                         SEQUENCE LISTING

<110>  BRISTOL-MYERS SQUIBB COMPANY
 
<120>  ANTIBODIES AGAINST IL-7R ALPHA SUBUNIT AND USES THEREOF

<130>  4521.001PC02/C-K/DKC

<150>  US 62/795,378
<151>  2019-01-22

<150>  US 62/868,791
<151>  2019-06-28

<160>  265   

<170>  PatentIn version 3.5

<210>  1
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Val Ser Val Phe Gly Ala 
    290                 295             


<210>  2
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Leu Ser Leu Ser 
225                 230                 235                 240 


Tyr Gly Pro Val Ser Pro Ile Ile Arg Gln Glu Leu 
                245                 250         


<210>  3
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Val Ser Val Phe Gly Ala 
    290                 295             


<210>  4
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Leu Ser Leu Ser 
225                 230                 235                 240 


Tyr Gly Pro Val Ser Pro Ile Ile Arg Arg Leu Trp Asn Ile Phe Val 
                245                 250                 255     


Arg Asn Gln Glu Lys 
            260     


<210>  5
<211>  4643
<212>  DNA
<213>  Homo sapiens

<400>  5
gtggttagat aagtataaag ccctagatct aagcttctct gtcttcctcc ctccctccct       60

tcctcttact ctcattcatt tcatacacac tggctcacac atctactctc tctctctatc      120

tctctcagaa tgacaattct aggtacaact tttggcatgg ttttttcttt acttcaagtc      180

gtttctggag aaagtggcta tgctcaaaat ggagacttgg aagatgcaga actggatgac      240

tactcattct catgctatag ccagttggaa gtgaatggat cgcagcactc actgacctgt      300

gcttttgagg acccagatgt caacatcacc aatctggaat ttgaaatatg tggggccctc      360

gtggaggtaa agtgcctgaa tttcaggaaa ctacaagaga tatatttcat cgagacaaag      420

aaattcttac tgattggaaa gagcaatata tgtgtgaagg ttggagaaaa gagtctaacc      480

tgcaaaaaaa tagacctaac cactatagtt aaacctgagg ctccttttga cctgagtgtc      540

gtctatcggg aaggagccaa tgactttgtg gtgacattta atacatcaca cttgcaaaag      600

aagtatgtaa aagttttaat gcacgatgta gcttaccgcc aggaaaagga tgaaaacaaa      660

tggacgcatg tgaatttatc cagcacaaag ctgacactcc tgcagagaaa gctccaaccg      720

gcagcaatgt atgagattaa agttcgatcc atccctgatc actattttaa aggcttctgg      780

agtgaatgga gtccaagtta ttacttcaga actccagaga tcaataatag ctcaggggag      840

atggatccta tcttactaac catcagcatt ttgagttttt tctctgtcgc tctgttggtc      900

atcttggcct gtgtgttatg gaaaaaaagg attaagccta tcgtatggcc cagtctcccc      960

gatcataaga agactctgga acatctttgt aagaaaccaa gaaaaaattt aaatgtgagt     1020

ttcaatcctg aaagtttcct ggactgccag attcataggg tggatgacat tcaagctaga     1080

gatgaagtgg aaggttttct gcaagatacg tttcctcagc aactagaaga atctgagaag     1140

cagaggcttg gaggggatgt gcagagcccc aactgcccat ctgaggatgt agtcatcact     1200

ccagaaagct ttggaagaga ttcatccctc acatgcctgg ctgggaatgt cagtgcatgt     1260

gacgccccta ttctctcctc ttccaggtcc ctagactgca gggagagtgg caagaatggg     1320

cctcatgtgt accaggacct cctgcttagc cttgggacta caaacagcac gctgccccct     1380

ccattttctc tccaatctgg aatcctgaca ttgaacccag ttgctcaggg tcagcccatt     1440

cttacttccc tgggatcaaa tcaagaagaa gcatatgtca ccatgtccag cttctaccaa     1500

aaccagtgaa gtgtaagaaa cccagactga acttaccgtg agcgacaaag atgatttaaa     1560

agggaagtct agagttccta gtctccctca cagcacagag aagacaaaat tagcaaaacc     1620

ccactacaca gtctgcaaga ttctgaaaca ttgctttgac cactcttcct gagttcagtg     1680

gcactcaaca tgagtcaaga gcatcctgct tctaccatgt ggatttggtc acaaggttta     1740

aggtgaccca atgattcagc tatttaaaaa aaaaagagga aagaatgaaa gagtaaagga     1800

aatgattgag gagtgaggaa ggcaggaaga gagcatgaga ggaaagaaag aaaggaaaat     1860

aaaaaatgat agttgccatt attaggattt aatatatatc cagtgctttg caagtgctct     1920

gcgcaccttg tctcactcca tcctgacaat aatcctggga ggtgtgtgca attactacga     1980

ctactctctt ttttatagat cattaaattc agaactaagg agttaagtaa cttgtccaag     2040

ttgttcacac agtgaaggga ggggccaaga tatgatggct gggagtctaa ttgcagttcc     2100

ctgagccatg tgcctttctc ttcactgagg actgccccat tcttgagtgc caaacgtcac     2160

tagtaacagg gtgtgcctag ataatttatg atccaaactg agtcagtttg gaaagtgaaa     2220

gggaaactta catataatcc ctccgggaca atgagcaaaa actaggactg tccccagaca     2280

aatgtgaaca tacatatcat cacttaaatt aaaatggcta tgagaaagaa agagggggag     2340

aaacagtctt gcgggtgtga agtcccatga ccagccatgt caaaagaagg taaagaagtc     2400

aagaaaaagc catgaagccc atttggtttc atttttctga aaataggctc aagagggaat     2460

aaattagaaa ctcacaattt ctcttgtttg ttaccaagac agtgattctc ttgctgctac     2520

cacccaactg catccgtcca tgatctcaga ggaaactgtc gctgaccctg gacatgggta     2580

cgtttgacga gtgagaggag gcatgacccc tcccatgtgt atagacacta ccccaaccta     2640

aattcatccc taaattgtcc caagttctcc agcaatagag gctgccacaa acttcaggga     2700

gaaagagtta caagtacatg caatgagtga actgactgtg gctacaatct tgaagatata     2760

cggaagagac gtattattaa tgcttgacat atatcatctt gcctttcttg gtctagactg     2820

acttctaatg actaactcaa agtcaaggca actgagtaat gtcagctcag caaagtgcag     2880

caaacccatc tcccacaggc ctccaaaccc tggctgttca cagaaccaca aagggcagat     2940

gctgcacaga aaactagaga aggggtcata ggttcatggt tttgtttgag atttgttgct     3000

actgtttttc tgttttgaat tttcttcttt gttctgtttt tactttattt agggggacta     3060

ggtgtttctg atattttagt tttcttgttt gttttgtttt gtgttgtctg tgaatggggt     3120

tttaactgtg gatgaatgga ccttatctgt tggcttaaag gactggtaag atcagaccat     3180

cttattcttc aggtgaatgt tttactttcc aaagtgctct cctctgcacc agcagtaata     3240

aatacaatgc cataatccct taggtttgcc tagtgctttt gcaattttca aagcacttcc     3300

ataagcattc cttccacctc cttgataggc atttatggaa agcctgctac atgtcaatca     3360

tactgttagg cacaggggac ctaaagacac ataaaaggat ggcattctgc ctcataaatt     3420

gcaaaaccta atgaaagtga ctgcttggta aacaaattat tattatatta taaaatgcta     3480

taaaagagcc atattgaaag tgccctgttg gagacagggc aaatgccaca aaaatgatgt     3540

aaatttacat ggaggaaaag tagaatctgc ctggtttgta ggcagcagaa gacatttttc     3600

atcagtgggc aggtgttctt taccttttgt agaaatggga gtcaagtctc aaataggagg     3660

ctccacaaaa tctcatgcca ggtctctgat accttattca cagaagttct ttgaagtatt     3720

tattgttatt ttctttgact tatgggaaaa ctgggacaca ggaagacagg taaattaccc     3780

aacctcacac gttaagtcag aactgggagc cataattttg tatccctggt ataaatagac     3840

aatctcttga agaaatgaag agatgaccat agaaaaacat cgagatatct ccagctctaa     3900

aatcctttgt ttcaatgttg tttggcatat gttatctttg gaatttagtg tctgagcctc     3960

tgtctgttac tgtagtattt aaaatgcatg tattataatc atataatcat aactgctgtt     4020

aattcttgat tatataccta gggacaatgt gtaatgtaag attactaatt ggttctgccc     4080

aatctccttt cagattttat taggaaaaaa aaataaacct cctgatcgga gacaatgtat     4140

taatcagaag tgtaaactgc cagttctata tagcatgaaa tgaaaagaca gctaatttgg     4200

tccaacaaac atgactgggt ctagggcacc caggctgatt cagctgattt cctaccagcc     4260

tttgcctctt ccttcaatgt ggtttccatg ggaatttgct tcagaaaagc caagtatggg     4320

ctgttcagag gtgcacacct gcattttctt agctcttcta gaggggctaa gagacttggt     4380

acgggccagg aagaatatgt ggcagagctc ctggaaatga tgcagattag gtggcatttt     4440

tgtcagctct gtggtttatt gttgggacta ttctttaaaa tatccattgt tcactacagt     4500

gaagatctct gatttaaccg tgtactatcc acatgcatta caaacatttc gcagagctgc     4560

ttagtatata agcgtacaat gtatgtaata accatctcat atttaattaa atggtataga     4620

agaacaaaaa aaaaaaaaaa aaa                                             4643


<210>  6
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu Asp 
1               5                   10                  15      


Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser Gln 
            20                  25                  30          


His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val Asn Thr Thr Asn 
        35                  40                  45              


Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val Lys Cys Leu Asn 
    50                  55                  60                  


Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe Leu 
65                  70                  75                  80  


Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly Glu Lys Ser Leu 
                85                  90                  95      


Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys Pro Glu Ala Pro 
            100                 105                 110         


Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn Asp Phe Val Val 
        115                 120                 125             


Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu Met 
    130                 135                 140                 


His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr His 
145                 150                 155                 160 


Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu Gln 
                165                 170                 175     


Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr 
            180                 185                 190         


Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg Thr 
        195                 200                 205             


Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp 
    210                 215                 


<210>  7
<211>  459
<212>  PRT
<213>  Macaca fascicularis

<400>  7

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Ser Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Gly Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Met His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Asn Leu Gln Pro Glu Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Pro Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Leu Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Lys 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Ser Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Ile Thr Pro Glu Ser Phe Glu Arg Asp Ser Ser Leu Arg 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope 1

<400>  8

Ser Gln Leu Glu Val Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope 2

<400>  9

Phe Ile Glu Thr Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys 
1               5                   10                  15      


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope 3

<400>  10

Val Lys Val Gly Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr 
1               5                   10                  15      


Thr 
    


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope 4

<400>  11

Gln Lys Lys Tyr Val Lys Val Leu Met His Asp Val Ala Tyr 
1               5                   10                  


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope 5

<400>  12

Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr Phe Lys Gly Phe 
1               5                   10                  15      


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1

<400>  13

Asp His Ala Met His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2

<400>  14

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3

<400>  15

Asp Glu Tyr Ser Arg Gly Tyr Tyr Val Leu Asp Val 
1               5                   10          


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR1

<400>  16

Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR2

<400>  17

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain CDR3

<400>  18

Gln Gln Phe Asn Ser Tyr Pro Leu Trp Ile Thr 
1               5                   10      


<210>  19
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable Region (VH)

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp His 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Phe Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Glu Tyr Ser Arg Gly Tyr Tyr Val Leu Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  20
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain Variable region (VL)

<400>  20

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Trp Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 


<210>  21
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp His 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Phe Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Glu Tyr Ser Arg Gly Tyr Tyr Val Leu Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
225                 230                 235                 240 


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  22
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<400>  22

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Trp Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  23
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  24
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  25
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1.1f Constant Region

<400>  25

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  26
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1.3f Constant Region

<400>  26

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  27
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  27

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LSPGK (C-terminal end of heavy chain)

<400>  28

Leu Ser Pro Gly Lys 
1               5   


<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LSPG (C-terminal end of heavy chain)

<400>  29

Leu Ser Pro Gly 
1               


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  30

Pro Val Gly Val Val 
1               5   


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (18B1)

<400>  31

Gly Phe Thr Phe Asp Asp His Ala Met His 
1               5                   10  


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (F27Y)

<400>  32

Gly Tyr Thr Phe Asp Asp His Ala Met His 
1               5                   10  


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (T28P)

<400>  33

Gly Phe Pro Phe Asp Asp His Ala Met His 
1               5                   10  


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (T28A)

<400>  34

Gly Phe Ala Phe Asp Asp His Ala Met His 
1               5                   10  


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (T28V)

<400>  35

Gly Phe Val Phe Asp Asp His Ala Met His 
1               5                   10  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (T28L)

<400>  36

Gly Phe Leu Phe Asp Asp His Ala Met His 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (T28I)

<400>  37

Gly Phe Ile Phe Asp Asp His Ala Met His 
1               5                   10  


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (T28M)

<400>  38

Gly Phe Met Phe Asp Asp His Ala Met His 
1               5                   10  


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (T28H)

<400>  39

Gly Phe His Phe Asp Asp His Ala Met His 
1               5                   10  


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (T28F)

<400>  40

Gly Phe Phe Phe Asp Asp His Ala Met His 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (T28Y)

<400>  41

Gly Phe Tyr Phe Asp Asp His Ala Met His 
1               5                   10  


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (T28N)

<400>  42

Gly Phe Asn Phe Asp Asp His Ala Met His 
1               5                   10  


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (T28D)

<400>  43

Gly Phe Asp Phe Asp Asp His Ala Met His 
1               5                   10  


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (T28E)

<400>  44

Gly Phe Glu Phe Asp Asp His Ala Met His 
1               5                   10  


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (T28Q)

<400>  45

Gly Phe Gln Phe Asp Asp His Ala Met His 
1               5                   10  


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1 (M34L)

<400>  46

Gly Phe Thr Phe Asp Asp His Ala Leu His 
1               5                   10  


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (S52T)

<400>  47

Gly Ile Thr Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (N53H)

<400>  48

Gly Ile Ser Trp His Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (I57V)

<400>  49

Gly Ile Ser Trp Asn Ser Arg Gly Val Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (A60G)

<400>  50

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (A60S)

<400>  51

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ser Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (A60T)

<400>  52

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (A60V)

<400>  53

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (A60L)

<400>  54

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Leu Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (A60I)

<400>  55

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ile Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (A60R)

<400>  56

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (A60H)

<400>  57

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr His Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (A60N)

<400>  58

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Asn Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (D61P)

<400>  59

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Pro Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  60
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (D61T)

<400>  60

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Thr Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  61
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (D61N)

<400>  61

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asn Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  62
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (D61E)

<400>  62

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  63
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (D61Q)

<400>  63

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Gln Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  64
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (D61S)

<400>  64

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Ser Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  65
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (D61H)

<400>  65

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala His Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (S62P)

<400>  66

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Pro Val Lys 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (S62G)

<400>  67

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Gly Val Lys 
1               5                   10                  15      


Gly 
    


<210>  68
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (S62A)

<400>  68

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  69
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (S62T)

<400>  69

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  70
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (S62V)

<400>  70

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Val Val Lys 
1               5                   10                  15      


Gly 
    


<210>  71
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (S62R)

<400>  71

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Arg Val Lys 
1               5                   10                  15      


Gly 
    


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (S62H)

<400>  72

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp His Val Lys 
1               5                   10                  15      


Gly 
    


<210>  73
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (S62F)

<400>  73

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Phe Val Lys 
1               5                   10                  15      


Gly 
    


<210>  74
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (S62Y)

<400>  74

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Tyr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  75
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (S62N)

<400>  75

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Asn Val Lys 
1               5                   10                  15      


Gly 
    


<210>  76
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (S62D)

<400>  76

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Asp Val Lys 
1               5                   10                  15      


Gly 
    


<210>  77
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (S62E)

<400>  77

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Glu Val Lys 
1               5                   10                  15      


Gly 
    


<210>  78
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (V63I)

<400>  78

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Ile Lys 
1               5                   10                  15      


Gly 
    


<210>  79
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (K64A)

<400>  79

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Ala 
1               5                   10                  15      


Gly 
    


<210>  80
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (K64S)

<400>  80

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Ser 
1               5                   10                  15      


Gly 
    


<210>  81
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (K64T)

<400>  81

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Thr 
1               5                   10                  15      


Gly 
    


<210>  82
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (K64V)

<400>  82

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Val 
1               5                   10                  15      


Gly 
    


<210>  83
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (K64L)

<400>  83

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Leu 
1               5                   10                  15      


Gly 
    


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (K64I)

<400>  84

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Ile 
1               5                   10                  15      


Gly 
    


<210>  85
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (K64M)

<400>  85

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Met 
1               5                   10                  15      


Gly 
    


<210>  86
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (K64R)

<400>  86

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (K64H)

<400>  87

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val His 
1               5                   10                  15      


Gly 
    


<210>  88
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (K64F)

<400>  88

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Phe 
1               5                   10                  15      


Gly 
    


<210>  89
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (K64Y)

<400>  89

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Tyr 
1               5                   10                  15      


Gly 
    


<210>  90
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (K64N)

<400>  90

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Asn 
1               5                   10                  15      


Gly 
    


<210>  91
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (K64D)

<400>  91

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Asp 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (K64E)

<400>  92

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  93
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (K64Q)

<400>  93

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Gln 
1               5                   10                  15      


Gly 
    


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (G65H)

<400>  94

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


His 
    


<210>  95
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (G65D)

<400>  95

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210>  96
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2 (G65Q)

<400>  96

Gly Ile Ser Trp Asn Ser Arg Gly Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gln 
    


<210>  97
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (S98T)

<400>  97

Asp Glu Tyr Thr Arg Gly Tyr Tyr Val Leu Asp Val 
1               5                   10          


<210>  98
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (S98N)

<400>  98

Asp Glu Tyr Asn Arg Gly Tyr Tyr Val Leu Asp Val 
1               5                   10          


<210>  99
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (S98D)

<400>  99

Asp Glu Tyr Asp Arg Gly Tyr Tyr Val Leu Asp Val 
1               5                   10          


<210>  100
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (S98E)

<400>  100

Asp Glu Tyr Glu Arg Gly Tyr Tyr Val Leu Asp Val 
1               5                   10          


<210>  101
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (R99L)

<400>  101

Asp Glu Tyr Ser Leu Gly Tyr Tyr Val Leu Asp Val 
1               5                   10          


<210>  102
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (R99M)

<400>  102

Asp Glu Tyr Ser Met Gly Tyr Tyr Val Leu Asp Val 
1               5                   10          


<210>  103
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (R99S)

<400>  103

Asp Glu Tyr Ser Ser Gly Tyr Tyr Val Leu Asp Val 
1               5                   10          


<210>  104
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V100cG)

<400>  104

Asp Glu Tyr Ser Arg Gly Tyr Tyr Gly Leu Asp Val 
1               5                   10          


<210>  105
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V100cA)

<400>  105

Asp Glu Tyr Ser Arg Gly Tyr Tyr Ala Leu Asp Val 
1               5                   10          


<210>  106
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V100cS)

<400>  106

Asp Glu Tyr Ser Arg Gly Tyr Tyr Ser Leu Asp Val 
1               5                   10          


<210>  107
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V100cT)

<400>  107

Asp Glu Tyr Ser Arg Gly Tyr Tyr Thr Leu Asp Val 
1               5                   10          


<210>  108
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V100cM)

<400>  108

Asp Glu Tyr Ser Arg Gly Tyr Tyr Met Leu Asp Val 
1               5                   10          


<210>  109
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V100cN)

<400>  109

Asp Glu Tyr Ser Arg Gly Tyr Tyr Asn Leu Asp Val 
1               5                   10          


<210>  110
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V100cE)

<400>  110

Asp Glu Tyr Ser Arg Gly Tyr Tyr Glu Leu Asp Val 
1               5                   10          


<210>  111
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V100cQ)

<400>  111

Asp Glu Tyr Ser Arg Gly Tyr Tyr Gln Leu Asp Val 
1               5                   10          


<210>  112
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V102A)

<400>  112

Asp Glu Tyr Ser Arg Gly Tyr Tyr Val Leu Asp Ala 
1               5                   10          


<210>  113
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V102S)

<400>  113

Asp Glu Tyr Ser Arg Gly Tyr Tyr Val Leu Asp Ser 
1               5                   10          


<210>  114
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V102T)

<400>  114

Asp Glu Tyr Ser Arg Gly Tyr Tyr Val Leu Asp Thr 
1               5                   10          


<210>  115
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V102R)

<400>  115

Asp Glu Tyr Ser Arg Gly Tyr Tyr Val Leu Asp Arg 
1               5                   10          


<210>  116
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V102H)

<400>  116

Asp Glu Tyr Ser Arg Gly Tyr Tyr Val Leu Asp His 
1               5                   10          


<210>  117
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V102Y)

<400>  117

Asp Glu Tyr Ser Arg Gly Tyr Tyr Val Leu Asp Tyr 
1               5                   10          


<210>  118
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V102W)

<400>  118

Asp Glu Tyr Ser Arg Gly Tyr Tyr Val Leu Asp Trp 
1               5                   10          


<210>  119
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V102N)

<400>  119

Asp Glu Tyr Ser Arg Gly Tyr Tyr Val Leu Asp Asn 
1               5                   10          


<210>  120
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V102E)

<400>  120

Asp Glu Tyr Ser Arg Gly Tyr Tyr Val Leu Asp Glu 
1               5                   10          


<210>  121
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V102Q)

<400>  121

Asp Glu Tyr Ser Arg Gly Tyr Tyr Val Leu Asp Gln 
1               5                   10          


<210>  122
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3 (V102M)

<400>  122

Asp Glu Tyr Ser Arg Gly Tyr Tyr Val Leu Asp Met 
1               5                   10          


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (R24S)

<400>  123

Ser Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  124
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (R24T)

<400>  124

Thr Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  125
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (R24V)

<400>  125

Val Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  126
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (R24K)

<400>  126

Lys Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  127
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (R24H)

<400>  127

His Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  128
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (R24Y)

<400>  128

Tyr Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  129
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (R24I)

<400>  129

Ile Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  130
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (A25S)

<400>  130

Arg Ser Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  131
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (A25T)

<400>  131

Arg Thr Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (A25V)

<400>  132

Arg Val Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  133
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S26P)

<400>  133

Arg Ala Pro Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  134
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S26G)

<400>  134

Arg Ala Gly Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  135
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S26A)

<400>  135

Arg Ala Ala Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  136
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S26T)

<400>  136

Arg Ala Thr Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  137
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S26V)

<400>  137

Arg Ala Val Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  138
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S26L)

<400>  138

Arg Ala Leu Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  139
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S26I)

<400>  139

Arg Ala Ile Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  140
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S26M)

<400>  140

Arg Ala Met Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S26K)

<400>  141

Arg Ala Lys Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  142
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S26R)

<400>  142

Arg Ala Arg Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  143
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S26H)

<400>  143

Arg Ala His Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  144
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S26N)

<400>  144

Arg Ala Asn Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  145
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S26E)

<400>  145

Arg Ala Glu Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  146
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S26Q)

<400>  146

Arg Ala Gln Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (Q27P)

<400>  147

Arg Ala Ser Pro Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  148
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (Q27G)

<400>  148

Arg Ala Ser Gly Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  149
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (Q27A)

<400>  149

Arg Ala Ser Ala Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  150
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (Q27S)

<400>  150

Arg Ala Ser Ser Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  151
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (Q27T)

<400>  151

Arg Ala Ser Thr Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  152
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (Q27V)

<400>  152

Arg Ala Ser Val Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  153
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (Q27L)

<400>  153

Arg Ala Ser Leu Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  154
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (Q27I)

<400>  154

Arg Ala Ser Ile Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  155
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (Q27M)

<400>  155

Arg Ala Ser Met Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  156
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (Q27H)

<400>  156

Arg Ala Ser His Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  157
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (Q27F)

<400>  157

Arg Ala Ser Phe Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  158
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (Q27Y)

<400>  158

Arg Ala Ser Tyr Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  159
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (Q27N)

<400>  159

Arg Ala Ser Asn Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  160
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (Q27D)

<400>  160

Arg Ala Ser Asp Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  161
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (Q27E)

<400>  161

Arg Ala Ser Glu Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  162
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (G28P)

<400>  162

Arg Ala Ser Gln Pro Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  163
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (G28A)

<400>  163

Arg Ala Ser Gln Ala Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  164
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (G28S)

<400>  164

Arg Ala Ser Gln Ser Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  165
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (G28T)

<400>  165

Arg Ala Ser Gln Thr Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  166
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (G28H)

<400>  166

Arg Ala Ser Gln His Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  167
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (G28E)

<400>  167

Arg Ala Ser Gln Glu Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  168
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (G28Q)

<400>  168

Arg Ala Ser Gln Gln Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  169
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (G28M)

<400>  169

Arg Ala Ser Gln Met Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  170
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (G28N)

<400>  170

Arg Ala Ser Gln Asn Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  171
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (G28D)

<400>  171

Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  172
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (I29P)

<400>  172

Arg Ala Ser Gln Gly Pro Ser Ser Ala Leu Ala 
1               5                   10      


<210>  173
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (I29G)

<400>  173

Arg Ala Ser Gln Gly Gly Ser Ser Ala Leu Ala 
1               5                   10      


<210>  174
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (I29A)

<400>  174

Arg Ala Ser Gln Gly Ala Ser Ser Ala Leu Ala 
1               5                   10      


<210>  175
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (I29S)

<400>  175

Arg Ala Ser Gln Gly Ser Ser Ser Ala Leu Ala 
1               5                   10      


<210>  176
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (I29T)

<400>  176

Arg Ala Ser Gln Gly Thr Ser Ser Ala Leu Ala 
1               5                   10      


<210>  177
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (I29V)

<400>  177

Arg Ala Ser Gln Gly Val Ser Ser Ala Leu Ala 
1               5                   10      


<210>  178
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (I29L)

<400>  178

Arg Ala Ser Gln Gly Leu Ser Ser Ala Leu Ala 
1               5                   10      


<210>  179
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (I29N)

<400>  179

Arg Ala Ser Gln Gly Asn Ser Ser Ala Leu Ala 
1               5                   10      


<210>  180
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S30T)

<400>  180

Arg Ala Ser Gln Gly Ile Thr Ser Ala Leu Ala 
1               5                   10      


<210>  181
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S30V)

<400>  181

Arg Ala Ser Gln Gly Ile Val Ser Ala Leu Ala 
1               5                   10      


<210>  182
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S30L)

<400>  182

Arg Ala Ser Gln Gly Ile Leu Ser Ala Leu Ala 
1               5                   10      


<210>  183
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S30I)

<400>  183

Arg Ala Ser Gln Gly Ile Ile Ser Ala Leu Ala 
1               5                   10      


<210>  184
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S30M)

<400>  184

Arg Ala Ser Gln Gly Ile Met Ser Ala Leu Ala 
1               5                   10      


<210>  185
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S30M)

<400>  185

Arg Ala Ser Gln Gly Ile His Ser Ala Leu Ala 
1               5                   10      


<210>  186
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S30F)

<400>  186

Arg Ala Ser Gln Gly Ile Phe Ser Ala Leu Ala 
1               5                   10      


<210>  187
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S30Y)

<400>  187

Arg Ala Ser Gln Gly Ile Tyr Ser Ala Leu Ala 
1               5                   10      


<210>  188
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S30N)

<400>  188

Arg Ala Ser Gln Gly Ile Asn Ser Ala Leu Ala 
1               5                   10      


<210>  189
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S30D)

<400>  189

Arg Ala Ser Gln Gly Ile Asp Ser Ala Leu Ala 
1               5                   10      


<210>  190
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S30E)

<400>  190

Arg Ala Ser Gln Gly Ile Glu Ser Ala Leu Ala 
1               5                   10      


<210>  191
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (S30Q)

<400>  191

Arg Ala Ser Gln Gly Ile Gln Ser Ala Leu Ala 
1               5                   10      


<210>  192
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (A32P)

<400>  192

Arg Ala Ser Gln Gly Ile Ser Ser Pro Leu Ala 
1               5                   10      


<210>  193
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (L33A)

<400>  193

Arg Ala Ser Gln Gly Ile Ser Ser Ala Ala Ala 
1               5                   10      


<210>  194
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR1 (L33V)

<400>  194

Arg Ala Ser Gln Gly Ile Ser Ser Ala Val Ala 
1               5                   10      


<210>  195
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (A51G)

<400>  195

Asp Gly Ser Ser Leu Glu Ser 
1               5           


<210>  196
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (A51S)

<400>  196

Asp Ser Ser Ser Leu Glu Ser 
1               5           


<210>  197
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (A51M)

<400>  197

Asp Met Ser Ser Leu Glu Ser 
1               5           


<210>  198
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (A51H)

<400>  198

Asp His Ser Ser Leu Glu Ser 
1               5           


<210>  199
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (A51N)

<400>  199

Asp Asn Ser Ser Leu Glu Ser 
1               5           


<210>  200
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (A51D)

<400>  200

Asp Asp Ser Ser Leu Glu Ser 
1               5           


<210>  201
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (A51E)

<400>  201

Asp Glu Ser Ser Leu Glu Ser 
1               5           


<210>  202
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (A51Q)

<400>  202

Asp Gln Ser Ser Leu Glu Ser 
1               5           


<210>  203
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S52G)

<400>  203

Asp Ala Gly Ser Leu Glu Ser 
1               5           


<210>  204
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S52A)

<400>  204

Asp Ala Ala Ser Leu Glu Ser 
1               5           


<210>  205
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S52T)

<400>  205

Asp Ala Thr Ser Leu Glu Ser 
1               5           


<210>  206
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S52V)

<400>  206

Asp Ala Val Ser Leu Glu Ser 
1               5           


<210>  207
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S52M)

<400>  207

Asp Ala Met Ser Leu Glu Ser 
1               5           


<210>  208
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S52H)

<400>  208

Asp Ala His Ser Leu Glu Ser 
1               5           


<210>  209
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S52F)

<400>  209

Asp Ala Phe Ser Leu Glu Ser 
1               5           


<210>  210
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S52Y)

<400>  210

Asp Ala Tyr Ser Leu Glu Ser 
1               5           


<210>  211
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S52N)

<400>  211

Asp Ala Asn Ser Leu Glu Ser 
1               5           


<210>  212
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S52D)

<400>  212

Asp Ala Asp Ser Leu Glu Ser 
1               5           


<210>  213
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S52E)

<400>  213

Asp Ala Glu Ser Leu Glu Ser 
1               5           


<210>  214
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S52Q)

<400>  214

Asp Ala Gln Ser Leu Glu Ser 
1               5           


<210>  215
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S53A)

<400>  215

Asp Ala Ser Ala Leu Glu Ser 
1               5           


<210>  216
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S53F)

<400>  216

Asp Ala Ser Phe Leu Glu Ser 
1               5           


<210>  217
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S53Y)

<400>  217

Asp Ala Ser Tyr Leu Glu Ser 
1               5           


<210>  218
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S53W)

<400>  218

Asp Ala Ser Trp Leu Glu Ser 
1               5           


<210>  219
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S53N)

<400>  219

Asp Ala Ser Asn Leu Glu Ser 
1               5           


<210>  220
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S53D)

<400>  220

Asp Ala Ser Asp Leu Glu Ser 
1               5           


<210>  221
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S53E)

<400>  221

Asp Ala Ser Glu Leu Glu Ser 
1               5           


<210>  222
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S53L)

<400>  222

Asp Ala Ser Leu Leu Glu Ser 
1               5           


<210>  223
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (L54P)

<400>  223

Asp Ala Ser Ser Pro Glu Ser 
1               5           


<210>  224
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (L54S)

<400>  224

Asp Ala Ser Ser Ser Glu Ser 
1               5           


<210>  225
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (L54T)

<400>  225

Asp Ala Ser Ser Thr Glu Ser 
1               5           


<210>  226
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (L54K)

<400>  226

Asp Ala Ser Ser Lys Glu Ser 
1               5           


<210>  227
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (L54H)

<400>  227

Asp Ala Ser Ser His Glu Ser 
1               5           


<210>  228
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (L54N)

<400>  228

Asp Ala Ser Ser Asn Glu Ser 
1               5           


<210>  229
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (E55D)

<400>  229

Asp Ala Ser Ser Leu Asp Ser 
1               5           


<210>  230
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (E55Q)

<400>  230

Asp Ala Ser Ser Leu Gln Ser 
1               5           


<210>  231
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S56G)

<400>  231

Asp Ala Ser Ser Leu Glu Gly 
1               5           


<210>  232
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S56T)

<400>  232

Asp Ala Ser Ser Leu Glu Thr 
1               5           


<210>  233
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S56N)

<400>  233

Asp Ala Ser Ser Leu Glu Asn 
1               5           


<210>  234
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S56D)

<400>  234

Asp Ala Ser Ser Leu Glu Asp 
1               5           


<210>  235
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S56Q)

<400>  235

Asp Ala Ser Ser Leu Glu Gln 
1               5           


<210>  236
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S56P)

<400>  236

Asp Ala Ser Ser Leu Glu Pro 
1               5           


<210>  237
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2 (S56E)

<400>  237

Asp Ala Ser Ser Leu Glu Glu 
1               5           


<210>  238
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (Q89M)

<400>  238

Met Gln Phe Asn Ser Tyr Pro Leu Trp Ile Thr 
1               5                   10      


<210>  239
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (Q90G)

<400>  239

Gln Gly Phe Asn Ser Tyr Pro Leu Trp Ile Thr 
1               5                   10      


<210>  240
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (Q90A)

<400>  240

Gln Ala Phe Asn Ser Tyr Pro Leu Trp Ile Thr 
1               5                   10      


<210>  241
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (Q90D)

<400>  241

Gln Asp Phe Asn Ser Tyr Pro Leu Trp Ile Thr 
1               5                   10      


<210>  242
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (Q90E)

<400>  242

Gln Glu Phe Asn Ser Tyr Pro Leu Trp Ile Thr 
1               5                   10      


<210>  243
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (N92E)

<400>  243

Gln Gln Phe Glu Ser Tyr Pro Leu Trp Ile Thr 
1               5                   10      


<210>  244
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (S93P)

<400>  244

Gln Gln Phe Asn Pro Tyr Pro Leu Trp Ile Thr 
1               5                   10      


<210>  245
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (S93A)

<400>  245

Gln Gln Phe Asn Ala Tyr Pro Leu Trp Ile Thr 
1               5                   10      


<210>  246
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (W95bT)

<400>  246

Gln Gln Phe Asn Ser Tyr Pro Leu Thr Ile Thr 
1               5                   10      


<210>  247
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (W95bI)

<400>  247

Gln Gln Phe Asn Ser Tyr Pro Leu Ile Ile Thr 
1               5                   10      


<210>  248
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (W95bM)

<400>  248

Gln Gln Phe Asn Ser Tyr Pro Leu Met Ile Thr 
1               5                   10      


<210>  249
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (W95bK)

<400>  249

Gln Gln Phe Asn Ser Tyr Pro Leu Lys Ile Thr 
1               5                   10      


<210>  250
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (W95bN)

<400>  250

Gln Gln Phe Asn Ser Tyr Pro Leu Asn Ile Thr 
1               5                   10      


<210>  251
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (W95bE)

<400>  251

Gln Gln Phe Asn Ser Tyr Pro Leu Glu Ile Thr 
1               5                   10      


<210>  252
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (W95bQ)

<400>  252

Gln Gln Phe Asn Ser Tyr Pro Leu Gln Ile Thr 
1               5                   10      


<210>  253
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (I96L)

<400>  253

Gln Gln Phe Asn Ser Tyr Pro Leu Trp Leu Thr 
1               5                   10      


<210>  254
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (T97M)

<400>  254

Gln Gln Phe Asn Ser Tyr Pro Leu Trp Ile Met 
1               5                   10      


<210>  255
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (T97K)

<400>  255

Gln Gln Phe Asn Ser Tyr Pro Leu Trp Ile Lys 
1               5                   10      


<210>  256
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (T97H)

<400>  256

Gln Gln Phe Asn Ser Tyr Pro Leu Trp Ile His 
1               5                   10      


<210>  257
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (T97Y)

<400>  257

Gln Gln Phe Asn Ser Tyr Pro Leu Trp Ile Tyr 
1               5                   10      


<210>  258
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (T97E)

<400>  258

Gln Gln Phe Asn Ser Tyr Pro Leu Trp Ile Glu 
1               5                   10      


<210>  259
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3 (T97Q)

<400>  259

Gln Gln Phe Asn Ser Tyr Pro Leu Trp Ile Gln 
1               5                   10      


<210>  260
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR1


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa is Phe or Tyr

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Wherein Xaa is Thr, 
       Pro,Ala,Ser,Val,Leu,Ile,Met,His,Phe,Tyr,Asn,Asp,Glu, or Gln

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Wherein Xaa is Leu, or Met

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  260

Gly Xaa Xaa Phe Asp Asp His Ala Xaa His 
1               5                   10  


<210>  261
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR2


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein Xaa is Ser or Thr

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Wherein Xaa is His or Asn

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Wherein Xaa is Ile or Val

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Wherein Xaa is Gly, Ala, Ser, Thr, Val, Leu, Ile, Arg, His, or 
       Asn

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Wherein Xaa is Pro, Thr, Asn, As, Glu, Gln, Ser, His, or Tyr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Wherein  Xaa is 
       Pro,Gly,Ala,Ser,Thr,Val,Arg,His,Phe,Tyr,Asn,Asp,Arg, or Glu

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Wherein  Xaa is Val or Ile

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Wherein  Xaa is Ala, Ser, Thr, Val,Leu, Ile,Met, Lys, Arg, His, 
       Phe, Tyr, Asn, Asp, Glu, Arg, or Gln

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Wherein  Xaa is Gly, His, Asp, or Gln

<220>
<221>  misc_feature
<222>  (12)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  261

Gly Ile Xaa Trp Xaa Ser Arg Gly Xaa Gly Tyr Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210>  262
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC CDR3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Wherein X is Ser,Thr, Asn, Asp, Glu

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Wherein X is Lys, Met, Arg, or Ser

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Wherein Xaa is Gly, Ala, Ser, Thr, Val, Met, Asn, Glu, or Gln

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Wherein X is Ala, Ser, Thr, Val, Arg, His, Tyr, Trp, Asn, Glu, or
       Met

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  262

Asp Glu Tyr Xaa Xaa Gly Tyr Tyr Xaa Leu Asp Xaa 
1               5                   10          


<210>  263
<211>  11
<212>  PRT
<213>  Macaca fascicularis


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein Xaa is Ser, Thr, Val, Lys, Arg, His, Tyr or Ile

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Wherein Xaa is Ala, Ser, Thr, or Val

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Wherein Xaa is Pro,  Gly, Ala, Ser, Thr, Val, Leu, Ile, Met, Lys,
       Arg, His, Asn, Glu

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein Xaa is Pro, Gly, Ala, Ser, Thr, Val, Leu, Ile, Met, His, 
       Phe, Tyr, Asn, As, Glu

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Wherein Xaa is Pro, Gly, Aal, Ser, Thr, His, Glu, Gln, Met, Asn, 
       or Asp

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Wherein Xaa is Pro, Gly, Ala, Ser, Thr, Val, Leu, Ile, Asn

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Wherein Xaa is Ser, Thr, Val, Leu, Ile, Met, His, Phe, Tyr, Asn, 
       Asp, Glu, or Gln

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Wherein Xaa is Pro or Ala

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Wherein Xaa is Ala, Leu, or Val

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  263

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Xaa Xaa Ala 
1               5                   10      


<210>  264
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein Xaa is Gly, Ala, Ser, Met, His, Asn, Asp, Glu, or Gln

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Wherein Xaa is 
       Gly,Ala,Ser,Thr,Val,Met,His,Phe,Tyr,Asn,Asp,Glu,Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Wherein Ala,Ser,Phe,Tyr,Trp,Asn,Asp,Glu,Arg, Leu

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein Xaa is Pro, Ser, Tyr, Leu, Lys, His, or Asn

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Wherein Xaa is Asp, Glu, or Gln

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Wherein Xaa is Gly, Ser, Thr, Asn, Asp, Gln, Pro, Glu

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  264

Asp Xaa Xaa Xaa Xaa Xaa Xaa 
1               5           


<210>  265
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC CDR3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  wherein Xaa is Met or Gln

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  wherein Xaa is Gly, Ala, Asp, Glu, or Gln

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  wherein Xaa is Asn or Glu

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  wherein Xaa is Pro, Ala, or Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  wherein Xaa is Thr, Ile, Met, Lys, Trp, Asn, Glu

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Wherein Xaa is Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Wherein Xaa is Thr, Met, Leu, His, Tyr, Glu or Gly

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  265

Xaa Xaa Phe Xaa Xaa Tyr Pro Leu Xaa Xaa Xaa 
1               5                   10      


