                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       HANNA, Yaqub
       NOVERSHTERN, Noa
       SHANI, Tom
       VIUKOV, Sergey
       MASSARWA, Rada
       BAYERL, Jonathan
       AYYASH, Muneef
 
<120>  CULTURE MEDIA FOR PLURIPOTENT STEM CELLS

<130>  80467

<150>  US 62/795,626
<151>  2019-01-23

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  1
ggggcccgcc tgctctttct gggtgatccc cgac                                   34


<210>  2
<211>  14
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  2
ccggacgaga aaga                                                         14


<210>  3
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  3
ccggaacgag aaaga                                                        15


<210>  4
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  4
cgttgtaagc aaagagtgcg                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  5
ctaccacaaa tgtcccacgc                                                   20


<210>  6
<211>  59
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  6
cctgggtctt cagtgaacca ttgttcaata tcgtccgggg acagcatcaa atcatccat        59


<210>  7
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  7
atgctgtccc cggacgatat tgaacaatgg ttcactgaag                             40


<210>  8
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  8
atgctgtccc cgtgagccac cgtgcccact gaag                                   34


<210>  9
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  9
gtccccggac gatattgaa                                                    19


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  10
gtccccggaa cgatattgaa                                                   20


<210>  11
<211>  88
<212>  PRT
<213>  homo sapiens

<400>  11

Met Lys Val Leu Ala Ala Val His Ser Pro Gly Gly Ala Val Pro Gln 
1               5                   10                  15      


Gln Pro Gly Gln Ala Met Trp Pro Gln Arg Asp Gly Leu Pro Ala Leu 
            20                  25                  30          


Pro Arg Gln Arg His Gly Glu Gly Gln Ala Gly Gly Ala Val Pro His 
        35                  40                  45              


Ser Arg Val Pro Trp His Leu Pro Gly Gln His His Pro Gly Pro Glu 
    50                  55                  60                  


Asp Pro Gln Pro Gln Cys Pro Gln Pro Pro Gln Gln Ala Gln Arg His 
65                  70                  75                  80  


Arg Arg His Pro Ala Arg Pro Pro 
                85              


<210>  12
<211>  3808
<212>  DNA
<213>  homo sapiens

<400>  12
cttcctggac tggggatccc ggctaaatat agctgtttct gtcttacaac acaggctcca       60

gtatataaat caggcaaatt ccccatttga gcatgaacct ctgaaaactg ccggcatctg      120

aggtttcctc caaggccctc tgaagtgcag cccataatga aggtcttggc ggcagtacac      180

agcccagggg gagccgttcc ccaacaacct ggacaagcta tgtggcccca acgtgacgga      240

cttcccgccc ttccacgcca acggcacgga gaaggccaag ctggtggagc tgtaccgcat      300

agtcgtgtac cttggcacct ccctgggcaa catcacccgg gaccagaaga tcctcaaccc      360

cagtgccctc agcctccaca gcaagctcaa cgccaccgcc gacatcctgc gaggcctcct      420

tagcaacgtg ctgtgccgcc tgtgcagcaa gtaccacgtg ggccatgtgg acgtgaccta      480

cggccctgac acctcgggta aggatgtctt ccagaagaag aagctgggct gtcaactcct      540

ggggaagtat aagcagatca tcgccgtgtt ggcccaggcc ttctagcagg aggtcttgaa      600

gtgtgctgtg aaccgaggga tctcaggagt tgggtccaga tgtgggggcc tgtccaaggg      660

tggctggggc ccagggcatc gctaaaccca aatgggggct gctggcagac cccgagggtg      720

cctggccagt ccactccact ctgggctggg ctgtgatgaa gctgagcaga gtggaaactt      780

ccatagggag ggagctagaa gaaggtgccc cttcctctgg gagattgtgg actggggagc      840

gtgggctgga cttctgcctc tacttgtccc tttggcccct tgctcacttt gtgcagtgaa      900

caaactacac aagtcatcta caagagccct gaccacaggg tgagacagca gggcccaggg      960

gagtggacca gcccccagca aattatcacc atctgtgcct ttgctgcccc ttaggttggg     1020

acttaggtgg gccagagggg ctaggatccc aaaggactcc ttgtccccta gaagtttgat     1080

gagtggaaga tagagagggg cctctgggat ggaaggctgt cttcttttga ggatgatcag     1140

agaacttggg cataggaaca atctggcaga agtttccaga aggaggtcac ttggcattca     1200

ggctcttggg gaggcagaga agccaccttc aggcctggga aggaagacac tgggaggagg     1260

agaggcctgg aaagctttgg taggttcttc gttctcttcc ccgtgatctt ccctgcagcc     1320

tgggatggcc agggtctgat ggctggacct gcagcagggg tttgtggagg tgggtagggc     1380

aggggcaggt tgctaagtca ggtgcagagg ttctgaggga cccaggctct tcctctgggt     1440

aaaggtctgt aagaaggggc tggggtagct cagagtagca gctcacatct gaggccctgg     1500

gaggccttgt gaggtcacac agaggtactt gagggggact ggaggccgtc tctggtcccc     1560

agggcaaggg aacagcagaa cttagggtca gggtctcagg gaaccctgag ctccaagcgt     1620

gctgtgcgtc tgacctggca tgatttctat ttattatgat atcctattta tattaactta     1680

ttggtgcttt cagtggccaa gttaattccc ctttccctgg tccctactca acaaaatatg     1740

atgatggctc ccgacacaag cgccagggcc agggcttagc agggcctggt ctggaagtcg     1800

acaatgttac aagtggaata agccttacgg gtgaagctca gagaagggtc ggatctgaga     1860

gaatggggag gcctgagtgg gagtgggggg ccttgctcca ccccccccca tcccctactg     1920

tgacttgctt tagggtgtca gggtccaggc tgcaggggct gggccaattt gtggagaggc     1980

cgggtgcctt tctgtcttga ttccaggggg ctggttcaca ctgttcttgg gcgccccagc     2040

attgtgttgt gaggcgcact gttcctggca gatattgtgc cccctggagc agtgggcaag     2100

acagtccttg tggcccaccc tgtccttgtt tctgtgtccc catgctgcct ctgaaatagc     2160

gccctggaac aaccctgccc ctgcacccag catgctccga cacagcaggg aagctcctcc     2220

tgtggcccgg acacccatag acggtgcggg gggcctggct gggccagacc ccaggaaggt     2280

ggggtagact ggggggatca gctgcccatt gctcccaaga ggaggagagg gaggctgcag     2340

atgcctggga ctcagaccag gaagctgtgg gccctcctgc tccaccccca tcccactccc     2400

acccatgtct gggctcccag gcagggaacc cgatctcttc ctttgtgctg gggccaggcg     2460

agtggagaaa cgccctccag tctgagagca ggggagggaa ggaggcagca gagttggggc     2520

agctgctcag agcagtgttc tggcttcttc tcaaaccctg agcgggctgc cggcctccaa     2580

gttcctccga caagatgatg gtactaatta tggtactttt cactcacttt gcacctttcc     2640

ctgtcgctct ctaagcactt tacctggatg gcgcgtgggc agtgtgcagg caggtcctga     2700

ggcctggggt tggggtggag ggtgcggccc ggagttgtcc atctgtccat cccaacagca     2760

agacgaggat gtggctgttg agatgtgggc cacactcacc cttgtccagg atgcagggac     2820

tgccttctcc ttcctgcttc atccggctta gcttggggct ggctgcattc ccccaggatg     2880

ggcttcgaga aagacaaact tgtctggaaa ccagagttgc tgattccacc cggggggccc     2940

ggctgactcg cccatcacct catctccctg tggacttggg agctctgtgc caggcccacc     3000

ttgcggccct ggctctgagt cgctctccca cccagcctgg acttggcccc atgggaccca     3060

tcctcagtgc tccctccaga tcccgtccgg cagcttggcg tccaccctgc acagcatcac     3120

tgaatcacag agcctttgcg tgaaacagct ctgccaggcc gggagctggg tttctcttcc     3180

ctttttatct gctggtgtgg accacacctg ggcctggccg gaggaagaga gagtttacca     3240

agagagatgt ctccgggccc ttatttatta tttaaacatt tttttaaaaa gcactgctag     3300

tttacttgtc tctcctcccc atcgtcccca tcgtcctcct tgtccctgac ttggggcact     3360

tccaccctga cccagccagt ccagctctgc cttgccggct ctccagagta gacatagtgt     3420

gtggggttgg agctctggca cccggggagg tagcatttcc ctgcagatgg tacagatgtt     3480

cctgccttag agtcatctct agttccccac ctcaatcccg gcatccagcc ttcagtcccg     3540

cccacgtgct agctccgtgg gcccaccgtg cggccttaga ggtttccctc cttcctttcc     3600

actgaaaagc acatggcctt gggtgacaaa ttcctctttg atgaatgtac cctgtgggga     3660

tgtttcatac tgacagatta tttttattta ttcaatgtca tatttaaaat atttattttt     3720

tataccaaat gaatactttt ttttttaaga aaaaaaagag aaatgaataa agaatctact     3780

cttggctggc aaaaaaaaaa aaaaaaaa                                        3808


<210>  13
<211>  212
<212>  PRT
<213>  homo sapiens

<400>  13

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  14
<211>  1201
<212>  DNA
<213>  homo sapiens

<400>  14
aatattagag tctcaacccc caataaatat aggactggag atgtctgagg ctcattctgc       60

cctcgagccc accgggaacg aaagagaagc tctatctccc ctccaggagc ccagctatga      120

actccttctc cacaagcgcc ttcggtccag ttgccttctc cctggggctg ctcctggtgt      180

tgcctgctgc cttccctgcc ccagtacccc caggagaaga ttccaaagat gtagccgccc      240

cacacagaca gccactcacc tcttcagaac gaattgacaa acaaattcgg tacatcctcg      300

acggcatctc agccctgaga aaggagacat gtaacaagag taacatgtgt gaaagcagca      360

aagaggcact ggcagaaaac aacctgaacc ttccaaagat ggctgaaaaa gatggatgct      420

tccaatctgg attcaatgag gagacttgcc tggtgaaaat catcactggt cttttggagt      480

ttgaggtata cctagagtac ctccagaaca gatttgagag tagtgaggaa caagccagag      540

ctgtgcagat gagtacaaaa gtcctgatcc agttcctgca gaaaaaggca aagaatctag      600

atgcaataac cacccctgac ccaaccacaa atgccagcct gctgacgaag ctgcaggcac      660

agaaccagtg gctgcaggac atgacaactc atctcattct gcgcagcttt aaggagttcc      720

tgcagtccag cctgagggct cttcggcaaa tgtagcatgg gcacctcaga ttgttgttgt      780

taatgggcat tccttcttct ggtcagaaac ctgtccactg ggcacagaac ttatgttgtt      840

ctctatggag aactaaaagt atgagcgtta ggacactatt ttaattattt ttaatttatt      900

aatatttaaa tatgtgaagc tgagttaatt tatgtaagtc atatttatat ttttaagaag      960

taccacttga aacattttat gtattagttt tgaaataata atggaaagtg gctatgcagt     1020

ttgaatatcc tttgtttcag agccagatca tttcttggaa agtgtaggct tacctcaaat     1080

aaatggctaa cttatacata tttttaaaga aatatttata ttgtatttat ataatgtata     1140

aatggttttt ataccaataa atggcatttt aaaaaattca gcaaaaaaaa aaaaaaaaaa     1200

a                                                                     1201


<210>  15
<211>  360
<212>  PRT
<213>  homo sapiens

<400>  15

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asn Gln Leu Gln Gln Ile Met Arg Leu Thr Gly 
225                 230                 235                 240 


Thr Pro Pro Ala Tyr Leu Ile Asn Arg Met Pro Ser His Glu Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
305                 310                 315                 320 


Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu 
                325                 330                 335     


Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
            340                 345                 350         


Leu Asp Gln Glu Glu Met Glu Ser 
        355                 360 


<210>  16
<211>  360
<212>  PRT
<213>  homo sapiens

<400>  16

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
225                 230                 235                 240 


Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
305                 310                 315                 320 


Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu 
                325                 330                 335     


Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
            340                 345                 350         


Leu Asp Gln Glu Glu Met Glu Ser 
        355                 360 


<210>  17
<211>  297
<212>  PRT
<213>  homo sapiens

<400>  17

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
225                 230                 235                 240 


Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Gly Lys Leu Thr Ile Tyr Pro His 
        275                 280                 285             


Leu Met Asp Ile Glu Leu Val Met Ile 
    290                 295         


<210>  18
<211>  307
<212>  PRT
<213>  homo sapiens

<400>  18

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
225                 230                 235                 240 


Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Leu Ser 
                245                 250                 255     


Thr Cys Trp Arg Arg Cys Leu Tyr Trp Thr Gln Ile Arg Glu Leu Gln 
            260                 265                 270         


Arg Pro Lys Pro Leu His Met Pro Thr Leu Leu Ser Thr Thr Ile Leu 
        275                 280                 285             


Met Met Asn Gln Trp Pro Ile Leu Met Ile Ser Pro Leu Lys Ala Gly 
    290                 295                 300                 


Thr Ser Leu 
305         


<210>  19
<211>  364
<212>  PRT
<213>  homo sapiens

<400>  19

Met Ser Gly Pro Arg Ala Gly Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Val Trp Glu Val Pro Gln Arg Leu Gln Gly Leu Arg Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ser Ala Tyr Asp Ala Arg Leu Arg Gln 
        35                  40                  45              


Lys Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Leu Ile His 
    50                  55                  60                  


Ala Arg Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Leu Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Thr Ser Ile 
                85                  90                  95      


Glu Asp Phe Ser Glu Val Tyr Leu Val Thr Thr Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Ala Leu Ser Asp Glu His Val Gln 
        115                 120                 125             


Phe Leu Val Tyr Gln Leu Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Val Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Arg Ile Leu Asp Phe Gly Leu Ala Arg Gln Ala Asp 
                165                 170                 175     


Glu Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Gln Gly Lys Ala Leu Phe Pro 
    210                 215                 220                 


Gly Ser Asp Tyr Ile Asp Gln Leu Lys Arg Ile Met Glu Val Val Gly 
225                 230                 235                 240 


Thr Pro Ser Pro Glu Val Leu Ala Lys Ile Ser Ser Glu His Ala Arg 
                245                 250                 255     


Thr Tyr Ile Gln Ser Leu Pro Pro Met Pro Gln Lys Asp Leu Ser Ser 
            260                 265                 270         


Ile Phe Arg Gly Ala Asn Pro Leu Ala Ile Asp Leu Leu Gly Arg Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Gln Arg Val Ser Ala Ala Glu Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ser Gln Tyr His Asp Pro Glu Asp Glu Pro Glu Ala 
305                 310                 315                 320 


Glu Pro Tyr Asp Glu Ser Val Glu Ala Lys Glu Arg Thr Leu Glu Glu 
                325                 330                 335     


Trp Lys Glu Leu Thr Tyr Gln Glu Val Leu Ser Phe Lys Pro Pro Glu 
            340                 345                 350         


Pro Pro Lys Pro Pro Gly Ser Leu Glu Ile Glu Gln 
        355                 360                 


<210>  20
<211>  367
<212>  PRT
<213>  homo sapiens

<400>  20

Met Ser Ser Pro Pro Pro Ala Arg Ser Gly Phe Tyr Arg Gln Glu Val 
1               5                   10                  15      


Thr Lys Thr Ala Trp Glu Val Arg Ala Val Tyr Arg Asp Leu Gln Pro 
            20                  25                  30          


Val Gly Ser Gly Ala Tyr Gly Ala Val Cys Ser Ala Val Asp Gly Arg 
        35                  40                  45              


Thr Gly Ala Lys Val Ala Ile Lys Lys Leu Tyr Arg Pro Phe Gln Ser 
    50                  55                  60                  


Glu Leu Phe Ala Lys Arg Ala Tyr Arg Glu Leu Arg Leu Leu Lys His 
65                  70                  75                  80  


Met Arg His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Asp 
                85                  90                  95      


Glu Thr Leu Asp Asp Phe Thr Asp Phe Tyr Leu Val Met Pro Phe Met 
            100                 105                 110         


Gly Thr Asp Leu Gly Lys Leu Met Lys His Glu Lys Leu Gly Glu Asp 
        115                 120                 125             


Arg Ile Gln Phe Leu Val Tyr Gln Met Leu Lys Gly Leu Arg Tyr Ile 
    130                 135                 140                 


His Ala Ala Gly Ile Ile His Arg Asp Leu Lys Pro Gly Asn Leu Ala 
145                 150                 155                 160 


Val Asn Glu Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg 
                165                 170                 175     


Gln Ala Asp Ser Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Asn Trp Met Arg Tyr Thr Gln Thr Val Asp 
        195                 200                 205             


Ile Trp Ser Val Gly Cys Ile Met Ala Glu Met Ile Thr Gly Lys Thr 
    210                 215                 220                 


Leu Phe Lys Gly Ser Asp His Leu Asp Gln Leu Lys Glu Ile Met Lys 
225                 230                 235                 240 


Val Thr Gly Thr Pro Pro Ala Glu Phe Val Gln Arg Leu Gln Ser Asp 
                245                 250                 255     


Glu Ala Lys Asn Tyr Met Lys Gly Leu Pro Glu Leu Glu Lys Lys Asp 
            260                 265                 270         


Phe Ala Ser Ile Leu Thr Asn Ala Ser Pro Leu Ala Val Asn Leu Leu 
        275                 280                 285             


Glu Lys Met Leu Val Leu Asp Ala Glu Gln Arg Val Thr Ala Gly Glu 
    290                 295                 300                 


Ala Leu Ala His Pro Tyr Phe Glu Ser Leu His Asp Thr Glu Asp Glu 
305                 310                 315                 320 


Pro Gln Val Gln Lys Tyr Asp Asp Ser Phe Asp Asp Val Asp Arg Thr 
                325                 330                 335     


Leu Asp Glu Trp Lys Arg Val Thr Tyr Lys Glu Val Leu Ser Phe Lys 
            340                 345                 350         


Pro Pro Arg Gln Leu Gly Ala Arg Val Ser Lys Glu Thr Pro Leu 
        355                 360                 365         


<210>  21
<211>  365
<212>  PRT
<213>  homo sapiens

<400>  21

Met Ser Leu Ile Arg Lys Lys Gly Phe Tyr Lys Gln Asp Val Asn Lys 
1               5                   10                  15      


Thr Ala Trp Glu Leu Pro Lys Thr Tyr Val Ser Pro Thr His Val Gly 
            20                  25                  30          


Ser Gly Ala Tyr Gly Ser Val Cys Ser Ala Ile Asp Lys Arg Ser Gly 
        35                  40                  45              


Glu Lys Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Ser Glu Ile 
    50                  55                  60                  


Phe Ala Lys Arg Ala Tyr Arg Glu Leu Leu Leu Leu Lys His Met Gln 
65                  70                  75                  80  


His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Ser Ser 
                85                  90                  95      


Leu Arg Asn Phe Tyr Asp Phe Tyr Leu Val Met Pro Phe Met Gln Thr 
            100                 105                 110         


Asp Leu Gln Lys Ile Met Gly Met Glu Phe Ser Glu Glu Lys Ile Gln 
        115                 120                 125             


Tyr Leu Val Tyr Gln Met Leu Lys Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Gly Val Val His Arg Asp Leu Lys Pro Gly Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Ala Asp 
                165                 170                 175     


Ala Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Val Ile Leu Ser Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Met Leu Thr Gly Lys Thr Leu Phe Lys 
    210                 215                 220                 


Gly Lys Asp Tyr Leu Asp Gln Leu Thr Gln Ile Leu Lys Val Thr Gly 
225                 230                 235                 240 


Val Pro Gly Thr Glu Phe Val Gln Lys Leu Asn Asp Lys Ala Ala Lys 
                245                 250                 255     


Ser Tyr Ile Gln Ser Leu Pro Gln Thr Pro Arg Lys Asp Phe Thr Gln 
            260                 265                 270         


Leu Phe Pro Arg Ala Ser Pro Gln Ala Ala Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Glu Leu Asp Val Asp Lys Arg Leu Thr Ala Ala Gln Ala Leu Thr 
    290                 295                 300                 


His Pro Phe Phe Glu Pro Phe Arg Asp Pro Glu Glu Glu Thr Glu Ala 
305                 310                 315                 320 


Gln Gln Pro Phe Asp Asp Ser Leu Glu His Glu Lys Leu Thr Val Asp 
                325                 330                 335     


Glu Trp Lys Gln His Ile Tyr Lys Glu Ile Val Asn Phe Ser Pro Ile 
            340                 345                 350         


Ala Arg Lys Asp Ser Arg Arg Arg Ser Gly Met Lys Leu 
        355                 360                 365 


<210>  22
<211>  232
<212>  PRT
<213>  homo sapiens

<400>  22

Met Glu Arg Cys Pro Ser Leu Gly Val Thr Leu Tyr Ala Leu Val Val 
1               5                   10                  15      


Val Leu Gly Leu Arg Ala Thr Pro Ala Gly Gly Gln His Tyr Leu His 
            20                  25                  30          


Ile Arg Pro Ala Pro Ser Asp Asn Leu Pro Leu Val Asp Leu Ile Glu 
        35                  40                  45              


His Pro Asp Pro Ile Phe Asp Pro Lys Glu Lys Asp Leu Asn Glu Thr 
    50                  55                  60                  


Leu Leu Arg Ser Leu Leu Gly Gly His Tyr Asp Pro Gly Phe Met Ala 
65                  70                  75                  80  


Thr Ser Pro Pro Glu Asp Arg Pro Gly Gly Gly Gly Gly Ala Ala Gly 
                85                  90                  95      


Gly Ala Glu Asp Leu Ala Glu Leu Asp Gln Leu Leu Arg Gln Arg Pro 
            100                 105                 110         


Ser Gly Ala Met Pro Ser Glu Ile Lys Gly Leu Glu Phe Ser Glu Gly 
        115                 120                 125             


Leu Ala Gln Gly Lys Lys Gln Arg Leu Ser Lys Lys Leu Arg Arg Lys 
    130                 135                 140                 


Leu Gln Met Trp Leu Trp Ser Gln Thr Phe Cys Pro Val Leu Tyr Ala 
145                 150                 155                 160 


Trp Asn Asp Leu Gly Ser Arg Phe Trp Pro Arg Tyr Val Lys Val Gly 
                165                 170                 175     


Ser Cys Phe Ser Lys Arg Ser Cys Ser Val Pro Glu Gly Met Val Cys 
            180                 185                 190         


Lys Pro Ser Lys Ser Val His Leu Thr Val Leu Arg Trp Arg Cys Gln 
        195                 200                 205             


Arg Arg Gly Gly Gln Arg Cys Gly Trp Ile Pro Ile Gln Tyr Pro Ile 
    210                 215                 220                 


Ile Ser Glu Cys Lys Cys Ser Cys 
225                 230         


<210>  23
<211>  1354
<212>  PRT
<213>  homo sapiens

<400>  23

Met Ser Thr Gly Asp Ser Phe Glu Thr Arg Phe Glu Lys Met Asp Asn 
1               5                   10                  15      


Leu Leu Arg Asp Pro Lys Ser Glu Val Asn Ser Asp Cys Leu Leu Asp 
            20                  25                  30          


Gly Leu Asp Ala Leu Val Tyr Asp Leu Asp Phe Pro Ala Leu Arg Lys 
        35                  40                  45              


Asn Lys Asn Ile Asp Asn Phe Leu Ser Arg Tyr Lys Asp Thr Ile Asn 
    50                  55                  60                  


Lys Ile Arg Asp Leu Arg Met Lys Ala Glu Asp Tyr Glu Val Val Lys 
65                  70                  75                  80  


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
                85                  90                  95      


Ser Thr Arg Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
            100                 105                 110         


Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
        115                 120                 125             


Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
    130                 135                 140                 


Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
145                 150                 155                 160 


Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Arg 
                165                 170                 175     


Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
            180                 185                 190         


Gly Phe Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
        195                 200                 205             


Ser Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asn 
    210                 215                 220                 


Lys Glu Gly Met Val Arg Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
225                 230                 235                 240 


Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Tyr Tyr Gly 
                245                 250                 255     


Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
            260                 265                 270         


Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
        275                 280                 285             


Lys Ile Met Asn His Lys Asn Ser Leu Thr Phe Pro Asp Asp Asn Asp 
    290                 295                 300                 


Ile Ser Lys Glu Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
305                 310                 315                 320 


Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Lys Arg His Leu 
                325                 330                 335     


Phe Phe Lys Asn Asp Gln Trp Ala Trp Glu Thr Leu Arg Asp Thr Val 
            340                 345                 350         


Ala Pro Val Val Pro Asp Leu Ser Ser Asp Ile Asp Thr Ser Asn Phe 
        355                 360                 365             


Asp Asp Leu Glu Glu Asp Lys Gly Glu Glu Glu Thr Phe Pro Ile Pro 
    370                 375                 380                 


Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Val Gly Phe Thr Tyr Tyr 
385                 390                 395                 400 


Ser Asn Arg Arg Tyr Leu Ser Ser Ala Asn Pro Asn Asp Asn Arg Thr 
                405                 410                 415     


Ser Ser Asn Ala Asp Lys Ser Leu Gln Glu Ser Leu Gln Lys Thr Ile 
            420                 425                 430         


Tyr Lys Leu Glu Glu Gln Leu His Asn Glu Met Gln Leu Lys Asp Glu 
        435                 440                 445             


Met Glu Gln Lys Cys Arg Thr Ser Asn Ile Lys Leu Asp Lys Ile Met 
    450                 455                 460                 


Lys Glu Leu Asp Glu Glu Gly Asn Gln Arg Arg Asn Leu Glu Ser Thr 
465                 470                 475                 480 


Val Ser Gln Ile Glu Lys Glu Lys Met Leu Leu Gln His Arg Ile Asn 
                485                 490                 495     


Glu Tyr Gln Arg Lys Ala Glu Gln Glu Asn Glu Lys Arg Arg Asn Val 
            500                 505                 510         


Glu Asn Glu Val Ser Thr Leu Lys Asp Gln Leu Glu Asp Leu Lys Lys 
        515                 520                 525             


Val Ser Gln Asn Ser Gln Leu Ala Asn Glu Lys Leu Ser Gln Leu Gln 
    530                 535                 540                 


Lys Gln Leu Glu Glu Ala Asn Asp Leu Leu Arg Thr Glu Ser Asp Thr 
545                 550                 555                 560 


Ala Val Arg Leu Arg Lys Ser His Thr Glu Met Ser Lys Ser Ile Ser 
                565                 570                 575     


Gln Leu Glu Ser Leu Asn Arg Glu Leu Gln Glu Arg Asn Arg Ile Leu 
            580                 585                 590         


Glu Asn Ser Lys Ser Gln Thr Asp Lys Asp Tyr Tyr Gln Leu Gln Ala 
        595                 600                 605             


Ile Leu Glu Ala Glu Arg Arg Asp Arg Gly His Asp Ser Glu Met Ile 
    610                 615                 620                 


Gly Asp Leu Gln Ala Arg Ile Thr Ser Leu Gln Glu Glu Val Lys His 
625                 630                 635                 640 


Leu Lys His Asn Leu Glu Lys Val Glu Gly Glu Arg Lys Glu Ala Gln 
                645                 650                 655     


Asp Met Leu Asn His Ser Glu Lys Glu Lys Asn Asn Leu Glu Ile Asp 
            660                 665                 670         


Leu Asn Tyr Lys Leu Lys Ser Leu Gln Gln Arg Leu Glu Gln Glu Val 
        675                 680                 685             


Asn Glu His Lys Val Thr Lys Ala Arg Leu Thr Asp Lys His Gln Ser 
    690                 695                 700                 


Ile Glu Glu Ala Lys Ser Val Ala Met Cys Glu Met Glu Lys Lys Leu 
705                 710                 715                 720 


Lys Glu Glu Arg Glu Ala Arg Glu Lys Ala Glu Asn Arg Val Val Gln 
                725                 730                 735     


Ile Glu Lys Gln Cys Ser Met Leu Asp Val Asp Leu Lys Gln Ser Gln 
            740                 745                 750         


Gln Lys Leu Glu His Leu Thr Gly Asn Lys Glu Arg Met Glu Asp Glu 
        755                 760                 765             


Val Lys Asn Leu Thr Leu Gln Leu Glu Gln Glu Ser Asn Lys Arg Leu 
    770                 775                 780                 


Leu Leu Gln Asn Glu Leu Lys Thr Gln Ala Phe Glu Ala Asp Asn Leu 
785                 790                 795                 800 


Lys Gly Leu Glu Lys Gln Met Lys Gln Glu Ile Asn Thr Leu Leu Glu 
                805                 810                 815     


Ala Lys Arg Leu Leu Glu Phe Glu Leu Ala Gln Leu Thr Lys Gln Tyr 
            820                 825                 830         


Arg Gly Asn Glu Gly Gln Met Arg Glu Leu Gln Asp Gln Leu Glu Ala 
        835                 840                 845             


Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val Lys Glu Leu Lys 
    850                 855                 860                 


Glu Glu Ile Glu Glu Lys Asn Arg Glu Asn Leu Lys Lys Ile Gln Glu 
865                 870                 875                 880 


Leu Gln Asn Glu Lys Glu Thr Leu Ala Thr Gln Leu Asp Leu Ala Glu 
                885                 890                 895     


Thr Lys Ala Glu Ser Glu Gln Leu Ala Arg Gly Leu Leu Glu Glu Gln 
            900                 905                 910         


Tyr Phe Glu Leu Thr Gln Glu Ser Lys Lys Ala Ala Ser Arg Asn Arg 
        915                 920                 925             


Gln Glu Ile Thr Asp Lys Asp His Thr Val Ser Arg Leu Glu Glu Ala 
    930                 935                 940                 


Asn Ser Met Leu Thr Lys Asp Ile Glu Ile Leu Arg Arg Glu Asn Glu 
945                 950                 955                 960 


Glu Leu Thr Glu Lys Met Lys Lys Ala Glu Glu Glu Tyr Lys Leu Glu 
                965                 970                 975     


Lys Glu Glu Glu Ile Ser Asn Leu Lys Ala Ala Phe Glu Lys Asn Ile 
            980                 985                 990         


Asn Thr Glu Arg Thr Leu Lys Thr  Gln Ala Val Asn Lys  Leu Ala Glu 
        995                 1000                 1005             


Ile Met  Asn Arg Lys Asp Phe  Lys Ile Asp Arg Lys  Lys Ala Asn 
    1010                 1015                 1020             


Thr Gln  Asp Leu Arg Lys Lys  Glu Lys Glu Asn Arg  Lys Leu Gln 
    1025                 1030                 1035             


Leu Glu  Leu Asn Gln Glu Arg  Glu Lys Phe Asn Gln  Met Val Val 
    1040                 1045                 1050             


Lys His  Gln Lys Glu Leu Asn  Asp Met Gln Ala Gln  Leu Val Glu 
    1055                 1060                 1065             


Glu Cys  Ala His Arg Asn Glu  Leu Gln Met Gln Leu  Ala Ser Lys 
    1070                 1075                 1080             


Glu Ser  Asp Ile Glu Gln Leu  Arg Ala Lys Leu Leu  Asp Leu Ser 
    1085                 1090                 1095             


Asp Ser  Thr Ser Val Ala Ser  Phe Pro Ser Ala Asp  Glu Thr Asp 
    1100                 1105                 1110             


Gly Asn  Leu Pro Glu Ser Arg  Ile Glu Gly Trp Leu  Ser Val Pro 
    1115                 1120                 1125             


Asn Arg  Gly Asn Ile Lys Arg  Tyr Gly Trp Lys Lys  Gln Tyr Val 
    1130                 1135                 1140             


Val Val  Ser Ser Lys Lys Ile  Leu Phe Tyr Asn Asp  Glu Gln Asp 
    1145                 1150                 1155             


Lys Glu  Gln Ser Asn Pro Ser  Met Val Leu Asp Ile  Asp Lys Leu 
    1160                 1165                 1170             


Phe His  Val Arg Pro Val Thr  Gln Gly Asp Val Tyr  Arg Ala Glu 
    1175                 1180                 1185             


Thr Glu  Glu Ile Pro Lys Ile  Phe Gln Ile Leu Tyr  Ala Asn Glu 
    1190                 1195                 1200             


Gly Glu  Cys Arg Lys Asp Val  Glu Met Glu Pro Val  Gln Gln Ala 
    1205                 1210                 1215             


Glu Lys  Thr Asn Phe Gln Asn  His Lys Gly His Glu  Phe Ile Pro 
    1220                 1225                 1230             


Thr Leu  Tyr His Phe Pro Ala  Asn Cys Asp Ala Cys  Ala Lys Pro 
    1235                 1240                 1245             


Leu Trp  His Val Phe Lys Pro  Pro Pro Ala Leu Glu  Cys Arg Arg 
    1250                 1255                 1260             


Cys His  Val Lys Cys His Arg  Asp His Leu Asp Lys  Lys Glu Asp 
    1265                 1270                 1275             


Leu Ile  Cys Pro Cys Lys Val  Ser Tyr Asp Val Thr  Ser Ala Arg 
    1280                 1285                 1290             


Asp Met  Leu Leu Leu Ala Cys  Ser Gln Asp Glu Gln  Lys Lys Trp 
    1295                 1300                 1305             


Val Thr  His Leu Val Lys Lys  Ile Pro Lys Asn Pro  Pro Ser Gly 
    1310                 1315                 1320             


Phe Val  Arg Ala Ser Pro Arg  Thr Leu Ser Thr Arg  Ser Thr Ala 
    1325                 1330                 1335             


Asn Gln  Ser Phe Arg Lys Val  Val Lys Asn Thr Ser  Gly Lys Thr 
    1340                 1345                 1350             


Ser 
    


<210>  24
<211>  1388
<212>  PRT
<213>  homo sapiens

<400>  24

Met Ser Arg Pro Pro Pro Thr Gly Lys Met Pro Gly Ala Pro Glu Thr 
1               5                   10                  15      


Ala Pro Gly Asp Gly Ala Gly Ala Ser Arg Gln Arg Lys Leu Glu Ala 
            20                  25                  30          


Leu Ile Arg Asp Pro Arg Ser Pro Ile Asn Val Glu Ser Leu Leu Asp 
        35                  40                  45              


Gly Leu Asn Ser Leu Val Leu Asp Leu Asp Phe Pro Ala Leu Arg Lys 
    50                  55                  60                  


Asn Lys Asn Ile Asp Asn Phe Leu Asn Arg Tyr Glu Lys Ile Val Lys 
65                  70                  75                  80  


Lys Ile Arg Gly Leu Gln Met Lys Ala Glu Asp Tyr Asp Val Val Lys 
                85                  90                  95      


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
            100                 105                 110         


Ala Ser Gln Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
        115                 120                 125             


Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
    130                 135                 140                 


Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
145                 150                 155                 160 


Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
                165                 170                 175     


Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys 
            180                 185                 190         


Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
        195                 200                 205             


Gly Leu Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
    210                 215                 220                 


His Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asp 
225                 230                 235                 240 


Glu Thr Gly Met Val His Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
                245                 250                 255     


Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly 
            260                 265                 270         


Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
        275                 280                 285             


Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
    290                 295                 300                 


Lys Ile Met Asp His Lys Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu 
305                 310                 315                 320 


Ile Ser Lys His Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
                325                 330                 335     


Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Arg Gln His Pro 
            340                 345                 350         


Phe Phe Lys Asn Asp Gln Trp His Trp Asp Asn Ile Arg Glu Thr Ala 
        355                 360                 365             


Ala Pro Val Val Pro Glu Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe 
    370                 375                 380                 


Asp Asp Ile Glu Asp Asp Lys Gly Asp Val Glu Thr Phe Pro Ile Pro 
385                 390                 395                 400 


Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr 
                405                 410                 415     


Arg Glu Asn Leu Leu Leu Ser Asp Ser Pro Ser Cys Arg Glu Thr Asp 
            420                 425                 430         


Ser Ile Gln Ser Arg Lys Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys 
        435                 440                 445             


Leu Tyr Thr Leu Glu Glu His Leu Ser Asn Glu Met Gln Ala Lys Glu 
    450                 455                 460                 


Glu Leu Glu Gln Lys Cys Lys Ser Val Asn Thr Arg Leu Glu Lys Thr 
465                 470                 475                 480 


Ala Lys Glu Leu Glu Glu Glu Ile Thr Leu Arg Lys Ser Val Glu Ser 
                485                 490                 495     


Ala Leu Arg Gln Leu Glu Arg Glu Lys Ala Leu Leu Gln His Lys Asn 
            500                 505                 510         


Ala Glu Tyr Gln Arg Lys Ala Asp His Glu Ala Asp Lys Lys Arg Asn 
        515                 520                 525             


Leu Glu Asn Asp Val Asn Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys 
    530                 535                 540                 


Lys Arg Asn Gln Asn Ser Gln Ile Ser Thr Glu Lys Val Asn Gln Leu 
545                 550                 555                 560 


Gln Arg Gln Leu Asp Glu Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp 
                565                 570                 575     


Thr Ala Ala Arg Leu Arg Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile 
            580                 585                 590         


Gln Gln Leu Glu Ser Asn Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu 
        595                 600                 605             


Leu Glu Thr Ala Lys Leu Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln 
    610                 615                 620                 


Ser Ala Leu Glu Ser Glu Arg Arg Asp Arg Thr His Gly Ser Glu Ile 
625                 630                 635                 640 


Ile Asn Asp Leu Gln Gly Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys 
                645                 650                 655     


Asn Gly Lys Ile Leu Leu Ala Lys Val Glu Leu Glu Lys Arg Gln Leu 
            660                 665                 670         


Gln Glu Arg Phe Thr Asp Leu Glu Lys Glu Lys Ser Asn Met Glu Ile 
        675                 680                 685             


Asp Met Thr Tyr Gln Leu Lys Val Ile Gln Gln Ser Leu Glu Gln Glu 
    690                 695                 700                 


Glu Ala Glu His Lys Ala Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys 
705                 710                 715                 720 


Ile Tyr Glu Ser Ile Glu Glu Ala Lys Ser Glu Ala Met Lys Glu Met 
                725                 730                 735     


Glu Lys Lys Leu Leu Glu Glu Arg Thr Leu Lys Gln Lys Val Glu Asn 
            740                 745                 750         


Leu Leu Leu Glu Ala Glu Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu 
        755                 760                 765             


Lys Gln Ser Gln Gln Lys Ile Asn Glu Leu Leu Lys Gln Lys Asp Val 
    770                 775                 780                 


Leu Asn Glu Asp Val Arg Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr 
785                 790                 795                 800 


Gln Lys Arg Cys Leu Thr Gln Asn Asp Leu Lys Met Gln Thr Gln Gln 
                805                 810                 815     


Val Asn Thr Leu Lys Met Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn 
            820                 825                 830         


His Leu Met Glu Met Lys Met Asn Leu Glu Lys Gln Asn Ala Glu Leu 
        835                 840                 845             


Arg Lys Glu Arg Gln Asp Ala Asp Gly Gln Met Lys Glu Leu Gln Asp 
    850                 855                 860                 


Gln Leu Glu Ala Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val 
865                 870                 875                 880 


Arg Glu Leu Lys Glu Glu Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu 
                885                 890                 895     


Leu Gln Gln Lys Lys Gln Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala 
            900                 905                 910         


Ala Gln Leu Glu Ile Thr Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala 
        915                 920                 925             


Arg Ser Ile Ala Glu Glu Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile 
    930                 935                 940                 


Met Lys Glu Leu Glu Ile Lys Glu Met Met Ala Arg His Lys Gln Glu 
945                 950                 955                 960 


Leu Thr Glu Lys Asp Ala Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg 
                965                 970                 975     


Thr Leu Thr Ser Asp Val Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu 
            980                 985                 990         


Asn Asn Lys Leu Lys Asp Val Gln  Glu Gln Leu Ser Arg  Leu Lys Asp 
        995                 1000                 1005             


Glu Glu  Ile Ser Ala Ala Ala  Ile Lys Ala Gln Phe  Glu Lys Gln 
    1010                 1015                 1020             


Leu Leu  Thr Glu Arg Thr Leu  Lys Thr Gln Ala Val  Asn Lys Leu 
    1025                 1030                 1035             


Ala Glu  Ile Met Asn Arg Lys  Glu Pro Val Lys Arg  Gly Asn Asp 
    1040                 1045                 1050             


Thr Asp  Val Arg Arg Lys Glu  Lys Glu Asn Arg Lys  Leu His Met 
    1055                 1060                 1065             


Glu Leu  Lys Ser Glu Arg Glu  Lys Leu Thr Gln Gln  Met Ile Lys 
    1070                 1075                 1080             


Tyr Gln  Lys Glu Leu Asn Glu  Met Gln Ala Gln Ile  Ala Glu Glu 
    1085                 1090                 1095             


Ser Gln  Ile Arg Ile Glu Leu  Gln Met Thr Leu Asp  Ser Lys Asp 
    1100                 1105                 1110             


Ser Asp  Ile Glu Gln Leu Arg  Ser Gln Leu Gln Ala  Leu His Ile 
    1115                 1120                 1125             


Gly Leu  Asp Ser Ser Ser Ile  Gly Ser Gly Pro Gly  Asp Ala Glu 
    1130                 1135                 1140             


Ala Asp  Asp Gly Phe Pro Glu  Ser Arg Leu Glu Gly  Trp Leu Ser 
    1145                 1150                 1155             


Leu Pro  Val Arg Asn Asn Thr  Lys Lys Phe Gly Trp  Val Lys Lys 
    1160                 1165                 1170             


Tyr Val  Ile Val Ser Ser Lys  Lys Ile Leu Phe Tyr  Asp Ser Glu 
    1175                 1180                 1185             


Gln Asp  Lys Glu Gln Ser Asn  Pro Tyr Met Val Leu  Asp Ile Asp 
    1190                 1195                 1200             


Lys Leu  Phe His Val Arg Pro  Val Thr Gln Thr Asp  Val Tyr Arg 
    1205                 1210                 1215             


Ala Asp  Ala Lys Glu Ile Pro  Arg Ile Phe Gln Ile  Leu Tyr Ala 
    1220                 1225                 1230             


Asn Glu  Gly Glu Ser Lys Lys  Glu Gln Glu Phe Pro  Val Glu Pro 
    1235                 1240                 1245             


Val Gly  Glu Lys Ser Asn Tyr  Ile Cys His Lys Gly  His Glu Phe 
    1250                 1255                 1260             


Ile Pro  Thr Leu Tyr His Phe  Pro Thr Asn Cys Glu  Ala Cys Met 
    1265                 1270                 1275             


Lys Pro  Leu Trp His Met Phe  Lys Pro Pro Pro Ala  Leu Glu Cys 
    1280                 1285                 1290             


Arg Arg  Cys His Ile Lys Cys  His Lys Asp His Met  Asp Lys Lys 
    1295                 1300                 1305             


Glu Glu  Ile Ile Ala Pro Cys  Lys Val Tyr Tyr Asp  Ile Ser Thr 
    1310                 1315                 1320             


Ala Lys  Asn Leu Leu Leu Leu  Ala Asn Ser Thr Glu  Glu Gln Gln 
    1325                 1330                 1335             


Lys Trp  Val Ser Arg Leu Val  Lys Lys Ile Pro Lys  Lys Pro Pro 
    1340                 1345                 1350             


Ala Pro  Asp Pro Phe Ala Arg  Ser Ser Pro Arg Thr  Ser Met Lys 
    1355                 1360                 1365             


Ile Gln  Gln Asn Gln Ser Ile  Arg Arg Pro Ser Arg  Gln Leu Ala 
    1370                 1375                 1380             


Pro Asn  Lys Pro Ser 
    1385             


<210>  25
<211>  427
<212>  PRT
<213>  homo sapiens

<400>  25

Met Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 
        35                  40                  45              


Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Leu 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Met Val Cys His Lys Ile Leu 
    210                 215                 220                 


Phe Pro Gly Arg Asp Tyr Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 
            260                 265                 270         


Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 
        275                 280                 285             


Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 
305                 310                 315                 320 


Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 
                325                 330                 335     


Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 
        355                 360                 365             


Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Gly Ala Ala Val Ile 
    370                 375                 380                 


Asn Gly Ser Gln His Pro Ser Ser Ser Ser Ser Val Asn Asp Val Ser 
385                 390                 395                 400 


Ser Met Ser Thr Asp Pro Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu 
                405                 410                 415     


Glu Ala Ala Ala Gly Pro Leu Gly Cys Cys Arg 
            420                 425         


<210>  26
<211>  427
<212>  PRT
<213>  homo sapiens

<400>  26

Met Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 
        35                  40                  45              


Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Met Ile Lys Gly Gly Val Leu 
    210                 215                 220                 


Phe Pro Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 
            260                 265                 270         


Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 
        275                 280                 285             


Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 
305                 310                 315                 320 


Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 
                325                 330                 335     


Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 
        355                 360                 365             


Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Gly Ala Ala Val Ile 
    370                 375                 380                 


Asn Gly Ser Gln His Pro Ser Ser Ser Ser Ser Val Asn Asp Val Ser 
385                 390                 395                 400 


Ser Met Ser Thr Asp Pro Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu 
                405                 410                 415     


Glu Ala Ala Ala Gly Pro Leu Gly Cys Cys Arg 
            420                 425         


<210>  27
<211>  384
<212>  PRT
<213>  homo sapiens

<400>  27

Met Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 
        35                  40                  45              


Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Met Ile Lys Gly Gly Val Leu 
    210                 215                 220                 


Phe Pro Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 
            260                 265                 270         


Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 
        275                 280                 285             


Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 
305                 310                 315                 320 


Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 
                325                 330                 335     


Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 
        355                 360                 365             


Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Ala Gln Val Gln Gln 
    370                 375                 380                 


<210>  28
<211>  384
<212>  PRT
<213>  homo sapiens

<400>  28

Met Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 
        35                  40                  45              


Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Leu 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Met Val Cys His Lys Ile Leu 
    210                 215                 220                 


Phe Pro Gly Arg Asp Tyr Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 
            260                 265                 270         


Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 
        275                 280                 285             


Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 
305                 310                 315                 320 


Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 
                325                 330                 335     


Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 
        355                 360                 365             


Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Ala Gln Val Gln Gln 
    370                 375                 380                 


<210>  29
<211>  379
<212>  PRT
<213>  homo sapiens

<400>  29

Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 
1               5                   10                  15      


Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 
            20                  25                  30          


Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 
        35                  40                  45              


Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 
    50                  55                  60                  


Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 
65                  70                  75                  80  


Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 
                85                  90                  95      


His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 
            100                 105                 110         


Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 
        115                 120                 125             


Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 
    130                 135                 140                 


Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
145                 150                 155                 160 


Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 
                165                 170                 175     


Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 
            180                 185                 190         


Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 
        195                 200                 205             


Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 
    210                 215                 220                 


Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 
                245                 250                 255     


Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile 
            260                 265                 270         


Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr 
        275                 280                 285             


Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala Leu 
    290                 295                 300                 


Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys Arg Ile Thr 
305                 310                 315                 320 


Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro 
                325                 330                 335     


Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe Ala Met Glu Leu 
            340                 345                 350         


Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile Phe Gln Glu Thr 
        355                 360                 365             


Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro 
    370                 375                 


<210>  30
<211>  357
<212>  PRT
<213>  homo sapiens

<400>  30

Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 
1               5                   10                  15      


Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 
            20                  25                  30          


Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 
        35                  40                  45              


Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 
    50                  55                  60                  


Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 
65                  70                  75                  80  


Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 
                85                  90                  95      


His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 
            100                 105                 110         


Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 
        115                 120                 125             


Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 
    130                 135                 140                 


Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
145                 150                 155                 160 


Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 
                165                 170                 175     


Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 
            180                 185                 190         


Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 
        195                 200                 205             


Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 
    210                 215                 220                 


Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 
                245                 250                 255     


Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile 
            260                 265                 270         


Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr 
        275                 280                 285             


Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala Leu 
    290                 295                 300                 


Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys Arg Ile Thr 
305                 310                 315                 320 


Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro 
                325                 330                 335     


Thr Asp Glu Val Gly Gln Ser Pro Ala Ala Val Gly Leu Gly Ala Gly 
            340                 345                 350         


Glu Gln Gly Gly Thr 
        355         


<210>  31
<211>  335
<212>  PRT
<213>  homo sapiens

<400>  31

Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 
1               5                   10                  15      


Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 
            20                  25                  30          


Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 
        35                  40                  45              


Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 
    50                  55                  60                  


Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 
65                  70                  75                  80  


Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 
                85                  90                  95      


His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 
            100                 105                 110         


Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 
        115                 120                 125             


Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 
    130                 135                 140                 


Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
145                 150                 155                 160 


Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 
                165                 170                 175     


Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 
            180                 185                 190         


Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 
        195                 200                 205             


Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 
    210                 215                 220                 


Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 
                245                 250                 255     


Ile Leu Ala Leu Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn 
            260                 265                 270         


Lys Arg Ile Thr Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln 
        275                 280                 285             


Tyr Tyr Asp Pro Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe 
    290                 295                 300                 


Ala Met Glu Leu Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile 
305                 310                 315                 320 


Phe Gln Glu Thr Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro 
                325                 330                 335 


<210>  32
<211>  6774
<212>  DNA
<213>  homo sapiens

<400>  32
cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc       60

gcgggaggct ggtgggtgtg gggggtggag atgtagaaga tgtgacgccg cggcccggcg      120

ggtgccagat tagcggacgc ggtgcccgcg gttgcaacgg gatcccgggc gctgcagctt      180

gggaggcggc tctccccagg cggcgtccgc ggagacaccc atccgtgaac cccaggtccc      240

gggccgccgg ctcgccgcgc accaggggcc ggcggacaga agagcggccg agcggctcga      300

ggctggggga ccgcgggcgc ggccgcgcgc tgccgggcgg gaggctgggg ggccggggcc      360

ggggccgtgc cccggagcgg gtcggaggcc ggggccgggg ccgggggacg gcggctcccc      420

gcgcggctcc agcggctcgg ggatcccggc cgggccccgc agggaccatg gcagccggga      480

gcatcaccac gctgcccgcc ttgcccgagg atggcggcag cggcgccttc ccgcccggcc      540

acttcaagga ccccaagcgg ctgtactgca aaaacggggg cttcttcctg cgcatccacc      600

ccgacggccg agttgacggg gtccgggaga agagcgaccc tcacatcaag ctacaacttc      660

aagcagaaga gagaggagtt gtgtctatca aaggagtgtg tgctaaccgt tacctggcta      720

tgaaggaaga tggaagatta ctggcttcta aatgtgttac ggatgagtgt ttcttttttg      780

aacgattgga atctaataac tacaatactt accggtcaag gaaatacacc agttggtatg      840

tggcactgaa acgaactggg cagtataaac ttggatccaa aacaggacct gggcagaaag      900

ctatactttt tcttccaatg tctgctaaga gctgatttta atggccacat ctaatctcat      960

ttcacatgaa agaagaagta tattttagaa atttgttaat gagagtaaaa gaaaataaat     1020

gtgtatagct cagtttggat aattggtcaa acaatttttt atccagtagt aaaatatgta     1080

accattgtcc cagtaaagaa aaataacaaa agttgtaaaa tgtatattct cccttttata     1140

ttgcatctgc tgttacccag tgaagcttac ctagagcaat gatctttttc acgcatttgc     1200

tttattcgaa aagaggcttt taaaatgtgc atgtttagaa acaaaatttc ttcatggaaa     1260

tcatatacat tagaaaatca cagtcagatg tttaatcaat ccaaaatgtc cactatttct     1320

tatgtcattc gttagtctac atgtttctaa acatataaat gtgaatttaa tcaattcctt     1380

tcatagtttt ataattctct ggcagttcct tatgatagag tttataaaac agtcctgtgt     1440

aaactgctgg aagttcttcc acagtcaggt caattttgtc aaacccttct ctgtacccat     1500

acagcagcag cctagcaact ctgctggtga tgggagttgt attttcagtc ttcgccaggt     1560

cattgagatc catccactca catcttaagc attcttcctg gcaaaaattt atggtgaatg     1620

aatatggctt taggcggcag atgatataca tatctgactt cccaaaagct ccaggatttg     1680

tgtgctgttg ccgaatactc aggacggacc tgaattctga ttttatacca gtctcttcaa     1740

aaacttctcg aaccgctgtg tctcctacgt aaaaaaagag atgtacaaat caataataat     1800

tacactttta gaaactgtat catcaaagat tttcagttaa agtagcatta tgtaaaggct     1860

caaaacatta ccctaacaaa gtaaagtttt caatacaaat tctttgcctt gtggatatca     1920

agaaatccca aaatattttc ttaccactgt aaattcaaga agcttttgaa atgctgaata     1980

tttctttggc tgctacttgg aggcttatct acctgtacat ttttggggtc agctcttttt     2040

aacttcttgc tgctcttttt cccaaaaggt aaaaatatag attgaaaagt taaaacattt     2100

tgcatggctg cagttccttt gtttcttgag ataagattcc aaagaactta gattcatttc     2160

ttcaacaccg aaatgctgga ggtgtttgat cagttttcaa gaaacttgga atataaataa     2220

ttttataatt caacaaaggt tttcacattt tataaggttg atttttcaat taaatgcaaa     2280

tttgtgtggc aggattttta ttgccattaa catatttttg tggctgcttt ttctacacat     2340

ccagatggtc cctctaactg ggctttctct aattttgtga tgttctgtca ttgtctccca     2400

aagtatttag gagaagccct ttaaaaagct gccttcctct accactttgc tggaaagctt     2460

cacaattgtc acagacaaag atttttgttc caatactcgt tttgcctcta tttttcttgt     2520

ttgtcaaata gtaaatgata tttgcccttg cagtaattct actggtgaaa aacatgcaaa     2580

gaagaggaag tcacagaaac atgtctcaat tcccatgtgc tgtgactgta gactgtctta     2640

ccatagactg tcttacccat cccctggata tgctcttgtt ttttccctct aatagctatg     2700

gaaagatgca tagaaagagt ataatgtttt aaaacataag gcattcgtct gccatttttc     2760

aattacatgc tgacttccct tacaattgag atttgcccat aggttaaaca tggttagaaa     2820

caactgaaag cataaaagaa aaatctaggc cgggtgcagt ggctcatgcc tatattccct     2880

gcactttggg aggccaaagc aggaggatcg cttgagccca ggagttcaag accaacctgg     2940

tgaaaccccg tctctacaaa aaaacacaaa aaatagccag gcatggtggc gtgtacatgt     3000

ggtctcagat acttgggagg ctgaggtggg agggttgatc acttgaggct gagaggtcaa     3060

ggttgcagtg agccataatc gtgccactgc agtccagcct aggcaacaga gtgagacttt     3120

gtctcaaaaa aagagaaatt ttccttaata agaaaagtaa tttttactct gatgtgcaat     3180

acatttgtta ttaaatttat tatttaagat ggtagcacta gtcttaaatt gtataaaata     3240

tcccctaaca tgtttaaatg tccattttta ttcattatgc tttgaaaaat aattatgggg     3300

aaatacatgt ttgttattaa atttattatt aaagatagta gcactagtct taaatttgat     3360

ataacatctc ctaacttgtt taaatgtcca tttttattct ttatgtttga aaataaatta     3420

tggggatcct atttagctct tagtaccact aatcaaaagt tcggcatgta gctcatgatc     3480

tatgctgttt ctatgtcgtg gaagcaccgg atgggggtag tgagcaaatc tgccctgctc     3540

agcagtcacc atagcagctg actgaaaatc agcactgcct gagtagtttt gatcagttta     3600

acttgaatca ctaactgact gaaaattgaa tgggcaaata agtgcttttg tctccagagt     3660

atgcgggaga cccttccacc tcaagatgga tatttcttcc ccaaggattt caagatgaat     3720

tgaaattttt aatcaagata gtgtgcttta ttctgttgta ttttttatta ttttaatata     3780

ctgtaagcca aactgaaata acatttgctg ttttataggt ttgaagaaca taggaaaaac     3840

taagaggttt tgtttttatt tttgctgatg aagagatatg tttaaatatg ttgtattgtt     3900

ttgtttagtt acaggacaat aatgaaatgg agtttatatt tgttatttct attttgttat     3960

atttaataat agaattagat tgaaataaaa tataatggga aataatctgc agaatgtggg     4020

ttttcctggt gtttccctct gactctagtg cactgatgat ctctgataag gctcagctgc     4080

tttatagttc tctggctaat gcagcagata ctcttcctgc cagtggtaat acgatttttt     4140

aagaaggcag tttgtcaatt ttaatcttgt ggataccttt atactcttag ggtattattt     4200

tatacaaaag ccttgaggat tgcattctat tttctatatg accctcttga tatttaaaaa     4260

acactatgga taacaattct tcatttacct agtattatga aagaatgaag gagttcaaac     4320

aaatgtgttt cccagttaac tagggtttac tgtttgagcc aatataaatg tttaactgtt     4380

tgtgatggca gtattcctaa agtacattgc atgttttcct aaatacagag tttaaataat     4440

ttcagtaatt cttagatgat tcagcttcat cattaagaat atcttttgtt ttatgttgag     4500

ttagaaatgc cttcatatag acatagtctt tcagacctct actgtcagtt ttcatttcta     4560

gctgctttca gggttttatg aattttcagg caaagcttta atttatacta agcttaggaa     4620

gtatggctaa tgccaacggc agtttttttc ttcttaattc cacatgactg aggcatatat     4680

gatctctggg taggtgagtt gttgtgacaa ccacaagcac tttttttttt tttaaagaaa     4740

aaaaggtagt gaatttttaa tcatctggac tttaagaagg attctggagt atacttaggc     4800

ctgaaattat atatatttgg cttggaaatg tgtttttctt caattacatc tacaagtaag     4860

tacagctgaa attcagagga cccataagag ttcacatgaa aaaaatcaat ttatttgaaa     4920

aggcaagatg caggagagag gaagccttgc aaacctgcag actgcttttt gcccaatata     4980

gattgggtaa ggctgcaaaa cataagctta attagctcac atgctctgct ctcacgtggc     5040

accagtggat agtgtgagag aattaggctg tagaacaaat ggccttctct ttcagcattc     5100

acaccactac aaaatcatct tttatatcaa cagaagaata agcataaact aagcaaaagg     5160

tcaataagta cctgaaacca agattggcta gagatatatc ttaatgcaat ccattttctg     5220

atggattgtt acgagttggc tatataatgt atgtatggta ttttgatttg tgtaaaagtt     5280

ttaaaaatca agctttaagt acatggacat ttttaaataa aatatttaaa gacaatttag     5340

aaaattgcct taatatcatt gttggctaaa tagaataggg gacatgcata ttaaggaaaa     5400

ggtcatggag aaataatatt ggtatcaaac aaatacattg atttgtcatg atacacattg     5460

aatttgatcc aatagtttaa ggaataggta ggaaaatttg gtttctattt ttcgatttcc     5520

tgtaaatcag tgacataaat aattcttagc ttattttata tttccttgtc ttaaatactg     5580

agctcagtaa gttgtgttag gggattattt ctcagttgag actttcttat atgacatttt     5640

actatgtttt gacttcctga ctattaaaaa taaatagtag atacaatttt cataaagtga     5700

agaattatat aatcactgct ttataactga ctttattata tttatttcaa agttcattta     5760

aaggctacta ttcatcctct gtgatggaat ggtcaggaat ttgttttctc atagtttaat     5820

tccaacaaca atattagtcg tatccaaaat aacctttaat gctaaacttt actgatgtat     5880

atccaaagct tctcattttc agacagatta atccagaagc agtcataaac agaagaatag     5940

gtggtatgtt cctaatgata ttatttctac taatggaata aactgtaata ttagaaatta     6000

tgctgctaat tatatcagct ctgaggtaat ttctgaaatg ttcagactca gtcggaacaa     6060

attggaaaat ttaaattttt attcttagct ataaagcaag aaagtaaaca cattaatttc     6120

ctcaacattt ttaagccaat taaaaatata aaagatacac accaatatct tcttcaggct     6180

ctgacaggcc tcctggaaac ttccacatat ttttcaactg cagtataaag tcagaaaata     6240

aagttaacat aactttcact aacacacaca tatgtagatt tcacaaaatc cacctataat     6300

tggtcaaagt ggttgagaat atatttttta gtaattgcat gcaaaatttt tctagcttcc     6360

atcctttctc cctcgtttct tctttttttg ggggagctgg taactgatga aatcttttcc     6420

caccttttct cttcaggaaa tataagtggt tttgtttggt taacgtgata cattctgtat     6480

gaatgaaaca ttggagggaa acatctactg aatttctgta atttaaaata ttttgctgct     6540

agttaactat gaacagatag aagaatctta cagatgctgc tataaataag tagaaaatat     6600

aaatttcatc actaaaatat gctattttaa aatctatttc ctatattgta tttctaatca     6660

gatgtattac tcttattatt tctattgtat gtgttaatga ttttatgtaa aaatgtaatt     6720

gcttttcatg agtagtatga ataaaattga ttagtttgtg ttttcttgtc tccc           6774


<210>  33
<211>  223
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (102)..(103)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (134)..(134)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (151)..(151)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (158)..(158)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (165)..(165)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (167)..(167)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (171)..(171)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (176)..(176)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (180)..(180)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (182)..(182)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (193)..(193)
<223>  n is a, c, g, or t

<400>  33
maaaaaagag mvrgvdvgry tnsyggaygm vcsaydnvnk vrvakkshty crtrkrrhng       60

ndratmkdvy vdmtdykkth sndhcyyrgk yhsanvhrdk snnttcdkcd garvaddhdh      120

tgtyvatrwy ramnskgytk sdwsvgcams nrgkhydnhg gssdncnkar nyshknkvwn      180

rnadskaddk mtnhkrvaah yyydsdaakd mddkkktarg yrs                        223


<210>  34
<211>  223
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (102)..(103)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (134)..(134)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (151)..(151)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (158)..(158)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (165)..(165)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (167)..(167)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (171)..(171)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (176)..(176)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (180)..(180)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (182)..(182)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (193)..(193)
<223>  n is a, c, g, or t

<400>  34
maaaaaagag mvrgvdvgry tnsyggaygm vcsaydnvnk vrvakkshty crtrkrrhng       60

ndratmkdvy vdmtdykkth sndhcyyrgk yhsanvhrdk snnttcdkcd garvaddhdh      120

tgtyvatrwy ramnskgytk sdwsvgcams nrgkhydnhg gssdncnkar nyshknkvwn      180

rnadskaddk mtnhkrvaah yyydsdaakd mddkkktarg yrs                        223


<210>  35
<211>  2175
<212>  DNA
<213>  homo sapiens

<400>  35
agtacagtat aaaacttcac agtgccaata ccatgaagag gagctcagac agctcttacc       60

acatgataca agagccggct ggtggaagag tggggaccag aaagagaatt tgctgaagag      120

gagaaggaaa aaaaaaacac caaaaaaaaa aataaaaaaa tccacacaca caaaaaaacc      180

tgcgcgtgag gggggaggaa aagcagggcc ttttaaaaag gcaatcacaa caacttttgc      240

tgccaggatg cccttgcttt ggctgagagg atttctgttg gcaagttgct ggattatagt      300

gaggagttcc cccaccccag gatccgaggg gcacagcgcg gcccccgact gtccgtcctg      360

tgcgctggcc gccctcccaa aggatgtacc caactctcag ccagagatgg tggaggccgt      420

caagaagcac attttaaaca tgctgcactt gaagaagaga cccgatgtca cccagccggt      480

acccaaggcg gcgcttctga acgcgatcag aaagcttcat gtgggcaaag tcggggagaa      540

cgggtatgtg gagatagagg atgacattgg aaggagggca gaaatgaatg aacttatgga      600

gcagacctcg gagatcatca cgtttgccga gtcaggaaca gccaggaaga cgctgcactt      660

cgagatttcc aaggaaggca gtgacctgtc agtggtggag cgtgcagaag tctggctctt      720

cctaaaagtc cccaaggcca acaggaccag gaccaaagtc accatccgcc tcttccagca      780

gcagaagcac ccgcagggca gcttggacac aggggaagag gccgaggaag tgggcttaaa      840

gggggagagg agtgaactgt tgctctctga aaaagtagta gacgctcgga agagcacctg      900

gcatgtcttc cctgtctcca gcagcatcca gcggttgctg gaccagggca agagctccct      960

ggacgttcgg attgcctgtg agcagtgcca ggagagtggc gccagcttgg ttctcctggg     1020

caagaagaag aagaaagaag aggaggggga agggaaaaag aagggcggag gtgaaggtgg     1080

ggcaggagca gatgaggaaa aggagcagtc gcacagacct ttcctcatgc tgcaggcccg     1140

gcagtctgaa gaccaccctc atcgccggcg tcggcggggc ttggagtgtg atggcaaggt     1200

caacatctgc tgtaagaaac agttctttgt cagtttcaag gacatcggct ggaatgactg     1260

gatcattgct ccctctggct atcatgccaa ctactgcgag ggtgagtgcc cgagccatat     1320

agcaggcacg tccgggtcct cactgtcctt ccactcaaca gtcatcaacc actaccgcat     1380

gcggggccat agcccctttg ccaacctcaa atcgtgctgt gtgcccacca agctgagacc     1440

catgtccatg ttgtactatg atgatggtca aaacatcatc aaaaaggaca ttcagaacat     1500

gatcgtggag gagtgtgggt gctcatagag ttgcccagcc cagggggaaa gggagcaaga     1560

gttgtccaga gaagacagtg gcaaaatgaa gaaattttta aggtttctga gttaaccaga     1620

aaaatagaaa ttaaaaacaa aacaaaaaaa aaaacaaaaa aaaacaaaag taaattaaaa     1680

acaaaacctg atgaaacaga tgaaggaaga tgtggaaaaa atccttagcc agggctcaga     1740

gatgaagcag tgaaagagac aggaattggg agggaaaggg agaatggtgt accctttatt     1800

tcttctgaaa tcacactgat gacatcagtt gtttaaacgg ggtattgtcc tttcccccct     1860

tgaggttccc ttgtgagcct tgaatcaacc aatctagtct gcagtagtgt ggactagaac     1920

aacccaaata gcatctagaa agccatgagt ttgaaagggc ccatcacagg cactttccta     1980

cccaattacc caggtcataa ggtatgtctg tgtgacactt atctctgtgt atatcagcat     2040

acacacacac acacacacac acacacacac acacaggcat ttccacacat tacatatata     2100

cacatactgg taaaagaaca atcgtgtgca ggtggtcaca cttccttttt ctgtaccact     2160

tttgcaacaa aacaa                                                      2175


<210>  36
<211>  426
<212>  PRT
<213>  homo sapiens

<400>  36

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  37
<211>  19296
<212>  DNA
<213>  homo sapiens

<400>  37
ccttcagttc ttaaagcgct gcaattcgct gctgcagcca tatttcttac tctctcgggg       60

ctggaagctt cctgactgaa gatctctctg cacttggggt tctttctaga acattttcta      120

gtcccccaac accctttatg gcgtatttct ttaaaaaaat cacctaaatt ccataaaata      180

tttttttaaa ttctatactt tctcctagtg tcttcttgac acgtcctcca tattttttta      240

aagaaagtat ttggaatatt ttgaggcaat ttttaatatt taaggaattt ttctttggaa      300

tcatttttgg ttgacatctc tgttttttgt ggatcagttt tttactcttc cactctcttt      360

tctatatttt gcccatcggg gctgcggata cctggtttta ttattttttc tttgcccaac      420

ggggccgtgg atacctgcct tttaattctt ttttattcgc ccatcggggc cgcggatacc      480

tgctttttat ttttttttcc ttagcccatc ggggtatcgg atacctgctg attcccttcc      540

cctctgaacc cccaacactc tggcccatcg gggtgacgga tatctgcttt ttaaaaattt      600

tctttttttg gcccatcggg gcttcggata cctgcttttt ttttttttat ttttccttgc      660

ccatcggggc ctcggatacc tgctttaatt tttgtttttc tggcccatcg gggccgcgga      720

tacctgcttt gatttttttt tttcatcgcc catcggtgct ttttatggat gaaaaaatgt      780

tggttttgtg ggttgttgca ctctctggaa tatctacact tttttttgct gctgatcatt      840

tggtggtgtg tgagtgtacc taccgctttg gcagagaatg actctgcagt taagctaagg      900

gcgtgttcag attgtggagg aaaagtggcc gccattttag acttgccgca taactcggct      960

tagggctagt cgtttgtgct aagttaaact agggaggcaa gatggatgat agcaggtcag     1020

gcagaggaag tcatgtgcat tgcatgagct aaacctatct gaatgaattg atttggggct     1080

tgttaggagc tttgcgtgat tgttgtatcg ggaggcagta agaatcatct tttatcagta     1140

caagggacta gttaaaaatg gaaggttagg aaagactaag gtgcagggct taaaatggcg     1200

attttgacat tgcggcattg ctcagcatgg cgggctgtgc tttgttaggt tgtccaaaat     1260

ggcggatcca gttctgtcgc agtgttcaag tggcgggaag gccacatcat gatgggcgag     1320

gctttgttaa gtggttagca tggtggtgga catgtgcggt cacacaggaa aagatggcgg     1380

ctgaaggtct tgccgcagtg taaaacatgg cgggcctctt tgtctttgct gtgtgctttt     1440

cgtgttgggt tttgccgcag ggacaatatg gcaggcgttg tcatatgtat atcatggctt     1500

ttgtcacgtg gacatcatgg cgggcttgcc gcattgttaa agatggcggg ttttgccgcc     1560

tagtgccacg cagagcggga gaaaaggtgg gatggacagt gctggattgc tgcataaccc     1620

aaccaattag aaatgggggt ggaattgatc acagccaatt agagcagaag atggaattag     1680

actgatgaca cactgtccag ctactcagcg aagacctggg tgaattagca tggcacttcg     1740

cagctgtctt tagccagtca ggagaaagaa gtggaggggc cacgtgtatg tctcccagtg     1800

ggcggtacac caggtgtttt caaggtcttt tcaaggacat ttagcctttc cacctctgtc     1860

ccctcttatt tgtcccctcc tgtccagtgc tgcctcttgc agtgctggat atctggctgt     1920

gtggtctgaa cctccctcca ttcctctgta ttggtgcctc acctaaggct aagtatacct     1980

ccccccccac cccccaaccc ccccaactcc ccacccccac cccccacccc ccacctcccc     2040

acccccctac ccccctaccc ccctaccccc ctctggtctg ccctgcactg cactgttgcc     2100

atgggcagtg ctccaggcct gcttggtgtg gacatggtgg tgagccgtgg caaggaccag     2160

aatggatcac agatgatcgt tggccaacag gtggcagaag aggaattcct gccttcctca     2220

agaggaacac ctaccccttg gctaatgctg gggtcggatt ttgatttata tttatctttt     2280

ggatgtcagt catacagtct gattttgtgg tttgctagtg tttgaattta agtcttaagt     2340

gactattata gaaatgtatt aagaggcttt atttgtagaa ttcactttaa ttacatttaa     2400

tgagtttttg ttttgagttc cttaaaattc cttaaagttt ttagcttctc attacaaatt     2460

ccttaacctt tttttggcag tagatagtca aagtcaaatc atttctaatg ttttaaaaat     2520

gtgctggtca ttttctttga aattgactta actattttcc tttgaagagt ctgtagcaca     2580

gaaacagtaa aaaatttaac ttcatgacct aatgtaaaaa agagtgtttg aaggtttaca     2640

caggtccagg ccttgctttg ttcccatcct tgatgctgca ctaattgact aatcacctac     2700

ttatcagaca ggaaacttga attgctgtgg tctggtgtcc tctattcaga cttattatat     2760

tggagtattt caatttttcg ttgtatcctg cctgcctagc atccagttcc tccccagccc     2820

tgctcccagc aaacccctag tctagcccca gccctactcc caccccgccc cagccctgcc     2880

ccagccccag tcccctaacc ccccagccct agccccagtc ccagtcctag ttcctcagtc     2940

ccgcccagct tctctcgaaa gtcactctaa ttttcattga ttcagtgctc aaaataagtt     3000

gtccattgct tatcctatta tactgggata ttccgtttac ccttggcatt gctgatcttc     3060

agtactgact ccttgaccat tttcagttaa tgcatacaat cccatttgtc tgtgatctca     3120

ggacaaagaa tttccttact cggtacgttg aagttaggga atgtcaattg agagctttct     3180

atcagagcat tattgcccac aatttgagtt acttatcatt ttctcgatcc cctgccctta     3240

aaggagaaac catttctctg tcattgcttc tgtagtcaca gtcccaattt tgagtagtga     3300

tcttttcttg tgtactgtgt tggccaccta aaactctttg cattgagtaa aattctaatt     3360

gccaataatc ctacccattg gattagacag cactctgaac cccatttgca ttcagcaggg     3420

ggtcgcagac aacccgtctt ttgttggaca gttaaaatgc tcagtcccaa ttgtcatagc     3480

tttgcctatt aaacaaaggc accctactgc gctttttgct gtgcttctgg agaatcctgc     3540

tgttcttgga caattaaaga acaaagtagt aattgctaat tgtctcaccc attaatcatg     3600

aagactacca gtcgcccttg catttgcctt gaggcagcgc tgactacctg agatttaaga     3660

gtttcttaaa ttattgagta aaatcccaat tatccatagt tctgttagtt acactatggc     3720

ctttgcaaac atctttgcat aacagcagtg ggactgactc attcttagag ccccttccct     3780

tggaatatta atggatacaa tagtaattat tcatggttct gcgtaacaga gaagacccac     3840

ttatgtgtat gcctttatca ttgctcctag atagtgtgaa ctacctacca ccttgcatta     3900

atatgtaaaa cactaattgc ccatagtccc actcattagt ctaggatgtc ctctttgcca     3960

ttgctgctga gttctgacta cccaagtttc cttctcttaa acagttgata tgcataattg     4020

catatattca tggttctgtg caataaaaat ggattctcac cccatcccac cttctgtggg     4080

atgttgctaa cgagtgcaga ttattcaata acagctcttg aacagttaat ttgcacagtt     4140

gcaattgtcc agagtcctgt ccattagaaa gggactctgt atcctatttg cacgctacaa     4200

tgtgggctga tcacccaagg actcttcttg tgcattgatg ttcataattg tatttgtcca     4260

cgatcttgtg cactaaccct tccactccct ttgtattcca gcaggggacc cttactactc     4320

aagacctctg tactaggaca gtttatgtgc acaatcctaa ttgattagaa ctgagtcttt     4380

tatatcaagg tccctgcatc atctttgctt tacatcaaga gggtgctggt tacctaatgc     4440

ccctcctcca gaaattattg atgtgcaaaa tgcaatttcc ctatctgctg ttagtctggg     4500

gtctcatccc ctcatattcc ttttgtctta cagcaggggg tacttgggac tgttaatgcg     4560

cataattgca attatggtct tttccattaa attaagatcc caactgctca caccctctta     4620

gcattacagt agagggtgct aatcacaagg acatttcttt tgtactgtta atgtgctact     4680

tgcatttgtc cctcttcctg tgcactaaag accccactca cttccctagt gttcagcagt     4740

ggatgacctc tagtcaagac ctttgcacta ggatagttaa tgtgaaccat ggcaactgat     4800

cacaacaatg tctttcagat cagatccatt ttatcctcct tgttttacag caagggatat     4860

taattaccta tgttaccttt ccctgggact atgaatgtgc aaaattccaa tgttcatggt     4920

ctctcccttt aaacctatat tctacccctt ttacattata gaaagggatg ctggaaaccc     4980

agagtccttc tcttgggact cttaatgtgt atttctaatt atccatgact cttaatgtgc     5040

atattttcaa ttgcctaatt gatttcaatt gtctaagaca tttcaaatgt ctaattgatt     5100

agaactgagt cttttatatc aagctaatat ctagctttta tatcaagcta atatcttgac     5160

ttctcagcat catagaaggg ggtactgatt tcctaaagtc tttcttgaat ttctattatg     5220

caaaattgcc ctgaggccgg gtgtggtggc tcacacctgt aatcccagca ctttgggagg     5280

ctgaggtggg aagatccctt actgccagga gtttgagacc agcctggcca acattaaaaa     5340

aaaaaaaaag taagacaatt gccctggaat cccatccccc tcacacctcc ttggcaaagc     5400

agcaggagtg ctaactagct agtgcttctt ctcttatact gcttaaatgc gcataattag     5460

cagtagttga tgtgccccta tgttagagta gaatcccgct tccttgctcc atttgcatta     5520

ctgcaggagc ttctaactag cctgaattca ctctcttgga ctgttaatgt gcatacttat     5580

atttgctgct gtactttttt accatgtaag gaccccaccc actgtattta catcccagct     5640

ggaagtacct actacttaag acccttagac tagtaaagtt agcgtgcata atcttaggtg     5700

ttatatacac attttcagtt gcatacagtt gtgcctttta tcaggactcc tgtacttatc     5760

aaagcagaga gtgctaatca atattaagcc cttctcttcg aactgtagat ggcatgtaat     5820

tgcagttgtc aatggtcctt caattagact tgggtttctg acctatcaca ccctctttgc     5880

tttattgcat ggggtactat tcacttaagg cccctttctc aaactgttaa tgtgcctaat     5940

gacaattaca tcagtatcct tccttttgaa ggacagcatg gttggtgaca cctaaggccc     6000

catttcttgg cctcccaata tgtgtgattg tatttgtcga ggttgctatg cactagagaa     6060

ggaaagtgct cccctcatcc ccacttttcc cttccagcag gaagtgccca ccccataaga     6120

cccttttatt tggagagtct aggtgcacaa ttgtaagtga ccacaagcat gcatcttgga     6180

catttatgtg cgtaatcgca cactgctcat tccatgtgaa taaggtccta ctctccgacc     6240

ccttttgcaa tacagaaggg ttgctgataa cgcagtcccc ttttcttggc atgttgtgtg     6300

tgattataat cgtctgggat cctatgcact agaaaaggag ggtcctctcc acatacctca     6360

gtctcacctt tcccttccag cagggagtgc ccactccata agactctcac atttggacag     6420

tcaaggtgcg taattgttaa gtgaacacaa ccatgcacct tagacatgga tttgcataac     6480

tacacacagc tcaacctatc tgaataaaat cctactctca gacccctttt gcagtacagc     6540

aggggtgctg atcaccaagg ccctttttcc tggcctggta tgcgtgtgat tatgtttgtc     6600

ccggttcctg tgtattagac atggaagcct cccctgccac actccacccc caatcttcct     6660

ttcccttccg gcagggagtg ccctctccat aagacgctta cgtttggaca atcaaggtgc     6720

acagttgtaa gtgaccacag gcatacacct tggacattaa tgtgcataac cactttgccc     6780

attccatctg aataaggtcc tactctcaga ccccttttgc agtacagcag gggtgctgat     6840

caccaaggcc ccttttcttg gcctgttatg tgcgtgatta tatttgtctg ggttcctgtg     6900

tattagacaa ggaagccttc cccccgcccc cacccccact cccagtcttc ctttcccttc     6960

cagcagggag tgccccctcc ataagatcat tacatttgga caatcaaggt gcacaattat     7020

aagtgaccac agccatgcac cttggacatt attggacatt aatgtgcgta actgcacatg     7080

gcccatccca tctgaataag gtcctactct cagatgccct ttgcagtaca gcaggggtac     7140

tgaatcacca aggccctttt tcttggcctg ttatgtgtgt gattatattt atcccagttt     7200

ctgtgtaata gacatgaaag cctcccctgc cacaccccac ctccaatctt cctttccctt     7260

ccaccaggga gtgtccactc catataccct tacatttgga caatcaaggt gcacaattgt     7320

aagtgagcat aggcactcac cttggacatg aatgtgcata actgcacatg gcccatccca     7380

tctgaataag gtcctactct cagacccttt ttgcagtaca gcaggggtgc tgatcaccaa     7440

ggcccctttt cctggcctgt tatgtgtgtg attatatttg ttccagttcc tgtgtaatag     7500

acatggaagc ctcccctgcc acactccacc cccaatcttc ctttcccttc tggcaggaag     7560

tacccgctcc ataagaccct tacatttgga cagtcaaggt gcacaattgt atgtgaccac     7620

aaccatgcac cttggacata aatgtgtgta actgcacatg gcccatccca tctgaataag     7680

gtcctactct cagacccctt ttgcagtaca gtaggtgtgc tgataaccaa ggcccctctt     7740

cctggcctgt taacgtatgt gattatattt gtctgggttc cagtgtataa gacatggaag     7800

cctcccctgc cccaccccac cctcaatctt cctttccctt ctggcaggga gtgccagctc     7860

cataagaacc ttacatttgg acagtcaagg tgcacaattc taagtgaccg cagccatgca     7920

ccttggtcaa taatgtgtgt aactgcacac ggcctatctc atctgaataa ggccttactc     7980

tcagacccct tttgcagtac agcaggggtg ctgataacca aggcccattt tcctggcctg     8040

ttatgtgtgt gattatattt gtccaggttt ctgtgtacta gacaaggaag cctcctctgc     8100

cccatcccat ctacgcataa tctttctttt cctcccagca gggagtgctc actccataag     8160

acccttacat ttggacaatc aaggtgcaca attgtaagtg accacaacca tgcatcttgg     8220

aaatttatgt gcataactgc acatggctta tcctatttga ataaagtcct actctcagac     8280

cccctttgca gtatagctgg ggtgctgatc actgaggcct ctttgcttgg cttgtctata     8340

ttcttgtgta ctagataagg gcaccttctc atggactccc tttgcttttc aacaaggagt     8400

acccactact ttttaagatt cttatatttg tccaaagtac atggttttaa ttgaccacaa     8460

caatgtccct tggacattaa tgtatgtaat caccacatgg ttcatcctaa ttaaacaaag     8520

ttctaccttc tcaccctcca tttgcagtat accagggttg ctgaccccct aagtcccctt     8580

ttcttggctt gttgacatgc ataattgcat ttatgttggt tcttgtgccc tagacaagga     8640

tgccccacct cttttcaata gtgggtgccc actccttatg atctttacat ttgaacagtt     8700

aatgtgaata attgcagttg tccacaaccc tatcacttct aggaccatta tacctctttt     8760

gcattactgt ggggtatact gtttccctcc aaggcccctt ctggtggact atcaacatat     8820

aattgaaatt ttcttttgtc tttgtcagta gattaaggtc ataccccatc acctttcctt     8880

tgtagtacaa cagggtgtcc tgatcaacca aagtcctgtt gttttggact gttaatatgt     8940

gcaattacat ttgctcctga tctgtgcact agataaggat cctacctact ttcttagtgt     9000

ttttagcagg tagtgcccac tactcaagac tgtcacttgg aatgttcatg tgcacaaact     9060

caattctcta agcatgttcc tgtaccacct ttgctttaga gcagggggat gatattcact     9120

aagtgcccct tcttttggac ttaatatgca ttaatgcaat tgtccacctc ttcttttaga     9180

ctaagagttg atctccacat attccccttg catcaggggc atgttaatta tgaatgaacc     9240

cttttctttt aatattaatg tcataattgt atttgtggac ctgtgtagga gaaaaagacc     9300

ctatgttcct cccattaccc tttggattgc tgctgagaag tgttaactac tcataatctc     9360

agctcttgga caattaatag cattaataac aattatcaag ggcactgatc attagataag     9420

actcctgctt cctcgttgct tacatcgggg gtactgaccc actaaggccc cttgtactgt     9480

taatgtgaat atttgcaatt atatatgtct ccttctggta gagtgggata ttatgcccta     9540

gtatcccctt tgcattactg caggggctgc tgactactca aaacttctcc tgggactgtt     9600

aataggcaca atggcagtta tcaatggttt tctccctccc tgaccttgtt aagcaagcgc     9660

cccaccccac ccttagtttc ccatggcata ataaagtata agcattggag tattccatgc     9720

acttgtctat caaacagtgg tccatactcc caaccctttt gcattgcgcc agtgtgtaaa     9780

atcacaggta gccatggtgt catgctttat atacgaagtc ttccctctct ctgccccttg     9840

tgtgcccttg gccccttttt acagactatt gctcacaatc tcaggtgtcc atatttgcag     9900

ctattaggta agattgtgct gtctccctct tcccttccct ctgccctgcc ccttttgcct     9960

ctttgctggg taatgttgac cagacaaggc cctttctctt ggacttaaac aattctcagt    10020

tgcactttcc ttggtcccac ccattataca tgaacccctc tacttccttt cgcattgctt    10080

ctgagtatgc tgactaccca aagccccttc tgtgttatta ataaacacag tactgattgt    10140

cccatttttc agcccatcag tccaagatct ccctaccact ttggtgtgtt ggtgcagtgt    10200

tgactatgaa aagcaggcct gaactaggtg gataagcctt cactcatttt ctttcattta    10260

ttaatgatcc tagtttcaat tattgtcaga ttctggggac aagaaccatt cttgcccacc    10320

tgtgttactg ctttactgtg caaaatactg aaggcaagtc agacccaggg agctggattg    10380

ccatccttta ttttgtgttt ccagtgtaca ctataaaatt gtctccccag gaaggaaggt    10440

tggcactttc tctgcattct tctttccaga gcagattgcc tggttaagaa tctcttgttg    10500

tcccctttgt atattgttat tgtaaagtgc caaatgccag gatacagcca gaaaaattgc    10560

ttattattat taaaaaaatt tttttaagaa agacatctgg attgtagggt ggactcgata    10620

acctggtcat tatttttttg aagccaaaat atccatttat actatgtacc tggtgaccag    10680

tgtctctcat tttaactgag ggtggtgggt ctgtggatag aacactgact cttgctattt    10740

taatatcaaa gatattctag agtggaactc ttaagaccag tatctttgtg tgggctttac    10800

cagcattcac ttttagaaaa actacctaaa ttttataatc ctttaatttc ttcatctgga    10860

gcacctgccc ctacttattt caagaagatt gcagtaaaac gattaaatga gggaacatat    10920

gcagaggtgc ttttaaaaag catatgccac cttttttatt aattattata taaaatgaag    10980

catttaatta tagtaataat ttgaagtagt ttgaagtacc acactgaggt gaggacttaa    11040

aaatgataag acgagttccc tattttataa gaaaaataag ccaaaattaa atattctttt    11100

ggatataaat ttcaacagtg agatagctgc ctagtggaaa tgaataatat cccagccact    11160

agtgtacagg gtgttttgtg gcacaggatt atgtaatatg gaactgctca agcaaataac    11220

tagtcatcac aacagcagtt ctttgtaata actgaaaaag aatattgttt ctcggagaag    11280

gatgtcaaaa gatcggccca gctcagggag cagtttgccc tactagctcc tcggacagct    11340

gtaaagaaga gtctctggct ctttagaata ctgatcccat tgaagatacc acgctgcatg    11400

tgtccttagt agtcatgtct ccttaggctc ctcttggaca ttctgagcat gtgagacctg    11460

aggactgcaa acagctataa gaggctccaa attaatcata tctttccctt tgagaatctg    11520

gccaagctcc agctaatcta cttggatggg ttgccagcta tctggagaaa aagatcttcc    11580

tcagaagaat aggcttgttg ttttacagtg ttagtgatcc attccctttg acgatcccta    11640

ggtggagatg gggcatgagg atcctccagg ggaaaagctc actaccactg ggcaacaacc    11700

ctaggtcagg aggttctgtc aagatacttt cctggtccca gataggaaga taaagtctca    11760

aaaacaacca ccacacgtca agctcttcat tgttcctatc tgccaaatca ttatacttcc    11820

tacaagcagt gcagagagct gagtcttcag caggtccaag aaatttgaac acactgaagg    11880

aagtcagcct tcccacctga agatcaacat gcctggcact ctagcacttg aggatagctg    11940

aatgaatgtg tatttctttg tctctttctt tcttgtcttt gctctttgtt ctctatctaa    12000

agtgtgtctt acccatttcc atgtttctct tgctaatttc tttcgtgtgt gcctttgcct    12060

cattttctct ttttgttcac aagagtggtc tgtgtcttgt cttagacata tctctcattt    12120

ttcattttgt tgctatttct ctttgctctc ctagatgtgg ctcttctttc acgctttatt    12180

tcatgtctcc tttttgggtc acatgctgtg tgctttttgt ccttttcttg ttctgtctac    12240

ctctcctttc tctgcctacc tctcttttct ctttgtgaac tgtgattatt tgttacccct    12300

tccccttctc gttcgtttta aatttcacct tttttctgag tctggcctcc tttctgctgt    12360

ttctactttt tatctcacat ttctcatttc tgcatttcct ttctgcctct cttgggctat    12420

tctctctctc ctcccctgcg tgcctcagca tctcttgctg tttgtgattt tctatttcag    12480

tattaatctc tgttggcttg tatttgttct ctgcttcttc cctttctact cacctttgag    12540

tatttcagcc tcttcatgaa tctatctccc tctctttgat ttcatgtaat ctctccttaa    12600

atatttcttt gcatatgtgg gcaagtgtac gtgtgtgtgt gtcatgtgtg gcagaggggc    12660

ttcctaaccc ctgcctgata ggtgcagaac gtcggctatc agagcaagca ttgtggagcg    12720

gttccttatg ccaggctgcc atgtgagatg atccaagacc aaaacaaggc cctagactgc    12780

agtaaaaccc agaactcaag tagggcagaa ggtggaaggc tcatatggat agaaggccca    12840

aagtataaga cagatggttt gagacttgag acccgaggac taagatggaa agcccatgtt    12900

ccaagataga tagaagcctc aggcctgaaa ccaacaaaag cctcaagagc caagaaaaca    12960

gagggtggcc tgaattggac cgaaggcctg agttggatgg aagtctcaag gcttgagtta    13020

gaagtcttaa gacctgggac aggacacatg gaaggcctaa gaactgagac ttgtgacaca    13080

aggccaacga cctaagatta gcccagggtt gtagctggaa gacctacaac ccaaggatgg    13140

aaggcccctg tcacaaagcc tacctagatg gatagaggac ccaagcgaaa aaggtatctc    13200

aagactaacg gccggaatct ggaggcccat gacccagaac ccaggaagga tagaagcttg    13260

aagacctggg gaaatcccaa gatgagaacc ctaaacccta cctcttttct attgtttaca    13320

cttcttactc ttagatattt ccagttctcc tgtttatctt taagcctgat tcttttgaga    13380

tgtacttttt gatgttgccg gttaccttta gattgacagt attatgcctg ggccagtctt    13440

gagccagctt taaatcacag cttttaccta tttgttaggc tatagtgttt tgtaaacttc    13500

tgtttctatt cacatcttct ccacttgaga gagacaccaa aatccagtca gtatctaatc    13560

tggcttttgt taacttccct caggagcaga cattcatata ggtgatactg tatttcagtc    13620

ctttcttttg accccagaag ccctagactg agaagataaa atggtcaggt tgttggggaa    13680

aaaaaagtgc caggctctct agagaaaaat gtgaagagat gctccaggcc aatgagaaga    13740

attagacaag aaatacacag atgtgccaga cttctgagaa gcacctgcca gcaacagctt    13800

ccttctttga gcttaggtga gcaggattct ggggtttggg atttctagtg atggttatgg    13860

aaagggtgac tgtgcctggg acaaagcgag gtcccaaggg gacagcctga actccctgct    13920

catagtagtg gccaaataat ttggtggact gtgccaacgc tactcctggg tttaataccc    13980

atctctaggc ttaaagatga gagaacctgg gactgttgag catgtttaat actttccttg    14040

atttttttct tcctgtttat gtgggaagtt gatttaaatg actgataatg tgtatgaaag    14100

cactgtaaaa cataagagaa aaaccaatta gtgtattggc aatcatgcag ttaacatttg    14160

aaagtgcagt gtaaattgtg aagcattatg taaatcaggg gtccacagtt tttctgtaag    14220

gggtcaaatc ataaatactt tagactgtgg gccatatggt ttctgttaca tatttgtttt    14280

ttaaacaacg tttttataag gtcaaaatca ttcttagttt ttgagccaat tggatttggc    14340

ctgctgttca tagcttacca ccccctgatg tattatttgt tattcagaga aaatttctga    14400

atactactag tttccttttc tgtgcctgtc cctgtgctag gcactaaaaa tgcaatgatt    14460

attgatatct aggtgacctg aaaaaaaata gtgaatgtgc tttgtaaact gtaaagcact    14520

tgtattctac tgtgataagc gttgtggata caaagaaagg agcaagcata aaaaagtgct    14580

ctttcaaaag gatatagtac tatgcagaca caaggaattg tttgataaat gaataaatta    14640

tatgtatatt tgaggccaat ttgtgtttgc tgctctggta attttgagta aaaatgcagt    14700

attccaggta tcagaaacga aaacacatgg aaactgcttt taaactttaa aatatactga    14760

aaacataagg gactaagctt gttgtggtca cctataatgt gccagatacc atgctgggtg    14820

ctagagctac caaaggggga aaagtattct catagaacaa aaaatttcag aaaggtgcat    14880

attaaagtgc tttgtaaact aaagcatgat acaaatgtca atgggctaca tatttatgaa    14940

tgaatgaatg gatgaatgaa tattaagtgc ctcttacata ccagctattt tgggtactgt    15000

aaaatacaag attaattctc ctatgtaata agaggaaagt ttatcctcta tactattcag    15060

atgtaaggaa tgatatattg cttaatttta aacaatcaag actttactgg tgaggttaag    15120

ttaaattatt actgatacat ttttccaggt aaccaggaaa gagctagtat gaggaaatga    15180

agtaatagat gtgagatcca gaccgaaagt cacttaattc agcttgcgaa tgtgctttct    15240

aaattataaa gcacttgtaa atgaaaaatt tgatgctttc tgtatgaata aaactttctg    15300

taagctaggt attgtctcta caaaattctc attgtatagt taaaccacag tgagaagggt    15360

tctataagta gttatacaaa ccaagggttt aaatacctgt taaatagatc aattttgatt    15420

gcctactatg tgaactcact gttaaaggca ctgaaaattt atcatatttc atttagccac    15480

agccaaaaat aaggcaatac ctatgttagc attttgtgaa ctctaaggca ccatataaat    15540

gtaactgttg attttctcac ttggtgctgg gtactaggtt tataaaattg tatgatagtt    15600

attatattgt gcaaataaag taggaaaatt tgaataacaa tgattatctt ttgaatacgc    15660

atacgcaagg gattggttgt ctgaagaatg ccactatagt agttatctat tgtgtgccaa    15720

tctcattgct aggcattggg gatgcaaaga taaaccatct ttattgtgtc ttgggtagca    15780

gaagaaaata tgtgtaaaat caatttataa tttgtaaact gccacccata tataagctat    15840

atctgctgaa tgatcattga ttactcttat ccttagagat aacaactggg ggcacaaaca    15900

tttattatca ttattgaacc tacaacagag atctatgtgt agatttacaa agcctacagt    15960

tctatacaga taggaatgaa ctattggctt actgaatggt gattactttc tgtggggctc    16020

ggaactacat gccctaggat ataaaaatga tgttatcatt atagagtgct cacagaagga    16080

aatgaagtaa tataggtgtg agatccagac caaaagtcat ttaacaagtt tattcagtga    16140

tgaaaacatg ggacaaatgg actaatataa ggcagtgtac taagctgagt agagagataa    16200

agtcctgtcc agaagataca tgcttcctgg cctgattgag gagatggaaa atttttgcaa    16260

aaaacaaggt gttgtggtct tccatccagt ttcttaagtg ctgatgataa aagtgaatta    16320

gacccacctt gacctggcct acagaagtaa aggagtaaaa ataaatgcct caggcgtgct    16380

ttttgattca tttgataaac aaagcatctt ttatgtggaa tataccattc tgggtcctga    16440

ggataagaga gatgagggca ttagatcact gacagctgaa gatagaagaa catctttggt    16500

ttgattgttt aaataatatt tcaatgccta ttctctgcaa ggtactatgt ttcgtaaatt    16560

aaataggtct ggcccagaag acccactcaa ttgcctttga gattaaaaaa aaaaaaaaaa    16620

agaaagaaaa atgcaagttt ctttcaaaat aaagagacat ttttcctagt ttcaggaatc    16680

ccccaaatca cttcctcatt ggcttagttt aaagccagga gactgataaa agggctcagg    16740

gtttgttctt taattcatta actaaacatt ctgcttttat tacagttaaa tggttcaaga    16800

tgtaacaact agttttaaag gtatttgctc attggtctgg cttagagaca ggaagacata    16860

tgagcaataa aaaaaagatt cttttgcatt taccaattta gtaaaaattt attaaaactg    16920

aataaagtgc tgttcttaag tgcttgaaag acgtaaacca aagtgcactt tatctcattt    16980

atcttatggt ggaaacacag gaacaaattc tctaagagac tgtgtttctt tagttgagaa    17040

gaaacttcat tgagtagctg tgatatgttc gatactaagg aaaaactaaa cagatcacct    17100

ttgacatgcg ttgtagagtg ggaataagag agggcttttt attttttcgt tcatacgagt    17160

attgatgaag atgatactaa atgctaaatg aaatatatct gctccaaaag gcatttattc    17220

tgacttggag atgcaacaaa aacacaaaaa tggaatgaag tgatactctt catcaaacag    17280

aagtgactgt tatctcaacc attttgttaa atcctaaaca gaaaacaaaa aaaatcatga    17340

cgaaaagaca cttgcttatt aattggcttg gaaagtagaa tataggagaa aggttactgt    17400

ttattttttt tcatgtattc attcattcta caaatatatt cgggtgccaa taggtacttg    17460

gtataaggtt tttggcccca gagacatggg aaaaaaatgc atgccttccc agagaatgcc    17520

taatactttc cttttggctt gttttcttgt taggggcatg gcttagtccc taaataacat    17580

tgtgtggttt aattcctact ccgtatctct tctaccactc tggccactac gataagcagg    17640

tagctgggtt ttgtagtgag cttgctcctt aagttacagg aactctcctt ataatagaca    17700

cttcattttc ctagtccatc cctcatgaaa aatgactgac cactgctggg cagcaggagg    17760

gatgatgacc aactaattcc caaaccccag tctcattggt accagccttg gggaaccacc    17820

tacacttgag ccacaattgg ttttgaagtg catttacaag gtttgtctat tttcagttct    17880

ttacttttta catgctgaca catacataca ctgcctaaat agatctcttt cagaaacaat    17940

cctcagataa cgcatagcaa aatggagatg gagacatgat ttctcatgca acagcttctc    18000

taattatacc ttagaaatgt tctccttttt atcatcaaat ctgctcaaga agggcttttt    18060

atagtagaat aatatcagtg gatgaaaaca gcttaacatt ttaccatgct taagttttaa    18120

gaataaaata aaaattggaa ataattggcc aaaattgaaa ggaaaaattt ttttaaaatt    18180

tctctaaatg taggcctggc tgggctttga ccttttccgt ttttaaatca ctcacagagg    18240

gtgggacagg aggaagagtg aaggaaaagg tcaaacctgt tttaagggca acctgccttt    18300

gttctgaatt ggtcttaaga acattaccag ctccaggttt aaattgttca gtttcatgca    18360

gttccaatag ctgatcattg ttgagatgag gacaaaatcc tttgtcctca ctagtttgct    18420

ttacattttt gaaaagtatt atttttgtcc aagtgcttat caactaaacc ttgtgttagg    18480

taagaatgga atttattaag tgaatcagtg tgacccttct tgtcataaga ttatcttaaa    18540

gctgaagcca aaatatgctt caaaagaaga ggactttatt gttcattgta gttcatacat    18600

tcaaagcatc tgaactgtag tttctatagc aagccaatta catccataag tggagaagga    18660

aatagataaa tgtcaaagta tgattggtgg agggagcaag gttgaagata atctggggtt    18720

gaaattttct agttttcatt ctgtacattt ttagttagac atcagatttg aaatattaat    18780

gtttaccttt caatgtgtgg tatcagctgg actcagtaac acccctttct tcagctgggg    18840

atggggaatg gattattgga aaatggaaag aagaaagtaa ctaaaagcct tcctttcaca    18900

gtttctggca tcactaccac tactgattaa acaagaataa gagaacattt tatcatcatc    18960

tgctttattc acataaatga agttgtgatg aataaatctg cttttatgca gacacaagga    19020

attaagtggc ttcgtcattg tccttctacc tcaaagataa tttattccaa aagctaagat    19080

aaatggaaga ctcttgaact tgtgaactga tgtgaaatgc agaatctctt ttgagtcttt    19140

gctgtttgga agattgaaaa atattgttca gcatgggtga ccaccagaaa gtaatcttaa    19200

gccatctaga tgtcacaatt gaaacaaact ggggagttgg ttgctattgt aaaataaaat    19260

atactgtttt gaaaactttg aaaaaaaaaa aaaaaa                              19296


<210>  38
<211>  203
<212>  DNA
<213>  homo sapiens

<400>  38
gggtaaattt tgaaccaacc aaatcacaaa gatgtccggc tttcaatctt ctaggccacg       60

cctcttatgc tctctccgcc ctcagccccc ccttcagttc ttaaagcgct gcaattcgct      120

gctgcagcca tatttcttac tctctcgggg ctggaagctt cctgactgaa gatctgttct      180

agaaagaacc ccaagtgcag aga                                              203


