                         SEQUENCE LISTING

<110>  KORRO BIO, INC.
 
<120>  RNA-EDITING OLIGONUCLEOTIDES AND USES THEREOF

<130>  51348-005WO4

<140>  PCT/US2020/014511
<141>  2020-01-22

<150>  US 62/900,017
<151>  2019-09-13

<150>  US 62/822,586
<151>  2019-03-22

<150>  US 62/795,348
<151>  2019-01-22

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
ggugaauagu auaacaauau                                                   20


<210>  2
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2
auguuguuau aguauccacc                                                   20


<210>  3
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3
ggugaauagu auaacaauau gcuaaauguu guuauaguau ccacc                       45


<210>  4
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4
ggugaagagg agaacaauau                                                   20


<210>  5
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5
auguuguucu cgucuccacc                                                   20


<210>  6
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6
ggugaagagg agaacaauau gcuaaauguu guucucgucu ccacc                       45


<210>  7
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
ggugucgaga agaggagaac aauau                                             25


<210>  8
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
auguuguucu cgucuccucg acacc                                             25


<210>  9
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacc            55


<210>  10
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
ggguggaaua guauaacaau au                                                22


<210>  11
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
auguuguuau aguaucccac cu                                                22


<210>  12
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210>  13
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
guggaauagu auaacaauau                                                   20


<210>  14
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
auguuguuau aguaucccac                                                   20


<210>  15
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
guggaauagu auaacaauau gcuaaauguu guuauaguau cccac                       45


<210>  16
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
ggugucgaga auaguauaac aauau                                             25


<210>  17
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
auguuguuau aguauccucg acacc                                             25


<210>  18
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18
ggugucgaga auaguauaac aauaugcuaa auguuguuau aguauccucg acacc            55


<210>  19
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19
ggguggaaua guauaacaau au                                                22


<210>  20
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20
auguuguuau aguaucccac cu                                                22


<210>  21
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210>  22
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22
ggguggaaua guauacca                                                     18


<210>  23
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23
ugguauagua ucccaccu                                                     18


<210>  24
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24
ggguggaaua guauaccauu cgugguauag uaucccaccu                             40


<210>  25
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25
guggguggaa uaguauacca                                                   20


<210>  26
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26
ugguauagua ucccaccuac                                                   20


<210>  27
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27
guggguggaa uaguauacca uucgugguau aguaucccac cuac                        44


<210>  28
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28
uggguggaau aguauacca                                                    19


<210>  29
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29
ugguauagua ucccaccua                                                    19


<210>  30
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30
uggguggaau aguauaccau ucgugguaua guaucccacc ua                          42


<210>  31
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31
gguggaauag uauacca                                                      17


<210>  32
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32
ugguauagua ucccacc                                                      17


<210>  33
<211>  38
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33
gguggaauag uauaccauuc gugguauagu aucccacc                               38


<210>  34
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34
guggaauagu auacca                                                       16


<210>  35
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35
ugguauagua ucccac                                                       16


<210>  36
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36
guggaauagu auaccauucg ugguauagua ucccac                                 36


<210>  37
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37
ggugaauagu auaacaauau gcuaaauguu guuauaguau ccacc                       45


<210>  38
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38
ggugaagagg agaacaauau gcuaaauguu guucucgucu ccacc                       45


<210>  39
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacc            55


<210>  40
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n is a 2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n is a 2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is a 2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is a 2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is a 2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  n is a 2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  n is a 2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  n is a 2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (37)..(41)
<223>  n is a 2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (43)..(49)
<223>  n is a 2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  n is a 2'-O-methyl nucleotide

<220>
<221>  misc_feature
<222>  (54)..(55)
<223>  n is a 2'-O-methyl nucleotide

<400>  40
nnngnngaga agaggagaan aanangnnaa angnngnnnn ngnnnnnnng anann            55


<210>  41
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210>  42
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42
guggaauagu auaacaauau gcuaaauguu guuauaguau cccac                       45


<210>  43
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43
ggugucgaga auaguauaac aauaugcuaa auguuguuau aguauccucg acacc            55


<210>  44
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210>  45
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45
ggguggaaua guauaccauu cgugguauag uaucccaccu                             40


<210>  46
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46
guggguggaa uaguauacca uucgugguau aguaucccac cuac                        44


<210>  47
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47
uggguggaau aguauaccau ucgugguaua guaucccacc ua                          42


<210>  48
<211>  38
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48
gguggaauag uauaccauuc gugguauagu aucccacc                               38


<210>  49
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49
guggaauagu auaccauucg ugguauagua ucccac                                 36


<210>  50
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50
acatgaggat cacccatgt                                                    19


<210>  51
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (46)..(47)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (48)..(50)
<223>  2'-O-methylcytidine

<400>  51
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuuccc                  50


<210>  52
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  Beta-D-homoDNA-cytidine

<220>
<221>  modified_base
<222>  (46)..(47)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (48)..(50)
<223>  2'-O-methylcytidine

<400>  52
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuuccc                  50


<210>  53
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  Beta-D-homoDNA-cytidine

<220>
<221>  modified_base
<222>  (46)..(47)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (48)..(50)
<223>  2'-O-methylcytidine

<400>  53
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuuccc                  50


<210>  54
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (9)..(10)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (43)..(43)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (44)..(44)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (46)..(47)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (48)..(50)
<223>  2'-O-methylcytidine

<400>  54
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuuccc                  50


<210>  55
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (9)..(10)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  Beta-D-homoDNA-cytidine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (43)..(43)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (44)..(44)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (46)..(47)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (48)..(50)
<223>  2'-O-methylcytidine

<400>  55
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuuccc                  50


<210>  56
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (9)..(10)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (29)..(29)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (30)..(30)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (37)..(37)
<223>  Beta-D-homoDNA-cytidine

<220>
<221>  modified_base
<222>  (39)..(39)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (40)..(40)
<223>  2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (43)..(43)
<223>  2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (44)..(44)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (46)..(47)
<223>  2'-O-methyluridine

<220>
<221>  modified_base
<222>  (48)..(50)
<223>  2'-O-methylcytidine

<400>  56
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuuccc                  50


<210>  57
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  57

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210>  59
<211>  13
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  59

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  60
<211>  16
<212>  PRT
<213>  Drosophila Antennapedia

<400>  60

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  61
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61
acagtatcca tttattatgt aatgcttctt ag                                     32


<210>  62
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62
tgaaaggagc gccttctaga ac                                                22


<210>  63
<211>  88
<212>  RNA
<213>  Homo sapiens

<400>  63
cagaguguua cucagaauug ggaaauccag cuagcggcag uauucuguac aguagacaca       60

agaauuaugu acgccuuuua ucaaagac                                          88


<210>  64
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64
cauaauucuu gugucuacug uacagaauac ugccgccagc uggauuuccc                  50


