                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  Treatment Of Ophthalmic Conditions With Angiopoietin-Like 7 
       (ANGPTL7) Inhibitors

<130>  189238.01602 (3152) (10512WO-01)

<150>  62/909,573
<151>  2019-10-02

<150>  62/902,683
<151>  2019-09-19

<150>  62/880,609
<151>  2019-07-30

<150>  62/795,665
<151>  2019-01-23

<160>  165   

<170>  PatentIn version 3.5

<210>  1
<211>  6641
<212>  DNA
<213>  homo sapien

<400>  1
cttgtggagc attcgggctt ggaaggaaag ctataggcta cccattcagc tcccctgtca       60

gagactcaag ctttgagaaa ggctagcaaa gagcaaggaa agagagaaaa caacaaagtg      120

gcgaggccct cagagtgaaa gcgtaaggtt cagtcagcct gctgcagctt tgcagacctc      180

agctgggcat ctccagactc ccctgaagga agagccttcc tcacccaaac ccacaaaaga      240

tgctgaaaaa gcctctctca gctgtgacct ggctctgcat tttcatcgtg gcctttgtca      300

gccacccagc gtggctgcag aagctctcta agcacaagac accagcacag ccacagctca      360

aagcggccaa ctgctgtgag gaggtgaagg agctcaaggc ccaagttgcc aaccttagca      420

gcctgctgag tgaactgaac aagaagcagg agagggactg ggtcagcgtg gtcatgcagg      480

tgatggagct ggagagcaac agcaagcgca tggagtcgcg gctcacagat gctgagagca      540

agtactccga gatgaacaac caaattgaca tcatgcagct gcaggcagca cagacggtca      600

ctcagacctc cgcaggtaag gagaccagtc ccctgaggga gcgtggagtg cctccccatc      660

tacagcactg cttctacata tcctggtcat cagaaccact actggggcct cttttgtggg      720

tacactttcc ctttagtaaa ggcttatgca gtatttcctt tgacttctaa tgctatgtaa      780

gtttacctaa caccttcacg ggtctctttt atccacacag tgtttcagcc taccatcttg      840

gagtgctgag atactacatg gtttgcccaa agtcacccag caagtcttag aagcagggtt      900

caagtcttcc tgattggtgt agctctgcta cttcctcacc aagagctgac aggctatatc      960

tcaagaaatt ccaaggaagc accaaactgt aacagctgtt cctctggaag caaagttttg     1020

ccagaaacag ttctctggtg ttcctaagat ttaccaggaa tgagcattaa tggaattttg     1080

tgtcctctct ctgtaaacgt aactcttctc attggctcag agttaagtgt agagacacat     1140

aaccatgtga agagtccctt tgtgttcagg aaggatgcgg ctccttaagg ttcctcaatt     1200

gtgatacgtc tatttttttc catggtctta aatgaatttc tccgaataca ggatttttta     1260

aatgcaatgc tgaaatatag acttaatagg ccaaaaataa gataaattta atctttcttt     1320

tgcaaaataa cttttatttc tggttagctc agctcaggtg ggccaacatg aatttacggt     1380

ttagagataa aaatttggtt ttctgaaatt atcaggaaaa tattagttgt aaggagcata     1440

tcctatagac atgtcatttc ttgctgatat aaaaaccatt ggtcccatta taaactacat     1500

gaagaacaaa gacatgatca gcttctactg actaagtcaa tggttaacct cagctcaaat     1560

taagaaaaag ttttaacatg aaaccaagct tgaaaattct gttacctgaa ccaacatgta     1620

tcaatcactt tctaagcatg gacttccggg ccctcagttt gggattagaa aggtattctc     1680

aggccatttt ccagacaagt gagtcctgat ttggtctgtg agatgaaacc agacatgcgg     1740

aagaccaggc cagacagagg aatctgaccg tgccacttcc tgctcatcca aacaggaggc     1800

tttctcacca tcctgcaagg aggttcttgg ggtcaagtgc agctctccca ccaggtctct     1860

tgctcttctt gcccaggaca tcattcctta tttttcttct ctatgaccaa gtgctcagtt     1920

acccttatat tctataagta ggtagtccct tagaggaagc agtaagttgg tgctttcacc     1980

actaagacga aatgaagaat agtgatggcg aaggcacacg tactctacct ccctttccca     2040

aggtgctctg caagagaacc tatgtgcctc agacaactcc catctgccat cttggtgctc     2100

ctctctaagg tcccagtgca gtggtcacca agaaaagcac cccgagacat agcaggcagg     2160

aagcttctct tggatagtaa gggccgcagt ctctgaatcc tatcagaaaa ggctgtctct     2220

tccactatgc tctttgatat ttagaataca gagcttaaat cctgcataaa gtagcagctc     2280

catggcccta gagtaaaaaa actggccagt ctgatgctct catttcattg ttttaacaaa     2340

acttctggga ggaaggcctc aaaggttctt ctgagtgttt tgaggtgcta gctggatgga     2400

aggggaaaat atgtgataat aaaatctatc tcccttaatt atggtctcag gtggcagtag     2460

ccaccatctc tgaacaacaa caaaaacaac caaccaggaa acatcaacaa aaccagactc     2520

tatgagatat tcacgactga tttgttatag tggcggctgt ctaagaagtc tgaatctatc     2580

tgacaggagt atctgttacg tggccctcat acactgtaac atttctagaa ttcatggccc     2640

agctatagca gaataattta tttcagagtt aacctgaaac cacctgttgg aacgtcccac     2700

taatgctatc caggtgaagg gcttccctac ccctctgctc caccgctagt aaagccaaaa     2760

tacaccccct ctggatctcc ccatatccac ctctcccaaa tgcagacact gatgggtaat     2820

taacaccact gagaatccca gggtagaaat aaaggctcag tctctaaaca ctcaactcag     2880

atggagccac tgggtctaaa tgctcaccct gtggtttgtt ctcttgtaga tgccatctac     2940

gactgctctt ccctctacca gaagaactac cgcatctctg gagtgtataa gcttcctcct     3000

gatgacttcc tgggcagccc tgaactggag gtgaggtcat tacagtcact ggccatgccc     3060

taatacctgt ccttcacccc ctcaagggga ctacaacaac agggccattc acagtttaaa     3120

gaaaggaaaa ttcggctggg cgcagtggct cacacctgta atcccagcac tatgggaggc     3180

cgaggcaggt ggatcacttc aggtcaggag tttaagacca gcctggccaa catggtgaaa     3240

ccctgtctct actaaaaata caaaaaaatt agccaggcat ggtggtgggc acctgtaatc     3300

cctgctacac aggaggattg cttgaactca ggaggcagag gttgcagtga gccgagatca     3360

cgccactgca ctataatctg ggagacaaag tgagactcca tttcaattaa aaaaaaaaaa     3420

aaaaaaaagg aaaactcaaa cacaagcaaa cacaccaaac accacagagc tatgcaaaca     3480

ctcagtttat gccctgcact ccaaacccag gcatctgttt ggccccttca aatcattatc     3540

agtcaaacaa caagccttct aacatagatc agatcattct tataaccacc acataactta     3600

gtttaaatct cttgccatgt cctagaacag ctattccttg ggggaggaga aaagaaaaca     3660

cgaaggcagc atcaaattat ctggattttc acccaggcat ggtggctcac acctgtaatc     3720

ccaagttttt tgggaggtga ggtgggcgga acaatcacct gaggtcagga ctttgagacc     3780

agcctggcca acatgctgaa acccagtctc tactaaaaat acaaaaatta gcccagtgtg     3840

gtgacaggca ctctggtccc agctactagg aaggcaggag aatcactgga actcaggagg     3900

tggaggttgc agtgagccga gattgcacca ctgtactcta gcctgggcaa caagagtgaa     3960

attctgcttc aaaaaaaaaa aaagtatctg gatttttccc tccaagcttc atgtgcactc     4020

acccccgggc ccaatttgca tcgttcttcc agagcaatgc accacccacc ccagctcacc     4080

agcagtgggg cagcatcact gcccgagtga gccagtgtga ctgcgggagt gcacacatct     4140

actggctctg cagggacagg aacaggttgg gaagcctgcc ctcttgctcc tgccttctgc     4200

ccctgcaagt ccctcaccag agtatcccct ctgcttcagg tgttctgtga catggagact     4260

tcaggcggag gctggaccat catccagaga cgaaaaagtg gccttgtctc cttctaccgg     4320

gactggaagc agtacaagca gggctttggc agcatccgtg gggacttctg gctggggaac     4380

gaacacatcc accggctctc cagacagcca acccggctgc gtgtagagat ggaggtaagc     4440

acaaggccag gggccccatg actggaccag tgccaccaca catgaccgcg tacaactccg     4500

ggggtgccat tcctattctg attcaagaca aatctgtata ttcattgtga tggttttcct     4560

gcaagttgta atggagttga ggaaaaatag gtatttttcc tttctgcaac ccccccaacc     4620

ccccgacaaa agtggggctg caggtgggac aggaagaggc cagacccagg ccagagtaga     4680

gcaaattcaa cagtcagctg tgccgaacac tagtctctgc tctggccgag catgaggtcc     4740

tttaggtgca aatcttactg atactgtttg gggacccttg ctgaaggtct gaaagcactc     4800

actatatcct catgtttctc ttacagcagc tctgtgtggg attcagcaaa aacatagctg     4860

caccttataa gcaggaaagt gaggaatata gaaagagaga ctaatcaagg ccatatggtg     4920

aatcaggaaa gaagttcgag ccttgttttc tgattcccag gttaacacag taaactggag     4980

gtaaacaagt aataaagtct tattagattc acacctataa aaagatgttt ggctatggga     5040

ctgtcaggag agaaggggta tagagacagc atgaaatgga gcctgctgca ctttctttaa     5100

ggctctgctc ctcctgacag gactgggagg gcaacctgcg ctacgctgag tatagccact     5160

ttgttttggg caatgaactc aacagctatc gcctcttcct ggggaactac actggcaatg     5220

tggggaacga cgccctccag tatcataaca acacagcctt cagcaccaag gacaaggaca     5280

atgacaactg cttggacaag tgtgcacagc tccgcaaagg tgagatttgg ggggaccgga     5340

aaggagaagt tcaggtacaa gctcataatc ccacttgagg agaaagagtg aattataact     5400

gtacagttga tattccggtt ttggtattct ttctgaccct ggctctaact ccttacctga     5460

tgtctggtct atcacagtca acttactagc actgggtctg tttctcatgc caggtggcta     5520

ctggtacaac tgctgcacag actccaacct caatggagtg tactaccgcc tgggtgagca     5580

caataagcac ctggatggca tcacctggta tggctggcat ggatctacct actccctcaa     5640

acgggtggag atgaaaatcc gcccagaaga cttcaagcct taaaaggagg ctgccgtgga     5700

gcacggatac agaaactgag acacgtggag actggatgag ggcagatgag gacaggaaga     5760

gagtgttaga aagggtagga ctgagaaaca gcctataatc tccaaagaaa gaataagtct     5820

ccaaggagca caaaaaaatc atatgtacca aggatgttac agtaaacagg atgaactatt     5880

taaacccact gggtcctgcc acatccttct caaggtggta gactgagtgg ggtctctctg     5940

cccaagatcc ctgacatagc agtagcttgt cttttccaca tgatttgtct gtgaaagaaa     6000

ataattttga gatcgtttta tctattttct ctacggctta ggctatgtga gggcaaaaca     6060

caaatccctt tgctaaaaag aaccatatta ttttgattct caaaggatag gcctttgagt     6120

gttagagaaa ggagtgaagg aggcaggtgg gaaatggtat ttctattttt aaatccagtg     6180

aaattatctt gagtctacac attattttta aaacacaaaa attgttcggc tggaactgac     6240

ccaggctgga cttgcgggga ggaaactcca gggcactgca tctggcgatc agactctgag     6300

cactgcccct gctcgccttg gtcatgtaca gcactgaaag gaatgaagca ccagcaggag     6360

gtggacagag tctctcatgg atgccggcac aaaactgcct taaaatattc atagttaata     6420

caggtatatc tatttttatt tactttgtaa gaaacaagct caaggagctt ccttttaaat     6480

tttgtctgta ggaaatggtt gaaaactgaa ggtagatggt gttatagtta ataataaatg     6540

ctgtaaataa gcatctcact ttgtaaaaat aaaatattgt ggttttgttt taaacattca     6600

acgtttcttt tccttctaca ataaacactt tcaaaatgtg a                         6641


<210>  2
<211>  6641
<212>  DNA
<213>  homo sapien

<400>  2
cttgtggagc attcgggctt ggaaggaaag ctataggcta cccattcagc tcccctgtca       60

gagactcaag ctttgagaaa ggctagcaaa gagcaaggaa agagagaaaa caacaaagtg      120

gcgaggccct cagagtgaaa gcgtaaggtt cagtcagcct gctgcagctt tgcagacctc      180

agctgggcat ctccagactc ccctgaagga agagccttcc tcacccaaac ccacaaaaga      240

tgctgaaaaa gcctctctca gctgtgacct ggctctgcat tttcatcgtg gcctttgtca      300

gccacccagc gtggctgcag aagctctcta agcacaagac accagcacag ccacagctca      360

aagcggccaa ctgctgtgag gaggtgaagg agctcaaggc ccaagttgcc aaccttagca      420

gcctgctgag tgaactgaac aagaagcagg agagggactg ggtcagcgtg gtcatgcagg      480

tgatggagct ggagagcaac agcaagcgca tggagtcgcg gctcacagat gctgagagca      540

agtactccga gatgaacaac caaattgaca tcatgcagct gcaggcagca cagacggtca      600

ctcagacctc cgcaggtaag gagaccagtc ccctgaggga gcgtggagtg cctccccatc      660

tacagcactg cttctacata tcctggtcat cagaaccact actggggcct cttttgtggg      720

tacactttcc ctttagtaaa ggcttatgca gtatttcctt tgacttctaa tgctatgtaa      780

gtttacctaa caccttcacg ggtctctttt atccacacag tgtttcagcc taccatcttg      840

gagtgctgag atactacatg gtttgcccaa agtcacccag caagtcttag aagcagggtt      900

caagtcttcc tgattggtgt agctctgcta cttcctcacc aagagctgac aggctatatc      960

tcaagaaatt ccaaggaagc accaaactgt aacagctgtt cctctggaag caaagttttg     1020

ccagaaacag ttctctggtg ttcctaagat ttaccaggaa tgagcattaa tggaattttg     1080

tgtcctctct ctgtaaacgt aactcttctc attggctcag agttaagtgt agagacacat     1140

aaccatgtga agagtccctt tgtgttcagg aaggatgcgg ctccttaagg ttcctcaatt     1200

gtgatacgtc tatttttttc catggtctta aatgaatttc tccgaataca ggatttttta     1260

aatgcaatgc tgaaatatag acttaatagg ccaaaaataa gataaattta atctttcttt     1320

tgcaaaataa cttttatttc tggttagctc agctcaggtg ggccaacatg aatttacggt     1380

ttagagataa aaatttggtt ttctgaaatt atcaggaaaa tattagttgt aaggagcata     1440

tcctatagac atgtcatttc ttgctgatat aaaaaccatt ggtcccatta taaactacat     1500

gaagaacaaa gacatgatca gcttctactg actaagtcaa tggttaacct cagctcaaat     1560

taagaaaaag ttttaacatg aaaccaagct tgaaaattct gttacctgaa ccaacatgta     1620

tcaatcactt tctaagcatg gacttccggg ccctcagttt gggattagaa aggtattctc     1680

aggccatttt ccagacaagt gagtcctgat ttggtctgtg agatgaaacc agacatgcgg     1740

aagaccaggc cagacagagg aatctgaccg tgccacttcc tgctcatcca aacaggaggc     1800

tttctcacca tcctgcaagg aggttcttgg ggtcaagtgc agctctccca ccaggtctct     1860

tgctcttctt gcccaggaca tcattcctta tttttcttct ctatgaccaa gtgctcagtt     1920

acccttatat tctataagta ggtagtccct tagaggaagc agtaagttgg tgctttcacc     1980

actaagacga aatgaagaat agtgatggcg aaggcacacg tactctacct ccctttccca     2040

aggtgctctg caagagaacc tatgtgcctc agacaactcc catctgccat cttggtgctc     2100

ctctctaagg tcccagtgca gtggtcacca agaaaagcac cccgagacat agcaggcagg     2160

aagcttctct tggatagtaa gggccgcagt ctctgaatcc tatcagaaaa ggctgtctct     2220

tccactatgc tctttgatat ttagaataca gagcttaaat cctgcataaa gtagcagctc     2280

catggcccta gagtaaaaaa actggccagt ctgatgctct catttcattg ttttaacaaa     2340

acttctggga ggaaggcctc aaaggttctt ctgagtgttt tgaggtgcta gctggatgga     2400

aggggaaaat atgtgataat aaaatctatc tcccttaatt atggtctcag gtggcagtag     2460

ccaccatctc tgaacaacaa caaaaacaac caaccaggaa acatcaacaa aaccagactc     2520

tatgagatat tcacgactga tttgttatag tggcggctgt ctaagaagtc tgaatctatc     2580

tgacaggagt atctgttacg tggccctcat acactgtaac atttctagaa ttcatggccc     2640

agctatagca gaataattta tttcagagtt aacctgaaac cacctgttgg aacgtcccac     2700

taatgctatc caggtgaagg gcttccctac ccctctgctc caccgctagt aaagccaaaa     2760

tacaccccct ctggatctcc ccatatccac ctctcccaaa tgcagacact gatgggtaat     2820

taacaccact gagaatccca gggtagaaat aaaggctcag tctctaaaca ctcaactcag     2880

atggagccac tgggtctaaa tgctcaccct gtggtttgtt ctcttgtaga tgccatctac     2940

gactgctctt ccctctacca gaagaactac cgcatctctg gagtgtataa gcttcctcct     3000

gatgacttcc tgggcagccc tgaactggag gtgaggtcat tacagtcact ggccatgccc     3060

taatacctgt ccttcacccc ctcaagggga ctacaacaac agggccattc acagtttaaa     3120

gaaaggaaaa ttcggctggg cgcagtggct cacacctgta atcccagcac tatgggaggc     3180

cgaggcaggt ggatcacttc aggtcaggag tttaagacca gcctggccaa catggtgaaa     3240

ccctgtctct actaaaaata caaaaaaatt agccaggcat ggtggtgggc acctgtaatc     3300

cctgctacac aggaggattg cttgaactca ggaggcagag gttgcagtga gccgagatca     3360

cgccactgca ctataatctg ggagacaaag tgagactcca tttcaattaa aaaaaaaaaa     3420

aaaaaaaagg aaaactcaaa cacaagcaaa cacaccaaac accacagagc tatgcaaaca     3480

ctcagtttat gccctgcact ccaaacccag gcatctgttt ggccccttca aatcattatc     3540

agtcaaacaa caagccttct aacatagatc agatcattct tataaccacc acataactta     3600

gtttaaatct cttgccatgt cctagaacag ctattccttg ggggaggaga aaagaaaaca     3660

cgaaggcagc atcaaattat ctggattttc acccaggcat ggtggctcac acctgtaatc     3720

ccaagttttt tgggaggtga ggtgggcgga acaatcacct gaggtcagga ctttgagacc     3780

agcctggcca acatgctgaa acccagtctc tactaaaaat acaaaaatta gcccagtgtg     3840

gtgacaggca ctctggtccc agctactagg aaggcaggag aatcactgga actcaggagg     3900

tggaggttgc agtgagccga gattgcacca ctgtactcta gcctgggcaa caagagtgaa     3960

attctgcttc aaaaaaaaaa aaagtatctg gatttttccc tccaagcttc atgtgcactc     4020

acccccgggc ccaatttgca tcgttcttcc agagcaatgc accacccacc ccagctcacc     4080

agcagtgggg cagcatcact gcccgagtga gccagtgtga ctgcgggagt gcacacatct     4140

actggctctg cagggacagg aacaggttgg gaagcctgcc ctcttgctcc tgccttctgc     4200

ccctgcaagt ccctcaccag agtatcccct ctgcttcagg tgttctgtga catggagact     4260

tcaggcggag gctggaccat catccagaga tgaaaaagtg gccttgtctc cttctaccgg     4320

gactggaagc agtacaagca gggctttggc agcatccgtg gggacttctg gctggggaac     4380

gaacacatcc accggctctc cagacagcca acccggctgc gtgtagagat ggaggtaagc     4440

acaaggccag gggccccatg actggaccag tgccaccaca catgaccgcg tacaactccg     4500

ggggtgccat tcctattctg attcaagaca aatctgtata ttcattgtga tggttttcct     4560

gcaagttgta atggagttga ggaaaaatag gtatttttcc tttctgcaac ccccccaacc     4620

ccccgacaaa agtggggctg caggtgggac aggaagaggc cagacccagg ccagagtaga     4680

gcaaattcaa cagtcagctg tgccgaacac tagtctctgc tctggccgag catgaggtcc     4740

tttaggtgca aatcttactg atactgtttg gggacccttg ctgaaggtct gaaagcactc     4800

actatatcct catgtttctc ttacagcagc tctgtgtggg attcagcaaa aacatagctg     4860

caccttataa gcaggaaagt gaggaatata gaaagagaga ctaatcaagg ccatatggtg     4920

aatcaggaaa gaagttcgag ccttgttttc tgattcccag gttaacacag taaactggag     4980

gtaaacaagt aataaagtct tattagattc acacctataa aaagatgttt ggctatggga     5040

ctgtcaggag agaaggggta tagagacagc atgaaatgga gcctgctgca ctttctttaa     5100

ggctctgctc ctcctgacag gactgggagg gcaacctgcg ctacgctgag tatagccact     5160

ttgttttggg caatgaactc aacagctatc gcctcttcct ggggaactac actggcaatg     5220

tggggaacga cgccctccag tatcataaca acacagcctt cagcaccaag gacaaggaca     5280

atgacaactg cttggacaag tgtgcacagc tccgcaaagg tgagatttgg ggggaccgga     5340

aaggagaagt tcaggtacaa gctcataatc ccacttgagg agaaagagtg aattataact     5400

gtacagttga tattccggtt ttggtattct ttctgaccct ggctctaact ccttacctga     5460

tgtctggtct atcacagtca acttactagc actgggtctg tttctcatgc caggtggcta     5520

ctggtacaac tgctgcacag actccaacct caatggagtg tactaccgcc tgggtgagca     5580

caataagcac ctggatggca tcacctggta tggctggcat ggatctacct actccctcaa     5640

acgggtggag atgaaaatcc gcccagaaga cttcaagcct taaaaggagg ctgccgtgga     5700

gcacggatac agaaactgag acacgtggag actggatgag ggcagatgag gacaggaaga     5760

gagtgttaga aagggtagga ctgagaaaca gcctataatc tccaaagaaa gaataagtct     5820

ccaaggagca caaaaaaatc atatgtacca aggatgttac agtaaacagg atgaactatt     5880

taaacccact gggtcctgcc acatccttct caaggtggta gactgagtgg ggtctctctg     5940

cccaagatcc ctgacatagc agtagcttgt cttttccaca tgatttgtct gtgaaagaaa     6000

ataattttga gatcgtttta tctattttct ctacggctta ggctatgtga gggcaaaaca     6060

caaatccctt tgctaaaaag aaccatatta ttttgattct caaaggatag gcctttgagt     6120

gttagagaaa ggagtgaagg aggcaggtgg gaaatggtat ttctattttt aaatccagtg     6180

aaattatctt gagtctacac attattttta aaacacaaaa attgttcggc tggaactgac     6240

ccaggctgga cttgcgggga ggaaactcca gggcactgca tctggcgatc agactctgag     6300

cactgcccct gctcgccttg gtcatgtaca gcactgaaag gaatgaagca ccagcaggag     6360

gtggacagag tctctcatgg atgccggcac aaaactgcct taaaatattc atagttaata     6420

caggtatatc tatttttatt tactttgtaa gaaacaagct caaggagctt ccttttaaat     6480

tttgtctgta ggaaatggtt gaaaactgaa ggtagatggt gttatagtta ataataaatg     6540

ctgtaaataa gcatctcact ttgtaaaaat aaaatattgt ggttttgttt taaacattca     6600

acgtttcttt tccttctaca ataaacactt tcaaaatgtg a                         6641


<210>  3
<211>  6641
<212>  DNA
<213>  homo sapien

<400>  3
cttgtggagc attcgggctt ggaaggaaag ctataggcta cccattcagc tcccctgtca       60

gagactcaag ctttgagaaa ggctagcaaa gagcaaggaa agagagaaaa caacaaagtg      120

gcgaggccct cagagtgaaa gcgtaaggtt cagtcagcct gctgcagctt tgcagacctc      180

agctgggcat ctccagactc ccctgaagga agagccttcc tcacccaaac ccacaaaaga      240

tgctgaaaaa gcctctctca gctgtgacct ggctctgcat tttcatcgtg gcctttgtca      300

gccacccagc gtggctgcag aagctctcta agcacaagac accagcacag ccacagctca      360

aagcggccaa ctgctgtgag gaggtgaagg agctcaaggc ccaagttgcc aaccttagca      420

gcctgctgag tgaactgaac aagaagcagg agagggactg ggtcagcgtg gtcatgcagg      480

tgatggagct ggagagcaac agcaagcgca tggagtcgcg gctcacagat gctgagagca      540

agtactccga gatgaacaac caaattgaca tcatgcagct gcaggcagca cagacggtca      600

ctcagacctc cgcaggtaag gagaccagtc ccctgaggga gcgtggagtg cctccccatc      660

tacagcactg cttctacata tcctggtcat cagaaccact actggggcct cttttgtggg      720

tacactttcc ctttagtaaa ggcttatgca gtatttcctt tgacttctaa tgctatgtaa      780

gtttacctaa caccttcacg ggtctctttt atccacacag tgtttcagcc taccatcttg      840

gagtgctgag atactacatg gtttgcccaa agtcacccag caagtcttag aagcagggtt      900

caagtcttcc tgattggtgt agctctgcta cttcctcacc aagagctgac aggctatatc      960

tcaagaaatt ccaaggaagc accaaactgt aacagctgtt cctctggaag caaagttttg     1020

ccagaaacag ttctctggtg ttcctaagat ttaccaggaa tgagcattaa tggaattttg     1080

tgtcctctct ctgtaaacgt aactcttctc attggctcag agttaagtgt agagacacat     1140

aaccatgtga agagtccctt tgtgttcagg aaggatgcgg ctccttaagg ttcctcaatt     1200

gtgatacgtc tatttttttc catggtctta aatgaatttc tccgaataca ggatttttta     1260

aatgcaatgc tgaaatatag acttaatagg ccaaaaataa gataaattta atctttcttt     1320

tgcaaaataa cttttatttc tggttagctc agctcaggtg ggccaacatg aatttacggt     1380

ttagagataa aaatttggtt ttctgaaatt atcaggaaaa tattagttgt aaggagcata     1440

tcctatagac atgtcatttc ttgctgatat aaaaaccatt ggtcccatta taaactacat     1500

gaagaacaaa gacatgatca gcttctactg actaagtcaa tggttaacct cagctcaaat     1560

taagaaaaag ttttaacatg aaaccaagct tgaaaattct gttacctgaa ccaacatgta     1620

tcaatcactt tctaagcatg gacttccggg ccctcagttt gggattagaa aggtattctc     1680

aggccatttt ccagacaagt gagtcctgat ttggtctgtg agatgaaacc agacatgcgg     1740

aagaccaggc cagacagagg aatctgaccg tgccacttcc tgctcatcca aacaggaggc     1800

tttctcacca tcctgcaagg aggttcttgg ggtcaagtgc agctctccca ccaggtctct     1860

tgctcttctt gcccaggaca tcattcctta tttttcttct ctatgaccaa gtgctcagtt     1920

acccttatat tctataagta ggtagtccct tagaggaagc agtaagttgg tgctttcacc     1980

actaagacga aatgaagaat agtgatggcg aaggcacacg tactctacct ccctttccca     2040

aggtgctctg caagagaacc tatgtgcctc agacaactcc catctgccat cttggtgctc     2100

ctctctaagg tcccagtgca gtggtcacca agaaaagcac cccgagacat agcaggcagg     2160

aagcttctct tggatagtaa gggccgcagt ctctgaatcc tatcagaaaa ggctgtctct     2220

tccactatgc tctttgatat ttagaataca gagcttaaat cctgcataaa gtagcagctc     2280

catggcccta gagtaaaaaa actggccagt ctgatgctct catttcattg ttttaacaaa     2340

acttctggga ggaaggcctc aaaggttctt ctgagtgttt tgaggtgcta gctggatgga     2400

aggggaaaat atgtgataat aaaatctatc tcccttaatt atggtctcag gtggcagtag     2460

ccaccatctc tgaacaacaa caaaaacaac caaccaggaa acatcaacaa aaccagactc     2520

tatgagatat tcacgactga tttgttatag tggcggctgt ctaagaagtc tgaatctatc     2580

tgacaggagt atctgttacg tggccctcat acactgtaac atttctagaa ttcatggccc     2640

agctatagca gaataattta tttcagagtt aacctgaaac cacctgttgg aacgtcccac     2700

taatgctatc caggtgaagg gcttccctac ccctctgctc caccgctagt aaagccaaaa     2760

tacaccccct ctggatctcc ccatatccac ctctcccaaa tgcagacact gatgggtaat     2820

taacaccact gagaatccca gggtagaaat aaaggctcag tctctaaaca ctcaactcag     2880

atggagccac tgggtctaaa tgctcaccct gtggtttgtt ctcttgtaga tgccatctac     2940

gactgctctt ccctctacca gaagaactac cgcatctctg gagtgtataa gcttcctcct     3000

gatgacttcc tgggcagccc tgaactggag gtgaggtcat tacagtcact ggccatgccc     3060

taatacctgt ccttcacccc ctcaagggga ctacaacaac agggccattc acagtttaaa     3120

gaaaggaaaa ttcggctggg cgcagtggct cacacctgta atcccagcac tatgggaggc     3180

cgaggcaggt ggatcacttc aggtcaggag tttaagacca gcctggccaa catggtgaaa     3240

ccctgtctct actaaaaata caaaaaaatt agccaggcat ggtggtgggc acctgtaatc     3300

cctgctacac aggaggattg cttgaactca ggaggcagag gttgcagtga gccgagatca     3360

cgccactgca ctataatctg ggagacaaag tgagactcca tttcaattaa aaaaaaaaaa     3420

aaaaaaaagg aaaactcaaa cacaagcaaa cacaccaaac accacagagc tatgcaaaca     3480

ctcagtttat gccctgcact ccaaacccag gcatctgttt ggccccttca aatcattatc     3540

agtcaaacaa caagccttct aacatagatc agatcattct tataaccacc acataactta     3600

gtttaaatct cttgccatgt cctagaacag ctattccttg ggggaggaga aaagaaaaca     3660

cgaaggcagc atcaaattat ctggattttc acccaggcat ggtggctcac acctgtaatc     3720

ccaagttttt tgggaggtga ggtgggcgga acaatcacct gaggtcagga ctttgagacc     3780

agcctggcca acatgctgaa acccagtctc tactaaaaat acaaaaatta gcccagtgtg     3840

gtgacaggca ctctggtccc agctactagg aaggcaggag aatcactgga actcaggagg     3900

tggaggttgc agtgagccga gattgcacca ctgtactcta gcctgggcaa caagagtgaa     3960

attctgcttc aaaaaaaaaa aaagtatctg gatttttccc tccaagcttc atgtgcactc     4020

acccccgggc ccaatttgca tcgttcttcc agagcaatgc accacccacc ccagctcacc     4080

agcagtgggg cagcatcact gcccgagtga gccagtgtga ctgcgggagt gcacacatct     4140

actggctctg cagggacagg aacaggttgg gaagcctgcc ctcttgctcc tgccttctgc     4200

ccctgcaagt ccctcaccag agtatcccct ctgcttcagg tgttctgtga catggagact     4260

tcaggcggag gctggaccat catccataga cgaaaaagtg gccttgtctc cttctaccgg     4320

gactggaagc agtacaagca gggctttggc agcatccgtg gggacttctg gctggggaac     4380

gaacacatcc accggctctc cagacagcca acccggctgc gtgtagagat ggaggtaagc     4440

acaaggccag gggccccatg actggaccag tgccaccaca catgaccgcg tacaactccg     4500

ggggtgccat tcctattctg attcaagaca aatctgtata ttcattgtga tggttttcct     4560

gcaagttgta atggagttga ggaaaaatag gtatttttcc tttctgcaac ccccccaacc     4620

ccccgacaaa agtggggctg caggtgggac aggaagaggc cagacccagg ccagagtaga     4680

gcaaattcaa cagtcagctg tgccgaacac tagtctctgc tctggccgag catgaggtcc     4740

tttaggtgca aatcttactg atactgtttg gggacccttg ctgaaggtct gaaagcactc     4800

actatatcct catgtttctc ttacagcagc tctgtgtggg attcagcaaa aacatagctg     4860

caccttataa gcaggaaagt gaggaatata gaaagagaga ctaatcaagg ccatatggtg     4920

aatcaggaaa gaagttcgag ccttgttttc tgattcccag gttaacacag taaactggag     4980

gtaaacaagt aataaagtct tattagattc acacctataa aaagatgttt ggctatggga     5040

ctgtcaggag agaaggggta tagagacagc atgaaatgga gcctgctgca ctttctttaa     5100

ggctctgctc ctcctgacag gactgggagg gcaacctgcg ctacgctgag tatagccact     5160

ttgttttggg caatgaactc aacagctatc gcctcttcct ggggaactac actggcaatg     5220

tggggaacga cgccctccag tatcataaca acacagcctt cagcaccaag gacaaggaca     5280

atgacaactg cttggacaag tgtgcacagc tccgcaaagg tgagatttgg ggggaccgga     5340

aaggagaagt tcaggtacaa gctcataatc ccacttgagg agaaagagtg aattataact     5400

gtacagttga tattccggtt ttggtattct ttctgaccct ggctctaact ccttacctga     5460

tgtctggtct atcacagtca acttactagc actgggtctg tttctcatgc caggtggcta     5520

ctggtacaac tgctgcacag actccaacct caatggagtg tactaccgcc tgggtgagca     5580

caataagcac ctggatggca tcacctggta tggctggcat ggatctacct actccctcaa     5640

acgggtggag atgaaaatcc gcccagaaga cttcaagcct taaaaggagg ctgccgtgga     5700

gcacggatac agaaactgag acacgtggag actggatgag ggcagatgag gacaggaaga     5760

gagtgttaga aagggtagga ctgagaaaca gcctataatc tccaaagaaa gaataagtct     5820

ccaaggagca caaaaaaatc atatgtacca aggatgttac agtaaacagg atgaactatt     5880

taaacccact gggtcctgcc acatccttct caaggtggta gactgagtgg ggtctctctg     5940

cccaagatcc ctgacatagc agtagcttgt cttttccaca tgatttgtct gtgaaagaaa     6000

ataattttga gatcgtttta tctattttct ctacggctta ggctatgtga gggcaaaaca     6060

caaatccctt tgctaaaaag aaccatatta ttttgattct caaaggatag gcctttgagt     6120

gttagagaaa ggagtgaagg aggcaggtgg gaaatggtat ttctattttt aaatccagtg     6180

aaattatctt gagtctacac attattttta aaacacaaaa attgttcggc tggaactgac     6240

ccaggctgga cttgcgggga ggaaactcca gggcactgca tctggcgatc agactctgag     6300

cactgcccct gctcgccttg gtcatgtaca gcactgaaag gaatgaagca ccagcaggag     6360

gtggacagag tctctcatgg atgccggcac aaaactgcct taaaatattc atagttaata     6420

caggtatatc tatttttatt tactttgtaa gaaacaagct caaggagctt ccttttaaat     6480

tttgtctgta ggaaatggtt gaaaactgaa ggtagatggt gttatagtta ataataaatg     6540

ctgtaaataa gcatctcact ttgtaaaaat aaaatattgt ggttttgttt taaacattca     6600

acgtttcttt tccttctaca ataaacactt tcaaaatgtg a                         6641


<210>  4
<211>  1041
<212>  DNA
<213>  homo sapien

<400>  4
augcugaaaa agccucucuc agcugugacc uggcucugca uuuucaucgu ggccuuuguc       60

agccacccag cguggcugca gaagcucucu aagcacaaga caccagcaca gccacagcuc      120

aaagcggcca acugcuguga ggaggugaag gagcucaagg cccaaguugc caaccuuagc      180

agccugcuga gugaacugaa caagaagcag gagagggacu gggucagcgu ggucaugcag      240

gugauggagc uggagagcaa cagcaagcgc auggagucgc ggcucacaga ugcugagagc      300

aaguacuccg agaugaacaa ccaaauugac aucaugcagc ugcaggcagc acagacgguc      360

acucagaccu ccgcagaugc caucuacgac ugcucuuccc ucuaccagaa gaacuaccgc      420

aucucuggag uguauaagcu uccuccugau gacuuccugg gcagcccuga acuggaggug      480

uucugugaca uggagacuuc aggcggaggc uggaccauca uccagagacg aaaaaguggc      540

cuugucuccu ucuaccggga cuggaagcag uacaagcagg gcuuuggcag cauccguggg      600

gacuucuggc uggggaacga acacauccac cggcucucca gacagccaac ccggcugcgu      660

guagagaugg aggacuggga gggcaaccug cgcuacgcug aguauagcca cuuuguuuug      720

ggcaaugaac ucaacagcua ucgccucuuc cuggggaacu acacuggcaa uguggggaac      780

gacgcccucc aguaucauaa caacacagcc uucagcacca aggacaagga caaugacaac      840

ugcuuggaca agugugcaca gcuccgcaaa gguggcuacu gguacaacug cugcacagac      900

uccaaccuca auggagugua cuaccgccug ggugagcaca auaagcaccu ggauggcauc      960

accugguaug gcuggcaugg aucuaccuac ucccucaaac ggguggagau gaaaauccgc     1020

ccagaagacu ucaagccuua a                                               1041


<210>  5
<211>  531
<212>  DNA
<213>  homo sapien

<400>  5
augcugaaaa agccucucuc agcugugacc uggcucugca uuuucaucgu ggccuuuguc       60

agccacccag cguggcugca gaagcucucu aagcacaaga caccagcaca gccacagcuc      120

aaagcggcca acugcuguga ggaggugaag gagcucaagg cccaaguugc caaccuuagc      180

agccugcuga gugaacugaa caagaagcag gagagggacu gggucagcgu ggucaugcag      240

gugauggagc uggagagcaa cagcaagcgc auggagucgc ggcucacaga ugcugagagc      300

aaguacuccg agaugaacaa ccaaauugac aucaugcagc ugcaggcagc acagacgguc      360

acucagaccu ccgcagaugc caucuacgac ugcucuuccc ucuaccagaa gaacuaccgc      420

aucucuggag uguauaagcu uccuccugau gacuuccugg gcagcccuga acuggaggug      480

uucugugaca uggagacuuc aggcggaggc uggaccauca uccagagaug a               531


<210>  6
<211>  1041
<212>  DNA
<213>  homo sapien

<400>  6
augcugaaaa agccucucuc agcugugacc uggcucugca uuuucaucgu ggccuuuguc       60

agccacccag cguggcugca gaagcucucu aagcacaaga caccagcaca gccacagcuc      120

aaagcggcca acugcuguga ggaggugaag gagcucaagg cccaaguugc caaccuuagc      180

agccugcuga gugaacugaa caagaagcag gagagggacu gggucagcgu ggucaugcag      240

gugauggagc uggagagcaa cagcaagcgc auggagucgc ggcucacaga ugcugagagc      300

aaguacuccg agaugaacaa ccaaauugac aucaugcagc ugcaggcagc acagacgguc      360

acucagaccu ccgcagaugc caucuacgac ugcucuuccc ucuaccagaa gaacuaccgc      420

aucucuggag uguauaagcu uccuccugau gacuuccugg gcagcccuga acuggaggug      480

uucugugaca uggagacuuc aggcggaggc uggaccauca uccauagacg aaaaaguggc      540

cuugucuccu ucuaccggga cuggaagcag uacaagcagg gcuuuggcag cauccguggg      600

gacuucuggc uggggaacga acacauccac cggcucucca gacagccaac ccggcugcgu      660

guagagaugg aggacuggga gggcaaccug cgcuacgcug aguauagcca cuuuguuuug      720

ggcaaugaac ucaacagcua ucgccucuuc cuggggaacu acacuggcaa uguggggaac      780

gacgcccucc aguaucauaa caacacagcc uucagcacca aggacaagga caaugacaac      840

ugcuuggaca agugugcaca gcuccgcaaa gguggcuacu gguacaacug cugcacagac      900

uccaaccuca auggagugua cuaccgccug ggugagcaca auaagcaccu ggauggcauc      960

accugguaug gcuggcaugg aucuaccuac ucccucaaac ggguggagau gaaaauccgc     1020

ccagaagacu ucaagccuua a                                               1041


<210>  7
<211>  1041
<212>  DNA
<213>  homo sapien

<400>  7
atgctgaaaa agcctctctc agctgtgacc tggctctgca ttttcatcgt ggcctttgtc       60

agccacccag cgtggctgca gaagctctct aagcacaaga caccagcaca gccacagctc      120

aaagcggcca actgctgtga ggaggtgaag gagctcaagg cccaagttgc caaccttagc      180

agcctgctga gtgaactgaa caagaagcag gagagggact gggtcagcgt ggtcatgcag      240

gtgatggagc tggagagcaa cagcaagcgc atggagtcgc ggctcacaga tgctgagagc      300

aagtactccg agatgaacaa ccaaattgac atcatgcagc tgcaggcagc acagacggtc      360

actcagacct ccgcagatgc catctacgac tgctcttccc tctaccagaa gaactaccgc      420

atctctggag tgtataagct tcctcctgat gacttcctgg gcagccctga actggaggtg      480

ttctgtgaca tggagacttc aggcggaggc tggaccatca tccagagacg aaaaagtggc      540

cttgtctcct tctaccggga ctggaagcag tacaagcagg gctttggcag catccgtggg      600

gacttctggc tggggaacga acacatccac cggctctcca gacagccaac ccggctgcgt      660

gtagagatgg aggactggga gggcaacctg cgctacgctg agtatagcca ctttgttttg      720

ggcaatgaac tcaacagcta tcgcctcttc ctggggaact acactggcaa tgtggggaac      780

gacgccctcc agtatcataa caacacagcc ttcagcacca aggacaagga caatgacaac      840

tgcttggaca agtgtgcaca gctccgcaaa ggtggctact ggtacaactg ctgcacagac      900

tccaacctca atggagtgta ctaccgcctg ggtgagcaca ataagcacct ggatggcatc      960

acctggtatg gctggcatgg atctacctac tccctcaaac gggtggagat gaaaatccgc     1020

ccagaagact tcaagcctta a                                               1041


<210>  8
<211>  531
<212>  DNA
<213>  homo sapien

<400>  8
atgctgaaaa agcctctctc agctgtgacc tggctctgca ttttcatcgt ggcctttgtc       60

agccacccag cgtggctgca gaagctctct aagcacaaga caccagcaca gccacagctc      120

aaagcggcca actgctgtga ggaggtgaag gagctcaagg cccaagttgc caaccttagc      180

agcctgctga gtgaactgaa caagaagcag gagagggact gggtcagcgt ggtcatgcag      240

gtgatggagc tggagagcaa cagcaagcgc atggagtcgc ggctcacaga tgctgagagc      300

aagtactccg agatgaacaa ccaaattgac atcatgcagc tgcaggcagc acagacggtc      360

actcagacct ccgcagatgc catctacgac tgctcttccc tctaccagaa gaactaccgc      420

atctctggag tgtataagct tcctcctgat gacttcctgg gcagccctga actggaggtg      480

ttctgtgaca tggagacttc aggcggaggc tggaccatca tccagagatg a               531


<210>  9
<211>  1041
<212>  DNA
<213>  homo sapien

<400>  9
atgctgaaaa agcctctctc agctgtgacc tggctctgca ttttcatcgt ggcctttgtc       60

agccacccag cgtggctgca gaagctctct aagcacaaga caccagcaca gccacagctc      120

aaagcggcca actgctgtga ggaggtgaag gagctcaagg cccaagttgc caaccttagc      180

agcctgctga gtgaactgaa caagaagcag gagagggact gggtcagcgt ggtcatgcag      240

gtgatggagc tggagagcaa cagcaagcgc atggagtcgc ggctcacaga tgctgagagc      300

aagtactccg agatgaacaa ccaaattgac atcatgcagc tgcaggcagc acagacggtc      360

actcagacct ccgcagatgc catctacgac tgctcttccc tctaccagaa gaactaccgc      420

atctctggag tgtataagct tcctcctgat gacttcctgg gcagccctga actggaggtg      480

ttctgtgaca tggagacttc aggcggaggc tggaccatca tccatagacg aaaaagtggc      540

cttgtctcct tctaccggga ctggaagcag tacaagcagg gctttggcag catccgtggg      600

gacttctggc tggggaacga acacatccac cggctctcca gacagccaac ccggctgcgt      660

gtagagatgg aggactggga gggcaacctg cgctacgctg agtatagcca ctttgttttg      720

ggcaatgaac tcaacagcta tcgcctcttc ctggggaact acactggcaa tgtggggaac      780

gacgccctcc agtatcataa caacacagcc ttcagcacca aggacaagga caatgacaac      840

tgcttggaca agtgtgcaca gctccgcaaa ggtggctact ggtacaactg ctgcacagac      900

tccaacctca atggagtgta ctaccgcctg ggtgagcaca ataagcacct ggatggcatc      960

acctggtatg gctggcatgg atctacctac tccctcaaac gggtggagat gaaaatccgc     1020

ccagaagact tcaagcctta a                                               1041


<210>  10
<211>  346
<212>  PRT
<213>  homo sapien

<400>  10

Met Leu Lys Lys Pro Leu Ser Ala Val Thr Trp Leu Cys Ile Phe Ile 
1               5                   10                  15      


Val Ala Phe Val Ser His Pro Ala Trp Leu Gln Lys Leu Ser Lys His 
            20                  25                  30          


Lys Thr Pro Ala Gln Pro Gln Leu Lys Ala Ala Asn Cys Cys Glu Glu 
        35                  40                  45              


Val Lys Glu Leu Lys Ala Gln Val Ala Asn Leu Ser Ser Leu Leu Ser 
    50                  55                  60                  


Glu Leu Asn Lys Lys Gln Glu Arg Asp Trp Val Ser Val Val Met Gln 
65                  70                  75                  80  


Val Met Glu Leu Glu Ser Asn Ser Lys Arg Met Glu Ser Arg Leu Thr 
                85                  90                  95      


Asp Ala Glu Ser Lys Tyr Ser Glu Met Asn Asn Gln Ile Asp Ile Met 
            100                 105                 110         


Gln Leu Gln Ala Ala Gln Thr Val Thr Gln Thr Ser Ala Asp Ala Ile 
        115                 120                 125             


Tyr Asp Cys Ser Ser Leu Tyr Gln Lys Asn Tyr Arg Ile Ser Gly Val 
    130                 135                 140                 


Tyr Lys Leu Pro Pro Asp Asp Phe Leu Gly Ser Pro Glu Leu Glu Val 
145                 150                 155                 160 


Phe Cys Asp Met Glu Thr Ser Gly Gly Gly Trp Thr Ile Ile Gln Arg 
                165                 170                 175     


Arg Lys Ser Gly Leu Val Ser Phe Tyr Arg Asp Trp Lys Gln Tyr Lys 
            180                 185                 190         


Gln Gly Phe Gly Ser Ile Arg Gly Asp Phe Trp Leu Gly Asn Glu His 
        195                 200                 205             


Ile His Arg Leu Ser Arg Gln Pro Thr Arg Leu Arg Val Glu Met Glu 
    210                 215                 220                 


Asp Trp Glu Gly Asn Leu Arg Tyr Ala Glu Tyr Ser His Phe Val Leu 
225                 230                 235                 240 


Gly Asn Glu Leu Asn Ser Tyr Arg Leu Phe Leu Gly Asn Tyr Thr Gly 
                245                 250                 255     


Asn Val Gly Asn Asp Ala Leu Gln Tyr His Asn Asn Thr Ala Phe Ser 
            260                 265                 270         


Thr Lys Asp Lys Asp Asn Asp Asn Cys Leu Asp Lys Cys Ala Gln Leu 
        275                 280                 285             


Arg Lys Gly Gly Tyr Trp Tyr Asn Cys Cys Thr Asp Ser Asn Leu Asn 
    290                 295                 300                 


Gly Val Tyr Tyr Arg Leu Gly Glu His Asn Lys His Leu Asp Gly Ile 
305                 310                 315                 320 


Thr Trp Tyr Gly Trp His Gly Ser Thr Tyr Ser Leu Lys Arg Val Glu 
                325                 330                 335     


Met Lys Ile Arg Pro Glu Asp Phe Lys Pro 
            340                 345     


<210>  11
<211>  176
<212>  PRT
<213>  homo sapien

<400>  11

Met Leu Lys Lys Pro Leu Ser Ala Val Thr Trp Leu Cys Ile Phe Ile 
1               5                   10                  15      


Val Ala Phe Val Ser His Pro Ala Trp Leu Gln Lys Leu Ser Lys His 
            20                  25                  30          


Lys Thr Pro Ala Gln Pro Gln Leu Lys Ala Ala Asn Cys Cys Glu Glu 
        35                  40                  45              


Val Lys Glu Leu Lys Ala Gln Val Ala Asn Leu Ser Ser Leu Leu Ser 
    50                  55                  60                  


Glu Leu Asn Lys Lys Gln Glu Arg Asp Trp Val Ser Val Val Met Gln 
65                  70                  75                  80  


Val Met Glu Leu Glu Ser Asn Ser Lys Arg Met Glu Ser Arg Leu Thr 
                85                  90                  95      


Asp Ala Glu Ser Lys Tyr Ser Glu Met Asn Asn Gln Ile Asp Ile Met 
            100                 105                 110         


Gln Leu Gln Ala Ala Gln Thr Val Thr Gln Thr Ser Ala Asp Ala Ile 
        115                 120                 125             


Tyr Asp Cys Ser Ser Leu Tyr Gln Lys Asn Tyr Arg Ile Ser Gly Val 
    130                 135                 140                 


Tyr Lys Leu Pro Pro Asp Asp Phe Leu Gly Ser Pro Glu Leu Glu Val 
145                 150                 155                 160 


Phe Cys Asp Met Glu Thr Ser Gly Gly Gly Trp Thr Ile Ile Gln Arg 
                165                 170                 175     


<210>  12
<211>  346
<212>  PRT
<213>  homo sapien

<400>  12

Met Leu Lys Lys Pro Leu Ser Ala Val Thr Trp Leu Cys Ile Phe Ile 
1               5                   10                  15      


Val Ala Phe Val Ser His Pro Ala Trp Leu Gln Lys Leu Ser Lys His 
            20                  25                  30          


Lys Thr Pro Ala Gln Pro Gln Leu Lys Ala Ala Asn Cys Cys Glu Glu 
        35                  40                  45              


Val Lys Glu Leu Lys Ala Gln Val Ala Asn Leu Ser Ser Leu Leu Ser 
    50                  55                  60                  


Glu Leu Asn Lys Lys Gln Glu Arg Asp Trp Val Ser Val Val Met Gln 
65                  70                  75                  80  


Val Met Glu Leu Glu Ser Asn Ser Lys Arg Met Glu Ser Arg Leu Thr 
                85                  90                  95      


Asp Ala Glu Ser Lys Tyr Ser Glu Met Asn Asn Gln Ile Asp Ile Met 
            100                 105                 110         


Gln Leu Gln Ala Ala Gln Thr Val Thr Gln Thr Ser Ala Asp Ala Ile 
        115                 120                 125             


Tyr Asp Cys Ser Ser Leu Tyr Gln Lys Asn Tyr Arg Ile Ser Gly Val 
    130                 135                 140                 


Tyr Lys Leu Pro Pro Asp Asp Phe Leu Gly Ser Pro Glu Leu Glu Val 
145                 150                 155                 160 


Phe Cys Asp Met Glu Thr Ser Gly Gly Gly Trp Thr Ile Ile His Arg 
                165                 170                 175     


Arg Lys Ser Gly Leu Val Ser Phe Tyr Arg Asp Trp Lys Gln Tyr Lys 
            180                 185                 190         


Gln Gly Phe Gly Ser Ile Arg Gly Asp Phe Trp Leu Gly Asn Glu His 
        195                 200                 205             


Ile His Arg Leu Ser Arg Gln Pro Thr Arg Leu Arg Val Glu Met Glu 
    210                 215                 220                 


Asp Trp Glu Gly Asn Leu Arg Tyr Ala Glu Tyr Ser His Phe Val Leu 
225                 230                 235                 240 


Gly Asn Glu Leu Asn Ser Tyr Arg Leu Phe Leu Gly Asn Tyr Thr Gly 
                245                 250                 255     


Asn Val Gly Asn Asp Ala Leu Gln Tyr His Asn Asn Thr Ala Phe Ser 
            260                 265                 270         


Thr Lys Asp Lys Asp Asn Asp Asn Cys Leu Asp Lys Cys Ala Gln Leu 
        275                 280                 285             


Arg Lys Gly Gly Tyr Trp Tyr Asn Cys Cys Thr Asp Ser Asn Leu Asn 
    290                 295                 300                 


Gly Val Tyr Tyr Arg Leu Gly Glu His Asn Lys His Leu Asp Gly Ile 
305                 310                 315                 320 


Thr Trp Tyr Gly Trp His Gly Ser Thr Tyr Ser Leu Lys Arg Val Glu 
                325                 330                 335     


Met Lys Ile Arg Pro Glu Asp Phe Lys Pro 
            340                 345     


<210>  13
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  13
ctgcagggac aggaacaggt tgg                                               23


<210>  14
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  14
cagagtatcc cctctgcttc agg                                               23


<210>  15
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  GGCTCTGCAGGGACAGGAACAGG

<400>  15
ggctctgcag ggacaggaac agg                                               23


<210>  16
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  16
gcttcaggtg ttctgtgaca tgg                                               23


<210>  17
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  17
tgcagggaca ggaacaggtt ggg                                               23


<210>  18
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  18
tctactggct ctgcagggac agg                                               23


<210>  19
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  19
ccttctaccg ggactggaag cag                                               23


<210>  20
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  20
ccgtggggac ttctggctgg gga                                               23


<210>  21
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  21
ccgggactgg aagcagtaca agc                                               23


<210>  22
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  22
ccttgtctcc ttctaccggg act                                               23


<210>  23
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  23
ccaccggctc tccagacagc caa                                               23


<210>  24
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  24
ccggctctcc agacagccaa ccc                                               23


<210>  25
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  25
tggagacttc aggcggaggc tgg                                               23


<210>  26
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  26
tgtgacatgg agacttcagg cgg                                               23


<210>  27
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  27
ttctgtgaca tggagacttc agg                                               23


<210>  28
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  28
gacatggaga cttcaggcgg agg                                               23


<210>  29
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  29
ccatgactgg accagtgcca cca                                               23


<210>  30
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  30
cccggctgcg tgtagagatg gag                                               23


<210>  31
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  31
ccggctgcgt gtagagatgg agg                                               23


<210>  32
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  32
ccaacccggc tgcgtgtaga gat                                               23


<210>  33
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  33
ccaggggccc catgactgga cca                                               23


<210>  34
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  34
ccccatgact ggaccagtgc cac                                               23


<210>  35
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  35
ctgcttccag tcccggtaga agg                                               23


<210>  36
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  36
ttgtctcctt ctaccgggac tgg                                               23


<210>  37
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  37
gcgggagtgc acacatctac tgg                                               23


<210>  38
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  38
ggactggaag cagtacaagc agg                                               23


<210>  39
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  39
gtggccttgt ctccttctac cgg                                               23


<210>  40
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  40
tactctggtg agggacttgc agg                                               23


<210>  41
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  41
actctggtga gggacttgca ggg                                               23


<210>  42
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  42
gcttgtactg cttccagtcc cgg                                               23


<210>  43
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  43
agtcccggta gaaggagaca agg                                               23


<210>  44
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  44
cacacatcta ctggctctgc agg                                               23


<210>  45
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  45
caaggccact ttttcgtcta tgg                                               23


<210>  46
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  46
gactggaagc agtacaagca ggg                                               23


<210>  47
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  47
gcagagggga tactctggtg agg                                               23


<210>  48
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  48
ctctggtgag ggacttgcag ggg                                               23


<210>  49
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  49
cagaggggat actctggtga ggg                                               23


<210>  50
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  50
actttttcgt ctatggatga tgg                                               23


<210>  51
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  51
tggccttgtc tccttctacc ggg                                               23


<210>  52
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  52
aagcagtaca agcagggctt tgg                                               23


<210>  53
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  53
ctgaagcaga ggggatactc tgg                                               23


<210>  54
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  54
tcacagaaca cctgaagcag agg                                               23


<210>  55
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  55
acacatctac tggctctgca ggg                                               23


<210>  56
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  56
atcatccata gacgaaaaag tgg                                               23


<210>  57
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  57
atgaccgcgt acaactccgg ggg                                               23


<210>  58
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  58
catgaccgcg tacaactccg ggg                                               23


<210>  59
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  59
ggcacccccg gagttgtacg cgg                                               23


<210>  60
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  60
gagttgtacg cggtcatgtg tgg                                               23


<210>  61
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  61
acatgaccgc gtacaactcc ggg                                               23


<210>  62
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  62
cacatgaccg cgtacaactc cgg                                               23


<210>  63
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  63
ttgtacgcgg tcatgtgtgg tgg                                               23


<210>  64
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  64
tggggaacga acacatccac cgg                                               23


<210>  65
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  65
ggtggcactg gtccagtcat ggg                                               23


<210>  66
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  66
cagaatagga atggcacccc cgg                                               23


<210>  67
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  67
gtggcactgg tccagtcatg ggg                                               23


<210>  68
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  68
gcggtcatgt gtggtggcac tgg                                               23


<210>  69
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  69
tggtggcact ggtccagtca tgg                                               23


<210>  70
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  70
gcagcatccg tggggacttc tgg                                               23


<210>  71
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  71
catccgtggg gacttctggc tgg                                               23


<210>  72
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  72
ggctctccag acagccaacc cgg                                               23


<210>  73
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  73
atccgtgggg acttctggct ggg                                               23


<210>  74
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  74
ttggctgtct ggagagccgg tgg                                               23


<210>  75
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  75
tggtccagtc atggggcccc tgg                                               23


<210>  76
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  76
gatttgtctt gaatcagaat agg                                               23


<210>  77
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  77
aacccggctg catgtagaga tgg                                               23


<210>  78
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  78
ctccatctct acatgcagcc ggg                                               23


<210>  79
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  79
tagagatgga ggtaagcaca agg                                               23


<210>  80
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  80
tccgtgggga cttctggctg ggg                                               23


<210>  81
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  81
atctctacac acagccgggt tgg                                               23


<210>  82
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  82
aacccggctg tgtgtagaga tgg                                               23


<210>  83
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  83
cctccatctc tacacacagc cgg                                               23


<210>  84
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  84
caatggagtg tactaccgcc tgg                                               23


<210>  85
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  85
aatggagtgt actaccgcct ggg                                               23


<210>  86
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  86
tacctactcc ctcaaacggg tgg                                               23


<210>  87
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  87
tttcatctcc acccgtttga ggg                                               23


<210>  88
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  88
acagtcaact tactagcact ggg                                               23


<210>  89
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  89
ttttcatctc cacccgtttg agg                                               23


<210>  90
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  90
gggtgagcac aataagcacc tgg                                               23


<210>  91
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  91
atggcatcac ctggtatggc tgg                                               23


<210>  92
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  92
ctccacccgt ttgagggagt agg                                               23


<210>  93
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  93
ggtgcttatt gtgctcaccc agg                                               23


<210>  94
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  94
ctaactcctt acctgatgtc tgg                                               23


<210>  95
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  95
cacagtcaac ttactagcac tgg                                               23


<210>  96
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  96
cagttgtacc agtagccacc tgg                                               23


<210>  97
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  97
gatagaccag acatcaggta agg                                               23


<210>  98
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  98
tcaggtaagg agttagagcc agg                                               23


<210>  99
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  99
gatctaccta ctccctcaaa cgg                                               23


<210>  100
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  100
agatccatgc cagccatacc agg                                               23


<210>  101
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  101
gcttattgtg ctcacccagg cgg                                               23


<210>  102
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  102
cataccaggt gatgccatcc agg                                               23


<210>  103
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  103
atctacctac tccctcaaac ggg                                               23


<210>  104
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  104
actgtgatag accagacatc agg                                               23


<210>  105
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  105
ttctcatgcc aggtggctac tgg                                               23


<210>  106
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  106
ctggatggca tcacctggta tgg                                               23


<210>  107
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  107
agcacctgga tggcatcacc tgg                                               23


<210>  108
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  108
atcacctggt atggctggca tgg                                               23


<210>  109
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  109
gtagtacact ccattgagtt tgg                                               23


<210>  110
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  110
gagcacaata agcacctgga tgg                                               23


<210>  111
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  111
caggtaagga gttagagcca ggg                                               23


<210>  112
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  112
ctgggtctgt ttctcatgcc agg                                               23


<210>  113
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  113
tttggtattc tttctgaccc tgg                                               23


<210>  114
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  114
gtcagaaaga ataccaaaac cgg                                               23


<210>  115
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  115
ggtctgtttc tcatgccagg tgg                                               23


<210>  116
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  116
ggcggtagta cactccattg agg                                               23


<210>  117
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  117
gtagtacact ccattgaggt tgg                                               23


<210>  118
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  118
gtttctgtat ccgtgctcca cgg                                               23


<210>  119
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  119
aaactgagac acgtggagac tgg                                               23


<210>  120
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  120
gccttaaaag gaggctgccg tgg                                               23


<210>  121
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  121
gacacgtgga gactggatga ggg                                               23


<210>  122
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  122
tccacggcag cctcctttta agg                                               23


<210>  123
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  123
tgcacagact ccaacctcaa tgg                                               23


<210>  124
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  124
agacacgtgg agactggatg agg                                               23


<210>  125
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  125
agacttcaag ccttaaaagg agg                                               23


<210>  126
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  126
tttaaggctt gaagtcttct ggg                                               23


<210>  127
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  127
aaggcttgaa gtcttctggg tgg                                               23


<210>  128
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  128
ttttaaggct tgaagtcttc tgg                                               23


<210>  129
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  129
gatacagaaa ctgagacacg tgg                                               23


<210>  130
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  130
aaggaggctg ccgtggagca cgg                                               23


<210>  131
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  131
agaagacttc aagccttaaa agg                                               23


<210>  132
<211>  6641
<212>  DNA
<213>  homo sapien

<400>  132
cttgtggagc attcgggctt ggaaggaaag ctataggcta cccattcagc tcccctgtca       60

gagactcaag ctttgagaaa ggctagcaaa gagcaaggaa agagagaaaa caacaaagtg      120

gcgaggccct cagagtgaaa gcgtaaggtt cagtcagcct gctgcagctt tgcagacctc      180

agctgggcat ctccagactc ccctgaagga agagccttcc tcacccaaac ccacaaaaga      240

tgctgaaaaa gcctctctca gctgtgacct ggctctgcat tttcatcgtg gcctttgtca      300

gccacccagc gtggctgcag aagctctcta agcacaagac accagcacag ccacagctca      360

aagcggccaa ctgctgtgag gaggtgaagg agctcaaggc ccaagttgcc aaccttagca      420

gcctgctgag tgaactgaac aagaagcagg agagggactg ggtcagcgtg gtcatgcagg      480

tgatggagct ggagagcaac agcaagcgca tggagtcgcg gctcacagat gctgagagca      540

agtactccga gatgaacaac caaattgaca tcatgcagct gcaggcagca cagacggtca      600

ctcagacctc cgcaggtaag gagaccagtc ccctgaggga gcgtggagtg cctccccatc      660

tacagcactg cttctacata tcctggtcat cagaaccact actggggcct cttttgtggg      720

tacactttcc ctttagtaaa ggcttatgca gtatttcctt tgacttctaa tgctatgtaa      780

gtttacctaa caccttcacg ggtctctttt atccacacag tgtttcagcc taccatcttg      840

gagtgctgag atactacatg gtttgcccaa agtcacccag caagtcttag aagcagggtt      900

caagtcttcc tgattggtgt agctctgcta cttcctcacc aagagctgac aggctatatc      960

tcaagaaatt ccaaggaagc accaaactgt aacagctgtt cctctggaag caaagttttg     1020

ccagaaacag ttctctggtg ttcctaagat ttaccaggaa tgagcattaa tggaattttg     1080

tgtcctctct ctgtaaacgt aactcttctc attggctcag agttaagtgt agagacacat     1140

aaccatgtga agagtccctt tgtgttcagg aaggatgcgg ctccttaagg ttcctcaatt     1200

gtgatacgtc tatttttttc catggtctta aatgaatttc tccgaataca ggatttttta     1260

aatgcaatgc tgaaatatag acttaatagg ccaaaaataa gataaattta atctttcttt     1320

tgcaaaataa cttttatttc tggttagctc agctcaggtg ggccaacatg aatttacggt     1380

ttagagataa aaatttggtt ttctgaaatt atcaggaaaa tattagttgt aaggagcata     1440

tcctatagac atgtcatttc ttgctgatat aaaaaccatt ggtcccatta taaactacat     1500

gaagaacaaa gacatgatca gcttctactg actaagtcaa tggttaacct cagctcaaat     1560

taagaaaaag ttttaacatg aaaccaagct tgaaaattct gttacctgaa ccaacatgta     1620

tcaatcactt tctaagcatg gacttccggg ccctcagttt gggattagaa aggtattctc     1680

aggccatttt ccagacaagt gagtcctgat ttggtctgtg agatgaaacc agacatgcgg     1740

aagaccaggc cagacagagg aatctgaccg tgccacttcc tgctcatcca aacaggaggc     1800

tttctcacca tcctgcaagg aggttcttgg ggtcaagtgc agctctccca ccaggtctct     1860

tgctcttctt gcccaggaca tcattcctta tttttcttct ctatgaccaa gtgctcagtt     1920

acccttatat tctataagta ggtagtccct tagaggaagc agtaagttgg tgctttcacc     1980

actaagacga aatgaagaat agtgatggcg aaggcacacg tactctacct ccctttccca     2040

aggtgctctg caagagaacc tatgtgcctc agacaactcc catctgccat cttggtgctc     2100

ctctctaagg tcccagtgca gtggtcacca agaaaagcac cccgagacat agcaggcagg     2160

aagcttctct tggatagtaa gggccgcagt ctctgaatcc tatcagaaaa ggctgtctct     2220

tccactatgc tctttgatat ttagaataca gagcttaaat cctgcataaa gtagcagctc     2280

catggcccta gagtaaaaaa actggccagt ctgatgctct catttcattg ttttaacaaa     2340

acttctggga ggaaggcctc aaaggttctt ctgagtgttt tgaggtgcta gctggatgga     2400

aggggaaaat atgtgataat aaaatctatc tcccttaatt atggtctcag gtggcagtag     2460

ccaccatctc tgaacaacaa caaaaacaac caaccaggaa acatcaacaa aaccagactc     2520

tatgagatat tcacgactga tttgttatag tggcggctgt ctaagaagtc tgaatctatc     2580

tgacaggagt atctgttacg tggccctcat acactgtaac atttctagaa ttcatggccc     2640

agctatagca gaataattta tttcagagtt aacctgaaac cacctgttgg aacgtcccac     2700

taatgctatc caggtgaagg gcttccctac ccctctgctc caccgctagt aaagccaaaa     2760

tacaccccct ctggatctcc ccatatccac ctctcccaaa tgcagacact gatgggtaat     2820

taacaccact gagaatccca gggtagaaat aaaggctcag tctctaaaca ctcaactcag     2880

atggagccac tgggtctaaa tgctcaccct gtggtttgtt ctcttgtaga tgccatctac     2940

gactgctctt ccctctacca gaagaactac cgcatctctg gagtgtataa gcttcctcct     3000

gatgacttcc tgggcagccc tgaactggag gtgaggtcat tacagtcact ggccatgccc     3060

taatacctgt ccttcacccc ctcaagggga ctacaacaac agggccattc acagtttaaa     3120

gaaaggaaaa ttcggctggg cgcagtggct cacacctgta atcccagcac tatgggaggc     3180

cgaggcaggt ggatcacttc aggtcaggag tttaagacca gcctggccaa catggtgaaa     3240

ccctgtctct actaaaaata caaaaaaatt agccaggcat ggtggtgggc acctgtaatc     3300

cctgctacac aggaggattg cttgaactca ggaggcagag gttgcagtga gccgagatca     3360

cgccactgca ctataatctg ggagacaaag tgagactcca tttcaattaa aaaaaaaaaa     3420

aaaaaaaagg aaaactcaaa cacaagcaaa cacaccaaac accacagagc tatgcaaaca     3480

ctcagtttat gccctgcact ccaaacccag gcatctgttt ggccccttca aatcattatc     3540

agtcaaacaa caagccttct aacatagatc agatcattct tataaccacc acataactta     3600

gtttaaatct cttgccatgt cctagaacag ctattccttg ggggaggaga aaagaaaaca     3660

cgaaggcagc atcaaattat ctggattttc acccaggcat ggtggctcac acctgtaatc     3720

ccaagttttt tgggaggtga ggtgggcgga acaatcacct gaggtcagga ctttgagacc     3780

agcctggcca acatgctgaa acccagtctc tactaaaaat acaaaaatta gcccagtgtg     3840

gtgacaggca ctctggtccc agctactagg aaggcaggag aatcactgga actcaggagg     3900

tggaggttgc agtgagccga gattgcacca ctgtactcta gcctgggcaa caagagtgaa     3960

attctgcttc aaaaaaaaaa aaagtatctg gatttttccc tccaagcttc atgtgcactc     4020

acccccgggc ccaatttgca tcgttcttcc agagcaatgc accacccacc ccagctcacc     4080

agcagtgggg cagcatcact gcccgagtga gccagtgtga ctgcgggagt gcacacatct     4140

actggctctg cagggacagg aacaggttgg gaagcctgcc ctcttgctcc tgccttctgc     4200

ccctgcaagt ccctcaccag agtatcccct ctgcttcagg tgatctgtga catggagact     4260

tcaggcggag gctggaccat catccagaga cgaaaaagtg gccttgtctc cttctaccgg     4320

gactggaagc agtacaagca gggctttggc agcatccgtg gggacttctg gctggggaac     4380

gaacacatcc accggctctc cagacagcca acccggctgc gtgtagagat ggaggtaagc     4440

acaaggccag gggccccatg actggaccag tgccaccaca catgaccgcg tacaactccg     4500

ggggtgccat tcctattctg attcaagaca aatctgtata ttcattgtga tggttttcct     4560

gcaagttgta atggagttga ggaaaaatag gtatttttcc tttctgcaac ccccccaacc     4620

ccccgacaaa agtggggctg caggtgggac aggaagaggc cagacccagg ccagagtaga     4680

gcaaattcaa cagtcagctg tgccgaacac tagtctctgc tctggccgag catgaggtcc     4740

tttaggtgca aatcttactg atactgtttg gggacccttg ctgaaggtct gaaagcactc     4800

actatatcct catgtttctc ttacagcagc tctgtgtggg attcagcaaa aacatagctg     4860

caccttataa gcaggaaagt gaggaatata gaaagagaga ctaatcaagg ccatatggtg     4920

aatcaggaaa gaagttcgag ccttgttttc tgattcccag gttaacacag taaactggag     4980

gtaaacaagt aataaagtct tattagattc acacctataa aaagatgttt ggctatggga     5040

ctgtcaggag agaaggggta tagagacagc atgaaatgga gcctgctgca ctttctttaa     5100

ggctctgctc ctcctgacag gactgggagg gcaacctgcg ctacgctgag tatagccact     5160

ttgttttggg caatgaactc aacagctatc gcctcttcct ggggaactac actggcaatg     5220

tggggaacga cgccctccag tatcataaca acacagcctt cagcaccaag gacaaggaca     5280

atgacaactg cttggacaag tgtgcacagc tccgcaaagg tgagatttgg ggggaccgga     5340

aaggagaagt tcaggtacaa gctcataatc ccacttgagg agaaagagtg aattataact     5400

gtacagttga tattccggtt ttggtattct ttctgaccct ggctctaact ccttacctga     5460

tgtctggtct atcacagtca acttactagc actgggtctg tttctcatgc caggtggcta     5520

ctggtacaac tgctgcacag actccaacct caatggagtg tactaccgcc tgggtgagca     5580

caataagcac ctggatggca tcacctggta tggctggcat ggatctacct actccctcaa     5640

acgggtggag atgaaaatcc gcccagaaga cttcaagcct taaaaggagg ctgccgtgga     5700

gcacggatac agaaactgag acacgtggag actggatgag ggcagatgag gacaggaaga     5760

gagtgttaga aagggtagga ctgagaaaca gcctataatc tccaaagaaa gaataagtct     5820

ccaaggagca caaaaaaatc atatgtacca aggatgttac agtaaacagg atgaactatt     5880

taaacccact gggtcctgcc acatccttct caaggtggta gactgagtgg ggtctctctg     5940

cccaagatcc ctgacatagc agtagcttgt cttttccaca tgatttgtct gtgaaagaaa     6000

ataattttga gatcgtttta tctattttct ctacggctta ggctatgtga gggcaaaaca     6060

caaatccctt tgctaaaaag aaccatatta ttttgattct caaaggatag gcctttgagt     6120

gttagagaaa ggagtgaagg aggcaggtgg gaaatggtat ttctattttt aaatccagtg     6180

aaattatctt gagtctacac attattttta aaacacaaaa attgttcggc tggaactgac     6240

ccaggctgga cttgcgggga ggaaactcca gggcactgca tctggcgatc agactctgag     6300

cactgcccct gctcgccttg gtcatgtaca gcactgaaag gaatgaagca ccagcaggag     6360

gtggacagag tctctcatgg atgccggcac aaaactgcct taaaatattc atagttaata     6420

caggtatatc tatttttatt tactttgtaa gaaacaagct caaggagctt ccttttaaat     6480

tttgtctgta ggaaatggtt gaaaactgaa ggtagatggt gttatagtta ataataaatg     6540

ctgtaaataa gcatctcact ttgtaaaaat aaaatattgt ggttttgttt taaacattca     6600

acgtttcttt tccttctaca ataaacactt tcaaaatgtg a                         6641


<210>  133
<211>  6641
<212>  DNA
<213>  homo sapien

<400>  133
cttgtggagc attcgggctt ggaaggaaag ctataggcta cccattcagc tcccctgtca       60

gagactcaag ctttgagaaa ggctagcaaa gagcaaggaa agagagaaaa caacaaagtg      120

gcgaggccct cagagtgaaa gcgtaaggtt cagtcagcct gctgcagctt tgcagacctc      180

agctgggcat ctccagactc ccctgaagga agagccttcc tcacccaaac ccacaaaaga      240

tgctgaaaaa gcctctctca gctgtgacct ggctctgcat tttcatcgtg gcctttgtca      300

gccacccagc gtggctgcag aagctctcta agcacaagac accagcacag ccacagctca      360

aagcggccaa ctgctgtgag gaggtgaagg agctcaaggc ccaagttgcc aaccttagca      420

gcctgctgag tgaactgaac aagaagcagg agagggactg ggtcagcgtg gtcatgcagg      480

tgatggagct ggagagcaac agcaagcgca tggagtcgcg gctcacagat gctgagagca      540

agtactccga gatgaacaac caaattgaca tcatgcagct gcaggcagca cagacggtca      600

ctcagacctc cgcaggtaag gagaccagtc ccctgaggga gcgtggagtg cctccccatc      660

tacagcactg cttctacata tcctggtcat cagaaccact actggggcct cttttgtggg      720

tacactttcc ctttagtaaa ggcttatgca gtatttcctt tgacttctaa tgctatgtaa      780

gtttacctaa caccttcacg ggtctctttt atccacacag tgtttcagcc taccatcttg      840

gagtgctgag atactacatg gtttgcccaa agtcacccag caagtcttag aagcagggtt      900

caagtcttcc tgattggtgt agctctgcta cttcctcacc aagagctgac aggctatatc      960

tcaagaaatt ccaaggaagc accaaactgt aacagctgtt cctctggaag caaagttttg     1020

ccagaaacag ttctctggtg ttcctaagat ttaccaggaa tgagcattaa tggaattttg     1080

tgtcctctct ctgtaaacgt aactcttctc attggctcag agttaagtgt agagacacat     1140

aaccatgtga agagtccctt tgtgttcagg aaggatgcgg ctccttaagg ttcctcaatt     1200

gtgatacgtc tatttttttc catggtctta aatgaatttc tccgaataca ggatttttta     1260

aatgcaatgc tgaaatatag acttaatagg ccaaaaataa gataaattta atctttcttt     1320

tgcaaaataa cttttatttc tggttagctc agctcaggtg ggccaacatg aatttacggt     1380

ttagagataa aaatttggtt ttctgaaatt atcaggaaaa tattagttgt aaggagcata     1440

tcctatagac atgtcatttc ttgctgatat aaaaaccatt ggtcccatta taaactacat     1500

gaagaacaaa gacatgatca gcttctactg actaagtcaa tggttaacct cagctcaaat     1560

taagaaaaag ttttaacatg aaaccaagct tgaaaattct gttacctgaa ccaacatgta     1620

tcaatcactt tctaagcatg gacttccggg ccctcagttt gggattagaa aggtattctc     1680

aggccatttt ccagacaagt gagtcctgat ttggtctgtg agatgaaacc agacatgcgg     1740

aagaccaggc cagacagagg aatctgaccg tgccacttcc tgctcatcca aacaggaggc     1800

tttctcacca tcctgcaagg aggttcttgg ggtcaagtgc agctctccca ccaggtctct     1860

tgctcttctt gcccaggaca tcattcctta tttttcttct ctatgaccaa gtgctcagtt     1920

acccttatat tctataagta ggtagtccct tagaggaagc agtaagttgg tgctttcacc     1980

actaagacga aatgaagaat agtgatggcg aaggcacacg tactctacct ccctttccca     2040

aggtgctctg caagagaacc tatgtgcctc agacaactcc catctgccat cttggtgctc     2100

ctctctaagg tcccagtgca gtggtcacca agaaaagcac cccgagacat agcaggcagg     2160

aagcttctct tggatagtaa gggccgcagt ctctgaatcc tatcagaaaa ggctgtctct     2220

tccactatgc tctttgatat ttagaataca gagcttaaat cctgcataaa gtagcagctc     2280

catggcccta gagtaaaaaa actggccagt ctgatgctct catttcattg ttttaacaaa     2340

acttctggga ggaaggcctc aaaggttctt ctgagtgttt tgaggtgcta gctggatgga     2400

aggggaaaat atgtgataat aaaatctatc tcccttaatt atggtctcag gtggcagtag     2460

ccaccatctc tgaacaacaa caaaaacaac caaccaggaa acatcaacaa aaccagactc     2520

tatgagatat tcacgactga tttgttatag tggcggctgt ctaagaagtc tgaatctatc     2580

tgacaggagt atctgttacg tggccctcat acactgtaac atttctagaa ttcatggccc     2640

agctatagca gaataattta tttcagagtt aacctgaaac cacctgttgg aacgtcccac     2700

taatgctatc caggtgaagg gcttccctac ccctctgctc caccgctagt aaagccaaaa     2760

tacaccccct ctggatctcc ccatatccac ctctcccaaa tgcagacact gatgggtaat     2820

taacaccact gagaatccca gggtagaaat aaaggctcag tctctaaaca ctcaactcag     2880

atggagccac tgggtctaaa tgctcaccct gtggtttgtt ctcttgtaga tgccatctac     2940

gactgctctt ccctctacca gaagaactac cgcatctctg gagtgtataa gcttcctcct     3000

gatgacttcc tgggcagccc tgaactggag gtgaggtcat tacagtcact ggccatgccc     3060

taatacctgt ccttcacccc ctcaagggga ctacaacaac agggccattc acagtttaaa     3120

gaaaggaaaa ttcggctggg cgcagtggct cacacctgta atcccagcac tatgggaggc     3180

cgaggcaggt ggatcacttc aggtcaggag tttaagacca gcctggccaa catggtgaaa     3240

ccctgtctct actaaaaata caaaaaaatt agccaggcat ggtggtgggc acctgtaatc     3300

cctgctacac aggaggattg cttgaactca ggaggcagag gttgcagtga gccgagatca     3360

cgccactgca ctataatctg ggagacaaag tgagactcca tttcaattaa aaaaaaaaaa     3420

aaaaaaaagg aaaactcaaa cacaagcaaa cacaccaaac accacagagc tatgcaaaca     3480

ctcagtttat gccctgcact ccaaacccag gcatctgttt ggccccttca aatcattatc     3540

agtcaaacaa caagccttct aacatagatc agatcattct tataaccacc acataactta     3600

gtttaaatct cttgccatgt cctagaacag ctattccttg ggggaggaga aaagaaaaca     3660

cgaaggcagc atcaaattat ctggattttc acccaggcat ggtggctcac acctgtaatc     3720

ccaagttttt tgggaggtga ggtgggcgga acaatcacct gaggtcagga ctttgagacc     3780

agcctggcca acatgctgaa acccagtctc tactaaaaat acaaaaatta gcccagtgtg     3840

gtgacaggca ctctggtccc agctactagg aaggcaggag aatcactgga actcaggagg     3900

tggaggttgc agtgagccga gattgcacca ctgtactcta gcctgggcaa caagagtgaa     3960

attctgcttc aaaaaaaaaa aaagtatctg gatttttccc tccaagcttc atgtgcactc     4020

acccccgggc ccaatttgca tcgttcttcc agagcaatgc accacccacc ccagctcacc     4080

agcagtgggg cagcatcact gcccgagtga gccagtgtga ctgcgggagt gcacacatct     4140

actggctctg cagggacagg aacaggttgg gaagcctgcc ctcttgctcc tgccttctgc     4200

ccctgcaagt ccctcaccag agtatcccct ctgcttcagg tgttctgtga catggagact     4260

tcaggcggag gctggaccat catccagaga cgaaaaagtg gccttgtctc cttctaccgg     4320

gactagaagc agtacaagca gggctttggc agcatccgtg gggacttctg gctggggaac     4380

gaacacatcc accggctctc cagacagcca acccggctgc gtgtagagat ggaggtaagc     4440

acaaggccag gggccccatg actggaccag tgccaccaca catgaccgcg tacaactccg     4500

ggggtgccat tcctattctg attcaagaca aatctgtata ttcattgtga tggttttcct     4560

gcaagttgta atggagttga ggaaaaatag gtatttttcc tttctgcaac ccccccaacc     4620

ccccgacaaa agtggggctg caggtgggac aggaagaggc cagacccagg ccagagtaga     4680

gcaaattcaa cagtcagctg tgccgaacac tagtctctgc tctggccgag catgaggtcc     4740

tttaggtgca aatcttactg atactgtttg gggacccttg ctgaaggtct gaaagcactc     4800

actatatcct catgtttctc ttacagcagc tctgtgtggg attcagcaaa aacatagctg     4860

caccttataa gcaggaaagt gaggaatata gaaagagaga ctaatcaagg ccatatggtg     4920

aatcaggaaa gaagttcgag ccttgttttc tgattcccag gttaacacag taaactggag     4980

gtaaacaagt aataaagtct tattagattc acacctataa aaagatgttt ggctatggga     5040

ctgtcaggag agaaggggta tagagacagc atgaaatgga gcctgctgca ctttctttaa     5100

ggctctgctc ctcctgacag gactgggagg gcaacctgcg ctacgctgag tatagccact     5160

ttgttttggg caatgaactc aacagctatc gcctcttcct ggggaactac actggcaatg     5220

tggggaacga cgccctccag tatcataaca acacagcctt cagcaccaag gacaaggaca     5280

atgacaactg cttggacaag tgtgcacagc tccgcaaagg tgagatttgg ggggaccgga     5340

aaggagaagt tcaggtacaa gctcataatc ccacttgagg agaaagagtg aattataact     5400

gtacagttga tattccggtt ttggtattct ttctgaccct ggctctaact ccttacctga     5460

tgtctggtct atcacagtca acttactagc actgggtctg tttctcatgc caggtggcta     5520

ctggtacaac tgctgcacag actccaacct caatggagtg tactaccgcc tgggtgagca     5580

caataagcac ctggatggca tcacctggta tggctggcat ggatctacct actccctcaa     5640

acgggtggag atgaaaatcc gcccagaaga cttcaagcct taaaaggagg ctgccgtgga     5700

gcacggatac agaaactgag acacgtggag actggatgag ggcagatgag gacaggaaga     5760

gagtgttaga aagggtagga ctgagaaaca gcctataatc tccaaagaaa gaataagtct     5820

ccaaggagca caaaaaaatc atatgtacca aggatgttac agtaaacagg atgaactatt     5880

taaacccact gggtcctgcc acatccttct caaggtggta gactgagtgg ggtctctctg     5940

cccaagatcc ctgacatagc agtagcttgt cttttccaca tgatttgtct gtgaaagaaa     6000

ataattttga gatcgtttta tctattttct ctacggctta ggctatgtga gggcaaaaca     6060

caaatccctt tgctaaaaag aaccatatta ttttgattct caaaggatag gcctttgagt     6120

gttagagaaa ggagtgaagg aggcaggtgg gaaatggtat ttctattttt aaatccagtg     6180

aaattatctt gagtctacac attattttta aaacacaaaa attgttcggc tggaactgac     6240

ccaggctgga cttgcgggga ggaaactcca gggcactgca tctggcgatc agactctgag     6300

cactgcccct gctcgccttg gtcatgtaca gcactgaaag gaatgaagca ccagcaggag     6360

gtggacagag tctctcatgg atgccggcac aaaactgcct taaaatattc atagttaata     6420

caggtatatc tatttttatt tactttgtaa gaaacaagct caaggagctt ccttttaaat     6480

tttgtctgta ggaaatggtt gaaaactgaa ggtagatggt gttatagtta ataataaatg     6540

ctgtaaataa gcatctcact ttgtaaaaat aaaatattgt ggttttgttt taaacattca     6600

acgtttcttt tccttctaca ataaacactt tcaaaatgtg a                         6641


<210>  134
<211>  6641
<212>  DNA
<213>  homo sapien

<400>  134
cttgtggagc attcgggctt ggaaggaaag ctataggcta cccattcagc tcccctgtca       60

gagactcaag ctttgagaaa ggctagcaaa gagcaaggaa agagagaaaa caacaaagtg      120

gcgaggccct cagagtgaaa gcgtaaggtt cagtcagcct gctgcagctt tgcagacctc      180

agctgggcat ctccagactc ccctgaagga agagccttcc tcacccaaac ccacaaaaga      240

tgctgaaaaa gcctctctca gctgtgacct ggctctgcat tttcatcgtg gcctttgtca      300

gccacccagc gtggctgcag aagctctcta agcacaagac accagcacag ccacagctca      360

aagcggccaa ctgctgtgag gaggtgaagg agctcaaggc ccaagttgcc aaccttagca      420

gcctgctgag tgaactgaac aagaagcagg agagggactg ggtcagcgtg gtcatgcagg      480

tgatggagct ggagagcaac agcaagcgca tggagtcgcg gctcacagat gctgagagca      540

agtactccga gatgaacaac caaattgaca tcatgcagct gcaggcagca cagacggtca      600

ctcagacctc cgcaggtaag gagaccagtc ccctgaggga gcgtggagtg cctccccatc      660

tacagcactg cttctacata tcctggtcat cagaaccact actggggcct cttttgtggg      720

tacactttcc ctttagtaaa ggcttatgca gtatttcctt tgacttctaa tgctatgtaa      780

gtttacctaa caccttcacg ggtctctttt atccacacag tgtttcagcc taccatcttg      840

gagtgctgag atactacatg gtttgcccaa agtcacccag caagtcttag aagcagggtt      900

caagtcttcc tgattggtgt agctctgcta cttcctcacc aagagctgac aggctatatc      960

tcaagaaatt ccaaggaagc accaaactgt aacagctgtt cctctggaag caaagttttg     1020

ccagaaacag ttctctggtg ttcctaagat ttaccaggaa tgagcattaa tggaattttg     1080

tgtcctctct ctgtaaacgt aactcttctc attggctcag agttaagtgt agagacacat     1140

aaccatgtga agagtccctt tgtgttcagg aaggatgcgg ctccttaagg ttcctcaatt     1200

gtgatacgtc tatttttttc catggtctta aatgaatttc tccgaataca ggatttttta     1260

aatgcaatgc tgaaatatag acttaatagg ccaaaaataa gataaattta atctttcttt     1320

tgcaaaataa cttttatttc tggttagctc agctcaggtg ggccaacatg aatttacggt     1380

ttagagataa aaatttggtt ttctgaaatt atcaggaaaa tattagttgt aaggagcata     1440

tcctatagac atgtcatttc ttgctgatat aaaaaccatt ggtcccatta taaactacat     1500

gaagaacaaa gacatgatca gcttctactg actaagtcaa tggttaacct cagctcaaat     1560

taagaaaaag ttttaacatg aaaccaagct tgaaaattct gttacctgaa ccaacatgta     1620

tcaatcactt tctaagcatg gacttccggg ccctcagttt gggattagaa aggtattctc     1680

aggccatttt ccagacaagt gagtcctgat ttggtctgtg agatgaaacc agacatgcgg     1740

aagaccaggc cagacagagg aatctgaccg tgccacttcc tgctcatcca aacaggaggc     1800

tttctcacca tcctgcaagg aggttcttgg ggtcaagtgc agctctccca ccaggtctct     1860

tgctcttctt gcccaggaca tcattcctta tttttcttct ctatgaccaa gtgctcagtt     1920

acccttatat tctataagta ggtagtccct tagaggaagc agtaagttgg tgctttcacc     1980

actaagacga aatgaagaat agtgatggcg aaggcacacg tactctacct ccctttccca     2040

aggtgctctg caagagaacc tatgtgcctc agacaactcc catctgccat cttggtgctc     2100

ctctctaagg tcccagtgca gtggtcacca agaaaagcac cccgagacat agcaggcagg     2160

aagcttctct tggatagtaa gggccgcagt ctctgaatcc tatcagaaaa ggctgtctct     2220

tccactatgc tctttgatat ttagaataca gagcttaaat cctgcataaa gtagcagctc     2280

catggcccta gagtaaaaaa actggccagt ctgatgctct catttcattg ttttaacaaa     2340

acttctggga ggaaggcctc aaaggttctt ctgagtgttt tgaggtgcta gctggatgga     2400

aggggaaaat atgtgataat aaaatctatc tcccttaatt atggtctcag gtggcagtag     2460

ccaccatctc tgaacaacaa caaaaacaac caaccaggaa acatcaacaa aaccagactc     2520

tatgagatat tcacgactga tttgttatag tggcggctgt ctaagaagtc tgaatctatc     2580

tgacaggagt atctgttacg tggccctcat acactgtaac atttctagaa ttcatggccc     2640

agctatagca gaataattta tttcagagtt aacctgaaac cacctgttgg aacgtcccac     2700

taatgctatc caggtgaagg gcttccctac ccctctgctc caccgctagt aaagccaaaa     2760

tacaccccct ctggatctcc ccatatccac ctctcccaaa tgcagacact gatgggtaat     2820

taacaccact gagaatccca gggtagaaat aaaggctcag tctctaaaca ctcaactcag     2880

atggagccac tgggtctaaa tgctcaccct gtggtttgtt ctcttgtaga tgccatctac     2940

gactgctctt ccctctacca gaagaactac cgcatctctg gagtgtataa gcttcctcct     3000

gatgacttcc tgggcagccc tgaactggag gtgaggtcat tacagtcact ggccatgccc     3060

taatacctgt ccttcacccc ctcaagggga ctacaacaac agggccattc acagtttaaa     3120

gaaaggaaaa ttcggctggg cgcagtggct cacacctgta atcccagcac tatgggaggc     3180

cgaggcaggt ggatcacttc aggtcaggag tttaagacca gcctggccaa catggtgaaa     3240

ccctgtctct actaaaaata caaaaaaatt agccaggcat ggtggtgggc acctgtaatc     3300

cctgctacac aggaggattg cttgaactca ggaggcagag gttgcagtga gccgagatca     3360

cgccactgca ctataatctg ggagacaaag tgagactcca tttcaattaa aaaaaaaaaa     3420

aaaaaaaagg aaaactcaaa cacaagcaaa cacaccaaac accacagagc tatgcaaaca     3480

ctcagtttat gccctgcact ccaaacccag gcatctgttt ggccccttca aatcattatc     3540

agtcaaacaa caagccttct aacatagatc agatcattct tataaccacc acataactta     3600

gtttaaatct cttgccatgt cctagaacag ctattccttg ggggaggaga aaagaaaaca     3660

cgaaggcagc atcaaattat ctggattttc acccaggcat ggtggctcac acctgtaatc     3720

ccaagttttt tgggaggtga ggtgggcgga acaatcacct gaggtcagga ctttgagacc     3780

agcctggcca acatgctgaa acccagtctc tactaaaaat acaaaaatta gcccagtgtg     3840

gtgacaggca ctctggtccc agctactagg aaggcaggag aatcactgga actcaggagg     3900

tggaggttgc agtgagccga gattgcacca ctgtactcta gcctgggcaa caagagtgaa     3960

attctgcttc aaaaaaaaaa aaagtatctg gatttttccc tccaagcttc atgtgcactc     4020

acccccgggc ccaatttgca tcgttcttcc agagcaatgc accacccacc ccagctcacc     4080

agcagtgggg cagcatcact gcccgagtga gccagtgtga ctgcgggagt gcacacatct     4140

actggctctg cagggacagg aacaggttgg gaagcctgcc ctcttgctcc tgccttctgc     4200

ccctgcaagt ccctcaccag agtatcccct ctgcttcagg tgttctgtga catggagact     4260

tcaggcggag gctggaccat catccagaga cgaaaaagtg gccttgtctc cttctaccgg     4320

gactggaagc agtaccagca gggctttggc agcatccgtg gggacttctg gctggggaac     4380

gaacacatcc accggctctc cagacagcca acccggctgc gtgtagagat ggaggtaagc     4440

acaaggccag gggccccatg actggaccag tgccaccaca catgaccgcg tacaactccg     4500

ggggtgccat tcctattctg attcaagaca aatctgtata ttcattgtga tggttttcct     4560

gcaagttgta atggagttga ggaaaaatag gtatttttcc tttctgcaac ccccccaacc     4620

ccccgacaaa agtggggctg caggtgggac aggaagaggc cagacccagg ccagagtaga     4680

gcaaattcaa cagtcagctg tgccgaacac tagtctctgc tctggccgag catgaggtcc     4740

tttaggtgca aatcttactg atactgtttg gggacccttg ctgaaggtct gaaagcactc     4800

actatatcct catgtttctc ttacagcagc tctgtgtggg attcagcaaa aacatagctg     4860

caccttataa gcaggaaagt gaggaatata gaaagagaga ctaatcaagg ccatatggtg     4920

aatcaggaaa gaagttcgag ccttgttttc tgattcccag gttaacacag taaactggag     4980

gtaaacaagt aataaagtct tattagattc acacctataa aaagatgttt ggctatggga     5040

ctgtcaggag agaaggggta tagagacagc atgaaatgga gcctgctgca ctttctttaa     5100

ggctctgctc ctcctgacag gactgggagg gcaacctgcg ctacgctgag tatagccact     5160

ttgttttggg caatgaactc aacagctatc gcctcttcct ggggaactac actggcaatg     5220

tggggaacga cgccctccag tatcataaca acacagcctt cagcaccaag gacaaggaca     5280

atgacaactg cttggacaag tgtgcacagc tccgcaaagg tgagatttgg ggggaccgga     5340

aaggagaagt tcaggtacaa gctcataatc ccacttgagg agaaagagtg aattataact     5400

gtacagttga tattccggtt ttggtattct ttctgaccct ggctctaact ccttacctga     5460

tgtctggtct atcacagtca acttactagc actgggtctg tttctcatgc caggtggcta     5520

ctggtacaac tgctgcacag actccaacct caatggagtg tactaccgcc tgggtgagca     5580

caataagcac ctggatggca tcacctggta tggctggcat ggatctacct actccctcaa     5640

acgggtggag atgaaaatcc gcccagaaga cttcaagcct taaaaggagg ctgccgtgga     5700

gcacggatac agaaactgag acacgtggag actggatgag ggcagatgag gacaggaaga     5760

gagtgttaga aagggtagga ctgagaaaca gcctataatc tccaaagaaa gaataagtct     5820

ccaaggagca caaaaaaatc atatgtacca aggatgttac agtaaacagg atgaactatt     5880

taaacccact gggtcctgcc acatccttct caaggtggta gactgagtgg ggtctctctg     5940

cccaagatcc ctgacatagc agtagcttgt cttttccaca tgatttgtct gtgaaagaaa     6000

ataattttga gatcgtttta tctattttct ctacggctta ggctatgtga gggcaaaaca     6060

caaatccctt tgctaaaaag aaccatatta ttttgattct caaaggatag gcctttgagt     6120

gttagagaaa ggagtgaagg aggcaggtgg gaaatggtat ttctattttt aaatccagtg     6180

aaattatctt gagtctacac attattttta aaacacaaaa attgttcggc tggaactgac     6240

ccaggctgga cttgcgggga ggaaactcca gggcactgca tctggcgatc agactctgag     6300

cactgcccct gctcgccttg gtcatgtaca gcactgaaag gaatgaagca ccagcaggag     6360

gtggacagag tctctcatgg atgccggcac aaaactgcct taaaatattc atagttaata     6420

caggtatatc tatttttatt tactttgtaa gaaacaagct caaggagctt ccttttaaat     6480

tttgtctgta ggaaatggtt gaaaactgaa ggtagatggt gttatagtta ataataaatg     6540

ctgtaaataa gcatctcact ttgtaaaaat aaaatattgt ggttttgttt taaacattca     6600

acgtttcttt tccttctaca ataaacactt tcaaaatgtg a                         6641


<210>  135
<211>  1041
<212>  DNA
<213>  homo sapien

<400>  135
augcugaaaa agccucucuc agcugugacc uggcucugca uuuucaucgu ggccuuuguc       60

agccacccag cguggcugca gaagcucucu aagcacaaga caccagcaca gccacagcuc      120

aaagcggcca acugcuguga ggaggugaag gagcucaagg cccaaguugc caaccuuagc      180

agccugcuga gugaacugaa caagaagcag gagagggacu gggucagcgu ggucaugcag      240

gugauggagc uggagagcaa cagcaagcgc auggagucgc ggcucacaga ugcugagagc      300

aaguacuccg agaugaacaa ccaaauugac aucaugcagc ugcaggcagc acagacgguc      360

acucagaccu ccgcagaugc caucuacgac ugcucuuccc ucuaccagaa gaacuaccgc      420

aucucuggag uguauaagcu uccuccugau gacuuccugg gcagcccuga acuggaggug      480

aucugugaca uggagacuuc aggcggaggc uggaccauca uccagagacg aaaaaguggc      540

cuugucuccu ucuaccggga cuggaagcag uacaagcagg gcuuuggcag cauccguggg      600

gacuucuggc uggggaacga acacauccac cggcucucca gacagccaac ccggcugcgu      660

guagagaugg aggacuggga gggcaaccug cgcuacgcug aguauagcca cuuuguuuug      720

ggcaaugaac ucaacagcua ucgccucuuc cuggggaacu acacuggcaa uguggggaac      780

gacgcccucc aguaucauaa caacacagcc uucagcacca aggacaagga caaugacaac      840

ugcuuggaca agugugcaca gcuccgcaaa gguggcuacu gguacaacug cugcacagac      900

uccaaccuca auggagugua cuaccgccug ggugagcaca auaagcaccu ggauggcauc      960

accugguaug gcuggcaugg aucuaccuac ucccucaaac ggguggagau gaaaauccgc     1020

ccagaagacu ucaagccuua a                                               1041


<210>  136
<211>  1041
<212>  DNA
<213>  homo sapien

<400>  136
augcugaaaa agccucucuc agcugugacc uggcucugca uuuucaucgu ggccuuuguc       60

agccacccag cguggcugca gaagcucucu aagcacaaga caccagcaca gccacagcuc      120

aaagcggcca acugcuguga ggaggugaag gagcucaagg cccaaguugc caaccuuagc      180

agccugcuga gugaacugaa caagaagcag gagagggacu gggucagcgu ggucaugcag      240

gugauggagc uggagagcaa cagcaagcgc auggagucgc ggcucacaga ugcugagagc      300

aaguacuccg agaugaacaa ccaaauugac aucaugcagc ugcaggcagc acagacgguc      360

acucagaccu ccgcagaugc caucuacgac ugcucuuccc ucuaccagaa gaacuaccgc      420

aucucuggag uguauaagcu uccuccugau gacuuccugg gcagcccuga acuggaggug      480

uucugugaca uggagacuuc aggcggaggc uggaccauca uccagagacg aaaaaguggc      540

cuugucuccu ucuaccggga cuagaagcag uacaagcagg gcuuuggcag cauccguggg      600

gacuucuggc uggggaacga acacauccac cggcucucca gacagccaac ccggcugcgu      660

guagagaugg aggacuggga gggcaaccug cgcuacgcug aguauagcca cuuuguuuug      720

ggcaaugaac ucaacagcua ucgccucuuc cuggggaacu acacuggcaa uguggggaac      780

gacgcccucc aguaucauaa caacacagcc uucagcacca aggacaagga caaugacaac      840

ugcuuggaca agugugcaca gcuccgcaaa gguggcuacu gguacaacug cugcacagac      900

uccaaccuca auggagugua cuaccgccug ggugagcaca auaagcaccu ggauggcauc      960

accugguaug gcuggcaugg aucuaccuac ucccucaaac ggguggagau gaaaauccgc     1020

ccagaagacu ucaagccuua a                                               1041


<210>  137
<211>  1041
<212>  DNA
<213>  homo sapien

<400>  137
augcugaaaa agccucucuc agcugugacc uggcucugca uuuucaucgu ggccuuuguc       60

agccacccag cguggcugca gaagcucucu aagcacaaga caccagcaca gccacagcuc      120

aaagcggcca acugcuguga ggaggugaag gagcucaagg cccaaguugc caaccuuagc      180

agccugcuga gugaacugaa caagaagcag gagagggacu gggucagcgu ggucaugcag      240

gugauggagc uggagagcaa cagcaagcgc auggagucgc ggcucacaga ugcugagagc      300

aaguacuccg agaugaacaa ccaaauugac aucaugcagc ugcaggcagc acagacgguc      360

acucagaccu ccgcagaugc caucuacgac ugcucuuccc ucuaccagaa gaacuaccgc      420

aucucuggag uguauaagcu uccuccugau gacuuccugg gcagcccuga acuggaggug      480

uucugugaca uggagacuuc aggcggaggc uggaccauca uccagagacg aaaaaguggc      540

cuugucuccu ucuaccggga cuggaagcag uaccagcagg gcuuuggcag cauccguggg      600

gacuucuggc uggggaacga acacauccac cggcucucca gacagccaac ccggcugcgu      660

guagagaugg aggacuggga gggcaaccug cgcuacgcug aguauagcca cuuuguuuug      720

ggcaaugaac ucaacagcua ucgccucuuc cuggggaacu acacuggcaa uguggggaac      780

gacgcccucc aguaucauaa caacacagcc uucagcacca aggacaagga caaugacaac      840

ugcuuggaca agugugcaca gcuccgcaaa gguggcuacu gguacaacug cugcacagac      900

uccaaccuca auggagugua cuaccgccug ggugagcaca auaagcaccu ggauggcauc      960

accugguaug gcuggcaugg aucuaccuac ucccucaaac ggguggagau gaaaauccgc     1020

ccagaagacu ucaagccuua a                                               1041


<210>  138
<211>  1041
<212>  DNA
<213>  homo sapien

<400>  138
atgctgaaaa agcctctctc agctgtgacc tggctctgca ttttcatcgt ggcctttgtc       60

agccacccag cgtggctgca gaagctctct aagcacaaga caccagcaca gccacagctc      120

aaagcggcca actgctgtga ggaggtgaag gagctcaagg cccaagttgc caaccttagc      180

agcctgctga gtgaactgaa caagaagcag gagagggact gggtcagcgt ggtcatgcag      240

gtgatggagc tggagagcaa cagcaagcgc atggagtcgc ggctcacaga tgctgagagc      300

aagtactccg agatgaacaa ccaaattgac atcatgcagc tgcaggcagc acagacggtc      360

actcagacct ccgcagatgc catctacgac tgctcttccc tctaccagaa gaactaccgc      420

atctctggag tgtataagct tcctcctgat gacttcctgg gcagccctga actggaggtg      480

atctgtgaca tggagacttc aggcggaggc tggaccatca tccagagacg aaaaagtggc      540

cttgtctcct tctaccggga ctggaagcag tacaagcagg gctttggcag catccgtggg      600

gacttctggc tggggaacga acacatccac cggctctcca gacagccaac ccggctgcgt      660

gtagagatgg aggactggga gggcaacctg cgctacgctg agtatagcca ctttgttttg      720

ggcaatgaac tcaacagcta tcgcctcttc ctggggaact acactggcaa tgtggggaac      780

gacgccctcc agtatcataa caacacagcc ttcagcacca aggacaagga caatgacaac      840

tgcttggaca agtgtgcaca gctccgcaaa ggtggctact ggtacaactg ctgcacagac      900

tccaacctca atggagtgta ctaccgcctg ggtgagcaca ataagcacct ggatggcatc      960

acctggtatg gctggcatgg atctacctac tccctcaaac gggtggagat gaaaatccgc     1020

ccagaagact tcaagcctta a                                               1041


<210>  139
<211>  1041
<212>  DNA
<213>  homo sapien

<400>  139
atgctgaaaa agcctctctc agctgtgacc tggctctgca ttttcatcgt ggcctttgtc       60

agccacccag cgtggctgca gaagctctct aagcacaaga caccagcaca gccacagctc      120

aaagcggcca actgctgtga ggaggtgaag gagctcaagg cccaagttgc caaccttagc      180

agcctgctga gtgaactgaa caagaagcag gagagggact gggtcagcgt ggtcatgcag      240

gtgatggagc tggagagcaa cagcaagcgc atggagtcgc ggctcacaga tgctgagagc      300

aagtactccg agatgaacaa ccaaattgac atcatgcagc tgcaggcagc acagacggtc      360

actcagacct ccgcagatgc catctacgac tgctcttccc tctaccagaa gaactaccgc      420

atctctggag tgtataagct tcctcctgat gacttcctgg gcagccctga actggaggtg      480

ttctgtgaca tggagacttc aggcggaggc tggaccatca tccagagacg aaaaagtggc      540

cttgtctcct tctaccggga ctagaagcag tacaagcagg gctttggcag catccgtggg      600

gacttctggc tggggaacga acacatccac cggctctcca gacagccaac ccggctgcgt      660

gtagagatgg aggactggga gggcaacctg cgctacgctg agtatagcca ctttgttttg      720

ggcaatgaac tcaacagcta tcgcctcttc ctggggaact acactggcaa tgtggggaac      780

gacgccctcc agtatcataa caacacagcc ttcagcacca aggacaagga caatgacaac      840

tgcttggaca agtgtgcaca gctccgcaaa ggtggctact ggtacaactg ctgcacagac      900

tccaacctca atggagtgta ctaccgcctg ggtgagcaca ataagcacct ggatggcatc      960

acctggtatg gctggcatgg atctacctac tccctcaaac gggtggagat gaaaatccgc     1020

ccagaagact tcaagcctta a                                               1041


<210>  140
<211>  1041
<212>  DNA
<213>  homo sapien

<400>  140
atgctgaaaa agcctctctc agctgtgacc tggctctgca ttttcatcgt ggcctttgtc       60

agccacccag cgtggctgca gaagctctct aagcacaaga caccagcaca gccacagctc      120

aaagcggcca actgctgtga ggaggtgaag gagctcaagg cccaagttgc caaccttagc      180

agcctgctga gtgaactgaa caagaagcag gagagggact gggtcagcgt ggtcatgcag      240

gtgatggagc tggagagcaa cagcaagcgc atggagtcgc ggctcacaga tgctgagagc      300

aagtactccg agatgaacaa ccaaattgac atcatgcagc tgcaggcagc acagacggtc      360

actcagacct ccgcagatgc catctacgac tgctcttccc tctaccagaa gaactaccgc      420

atctctggag tgtataagct tcctcctgat gacttcctgg gcagccctga actggaggtg      480

ttctgtgaca tggagacttc aggcggaggc tggaccatca tccagagacg aaaaagtggc      540

cttgtctcct tctaccggga ctggaagcag taccagcagg gctttggcag catccgtggg      600

gacttctggc tggggaacga acacatccac cggctctcca gacagccaac ccggctgcgt      660

gtagagatgg aggactggga gggcaacctg cgctacgctg agtatagcca ctttgttttg      720

ggcaatgaac tcaacagcta tcgcctcttc ctggggaact acactggcaa tgtggggaac      780

gacgccctcc agtatcataa caacacagcc ttcagcacca aggacaagga caatgacaac      840

tgcttggaca agtgtgcaca gctccgcaaa ggtggctact ggtacaactg ctgcacagac      900

tccaacctca atggagtgta ctaccgcctg ggtgagcaca ataagcacct ggatggcatc      960

acctggtatg gctggcatgg atctacctac tccctcaaac gggtggagat gaaaatccgc     1020

ccagaagact tcaagcctta a                                               1041


<210>  141
<211>  346
<212>  PRT
<213>  homo sapien

<400>  141

Met Leu Lys Lys Pro Leu Ser Ala Val Thr Trp Leu Cys Ile Phe Ile 
1               5                   10                  15      


Val Ala Phe Val Ser His Pro Ala Trp Leu Gln Lys Leu Ser Lys His 
            20                  25                  30          


Lys Thr Pro Ala Gln Pro Gln Leu Lys Ala Ala Asn Cys Cys Glu Glu 
        35                  40                  45              


Val Lys Glu Leu Lys Ala Gln Val Ala Asn Leu Ser Ser Leu Leu Ser 
    50                  55                  60                  


Glu Leu Asn Lys Lys Gln Glu Arg Asp Trp Val Ser Val Val Met Gln 
65                  70                  75                  80  


Val Met Glu Leu Glu Ser Asn Ser Lys Arg Met Glu Ser Arg Leu Thr 
                85                  90                  95      


Asp Ala Glu Ser Lys Tyr Ser Glu Met Asn Asn Gln Ile Asp Ile Met 
            100                 105                 110         


Gln Leu Gln Ala Ala Gln Thr Val Thr Gln Thr Ser Ala Asp Ala Ile 
        115                 120                 125             


Tyr Asp Cys Ser Ser Leu Tyr Gln Lys Asn Tyr Arg Ile Ser Gly Val 
    130                 135                 140                 


Tyr Lys Leu Pro Pro Asp Asp Phe Leu Gly Ser Pro Glu Leu Glu Val 
145                 150                 155                 160 


Ile Cys Asp Met Glu Thr Ser Gly Gly Gly Trp Thr Ile Ile Gln Arg 
                165                 170                 175     


Arg Lys Ser Gly Leu Val Ser Phe Tyr Arg Asp Trp Lys Gln Tyr Lys 
            180                 185                 190         


Gln Gly Phe Gly Ser Ile Arg Gly Asp Phe Trp Leu Gly Asn Glu His 
        195                 200                 205             


Ile His Arg Leu Ser Arg Gln Pro Thr Arg Leu Arg Val Glu Met Glu 
    210                 215                 220                 


Asp Trp Glu Gly Asn Leu Arg Tyr Ala Glu Tyr Ser His Phe Val Leu 
225                 230                 235                 240 


Gly Asn Glu Leu Asn Ser Tyr Arg Leu Phe Leu Gly Asn Tyr Thr Gly 
                245                 250                 255     


Asn Val Gly Asn Asp Ala Leu Gln Tyr His Asn Asn Thr Ala Phe Ser 
            260                 265                 270         


Thr Lys Asp Lys Asp Asn Asp Asn Cys Leu Asp Lys Cys Ala Gln Leu 
        275                 280                 285             


Arg Lys Gly Gly Tyr Trp Tyr Asn Cys Cys Thr Asp Ser Asn Leu Asn 
    290                 295                 300                 


Gly Val Tyr Tyr Arg Leu Gly Glu His Asn Lys His Leu Asp Gly Ile 
305                 310                 315                 320 


Thr Trp Tyr Gly Trp His Gly Ser Thr Tyr Ser Leu Lys Arg Val Glu 
                325                 330                 335     


Met Lys Ile Arg Pro Glu Asp Phe Lys Pro 
            340                 345     


<210>  142
<211>  187
<212>  PRT
<213>  homo sapien

<400>  142

Met Leu Lys Lys Pro Leu Ser Ala Val Thr Trp Leu Cys Ile Phe Ile 
1               5                   10                  15      


Val Ala Phe Val Ser His Pro Ala Trp Leu Gln Lys Leu Ser Lys His 
            20                  25                  30          


Lys Thr Pro Ala Gln Pro Gln Leu Lys Ala Ala Asn Cys Cys Glu Glu 
        35                  40                  45              


Val Lys Glu Leu Lys Ala Gln Val Ala Asn Leu Ser Ser Leu Leu Ser 
    50                  55                  60                  


Glu Leu Asn Lys Lys Gln Glu Arg Asp Trp Val Ser Val Val Met Gln 
65                  70                  75                  80  


Val Met Glu Leu Glu Ser Asn Ser Lys Arg Met Glu Ser Arg Leu Thr 
                85                  90                  95      


Asp Ala Glu Ser Lys Tyr Ser Glu Met Asn Asn Gln Ile Asp Ile Met 
            100                 105                 110         


Gln Leu Gln Ala Ala Gln Thr Val Thr Gln Thr Ser Ala Asp Ala Ile 
        115                 120                 125             


Tyr Asp Cys Ser Ser Leu Tyr Gln Lys Asn Tyr Arg Ile Ser Gly Val 
    130                 135                 140                 


Tyr Lys Leu Pro Pro Asp Asp Phe Leu Gly Ser Pro Glu Leu Glu Val 
145                 150                 155                 160 


Phe Cys Asp Met Glu Thr Ser Gly Gly Gly Trp Thr Ile Ile Gln Arg 
                165                 170                 175     


Arg Lys Ser Gly Leu Val Ser Phe Tyr Arg Asp 
            180                 185         


<210>  143
<211>  346
<212>  PRT
<213>  homo sapien

<400>  143

Met Leu Lys Lys Pro Leu Ser Ala Val Thr Trp Leu Cys Ile Phe Ile 
1               5                   10                  15      


Val Ala Phe Val Ser His Pro Ala Trp Leu Gln Lys Leu Ser Lys His 
            20                  25                  30          


Lys Thr Pro Ala Gln Pro Gln Leu Lys Ala Ala Asn Cys Cys Glu Glu 
        35                  40                  45              


Val Lys Glu Leu Lys Ala Gln Val Ala Asn Leu Ser Ser Leu Leu Ser 
    50                  55                  60                  


Glu Leu Asn Lys Lys Gln Glu Arg Asp Trp Val Ser Val Val Met Gln 
65                  70                  75                  80  


Val Met Glu Leu Glu Ser Asn Ser Lys Arg Met Glu Ser Arg Leu Thr 
                85                  90                  95      


Asp Ala Glu Ser Lys Tyr Ser Glu Met Asn Asn Gln Ile Asp Ile Met 
            100                 105                 110         


Gln Leu Gln Ala Ala Gln Thr Val Thr Gln Thr Ser Ala Asp Ala Ile 
        115                 120                 125             


Tyr Asp Cys Ser Ser Leu Tyr Gln Lys Asn Tyr Arg Ile Ser Gly Val 
    130                 135                 140                 


Tyr Lys Leu Pro Pro Asp Asp Phe Leu Gly Ser Pro Glu Leu Glu Val 
145                 150                 155                 160 


Phe Cys Asp Met Glu Thr Ser Gly Gly Gly Trp Thr Ile Ile Gln Arg 
                165                 170                 175     


Arg Lys Ser Gly Leu Val Ser Phe Tyr Arg Asp Trp Lys Gln Tyr Gln 
            180                 185                 190         


Gln Gly Phe Gly Ser Ile Arg Gly Asp Phe Trp Leu Gly Asn Glu His 
        195                 200                 205             


Ile His Arg Leu Ser Arg Gln Pro Thr Arg Leu Arg Val Glu Met Glu 
    210                 215                 220                 


Asp Trp Glu Gly Asn Leu Arg Tyr Ala Glu Tyr Ser His Phe Val Leu 
225                 230                 235                 240 


Gly Asn Glu Leu Asn Ser Tyr Arg Leu Phe Leu Gly Asn Tyr Thr Gly 
                245                 250                 255     


Asn Val Gly Asn Asp Ala Leu Gln Tyr His Asn Asn Thr Ala Phe Ser 
            260                 265                 270         


Thr Lys Asp Lys Asp Asn Asp Asn Cys Leu Asp Lys Cys Ala Gln Leu 
        275                 280                 285             


Arg Lys Gly Gly Tyr Trp Tyr Asn Cys Cys Thr Asp Ser Asn Leu Asn 
    290                 295                 300                 


Gly Val Tyr Tyr Arg Leu Gly Glu His Asn Lys His Leu Asp Gly Ile 
305                 310                 315                 320 


Thr Trp Tyr Gly Trp His Gly Ser Thr Tyr Ser Leu Lys Arg Val Glu 
                325                 330                 335     


Met Lys Ile Arg Pro Glu Asp Phe Lys Pro 
            340                 345     


<210>  144
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  144
acagaacacc tgaagcagag ggg                                               23


<210>  145
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  145
acagaacacc tgaagcagag ggg                                               23


<210>  146
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  146
cacagaacac ctgaagcaga ggg                                               23


<210>  147
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  147
cagagtatcc cctctgcttc agg                                               23


<210>  148
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  148
actctggtga gggacttgca ggg                                               23


<210>  149
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  149
tactctggtg agggacttgc agg                                               23


<210>  150
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  150
gcagagggga tactctggtg agg                                               23


<210>  151
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  151
gcttcaggtg ttctgtgaca tgg                                               23


<210>  152
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  152
cagaggggat actctggtga ggg                                               23


<210>  153
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  153
ttgtctcctt ctaccgggac tgg                                               23


<210>  154
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  154
gtggccttgt ctccttctac cgg                                               23


<210>  155
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  155
tggccttgtc tccttctacc ggg                                               23


<210>  156
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  156
gactggaagc agtacaagca ggg                                               23


<210>  157
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  157
ggactggaag cagtacaagc agg                                               23


<210>  158
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  158
ctgcttccag tcccggtaga agg                                               23


<210>  159
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  159
gcttgtactg cttccagtcc cgg                                               23


<210>  160
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  160
agtcccggta gaaggagaca agg                                               23


<210>  161
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  161
aagcagtaca agcagggctt tgg                                               23


<210>  162
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  162
cagggctttg gcagcatccg tgg                                               23


<210>  163
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  163
agggctttgg cagcatccgt ggg                                               23


<210>  164
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  164
gggctttggc agcatccgtg ggg                                               23


<210>  165
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  Guide RNA Recognition Sequence

<400>  165
tccccagcca gaagtcccca cgg                                               23


