<110>    Curebio. Co., Ltd.

<120>    Novel polypeptides with skin whitening activity and use thereof

<130>    OP19-0211/PCT

<150>    KR 10-2019-0010176
<151>    2019-01-25

<160>    10

<170>    KoPatentIn 3.0

<210>    1
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of peptide for skin whitening(AIMP1 18aa -
         32aa)


<400>    1
Ala Asp Gln Ile Ile Glu Tyr Leu Lys Gln Gln Val Ser Leu Leu
  1               5                  10                  15


<210>    2
<211>    45
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleic acid sequence of peptide for skin whitening(AIMP1 18aa -
         32aa)


<400>    2
gcagatcaaa tcattgaata tcttaagcag caagtttctc tactt                         45


<210>    3
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of peptide for skin whitening(AIMP1 17aa -
         31aa)


<400>    3
Glu Ala Asp Gln Ile Ile Glu Tyr Leu Lys Gln Gln Val Ser Leu
  1               5                  10                  15


<210>    4
<211>    45
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleic acid sequence of peptide for skin whitening(AIMP1 17aa -
         31aa)


<400>    4
gaggcagatc aaatcattga atatcttaag cagcaagttt ctcta                         45


<210>    5
<211>    20
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of peptide for skin whitening(AIMP1 16aa -
         35aa)


<400>    5
Ala Glu Ala Asp Gln Ile Ile Glu Tyr Leu Lys Gln Gln Val Ser Leu
  1               5                  10                  15 

Leu Lys Glu Lys
             20


<210>    6
<211>    60
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleic acid sequence of peptide for skin whitening(AIMP1 16aa -
         35aa)


<400>    6
gcagaggcag atcaaatcat tgaatatctt aagcagcaag tttctctact taaggagaaa         60

                                                                          60


<210>    7
<211>    20
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of peptide for skin whitening(AIMP1 14aa -
         33aa)


<400>    7
Lys Gly Ala Glu Ala Asp Gln Ile Ile Glu Tyr Leu Lys Gln Gln Val
  1               5                  10                  15 

Ser Leu Leu Lys
             20


<210>    8
<211>    60
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    nucleic acid sequence of peptide for skin whitening(AIMP1 14aa -
         33aa)


<400>    8
aagggtgcag aggcagatca aatcattgaa tatcttaagc agcaagtttc tctacttaag         60

                                                                          60


<210>    9
<211>    312
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    amino acid sequence of AIMP1 protein(full length_homo sapiens)


<400>    9
Met Ala Asn Asn Asp Ala Val Leu Lys Arg Leu Glu Gln Lys Gly Ala
  1               5                  10                  15 

Glu Ala Asp Gln Ile Ile Glu Tyr Leu Lys Gln Gln Val Ser Leu Leu
             20                  25                  30 

Lys Glu Lys Ala Ile Leu Gln Ala Thr Leu Arg Glu Glu Lys Lys Leu
         35                  40                  45 

Arg Val Glu Asn Ala Lys Leu Lys Lys Glu Ile Glu Glu Leu Lys Gln
     50                  55                  60 

Glu Leu Ile Gln Ala Glu Ile Gln Asn Gly Val Lys Gln Ile Pro Phe
 65                  70                  75                  80 

Pro Ser Gly Thr Pro Leu His Ala Asn Ser Met Val Ser Glu Asn Val
                 85                  90                  95 

Ile Gln Ser Thr Ala Val Thr Thr Val Ser Ser Gly Thr Lys Glu Gln
            100                 105                 110 

Ile Lys Gly Gly Thr Gly Asp Glu Lys Lys Ala Lys Glu Lys Ile Glu
        115                 120                 125 

Lys Lys Gly Glu Lys Lys Glu Lys Lys Gln Gln Ser Ile Ala Gly Ser
    130                 135                 140 

Ala Asp Ser Lys Pro Ile Asp Val Ser Arg Leu Asp Leu Arg Ile Gly
145                 150                 155                 160 

Cys Ile Ile Thr Ala Arg Lys His Pro Asp Ala Asp Ser Leu Tyr Val
                165                 170                 175 

Glu Glu Val Asp Val Gly Glu Ile Ala Pro Arg Thr Val Val Ser Gly
            180                 185                 190 

Leu Val Asn His Val Pro Leu Glu Gln Met Gln Asn Arg Met Val Ile
        195                 200                 205 

Leu Leu Cys Asn Leu Lys Pro Ala Lys Met Arg Gly Val Leu Ser Gln
    210                 215                 220 

Ala Met Val Met Cys Ala Ser Ser Pro Glu Lys Ile Glu Ile Leu Ala
225                 230                 235                 240 

Pro Pro Asn Gly Ser Val Pro Gly Asp Arg Ile Thr Phe Asp Ala Phe
                245                 250                 255 

Pro Gly Glu Pro Asp Lys Glu Leu Asn Pro Lys Lys Lys Ile Trp Glu
            260                 265                 270 

Gln Ile Gln Pro Asp Leu His Thr Asn Asp Glu Cys Val Ala Thr Tyr
        275                 280                 285 

Lys Gly Val Pro Phe Glu Val Lys Gly Lys Gly Val Cys Arg Ala Gln
    290                 295                 300 

Thr Met Ser Asn Ser Gly Ile Lys
305                 310        


<210>    10
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    peptide fragment from AIMP1(AIMP1 32aa - 46aa)


<400>    10
Leu Lys Glu Lys Ala Ile Leu Gln Ala Thr Leu Arg Glu Glu Lys
  1               5                  10                  15
