                         SEQUENCE LISTING

<110>  The Broad Institute, Inc.
 
<120>  SUPERNEGATIVELY CHARGED PROTEINS AND USES THEREOF

<130>  B1195.70053WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/795,912
<151>  2019-01-23

<160>  90    

<170>  PatentIn version 3.5

<210>  1
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Met Gly Ala Ser Asp Ala Ala Val Asp Thr Ser Ser Glu Ile Thr Thr 
1               5                   10                  15      


Lys Asp Leu Lys Glu Lys Lys Glu Val Val Glu Glu Ala Glu Asn Gly 
            20                  25                  30          


Arg Asp Ala Pro Ala Asn Gly Asn Ala Glu Asn Glu Glu Asn Gly Glu 
        35                  40                  45              


Gln Glu Ala Asp Asn Glu Val Asp Glu Glu Glu Glu Glu Gly Gly Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Glu Glu Gly Asp Gly Glu Glu Glu Asp Gly Asp 
65                  70                  75                  80  


Glu Asp Glu Glu Ala Glu Ser Ala Thr Gly Lys Arg Ala Ala Glu Asp 
                85                  90                  95      


Asp Glu Asp Asp Asp Val Asp Thr Lys Lys Gln Lys Thr Asp Glu Asp 
            100                 105                 110         


Asp Thr 
        


<210>  2
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Gly Ala Ser Asp Ala Ala Val Asp Thr Ser Ser Glu Ile Thr Thr 
1               5                   10                  15      


Lys Asp Leu Lys Glu Lys Lys Glu Val Val Glu Glu Ala Glu Asn Gly 
            20                  25                  30          


Arg Asp Ala Pro Ala Asn Gly Asn Ala Glu Asn Glu Glu Asn Gly Glu 
        35                  40                  45              


Gln Glu Ala Asp Asn Glu Val Asp Glu Glu Glu Glu Glu Gly Gly Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Glu Glu Gly Asp Gly Glu Glu Glu Asp Gly Asp 
65                  70                  75                  80  


Glu Asp Glu Glu Ala Glu Ser Ala Thr Gly Lys Arg Ala Ala Glu Asp 
                85                  90                  95      


Asp Glu Asp Asp Asp Val Asp Thr 
            100                 


<210>  3
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Met Gly Ala Glu Asn Glu Glu Asn Gly Glu Gln Glu Ala Asp Asn Glu 
1               5                   10                  15      


Val Asp Glu Glu Glu Glu Glu Gly Gly Glu Glu Glu Glu Glu Glu Glu 
            20                  25                  30          


Glu Gly Asp Gly Glu Glu Glu Asp Gly Asp Glu Asp Glu Glu Ala Glu 
        35                  40                  45              


Ser Ala Thr Gly Lys Arg Ala Ala Glu Asp Asp Glu Asp Asp Asp Val 
    50                  55                  60                  


Asp Thr Lys Lys Gln Lys Thr Asp Glu Asp Asp 
65                  70                  75  


<210>  4
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Met Ala Val Phe His Asp Glu Val Glu Ile Glu Asp Phe Gln Tyr Asp 
1               5                   10                  15      


Glu Asp Ser Glu Thr Tyr Phe Tyr Pro Cys Pro Cys Gly Asp Asn Phe 
            20                  25                  30          


Ser Ile Thr Lys Glu Asp Leu Glu Asn Gly Glu Asp Val Ala Thr Cys 
        35                  40                  45              


Pro Ser Cys Ser Leu Ile Ile Lys Val Ile Tyr Asp Lys Asp Gln Phe 
    50                  55                  60                  


Val Cys Gly Glu Thr Val Pro Ala Pro Ser Ala Asn Lys Glu Leu Val 
65                  70                  75                  80  


Lys Cys 
        


<210>  5
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Met Asp Ala Leu Glu Gly Glu Ser Phe Ala Leu Ser Phe Ser Ser Ala 
1               5                   10                  15      


Ser Asp Ala Glu Phe Asp Ala Val Val Gly Tyr Leu Glu Asp Ile Ile 
            20                  25                  30          


Met Asp Asp Glu Phe Gln Leu Leu Gln Arg Asn Phe Met Asp Lys Tyr 
        35                  40                  45              


Tyr Leu Glu Phe Glu Asp Thr Glu Glu Asn Lys Leu Ile Tyr Thr Pro 
    50                  55                  60                  


Ile Phe Asn Glu Tyr Ile Ser Leu Val Glu Lys Tyr Ile Glu Glu Gln 
65                  70                  75                  80  


Leu Leu Gln Arg Ile Pro Glu Phe Asn Met Ala Ala Phe Thr Thr Thr 
                85                  90                  95      


Leu Gln His His Lys Asp Glu Val Ala Gly Asp Ile Phe Asp Met Leu 
            100                 105                 110         


Leu Thr Phe Thr Asp Phe Leu Ala Phe Lys Glu Met Phe Leu Asp Tyr 
        115                 120                 125             


Arg Ala Glu Lys Glu Gly Arg Gly Leu Asp Leu Ser Ser Gly Leu Val 
    130                 135                 140                 


Val Thr Ser Leu Cys Lys Ser Ser Ser Leu Pro Ala Ser Gln Asn Asn 
145                 150                 155                 160 


Leu Arg His 
            


<210>  6
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Met Ser Glu Leu Glu Lys Ala Met Val Ala Leu Ile Asp Val Phe His 
1               5                   10                  15      


Gln Tyr Ser Gly Arg Glu Gly Asp Lys His Lys Leu Lys Lys Ser Glu 
            20                  25                  30          


Leu Lys Glu Leu Ile Asn Asn Glu Leu Ser His Phe Leu Glu Glu Ile 
        35                  40                  45              


Lys Glu Gln Glu Val Val Asp Lys Val Met Glu Thr Leu Asp Asn Asp 
    50                  55                  60                  


Gly Asp Gly Glu Cys Asp Phe Gln Glu Phe Met Ala Phe Val Ala Met 
65                  70                  75                  80  


Val Thr Thr Ala Cys His Glu Phe Phe Glu His Glu 
                85                  90          


<210>  7
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 
            20                  25                  30          


Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro 
        35                  40                  45              


Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala 
    50                  55                  60                  


Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala 
                85                  90                  95      


Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg 
            100                 105                 110         


Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu 
        115                 120                 125             


Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp 
    130                 135                 140                 


Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys 
145                 150                 155                 160 


Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp 
                165                 170                 175     


Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu 
            180                 185                 190         


Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 
        195                 200                 205             


Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 
    210                 215                 220                 


Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 
225                 230                 235                 240 


Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 
                245                 250                 255     


Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 
            260                 265                 270         


Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 
        275                 280                 285             


Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 
    290                 295                 300                 


Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 
305                 310                 315                 320 


Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 
                325                 330                 335     


Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 
            340                 345                 350         


Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 
        355                 360                 365             


Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 
    370                 375                 380                 


Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 
385                 390                 395                 400 


Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 
                405                 410                 415     


Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 
            420                 425                 430         


Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 
        435                 440                 445             


Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile 
    450                 455                 460                 


Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly 
465                 470                 475                 480 


Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu 
                485                 490                 495     


Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu 
            500                 505                 510         


Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro 
        515                 520                 525             


Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr 
    530                 535                 540                 


Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala 
545                 550                 555                 560 


Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu 
                565                 570                 575     


Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala 
            580                 585                 590         


Glu Gln Met Glu Asn Pro Asp Leu 
        595                 600 


<210>  8
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 
1               5                   10          


<210>  11
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser 
            20      


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Val Pro Phe Leu Leu Glu Pro Asp Asn Ile Asn Gly Lys Thr Cys 
1               5                   10                  15  


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala 
1               5                   10          


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Met Lys Ile Ile Glu Gln Leu Pro Ser Ala 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Val Arg His Lys Leu Lys Arg Val Gly Ser 
1               5                   10  


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Gly His Gly Thr Gly Ser Thr Gly Ser Gly Ser Ser 
1               5                   10          


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Met Ser Arg Pro Asp Pro Ala 
1               5           


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Gly Gly Ser Met 
1               


<210>  20
<211>  4104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  20
atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg       60

atcactgatg attataaggt tccgtctaaa aagttcaagg ttctgggaaa tacagaccgc      120

cacagtatca aaaaaaatct tataggggct cttttatttg gcagtggaga gacagcggaa      180

gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt      240

tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga      300

cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga      360

aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa      420

aaattggcag attctactga taaagcggat ttgcgcttaa tctatttggc cttagcgcat      480

atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga taatagtgat      540

gtggacaaac tatttatcca gttggtacaa atctacaatc aattatttga agaaaaccct      600

attaacgcaa gtagagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga      660

cgattagaaa atctcattgc tcagctcccc ggtgagaaga gaaatggctt gtttgggaat      720

ctcattgctt tgtcattggg attgacccct aattttaaat caaattttga tttggcagaa      780

gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa tttattggcg      840

caaattggag atcaatatgc tgatttgttt ttggcagcta agaatttatc agatgctatt      900

ttactttcag atatcctaag agtaaatagt gaaataacta aggctcccct atcagcttca      960

atgattaagc gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga     1020

caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca     1080

ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta     1140

gaaaaaatgg atggtactga ggaattattg gtgaaactaa atcgtgaaga tttgctgcgc     1200

aagcaacgga cctttgacaa cggctctatt ccccatcaaa ttcacttggg tgagctgcat     1260

gctattttga gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt     1320

gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt     1380

cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa     1440

gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa     1500

aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta ttttacggtt     1560

tataacgaat tgacaaaggt caaatatgtt actgagggaa tgcgaaaacc agcatttctt     1620

tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc     1680

gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt     1740

tcaggagttg aagatagatt taatgcttca ttaggcgcct accatgattt gctaaaaatt     1800

attaaagata aagatttttt ggataatgaa gaaaatgaag atatcttaga ggatattgtt     1860

ttaacattga ccttatttga agataggggg atgattgagg aaagacttaa aacatatgct     1920

cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga     1980

cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta     2040

gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat     2100

agtttgacat ttaaagaaga tattcaaaaa gcacaggtgt ctggacaagg ccatagttta     2160

catgaacaga ttgctaactt agctggcagt cctgctatta aaaaaggtat tttacagact     2220

gtaaaaattg ttgatgaact ggtcaaagta atggggcata agccagaaaa tatcgttatt     2280

gaaatggcac gtgaaaatca gacaactcaa aagggccaga aaaattcgcg agagcgtatg     2340

aaacgaatcg aagaaggtat caaagaatta ggaagtcaga ttcttaaaga gcatcctgtt     2400

gaaaatactc aattgcaaaa tgaaaagctc tatctctatt atctacaaaa tggaagagac     2460

atgtatgtgg accaagaatt agatattaat cgtttaagtg attatgatgt cgatcacatt     2520

gttccacaaa gtttcattaa agacgattca atagacaata aggtactaac gcgttctgat     2580

aaaaatcgtg gtaaatcgga taacgttcca agtgaagaag tagtcaaaaa gatgaaaaac     2640

tattggagac aacttctaaa cgccaagtta atcactcaac gtaagtttga taatttaacg     2700

aaagctgaac gtggaggttt gagtgaactt gataaagctg gttttatcaa acgccaattg     2760

gttgaaactc gccaaatcac taagcatgtg gcacaaattt tggatagtcg catgaatact     2820

aaatacgatg aaaatgataa acttattcga gaggttaaag tgattacctt aaaatctaaa     2880

ttagtttctg acttccgaaa agatttccaa ttctataaag tacgtgagat taacaattac     2940

catcatgccc atgatgcgta tctaaatgcc gtcgttggaa ctgctttgat taagaaatat     3000

ccaaaacttg aatcggagtt tgtctatggt gattataaag tttatgatgt tcgtaaaatg     3060

attgctaagt ctgagcaaga aataggcaaa gcaaccgcaa aatatttctt ttactctaat     3120

atcatgaact tcttcaaaac agaaattaca cttgcaaatg gagagattcg caaacgccct     3180

ctaatcgaaa ctaatgggga aactggagaa attgtctggg ataaagggcg agattttgcc     3240

acagtgcgca aagtattgtc catgccccaa gtcaatattg tcaagaaaac agaagtacag     3300

acaggcggat tctccaagga gtcaatttta ccaaaaagaa attcggacaa gcttattgct     3360

cgtaaaaaag actgggatcc aaaaaaatat ggtggttttg atagtccaac ggtagcttat     3420

tcagtcctag tggttgctaa ggtggaaaaa gggaaatcga agaagttaaa atccgttaaa     3480

gagttactag ggatcacaat tatggaaaga agttcctttg aaaaaaatcc gattgacttt     3540

ttagaagcta aaggatataa ggaagttaaa aaagacttaa tcattaaact acctaaatat     3600

agtctttttg agttagaaaa cggtcgtaaa cggatgctgg ctagtgccgg agaattacaa     3660

aaaggaaatg agctggctct gccaagcaaa tatgtgaatt ttttatattt agctagtcat     3720

tatgaaaagt tgaagggtag tccagaagat aacgaacaaa aacaattgtt tgtggagcag     3780

cataagcatt atttagatga gattattgag caaatcagtg aattttctaa gcgtgttatt     3840

ttagcagatg ccaatttaga taaagttctt agtgcatata acaaacatag agacaaacca     3900

atacgtgaac aagcagaaaa tattattcat ttatttacgt tgacgaatct tggagctccc     3960

gctgctttta aatattttga tacaacaatt gatcgtaaac gatatacgtc tacaaaagaa     4020

gttttagatg ccactcttat ccatcaatcc atcactggtc tttatgaaac acgcattgat     4080

ttgagtcagc taggaggtga ctga                                            4104


<210>  21
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  22
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  23
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  24
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  24
atggccctgt ttggctacgc acgcgtgtct accagtcaac agtcactcga tttgcaagtg       60

agggctctta aagatgccgg agtgaaggca aacagaattt ttactgataa ggccagcgga      120

agcagcacag acagagaggg gctggatctc ctgagaatga aggtaaagga gggtgatgtg      180

atcttggtca aaaaattgga tcgactgggg agagacacag ctgatatgct tcagcttatt      240

aaagagtttg acgctcaggg tgttgccgtg aggtttatcg atgacggcat ctcaaccgac      300

tcctacattg gtcttatgtt tgtgacaatt ttgtccgctg tggctcaggc tgagcggaga      360

aggattctcg aaaggacgaa tgagggacgg caagcagcta agttgaaagg tatcaaattt      420

ggcagacgaa gg                                                          432


<210>  25
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Met Ala Leu Phe Gly Tyr Ala Arg Val Ser Thr Ser Gln Gln Ser Leu 
1               5                   10                  15      


Asp Leu Gln Val Arg Ala Leu Lys Asp Ala Gly Val Lys Ala Asn Arg 
            20                  25                  30          


Ile Phe Thr Asp Lys Ala Ser Gly Ser Ser Thr Asp Arg Glu Gly Leu 
        35                  40                  45              


Asp Leu Leu Arg Met Lys Val Lys Glu Gly Asp Val Ile Leu Val Lys 
    50                  55                  60                  


Lys Leu Asp Arg Leu Gly Arg Asp Thr Ala Asp Met Leu Gln Leu Ile 
65                  70                  75                  80  


Lys Glu Phe Asp Ala Gln Gly Val Ala Val Arg Phe Ile Asp Asp Gly 
                85                  90                  95      


Ile Ser Thr Asp Ser Tyr Ile Gly Leu Met Phe Val Thr Ile Leu Ser 
            100                 105                 110         


Ala Val Ala Gln Ala Glu Arg Arg Arg Ile Leu Glu Arg Thr Asn Glu 
        115                 120                 125             


Gly Arg Gln Ala Ala Lys Leu Lys Gly Ile Lys Phe Gly Arg Arg Arg 
    130                 135                 140                 


<210>  26
<211>  414
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  26
atggcaacca ttggctacat aagggtgtct accatcgacc aaaatatcga cctgcagcgc       60

aacgctctga catccgccaa ctgcgatcgg atcttcgagg ataggatcag tggcaagatc      120

gccaaccggc ccggtctgaa gcgggctctg aagtacgtga ataagggcga tactctggtt      180

gtgtggaagt tggatcgctt gggtagatca gtgaagaatc tcgtagccct gataagcgag      240

ctgcacgaga ggggtgcaca tttccattct ctgaccgatt ccatcgatac gtctagcgcc      300

atgggccgat tcttctttta cgtcatgtcc gccctcgctg aaatggagcg cgaacttatt      360

gttgaacgga ctttggctgg actggcagcg gctagagcac agggccgact tgga            414


<210>  27
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Met Ala Thr Ile Gly Tyr Ile Arg Val Ser Thr Ile Asp Gln Asn Ile 
1               5                   10                  15      


Asp Leu Gln Arg Asn Ala Leu Thr Ser Ala Asn Cys Asp Arg Ile Phe 
            20                  25                  30          


Glu Asp Arg Ile Ser Gly Lys Ile Ala Asn Arg Pro Gly Leu Lys Arg 
        35                  40                  45              


Ala Leu Lys Tyr Val Asn Lys Gly Asp Thr Leu Val Val Trp Lys Leu 
    50                  55                  60                  


Asp Arg Leu Gly Arg Ser Val Lys Asn Leu Val Ala Leu Ile Ser Glu 
65                  70                  75                  80  


Leu His Glu Arg Gly Ala His Phe His Ser Leu Thr Asp Ser Ile Asp 
                85                  90                  95      


Thr Ser Ser Ala Met Gly Arg Phe Phe Phe Tyr Val Met Ser Ala Leu 
            100                 105                 110         


Ala Glu Met Glu Arg Glu Leu Ile Val Glu Arg Thr Leu Ala Gly Leu 
        115                 120                 125             


Ala Ala Ala Arg Ala Gln Gly Arg Leu Gly 
    130                 135             


<210>  28
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  28
atgctcattg gctatgtaag ggtcagcacc aatgaccaaa acacagactt gcaacgcaat       60

gctttggttt gcgccggatg tgaacagata tttgaagata aactgagcgg cactcggaca      120

gacagacctg ggcttaagag agcactgaaa agactgcaga agggggacac cctggtcgtc      180

tggaaactgg atcgcctcgg acgcagcatg aaacatctga ttagcctggt tggtgagctt      240

agggagagag gaatcaactt cagaagcctg accgactcca tcgacaccag tagccccatg      300

ggacgattct tcttctatgt gatgggagca cttgctgaga tggaaagaga gcttattatc      360

gaaagaacta tggctggtat cgctgctgcc cggaacaaag gcagacggtt cggcagaccg      420

ccgaagagcg gc                                                          432


<210>  29
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Met Leu Ile Gly Tyr Val Arg Val Ser Thr Asn Asp Gln Asn Thr Asp 
1               5                   10                  15      


Leu Gln Arg Asn Ala Leu Val Cys Ala Gly Cys Glu Gln Ile Phe Glu 
            20                  25                  30          


Asp Lys Leu Ser Gly Thr Arg Thr Asp Arg Pro Gly Leu Lys Arg Ala 
        35                  40                  45              


Leu Lys Arg Leu Gln Lys Gly Asp Thr Leu Val Val Trp Lys Leu Asp 
    50                  55                  60                  


Arg Leu Gly Arg Ser Met Lys His Leu Ile Ser Leu Val Gly Glu Leu 
65                  70                  75                  80  


Arg Glu Arg Gly Ile Asn Phe Arg Ser Leu Thr Asp Ser Ile Asp Thr 
                85                  90                  95      


Ser Ser Pro Met Gly Arg Phe Phe Phe Tyr Val Met Gly Ala Leu Ala 
            100                 105                 110         


Glu Met Glu Arg Glu Leu Ile Ile Glu Arg Thr Met Ala Gly Ile Ala 
        115                 120                 125             


Ala Ala Arg Asn Lys Gly Arg Arg Phe Gly Arg Pro Pro Lys Ser Gly 
    130                 135                 140                 


<210>  30
<211>  876
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu 
            20                  25                  30          


Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala 
        35                  40                  45              


Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu 
    50                  55                  60                  


Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro 
                85                  90                  95      


Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg 
            100                 105                 110         


Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala 
        115                 120                 125             


Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro 
145                 150                 155                 160 


Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Gln Ala Gly 
                165                 170                 175     


Gly Leu Gln Asp Asp Ser Ser Gly Gly Tyr Gly Asp Gly Gln Ala Ser 
            180                 185                 190         


Gly Val Glu Gly Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met 
        195                 200                 205             


Thr Ser Gln Glu Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln 
    210                 215                 220                 


Gln Thr Gln Lys Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu 
225                 230                 235                 240 


Trp Leu Asp Asn Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln 
                245                 250                 255     


Gln Leu Glu Ala Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val 
            260                 265                 270         


His Ser Tyr Leu Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys 
        275                 280                 285             


Arg Ile Lys Pro Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile 
    290                 295                 300                 


Gly Ser Gly Val Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe 
305                 310                 315                 320 


Gly Met Asp Val Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg 
                325                 330                 335     


Val Ala Thr Phe Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met 
            340                 345                 350         


Val Val Thr Gly Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln 
        355                 360                 365             


Val Asn Met Glu Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu 
    370                 375                 380                 


Ala Asn Gly Gln Ala Asp Thr Val Lys Val Pro Lys Glu Lys Asp Glu 
385                 390                 395                 400 


Met Val Glu Gln Glu Phe Asn Arg Leu Leu Glu Ala Thr Ser Tyr Leu 
                405                 410                 415     


Ser His Gln Leu Asp Phe Asn Val Leu Asn Asn Lys Pro Val Ser Leu 
            420                 425                 430         


Gly Gln Ala Leu Glu Val Val Ile Gln Leu Gln Glu Lys His Val Lys 
        435                 440                 445             


Asp Glu Gln Ile Glu His Trp Lys Lys Ile Val Lys Thr Gln Glu Glu 
    450                 455                 460                 


Leu Lys Glu Leu Leu Asn Lys Met Val Asn Leu Lys Glu Lys Ile Lys 
465                 470                 475                 480 


Glu Leu His Gln Gln Tyr Lys Glu Ala Ser Glu Val Lys Pro Pro Arg 
                485                 490                 495     


Asp Ile Thr Ala Glu Phe Leu Val Lys Ser Lys His Arg Asp Leu Thr 
            500                 505                 510         


Ala Leu Cys Lys Glu Tyr Asp Glu Leu Ala Glu Thr Gln Gly Lys Leu 
        515                 520                 525             


Glu Glu Lys Leu Gln Glu Leu Glu Ala Asn Pro Pro Ser Asp Val Tyr 
    530                 535                 540                 


Leu Ser Ser Arg Asp Arg Gln Ile Leu Asp Trp His Phe Ala Asn Leu 
545                 550                 555                 560 


Glu Phe Ala Asn Ala Thr Pro Leu Ser Thr Leu Ser Leu Lys His Trp 
                565                 570                 575     


Asp Gln Asp Asp Asp Phe Glu Phe Thr Gly Ser His Leu Thr Val Arg 
            580                 585                 590         


Asn Gly Tyr Ser Cys Val Pro Val Ala Leu Ala Glu Gly Leu Asp Ile 
        595                 600                 605             


Lys Leu Asn Thr Ala Val Arg Gln Val Arg Tyr Thr Ala Ser Gly Cys 
    610                 615                 620                 


Glu Val Ile Ala Val Asn Thr Arg Ser Thr Ser Gln Thr Phe Ile Tyr 
625                 630                 635                 640 


Lys Cys Asp Ala Val Leu Cys Thr Leu Pro Leu Gly Val Leu Lys Gln 
                645                 650                 655     


Gln Pro Pro Ala Val Gln Phe Val Pro Pro Leu Pro Glu Trp Lys Thr 
            660                 665                 670         


Ser Ala Val Gln Arg Met Gly Phe Gly Asn Leu Asn Lys Val Val Leu 
        675                 680                 685             


Cys Phe Asp Arg Val Phe Trp Asp Pro Ser Val Asn Leu Phe Gly His 
    690                 695                 700                 


Val Gly Ser Thr Thr Ala Ser Arg Gly Glu Leu Phe Leu Phe Trp Asn 
705                 710                 715                 720 


Leu Tyr Lys Ala Pro Ile Leu Leu Ala Leu Val Ala Gly Glu Ala Ala 
                725                 730                 735     


Gly Ile Met Glu Asn Ile Ser Asp Asp Val Ile Val Gly Arg Cys Leu 
            740                 745                 750         


Ala Ile Leu Lys Gly Ile Phe Gly Ser Ser Ala Val Pro Gln Pro Lys 
        755                 760                 765             


Glu Thr Val Val Ser Arg Trp Arg Ala Asp Pro Trp Ala Arg Gly Ser 
    770                 775                 780                 


Tyr Ser Tyr Val Ala Ala Gly Ser Ser Gly Asn Asp Tyr Asp Leu Met 
785                 790                 795                 800 


Ala Gln Pro Ile Thr Pro Gly Pro Ser Ile Pro Gly Ala Pro Gln Pro 
                805                 810                 815     


Ile Pro Arg Leu Phe Phe Ala Gly Glu His Thr Ile Arg Asn Tyr Pro 
            820                 825                 830         


Ala Thr Val His Gly Ala Leu Leu Ser Gly Leu Arg Glu Ala Gly Arg 
        835                 840                 845             


Ile Ala Asp Gln Phe Leu Gly Ala Met Tyr Thr Leu Pro Arg Gln Ala 
    850                 855                 860                 


Thr Pro Gly Val Pro Ala Gln Gln Ser Pro Ser Met 
865                 870                 875     


<210>  31
<211>  852
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu 
            20                  25                  30          


Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala 
        35                  40                  45              


Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu 
    50                  55                  60                  


Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro 
                85                  90                  95      


Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg 
            100                 105                 110         


Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala 
        115                 120                 125             


Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro 
145                 150                 155                 160 


Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Val Glu Gly 
                165                 170                 175     


Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met Thr Ser Gln Glu 
            180                 185                 190         


Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln Gln Thr Gln Lys 
        195                 200                 205             


Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu Trp Leu Asp Asn 
    210                 215                 220                 


Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln Gln Leu Glu Ala 
225                 230                 235                 240 


Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val His Ser Tyr Leu 
                245                 250                 255     


Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys Arg Ile Lys Pro 
            260                 265                 270         


Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile Gly Ser Gly Val 
        275                 280                 285             


Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe Gly Met Asp Val 
    290                 295                 300                 


Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Val Ala Thr Phe 
305                 310                 315                 320 


Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met Val Val Thr Gly 
                325                 330                 335     


Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln Val Asn Met Glu 
            340                 345                 350         


Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu Ala Asn Gly Gln 
        355                 360                 365             


Ala Val Pro Lys Glu Lys Asp Glu Met Val Glu Gln Glu Phe Asn Arg 
    370                 375                 380                 


Leu Leu Glu Ala Thr Ser Tyr Leu Ser His Gln Leu Asp Phe Asn Val 
385                 390                 395                 400 


Leu Asn Asn Lys Pro Val Ser Leu Gly Gln Ala Leu Glu Val Val Ile 
                405                 410                 415     


Gln Leu Gln Glu Lys His Val Lys Asp Glu Gln Ile Glu His Trp Lys 
            420                 425                 430         


Lys Ile Val Lys Thr Gln Glu Glu Leu Lys Glu Leu Leu Asn Lys Met 
        435                 440                 445             


Val Asn Leu Lys Glu Lys Ile Lys Glu Leu His Gln Gln Tyr Lys Glu 
    450                 455                 460                 


Ala Ser Glu Val Lys Pro Pro Arg Asp Ile Thr Ala Glu Phe Leu Val 
465                 470                 475                 480 


Lys Ser Lys His Arg Asp Leu Thr Ala Leu Cys Lys Glu Tyr Asp Glu 
                485                 490                 495     


Leu Ala Glu Thr Gln Gly Lys Leu Glu Glu Lys Leu Gln Glu Leu Glu 
            500                 505                 510         


Ala Asn Pro Pro Ser Asp Val Tyr Leu Ser Ser Arg Asp Arg Gln Ile 
        515                 520                 525             


Leu Asp Trp His Phe Ala Asn Leu Glu Phe Ala Asn Ala Thr Pro Leu 
    530                 535                 540                 


Ser Thr Leu Ser Leu Lys His Trp Asp Gln Asp Asp Asp Phe Glu Phe 
545                 550                 555                 560 


Thr Gly Ser His Leu Thr Val Arg Asn Gly Tyr Ser Cys Val Pro Val 
                565                 570                 575     


Ala Leu Ala Glu Gly Leu Asp Ile Lys Leu Asn Thr Ala Val Arg Gln 
            580                 585                 590         


Val Arg Tyr Thr Ala Ser Gly Cys Glu Val Ile Ala Val Asn Thr Arg 
        595                 600                 605             


Ser Thr Ser Gln Thr Phe Ile Tyr Lys Cys Asp Ala Val Leu Cys Thr 
    610                 615                 620                 


Leu Pro Leu Gly Val Leu Lys Gln Gln Pro Pro Ala Val Gln Phe Val 
625                 630                 635                 640 


Pro Pro Leu Pro Glu Trp Lys Thr Ser Ala Val Gln Arg Met Gly Phe 
                645                 650                 655     


Gly Asn Leu Asn Lys Val Val Leu Cys Phe Asp Arg Val Phe Trp Asp 
            660                 665                 670         


Pro Ser Val Asn Leu Phe Gly His Val Gly Ser Thr Thr Ala Ser Arg 
        675                 680                 685             


Gly Glu Leu Phe Leu Phe Trp Asn Leu Tyr Lys Ala Pro Ile Leu Leu 
    690                 695                 700                 


Ala Leu Val Ala Gly Glu Ala Ala Gly Ile Met Glu Asn Ile Ser Asp 
705                 710                 715                 720 


Asp Val Ile Val Gly Arg Cys Leu Ala Ile Leu Lys Gly Ile Phe Gly 
                725                 730                 735     


Ser Ser Ala Val Pro Gln Pro Lys Glu Thr Val Val Ser Arg Trp Arg 
            740                 745                 750         


Ala Asp Pro Trp Ala Arg Gly Ser Tyr Ser Tyr Val Ala Ala Gly Ser 
        755                 760                 765             


Ser Gly Asn Asp Tyr Asp Leu Met Ala Gln Pro Ile Thr Pro Gly Pro 
    770                 775                 780                 


Ser Ile Pro Gly Ala Pro Gln Pro Ile Pro Arg Leu Phe Phe Ala Gly 
785                 790                 795                 800 


Glu His Thr Ile Arg Asn Tyr Pro Ala Thr Val His Gly Ala Leu Leu 
                805                 810                 815     


Ser Gly Leu Arg Glu Ala Gly Arg Ile Ala Asp Gln Phe Leu Gly Ala 
            820                 825                 830         


Met Tyr Thr Leu Pro Arg Gln Ala Thr Pro Gly Val Pro Ala Gln Gln 
        835                 840                 845             


Ser Pro Ser Met 
    850         


<210>  32
<211>  817
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu 
1               5                   10                  15      


Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala 
            20                  25                  30          


Leu Asp Ala Val Lys Lys Gly Leu Pro His Ala Pro Ala Leu Ile Lys 
        35                  40                  45              


Arg Thr Asn Arg Arg Ile Pro Glu Arg Thr Ser His Arg Val Ala Asp 
    50                  55                  60                  


His Ala Gln Val Val Arg Val Leu Gly Phe Phe Gln Cys His Ser His 
65                  70                  75                  80  


Pro Ala Gln Ala Phe Asp Asp Ala Met Thr Gln Phe Gly Met Ser Gly 
                85                  90                  95      


Gly Gly Ser Leu Pro Thr Cys Ser Cys Leu Asp Arg Val Ile Gln Lys 
            100                 105                 110         


Asp Lys Gly Pro Tyr Tyr Thr His Leu Gly Ala Gly Pro Ser Val Ala 
        115                 120                 125             


Ala Val Arg Glu Ile Met Glu Asn Arg Tyr Gly Gln Lys Gly Asn Ala 
    130                 135                 140                 


Ile Arg Ile Glu Ile Val Val Tyr Thr Gly Lys Glu Gly Lys Ser Ser 
145                 150                 155                 160 


His Gly Cys Pro Ile Ala Lys Trp Val Leu Arg Arg Ser Ser Asp Glu 
                165                 170                 175     


Glu Lys Val Leu Cys Leu Val Arg Gln Arg Thr Gly His His Cys Pro 
            180                 185                 190         


Thr Ala Val Met Val Val Leu Ile Met Val Trp Asp Gly Ile Pro Leu 
        195                 200                 205             


Pro Met Ala Asp Arg Leu Tyr Thr Glu Leu Thr Glu Asn Leu Lys Ser 
    210                 215                 220                 


Tyr Asn Gly His Pro Thr Asp Arg Arg Cys Thr Leu Asn Glu Asn Arg 
225                 230                 235                 240 


Thr Cys Thr Cys Gln Gly Ile Asp Pro Glu Thr Cys Gly Ala Ser Phe 
                245                 250                 255     


Ser Phe Gly Cys Ser Trp Ser Met Tyr Phe Asn Gly Cys Lys Phe Gly 
            260                 265                 270         


Arg Ser Pro Ser Pro Arg Arg Phe Arg Ile Asp Pro Ser Ser Pro Leu 
        275                 280                 285             


His Glu Lys Asn Leu Glu Asp Asn Leu Gln Ser Leu Ala Thr Arg Leu 
    290                 295                 300                 


Ala Pro Ile Tyr Lys Gln Tyr Ala Pro Val Ala Tyr Gln Asn Gln Val 
305                 310                 315                 320 


Glu Tyr Glu Asn Val Ala Arg Glu Cys Arg Leu Gly Ser Lys Glu Gly 
                325                 330                 335     


Arg Pro Phe Ser Gly Val Thr Ala Cys Leu Asp Phe Cys Ala His Pro 
            340                 345                 350         


His Arg Asp Ile His Asn Met Asn Asn Gly Ser Thr Val Val Cys Thr 
        355                 360                 365             


Leu Thr Arg Glu Asp Asn Arg Ser Leu Gly Val Ile Pro Gln Asp Glu 
    370                 375                 380                 


Gln Leu His Val Leu Pro Leu Tyr Lys Leu Ser Asp Thr Asp Glu Phe 
385                 390                 395                 400 


Gly Ser Lys Glu Gly Met Glu Ala Lys Ile Lys Ser Gly Ala Ile Glu 
                405                 410                 415     


Val Leu Ala Pro Arg Arg Lys Lys Arg Thr Cys Phe Thr Gln Pro Val 
            420                 425                 430         


Pro Arg Ser Gly Lys Lys Arg Ala Ala Met Met Thr Glu Val Leu Ala 
        435                 440                 445             


His Lys Ile Arg Ala Val Glu Lys Lys Pro Ile Pro Arg Ile Lys Arg 
    450                 455                 460                 


Lys Asn Asn Ser Thr Thr Thr Asn Asn Ser Lys Pro Ser Ser Leu Pro 
465                 470                 475                 480 


Thr Leu Gly Ser Asn Thr Glu Thr Val Gln Pro Glu Val Lys Ser Glu 
                485                 490                 495     


Thr Glu Pro His Phe Ile Leu Lys Ser Ser Asp Asn Thr Lys Thr Tyr 
            500                 505                 510         


Ser Leu Met Pro Ser Ala Pro His Pro Val Lys Glu Ala Ser Pro Gly 
        515                 520                 525             


Phe Ser Trp Ser Pro Lys Thr Ala Ser Ala Thr Pro Ala Pro Leu Lys 
    530                 535                 540                 


Asn Asp Ala Thr Ala Ser Cys Gly Phe Ser Glu Arg Ser Ser Thr Pro 
545                 550                 555                 560 


His Cys Thr Met Pro Ser Gly Arg Leu Ser Gly Ala Asn Ala Ala Ala 
                565                 570                 575     


Ala Asp Gly Pro Gly Ile Ser Gln Leu Gly Glu Val Ala Pro Leu Pro 
            580                 585                 590         


Thr Leu Ser Ala Pro Val Met Glu Pro Leu Ile Asn Ser Glu Pro Ser 
        595                 600                 605             


Thr Gly Val Thr Glu Pro Leu Thr Pro His Gln Pro Asn His Gln Pro 
    610                 615                 620                 


Ser Phe Leu Thr Ser Pro Gln Asp Leu Ala Ser Ser Pro Met Glu Glu 
625                 630                 635                 640 


Asp Glu Gln His Ser Glu Ala Asp Glu Pro Pro Ser Asp Glu Pro Leu 
                645                 650                 655     


Ser Asp Asp Pro Leu Ser Pro Ala Glu Glu Lys Leu Pro His Ile Asp 
            660                 665                 670         


Glu Tyr Trp Ser Asp Ser Glu His Ile Phe Leu Asp Ala Asn Ile Gly 
        675                 680                 685             


Gly Val Ala Ile Ala Pro Ala His Gly Ser Val Leu Ile Glu Cys Ala 
    690                 695                 700                 


Arg Arg Glu Leu His Ala Thr Thr Pro Val Glu His Pro Asn Arg Asn 
705                 710                 715                 720 


His Pro Thr Arg Leu Ser Leu Val Phe Tyr Gln His Lys Asn Leu Asn 
                725                 730                 735     


Lys Pro Gln His Gly Phe Glu Leu Asn Lys Ile Lys Phe Glu Ala Lys 
            740                 745                 750         


Glu Ala Lys Asn Lys Lys Met Lys Ala Ser Glu Gln Lys Asp Gln Ala 
        755                 760                 765             


Ala Asn Glu Gly Pro Glu Gln Ser Ser Glu Val Asn Glu Leu Asn Gln 
    770                 775                 780                 


Ile Pro Ser His Lys Ala Leu Thr Leu Thr His Asp Asn Val Val Thr 
785                 790                 795                 800 


Val Ser Pro Tyr Ala Leu Thr His Val Ala Gly Pro Tyr Asn His Trp 
                805                 810                 815     


Val 
    


<210>  33
<211>  340
<212>  PRT
<213>  X. laevis

<400>  33

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Ser Arg 
1               5                   10                  15      


Val Val Lys Pro Lys Val Ala Ser Met Glu Glu Met Ala Ala Phe His 
            20                  25                  30          


Thr Asp Ala Tyr Leu Gln His Leu His Lys Val Ser Glu Glu Gly Asp 
        35                  40                  45              


Asn Asp Asp Pro Glu Thr Leu Glu Tyr Gly Leu Gly Tyr Asp Cys Pro 
    50                  55                  60                  


Ile Thr Glu Gly Ile Tyr Asp Tyr Ala Ala Ala Val Gly Gly Ala Thr 
65                  70                  75                  80  


Leu Thr Ala Ala Glu Gln Leu Ile Glu Gly Lys Thr Arg Ile Ala Val 
                85                  90                  95      


Asn Trp Pro Gly Gly Trp His His Ala Lys Lys Asp Glu Ala Ser Gly 
            100                 105                 110         


Phe Cys Tyr Leu Asn Asp Ala Val Leu Gly Ile Leu Lys Leu Arg Glu 
        115                 120                 125             


Lys Phe Asp Arg Val Leu Tyr Val Asp Met Asp Leu His His Gly Asp 
    130                 135                 140                 


Gly Val Glu Asp Ala Phe Ser Phe Thr Ser Lys Val Met Thr Val Ser 
145                 150                 155                 160 


Leu His Lys Phe Ser Pro Gly Phe Phe Pro Gly Thr Gly Asp Val Ser 
                165                 170                 175     


Asp Ile Gly Leu Gly Lys Gly Arg Tyr Tyr Ser Ile Asn Val Pro Leu 
            180                 185                 190         


Gln Asp Gly Ile Gln Asp Asp Lys Tyr Tyr Gln Ile Cys Glu Gly Val 
        195                 200                 205             


Leu Lys Glu Val Phe Thr Thr Phe Asn Pro Glu Ala Val Val Leu Gln 
    210                 215                 220                 


Leu Gly Ala Asp Thr Ile Ala Gly Asp Pro Met Cys Ser Phe Asn Met 
225                 230                 235                 240 


Thr Pro Glu Gly Ile Gly Lys Cys Leu Lys Tyr Val Leu Gln Trp Gln 
                245                 250                 255     


Leu Pro Thr Leu Ile Leu Gly Gly Gly Gly Tyr His Leu Pro Asn Thr 
            260                 265                 270         


Ala Arg Cys Trp Thr Tyr Leu Thr Ala Leu Ile Val Gly Arg Thr Leu 
        275                 280                 285             


Ser Ser Glu Ile Pro Asp His Glu Phe Phe Thr Glu Tyr Gly Pro Asp 
    290                 295                 300                 


Tyr Val Leu Glu Ile Thr Pro Ser Cys Arg Pro Asp Arg Asn Asp Thr 
305                 310                 315                 320 


Gln Lys Val Gln Glu Ile Leu Gln Ser Ile Lys Gly Asn Leu Lys Arg 
                325                 330                 335     


Val Val Glu Phe 
            340 


<210>  34
<211>  337
<212>  PRT
<213>  S. cerevisiae

<400>  34

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Arg Arg Val 
1               5                   10                  15      


Ala Tyr Phe Tyr Asp Ala Asp Val Gly Asn Tyr Ala Tyr Gly Ala Gly 
            20                  25                  30          


His Pro Met Lys Pro His Arg Ile Arg Met Ala His Ser Leu Ile Met 
        35                  40                  45              


Asn Tyr Gly Leu Tyr Lys Lys Met Glu Ile Tyr Arg Ala Lys Pro Ala 
    50                  55                  60                  


Thr Lys Gln Glu Met Cys Gln Phe His Thr Asp Glu Tyr Ile Asp Phe 
65                  70                  75                  80  


Leu Ser Arg Val Thr Pro Asp Asn Leu Glu Met Phe Lys Arg Glu Ser 
                85                  90                  95      


Val Lys Phe Asn Val Gly Asp Asp Cys Pro Val Phe Asp Gly Leu Tyr 
            100                 105                 110         


Glu Tyr Cys Ser Ile Ser Gly Gly Gly Ser Met Glu Gly Ala Ala Arg 
        115                 120                 125             


Leu Asn Arg Gly Lys Cys Asp Val Ala Val Asn Tyr Ala Gly Gly Leu 
    130                 135                 140                 


His His Ala Lys Lys Ser Glu Ala Ser Gly Phe Cys Tyr Leu Asn Asp 
145                 150                 155                 160 


Ile Val Leu Gly Ile Ile Glu Leu Leu Arg Tyr His Pro Arg Val Leu 
                165                 170                 175     


Tyr Ile Asp Ile Asp Val His His Gly Asp Gly Val Glu Glu Ala Phe 
            180                 185                 190         


Tyr Thr Thr Asp Arg Val Met Thr Cys Ser Phe His Lys Tyr Gly Glu 
        195                 200                 205             


Phe Phe Pro Gly Thr Gly Glu Leu Arg Asp Ile Gly Val Gly Ala Gly 
    210                 215                 220                 


Lys Asn Tyr Ala Val Asn Val Pro Leu Arg Asp Gly Ile Asp Asp Ala 
225                 230                 235                 240 


Thr Tyr Arg Ser Val Phe Glu Pro Val Ile Lys Lys Ile Met Glu Trp 
                245                 250                 255     


Tyr Gln Pro Ser Ala Val Val Leu Gln Cys Gly Gly Asp Ser Leu Ser 
            260                 265                 270         


Gly Asp Arg Leu Gly Cys Phe Asn Leu Ser Met Glu Gly His Ala Asn 
        275                 280                 285             


Cys Val Asn Tyr Val Lys Ser Phe Gly Ile Pro Met Met Val Val Gly 
    290                 295                 300                 


Gly Gly Gly Tyr Thr Met Arg Asn Val Ala Arg Thr Trp Cys Phe Glu 
305                 310                 315                 320 


Thr Gly Leu Leu Asn Asn Val Val Leu Asp Lys Asp Leu Pro Tyr Glu 
                325                 330                 335     


Phe 
    


<210>  35
<211>  315
<212>  PRT
<213>  M. loti

<400>  35

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Pro Leu 
1               5                   10                  15      


Gln Ile Val His His Pro Asp Tyr Asp Ala Gly Phe Ala Thr Asn His 
            20                  25                  30          


Arg Phe Pro Met Ser Lys Tyr Pro Leu Leu Met Glu Ala Leu Arg Ala 
        35                  40                  45              


Arg Gly Leu Ala Ser Pro Asp Ala Leu Asn Thr Thr Glu Pro Ala Pro 
    50                  55                  60                  


Ala Ser Trp Leu Lys Leu Ala His Ala Ala Asp Tyr Val Asp Gln Val 
65                  70                  75                  80  


Ile Ser Cys Ser Val Pro Glu Lys Ile Glu Arg Glu Ile Gly Phe Pro 
                85                  90                  95      


Val Gly Pro Arg Val Ser Leu Arg Ala Gln Leu Ala Thr Gly Gly Thr 
            100                 105                 110         


Ile Leu Ala Ala Arg Leu Ala Leu Arg His Gly Ile Ala Cys Asn Thr 
        115                 120                 125             


Ala Gly Gly Ser His His Ala Arg Arg Ala Gln Gly Ala Gly Phe Cys 
    130                 135                 140                 


Thr Phe Asn Asp Val Ala Val Ala Ser Leu Val Leu Leu Asp Glu Gly 
145                 150                 155                 160 


Ala Ala Gln Asn Ile Leu Val Val Asp Leu Asp Val His Gln Gly Asp 
                165                 170                 175     


Gly Thr Ala Asp Ile Leu Ser Asp Glu Pro Gly Val Phe Thr Phe Ser 
            180                 185                 190         


Met His Gly Glu Arg Asn Tyr Pro Val Arg Lys Ile Ala Ser Asp Leu 
        195                 200                 205             


Asp Ile Ala Leu Pro Asp Gly Thr Gly Asp Ala Ala Tyr Leu Arg Arg 
    210                 215                 220                 


Leu Ala Thr Ile Leu Pro Glu Leu Ser Ala Arg Ala Arg Trp Asp Ile 
225                 230                 235                 240 


Val Phe Tyr Asn Ala Gly Val Asp Val His Ala Glu Asp Arg Leu Gly 
                245                 250                 255     


Arg Leu Ala Leu Ser Asn Gly Gly Leu Arg Ala Arg Asp Glu Met Val 
            260                 265                 270         


Ile Gly His Phe Arg Ala Leu Gly Ile Pro Val Cys Gly Val Ile Gly 
        275                 280                 285             


Gly Gly Tyr Ser Thr Asp Val Pro Ala Leu Ala Ser Arg His Ala Ile 
    290                 295                 300                 


Leu Phe Glu Val Ala Ser Thr Tyr Ala Glu Phe 
305                 310                 315 


<210>  36
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  36

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Leu His 
1               5                   10                  15      


Thr Thr Gln Leu Tyr Gln His Val Pro Glu Thr Arg Trp Pro Ile Val 
            20                  25                  30          


Tyr Ser Pro Arg Tyr Asn Ile Thr Phe Met Gly Leu Glu Lys Leu His 
        35                  40                  45              


Pro Phe Asp Ala Gly Lys Trp Gly Lys Val Ile Asn Phe Leu Lys Glu 
    50                  55                  60                  


Glu Lys Leu Leu Ser Asp Ser Met Leu Val Glu Ala Arg Glu Ala Ser 
65                  70                  75                  80  


Glu Glu Asp Leu Leu Val Val His Thr Arg Arg Tyr Leu Asn Glu Leu 
                85                  90                  95      


Lys Trp Ser Phe Ala Val Ala Thr Ile Thr Glu Ile Pro Pro Val Ile 
            100                 105                 110         


Phe Leu Pro Asn Phe Leu Val Gln Arg Lys Val Leu Arg Pro Leu Arg 
        115                 120                 125             


Thr Gln Thr Gly Gly Thr Ile Met Ala Gly Lys Leu Ala Val Glu Arg 
    130                 135                 140                 


Gly Trp Ala Ile Asn Val Gly Gly Gly Phe His His Cys Ser Ser Asp 
145                 150                 155                 160 


Arg Gly Gly Gly Phe Cys Ala Tyr Ala Asp Ile Thr Leu Ala Ile Lys 
                165                 170                 175     


Phe Leu Phe Glu Arg Val Glu Gly Ile Ser Arg Ala Thr Ile Ile Asp 
            180                 185                 190         


Leu Asp Ala His Gln Gly Asn Gly His Glu Arg Asp Phe Met Asp Asp 
        195                 200                 205             


Lys Arg Val Tyr Ile Met Asp Val Tyr Asn Arg His Ile Tyr Pro Gly 
    210                 215                 220                 


Asp Arg Phe Ala Lys Gln Ala Ile Arg Arg Lys Val Glu Leu Glu Trp 
225                 230                 235                 240 


Gly Thr Glu Asp Asp Glu Tyr Leu Asp Lys Val Glu Arg Asn Ile Lys 
                245                 250                 255     


Lys Ser Leu Gln Glu His Leu Pro Asp Val Val Val Tyr Asn Ala Gly 
            260                 265                 270         


Thr Asp Ile Leu Glu Gly Asp Arg Leu Gly Gly Leu Ser Ile Ser Pro 
        275                 280                 285             


Ala Gly Ile Val Lys Arg Asp Glu Leu Val Phe Arg Met Val Arg Gly 
    290                 295                 300                 


Arg Arg Val Pro Ile Leu Met Val Thr Ser Gly Gly Tyr Gln Lys Arg 
305                 310                 315                 320 


Thr Ala Arg Ile Ile Ala Asp Ser Ile Leu Asn Leu Phe Gly Leu Gly 
                325                 330                 335     


Leu Ile Gly Pro Glu Ser Pro Ser Val Ser Ala Gln Asn Ser Asp Thr 
            340                 345                 350         


Pro Leu Leu Pro Pro Ala Val Pro Glu Phe 
        355                 360         


<210>  37
<211>  226
<212>  PRT
<213>  A. thaliana

<400>  37

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Glu Phe 
1               5                   10                  15      


Trp Gly Ile Glu Val Lys Ser Gly Lys Pro Val Thr Val Thr Pro Glu 
            20                  25                  30          


Glu Gly Ile Leu Ile His Val Ser Gln Ala Ser Leu Gly Glu Cys Lys 
        35                  40                  45              


Asn Lys Lys Gly Glu Phe Val Pro Leu His Val Lys Val Gly Asn Gln 
    50                  55                  60                  


Asn Leu Val Leu Gly Thr Leu Ser Thr Glu Asn Ile Pro Gln Leu Phe 
65                  70                  75                  80  


Cys Asp Leu Val Phe Asp Lys Glu Phe Glu Leu Ser His Thr Trp Gly 
                85                  90                  95      


Lys Gly Ser Val Tyr Phe Val Gly Tyr Lys Thr Pro Asn Ile Glu Pro 
            100                 105                 110         


Gln Gly Tyr Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Val Pro Ala 
        115                 120                 125             


Gly Asn Ala Ala Lys Ala Val Ala Lys Pro Lys Ala Lys Pro Ala Glu 
    130                 135                 140                 


Val Lys Pro Ala Val Asp Asp Glu Glu Asp Glu Ser Asp Ser Asp Gly 
145                 150                 155                 160 


Met Asp Glu Asp Asp Ser Asp Gly Glu Asp Ser Glu Glu Glu Glu Pro 
                165                 170                 175     


Thr Pro Lys Lys Pro Ala Ser Ser Lys Lys Arg Ala Asn Glu Thr Thr 
            180                 185                 190         


Pro Lys Ala Pro Val Ser Ala Lys Lys Ala Lys Val Ala Val Thr Pro 
        195                 200                 205             


Gln Lys Thr Asp Glu Lys Lys Lys Gly Gly Lys Ala Ala Asn Gln Ser 
    210                 215                 220                 


Glu Phe 
225     


<210>  38
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  38

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Val Gly 
1               5                   10                  15      


Ala Gly Ile Ser Thr Pro Ser Gly Ile Pro Asp Phe Arg Ser Pro Gly 
            20                  25                  30          


Ser Gly Leu Tyr Ser Asn Leu Gln Gln Tyr Asp Leu Pro Tyr Pro Glu 
        35                  40                  45              


Ala Ile Phe Glu Leu Pro Phe Phe Phe His Asn Pro Lys Pro Phe Phe 
    50                  55                  60                  


Thr Leu Ala Lys Glu Leu Tyr Pro Gly Asn Tyr Lys Pro Asn Val Thr 
65                  70                  75                  80  


His Tyr Phe Leu Arg Leu Leu His Asp Lys Gly Leu Leu Leu Arg Leu 
                85                  90                  95      


Tyr Thr Gln Asn Ile Asp Gly Leu Glu Arg Val Ser Gly Ile Pro Ala 
            100                 105                 110         


Ser Lys Leu Val Glu Ala His Gly Thr Phe Ala Ser Ala Thr Cys Thr 
        115                 120                 125             


Val Cys Gln Arg Pro Phe Pro Gly Glu Asp Ile Arg Ala Asp Val Met 
    130                 135                 140                 


Ala Asp Arg Val Pro Arg Cys Pro Val Cys Thr Gly Val Val Lys Pro 
145                 150                 155                 160 


Asp Ile Val Phe Phe Gly Glu Pro Leu Pro Gln Arg Phe Leu Leu His 
                165                 170                 175     


Val Val Asp Phe Pro Met Ala Asp Leu Leu Leu Ile Leu Gly Thr Ser 
            180                 185                 190         


Leu Glu Val Glu Pro Phe Ala Ser Leu Thr Glu Ala Val Arg Ser Ser 
        195                 200                 205             


Val Pro Arg Leu Leu Ile Asn Arg Asp Leu Val Gly Pro Leu Ala Trp 
    210                 215                 220                 


His Pro Arg Ser Arg Asp Val Ala Gln Leu Gly Asp Val Val His Gly 
225                 230                 235                 240 


Val Glu Ser Leu Val Glu Leu Leu Gly Trp Thr Glu Glu Met Arg Asp 
                245                 250                 255     


Leu Val Gln Arg Glu Thr Gly Lys Leu Asp Gly Pro Asp Lys Glu Phe 
            260                 265                 270         


<210>  39
<211>  306
<212>  PRT
<213>  S. cerevisiae

<400>  39

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Thr Glu Met 
1               5                   10                  15      


Ser Val Arg Lys Ile Ala Ala His Met Lys Ser Asn Pro Asn Ala Lys 
            20                  25                  30          


Val Ile Phe Met Val Gly Ala Gly Ile Ser Thr Ser Cys Gly Ile Pro 
        35                  40                  45              


Asp Phe Arg Ser Pro Gly Thr Gly Leu Tyr His Asn Leu Ala Arg Leu 
    50                  55                  60                  


Lys Leu Pro Tyr Pro Glu Ala Val Phe Asp Val Asp Phe Phe Gln Ser 
65                  70                  75                  80  


Asp Pro Leu Pro Phe Tyr Thr Leu Ala Lys Glu Leu Tyr Pro Gly Asn 
                85                  90                  95      


Phe Arg Pro Ser Lys Phe His Tyr Leu Leu Lys Leu Phe Gln Asp Lys 
            100                 105                 110         


Asp Val Leu Lys Arg Val Tyr Thr Gln Asn Ile Asp Thr Leu Glu Arg 
        115                 120                 125             


Gln Ala Gly Val Lys Asp Asp Leu Ile Ile Glu Ala His Gly Ser Phe 
    130                 135                 140                 


Ala His Cys His Cys Ile Gly Cys Gly Lys Val Tyr Pro Pro Gln Val 
145                 150                 155                 160 


Phe Lys Ser Lys Leu Ala Glu His Pro Ile Lys Asp Phe Val Lys Cys 
                165                 170                 175     


Asp Val Cys Gly Glu Leu Val Lys Pro Ala Ile Val Phe Phe Gly Glu 
            180                 185                 190         


Asp Leu Pro Asp Ser Phe Ser Glu Thr Trp Leu Asn Asp Ser Glu Trp 
        195                 200                 205             


Leu Arg Glu Lys Ile Thr Thr Ser Gly Lys His Pro Gln Gln Pro Leu 
    210                 215                 220                 


Val Ile Val Val Gly Thr Ser Leu Ala Val Tyr Pro Phe Ala Ser Leu 
225                 230                 235                 240 


Pro Glu Glu Ile Pro Arg Lys Val Lys Arg Val Leu Cys Asn Leu Glu 
                245                 250                 255     


Thr Val Gly Asp Phe Lys Ala Asn Lys Arg Pro Thr Asp Leu Ile Val 
            260                 265                 270         


His Gln Tyr Ser Asp Glu Phe Ala Glu Gln Leu Val Glu Glu Leu Gly 
        275                 280                 285             


Trp Gln Glu Asp Phe Glu Lys Ile Leu Thr Ala Gln Gly Gly Met Gly 
    290                 295                 300                 


Glu Phe 
305     


<210>  40
<211>  257
<212>  PRT
<213>  E. coli

<400>  40

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Glu Lys 
1               5                   10                  15      


Pro Arg Val Leu Val Leu Thr Gly Ala Gly Ile Ser Ala Glu Ser Gly 
            20                  25                  30          


Ile Arg Thr Phe Arg Ala Ala Asp Gly Leu Trp Glu Glu His Arg Val 
        35                  40                  45              


Glu Asp Val Ala Thr Pro Glu Gly Phe Asp Arg Asp Pro Glu Leu Val 
    50                  55                  60                  


Gln Ala Phe Tyr Asn Ala Arg Arg Arg Gln Leu Gln Gln Pro Glu Ile 
65                  70                  75                  80  


Gln Pro Asn Ala Ala His Leu Ala Leu Ala Lys Leu Gln Asp Ala Leu 
                85                  90                  95      


Gly Asp Arg Phe Leu Leu Val Thr Gln Asn Ile Asp Asn Leu His Glu 
            100                 105                 110         


Arg Ala Gly Asn Thr Asn Val Ile His Met His Gly Glu Leu Leu Lys 
        115                 120                 125             


Val Arg Cys Ser Gln Ser Gly Gln Val Leu Asp Trp Thr Gly Asp Val 
    130                 135                 140                 


Thr Pro Glu Asp Lys Cys His Cys Cys Gln Phe Pro Ala Pro Leu Arg 
145                 150                 155                 160 


Pro His Val Val Trp Phe Gly Glu Met Pro Leu Gly Met Asp Glu Ile 
                165                 170                 175     


Tyr Met Ala Leu Ser Met Ala Asp Ile Phe Ile Ala Ile Gly Thr Ser 
            180                 185                 190         


Gly His Val Tyr Pro Ala Ala Gly Phe Val His Glu Ala Lys Leu His 
        195                 200                 205             


Gly Ala His Thr Val Glu Leu Asn Leu Glu Pro Ser Gln Val Gly Asn 
    210                 215                 220                 


Glu Phe Ala Glu Lys Tyr Tyr Gly Pro Ala Ser Gln Val Val Pro Glu 
225                 230                 235                 240 


Phe Val Glu Lys Leu Leu Lys Gly Leu Lys Ala Gly Ser Ile Ala Glu 
                245                 250                 255     


Phe 
    


<210>  41
<211>  346
<212>  PRT
<213>  C. albicans

<400>  41

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Pro Ser 
1               5                   10                  15      


Leu Asp Asp Ile Leu Lys Pro Val Ala Glu Ala Val Lys Asn Gly Lys 
            20                  25                  30          


Lys Val Thr Phe Phe Asn Gly Ala Gly Ile Ser Thr Gly Ala Gly Ile 
        35                  40                  45              


Pro Asp Phe Arg Ser Pro Asp Thr Gly Leu Tyr Ala Asn Leu Ala Lys 
    50                  55                  60                  


Leu Asn Leu Pro Phe Ala Glu Ala Val Phe Asp Ile Asp Phe Phe Lys 
65                  70                  75                  80  


Glu Asp Pro Lys Pro Phe Tyr Thr Leu Ala Glu Glu Leu Tyr Pro Gly 
                85                  90                  95      


Asn Phe Ala Pro Thr Lys Phe His His Phe Ile Lys Leu Leu Gln Asp 
            100                 105                 110         


Gln Gly Ser Leu Lys Arg Val Tyr Thr Gln Asn Ile Asp Thr Leu Glu 
        115                 120                 125             


Arg Leu Ala Gly Val Glu Asp Lys Tyr Ile Val Glu Ala His Gly Ser 
    130                 135                 140                 


Phe Ala Ser Asn His Cys Val Asp Cys His Lys Glu Met Thr Thr Glu 
145                 150                 155                 160 


Thr Leu Lys Thr Tyr Met Lys Asp Lys Lys Ile Pro Ser Cys Gln His 
                165                 170                 175     


Cys Glu Gly Tyr Val Lys Pro Asp Ile Val Phe Phe Gly Glu Gly Leu 
            180                 185                 190         


Pro Val Lys Phe Phe Asp Leu Trp Glu Asp Asp Cys Glu Asp Val Glu 
        195                 200                 205             


Val Ala Ile Val Ala Gly Thr Ser Leu Thr Val Phe Pro Phe Ala Ser 
    210                 215                 220                 


Leu Pro Gly Glu Val Asn Lys Lys Cys Leu Arg Val Leu Val Asn Lys 
225                 230                 235                 240 


Glu Lys Val Gly Thr Phe Lys His Glu Pro Arg Lys Ser Asp Ile Ile 
                245                 250                 255     


Ala Leu His Asp Cys Asp Ile Val Ala Glu Arg Leu Cys Thr Leu Leu 
            260                 265                 270         


Gly Leu Asp Asp Lys Leu Asn Glu Val Tyr Glu Lys Glu Lys Ile Lys 
        275                 280                 285             


Tyr Ser Lys Ala Glu Thr Lys Glu Ile Lys Met His Glu Ile Glu Asp 
    290                 295                 300                 


Lys Leu Lys Glu Glu Ala His Leu Lys Glu Asp Lys His Thr Thr Lys 
305                 310                 315                 320 


Val Asp Lys Lys Glu Lys Gln Asn Asp Ala Asn Asp Lys Glu Leu Glu 
                325                 330                 335     


Gln Leu Ile Asp Lys Ala Lys Ala Glu Phe 
            340                 345     


<210>  42
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  42

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Ser Ser Ser 
1               5                   10                  15      


Met Ala Asp Phe Arg Lys Phe Phe Ala Lys Ala Lys His Ile Val Ile 
            20                  25                  30          


Ile Ser Gly Ala Gly Val Ser Ala Glu Ser Gly Val Pro Thr Phe Arg 
        35                  40                  45              


Gly Ala Gly Gly Tyr Trp Arg Lys Trp Gln Ala Gln Asp Leu Ala Thr 
    50                  55                  60                  


Pro Leu Ala Phe Ala His Asn Pro Ser Arg Val Trp Glu Phe Tyr His 
65                  70                  75                  80  


Tyr Arg Arg Glu Val Met Gly Ser Lys Glu Pro Asn Ala Gly His Arg 
                85                  90                  95      


Ala Ile Ala Glu Cys Glu Thr Arg Leu Gly Lys Gln Gly Arg Arg Val 
            100                 105                 110         


Val Val Ile Thr Gln Asn Ile Asp Glu Leu His Arg Lys Ala Gly Thr 
        115                 120                 125             


Lys Asn Leu Leu Glu Ile His Gly Ser Leu Phe Lys Thr Arg Cys Thr 
    130                 135                 140                 


Ser Cys Gly Val Val Ala Glu Asn Tyr Lys Ser Pro Ile Cys Pro Ala 
145                 150                 155                 160 


Leu Ser Gly Lys Gly Ala Pro Glu Pro Gly Thr Gln Asp Ala Ser Ile 
                165                 170                 175     


Pro Val Glu Lys Leu Pro Arg Cys Glu Glu Ala Gly Cys Gly Gly Leu 
            180                 185                 190         


Leu Arg Pro His Val Val Trp Phe Gly Glu Asn Leu Asp Pro Ala Ile 
        195                 200                 205             


Leu Glu Glu Val Asp Arg Glu Leu Ala His Cys Asp Leu Cys Leu Val 
    210                 215                 220                 


Val Gly Thr Ser Ser Val Val Tyr Pro Ala Ala Met Phe Ala Pro Gln 
225                 230                 235                 240 


Val Ala Ala Arg Gly Val Pro Val Ala Glu Phe Asn Thr Glu Thr Thr 
                245                 250                 255     


Pro Ala Thr Asn Arg Phe Arg Phe His Phe Gln Gly Pro Cys Gly Thr 
            260                 265                 270         


Thr Leu Pro Glu Ala Leu Ala Cys His Glu Asn Glu Thr Val Ser Glu 
        275                 280                 285             


Phe 
    


<210>  43
<211>  288
<212>  PRT
<213>  P. falciparum

<400>  43

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Gly Asn 
1               5                   10                  15      


Leu Met Ile Ser Phe Leu Lys Lys Asp Thr Gln Ser Ile Thr Leu Glu 
            20                  25                  30          


Glu Leu Ala Lys Ile Ile Lys Lys Cys Lys His Val Val Ala Leu Thr 
        35                  40                  45              


Gly Ser Gly Thr Ser Ala Glu Ser Asn Ile Pro Ser Phe Arg Gly Ser 
    50                  55                  60                  


Ser Asn Ser Ile Trp Ser Lys Tyr Asp Pro Arg Ile Tyr Gly Thr Ile 
65                  70                  75                  80  


Trp Gly Phe Trp Lys Tyr Pro Glu Lys Ile Trp Glu Val Ile Arg Asp 
                85                  90                  95      


Ile Ser Ser Asp Tyr Glu Ile Glu Ile Asn Asn Gly His Val Ala Leu 
            100                 105                 110         


Ser Thr Leu Glu Ser Leu Gly Tyr Leu Lys Ser Val Val Thr Gln Asn 
        115                 120                 125             


Val Asp Gly Leu His Glu Ala Ser Gly Asn Thr Lys Val Ile Ser Leu 
    130                 135                 140                 


His Gly Asn Val Phe Glu Ala Val Cys Cys Thr Cys Asn Lys Ile Val 
145                 150                 155                 160 


Lys Leu Asn Lys Ile Met Leu Gln Lys Thr Ser His Phe Met His Gln 
                165                 170                 175     


Leu Pro Pro Glu Cys Pro Cys Gly Gly Ile Phe Lys Pro Asn Ile Ile 
            180                 185                 190         


Leu Phe Gly Glu Val Val Ser Ser Asp Leu Leu Lys Glu Ala Glu Glu 
        195                 200                 205             


Glu Ile Ala Lys Cys Asp Leu Leu Leu Val Ile Gly Thr Ser Ser Thr 
    210                 215                 220                 


Val Ser Thr Ala Thr Asn Leu Cys His Phe Ala Cys Lys Lys Lys Lys 
225                 230                 235                 240 


Lys Ile Val Glu Ile Asn Ile Ser Lys Thr Tyr Ile Thr Asn Lys Met 
                245                 250                 255     


Ser Asp Tyr His Val Cys Ala Lys Phe Ser Glu Leu Thr Lys Val Ala 
            260                 265                 270         


Asn Ile Leu Lys Gly Ser Ser Glu Lys Asn Lys Lys Ile Met Glu Phe 
        275                 280                 285             


<210>  44
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  44

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Ser Val 
1               5                   10                  15      


Asn Tyr Ala Ala Gly Leu Ser Pro Tyr Ala Asp Lys Gly Lys Cys Gly 
            20                  25                  30          


Leu Pro Glu Ile Phe Asp Pro Pro Glu Glu Leu Glu Arg Lys Val Trp 
        35                  40                  45              


Glu Leu Ala Arg Leu Val Trp Gln Ser Ser Ser Val Val Phe His Thr 
    50                  55                  60                  


Gly Ala Gly Ile Ser Thr Ala Ser Gly Ile Pro Asp Phe Arg Gly Pro 
65                  70                  75                  80  


His Gly Val Trp Thr Met Glu Glu Arg Gly Leu Ala Pro Lys Phe Asp 
                85                  90                  95      


Thr Thr Phe Glu Ser Ala Arg Pro Thr Gln Thr His Met Ala Leu Val 
            100                 105                 110         


Gln Leu Glu Arg Val Gly Leu Leu Arg Phe Leu Val Ser Gln Asn Val 
        115                 120                 125             


Asp Gly Leu His Val Arg Ser Gly Phe Pro Arg Asp Lys Leu Ala Glu 
    130                 135                 140                 


Leu His Gly Asn Met Phe Val Glu Glu Cys Ala Lys Cys Lys Thr Gln 
145                 150                 155                 160 


Tyr Val Arg Asp Thr Val Val Gly Thr Met Gly Leu Lys Ala Thr Gly 
                165                 170                 175     


Arg Leu Cys Thr Val Ala Lys Ala Arg Gly Leu Arg Ala Cys Arg Gly 
            180                 185                 190         


Glu Leu Arg Asp Thr Ile Leu Asp Trp Glu Asp Ser Leu Pro Asp Arg 
        195                 200                 205             


Asp Leu Ala Leu Ala Asp Glu Ala Ser Arg Asn Ala Asp Leu Ser Ile 
    210                 215                 220                 


Thr Leu Gly Thr Ser Leu Gln Ile Arg Pro Ser Gly Asn Leu Pro Leu 
225                 230                 235                 240 


Ala Thr Lys Arg Arg Gly Gly Arg Leu Val Ile Val Asn Leu Gln Pro 
                245                 250                 255     


Thr Lys His Asp Arg His Ala Asp Leu Arg Ile His Gly Tyr Val Asp 
            260                 265                 270         


Glu Val Met Thr Arg Leu Met Lys His Leu Gly Leu Glu Ile Pro Ala 
        275                 280                 285             


Trp Asp Gly Pro Arg Val Leu Glu Arg Ala Leu Pro Pro Leu Glu Phe 
    290                 295                 300                 


<210>  45
<211>  234
<212>  PRT
<213>  C. trachomatis

<400>  45

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Thr Thr 
1               5                   10                  15      


Asn Ser Thr Gln Asp Thr Leu Tyr Leu Ser Leu His Gly Gly Ile Asp 
            20                  25                  30          


Ser Ala Ile Pro Tyr Pro Val Arg Arg Val Glu Gln Leu Leu Gln Phe 
        35                  40                  45              


Ser Phe Leu Pro Glu Leu Gln Phe Gln Asn Ala Ala Val Lys Gln Arg 
    50                  55                  60                  


Ile Gln Arg Leu Cys Tyr Arg Glu Glu Lys Arg Leu Ala Val Ser Ser 
65                  70                  75                  80  


Leu Ala Lys Trp Leu Gly Gln Leu His Lys Gln Arg Leu Arg Ala Pro 
                85                  90                  95      


Lys Asn Pro Pro Val Ala Ile Cys Trp Ile Asn Ser Tyr Val Gly Tyr 
            100                 105                 110         


Gly Val Phe Ala Arg Glu Ser Ile Pro Ala Trp Ser Tyr Ile Gly Glu 
        115                 120                 125             


Tyr Thr Gly Ile Leu Arg Arg Arg Gln Ala Leu Trp Leu Asp Glu Asn 
    130                 135                 140                 


Asp Tyr Cys Phe Arg Tyr Pro Val Pro Arg Tyr Ser Phe Arg Tyr Phe 
145                 150                 155                 160 


Thr Ile Asp Ser Gly Met Gln Gly Asn Val Thr Arg Phe Ile Asn His 
                165                 170                 175     


Ser Asp Asn Pro Asn Leu Glu Ala Ile Gly Ala Phe Glu Asn Gly Ile 
            180                 185                 190         


Phe His Ile Ile Ile Arg Ala Ile Lys Asp Ile Leu Pro Gly Glu Glu 
        195                 200                 205             


Leu Cys Tyr His Tyr Gly Pro Leu Tyr Trp Lys His Arg Lys Lys Arg 
    210                 215                 220                 


Glu Glu Phe Val Pro Gln Glu Glu Glu Phe 
225                 230                 


<210>  46
<211>  134
<212>  PRT
<213>  P. bursaria

<400>  46

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Phe Asn 
1               5                   10                  15      


Asp Arg Val Ile Val Lys Lys Ser Pro Leu Gly Gly Tyr Gly Val Phe 
            20                  25                  30          


Ala Arg Lys Ser Phe Glu Lys Gly Glu Leu Val Glu Glu Cys Leu Cys 
        35                  40                  45              


Ile Val Arg His Asn Asp Asp Trp Gly Thr Ala Leu Glu Asp Tyr Leu 
    50                  55                  60                  


Phe Ser Arg Lys Asn Met Ser Ala Met Ala Leu Gly Phe Gly Ala Ile 
65                  70                  75                  80  


Phe Asn His Ser Lys Asp Pro Asn Ala Arg His Glu Leu Thr Ala Gly 
                85                  90                  95      


Leu Lys Arg Met Arg Ile Phe Thr Ile Lys Pro Ile Ala Ile Gly Glu 
            100                 105                 110         


Glu Ile Thr Ile Ser Tyr Gly Asp Asp Tyr Trp Leu Ser Arg Pro Arg 
        115                 120                 125             


Leu Thr Gln Asn Glu Phe 
    130                 


<210>  47
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  47

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Asn Leu Lys 
1               5                   10                  15      


Cys Val Arg Ile Leu Lys Gln Phe His Lys Asp Leu Glu Arg Glu Leu 
            20                  25                  30          


Leu Arg Arg His His Arg Ser Lys Thr Pro Arg His Leu Asp Pro Ser 
        35                  40                  45              


Leu Ala Asn Tyr Leu Val Gln Lys Ala Lys Gln Arg Arg Ala Leu Arg 
    50                  55                  60                  


Arg Trp Glu Gln Glu Leu Asn Ala Lys Arg Ser His Leu Gly Arg Ile 
65                  70                  75                  80  


Thr Val Glu Asn Glu Val Asp Leu Asp Gly Pro Pro Arg Ala Phe Val 
                85                  90                  95      


Tyr Ile Asn Glu Tyr Arg Val Gly Glu Gly Ile Thr Leu Asn Gln Val 
            100                 105                 110         


Ala Val Gly Cys Glu Cys Gln Asp Cys Leu Trp Ala Pro Thr Gly Gly 
        115                 120                 125             


Cys Cys Pro Gly Ala Ser Leu His Lys Phe Ala Tyr Asn Asp Gln Gly 
    130                 135                 140                 


Gln Val Arg Leu Arg Ala Gly Leu Pro Ile Tyr Glu Cys Asn Ser Arg 
145                 150                 155                 160 


Cys Arg Cys Gly Tyr Asp Cys Pro Asn Arg Val Val Gln Lys Gly Ile 
                165                 170                 175     


Arg Tyr Asp Leu Cys Ile Phe Arg Thr Asp Asp Gly Arg Gly Trp Gly 
            180                 185                 190         


Val Arg Thr Leu Glu Lys Ile Arg Lys Asn Ser Phe Val Met Glu Tyr 
        195                 200                 205             


Val Gly Glu Ile Ile Thr Ser Glu Glu Ala Glu Arg Arg Gly Gln Ile 
    210                 215                 220                 


Tyr Asp Arg Gln Gly Ala Thr Tyr Leu Phe Asp Leu Asp Tyr Val Glu 
225                 230                 235                 240 


Asp Val Tyr Thr Val Asp Ala Ala Tyr Tyr Gly Asn Ile Ser His Phe 
                245                 250                 255     


Val Asn His Ser Cys Asp Pro Asn Leu Gln Val Tyr Asn Val Phe Ile 
            260                 265                 270         


Asp Asn Leu Asp Glu Arg Leu Pro Arg Ile Ala Phe Phe Ala Thr Arg 
        275                 280                 285             


Thr Ile Arg Ala Gly Glu Glu Leu Thr Phe Asp Tyr Asn Met Gln Val 
    290                 295                 300                 


Asp Pro Val Asp Met Glu Ser Thr Arg Met Asp Ser Asn Phe Gly Leu 
305                 310                 315                 320 


Ala Gly Leu Pro Gly Ser Pro Lys Lys Arg Val Arg Ile Glu Cys Lys 
                325                 330                 335     


Cys Gly Thr Glu Ser Cys Arg Lys Tyr Leu Phe Glu Phe 
            340                 345                 


<210>  48
<211>  346
<212>  PRT
<213>  N. crassa

<400>  48

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Glu Lys 
1               5                   10                  15      


Ala Phe Arg Pro His Phe Phe Asn His Gly Lys Pro Asp Ala Asn Pro 
            20                  25                  30          


Lys Glu Lys Lys Asn Cys His Trp Cys Gln Ile Arg Ser Phe Ala Thr 
        35                  40                  45              


His Ala Gln Leu Pro Ile Ser Ile Val Asn Arg Glu Asp Asp Ala Phe 
    50                  55                  60                  


Leu Asn Pro Asn Phe Arg Phe Ile Asp His Ser Ile Ile Gly Lys Asn 
65                  70                  75                  80  


Val Pro Val Ala Asp Gln Ser Phe Arg Val Gly Cys Ser Cys Ala Ser 
                85                  90                  95      


Asp Glu Glu Cys Met Tyr Ser Thr Cys Gln Cys Leu Asp Glu Met Ala 
            100                 105                 110         


Pro Asp Ser Asp Glu Glu Ala Asp Pro Tyr Thr Arg Lys Lys Arg Phe 
        115                 120                 125             


Ala Tyr Tyr Ser Gln Gly Ala Lys Lys Gly Leu Leu Arg Asp Arg Val 
    130                 135                 140                 


Leu Gln Ser Gln Glu Pro Ile Tyr Glu Cys His Gln Gly Cys Ala Cys 
145                 150                 155                 160 


Ser Lys Asp Cys Pro Asn Arg Val Val Glu Arg Gly Arg Thr Val Pro 
                165                 170                 175     


Leu Gln Ile Phe Arg Thr Lys Asp Arg Gly Trp Gly Val Lys Cys Pro 
            180                 185                 190         


Val Asn Ile Lys Arg Gly Gln Phe Val Asp Arg Tyr Leu Gly Glu Ile 
        195                 200                 205             


Ile Thr Ser Glu Glu Ala Asp Arg Arg Arg Ala Glu Ser Thr Ile Ala 
    210                 215                 220                 


Arg Arg Lys Asp Val Tyr Leu Phe Ala Leu Asp Lys Phe Ser Asp Pro 
225                 230                 235                 240 


Asp Ser Leu Asp Pro Leu Leu Ala Gly Gln Pro Leu Glu Val Asp Gly 
                245                 250                 255     


Glu Tyr Met Ser Gly Pro Thr Arg Phe Ile Asn His Ser Cys Asp Pro 
            260                 265                 270         


Asn Met Ala Ile Phe Ala Arg Val Gly Asp His Ala Asp Lys His Ile 
        275                 280                 285             


His Asp Leu Ala Leu Phe Ala Ile Lys Asp Ile Pro Lys Gly Thr Glu 
    290                 295                 300                 


Leu Thr Phe Asp Tyr Val Asn Gly Leu Thr Gly Leu Glu Ser Asp Ala 
305                 310                 315                 320 


His Asp Pro Ser Lys Ile Ser Glu Met Thr Lys Cys Leu Cys Gly Thr 
                325                 330                 335     


Ala Lys Cys Arg Gly Tyr Leu Trp Glu Phe 
            340                 345     


<210>  49
<211>  282
<212>  PRT
<213>  A. thaliana

<400>  49

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Asp Ile Ser 
1               5                   10                  15      


Gly Gly Leu Glu Phe Lys Gly Ile Pro Ala Thr Asn Arg Val Asp Asp 
            20                  25                  30          


Ser Pro Val Ser Pro Thr Ser Gly Phe Thr Tyr Ile Lys Ser Leu Ile 
        35                  40                  45              


Ile Glu Pro Asn Val Ile Ile Pro Lys Ser Ser Thr Gly Cys Asn Cys 
    50                  55                  60                  


Arg Gly Ser Cys Thr Asp Ser Lys Lys Cys Ala Cys Ala Lys Leu Asn 
65                  70                  75                  80  


Gly Gly Asn Phe Pro Tyr Val Asp Leu Asn Asp Gly Arg Leu Ile Glu 
                85                  90                  95      


Ser Arg Asp Val Val Phe Glu Cys Gly Pro His Cys Gly Cys Gly Pro 
            100                 105                 110         


Lys Cys Val Asn Arg Thr Ser Gln Lys Arg Leu Arg Phe Asn Leu Glu 
        115                 120                 125             


Val Phe Arg Ser Ala Lys Lys Gly Trp Ala Val Arg Ser Trp Glu Tyr 
    130                 135                 140                 


Ile Pro Ala Gly Ser Pro Val Cys Glu Tyr Ile Gly Val Val Arg Arg 
145                 150                 155                 160 


Thr Ala Asp Val Asp Thr Ile Ser Asp Asn Glu Tyr Ile Phe Glu Ile 
                165                 170                 175     


Asp Cys Gln Gln Thr Met Gln Gly Leu Gly Gly Arg Gln Arg Arg Leu 
            180                 185                 190         


Arg Asp Val Ala Val Pro Met Asn Asn Gly Val Ser Gln Ser Ser Glu 
        195                 200                 205             


Asp Glu Asn Ala Pro Glu Phe Cys Ile Asp Ala Gly Ser Thr Gly Asn 
    210                 215                 220                 


Phe Ala Arg Phe Ile Asn His Ser Cys Glu Pro Asn Leu Phe Val Gln 
225                 230                 235                 240 


Cys Val Leu Ser Ser His Gln Asp Ile Arg Leu Ala Arg Val Val Leu 
                245                 250                 255     


Phe Ala Ala Asp Asn Ile Ser Pro Met Gln Glu Leu Thr Tyr Asp Tyr 
            260                 265                 270         


Gly Tyr Ala Leu Asp Ser Val His Glu Phe 
        275                 280         


<210>  50
<211>  328
<212>  PRT
<213>  A. thaliana

<400>  50

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Gln Ser Ala 
1               5                   10                  15      


Tyr Leu His Val Ser Leu Ala Arg Ile Ser Asp Glu Asp Cys Cys Ala 
            20                  25                  30          


Asn Cys Lys Gly Asn Cys Leu Ser Ala Asp Phe Pro Cys Thr Cys Ala 
        35                  40                  45              


Arg Glu Thr Ser Gly Glu Tyr Ala Tyr Thr Lys Glu Gly Leu Leu Lys 
    50                  55                  60                  


Glu Lys Phe Leu Asp Thr Cys Leu Lys Met Lys Lys Glu Pro Asp Ser 
65                  70                  75                  80  


Phe Pro Lys Val Tyr Cys Lys Asp Cys Pro Leu Glu Arg Asp His Asp 
                85                  90                  95      


Lys Gly Thr Tyr Gly Lys Cys Asp Gly His Leu Ile Arg Lys Phe Ile 
            100                 105                 110         


Lys Glu Cys Trp Arg Lys Cys Gly Cys Asp Met Gln Cys Gly Asn Arg 
        115                 120                 125             


Val Val Gln Arg Gly Ile Arg Cys Gln Leu Gln Val Tyr Phe Thr Gln 
    130                 135                 140                 


Glu Gly Lys Gly Trp Gly Leu Arg Thr Leu Gln Asp Leu Pro Lys Gly 
145                 150                 155                 160 


Thr Phe Ile Cys Glu Tyr Ile Gly Glu Ile Leu Thr Asn Thr Glu Leu 
                165                 170                 175     


Tyr Asp Arg Asn Val Arg Ser Ser Ser Glu Arg His Thr Tyr Pro Val 
            180                 185                 190         


Thr Leu Asp Ala Asp Trp Gly Ser Glu Lys Asp Leu Lys Asp Glu Glu 
        195                 200                 205             


Ala Leu Cys Leu Asp Ala Thr Ile Cys Gly Asn Val Ala Arg Phe Ile 
    210                 215                 220                 


Asn His Arg Cys Glu Asp Ala Asn Met Ile Asp Ile Pro Ile Glu Ile 
225                 230                 235                 240 


Glu Thr Pro Asp Arg His Tyr Tyr His Ile Ala Phe Phe Thr Leu Arg 
                245                 250                 255     


Asp Val Lys Ala Met Asp Glu Leu Thr Trp Asp Tyr Met Ile Asp Phe 
            260                 265                 270         


Asn Asp Lys Ser His Pro Val Lys Ala Phe Arg Cys Cys Cys Gly Ser 
        275                 280                 285             


Glu Ser Cys Arg Asp Arg Lys Ile Lys Gly Ser Gln Gly Lys Ser Ile 
    290                 295                 300                 


Glu Arg Arg Lys Ile Val Ser Ala Lys Lys Gln Gln Gly Ser Lys Glu 
305                 310                 315                 320 


Val Ser Lys Lys Arg Lys Glu Phe 
                325             


<210>  51
<211>  303
<212>  PRT
<213>  C. elegans

<400>  51

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Gln Leu 
1               5                   10                  15      


His Glu Gln Ile Ala Asn Ile Ser Val Thr Phe Asn Asp Ile Pro Arg 
            20                  25                  30          


Ser Asp His Ser Met Thr Pro Thr Glu Leu Cys Tyr Phe Asp Asp Phe 
        35                  40                  45              


Ala Thr Thr Leu Val Val Asp Ser Val Leu Asn Phe Thr Thr His Lys 
    50                  55                  60                  


Met Ser Lys Lys Arg Arg Tyr Leu Tyr Gln Asp Glu Tyr Arg Thr Ala 
65                  70                  75                  80  


Arg Thr Val Met Lys Thr Phe Arg Glu Gln Arg Asp Trp Thr Asn Ala 
                85                  90                  95      


Ile Tyr Gly Leu Leu Thr Leu Arg Ser Val Ser His Phe Leu Ser Lys 
            100                 105                 110         


Leu Pro Pro Asn Lys Leu Phe Glu Phe Arg Asp His Ile Val Arg Phe 
        115                 120                 125             


Leu Asn Met Phe Ile Leu Asp Ser Gly Tyr Thr Ile Gln Glu Cys Lys 
    130                 135                 140                 


Arg Tyr Ser Gln Glu Gly His Gln Gly Ala Lys Leu Val Ser Thr Gly 
145                 150                 155                 160 


Val Trp Ser Arg Gly Asp Lys Ile Glu Arg Leu Ser Gly Val Val Cys 
                165                 170                 175     


Leu Leu Ser Ser Glu Asp Glu Asp Ser Ile Leu Ala Gln Glu Gly Ser 
            180                 185                 190         


Asp Phe Ser Val Met Tyr Ser Thr Arg Lys Arg Cys Ser Thr Leu Trp 
        195                 200                 205             


Leu Gly Pro Gly Ala Tyr Ile Asn His Asp Cys Arg Pro Thr Cys Glu 
    210                 215                 220                 


Phe Val Ser His Gly Ser Thr Ala His Ile Arg Val Leu Arg Asp Met 
225                 230                 235                 240 


Val Pro Gly Asp Glu Ile Thr Cys Phe Tyr Gly Ser Glu Phe Phe Gly 
                245                 250                 255     


Pro Asn Asn Ile Asp Cys Glu Cys Cys Thr Cys Glu Lys Asn Met Asn 
            260                 265                 270         


Gly Ala Phe Ser Tyr Leu Arg Gly Asn Glu Asn Ala Glu Pro Ile Ile 
        275                 280                 285             


Ser Glu Lys Lys Thr Lys Tyr Glu Leu Arg Ser Arg Ser Glu Phe 
    290                 295                 300             


<210>  52
<211>  257
<212>  PRT
<213>  C. elegans

<400>  52

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Met Lys Val 
1               5                   10                  15      


Ala Ala Lys Lys Leu Ala Thr Ser Arg Met Arg Lys Asp Arg Ala Ala 
            20                  25                  30          


Ala Ala Ser Pro Ser Ser Asp Ile Glu Asn Ser Glu Asn Pro Ser Ser 
        35                  40                  45              


Leu Ala Ser His Ser Ser Ser Ser Gly Arg Met Thr Pro Ser Lys Asn 
    50                  55                  60                  


Thr Arg Ser Arg Lys Gly Val Ser Val Lys Asp Val Ser Asn His Lys 
65                  70                  75                  80  


Ile Thr Glu Phe Phe Gln Val Arg Arg Ser Asn Arg Lys Thr Ser Lys 
                85                  90                  95      


Gln Ile Ser Asp Glu Ala Lys His Ala Leu Arg Asp Thr Val Leu Lys 
            100                 105                 110         


Gly Thr Asn Glu Arg Leu Leu Glu Val Tyr Lys Asp Val Val Lys Gly 
        115                 120                 125             


Arg Gly Ile Arg Thr Lys Val Asn Phe Glu Lys Gly Asp Phe Val Val 
    130                 135                 140                 


Glu Tyr Arg Gly Val Met Met Glu Tyr Ser Glu Ala Lys Val Ile Glu 
145                 150                 155                 160 


Glu Gln Tyr Ser Asn Asp Glu Glu Ile Gly Ser Tyr Met Tyr Phe Phe 
                165                 170                 175     


Glu His Asn Asn Lys Lys Trp Cys Ile Asp Ala Thr Lys Glu Ser Pro 
            180                 185                 190         


Trp Lys Gly Arg Leu Ile Asn His Ser Val Leu Arg Pro Asn Leu Lys 
        195                 200                 205             


Thr Lys Val Val Glu Ile Asp Gly Ser His His Leu Ile Leu Val Ala 
    210                 215                 220                 


Arg Arg Gln Ile Ala Gln Gly Glu Glu Leu Leu Tyr Asp Tyr Gly Asp 
225                 230                 235                 240 


Arg Ser Ala Glu Thr Ile Ala Lys Asn Pro Trp Leu Val Asn Thr Glu 
                245                 250                 255     


Phe 
    


<210>  53
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  53

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Ser Cys Asp 
1               5                   10                  15      


Ser Thr Asn Ala Ala Ile Ala Lys Gln Ala Leu Lys Lys Pro Ile Lys 
            20                  25                  30          


Gly Lys Gln Ala Pro Arg Lys Lys Ala Gln Gly Lys Thr Gln Gln Asn 
        35                  40                  45              


Arg Lys Leu Thr Asp Phe Tyr Pro Val Arg Arg Ser Ser Arg Lys Ser 
    50                  55                  60                  


Lys Ala Glu Leu Gln Ser Glu Glu Arg Lys Arg Ile Asp Glu Leu Ile 
65                  70                  75                  80  


Glu Ser Gly Lys Glu Glu Gly Met Lys Ile Asp Leu Ile Asp Gly Lys 
                85                  90                  95      


Gly Arg Gly Val Ile Ala Thr Lys Gln Phe Ser Arg Gly Asp Phe Val 
            100                 105                 110         


Val Glu Tyr His Gly Asp Leu Ile Glu Ile Thr Asp Ala Lys Lys Arg 
        115                 120                 125             


Glu Ala Leu Tyr Ala Gln Asp Pro Ser Thr Gly Cys Tyr Met Tyr Tyr 
    130                 135                 140                 


Phe Gln Tyr Leu Ser Lys Thr Tyr Cys Val Asp Ala Thr Arg Glu Thr 
145                 150                 155                 160 


Asn Arg Leu Gly Arg Leu Ile Asn His Ser Lys Cys Gly Asn Cys Gln 
                165                 170                 175     


Thr Lys Leu His Asp Ile Asp Gly Val Pro His Leu Ile Leu Ile Ala 
            180                 185                 190         


Ser Arg Asp Ile Ala Ala Gly Glu Glu Leu Leu Tyr Asp Tyr Gly Asp 
        195                 200                 205             


Arg Ser Lys Ala Ser Ile Glu Ala Phe Pro Trp Leu Lys His Glu Phe 
    210                 215                 220                 


<210>  54
<211>  319
<212>  PRT
<213>  T. gondii

<400>  54

Ala Ser Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser Ala Ser Arg 
1               5                   10                  15      


Arg Thr Gly Glu Phe Leu Arg Asp Ala Gln Ala Pro Ser Arg Trp Leu 
            20                  25                  30          


Lys Arg Ser Lys Thr Gly Gln Asp Asp Gly Ala Phe Cys Leu Glu Thr 
        35                  40                  45              


Trp Leu Ala Gly Ala Gly Asp Asp Ala Ala Gly Gly Glu Arg Gly Arg 
    50                  55                  60                  


Asp Arg Glu Gly Ala Ala Asp Lys Ala Lys Gln Arg Glu Glu Arg Arg 
65                  70                  75                  80  


Gln Lys Glu Leu Glu Glu Arg Phe Glu Glu Met Lys Val Glu Phe Glu 
                85                  90                  95      


Glu Lys Ala Gln Arg Met Ile Ala Arg Arg Ala Ala Leu Thr Gly Glu 
            100                 105                 110         


Ile Tyr Ser Asp Gly Lys Gly Ser Lys Lys Pro Arg Val Pro Ser Leu 
        115                 120                 125             


Pro Glu Asn Asp Asp Asp Ala Leu Ile Glu Ile Ile Ile Asp Pro Glu 
    130                 135                 140                 


Gln Gly Ile Leu Lys Trp Pro Leu Ser Val Met Ser Ile Arg Gln Arg 
145                 150                 155                 160 


Thr Val Ile Tyr Gln Glu Cys Leu Arg Arg Asp Leu Thr Ala Cys Ile 
                165                 170                 175     


His Leu Thr Lys Val Pro Gly Lys Gly Arg Ala Val Phe Ala Ala Asp 
            180                 185                 190         


Thr Ile Leu Lys Asp Asp Phe Val Val Glu Tyr Lys Gly Glu Leu Cys 
        195                 200                 205             


Ser Glu Arg Glu Ala Arg Glu Arg Glu Gln Arg Tyr Asn Arg Ser Lys 
    210                 215                 220                 


Val Pro Met Gly Ser Phe Met Phe Tyr Phe Lys Asn Gly Ser Arg Met 
225                 230                 235                 240 


Met Ala Ile Asp Ala Thr Asp Glu Lys Gln Asp Phe Gly Pro Ala Arg 
                245                 250                 255     


Leu Ile Asn His Ser Arg Arg Asn Pro Asn Met Thr Pro Arg Ala Ile 
            260                 265                 270         


Thr Leu Gly Asp Phe Asn Ser Glu Pro Arg Leu Ile Phe Val Ala Arg 
        275                 280                 285             


Arg Asn Ile Glu Lys Gly Glu Glu Leu Leu Val Asp Tyr Gly Glu Arg 
    290                 295                 300                 


Asp Pro Asp Val Ile Lys Glu His Pro Trp Leu Asn Ser Glu Phe 
305                 310                 315                 


<210>  55
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  55

Gly Ser Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
1               5                   10                  15      


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
            20                  25                  30          


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
        35                  40                  45              


Asp Phe Asp Leu Asp Met Leu Ile Asn 
    50                  55          


<210>  56
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  56

Ala Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly 
1               5                   10                  15      


Glu Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu 
            20                  25                  30          


Asp Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His 
        35                  40                  45              


Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu 
    50                  55                  60                  


Gln Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly Glu Phe 
65                  70                  75                  80  


Pro Gly Ile Arg Arg 
                85  


<210>  57
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  57

Pro Ser Gly Gln Ile Ser Asn Gln Ala Leu Ala Leu Ala Pro Ser Ser 
1               5                   10                  15      


Ala Pro Val Leu Ala Gln Thr Met Val Pro Ser Ser Ala Met Val Pro 
            20                  25                  30          


Leu Ala Gln Pro Pro Ala Pro Ala Pro Val Leu Thr Pro Gly Pro Pro 
        35                  40                  45              


Gln Ser Leu Ser Ala Pro Val Pro Lys Ser Thr Gln Ala Gly Glu Gly 
    50                  55                  60                  


Thr Leu Ser Glu Ala Leu Leu His Leu Gln Phe Asp Ala Asp Glu Asp 
65                  70                  75                  80  


Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Gly Val Phe Thr Asp 
                85                  90                  95      


Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly 
            100                 105                 110         


Val Ser Met Ser His Ser Thr Ala Glu Pro Met Leu Met Glu Tyr Pro 
        115                 120                 125             


Glu Ala Ile Thr Arg Leu Val Thr Gly Ser Gln Arg Pro Pro Asp Pro 
    130                 135                 140                 


Ala Pro Thr Pro Leu Gly Thr Ser Gly Leu Pro Asn Gly Leu Ser Gly 
145                 150                 155                 160 


Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu 
                165                 170                 175     


Ser Gln Ile Ser Ser Ser Gly Gln 
            180                 


<210>  58
<211>  1467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  58

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Gly Ser  Pro Lys Lys Lys Arg  Lys Val Ser Ser Asp  Tyr Lys Asp 
    1370                 1375                 1380             


His Asp  Gly Asp Tyr Lys Asp  His Asp Ile Asp Tyr  Lys Asp Asp 
    1385                 1390                 1395             


Asp Asp  Lys Ala Ala Gly Gly  Gly Gly Ser Gly Arg  Ala Asp Ala 
    1400                 1405                 1410             


Leu Asp  Asp Phe Asp Leu Asp  Met Leu Gly Ser Asp  Ala Leu Asp 
    1415                 1420                 1425             


Asp Phe  Asp Leu Asp Met Leu  Gly Ser Asp Ala Leu  Asp Asp Phe 
    1430                 1435                 1440             


Asp Leu  Asp Met Leu Gly Ser  Asp Ala Leu Asp Asp  Phe Asp Leu 
    1445                 1450                 1455             


Asp Met  Leu His His His His  His His 
    1460                 1465         


<210>  59
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Asn Met Phe Lys Glu Ala Val Thr Phe Lys Asp Val Ala Val Ala 
1               5                   10                  15      


Phe Thr Glu Glu Glu Leu Gly Leu Leu Gly Pro Ala Gln Arg Lys Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Val Glu Asn Phe Arg Asn Leu Leu Ser Val Gly 
        35                  40                  45              


His Pro Pro Phe Lys Gln Asp Val Ser Pro Ile Glu Arg Asn Glu Gln 
    50                  55                  60                  


Leu Trp Ile Met Thr Thr Ala Thr Arg Arg Gln Gly Asn Leu Asp Thr 
65                  70                  75                  80  


Leu Pro Val Lys Ala Leu Leu Leu Tyr Asp Leu Ala Gln Thr 
                85                  90                  


<210>  60
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  60

Glu Gln Val Ser Phe Lys Asp Val Cys Val Asp Phe Thr Gln Glu Glu 
1               5                   10                  15      


Trp Tyr Leu Leu Asp Pro Ala Gln Lys Ile Leu Tyr Arg Asp Val Ile 
            20                  25                  30          


Leu Glu Asn Tyr Ser Asn Leu Val Ser Val Gly Tyr Cys Ile Thr Lys 
        35                  40                  45              


Pro Glu Val Ile Phe Lys Ile Glu Gln Gly Glu Glu Pro Trp Ile Leu 
    50                  55                  60                  


Glu Lys Gly Phe Pro Ser Gln Cys His Pro 
65                  70                  


<210>  61
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  61

Glu Ala Val Thr Phe Lys Asp Val Ala Val Val Phe Thr Glu Glu Glu 
1               5                   10                  15      


Leu Gly Leu Leu Asp Pro Ala Gln Arg Lys Leu Tyr Arg Asp Val Met 
            20                  25                  30          


Leu Glu Asn Phe Arg Asn Leu Leu Ser Val 
        35                  40          


<210>  62
<211>  69
<212>  PRT
<213>  Mus musculus

<400>  62

Met Asp Leu Val Thr Tyr Asp Asp Val His Val Asn Phe Thr Gln Asp 
1               5                   10                  15      


Glu Trp Ala Leu Leu Asp Pro Ser Gln Lys Ser Leu Tyr Lys Gly Val 
            20                  25                  30          


Met Leu Glu Thr Tyr Lys Asn Leu Thr Ala Ile Gly Tyr Ile Trp Glu 
        35                  40                  45              


Glu His Thr Ile Glu Asp His Phe Gln Thr Ser Arg Ser His Gly Ser 
    50                  55                  60                  


Asn Lys Lys Thr His 
65                  


<210>  63
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  63

Gly Ser Gly Met Asn Ile Gln Met Leu Leu Glu Ala Ala Asp Tyr Leu 
1               5                   10                  15      


Glu Arg Arg Glu Arg Glu Ala Glu His Gly Tyr Ala Ser Met Leu Pro 
            20                  25                  30          


<210>  64
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  64

Gly Ser Gly Met Asn Ile Gln Met Leu Leu Glu Ala Ala Asp Tyr Leu 
1               5                   10                  15      


Glu Arg Arg Glu Arg Glu Ala Glu His Gly Tyr Ala Ser Met Leu Pro 
            20                  25                  30          


Gly Ser Gly Met Asn Ile Gln Met Leu Leu Glu Ala Ala Asp Tyr Leu 
        35                  40                  45              


Glu Arg Arg Glu Arg Glu Ala Glu His Gly Tyr Ala Ser Met Leu Pro 
    50                  55                  60                  


Gly Ser Gly Met Asn Ile Gln Met Leu Leu Glu Ala Ala Asp Tyr Leu 
65                  70                  75                  80  


Glu Arg Arg Glu Arg Glu Ala Glu His Gly Tyr Ala Ser Met Leu Pro 
                85                  90                  95      


Gly Ser Gly Met Asn Ile Gln Met Leu Leu Glu Ala Ala Asp Tyr Leu 
            100                 105                 110         


Glu Arg Arg Glu Arg Glu Ala Glu His Gly Tyr Ala Ser Met Leu Pro 
        115                 120                 125             


Ser Arg 
    130 


<210>  65
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  65

Ser Gly Gly Ser 
1               


<210>  66
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(60)
<223>  may be absent

<400>  66

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
1               5                   10                  15      


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
        35                  40                  45              


Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Gly Ser 
    50                  55                  60  


<210>  67
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(60)
<223>  may be absent

<400>  67

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    50                  55                  60  


<210>  68
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(75)
<223>  may be absent

<400>  68

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75  


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(15)
<223>  may be absent

<400>  69

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15  


<210>  70
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(75)
<223>  may be absent

<400>  70

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala 
        35                  40                  45              


Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
    50                  55                  60                  


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
65                  70                  75  


<210>  71
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(45)
<223>  may be absent

<400>  71

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        35                  40                  45  


<210>  72
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(30)
<223>  may be absent

<400>  72

Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro 
1               5                   10                  15      


Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro 
            20                  25                  30  


<210>  73
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  73

Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 
1               5                   10                  15      


Thr Pro Glu Ser Ser Gly Gly Ser 
            20                  


<210>  74
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  74

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


<210>  75
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  75

Gly Gly Ser Gly Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 
1               5                   10                  15      


Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 
            20                  25                  30          


Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 
        35                  40                  45              


Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 
    50                  55                  60                  


Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 
65                  70                  75                  80  


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 
                85                  90                  95      


Thr Ser Gly Gly Ser Gly Gly Ser 
            100                 


<210>  76
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any amino acid

<400>  76

Xaa Ala Gly Val Phe Xaa 
1               5       


<210>  77
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any amino acid

<400>  77

Xaa Gly Phe Leu Gly Xaa 
1               5       


<210>  78
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any amino acid

<400>  78

Xaa Ala Leu Ala Leu Xaa 
1               5       


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any amino acid

<400>  79

Xaa Ala Leu Ala Leu Ala Xaa 
1               5           


<210>  80
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  80

Met Gly Ala Ser Asp Ala Ala Val Asp Thr Ser Ser Glu Ile Thr Thr 
1               5                   10                  15      


Lys Asp Leu Lys Glu Lys Lys Glu Val Val Glu Glu Ala Glu Asn Gly 
            20                  25                  30          


Arg Asp Ala Pro Ala Asn Gly Asn Ala Glu Asn Glu Glu Asn Gly Glu 
        35                  40                  45              


Gln Glu Ala Asp Asn Glu Val Asp Glu Glu Glu Glu Glu Gly Gly Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Glu Glu Gly Asp Gly Glu Glu Glu Asp Gly Asp 
65                  70                  75                  80  


Glu Asp Glu Glu Ala Glu Ser Ala Thr Gly Lys Arg Ala Ala Glu Asp 
                85                  90                  95      


Asp Glu Asp Asp Asp Val Asp Thr Lys Lys Gln Lys Thr Asp Glu Asp 
            100                 105                 110         


Asp Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Thr Ala Ser Asn 
    130                 135                 140                 


Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val Asp Ala Thr 
145                 150                 155                 160 


Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg Asp Arg Gln 
                165                 170                 175     


Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val Cys Arg Ser 
            180                 185                 190         


Trp Ala Ala Trp Cys Lys Leu Asn Asn Arg Lys Trp Phe Pro Ala Glu 
        195                 200                 205             


Pro Glu Asp Val Arg Asp Tyr Leu Leu Tyr Leu Gln Ala Arg Gly Leu 
    210                 215                 220                 


Ala Val Lys Thr Ile Gln Gln His Leu Gly Gln Leu Asn Met Leu His 
225                 230                 235                 240 


Arg Arg Ser Gly Leu Pro Arg Pro Ser Asp Ser Asn Ala Val Ser Leu 
                245                 250                 255     


Val Met Arg Arg Ile Arg Lys Glu Asn Val Asp Ala Gly Glu Arg Ala 
            260                 265                 270         


Lys Gln Ala Leu Ala Phe Glu Arg Thr Asp Phe Asp Gln Val Arg Ser 
        275                 280                 285             


Leu Met Glu Asn Ser Asp Arg Cys Gln Asp Ile Arg Asn Leu Ala Phe 
    290                 295                 300                 


Leu Gly Ile Ala Tyr Asn Thr Leu Leu Arg Ile Ala Glu Ile Ala Arg 
305                 310                 315                 320 


Ile Arg Val Lys Asp Ile Ser Arg Thr Asp Gly Gly Arg Met Leu Ile 
                325                 330                 335     


His Ile Gly Arg Thr Lys Thr Leu Val Ser Thr Ala Gly Val Glu Lys 
            340                 345                 350         


Ala Leu Ser Leu Gly Val Thr Lys Leu Val Glu Arg Trp Ile Ser Val 
        355                 360                 365             


Ser Gly Val Ala Asp Asp Pro Asn Asn Tyr Leu Phe Cys Arg Val Arg 
    370                 375                 380                 


Lys Asn Gly Val Ala Ala Pro Ser Ala Thr Ser Gln Leu Ser Thr Arg 
385                 390                 395                 400 


Ala Leu Glu Gly Ile Phe Glu Ala Thr His Arg Leu Ile Tyr Gly Ala 
                405                 410                 415     


Lys Asp Asp Ser Gly Gln Arg Tyr Leu Ala Trp Ser Gly His Ser Ala 
            420                 425                 430         


Arg Val Gly Ala Ala Arg Asp Met Ala Arg Ala Gly Val Ser Ile Pro 
        435                 440                 445             


Glu Ile Met Gln Ala Gly Gly Trp Thr Asn Val Asn Ile Val Met Asn 
    450                 455                 460                 


Tyr Ile Arg Asn Leu Asp Ser Glu Thr Gly Ala Met Val Arg Leu Leu 
465                 470                 475                 480 


Glu Asp Gly Asp Gly Gly Ser His His His His His His 
                485                 490             


<210>  81
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  81

Met Gly Ala Ser Lys Gly Glu Glu Leu Phe Asp Gly Val Val Pro Ile 
1               5                   10                  15      


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Glu Phe Ser Val Arg 
            20                  25                  30          


Gly Glu Gly Glu Gly Asp Ala Thr Glu Gly Glu Leu Thr Leu Lys Phe 
        35                  40                  45              


Ile Cys Thr Thr Gly Glu Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
    50                  55                  60                  


Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Asp Tyr Pro Asp His Met 
65                  70                  75                  80  


Asp Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
                85                  90                  95      


Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala 
            100                 105                 110         


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
        115                 120                 125             


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
    130                 135                 140                 


Tyr Asn Phe Asn Ser His Asp Val Tyr Ile Thr Ala Asp Lys Gln Glu 
145                 150                 155                 160 


Asn Gly Ile Lys Ala Glu Phe Glu Ile Arg His Asn Val Glu Asp Gly 
                165                 170                 175     


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
            180                 185                 190         


Gly Pro Val Leu Leu Pro Asp Asp His Tyr Leu Ser Thr Glu Ser Ala 
        195                 200                 205             


Leu Ser Lys Asp Pro Asn Glu Asp Arg Asp His Met Val Leu Leu Glu 
    210                 215                 220                 


Phe Val Thr Ala Ala Gly Ile Asp His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 240 


Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                245                 250                 255     


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Thr Ala Ser Asn Leu 
            260                 265                 270         


Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val Asp Ala Thr Ser 
        275                 280                 285             


Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg Asp Arg Gln Ala 
    290                 295                 300                 


Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val Cys Arg Ser Trp 
305                 310                 315                 320 


Ala Ala Trp Cys Lys Leu Asn Asn Arg Lys Trp Phe Pro Ala Glu Pro 
                325                 330                 335     


Glu Asp Val Arg Asp Tyr Leu Leu Tyr Leu Gln Ala Arg Gly Leu Ala 
            340                 345                 350         


Val Lys Thr Ile Gln Gln His Leu Gly Gln Leu Asn Met Leu His Arg 
        355                 360                 365             


Arg Ser Gly Leu Pro Arg Pro Ser Asp Ser Asn Ala Val Ser Leu Val 
    370                 375                 380                 


Met Arg Arg Ile Arg Lys Glu Asn Val Asp Ala Gly Glu Arg Ala Lys 
385                 390                 395                 400 


Gln Ala Leu Ala Phe Glu Arg Thr Asp Phe Asp Gln Val Arg Ser Leu 
                405                 410                 415     


Met Glu Asn Ser Asp Arg Cys Gln Asp Ile Arg Asn Leu Ala Phe Leu 
            420                 425                 430         


Gly Ile Ala Tyr Asn Thr Leu Leu Arg Ile Ala Glu Ile Ala Arg Ile 
        435                 440                 445             


Arg Val Lys Asp Ile Ser Arg Thr Asp Gly Gly Arg Met Leu Ile His 
    450                 455                 460                 


Ile Gly Arg Thr Lys Thr Leu Val Ser Thr Ala Gly Val Glu Lys Ala 
465                 470                 475                 480 


Leu Ser Leu Gly Val Thr Lys Leu Val Glu Arg Trp Ile Ser Val Ser 
                485                 490                 495     


Gly Val Ala Asp Asp Pro Asn Asn Tyr Leu Phe Cys Arg Val Arg Lys 
            500                 505                 510         


Asn Gly Val Ala Ala Pro Ser Ala Thr Ser Gln Leu Ser Thr Arg Ala 
        515                 520                 525             


Leu Glu Gly Ile Phe Glu Ala Thr His Arg Leu Ile Tyr Gly Ala Lys 
    530                 535                 540                 


Asp Asp Ser Gly Gln Arg Tyr Leu Ala Trp Ser Gly His Ser Ala Arg 
545                 550                 555                 560 


Val Gly Ala Ala Arg Asp Met Ala Arg Ala Gly Val Ser Ile Pro Glu 
                565                 570                 575     


Ile Met Gln Ala Gly Gly Trp Thr Asn Val Asn Ile Val Met Asn Tyr 
            580                 585                 590         


Ile Arg Asn Leu Asp Ser Glu Thr Gly Ala Met Val Arg Leu Leu Glu 
        595                 600                 605             


Asp Gly Asp Gly Gly Ser His His His His His His 
    610                 615                 620 


<210>  82
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  82

Met Gly Ala Asp Glu Glu Glu Ser Asp Glu Glu Glu Leu Asp Glu Glu 
1               5                   10                  15      


Glu Asp Glu Leu Glu Glu Asp Glu Asp Thr Asp Glu Glu Gly Gly Asp 
            20                  25                  30          


Glu Glu Leu Glu Asp Glu Leu Asp Glu Thr Gly Gly Ser Gly Gly Ser 
        35                  40                  45              


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    50                  55                  60                  


Gly Ser Gly Gly Thr Ala Ser Asn Leu Leu Thr Val His Gln Asn Leu 
65                  70                  75                  80  


Pro Ala Leu Pro Val Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu 
                85                  90                  95      


Met Asp Met Phe Arg Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys 
            100                 105                 110         


Met Leu Leu Ser Val Cys Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn 
        115                 120                 125             


Asn Arg Lys Trp Phe Pro Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu 
    130                 135                 140                 


Leu Tyr Leu Gln Ala Arg Gly Leu Ala Val Lys Thr Ile Gln Gln His 
145                 150                 155                 160 


Leu Gly Gln Leu Asn Met Leu His Arg Arg Ser Gly Leu Pro Arg Pro 
                165                 170                 175     


Ser Asp Ser Asn Ala Val Ser Leu Val Met Arg Arg Ile Arg Lys Glu 
            180                 185                 190         


Asn Val Asp Ala Gly Glu Arg Ala Lys Gln Ala Leu Ala Phe Glu Arg 
        195                 200                 205             


Thr Asp Phe Asp Gln Val Arg Ser Leu Met Glu Asn Ser Asp Arg Cys 
    210                 215                 220                 


Gln Asp Ile Arg Asn Leu Ala Phe Leu Gly Ile Ala Tyr Asn Thr Leu 
225                 230                 235                 240 


Leu Arg Ile Ala Glu Ile Ala Arg Ile Arg Val Lys Asp Ile Ser Arg 
                245                 250                 255     


Thr Asp Gly Gly Arg Met Leu Ile His Ile Gly Arg Thr Lys Thr Leu 
            260                 265                 270         


Val Ser Thr Ala Gly Val Glu Lys Ala Leu Ser Leu Gly Val Thr Lys 
        275                 280                 285             


Leu Val Glu Arg Trp Ile Ser Val Ser Gly Val Ala Asp Asp Pro Asn 
    290                 295                 300                 


Asn Tyr Leu Phe Cys Arg Val Arg Lys Asn Gly Val Ala Ala Pro Ser 
305                 310                 315                 320 


Ala Thr Ser Gln Leu Ser Thr Arg Ala Leu Glu Gly Ile Phe Glu Ala 
                325                 330                 335     


Thr His Arg Leu Ile Tyr Gly Ala Lys Asp Asp Ser Gly Gln Arg Tyr 
            340                 345                 350         


Leu Ala Trp Ser Gly His Ser Ala Arg Val Gly Ala Ala Arg Asp Met 
        355                 360                 365             


Ala Arg Ala Gly Val Ser Ile Pro Glu Ile Met Gln Ala Gly Gly Trp 
    370                 375                 380                 


Thr Asn Val Asn Ile Val Met Asn Tyr Ile Arg Asn Leu Asp Ser Glu 
385                 390                 395                 400 


Thr Gly Ala Met Val Arg Leu Leu Glu Asp Gly Asp Gly Gly Ser His 
                405                 410                 415     


His His His His His 
            420     


<210>  83
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  83

Met Gly Ala Asp Glu Glu Glu Ser Asp Glu Glu Glu Leu Asp Glu Glu 
1               5                   10                  15      


Glu Asp Glu Leu Glu Glu Asp Glu Asp Thr Asp Glu Glu Gly Gly Asp 
            20                  25                  30          


Glu Glu Leu Glu Asp Glu Leu Asp Glu Asp Glu Glu Thr Asp Asp Glu 
        35                  40                  45              


Glu Ser Asp Glu Asp Glu Asp Glu Glu Thr Gly Gly Ser Gly Gly Ser 
    50                  55                  60                  


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Thr Ala Ser Asn Leu Leu Thr Val His Gln Asn Leu 
                85                  90                  95      


Pro Ala Leu Pro Val Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu 
            100                 105                 110         


Met Asp Met Phe Arg Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys 
        115                 120                 125             


Met Leu Leu Ser Val Cys Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn 
    130                 135                 140                 


Asn Arg Lys Trp Phe Pro Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu 
145                 150                 155                 160 


Leu Tyr Leu Gln Ala Arg Gly Leu Ala Val Lys Thr Ile Gln Gln His 
                165                 170                 175     


Leu Gly Gln Leu Asn Met Leu His Arg Arg Ser Gly Leu Pro Arg Pro 
            180                 185                 190         


Ser Asp Ser Asn Ala Val Ser Leu Val Met Arg Arg Ile Arg Lys Glu 
        195                 200                 205             


Asn Val Asp Ala Gly Glu Arg Ala Lys Gln Ala Leu Ala Phe Glu Arg 
    210                 215                 220                 


Thr Asp Phe Asp Gln Val Arg Ser Leu Met Glu Asn Ser Asp Arg Cys 
225                 230                 235                 240 


Gln Asp Ile Arg Asn Leu Ala Phe Leu Gly Ile Ala Tyr Asn Thr Leu 
                245                 250                 255     


Leu Arg Ile Ala Glu Ile Ala Arg Ile Arg Val Lys Asp Ile Ser Arg 
            260                 265                 270         


Thr Asp Gly Gly Arg Met Leu Ile His Ile Gly Arg Thr Lys Thr Leu 
        275                 280                 285             


Val Ser Thr Ala Gly Val Glu Lys Ala Leu Ser Leu Gly Val Thr Lys 
    290                 295                 300                 


Leu Val Glu Arg Trp Ile Ser Val Ser Gly Val Ala Asp Asp Pro Asn 
305                 310                 315                 320 


Asn Tyr Leu Phe Cys Arg Val Arg Lys Asn Gly Val Ala Ala Pro Ser 
                325                 330                 335     


Ala Thr Ser Gln Leu Ser Thr Arg Ala Leu Glu Gly Ile Phe Glu Ala 
            340                 345                 350         


Thr His Arg Leu Ile Tyr Gly Ala Lys Asp Asp Ser Gly Gln Arg Tyr 
        355                 360                 365             


Leu Ala Trp Ser Gly His Ser Ala Arg Val Gly Ala Ala Arg Asp Met 
    370                 375                 380                 


Ala Arg Ala Gly Val Ser Ile Pro Glu Ile Met Gln Ala Gly Gly Trp 
385                 390                 395                 400 


Thr Asn Val Asn Ile Val Met Asn Tyr Ile Arg Asn Leu Asp Ser Glu 
                405                 410                 415     


Thr Gly Ala Met Val Arg Leu Leu Glu Asp Gly Asp Gly Gly Ser His 
            420                 425                 430         


His His His His His 
        435         


<210>  84
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  84

Met Gly Ala Ser Asp Ala Ala Val Asp Thr Ser Ser Glu Ile Thr Thr 
1               5                   10                  15      


Lys Asp Leu Lys Glu Lys Lys Glu Val Val Glu Glu Ala Glu Asn Gly 
            20                  25                  30          


Arg Asp Ala Pro Ala Asn Gly Asn Ala Glu Asn Glu Glu Asn Gly Glu 
        35                  40                  45              


Gln Glu Ala Asp Asn Glu Val Asp Glu Glu Glu Glu Glu Gly Gly Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Glu Glu Gly Asp Gly Glu Glu Glu Asp Gly Asp 
65                  70                  75                  80  


Glu Asp Glu Glu Ala Glu Ser Ala Thr Gly Lys Arg Ala Ala Glu Asp 
                85                  90                  95      


Asp Glu Asp Asp Asp Val Asp Thr 
            100                 


<210>  85
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  85

Met Gly Ala Glu Ser Ala Thr Gly Lys Arg Ala Ala Glu Asp Asp Glu 
1               5                   10                  15      


Asp Asp Asp Val Asp Thr Lys Lys Gln Lys Thr Asp Glu Asp Asp 
            20                  25                  30      


<210>  86
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  86

Met Gly Ala Glu Asn Glu Glu Asn Gly Glu Gln Glu Ala Asp Asn Glu 
1               5                   10                  15      


Val Asp Glu Glu Glu Glu Glu Gly Gly Glu Glu Glu Glu Glu Glu Glu 
            20                  25                  30          


Glu Gly Asp Gly Glu Glu Glu Asp Gly Asp Glu Asp Glu Glu Ala Glu 
        35                  40                  45              


Ser Ala Thr Gly Lys Arg Ala Ala Glu Asp Asp Glu Asp Asp Asp Val 
    50                  55                  60                  


Asp Thr Lys Lys Gln Lys Thr Asp Glu Asp Asp 
65                  70                  75  


<210>  87
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  87

Met Gly Ala Ser Asp Ala Ala Val Asp Thr Ser Ser Glu Ile Thr Thr 
1               5                   10                  15      


Lys Asp Leu Lys Glu Lys Lys Glu Val Val Glu Glu Ala Glu Asn Gly 
            20                  25                  30          


Arg Asp Ala Pro Ala Asn Gly Asn Ala Glu Ser Ala Thr Gly Lys Arg 
        35                  40                  45              


Ala Ala Glu Asp Asp Glu Asp Asp Asp Val Asp Thr Lys Lys Gln Lys 
    50                  55                  60                  


Thr Asp Glu Asp Asp 
65                  


<210>  88
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  88

Met Gly Ala Ser Asp Ala Ala Val Asp Thr Ser Ser Glu Ile Thr Thr 
1               5                   10                  15      


Lys Asp Leu Lys Glu Lys Lys Glu Val Val Glu Glu Ala Glu Asn Gly 
            20                  25                  30          


Arg Asp Ala Pro Ala Asn Gly Asn Ala Glu Asn Glu Glu Asn Gly Glu 
        35                  40                  45              


Gln Glu Ala Asp Asn Glu Val Asp Glu Glu Glu Glu Glu Gly Gly Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Glu Glu Gly Asp Gly Glu Glu Glu Asp Gly Asp 
65                  70                  75                  80  


Glu Asp Glu Glu Ala Glu Ser Ala Thr Gly Lys Arg Ala Ala Glu Asp 
                85                  90                  95      


Asp Glu Asp Asp Asp Val Asp Thr Lys Lys Gln Lys Thr Asp Glu Asp 
            100                 105                 110         


Asp 
    


<210>  89
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  89

Met Gly Ala Asp Glu Glu Glu Ser Asp Glu Glu Glu Leu Asp Glu Glu 
1               5                   10                  15      


Glu Asp Glu Leu Glu Glu Asp Glu Asp Thr Asp Glu Glu Gly Gly Asp 
            20                  25                  30          


Glu Glu Leu Glu Asp Glu Leu Asp Glu Asp Glu Glu Thr Asp Asp Glu 
        35                  40                  45              


Glu Ser Asp Glu Asp Glu Asp Glu Glu 
    50                  55          


<210>  90
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  90

Met Gly Ala Asp Glu Glu Glu Ser Asp Glu Glu Glu Leu Asp Glu Glu 
1               5                   10                  15      


Glu Asp Glu Leu Glu Glu Asp Glu Asp Thr Asp Glu Glu Gly Gly Asp 
            20                  25                  30          


Glu Glu Leu Glu Asp Glu Leu Asp Glu 
        35                  40      


