60                  


Phe Gln Glu Arg Asp Leu Leu Lys Lys Phe Arg Ile Pro Val Asp Thr 
65                  70                  75                  80  


Met Val Thr Tyr Met Leu Thr Leu Glu Asp His Tyr His Ala Asp Val 
                85                  90                  95      


Ala Tyr His Asn Ser Leu His Ala Ala Asp Val Leu Gln Ser Thr His 
            100                 105                 110         


Val Leu Leu Ala Thr Pro Ala Leu Asp Ala Val Phe Thr Asp Leu Glu 
        115                 120                 125             


Ile Leu Ala Ala Leu Phe Ala Ala Ala Ile His Asp Val Asp His Pro 
    130                 135                 140                 


Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu 
145                 150                 155                 160 


Met Tyr Asn Asp Glu Ser Val Leu Glu Asn His His Leu Ala Val Gly 
                165                 170                 175     


Phe Lys Leu Leu Gln Glu Asp Asn Cys Asp Ile Phe Gln Asn Leu Ser 
            180                 185                 190         


Lys Arg Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Met Val Leu 
        195                 200                 205             


Ala Thr Asp Met Ser Lys His Met Thr Leu Leu Ala Asp Leu Lys Thr 
    210                 215                 220                 


Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp 
225                 230                 235                 240 


Asn Tyr Ser Asp Arg Ile Gln Val Leu Arg Asn Met Val His Cys Ala 
                245                 250                 255     


Asp Leu Ser Asn Pro Thr Lys Pro Leu Glu Leu Tyr Arg Gln Trp Thr 
            260                 265                 270         


Asp Arg Ile Met Ala Glu Phe Phe Gln Gln Gly Asp Arg Glu Arg Glu 
        275                 280                 285             


Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Thr Ala Ser Val 
    290                 295                 300                 


Glu Lys Ser Gln Val Gln Ala Arg Gly Ile Asp Gly Arg Ala Gln Gly 
305                 310                 315                 320 


Gly Phe Tyr 
            


<210>  6
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Ser Gly Ala Ala Pro Arg Ala Arg Pro Arg Pro Pro Ala Leu 
1               5                   10                  15      


Ala Leu Pro Pro Thr Gly Pro Glu Ser Leu Thr His Phe Pro Phe Ser 
            20                  25                  30          


Asp Glu Asp Thr Arg Arg His Pro Pro Gly Arg Ser Val Ser Phe Glu 
        35                  40                  45              


Ala Glu Asn Gly Pro Thr Pro Ser Pro Gly Arg Ser Pro Leu Asp Ser 
    50                  55                  60                  


Gln Ala Ser Pro Gly Leu Val Leu His Ala Gly Ala Ala Thr Ser Gln 
65                  70                  75                  80  


Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Met Ser 
                85                  90                  95      


Pro Lys Thr Met Ser Arg Asn Ser Ser Val Thr Ser Glu Ala His Ala 
            100                 105                 110         


Glu Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg 
        115                 120                 125             


Ser Val Arg Ser Asn Phe Ser Leu Leu Thr Asn Val Pro Val Pro Ser 
    130                 135                 140                 


Asn Lys Arg Ser Pro Leu Gly Gly Pro Thr Pro Val Cys Lys Ala Thr 
145                 150                 155                 160 


Leu Ser Glu Glu Thr Cys Gln Gln Leu Ala Arg Glu Thr Leu Glu Glu 
                165                 170                 175     


Leu Asp Trp Cys Leu Glu Gln Leu Glu Thr Met Gln Thr Tyr Arg Ser 
            180                 185                 190         


Val Ser Glu Met Ala Ser His Lys Phe Lys Arg Met Leu Asn Arg Glu 
        195                 200                 205             


Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu 
    210                 215                 220                 


Tyr Ile Ser Thr Thr Phe Leu Asp Lys Gln Asn Glu Val Glu Ile Pro 
225                 230                 235                 240 


Ser Pro Thr Met Lys Glu Arg Glu Lys Gln Gln Ala Pro Arg Pro Arg 
                245                 250                 255     


Pro Ser Gln Pro Pro Pro Pro Pro Val Pro His Leu Gln Pro Met Ser 
            260                 265                 270         


Gln Ile Thr Gly Leu Lys Lys Leu Met His Ser Asn Ser Leu Asn Asn 
        275                 280                 285             


Ser Asn Ile Pro Arg Phe Gly Val Lys Thr Asp Gln Glu Glu Leu Leu 
    290                 295                 300                 


Ala Gln Glu Leu Glu Asn Leu Asn Lys Trp Gly Leu Asn Ile Phe Cys 
305                 310                 315                 320 


Val Ser Asp Tyr Ala Gly Gly Arg Ser Leu Thr Cys Ile Met Tyr Met 
                325                 330                 335     


Ile Phe Gln Glu Arg Asp Leu Leu Lys Lys Phe Arg Ile Pro Val Asp 
            340                 345                 350         


Thr Met Val Thr Tyr Met Leu Thr Leu Glu Asp His Tyr His Ala Asp 
        355                 360                 365             


Val Ala Tyr His Asn Ser Leu His Ala Ala Asp Val Leu Gln Ser Thr 
    370                 375                 380                 


His Val Leu Leu Ala Thr Pro Ala Leu Asp Ala Val Phe Thr Asp Leu 
385                 390                 395                 400 


Glu Ile Leu Ala Ala Leu Phe Ala Ala Ala Ile His Asp Val Asp His 
                405                 410                 415     


Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala 
            420                 425                 430         


Leu Met Tyr Asn Asp Glu Ser Val Leu Glu Asn His His Leu Ala Val 
        435                 440                 445             


Gly Phe Lys Leu Leu Gln Glu Asp Asn Cys Asp Ile Phe Gln Asn Leu 
    450                 455                 460                 


Ser Lys Arg Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Met Val 
465                 470                 475                 480 


Leu Ala Thr Asp Met Ser Lys His Met Thr Leu Leu Ala Asp Leu Lys 
                485                 490                 495     


Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu 
            500                 505                 510         


Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Arg Asn Met Val His Cys 
        515                 520                 525             


Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Glu Leu Tyr Arg Gln Trp 
    530                 535                 540                 


Thr Asp Arg Ile Met Ala Glu Phe Phe Gln Gln Gly Asp Arg Glu Arg 
545                 550                 555                 560 


Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Thr Ala Ser 
                565                 570                 575     


Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu 
            580                 585                 590         


Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Glu Ile Leu 
        595                 600                 605             


Asp Thr Leu Glu Asp Asn Arg Asp Trp Tyr Tyr Ser Ala Ile Arg Gln 
    610                 615                 620                 


Ser Pro Ser Pro Pro Pro Glu Glu Glu Ser Arg Gly Pro Gly His Pro 
625                 630                 635                 640 


Pro Leu Pro Asp Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu Glu Glu 
                645                 650                 655     


Glu Glu Glu Ile Ser Met Ala Gln Ile Pro Cys Thr Ala Gln Glu Ala 
            660                 665                 670         


Leu Thr Ala Gln Gly Leu Ser Gly Val Glu Glu Ala Leu Asp Ala Thr 
        675                 680                 685             


Ile Ala Trp Glu Ala Ser Pro Ala Gln Glu Ser Leu Glu Val Met Ala 
    690                 695                 700                 


Gln Glu Ala Ser Leu Glu Ala Glu Leu Glu Ala Val Tyr Leu Thr Gln 
705                 710                 715                 720 


Gln Ala Gln Ser Thr Gly Ser Ala Pro Val Ala Pro Asp Glu Phe Ser 
                725                 730                 735     


Ser Arg Glu Glu Phe Val Val Ala Val Ser His Ser Ser Pro Ser Ala 
            740                 745                 750         


Leu Ala Leu Gln Ser Pro Leu Leu Pro Ala Trp Arg Thr Leu Ser Val 
        755                 760                 765             


Ser Glu His Ala Pro Gly Leu Pro Gly Leu Pro Ser Thr Ala Ala Glu 
    770                 775                 780                 


Val Glu Ala Gln Arg Glu His Gln Ala Ala Lys Arg Ala Cys Ser Ala 
785                 790                 795                 800 


Cys Ala Gly Thr Phe Gly Glu Asp Thr Ser Ala Leu Pro Ala Pro Gly 
                805                 810                 815     


Gly Gly Gly Ser Gly Gly Asp Pro Thr 
            820                 825 


<210>  7
<211>  864
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Arg Ser Arg Ser Ala Leu Ser Val Ala Gly Thr Gly Asp Glu 
1               5                   10                  15      


Arg Ser Arg Glu Thr Pro Glu Ser Asp Arg Ala Asn Met Leu Gly Ala 
            20                  25                  30          


Asp Leu Arg Arg Pro Arg Arg Arg Leu Ser Ser Gly Pro Gly Leu Gly 
        35                  40                  45              


Trp Ala Gln Pro Glu Pro Ser Asp Pro Gly Val Pro Leu Pro Pro Arg 
    50                  55                  60                  


Pro Thr Thr Leu Pro Leu Leu Ile Pro Pro Arg Ile Ser Ile Thr Arg 
65                  70                  75                  80  


Ala Glu Asn Asp Ser Phe Glu Ala Glu Asn Gly Pro Thr Pro Ser Pro 
                85                  90                  95      


Gly Arg Ser Pro Leu Asp Ser Gln Ala Ser Pro Gly Leu Val Leu His 
            100                 105                 110         


Ala Gly Ala Ala Thr Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser 
        115                 120                 125             


Asp Ser Asp Tyr Asp Met Ser Pro Lys Thr Met Ser Arg Asn Ser Ser 
    130                 135                 140                 


Val Thr Ser Glu Ala His Ala Glu Asp Leu Ile Val Thr Pro Phe Ala 
145                 150                 155                 160 


Gln Val Leu Ala Ser Leu Arg Ser Val Arg Ser Asn Phe Ser Leu Leu 
                165                 170                 175     


Thr Asn Val Pro Val Pro Ser Asn Lys Arg Ser Pro Leu Gly Gly Pro 
            180                 185                 190         


Thr Pro Val Cys Lys Ala Thr Leu Ser Glu Glu Thr Cys Gln Gln Leu 
        195                 200                 205             


Ala Arg Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu Glu Gln Leu Glu 
    210                 215                 220                 


Thr Met Gln Thr Tyr Arg Ser Val Ser Glu Met Ala Ser His Lys Phe 
225                 230                 235                 240 


Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser Arg 
                245                 250                 255     


Ser Gly Asn Gln Val Ser Glu Tyr Ile Ser Thr Thr Phe Leu Asp Lys 
            260                 265                 270         


Gln Asn Glu Val Glu Ile Pro Ser Pro Thr Met Lys Glu Arg Glu Lys 
        275                 280                 285             


Gln Gln Ala Pro Arg Pro Arg Pro Ser Gln Pro Pro Pro Pro Pro Val 
    290                 295                 300                 


Pro His Leu Gln Pro Met Ser Gln Ile Thr Gly Leu Lys Lys Leu Met 
305                 310                 315                 320 


His Ser Asn Ser Leu Asn Asn Ser Asn Ile Pro Arg Phe Gly Val Lys 
                325                 330                 335     


Thr Asp Gln Glu Glu Leu Leu Ala Gln Glu Leu Glu Asn Leu Asn Lys 
            340                 345                 350         


Trp Gly Leu Asn Ile Phe Cys Val Ser Asp Tyr Ala Gly Gly Arg Ser 
        355                 360                 365             


Leu Thr Cys Ile Met Tyr Met Ile Phe Gln Glu Arg Asp Leu Leu Lys 
    370                 375                 380                 


Lys Phe Arg Ile Pro Val Asp Thr Met Val Thr Tyr Met Leu Thr Leu 
385                 390                 395                 400 


Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Ser Leu His Ala 
                405                 410                 415     


Ala Asp Val Leu Gln Ser Thr His Val Leu Leu Ala Thr Pro Ala Leu 
            420                 425                 430         


Asp Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Leu Phe Ala Ala 
        435                 440                 445             


Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile 
    450                 455                 460                 


Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Glu Ser Val Leu 
465                 470                 475                 480 


Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Asp Asn 
                485                 490                 495     


Cys Asp Ile Phe Gln Asn Leu Ser Lys Arg Gln Arg Gln Ser Leu Arg 
            500                 505                 510         


Lys Met Val Ile Asp Met Val Leu Ala Thr Asp Met Ser Lys His Met 
        515                 520                 525             


Thr Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr 
    530                 535                 540                 


Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val 
545                 550                 555                 560 


Leu Arg Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro 
                565                 570                 575     


Leu Glu Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Ala Glu Phe Phe 
            580                 585                 590         


Gln Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met 
        595                 600                 605             


Cys Asp Lys His Thr Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile 
    610                 615                 620                 


Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His 
625                 630                 635                 640 


Pro Asp Ala Gln Glu Ile Leu Asp Thr Leu Glu Asp Asn Arg Asp Trp 
                645                 650                 655     


Tyr Tyr Ser Ala Ile Arg Gln Ser Pro Ser Pro Pro Pro Glu Glu Glu 
            660                 665                 670         


Ser Arg Gly Pro Gly His Pro Pro Leu Pro Asp Lys Phe Gln Phe Glu 
        675                 680                 685             


Leu Thr Leu Glu Glu Glu Glu Glu Glu Glu Ile Ser Met Ala Gln Ile 
    690                 695                 700                 


Pro Cys Thr Ala Gln Glu Ala Leu Thr Ala Gln Gly Leu Ser Gly Val 
705                 710                 715                 720 


Glu Glu Ala Leu Asp Ala Thr Ile Ala Trp Glu Ala Ser Pro Ala Gln 
                725                 730                 735     


Glu Ser Leu Glu Val Met Ala Gln Glu Ala Ser Leu Glu Ala Glu Leu 
            740                 745                 750         


Glu Ala Val Tyr Leu Thr Gln Gln Ala Gln Ser Thr Gly Ser Ala Pro 
        755                 760                 765             


Val Ala Pro Asp Glu Phe Ser Ser Arg Glu Glu Phe Val Val Ala Val 
    770                 775                 780                 


Ser His Ser Ser Pro Ser Ala Leu Ala Leu Gln Ser Pro Leu Leu Pro 
785                 790                 795                 800 


Ala Trp Arg Thr Leu Ser Val Ser Glu His Ala Pro Gly Leu Pro Gly 
                805                 810                 815     


Leu Pro Ser Thr Ala Ala Glu Val Glu Ala Gln Arg Glu His Gln Ala 
            820                 825                 830         


Ala Lys Arg Ala Cys Ser Ala Cys Ala Gly Thr Phe Gly Glu Asp Thr 
        835                 840                 845             


Ser Ala Leu Pro Ala Pro Gly Gly Gly Gly Ser Gly Gly Asp Pro Thr 
    850                 855                 860                 


<210>  8
<211>  736
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Lys Lys Ser Arg Ser Val Met Thr Val Met Ala Asp Asp Asn Val 
1               5                   10                  15      


Lys Asp Tyr Phe Glu Cys Ser Leu Ser Lys Ser Tyr Ser Ser Ser Ser 
            20                  25                  30          


Asn Thr Leu Gly Ile Asp Leu Trp Arg Gly Arg Arg Cys Cys Ser Gly 
        35                  40                  45              


Asn Leu Gln Leu Pro Pro Leu Ser Gln Arg Gln Ser Glu Arg Ala Arg 
    50                  55                  60                  


Thr Pro Glu Gly Asp Gly Ile Ser Arg Pro Thr Thr Leu Pro Leu Thr 
65                  70                  75                  80  


Thr Leu Pro Ser Ile Ala Ile Thr Thr Val Ser Gln Glu Cys Phe Asp 
                85                  90                  95      


Val Glu Asn Gly Pro Ser Pro Gly Arg Ser Pro Leu Asp Pro Gln Ala 
            100                 105                 110         


Ser Ser Ser Ala Gly Leu Val Leu His Ala Thr Phe Pro Gly His Ser 
        115                 120                 125             


Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Leu 
    130                 135                 140                 


Ser Pro Lys Ala Met Ser Arg Asn Ser Ser Leu Pro Ser Glu Gln His 
145                 150                 155                 160 


Gly Asp Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu 
                165                 170                 175     


Arg Ser Val Arg Asn Asn Phe Thr Ile Leu Thr Asn Leu His Gly Thr 
            180                 185                 190         


Ser Asn Lys Arg Ser Pro Ala Ala Ser Gln Pro Pro Val Ser Arg Val 
        195                 200                 205             


Asn Pro Gln Glu Glu Ser Tyr Gln Lys Leu Ala Met Glu Thr Leu Glu 
    210                 215                 220                 


Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Ile Gln Thr Tyr Arg 
225                 230                 235                 240 


Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg 
                245                 250                 255     


Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser 
            260                 265                 270         


Glu Tyr Ile Ser Asn Thr Phe Leu Asp Lys Gln Asn Asp Val Glu Ile 
        275                 280                 285             


Pro Ser Pro Thr Gln Lys Asp Arg Glu Lys Lys Lys Lys Gln Gln Leu 
    290                 295                 300                 


Met Thr Gln Ile Ser Gly Val Lys Lys Leu Met His Ser Ser Ser Leu 
305                 310                 315                 320 


Asn Asn Thr Ser Ile Ser Arg Phe Gly Val Asn Thr Glu Asn Glu Asp 
                325                 330                 335     


His Leu Ala Lys Glu Leu Glu Asp Leu Asn Lys Trp Gly Leu Asn Ile 
            340                 345                 350         


Phe Asn Val Ala Gly Tyr Ser His Asn Arg Pro Leu Thr Cys Ile Met 
        355                 360                 365             


Tyr Ala Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Arg Ile Ser 
    370                 375                 380                 


Ser Asp Thr Phe Ile Thr Tyr Met Met Thr Leu Glu Asp His Tyr His 
385                 390                 395                 400 


Ser Asp Val Ala Tyr His Asn Ser Leu His Ala Ala Asp Val Ala Gln 
                405                 410                 415     


Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu Asp Ala Val Phe Thr 
            420                 425                 430         


Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ala Ala Ile His Asp Val 
        435                 440                 445             


Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu 
    450                 455                 460                 


Leu Ala Leu Met Tyr Asn Asp Glu Ser Val Leu Glu Asn His His Leu 
465                 470                 475                 480 


Ala Val Gly Phe Lys Leu Leu Gln Glu Glu His Cys Asp Ile Phe Met 
                485                 490                 495     


Asn Leu Thr Lys Lys Gln Arg Gln Thr Leu Arg Lys Met Val Ile Asp 
            500                 505                 510         


Met Val Leu Ala Thr Asp Met Ser Lys His Met Ser Leu Leu Ala Asp 
        515                 520                 525             


Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu 
    530                 535                 540                 


Leu Leu Asp Asn Tyr Thr Asp Arg Ile Gln Val Leu Arg Asn Met Val 
545                 550                 555                 560 


His Cys Ala Asp Leu Ser Asn Pro Thr Lys Ser Leu Glu Leu Tyr Arg 
                565                 570                 575     


Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe Gln Gln Gly Asp Lys 
            580                 585                 590         


Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Thr 
        595                 600                 605             


Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His 
    610                 615                 620                 


Pro Leu Trp Glu Thr Trp Ala Asp Leu Val Gln Pro Asp Ala Gln Asp 
625                 630                 635                 640 


Ile Leu Asp Thr Leu Glu Asp Asn Arg Asn Trp Tyr Gln Ser Met Ile 
                645                 650                 655     


Pro Gln Ser Pro Ser Pro Pro Leu Asp Glu Gln Asn Arg Asp Cys Gln 
            660                 665                 670         


Gly Leu Met Glu Lys Phe Gln Phe Glu Leu Thr Leu Asp Glu Glu Asp 
        675                 680                 685             


Ser Glu Gly Pro Glu Lys Glu Gly Glu Gly His Ser Tyr Phe Ser Ser 
    690                 695                 700                 


Thr Lys Thr Leu Cys Val Ile Asp Pro Glu Asn Arg Asp Ser Leu Gly 
705                 710                 715                 720 


Glu Thr Asp Ile Asp Ile Ala Thr Glu Asp Lys Ser Pro Val Asp Thr 
                725                 730                 735     


<210>  9
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Glu His Gly Gly Thr Phe Ser Ser Thr Gly Ile Ser Gly Gly 
1               5                   10                  15      


Ser Gly Asp Ser Ala Met Asp Ser Leu Gln Pro Leu Gln Pro Asn Tyr 
            20                  25                  30          


Met Pro Val Cys Leu Phe Ala Glu Glu Ser Tyr Gln Lys Leu Ala Met 
        35                  40                  45              


Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Ile 
    50                  55                  60                  


Gln Thr Tyr Arg Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg 
65                  70                  75                  80  


Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly 
                85                  90                  95      


Asn Gln Val Ser Glu Tyr Ile Ser Asn Thr Phe Leu Asp Lys Gln Asn 
            100                 105                 110         


Asp Val Glu Ile Pro Ser Pro Thr Gln Lys Asp Arg Glu Lys Lys Lys 
        115                 120                 125             


Lys Gln Gln Leu Met Thr Gln Ile Ser Gly Val Lys Lys Leu Met His 
    130                 135                 140                 


Ser Ser Ser Leu Asn Asn Thr Ser Ile Ser Arg Phe Gly Val Asn Thr 
145                 150                 155                 160 


Glu Asn Glu Asp His Leu Ala Lys Glu Leu Glu Asp Leu Asn Lys Trp 
                165                 170                 175     


Gly Leu Asn Ile Phe Asn Val Ala Gly Tyr Ser His Asn Arg Pro Leu 
            180                 185                 190         


Thr Cys Ile Met Tyr Ala Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr 
        195                 200                 205             


Phe Arg Ile Ser Ser Asp Thr Phe Ile Thr Tyr Met Met Thr Leu Glu 
    210                 215                 220                 


Asp His Tyr His Ser Asp Val Ala Tyr His Asn Ser Leu His Ala Ala 
225                 230                 235                 240 


Asp Val Ala Gln Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu Asp 
                245                 250                 255     


Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ala Ala 
            260                 265                 270         


Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn 
        275                 280                 285             


Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Glu Ser Val Leu Glu 
    290                 295                 300                 


Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Glu His Cys 
305                 310                 315                 320 


Asp Ile Phe Met Asn Leu Thr Lys Lys Gln Arg Gln Thr Leu Arg Lys 
                325                 330                 335     


Met Val Ile Asp Met Val Leu Ala Thr Asp Met Ser Lys His Met Ser 
            340                 345                 350         


Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser 
        355                 360                 365             


Ser Gly Val Leu Leu Leu Asp Asn Tyr Thr Asp Arg Ile Gln Val Leu 
    370                 375                 380                 


Arg Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Ser Leu 
385                 390                 395                 400 


Glu Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe Gln 
                405                 410                 415     


Gln Gly Asp Lys Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met Cys 
            420                 425                 430         


Asp Lys His Thr Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp 
        435                 440                 445             


Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val Gln Pro 
    450                 455                 460                 


Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg Asn Trp Tyr 
465                 470                 475                 480 


Gln Ser Met Ile Pro Gln Ser Pro Ser Pro Pro Leu Asp Glu Gln Asn 
                485                 490                 495     


Arg Asp Cys Gln Gly Leu Met Glu Lys Phe Gln Phe Glu Leu Thr Leu 
            500                 505                 510         


Asp Glu Glu Asp Ser Glu Gly Pro Glu Lys Glu Gly Glu Gly His Ser 
        515                 520                 525             


Tyr Phe Ser Ser Thr Lys Thr Leu Cys Val Ile Asp Pro Glu Asn Arg 
    530                 535                 540                 


Asp Ser Leu Gly Glu Thr Asp Ile Asp Ile Ala Thr Glu Asp Lys Ser 
545                 550                 555                 560 


Pro Val Asp Thr 
                


<210>  10
<211>  721
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Thr Ala Lys Asp Ser Ser Lys Glu Leu Thr Ala Ser Glu Pro Glu 
1               5                   10                  15      


Val Cys Ile Lys Thr Phe Lys Glu Gln Met His Leu Glu Leu Glu Leu 
            20                  25                  30          


Pro Arg Leu Pro Gly Asn Arg Pro Thr Ser Pro Lys Ile Ser Pro Arg 
        35                  40                  45              


Ser Ser Pro Arg Asn Ser Pro Cys Phe Phe Arg Lys Leu Leu Val Asn 
    50                  55                  60                  


Lys Ser Ile Arg Gln Arg Arg Arg Phe Thr Val Ala His Thr Cys Phe 
65                  70                  75                  80  


Asp Val Glu Asn Gly Pro Ser Pro Gly Arg Ser Pro Leu Asp Pro Gln 
                85                  90                  95      


Ala Ser Ser Ser Ala Gly Leu Val Leu His Ala Thr Phe Pro Gly His 
            100                 105                 110         


Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp 
        115                 120                 125             


Leu Ser Pro Lys Ala Met Ser Arg Asn Ser Ser Leu Pro Ser Glu Gln 
    130                 135                 140                 


His Gly Asp Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser 
145                 150                 155                 160 


Leu Arg Ser Val Arg Asn Asn Phe Thr Ile Leu Thr Asn Leu His Gly 
                165                 170                 175     


Thr Ser Asn Lys Arg Ser Pro Ala Ala Ser Gln Pro Pro Val Ser Arg 
            180                 185                 190         


Val Asn Pro Gln Glu Glu Ser Tyr Gln Lys Leu Ala Met Glu Thr Leu 
        195                 200                 205             


Glu Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Ile Gln Thr Tyr 
    210                 215                 220                 


Arg Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn 
225                 230                 235                 240 


Arg Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val 
                245                 250                 255     


Ser Glu Tyr Ile Ser Asn Thr Phe Leu Asp Lys Gln Asn Asp Val Glu 
            260                 265                 270         


Ile Pro Ser Pro Thr Gln Lys Asp Arg Glu Lys Lys Lys Lys Gln Gln 
        275                 280                 285             


Leu Met Thr Gln Ile Ser Gly Val Lys Lys Leu Met His Ser Ser Ser 
    290                 295                 300                 


Leu Asn Asn Thr Ser Ile Ser Arg Phe Gly Val Asn Thr Glu Asn Glu 
305                 310                 315                 320 


Asp His Leu Ala Lys Glu Leu Glu Asp Leu Asn Lys Trp Gly Leu Asn 
                325                 330                 335     


Ile Phe Asn Val Ala Gly Tyr Ser His Asn Arg Pro Leu Thr Cys Ile 
            340                 345                 350         


Met Tyr Ala Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Arg Ile 
        355                 360                 365             


Ser Ser Asp Thr Phe Ile Thr Tyr Met Met Thr Leu Glu Asp His Tyr 
    370                 375                 380                 


His Ser Asp Val Ala Tyr His Asn Ser Leu His Ala Ala Asp Val Ala 
385                 390                 395                 400 


Gln Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu Asp Ala Val Phe 
                405                 410                 415     


Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ala Ala Ile His Asp 
            420                 425                 430         


Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser 
        435                 440                 445             


Glu Leu Ala Leu Met Tyr Asn Asp Glu Ser Val Leu Glu Asn His His 
    450                 455                 460                 


Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Glu His Cys Asp Ile Phe 
465                 470                 475                 480 


Met Asn Leu Thr Lys Lys Gln Arg Gln Thr Leu Arg Lys Met Val Ile 
                485                 490                 495     


Asp Met Val Leu Ala Thr Asp Met Ser Lys His Met Ser Leu Leu Ala 
            500                 505                 510         


Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val 
        515                 520                 525             


Leu Leu Leu Asp Asn Tyr Thr Asp Arg Ile Gln Val Leu Arg Asn Met 
    530                 535                 540                 


Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Ser Leu Glu Leu Tyr 
545                 550                 555                 560 


Arg Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe Gln Gln Gly Asp 
                565                 570                 575     


Lys Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His 
            580                 585                 590         


Thr Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val 
        595                 600                 605             


His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val Gln Pro Asp Ala Gln 
    610                 615                 620                 


Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg Asn Trp Tyr Gln Ser Met 
625                 630                 635                 640 


Ile Pro Gln Ser Pro Ser Pro Pro Leu Asp Glu Gln Asn Arg Asp Cys 
                645                 650                 655     


Gln Gly Leu Met Glu Lys Phe Gln Phe Glu Leu Thr Leu Asp Glu Glu 
            660                 665                 670         


Asp Ser Glu Gly Pro Glu Lys Glu Gly Glu Gly His Ser Tyr Phe Ser 
        675                 680                 685             


Ser Thr Lys Thr Leu Cys Val Ile Asp Pro Glu Asn Arg Asp Ser Leu 
    690                 695                 700                 


Gly Glu Thr Asp Ile Asp Ile Ala Thr Glu Asp Lys Ser Pro Val Asp 
705                 710                 715                 720 


Thr 
    


<210>  11
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Glu Ala Asn Tyr Leu Leu Ser Val Ser Trp Gly Tyr Ile Lys 
1               5                   10                  15      


Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser 
            20                  25                  30          


Arg Ser Gly Asn Gln Val Ser Glu Tyr Ile Ser Asn Thr Phe Leu Asp 
        35                  40                  45              


Lys Gln Asn Asp Val Glu Ile Pro Ser Pro Thr Gln Lys Asp Arg Glu 
    50                  55                  60                  


Lys Lys Lys Lys Gln Gln Leu Met Thr Gln Ile Ser Gly Val Lys Lys 
65                  70                  75                  80  


Leu Met His Ser Ser Ser Leu Asn Asn Thr Ser Ile Ser Arg Phe Gly 
                85                  90                  95      


Val Asn Thr Glu Asn Glu Asp His Leu Ala Lys Glu Leu Glu Asp Leu 
            100                 105                 110         


Asn Lys Trp Gly Leu Asn Ile Phe Asn Val Ala Gly Tyr Ser His Asn 
        115                 120                 125             


Arg Pro Leu Thr Cys Ile Met Tyr Ala Ile Phe Gln Glu Arg Asp Leu 
    130                 135                 140                 


Leu Lys Thr Phe Arg Ile Ser Ser Asp Thr Phe Ile Thr Tyr Met Met 
145                 150                 155                 160 


Thr Leu Glu Asp His Tyr His Ser Asp Val Ala Tyr His Asn Ser Leu 
                165                 170                 175     


His Ala Ala Asp Val Ala Gln Ser Thr His Val Leu Leu Ser Thr Pro 
            180                 185                 190         


Ala Leu Asp Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe 
        195                 200                 205             


Ala Ala Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe 
    210                 215                 220                 


Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Glu Ser 
225                 230                 235                 240 


Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu 
                245                 250                 255     


Glu His Cys Asp Ile Phe Met Asn Leu Thr Lys Lys Gln Arg Gln Thr 
            260                 265                 270         


Leu Arg Lys Met Val Ile Asp Met Val Leu Ala Thr Asp Met Ser Lys 
        275                 280                 285             


His Met Ser Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys 
    290                 295                 300                 


Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Thr Asp Arg Ile 
305                 310                 315                 320 


Gln Val Leu Arg Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr 
                325                 330                 335     


Lys Ser Leu Glu Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu 
            340                 345                 350         


Phe Phe Gln Gln Gly Asp Lys Glu Arg Glu Arg Gly Met Glu Ile Ser 
        355                 360                 365             


Pro Met Cys Asp Lys His Thr Ala Ser Val Glu Lys Ser Gln Val Gly 
    370                 375                 380                 


Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu 
385                 390                 395                 400 


Val Gln Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg 
                405                 410                 415     


Asn Trp Tyr Gln Ser Met Ile Pro Gln Ser Pro Ser Pro Pro Leu Asp 
            420                 425                 430         


Glu Gln Asn Arg Asp Cys Gln Gly Leu Met Glu Lys Phe Gln Phe Glu 
        435                 440                 445             


Leu Thr Leu Asp Glu Glu Asp Ser Glu Gly Pro Glu Lys Glu Gly Glu 
    450                 455                 460                 


Gly His Ser Tyr Phe Ser Ser Thr Lys Thr Leu Cys Val Ile Asp Pro 
465                 470                 475                 480 


Glu Asn Arg Asp Ser Leu Gly Glu Thr Asp Ile Asp Ile Ala Thr Glu 
                485                 490                 495     


Asp Lys Ser Pro Val Asp Thr 
            500             


<210>  12
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Asn Leu Gly Val Gly Glu Gly Ala Glu Ala Cys Ser Arg Leu 
1               5                   10                  15      


Ser Arg Ser Arg Gly Arg His Ser Met Thr Arg Ala Pro Lys His Leu 
            20                  25                  30          


Trp Arg Gln Pro Arg Arg Pro Ile Arg Ile Gln Gln Arg Phe Tyr Ser 
        35                  40                  45              


Asp Pro Asp Lys Ser Ala Gly Cys Arg Glu Arg Asp Leu Ser Pro Arg 
    50                  55                  60                  


Pro Glu Leu Arg Lys Ser Arg Leu Ser Trp Pro Val Ser Ser Cys Arg 
65                  70                  75                  80  


Arg Phe Asp Leu Glu Asn Gly Leu Ser Cys Gly Arg Arg Ala Leu Asp 
                85                  90                  95      


Pro Gln Ser Ser Pro Gly Leu Gly Arg Ile Met Gln Ala Pro Val Pro 
            100                 105                 110         


His Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr 
        115                 120                 125             


Glu Leu Ser Pro Lys Ala Met Ser Arg Asn Ser Ser Val Ala Ser Asp 
    130                 135                 140                 


Leu His Gly Glu Asp Met Ile Val Thr Pro Phe Ala Gln Val Leu Ala 
145                 150                 155                 160 


Ser Leu Arg Thr Val Arg Ser Asn Val Ala Ala Leu Ala Arg Gln Gln 
                165                 170                 175     


Cys Leu Gly Ala Ala Lys Gln Gly Pro Val Gly Asn Pro Ser Ser Ser 
            180                 185                 190         


Asn Gln Leu Pro Pro Ala Glu Asp Thr Gly Gln Lys Leu Ala Leu Glu 
        195                 200                 205             


Thr Leu Asp Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln 
    210                 215                 220                 


Thr Arg His Ser Val Gly Glu Met Ala Ser Asn Lys Phe Lys Arg Ile 
225                 230                 235                 240 


Leu Asn Arg Glu Leu Thr His Leu Ser Glu Thr Ser Arg Ser Gly Asn 
                245                 250                 255     


Gln Val Ser Glu Tyr Ile Ser Arg Thr Phe Leu Asp Gln Gln Thr Glu 
            260                 265                 270         


Val Glu Leu Pro Lys Val Thr Ala Glu Glu Ala Pro Gln Pro Met Ser 
        275                 280                 285             


Arg Ile Ser Gly Leu His Gly Leu Cys His Ser Ala Ser Leu Ser Ser 
    290                 295                 300                 


Ala Thr Val Pro Arg Phe Gly Val Gln Thr Asp Gln Glu Glu Gln Leu 
305                 310                 315                 320 


Ala Lys Glu Leu Glu Asp Thr Asn Lys Trp Gly Leu Asp Val Phe Lys 
                325                 330                 335     


Val Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Ala Ile Ile Phe Ser 
            340                 345                 350         


Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Gln Ile Pro Ala Asp 
        355                 360                 365             


Thr Leu Ala Thr Tyr Leu Leu Met Leu Glu Gly His Tyr His Ala Asn 
    370                 375                 380                 


Val Ala Tyr His Asn Ser Leu His Ala Ala Asp Val Ala Gln Ser Thr 
385                 390                 395                 400 


His Val Leu Leu Ala Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu 
                405                 410                 415     


Glu Ile Leu Ala Ala Leu Phe Ala Ser Ala Ile His Asp Val Asp His 
            420                 425                 430         


Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala 
        435                 440                 445             


Leu Met Tyr Asn Asp Ala Ser Val Leu Glu Asn His His Leu Ala Val 
    450                 455                 460                 


Gly Phe Lys Leu Leu Gln Ala Glu Asn Cys Asp Ile Phe Gln Asn Leu 
465                 470                 475                 480 


Ser Ala Lys Gln Arg Leu Ser Leu Arg Arg Met Val Ile Asp Met Val 
                485                 490                 495     


Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys 
            500                 505                 510         


Thr Met Val Glu Thr Lys Lys Val Thr Ser Leu Gly Val Leu Leu Leu 
        515                 520                 525             


Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Leu Val His Cys 
    530                 535                 540                 


Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Pro Leu Tyr Arg Gln Trp 
545                 550                 555                 560 


Thr Asp Arg Ile Met Ala Glu Phe Phe Gln Gln Gly Asp Arg Glu Arg 
                565                 570                 575     


Glu Ser Gly Leu Asp Ile Ser Pro Met Cys Asp Lys His Thr Ala Ser 
            580                 585                 590         


Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Ala His Pro Leu 
        595                 600                 605             


Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Leu Leu 
    610                 615                 620                 


Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Lys Ile Pro Arg 
625                 630                 635                 640 


Ser Pro Ser Asp Leu Thr Asn Pro Glu Arg Asp Gly Pro Asp Arg Phe 
                645                 650                 655     


Gln Phe Glu Leu Thr Leu Glu Glu Ala Glu Glu Glu Asp Glu Glu Glu 
            660                 665                 670         


Glu Glu Glu Gly Glu Glu Thr Ala Leu Ala Lys Glu Ala Leu Glu Leu 
        675                 680                 685             


Pro Asp Thr Glu Leu Leu Ser Pro Glu Ala Gly Pro Asp Pro Gly Asp 
    690                 695                 700                 


Leu Pro Leu Asp Asn Gln Arg Thr 
705                 710         


<210>  13
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gln Ala Pro Val Pro His Ser Gln Arg Arg Glu Ser Phe Leu Tyr 
1               5                   10                  15      


Arg Ser Asp Ser Asp Tyr Glu Leu Ser Pro Lys Ala Met Ser Arg Asn 
            20                  25                  30          


Ser Ser Val Ala Ser Asp Leu His Gly Glu Asp Met Ile Val Thr Pro 
        35                  40                  45              


Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Ser Asn Val Ala 
    50                  55                  60                  


Ala Leu Ala Arg Gln Gln Cys Leu Gly Ala Ala Lys Gln Gly Pro Val 
65                  70                  75                  80  


Gly Asn Pro Ser Ser Ser Asn Gln Leu Pro Pro Ala Glu Asp Thr Gly 
                85                  90                  95      


Gln Lys Leu Ala Leu Glu Thr Leu Asp Glu Leu Asp Trp Cys Leu Asp 
            100                 105                 110         


Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Gly Glu Met Ala Ser 
        115                 120                 125             


Asn Lys Phe Lys Arg Ile Leu Asn Arg Glu Leu Thr His Leu Ser Glu 
    130                 135                 140                 


Thr Ser Arg Ser Gly Asn Gln Val Ser Glu Tyr Ile Ser Arg Thr Phe 
145                 150                 155                 160 


Leu Asp Gln Gln Thr Glu Val Glu Leu Pro Lys Val Thr Ala Glu Glu 
                165                 170                 175     


Ala Pro Gln Pro Met Ser Arg Ile Ser Gly Leu His Gly Leu Cys His 
            180                 185                 190         


Ser Ala Ser Leu Ser Ser Ala Thr Val Pro Arg Phe Gly Val Gln Thr 
        195                 200                 205             


Asp Gln Glu Glu Gln Leu Ala Lys Glu Leu Glu Asp Thr Asn Lys Trp 
    210                 215                 220                 


Gly Leu Asp Val Phe Lys Val Ala Glu Leu Ser Gly Asn Arg Pro Leu 
225                 230                 235                 240 


Thr Ala Ile Ile Phe Ser Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr 
                245                 250                 255     


Phe Gln Ile Pro Ala Asp Thr Leu Ala Thr Tyr Leu Leu Met Leu Glu 
            260                 265                 270         


Gly His Tyr His Ala Asn Val Ala Tyr His Asn Ser Leu His Ala Ala 
        275                 280                 285             


Asp Val Ala Gln Ser Thr His Val Leu Leu Ala Thr Pro Ala Leu Glu 
    290                 295                 300                 


Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Leu Phe Ala Ser Ala 
305                 310                 315                 320 


Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn 
                325                 330                 335     


Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ala Ser Val Leu Glu 
            340                 345                 350         


Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Ala Glu Asn Cys 
        355                 360                 365             


Asp Ile Phe Gln Asn Leu Ser Ala Lys Gln Arg Leu Ser Leu Arg Arg 
    370                 375                 380                 


Met Val Ile Asp Met Val Leu Ala Thr Asp Met Ser Lys His Met Asn 
385                 390                 395                 400 


Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser 
                405                 410                 415     


Leu Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu 
            420                 425                 430         


Gln Asn Leu Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu 
        435                 440                 445             


Pro Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Ala Glu Phe Phe Gln 
    450                 455                 460                 


Gln Gly Asp Arg Glu Arg Glu Ser Gly Leu Asp Ile Ser Pro Met Cys 
465                 470                 475                 480 


Asp Lys His Thr Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp 
                485                 490                 495     


Tyr Ile Ala His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His Pro 
            500                 505                 510         


Asp Ala Gln Asp Leu Leu Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr 
        515                 520                 525             


Gln Ser Lys Ile Pro Arg Ser Pro Ser Asp Leu Thr Asn Pro Glu Arg 
    530                 535                 540                 


Asp Gly Pro Asp Arg Phe Gln Phe Glu Leu Thr Leu Glu Glu Ala Glu 
545                 550                 555                 560 


Glu Glu Asp Glu Glu Glu Glu Glu Glu Gly Glu Glu Thr Ala Leu Ala 
                565                 570                 575     


Lys Glu Ala Leu Glu Leu Pro Asp Thr Glu Leu Leu Ser Pro Glu Ala 
            580                 585                 590         


Gly Pro Asp Pro Gly Asp Leu Pro Leu Asp Asn Gln Arg Thr 
        595                 600                 605     


<210>  14
<211>  680
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gln Gly Pro Pro Ala Pro Ala Pro Val Pro Gly Pro Gly Ser Pro 
1               5                   10                  15      


Arg Gly Ser Pro Arg Gly Ser Pro Gly Leu Phe Arg Lys Leu Leu Val 
            20                  25                  30          


Asn Gln Ser Ile Arg Leu Gln Arg Arg Phe Thr Val Ala His Pro Leu 
        35                  40                  45              


Cys Phe Asp Leu Glu Asn Gly Leu Ser Cys Gly Arg Arg Ala Leu Asp 
    50                  55                  60                  


Pro Gln Ser Ser Pro Gly Leu Gly Arg Ile Met Gln Ala Pro Val Pro 
65                  70                  75                  80  


His Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr 
                85                  90                  95      


Glu Leu Ser Pro Lys Ala Met Ser Arg Asn Ser Ser Val Ala Ser Asp 
            100                 105                 110         


Leu His Gly Glu Asp Met Ile Val Thr Pro Phe Ala Gln Val Leu Ala 
        115                 120                 125             


Ser Leu Arg Thr Val Arg Ser Asn Val Ala Ala Leu Ala Arg Gln Gln 
    130                 135                 140                 


Cys Leu Gly Ala Ala Lys Gln Gly Pro Val Gly Asn Pro Ser Ser Ser 
145                 150                 155                 160 


Asn Gln Leu Pro Pro Ala Glu Asp Thr Gly Gln Lys Leu Ala Leu Glu 
                165                 170                 175     


Thr Leu Asp Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln 
            180                 185                 190         


Thr Arg His Ser Val Gly Glu Met Ala Ser Asn Lys Phe Lys Arg Ile 
        195                 200                 205             


Leu Asn Arg Glu Leu Thr His Leu Ser Glu Thr Ser Arg Ser Gly Asn 
    210                 215                 220                 


Gln Val Ser Glu Tyr Ile Ser Arg Thr Phe Leu Asp Gln Gln Thr Glu 
225                 230                 235                 240 


Val Glu Leu Pro Lys Val Thr Ala Glu Glu Ala Pro Gln Pro Met Ser 
                245                 250                 255     


Arg Ile Ser Gly Leu His Gly Leu Cys His Ser Ala Ser Leu Ser Ser 
            260                 265                 270         


Ala Thr Val Pro Arg Phe Gly Val Gln Thr Asp Gln Glu Glu Gln Leu 
        275                 280                 285             


Ala Lys Glu Leu Glu Asp Thr Asn Lys Trp Gly Leu Asp Val Phe Lys 
    290                 295                 300                 


Val Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Ala Ile Ile Phe Ser 
305                 310                 315                 320 


Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Gln Ile Pro Ala Asp 
                325                 330                 335     


Thr Leu Ala Thr Tyr Leu Leu Met Leu Glu Gly His Tyr His Ala Asn 
            340                 345                 350         


Val Ala Tyr His Asn Ser Leu His Ala Ala Asp Val Ala Gln Ser Thr 
        355                 360                 365             


His Val Leu Leu Ala Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu 
    370                 375                 380                 


Glu Ile Leu Ala Ala Leu Phe Ala Ser Ala Ile His Asp Val Asp His 
385                 390                 395                 400 


Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala 
                405                 410                 415     


Leu Met Tyr Asn Asp Ala Ser Val Leu Glu Asn His His Leu Ala Val 
            420                 425                 430         


Gly Phe Lys Leu Leu Gln Ala Glu Asn Cys Asp Ile Phe Gln Asn Leu 
        435                 440                 445             


Ser Ala Lys Gln Arg Leu Ser Leu Arg Arg Met Val Ile Asp Met Val 
    450                 455                 460                 


Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys 
465                 470                 475                 480 


Thr Met Val Glu Thr Lys Lys Val Thr Ser Leu Gly Val Leu Leu Leu 
                485                 490                 495     


Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Leu Val His Cys 
            500                 505                 510         


Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Pro Leu Tyr Arg Gln Trp 
        515                 520                 525             


Thr Asp Arg Ile Met Ala Glu Phe Phe Gln Gln Gly Asp Arg Glu Arg 
    530                 535                 540                 


Glu Ser Gly Leu Asp Ile Ser Pro Met Cys Asp Lys His Thr Ala Ser 
545                 550                 555                 560 


Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Ala His Pro Leu 
                565                 570                 575     


Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Leu Leu 
            580                 585                 590         


Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Lys Ile Pro Arg 
        595                 600                 605             


Ser Pro Ser Asp Leu Thr Asn Pro Glu Arg Asp Gly Pro Asp Arg Phe 
    610                 615                 620                 


Gln Phe Glu Leu Thr Leu Glu Glu Ala Glu Glu Glu Asp Glu Glu Glu 
625                 630                 635                 640 


Glu Glu Glu Gly Glu Glu Thr Ala Leu Ala Lys Glu Ala Leu Glu Leu 
                645                 650                 655     


Pro Asp Thr Glu Leu Leu Ser Pro Glu Ala Gly Pro Asp Pro Gly Asp 
            660                 665                 670         


Leu Pro Leu Asp Asn Gln Arg Thr 
        675                 680 


<210>  15
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Glu Ala Glu Gly Ser Ser Ala Pro Ala Arg Ala Gly Ser Gly Glu 
1               5                   10                  15      


Gly Ser Asp Ser Ala Gly Gly Ala Thr Leu Lys Ala Pro Lys His Leu 
            20                  25                  30          


Trp Arg His Glu Gln His His Gln Tyr Pro Leu Arg Gln Pro Gln Phe 
        35                  40                  45              


Arg Leu Leu His Pro His His His Leu Pro Pro Pro Pro Pro Pro Ser 
    50                  55                  60                  


Pro Gln Pro Gln Pro Gln Cys Pro Leu Gln Pro Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Leu Pro Pro Pro Pro Pro Pro Pro Gly Ala Ala Arg Gly Arg Tyr Ala 
                85                  90                  95      


Ser Ser Gly Ala Thr Gly Arg Val Arg His Arg Gly Tyr Ser Asp Thr 
            100                 105                 110         


Glu Arg Tyr Leu Tyr Cys Arg Ala Met Asp Arg Thr Ser Tyr Ala Val 
        115                 120                 125             


Glu Thr Gly His Arg Pro Gly Leu Lys Lys Ser Arg Met Ser Trp Pro 
    130                 135                 140                 


Ser Ser Phe Gln Gly Leu Arg Arg Phe Asp Val Asp Asn Gly Thr Ser 
145                 150                 155                 160 


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
                165                 170                 175     


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
            180                 185                 190         


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
        195                 200                 205             


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
    210                 215                 220                 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
225                 230                 235                 240 


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
                245                 250                 255     


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala 
            260                 265                 270         


Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu 
        275                 280                 285             


Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala 
    290                 295                 300                 


Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser 
305                 310                 315                 320 


Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr 
                325                 330                 335     


Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys 
            340                 345                 350         


Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys 
        355                 360                 365             


Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe 
    370                 375                 380                 


Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp 
385                 390                 395                 400 


Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly 
                405                 410                 415     


Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp 
            420                 425                 430         


Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu 
        435                 440                 445             


Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn 
    450                 455                 460                 


Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr 
465                 470                 475                 480 


Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile 
                485                 490                 495     


Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln 
            500                 505                 510         


Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser 
        515                 520                 525             


Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln 
    530                 535                 540                 


Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln 
545                 550                 555                 560 


Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser 
                565                 570                 575     


Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys 
            580                 585                 590         


Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg 
        595                 600                 605             


Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro 
    610                 615                 620                 


Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu 
625                 630                 635                 640 


Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile 
                645                 650                 655     


Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val 
            660                 665                 670         


Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp 
        675                 680                 685             


Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn 
    690                 695                 700                 


Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro 
705                 710                 715                 720 


Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe 
                725                 730                 735     


Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser 
            740                 745                 750         


Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu 
        755                 760                 765             


Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val 
    770                 775                 780                 


Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys 
785                 790                 795                 800 


Val Ile Asp Asp Arg Ser Pro Asp Thr 
                805                 


<210>  16
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Met His Val Asn Asn Phe Pro Phe Arg Arg His Ser Trp Ile Cys 
1               5                   10                  15      


Phe Asp Val Asp Asn Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro 
            20                  25                  30          


Met Thr Ser Pro Gly Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His 
        35                  40                  45              


Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp 
    50                  55                  60                  


Leu Ser Pro Lys Ser Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile 
65                  70                  75                  80  


His Gly Asp Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser 
                85                  90                  95      


Leu Arg Thr Val Arg Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp 
            100                 105                 110         


Arg Ala Pro Ser Lys Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn 
        115                 120                 125             


Lys Ala Thr Ile Thr Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr 
    130                 135                 140                 


Leu Glu Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr 
145                 150                 155                 160 


Arg His Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu 
                165                 170                 175     


Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln 
            180                 185                 190         


Val Ser Glu Phe Ile Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val 
        195                 200                 205             


Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro 
    210                 215                 220                 


Met Ser Gln Ile Ser Gly Val Lys Lys Leu Met His Ser Ser Ser Leu 
225                 230                 235                 240 


Thr Asn Ser Ser Ile Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp 
                245                 250                 255     


Val Leu Ala Lys Glu Leu Glu Asp Val Asn Lys Trp Gly Leu His Val 
            260                 265                 270         


Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met 
        275                 280                 285             


His Thr Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro 
    290                 295                 300                 


Val Asp Thr Leu Ile Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His 
305                 310                 315                 320 


Ala Asp Val Ala Tyr His Asn Asn Ile His Ala Ala Asp Val Val Gln 
                325                 330                 335     


Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr 
            340                 345                 350         


Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val 
        355                 360                 365             


Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu 
    370                 375                 380                 


Leu Ala Leu Met Tyr Asn Asp Ser Ser Val Leu Glu Asn His His Leu 
385                 390                 395                 400 


Ala Val Gly Phe Lys Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln 
                405                 410                 415     


Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp 
            420                 425                 430         


Ile Val Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp 
        435                 440                 445             


Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu 
    450                 455                 460                 


Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val 
465                 470                 475                 480 


His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg 
                485                 490                 495     


Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg 
            500                 505                 510         


Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Asn 
        515                 520                 525             


Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His 
    530                 535                 540                 


Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp 
545                 550                 555                 560 


Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile 
                565                 570                 575     


Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln 
            580                 585                 590         


Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly 
        595                 600                 605             


Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr 
    610                 615                 620                 


Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr 
625                 630                 635                 640 


Glu Ile Pro Leu Asp Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu 
                645                 650                 655     


Glu Glu Ser Gln Pro Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp 
            660                 665                 670         


Thr 
    


<210>  17
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu 
1               5                   10                  15      


Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg 
            20                  25                  30          


Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys 
        35                  40                  45              


Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr 
    50                  55                  60                  


Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp 
65                  70                  75                  80  


Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser 
                85                  90                  95      


Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr 
            100                 105                 110         


His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile 
        115                 120                 125             


Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro 
    130                 135                 140                 


Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser 
145                 150                 155                 160 


Gly Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile 
                165                 170                 175     


Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu 
            180                 185                 190         


Leu Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu 
        195                 200                 205             


Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln 
    210                 215                 220                 


Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile 
225                 230                 235                 240 


Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr 
                245                 250                 255     


His Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu 
            260                 265                 270         


Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu 
        275                 280                 285             


Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val 
    290                 295                 300                 


Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr 
305                 310                 315                 320 


Asn Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys 
                325                 330                 335     


Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys 
            340                 345                 350         


Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr 
        355                 360                 365             


Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val 
    370                 375                 380                 


Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr 
385                 390                 395                 400 


Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu 
                405                 410                 415     


Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg 
            420                 425                 430         


Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly 
        435                 440                 445             


Met Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys 
    450                 455                 460                 


Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr 
465                 470                 475                 480 


Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu 
                485                 490                 495     


Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser 
            500                 505                 510         


Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys 
        515                 520                 525             


Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu 
    530                 535                 540                 


Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser 
545                 550                 555                 560 


Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp 
                565                 570                 575     


Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro 
            580                 585                 590         


Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
        595                 600                 


<210>  18
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Lys Glu Gln Pro Ser Cys Ala Gly Thr Gly His Pro Met Ala Gly 
1               5                   10                  15      


Tyr Gly Arg Met Ala Pro Phe Glu Leu Ala Ser Gly Pro Val Lys Arg 
            20                  25                  30          


Leu Arg Thr Glu Ser Pro Phe Pro Cys Leu Phe Ala Glu Glu Ala Tyr 
        35                  40                  45              


Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu Asp 
    50                  55                  60                  


Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala Ser 
65                  70                  75                  80  


Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu 
                85                  90                  95      


Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr Phe 
            100                 105                 110         


Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys Glu 
        115                 120                 125             


Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys Lys 
    130                 135                 140                 


Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe Gly 
145                 150                 155                 160 


Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp Val 
                165                 170                 175     


Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly Asn 
            180                 185                 190         


Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp Leu 
        195                 200                 205             


Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu Met 
    210                 215                 220                 


Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn Ile 
225                 230                 235                 240 


His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr Pro 
                245                 250                 255     


Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe 
            260                 265                 270         


Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe 
        275                 280                 285             


Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser Ser 
    290                 295                 300                 


Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu 
305                 310                 315                 320 


Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln Ser 
                325                 330                 335     


Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser Lys 
            340                 345                 350         


His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys 
        355                 360                 365             


Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile 
    370                 375                 380                 


Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr 
385                 390                 395                 400 


Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu 
                405                 410                 415     


Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile Ser 
            420                 425                 430         


Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val Gly 
        435                 440                 445             


Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu 
    450                 455                 460                 


Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg 
465                 470                 475                 480 


Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro Asp 
                485                 490                 495     


Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe Glu 
            500                 505                 510         


Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser Gly 
        515                 520                 525             


Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu Cys 
    530                 535                 540                 


Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val Glu 
545                 550                 555                 560 


Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys Val 
                565                 570                 575     


Ile Asp Asp Arg Ser Pro Asp Thr 
            580                 


<210>  19
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His 
1               5                   10                  15      


Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser 
            20                  25                  30          


Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr 
        35                  40                  45              


Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly 
    50                  55                  60                  


Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro 
65                  70                  75                  80  


Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu 
                85                  90                  95      


Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu 
            100                 105                 110         


Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu 
        115                 120                 125             


Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr 
    130                 135                 140                 


Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His 
145                 150                 155                 160 


Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu 
                165                 170                 175     


Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala 
            180                 185                 190         


Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser 
        195                 200                 205             


Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn 
    210                 215                 220                 


Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln 
                245                 250                 255     


Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp 
            260                 265                 270         


Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu 
        275                 280                 285             


Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser 
    290                 295                 300                 


Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser 
305                 310                 315                 320 


Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile 
                325                 330                 335     


Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met 
            340                 345                 350         


Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser 
        355                 360                 365             


Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp 
    370                 375                 380                 


Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu 
385                 390                 395                 400 


Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro 
                405                 410                 415     


Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe 
            420                 425                 430         


Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys 
        435                 440                 445             


Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys 
    450                 455                 460                 


Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu 
465                 470                 475                 480 


Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu 
                485                 490                 495     


Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
            500                 505         


<210>  20
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Gln Gln Thr Ser Pro Asp Thr Leu Thr Val Pro Glu Val Asp 
1               5                   10                  15      


Asn Pro His Cys Pro Asn Pro Trp Leu Asn Glu Asp Leu Val Lys Ser 
            20                  25                  30          


Leu Arg Glu Asn Leu Leu Gln His Glu Lys Ser Lys Thr Ala Arg Lys 
        35                  40                  45              


Ser Val Ser Pro Lys Leu Ser Pro Val Ile Ser Pro Arg Asn Ser Pro 
    50                  55                  60                  


Arg Leu Leu Arg Arg Met Leu Leu Ser Ser Asn Ile Pro Lys Gln Arg 
65                  70                  75                  80  


Arg Phe Thr Val Ala His Thr Cys Phe Asp Val Asp Asn Gly Thr Ser 
                85                  90                  95      


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
            100                 105                 110         


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
        115                 120                 125             


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
    130                 135                 140                 


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
145                 150                 155                 160 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
                165                 170                 175     


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
            180                 185                 190         


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala 
        195                 200                 205             


Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu 
    210                 215                 220                 


Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala 
225                 230                 235                 240 


Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser 
                245                 250                 255     


Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr 
            260                 265                 270         


Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys 
        275                 280                 285             


Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys 
    290                 295                 300                 


Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe 
305                 310                 315                 320 


Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp 
                325                 330                 335     


Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly 
            340                 345                 350         


Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp 
        355                 360                 365             


Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu 
    370                 375                 380                 


Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn 
385                 390                 395                 400 


Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr 
                405                 410                 415     


Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile 
            420                 425                 430         


Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln 
        435                 440                 445             


Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser 
    450                 455                 460                 


Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln 
465                 470                 475                 480 


Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln 
                485                 490                 495     


Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser 
            500                 505                 510         


Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys 
        515                 520                 525             


Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg 
    530                 535                 540                 


Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro 
545                 550                 555                 560 


Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu 
                565                 570                 575     


Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile 
            580                 585                 590         


Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val 
        595                 600                 605             


Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp 
    610                 615                 620                 


Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn 
625                 630                 635                 640 


Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro 
                645                 650                 655     


Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe 
            660                 665                 670         


Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser 
        675                 680                 685             


Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu 
    690                 695                 700                 


Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val 
705                 710                 715                 720 


Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys 
                725                 730                 735     


Val Ile Asp Asp Arg Ser Pro Asp Thr 
            740                 745 


<210>  21
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Gln Gln Thr Ser Pro Asp Thr Leu Thr Val Pro Glu Val Asp 
1               5                   10                  15      


Asn Pro His Cys Pro Asn Pro Trp Leu Asn Glu Asp Leu Val Lys Ser 
            20                  25                  30          


Leu Arg Glu Asn Leu Leu Gln His Glu Lys Ser Lys Thr Ala Arg Lys 
        35                  40                  45              


Ser Val Ser Pro Lys Leu Ser Pro Val Ile Ser Pro Arg Asn Ser Pro 
    50                  55                  60                  


Arg Leu Leu Arg Arg Met Leu Leu Ser Ser Asn Ile Pro Lys Gln Arg 
65                  70                  75                  80  


Arg Phe Thr Val Ala His Thr Cys Phe Asp Val Asp Asn Gly Thr Ser 
                85                  90                  95      


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
            100                 105                 110         


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
        115                 120                 125             


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
    130                 135                 140                 


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
145                 150                 155                 160 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
                165                 170                 175     


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
            180                 185                 190         


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Gly Leu Tyr 
        195                 200                 205             


Asn Gly Ile Ile Ala Phe Leu 
    210                 215 


<210>  22
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Pro Glu Ala Asn Tyr Leu Leu Ser Val Ser Trp Gly Tyr Ile Lys 
1               5                   10                  15      


Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser 
            20                  25                  30          


Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr Phe Leu Asp 
        35                  40                  45              


Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys Glu 
    50                  55                  60                  


Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys Lys Leu Met 
65                  70                  75                  80  


His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe Gly Val Lys 
                85                  90                  95      


Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp Val Asn Lys 
            100                 105                 110         


Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg Pro 
        115                 120                 125             


Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp Leu Leu Lys 
    130                 135                 140                 


Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu Met Thr Leu 
145                 150                 155                 160 


Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn Ile His Ala 
                165                 170                 175     


Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu 
            180                 185                 190         


Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ser 
        195                 200                 205             


Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile 
    210                 215                 220                 


Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser Ser Val Leu 
225                 230                 235                 240 


Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Glu Asn 
                245                 250                 255     


Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu Arg 
            260                 265                 270         


Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser Lys His Met 
        275                 280                 285             


Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr 
    290                 295                 300                 


Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val 
305                 310                 315                 320 


Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro 
                325                 330                 335     


Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe 
            340                 345                 350         


Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met 
        355                 360                 365             


Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile 
    370                 375                 380                 


Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His 
385                 390                 395                 400 


Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu Trp 
                405                 410                 415     


Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp Pro 
            420                 425                 430         


Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu Thr 
        435                 440                 445             


Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser Gln 
    450                 455                 460                 


Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr Gln 
465                 470                 475                 480 


Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val Glu Glu Glu 
                485                 490                 495     


Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys Val Ile Asp 
            500                 505                 510         


Asp Arg Ser Pro Asp Thr 
        515             


<210>  23
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Phe Val Trp Asp Pro Leu Gly Ala Thr Val Pro Gly Pro Ser 
1               5                   10                  15      


Thr Arg Ala Lys Ser Arg Leu Arg Phe Ser Lys Ser Tyr Ser Phe Asp 
            20                  25                  30          


Val Asp Asn Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro Met Thr 
        35                  40                  45              


Ser Pro Gly Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His Ser Gln 
    50                  55                  60                  


Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser 
65                  70                  75                  80  


Pro Lys Ser Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile His Gly 
                85                  90                  95      


Asp Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg 
            100                 105                 110         


Thr Val Arg Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala 
        115                 120                 125             


Pro Ser Lys Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn Lys Ala 
    130                 135                 140                 


Thr Ile Thr Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu 
145                 150                 155                 160 


Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr Arg His 
                165                 170                 175     


Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg 
            180                 185                 190         


Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser 
        195                 200                 205             


Glu Phe Ile Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile 
    210                 215                 220                 


Pro Ser Pro Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser 
225                 230                 235                 240 


Gln Ile Ser Gly Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn 
                245                 250                 255     


Ser Ser Ile Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu 
            260                 265                 270         


Ala Lys Glu Leu Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg 
        275                 280                 285             


Ile Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr 
    290                 295                 300                 


Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp 
305                 310                 315                 320 


Thr Leu Ile Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp 
                325                 330                 335     


Val Ala Tyr His Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr 
            340                 345                 350         


His Val Leu Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu 
        355                 360                 365             


Glu Ile Leu Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His 
    370                 375                 380                 


Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala 
385                 390                 395                 400 


Leu Met Tyr Asn Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val 
                405                 410                 415     


Gly Phe Lys Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu 
            420                 425                 430         


Thr Lys Lys Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val 
        435                 440                 445             


Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys 
    450                 455                 460                 


Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu 
465                 470                 475                 480 


Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys 
                485                 490                 495     


Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp 
            500                 505                 510         


Thr Asp Arg Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg 
        515                 520                 525             


Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser 
    530                 535                 540                 


Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu 
545                 550                 555                 560 


Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu 
                565                 570                 575     


Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln 
            580                 585                 590         


Ser Pro Ser Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln 
        595                 600                 605             


Thr Glu Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser 
    610                 615                 620                 


Asp Thr Glu Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys 
625                 630                 635                 640 


Ser Asp Ser Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile 
                645                 650                 655     


Pro Leu Asp Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu 
            660                 665                 670         


Ser Gln Pro Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
        675                 680                 685         


<210>  24
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Ile Ile Met Lys Pro Arg Ser Arg Ser Thr Ser Ser Leu Arg 
1               5                   10                  15      


Thr Ala Glu Ala Val Cys Glu Asp Val Asp Asn Gly Thr Ser Ala Gly 
            20                  25                  30          


Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu Ile Leu 
        35                  40                  45              


Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg 
    50                  55                  60                  


Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg Asn Ser 
65                  70                  75                  80  


Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr Pro Phe 
                85                  90                  95      


Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe Ala Ala 
            100                 105                 110         


Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro Met Cys 
        115                 120                 125             


Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala Tyr Gln 
    130                 135                 140                 


Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu Asp Gln 
145                 150                 155                 160 


Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala Ser Asn 
                165                 170                 175     


Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met 
            180                 185                 190         


Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr Phe Leu 
        195                 200                 205             


Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys 
    210                 215                 220                 


Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys Lys Leu 
225                 230                 235                 240 


Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe Gly Val 
                245                 250                 255     


Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp Val Asn 
            260                 265                 270         


Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg 
        275                 280                 285             


Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp Leu Leu 
    290                 295                 300                 


Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu Met Thr 
305                 310                 315                 320 


Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn Ile His 
                325                 330                 335     


Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr Pro Ala 
            340                 345                 350         


Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala 
        355                 360                 365             


Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu 
    370                 375                 380                 


Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser Ser Val 
385                 390                 395                 400 


Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Glu 
                405                 410                 415     


Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu 
            420                 425                 430         


Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser Lys His 
        435                 440                 445             


Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val 
    450                 455                 460                 


Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln 
465                 470                 475                 480 


Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys 
                485                 490                 495     


Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu Phe 
            500                 505                 510         


Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile Ser Pro 
        515                 520                 525             


Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val Gly Phe 
    530                 535                 540                 


Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val 
545                 550                 555                 560 


His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu 
                565                 570                 575     


Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp 
            580                 585                 590         


Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu 
        595                 600                 605             


Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser 
    610                 615                 620                 


Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr 
625                 630                 635                 640 


Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val Glu Glu 
                645                 650                 655     


Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys Val Ile 
            660                 665                 670         


Asp Asp Arg Ser Pro Asp Thr 
        675                 


<210>  25
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Lys Arg Asn Thr Cys Asp Leu Leu Ser Arg Ser Lys Ser Ala Ser 
1               5                   10                  15      


Glu Glu Thr Leu His Ser Ser Asn Glu Glu Glu Asp Pro Phe Arg Gly 
            20                  25                  30          


Met Glu Pro Tyr Leu Val Arg Arg Leu Ser Cys Arg Asn Ile Gln Leu 
        35                  40                  45              


Pro Pro Leu Ala Phe Arg Gln Leu Glu Gln Ala Asp Leu Lys Ser Glu 
    50                  55                  60                  


Ser Glu Asn Ile Gln Arg Pro Thr Ser Leu Pro Leu Lys Ile Leu Pro 
65                  70                  75                  80  


Leu Ile Ala Ile Thr Ser Ala Glu Ser Ser Gly Phe Asp Val Asp Asn 
                85                  90                  95      


Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly 
            100                 105                 110         


Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu 
        115                 120                 125             


Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser 
    130                 135                 140                 


Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu 
145                 150                 155                 160 


Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg 
                165                 170                 175     


Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys 
            180                 185                 190         


Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr 
        195                 200                 205             


Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp 
    210                 215                 220                 


Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser 
225                 230                 235                 240 


Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr 
                245                 250                 255     


His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile 
            260                 265                 270         


Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro 
        275                 280                 285             


Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser 
    290                 295                 300                 


Gly Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile 
305                 310                 315                 320 


Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu 
                325                 330                 335     


Leu Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu 
            340                 345                 350         


Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln 
        355                 360                 365             


Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile 
    370                 375                 380                 


Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr 
385                 390                 395                 400 


His Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu 
                405                 410                 415     


Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu 
            420                 425                 430         


Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val 
        435                 440                 445             


Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr 
    450                 455                 460                 


Asn Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys 
465                 470                 475                 480 


Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys 
                485                 490                 495     


Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr 
            500                 505                 510         


Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val 
        515                 520                 525             


Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr 
    530                 535                 540                 


Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu 
545                 550                 555                 560 


Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg 
                565                 570                 575     


Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly 
            580                 585                 590         


Met Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys 
        595                 600                 605             


Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr 
    610                 615                 620                 


Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu 
625                 630                 635                 640 


Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser 
                645                 650                 655     


Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys 
            660                 665                 670         


Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu 
        675                 680                 685             


Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser 
    690                 695                 700                 


Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro 
                725                 730                 735     


Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
            740                 745             


<210>  26
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Gln Gln Thr Ser Pro Asp Thr Leu Thr Val Pro Glu Val Asp 
1               5                   10                  15      


Asn Pro His Cys Pro Asn Pro Trp Leu Asn Glu Asp Leu Val Lys Ser 
            20                  25                  30          


Leu Arg Glu Asn Leu Leu Gln His Glu Lys Ser Lys Thr Ala Arg Lys 
        35                  40                  45              


Ser Val Ser Pro Lys Leu Ser Pro Val Ile Ser Pro Arg Asn Ser Pro 
    50                  55                  60                  


Arg Leu Leu Arg Arg Met Leu Leu Ser Ser Asn Ile Pro Lys Gln Arg 
65                  70                  75                  80  


Arg Phe Thr Val Ala His Thr Cys Phe Asp Val Asp Asn Gly Thr Ser 
                85                  90                  95      


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
            100                 105                 110         


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
        115                 120                 125             


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
    130                 135                 140                 


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
145                 150                 155                 160 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
                165                 170                 175     


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
            180                 185                 190         


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Gly Ser Trp 
        195                 200                 205             


Met Glu Leu Asn Pro Tyr Thr Leu Leu Asp Met 
    210                 215                 


