               SEQUENCE LISTING

<110> Blue Sky Vaccines GmbH

<120> HIGH GROWTH INFLUENZA VIRUS

<130> MT005P

<160> 38

<170> BiSSAP 1.3

<210> 1
<211> 2396
<212> DNA
<213> Influenza B virus

<400> 1
agcagaagcg gagcgttttc aagatgacat tggctaaaat tgaattgtta aaacaactgt      60

taagggacaa tgaagccaaa acagtactga aacaaacaac agtagatcaa tataacataa     120

taagaaaatt caatacatca agaattgaaa agaacccttc attaaggatg aagtgggcga     180

tgtgttctaa ttttcccttg gctttgacca agggtgacat ggcaaacaga atccccttgg     240

aatacaaggg aatacaactt aaaacaaatg ctgaagacat aggaaccaaa ggccaaatgt     300

gctcaatagc agcagttacc tggtggaata catatggacc aataggggat actgaaggtt     360

tcgaaaaagt ctacgaaagc ttttttctca gaaagatgag acttgacaat gccacttggg     420

gccgaataac ttttggccca gttgaaagag taagaaaaag ggtactgcta aaccctctca     480

ccaaggaaat gcctccagat gaagcaagta atgtgataat ggaaatattg ttccctaaag     540

aagcaggaat accaagagaa tctacttgga tacataggga actgataaaa gaaaaaagag     600

aaaaattgaa aggaacgatg ataactccca ttgtactggc atacatgctc gagagggaat     660

tagttgccag gagaaggttc ctgcccgtgg caggagcaac atcagctgag ttcatagaaa     720

tgctacactg cttacaaggt gaaaattgga ggcaaatata tcacccggga gggaataaac     780

taactgaatc taggtcccaa tcgatgattg tggcttgtag aaagataatc agaagatcaa     840

tagtcgcatc aaacccattg gagctagctg tagaaattgc aaataagact gtgatagata     900

ctgaaccttt aaaatcatgt ctgacagcca tagacggagg tgatgtcgcc tgtgacataa     960

taagagctgc attaggacta aagatcagac aaagacaaag atttggacga cttgaactaa    1020

agagaatatc aggaagagga ttcaaaaatg atgaagaaat attaatcggg aacggaacaa    1080

tacagaagat tggaatatgg gacggagaag aggagttcca tgtgagatgt ggtgaatgca    1140

ggggaatatt aaaaaagagc aaaatgagaa tggaaaaact actaataaat tcagctaaaa    1200

aggaggacat gaaagattta ataatcttgt gcatggtatt ttcccaagac actaggatgt    1260

tccaaggagt gaggggtgaa ataaattttc ttaatagagc aggccaactt ttatctccaa    1320

tgtatcaact ccaaagatat tttttgagta gaagtaacga tctctttgat caatgggggt    1380

atgaggaatc acccaaagca agtgagctac atgggataaa tgaactaatg aatgcatctg    1440

actacacttt gaaaggggtt gtagtaacaa aaaatgtgat tgatgatttt agttctactg    1500

aaacagaaaa agtatctata acaaaaaatc ttagtttaat aaaaaggact ggggaagtca    1560

taatgggagc caatgacgta agtgaattag aatcacaagc acagctaatg ataacatatg    1620

atacaccaaa gatgtgggag atggggacaa ccaaagaact ggtgcaaaac acctatcaat    1680

gggtgctgaa aaatttggta acactgaagg ctcagtttct tctagggaaa gaagacatgt    1740

tccaatggga tgcatttgaa gcatttgaaa gcataatccc ccagaagatg gctggccaat    1800

acagtggatt tgcaagagca gtgctcaaac aaatgagaga ccaagaggtc atgaaaactg    1860

accagttcat aaagttgttg cccttttgtt tctcaccacc aaagttaagg agcaatgggg    1920

agccttatca gttcttgagg cttgtattga agggaggagg agaaaatttc atcgaagtaa    1980

ggaaagggtc tcctctattc tcttacaatc cacaaacaga agtcctaact atatgcggca    2040

gaatgatgtc attaaaaggg aaaattgaag atgaagaaag gaatagatca atggggaatg    2100

cagtgttggc gggttttctt gttagtggca agtatgaccc agatcttgga gatttcaaaa    2160

ccattgaaga acttgaaaag ctaaaaccag gggagaaagc aaacatctta ctttatcaag    2220

gaaagcccgt taaagtagtt aaaaggaaaa gatatagtgc tttatccaat gacatttcac    2280

aaggaattaa gagacaaaga atgacagttg agtccatggg gtgggccttg agctaatata    2340

aatttatcca ttaattcaat gaatacaatt gagtgaaaaa tgctcgtgtt tctact        2396


<210> 2
<211> 770
<212> PRT
<213> Influenza B virus

<400> 2
Met Thr Leu Ala Lys Ile Glu Leu Leu Lys Gln Leu Leu Arg Asp Asn 
1               5                   10                  15      
Glu Ala Lys Thr Val Leu Lys Gln Thr Thr Val Asp Gln Tyr Asn Ile 
            20                  25                  30          
Ile Arg Lys Phe Asn Thr Ser Arg Ile Glu Lys Asn Pro Ser Leu Arg 
        35                  40                  45              
Met Lys Trp Ala Met Cys Ser Asn Phe Pro Leu Ala Leu Thr Lys Gly 
    50                  55                  60                  
Asp Met Ala Asn Arg Ile Pro Leu Glu Tyr Lys Gly Ile Gln Leu Lys 
65                  70                  75                  80  
Thr Asn Ala Glu Asp Ile Gly Thr Lys Gly Gln Met Cys Ser Ile Ala 
                85                  90                  95      
Ala Val Thr Trp Trp Asn Thr Tyr Gly Pro Ile Gly Asp Thr Glu Gly 
            100                 105                 110         
Phe Glu Lys Val Tyr Glu Ser Phe Phe Leu Arg Lys Met Arg Leu Asp 
        115                 120                 125             
Asn Ala Thr Trp Gly Arg Ile Thr Phe Gly Pro Val Glu Arg Val Arg 
    130                 135                 140                 
Lys Arg Val Leu Leu Asn Pro Leu Thr Lys Glu Met Pro Pro Asp Glu 
145                 150                 155                 160 
Ala Ser Asn Val Ile Met Glu Ile Leu Phe Pro Lys Glu Ala Gly Ile 
                165                 170                 175     
Pro Arg Glu Ser Thr Trp Ile His Arg Glu Leu Ile Lys Glu Lys Arg 
            180                 185                 190         
Glu Lys Leu Lys Gly Thr Met Ile Thr Pro Ile Val Leu Ala Tyr Met 
        195                 200                 205             
Leu Glu Arg Glu Leu Val Ala Arg Arg Arg Phe Leu Pro Val Ala Gly 
    210                 215                 220                 
Ala Thr Ser Ala Glu Phe Ile Glu Met Leu His Cys Leu Gln Gly Glu 
225                 230                 235                 240 
Asn Trp Arg Gln Ile Tyr His Pro Gly Gly Asn Lys Leu Thr Glu Ser 
                245                 250                 255     
Arg Ser Gln Ser Met Ile Val Ala Cys Arg Lys Ile Ile Arg Arg Ser 
            260                 265                 270         
Ile Val Ala Ser Asn Pro Leu Glu Leu Ala Val Glu Ile Ala Asn Lys 
        275                 280                 285             
Thr Val Ile Asp Thr Glu Pro Leu Lys Ser Cys Leu Thr Ala Ile Asp 
    290                 295                 300                 
Gly Gly Asp Val Ala Cys Asp Ile Ile Arg Ala Ala Leu Gly Leu Lys 
305                 310                 315                 320 
Ile Arg Gln Arg Gln Arg Phe Gly Arg Leu Glu Leu Lys Arg Ile Ser 
                325                 330                 335     
Gly Arg Gly Phe Lys Asn Asp Glu Glu Ile Leu Ile Gly Asn Gly Thr 
            340                 345                 350         
Ile Gln Lys Ile Gly Ile Trp Asp Gly Glu Glu Glu Phe His Val Arg 
        355                 360                 365             
Cys Gly Glu Cys Arg Gly Ile Leu Lys Lys Ser Lys Met Arg Met Glu 
    370                 375                 380                 
Lys Leu Leu Ile Asn Ser Ala Lys Lys Glu Asp Met Lys Asp Leu Ile 
385                 390                 395                 400 
Ile Leu Cys Met Val Phe Ser Gln Asp Thr Arg Met Phe Gln Gly Val 
                405                 410                 415     
Arg Gly Glu Ile Asn Phe Leu Asn Arg Ala Gly Gln Leu Leu Ser Pro 
            420                 425                 430         
Met Tyr Gln Leu Gln Arg Tyr Phe Leu Ser Arg Ser Asn Asp Leu Phe 
        435                 440                 445             
Asp Gln Trp Gly Tyr Glu Glu Ser Pro Lys Ala Ser Glu Leu His Gly 
    450                 455                 460                 
Ile Asn Glu Leu Met Asn Ala Ser Asp Tyr Thr Leu Lys Gly Val Val 
465                 470                 475                 480 
Val Thr Lys Asn Val Ile Asp Asp Phe Ser Ser Thr Glu Thr Glu Lys 
                485                 490                 495     
Val Ser Ile Thr Lys Asn Leu Ser Leu Ile Lys Arg Thr Gly Glu Val 
            500                 505                 510         
Ile Met Gly Ala Asn Asp Val Ser Glu Leu Glu Ser Gln Ala Gln Leu 
        515                 520                 525             
Met Ile Thr Tyr Asp Thr Pro Lys Met Trp Glu Met Gly Thr Thr Lys 
    530                 535                 540                 
Glu Leu Val Gln Asn Thr Tyr Gln Trp Val Leu Lys Asn Leu Val Thr 
545                 550                 555                 560 
Leu Lys Ala Gln Phe Leu Leu Gly Lys Glu Asp Met Phe Gln Trp Asp 
                565                 570                 575     
Ala Phe Glu Ala Phe Glu Ser Ile Ile Pro Gln Lys Met Ala Gly Gln 
            580                 585                 590         
Tyr Ser Gly Phe Ala Arg Ala Val Leu Lys Gln Met Arg Asp Gln Glu 
        595                 600                 605             
Val Met Lys Thr Asp Gln Phe Ile Lys Leu Leu Pro Phe Cys Phe Ser 
    610                 615                 620                 
Pro Pro Lys Leu Arg Ser Asn Gly Glu Pro Tyr Gln Phe Leu Arg Leu 
625                 630                 635                 640 
Val Leu Lys Gly Gly Gly Glu Asn Phe Ile Glu Val Arg Lys Gly Ser 
                645                 650                 655     
Pro Leu Phe Ser Tyr Asn Pro Gln Thr Glu Val Leu Thr Ile Cys Gly 
            660                 665                 670         
Arg Met Met Ser Leu Lys Gly Lys Ile Glu Asp Glu Glu Arg Asn Arg 
        675                 680                 685             
Ser Met Gly Asn Ala Val Leu Ala Gly Phe Leu Val Ser Gly Lys Tyr 
    690                 695                 700                 
Asp Pro Asp Leu Gly Asp Phe Lys Thr Ile Glu Glu Leu Glu Lys Leu 
705                 710                 715                 720 
Lys Pro Gly Glu Lys Ala Asn Ile Leu Leu Tyr Gln Gly Lys Pro Val 
                725                 730                 735     
Lys Val Val Lys Arg Lys Arg Tyr Ser Ala Leu Ser Asn Asp Ile Ser 
            740                 745                 750         
Gln Gly Ile Lys Arg Gln Arg Met Thr Val Glu Ser Met Gly Trp Ala 
        755                 760                 765             
Leu Ser 
    770 

<210> 3
<211> 2396
<212> DNA
<213> Artificial Sequence

<220> 
<223> PB2 G427S

<400> 3
agcagaagcg gagcgttttc aagatgacat tggctaaaat tgaattgtta aaacaactgt      60

taagggacaa tgaagccaaa acagtactga aacaaacaac agtagatcaa tataacataa     120

taagaaaatt caatacatca agaattgaaa agaacccttc attaaggatg aagtgggcga     180

tgtgttctaa ttttcccttg gctttgacca agggtgacat ggcaaacaga atccccttgg     240

aatacaaggg aatacaactt aaaacaaatg ctgaagacat aggaaccaaa ggccaaatgt     300

gctcaatagc agcagttacc tggtggaata catatggacc aataggggat actgaaggtt     360

tcgaaaaagt ctacgaaagc ttttttctca gaaagatgag acttgacaat gccacttggg     420

gccgaataac ttttggccca gttgaaagag taagaaaaag ggtactgcta aaccctctca     480

ccaaggaaat gcctccagat gaagcaagta atgtgataat ggaaatattg ttccctaaag     540

aagcaggaat accaagagaa tctacttgga tacataggga actgataaaa gaaaaaagag     600

aaaaattgaa aggaacgatg ataactccca ttgtactggc atacatgctc gagagggaat     660

tagttgccag gagaaggttc ctgcccgtgg caggagcaac atcagctgag ttcatagaaa     720

tgctacactg cttacaaggt gaaaattgga ggcaaatata tcacccggga gggaataaac     780

taactgaatc taggtcccaa tcgatgattg tggcttgtag aaagataatc agaagatcaa     840

tagtcgcatc aaacccattg gagctagctg tagaaattgc aaataagact gtgatagata     900

ctgaaccttt aaaatcatgt ctgacagcca tagacggagg tgatgtcgcc tgtgacataa     960

taagagctgc attaggacta aagatcagac aaagacaaag atttggacga cttgaactaa    1020

agagaatatc aggaagagga ttcaaaaatg atgaagaaat attaatcggg aacggaacaa    1080

tacagaagat tggaatatgg gacggagaag aggagttcca tgtgagatgt ggtgaatgca    1140

ggggaatatt aaaaaagagc aaaatgagaa tggaaaaact actaataaat tcagctaaaa    1200

aggaggacat gaaagattta ataatcttgt gcatggtatt ttcccaagac actaggatgt    1260

tccaaggagt gaggggtgaa ataaattttc ttaatagagc aagccaactt ttatctccaa    1320

tgtatcaact ccaaagatat tttttgagta gaagtaacga tctctttgat caatgggggt    1380

atgaggaatc acccaaagca agtgagctac atgggataaa tgaactaatg aatgcatctg    1440

actacacttt gaaaggggtt gtagtaacaa aaaatgtgat tgatgatttt agttctactg    1500

aaacagaaaa agtatctata acaaaaaatc ttagtttaat aaaaaggact ggggaagtca    1560

taatgggagc caatgacgta agtgaattag aatcacaagc acagctaatg ataacatatg    1620

atacaccaaa gatgtgggag atggggacaa ccaaagaact ggtgcaaaac acctatcaat    1680

gggtgctgaa aaatttggta acactgaagg ctcagtttct tctagggaaa gaagacatgt    1740

tccaatggga tgcatttgaa gcatttgaaa gcataatccc ccagaagatg gctggccaat    1800

acagtggatt tgcaagagca gtgctcaaac aaatgagaga ccaagaggtc atgaaaactg    1860

accagttcat aaagttgttg cccttttgtt tctcaccacc aaagttaagg agcaatgggg    1920

agccttatca gttcttgagg cttgtattga agggaggagg agaaaatttc atcgaagtaa    1980

ggaaagggtc tcctctattc tcttacaatc cacaaacaga agtcctaact atatgcggca    2040

gaatgatgtc attaaaaggg aaaattgaag atgaagaaag gaatagatca atggggaatg    2100

cagtgttggc gggttttctt gttagtggca agtatgaccc agatcttgga gatttcaaaa    2160

ccattgaaga acttgaaaag ctaaaaccag gggagaaagc aaacatctta ctttatcaag    2220

gaaagcccgt taaagtagtt aaaaggaaaa gatatagtgc tttatccaat gacatttcac    2280

aaggaattaa gagacaaaga atgacagttg agtccatggg gtgggccttg agctaatata    2340

aatttatcca ttaattcaat gaatacaatt gagtgaaaaa tgctcgtgtt tctact        2396


<210> 4
<211> 770
<212> PRT
<213> Artificial Sequence

<220> 
<223> PB2 G427S

<400> 4
Met Thr Leu Ala Lys Ile Glu Leu Leu Lys Gln Leu Leu Arg Asp Asn 
1               5                   10                  15      
Glu Ala Lys Thr Val Leu Lys Gln Thr Thr Val Asp Gln Tyr Asn Ile 
            20                  25                  30          
Ile Arg Lys Phe Asn Thr Ser Arg Ile Glu Lys Asn Pro Ser Leu Arg 
        35                  40                  45              
Met Lys Trp Ala Met Cys Ser Asn Phe Pro Leu Ala Leu Thr Lys Gly 
    50                  55                  60                  
Asp Met Ala Asn Arg Ile Pro Leu Glu Tyr Lys Gly Ile Gln Leu Lys 
65                  70                  75                  80  
Thr Asn Ala Glu Asp Ile Gly Thr Lys Gly Gln Met Cys Ser Ile Ala 
                85                  90                  95      
Ala Val Thr Trp Trp Asn Thr Tyr Gly Pro Ile Gly Asp Thr Glu Gly 
            100                 105                 110         
Phe Glu Lys Val Tyr Glu Ser Phe Phe Leu Arg Lys Met Arg Leu Asp 
        115                 120                 125             
Asn Ala Thr Trp Gly Arg Ile Thr Phe Gly Pro Val Glu Arg Val Arg 
    130                 135                 140                 
Lys Arg Val Leu Leu Asn Pro Leu Thr Lys Glu Met Pro Pro Asp Glu 
145                 150                 155                 160 
Ala Ser Asn Val Ile Met Glu Ile Leu Phe Pro Lys Glu Ala Gly Ile 
                165                 170                 175     
Pro Arg Glu Ser Thr Trp Ile His Arg Glu Leu Ile Lys Glu Lys Arg 
            180                 185                 190         
Glu Lys Leu Lys Gly Thr Met Ile Thr Pro Ile Val Leu Ala Tyr Met 
        195                 200                 205             
Leu Glu Arg Glu Leu Val Ala Arg Arg Arg Phe Leu Pro Val Ala Gly 
    210                 215                 220                 
Ala Thr Ser Ala Glu Phe Ile Glu Met Leu His Cys Leu Gln Gly Glu 
225                 230                 235                 240 
Asn Trp Arg Gln Ile Tyr His Pro Gly Gly Asn Lys Leu Thr Glu Ser 
                245                 250                 255     
Arg Ser Gln Ser Met Ile Val Ala Cys Arg Lys Ile Ile Arg Arg Ser 
            260                 265                 270         
Ile Val Ala Ser Asn Pro Leu Glu Leu Ala Val Glu Ile Ala Asn Lys 
        275                 280                 285             
Thr Val Ile Asp Thr Glu Pro Leu Lys Ser Cys Leu Thr Ala Ile Asp 
    290                 295                 300                 
Gly Gly Asp Val Ala Cys Asp Ile Ile Arg Ala Ala Leu Gly Leu Lys 
305                 310                 315                 320 
Ile Arg Gln Arg Gln Arg Phe Gly Arg Leu Glu Leu Lys Arg Ile Ser 
                325                 330                 335     
Gly Arg Gly Phe Lys Asn Asp Glu Glu Ile Leu Ile Gly Asn Gly Thr 
            340                 345                 350         
Ile Gln Lys Ile Gly Ile Trp Asp Gly Glu Glu Glu Phe His Val Arg 
        355                 360                 365             
Cys Gly Glu Cys Arg Gly Ile Leu Lys Lys Ser Lys Met Arg Met Glu 
    370                 375                 380                 
Lys Leu Leu Ile Asn Ser Ala Lys Lys Glu Asp Met Lys Asp Leu Ile 
385                 390                 395                 400 
Ile Leu Cys Met Val Phe Ser Gln Asp Thr Arg Met Phe Gln Gly Val 
                405                 410                 415     
Arg Gly Glu Ile Asn Phe Leu Asn Arg Ala Ser Gln Leu Leu Ser Pro 
            420                 425                 430         
Met Tyr Gln Leu Gln Arg Tyr Phe Leu Ser Arg Ser Asn Asp Leu Phe 
        435                 440                 445             
Asp Gln Trp Gly Tyr Glu Glu Ser Pro Lys Ala Ser Glu Leu His Gly 
    450                 455                 460                 
Ile Asn Glu Leu Met Asn Ala Ser Asp Tyr Thr Leu Lys Gly Val Val 
465                 470                 475                 480 
Val Thr Lys Asn Val Ile Asp Asp Phe Ser Ser Thr Glu Thr Glu Lys 
                485                 490                 495     
Val Ser Ile Thr Lys Asn Leu Ser Leu Ile Lys Arg Thr Gly Glu Val 
            500                 505                 510         
Ile Met Gly Ala Asn Asp Val Ser Glu Leu Glu Ser Gln Ala Gln Leu 
        515                 520                 525             
Met Ile Thr Tyr Asp Thr Pro Lys Met Trp Glu Met Gly Thr Thr Lys 
    530                 535                 540                 
Glu Leu Val Gln Asn Thr Tyr Gln Trp Val Leu Lys Asn Leu Val Thr 
545                 550                 555                 560 
Leu Lys Ala Gln Phe Leu Leu Gly Lys Glu Asp Met Phe Gln Trp Asp 
                565                 570                 575     
Ala Phe Glu Ala Phe Glu Ser Ile Ile Pro Gln Lys Met Ala Gly Gln 
            580                 585                 590         
Tyr Ser Gly Phe Ala Arg Ala Val Leu Lys Gln Met Arg Asp Gln Glu 
        595                 600                 605             
Val Met Lys Thr Asp Gln Phe Ile Lys Leu Leu Pro Phe Cys Phe Ser 
    610                 615                 620                 
Pro Pro Lys Leu Arg Ser Asn Gly Glu Pro Tyr Gln Phe Leu Arg Leu 
625                 630                 635                 640 
Val Leu Lys Gly Gly Gly Glu Asn Phe Ile Glu Val Arg Lys Gly Ser 
                645                 650                 655     
Pro Leu Phe Ser Tyr Asn Pro Gln Thr Glu Val Leu Thr Ile Cys Gly 
            660                 665                 670         
Arg Met Met Ser Leu Lys Gly Lys Ile Glu Asp Glu Glu Arg Asn Arg 
        675                 680                 685             
Ser Met Gly Asn Ala Val Leu Ala Gly Phe Leu Val Ser Gly Lys Tyr 
    690                 695                 700                 
Asp Pro Asp Leu Gly Asp Phe Lys Thr Ile Glu Glu Leu Glu Lys Leu 
705                 710                 715                 720 
Lys Pro Gly Glu Lys Ala Asn Ile Leu Leu Tyr Gln Gly Lys Pro Val 
                725                 730                 735     
Lys Val Val Lys Arg Lys Arg Tyr Ser Ala Leu Ser Asn Asp Ile Ser 
            740                 745                 750         
Gln Gly Ile Lys Arg Gln Arg Met Thr Val Glu Ser Met Gly Trp Ala 
        755                 760                 765             
Leu Ser 
    770 

<210> 5
<211> 1190
<212> DNA
<213> Influenza B virus

<400> 5
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt      60

tcattgacag aagatggaga aggcaaagca gaactagcag aaaaattaca ctgttggttc     120

ggtgggaaag aatttgacct agactctgcc ttggaatgga taaaaaacaa aagatgctta     180

actgatatac agaaagcact aattggtgcc tctatctgct ttttaaaacc caaagaccag     240

gaaagaaaaa gaagattcat cacagagccc ctatcaggaa tgggaacaac agcaacaaaa     300

aagaagggcc tgattctagc tgagagaaaa atgagaaaat gtgtgagctt ccatgaagca     360

tttgaaatag cagaaggcca tgaaagctca gcgttactat attgtctcat ggtcatgtac     420

ctgaatcctg gaaattattc aatgcaagta aaactaggaa cgctctgtgc tttgtgcgaa     480

aaacaagcat cacattcaca cagggctcat agcagagcag cgagatcttc agtgcccgga     540

gtgagacggg aaatgcagat ggtctcagct atgaacacag caaaaacaat gaatggaatg     600

ggaaaaggag aagacgtcca aaaactggca gaagaactgc aaagcaacat tggagtattg     660

agatctcttg gggcaagtca aaagaatggg gaaggaattg caaaggatgt aatggaagtg     720

ctaaagcaga gctctatggg aaattcagct cttgtgaaga aatacctata atgctcgaac     780

catttcagat tctttcaatt tgttctttta ttttatcagc tctccatttc atggcttgga     840

caataggaca tttaaatcaa ataaaaagag gagtaaacat gaaaatacga ataaaggggc     900

caaataaaga gacaataaac agagaggtat caattttgag acacagttac caaaaagaaa     960

tccaggctaa agaagcaatg aaggaagtac tctctgacaa catggaggta ttgagtgacc    1020

acatagtaat tgaggggctt tctgctgaag agataataaa aatgggtgaa acagttttgg    1080

aggtagaaga atttcattaa attcaatttt tactgtactt cttactatgc atttaagcaa    1140

attgtaatca atgtcagcaa ataaactgga aaaagtgcgt tgtttctact               1190


<210> 6
<211> 248
<212> PRT
<213> Influenza B virus

<400> 6
Met Ser Leu Phe Gly Asp Thr Ile Ala Tyr Leu Leu Ser Leu Thr Glu 
1               5                   10                  15      
Asp Gly Glu Gly Lys Ala Glu Leu Ala Glu Lys Leu His Cys Trp Phe 
            20                  25                  30          
Gly Gly Lys Glu Phe Asp Leu Asp Ser Ala Leu Glu Trp Ile Lys Asn 
        35                  40                  45              
Lys Arg Cys Leu Thr Asp Ile Gln Lys Ala Leu Ile Gly Ala Ser Ile 
    50                  55                  60                  
Cys Phe Leu Lys Pro Lys Asp Gln Glu Arg Lys Arg Arg Phe Ile Thr 
65                  70                  75                  80  
Glu Pro Leu Ser Gly Met Gly Thr Thr Ala Thr Lys Lys Lys Gly Leu 
                85                  90                  95      
Ile Leu Ala Glu Arg Lys Met Arg Lys Cys Val Ser Phe His Glu Ala 
            100                 105                 110         
Phe Glu Ile Ala Glu Gly His Glu Ser Ser Ala Leu Leu Tyr Cys Leu 
        115                 120                 125             
Met Val Met Tyr Leu Asn Pro Gly Asn Tyr Ser Met Gln Val Lys Leu 
    130                 135                 140                 
Gly Thr Leu Cys Ala Leu Cys Glu Lys Gln Ala Ser His Ser His Arg 
145                 150                 155                 160 
Ala His Ser Arg Ala Ala Arg Ser Ser Val Pro Gly Val Arg Arg Glu 
                165                 170                 175     
Met Gln Met Val Ser Ala Met Asn Thr Ala Lys Thr Met Asn Gly Met 
            180                 185                 190         
Gly Lys Gly Glu Asp Val Gln Lys Leu Ala Glu Glu Leu Gln Ser Asn 
        195                 200                 205             
Ile Gly Val Leu Arg Ser Leu Gly Ala Ser Gln Lys Asn Gly Glu Gly 
    210                 215                 220                 
Ile Ala Lys Asp Val Met Glu Val Leu Lys Gln Ser Ser Met Gly Asn 
225                 230                 235                 240 
Ser Ala Leu Val Lys Lys Tyr Leu 
                245             

<210> 7
<211> 1190
<212> DNA
<213> Artificial Sequence

<220> 
<223> PB2 T89S

<400> 7
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt      60

tcattgacag aagatggaga aggcaaagca gaactagcag aaaaattaca ctgttggttc     120

ggtgggaaag aatttgacct agactctgcc ttggaatgga taaaaaacaa aagatgctta     180

actgatatac agaaagcact aattggtgcc tctatctgct ttttaaaacc caaagaccag     240

gaaagaaaaa gaagattcat cacagagccc ctatcaggaa tgggaacatc agcaacaaaa     300

aagaagggcc tgattctagc tgagagaaaa atgagaaaat gtgtgagctt ccatgaagca     360

tttgaaatag cagaaggcca tgaaagctca gcgttactat attgtctcat ggtcatgtac     420

ctgaatcctg gaaattattc aatgcaagta aaactaggaa cgctctgtgc tttgtgcgaa     480

aaacaagcat cacattcaca cagggctcat agcagagcag cgagatcttc agtgcccgga     540

gtgagacggg aaatgcagat ggtctcagct atgaacacag caaaaacaat gaatggaatg     600

ggaaaaggag aagacgtcca aaaactggca gaagaactgc aaagcaacat tggagtattg     660

agatctcttg gggcaagtca aaagaatggg gaaggaattg caaaggatgt aatggaagtg     720

ctaaagcaga gctctatggg aaattcagct cttgtgaaga aatacctata atgctcgaac     780

catttcagat tctttcaatt tgttctttta ttttatcagc tctccatttc atggcttgga     840

caataggaca tttaaatcaa ataaaaagag gagtaaacat gaaaatacga ataaaggggc     900

caaataaaga gacaataaac agagaggtat caattttgag acacagttac caaaaagaaa     960

tccaggctaa agaagcaatg aaggaagtac tctctgacaa catggaggta ttgagtgacc    1020

acatagtaat tgaggggctt tctgctgaag agataataaa aatgggtgaa acagttttgg    1080

aggtagaaga atttcattaa attcaatttt tactgtactt cttactatgc atttaagcaa    1140

attgtaatca atgtcagcaa ataaactgga aaaagtgcgt tgtttctact               1190


<210> 8
<211> 248
<212> PRT
<213> Artificial Sequence

<220> 
<223> PB2 T89S

<400> 8
Met Ser Leu Phe Gly Asp Thr Ile Ala Tyr Leu Leu Ser Leu Thr Glu 
1               5                   10                  15      
Asp Gly Glu Gly Lys Ala Glu Leu Ala Glu Lys Leu His Cys Trp Phe 
            20                  25                  30          
Gly Gly Lys Glu Phe Asp Leu Asp Ser Ala Leu Glu Trp Ile Lys Asn 
        35                  40                  45              
Lys Arg Cys Leu Thr Asp Ile Gln Lys Ala Leu Ile Gly Ala Ser Ile 
    50                  55                  60                  
Cys Phe Leu Lys Pro Lys Asp Gln Glu Arg Lys Arg Arg Phe Ile Thr 
65                  70                  75                  80  
Glu Pro Leu Ser Gly Met Gly Thr Ser Ala Thr Lys Lys Lys Gly Leu 
                85                  90                  95      
Ile Leu Ala Glu Arg Lys Met Arg Lys Cys Val Ser Phe His Glu Ala 
            100                 105                 110         
Phe Glu Ile Ala Glu Gly His Glu Ser Ser Ala Leu Leu Tyr Cys Leu 
        115                 120                 125             
Met Val Met Tyr Leu Asn Pro Gly Asn Tyr Ser Met Gln Val Lys Leu 
    130                 135                 140                 
Gly Thr Leu Cys Ala Leu Cys Glu Lys Gln Ala Ser His Ser His Arg 
145                 150                 155                 160 
Ala His Ser Arg Ala Ala Arg Ser Ser Val Pro Gly Val Arg Arg Glu 
                165                 170                 175     
Met Gln Met Val Ser Ala Met Asn Thr Ala Lys Thr Met Asn Gly Met 
            180                 185                 190         
Gly Lys Gly Glu Asp Val Gln Lys Leu Ala Glu Glu Leu Gln Ser Asn 
        195                 200                 205             
Ile Gly Val Leu Arg Ser Leu Gly Ala Ser Gln Lys Asn Gly Glu Gly 
    210                 215                 220                 
Ile Ala Lys Asp Val Met Glu Val Leu Lys Gln Ser Ser Met Gly Asn 
225                 230                 235                 240 
Ser Ala Leu Val Lys Lys Tyr Leu 
                245             

<210> 9
<211> 442
<212> DNA
<213> Influenza B virus

<400> 9
agcagaagca gaggatttgt ttagtcactg gcaaacagga aaaatggcgg acaatatgac      60

cacaacacaa attgagtgga ggatgaagaa gatggccatc ggatcctcaa ttcactcttc     120

gagcgtctta atgaaggaca ttcaaagcca attcgagcag ctgaaactgc ggtgggagtc     180

ttatcccaat ttggtcaaga gcaccgatta tcaccagaag agggagacaa ttagactggt     240

cacggaagaa ctttatcttt taagtaaaag aattgatgat aacatattgt tccacaaaac     300

agtaatagct aacagctcca taatagctga catggttgta tcattatcat tattagaaac     360

attgtatgaa atgaaggatg tggttgaagt gtacagcagg cagtgcttgt gaatttaaaa     420

taaaaatcct cttgttacta ct                                              442


<210> 10
<211> 122
<212> PRT
<213> Influenza B virus

<400> 10
Met Ala Asp Asn Met Thr Thr Thr Gln Ile Glu Trp Arg Met Lys Lys 
1               5                   10                  15      
Met Ala Ile Gly Ser Ser Ile His Ser Ser Ser Val Leu Met Lys Asp 
            20                  25                  30          
Ile Gln Ser Gln Phe Glu Gln Leu Lys Leu Arg Trp Glu Ser Tyr Pro 
        35                  40                  45              
Asn Leu Val Lys Ser Thr Asp Tyr His Gln Lys Arg Glu Thr Ile Arg 
    50                  55                  60                  
Leu Val Thr Glu Glu Leu Tyr Leu Leu Ser Lys Lys Ile Asp Asp Asn 
65                  70                  75                  80  
Ile Leu Phe His Lys Thr Val Ile Ala Asn Ser Ser Ile Ile Ala Asp 
                85                  90                  95      
Met Val Val Ser Leu Ser Leu Leu Glu Thr Leu Tyr Glu Met Lys Asp 
            100                 105                 110         
Val Val Glu Val Tyr Ser Arg Gln Cys Leu 
        115                 120         

<210> 11
<211> 442
<212> DNA
<213> Artificial Sequence

<220> 
<223> NS2 K75R R76G

<400> 11
agcagaagca gaggatttgt ttagtcactg gcaaacagga aaaatggcgg acaatatgac      60

cacaacacaa attgagtgga ggatgaagaa gatggccatc ggatcctcaa ttcactcttc     120

gagcgtctta atgaaggaca ttcaaagcca attcgagcag ctgaaactgc ggtgggagtc     180

ttatcccaat ttggtcaaga gcaccgatta tcaccagaag agggagacaa ttagactggt     240

cacggaagaa ctttatcttt taagtagagg aattgatgat aacatattgt tccacaaaac     300

agtaatagct aacagctcca taatagctga catggttgta tcattatcat tattagaaac     360

attgtatgaa atgaaggatg tggttgaagt gtacagcagg cagtgcttgt gaatttaaaa     420

taaaaatcct cttgttacta ct                                              442


<210> 12
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> NS2 K75R R76G

<400> 12
Met Ala Asp Asn Met Thr Thr Thr Gln Ile Glu Trp Arg Met Lys Lys 
1               5                   10                  15      
Met Ala Ile Gly Ser Ser Ile His Ser Ser Ser Val Leu Met Lys Asp 
            20                  25                  30          
Ile Gln Ser Gln Phe Glu Gln Leu Lys Leu Arg Trp Glu Ser Tyr Pro 
        35                  40                  45              
Asn Leu Val Lys Ser Thr Asp Tyr His Gln Lys Arg Glu Thr Ile Arg 
    50                  55                  60                  
Leu Val Thr Glu Glu Leu Tyr Leu Leu Ser Arg Gly Ile Asp Asp Asn 
65                  70                  75                  80  
Ile Leu Phe His Lys Thr Val Ile Ala Asn Ser Ser Ile Ile Ala Asp 
                85                  90                  95      
Met Val Val Ser Leu Ser Leu Leu Glu Thr Leu Tyr Glu Met Lys Asp 
            100                 105                 110         
Val Val Glu Val Tyr Ser Arg 
        115                 

<210> 13
<211> 2369
<212> DNA
<213> Influenza B virus

<400> 13
agcagaagcg gagcctttaa gatgaatata aatccttatt ttctcttcat agatgtaccc      60

atacaggcag caatttcaac aacattccca tacaccggtg ttccccctta ttcccatgga     120

acgggaacag gctacacaat agacaccgtg atcagaacac atgagtactc gaacaaagga     180

aaacagtatg tttctgacat cacaggatgt acaatgatag atccaacaaa tgggccatta     240

cctgaagaca atgagccaag tgcctatgca caattagatt gcgttctgga ggctttggat     300

agaatggatg aggaacatcc aggtctgttt caagcagcct cacagaatgc catggaggca     360

ctaatggtca caactgtaga caaattaacc caggggagac agactttcga ttggacagta     420

tgcagaaacc agcctgctgc aacggcacta aacacaacaa taacctcctt cagattgaat     480

gatttgaatg gagctgacaa gggtggattg gtaccctttt gccaagatat cattgattca     540

ttagacaagc ctgaaatgac tttcttctca gtaaagaata taaagaaaaa attgcctgct     600

aaaaacagaa agggtttcct cataaagaga ataccaatga aagtaaaaga caggatatcc     660

agagtggaat acatcaaaag agcattgtca ttaaacacaa tgacaaaaga tgctgaaagg     720

ggcaaactaa aaagaagagc gattgcaacc gctggaatac aaatcagagg gtttgtatta     780

gtagttgaaa acttggctaa aaacatctgt gaaaatctag aacaaagtgg tttgcccgtg     840

ggtggaaatg aaaagaaggc caaactgtca aatgcagtgg ccaaaatgct cagtaactgc     900

ccaccaggag ggatcagcat gacagtaaca ggagacaata ctaaatggaa tgaatgctta     960

aatccacgaa tctttttggc tatgactgaa agaataacca gagacagccc aatttggttc    1020

cgggattttt gtagtatagc accggtcttg ttctccaaca aaatagccag attggggaaa    1080

ggatttatga taacaagtaa aacaaaaaga ctaaaggctc aaataccttg tcctgatctg    1140

ttcagcatac cattagaaag atataatgaa gaaacaaggg cgaaattaaa aaggctgaag    1200

ccattcttca atgaagaagg aacggcatct ttgtcgcctg ggatgatgat gggaatgttt    1260

aatatgctat ctaccgtgtt gggagtagca gcactaggca tcaaaaacat tggaaacaag    1320

gaatacttat gggatggact gcaatcttcc gatgattttg ctttgtttgt taatgcaaaa    1380

gatgaagaaa catgtatgga agggataaac gatttttacc gaacatgtaa attattggga    1440

ataaacatga gcaaaaagaa aagttactgt aacgaaactg gaatgtttga atttacaagc    1500

atgttctata gagatggatt tgtatctaac tttgcaatgg aaattccttc atttggagtt    1560

gctggagtaa atgaatcagc agatatggca ataggaatga caataataaa gaacaatatg    1620

attaacaatg ggatgggtcc agcaacagca caaacagcca tacaattgtt catagctgat    1680

tataggtaca catacaaatg ccacagagga gattccaaag tggaaggaaa aagaatgaaa    1740

attataaagg agctatggga aaacactaaa ggaagagatg gtctgttagt agcagatggt    1800

gggcccaaca tttacaattt gagaaactta catatcccag aaatagtatt gaagtacaac    1860

ctaatggacc ctgaatacaa agggcggtta cttcaccctc aaaatccctt tgtaggacat    1920

ttgtctattg aaggcatcaa agaagcagat ataaccccag cacatggtcc tgtgaggaaa    1980

atggattatg atgcagtgtc tggaactcat agttggagaa ccaaaaggaa cagatctata    2040

ctaaatactg atcagaggaa catgattctt gaagaacaat gctacgctaa atgttgcaat    2100

ctttttgagg cctgttttaa cagtgcatca tacaggaaac cagtagggca gcatagcatg    2160

cttgaggcta tggcccatag attaagaatg gatgcacgac tagattatga atcaggaaga    2220

atgtcaaagg atgattttga gaaagcaatg gctcaccttg gtgagattgg gtacacataa    2280

gctccgaaga tgtccatggg gttattggtc atcattggat acatgtgata aacaaatgat    2340

taaaatgaaa aaaggctcgt gtttctact                                      2369


<210> 14
<211> 752
<212> PRT
<213> Influenza B virus

<400> 14
Met Asn Ile Asn Pro Tyr Phe Leu Phe Ile Asp Val Pro Ile Gln Ala 
1               5                   10                  15      
Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Val Pro Pro Tyr Ser His 
            20                  25                  30          
Gly Thr Gly Thr Gly Tyr Thr Ile Asp Thr Val Ile Arg Thr His Glu 
        35                  40                  45              
Tyr Ser Asn Lys Gly Lys Gln Tyr Val Ser Asp Ile Thr Gly Cys Thr 
    50                  55                  60                  
Met Ile Asp Pro Thr Asn Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  
Ala Tyr Ala Gln Leu Asp Cys Val Leu Glu Ala Leu Asp Arg Met Asp 
                85                  90                  95      
Glu Glu His Pro Gly Leu Phe Gln Ala Ala Ser Gln Asn Ala Met Glu 
            100                 105                 110         
Ala Leu Met Val Thr Thr Val Asp Lys Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             
Phe Asp Trp Thr Val Cys Arg Asn Gln Pro Ala Ala Thr Ala Leu Asn 
    130                 135                 140                 
Thr Thr Ile Thr Ser Phe Arg Leu Asn Asp Leu Asn Gly Ala Asp Lys 
145                 150                 155                 160 
Gly Gly Leu Val Pro Phe Cys Gln Asp Ile Ile Asp Ser Leu Asp Lys 
                165                 170                 175     
Pro Glu Met Thr Phe Phe Ser Val Lys Asn Ile Lys Lys Lys Leu Pro 
            180                 185                 190         
Ala Lys Asn Arg Lys Gly Phe Leu Ile Lys Arg Ile Pro Met Lys Val 
        195                 200                 205             
Lys Asp Arg Ile Ser Arg Val Glu Tyr Ile Lys Arg Ala Leu Ser Leu 
    210                 215                 220                 
Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 
Ile Ala Thr Ala Gly Ile Gln Ile Arg Gly Phe Val Leu Val Val Glu 
                245                 250                 255     
Asn Leu Ala Lys Asn Ile Cys Glu Asn Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         
Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ser Asn Ala Val Ala Lys 
        275                 280                 285             
Met Leu Ser Asn Cys Pro Pro Gly Gly Ile Ser Met Thr Val Thr Gly 
    290                 295                 300                 
Asp Asn Thr Lys Trp Asn Glu Cys Leu Asn Pro Arg Ile Phe Leu Ala 
305                 310                 315                 320 
Met Thr Glu Arg Ile Thr Arg Asp Ser Pro Ile Trp Phe Arg Asp Phe 
                325                 330                 335     
Cys Ser Ile Ala Pro Val Leu Phe Ser Asn Lys Ile Ala Arg Leu Gly 
            340                 345                 350         
Lys Gly Phe Met Ile Thr Ser Lys Thr Lys Arg Leu Lys Ala Gln Ile 
        355                 360                 365             
Pro Cys Pro Asp Leu Phe Ser Ile Pro Leu Glu Arg Tyr Asn Glu Glu 
    370                 375                 380                 
Thr Arg Ala Lys Leu Lys Arg Leu Lys Pro Phe Phe Asn Glu Glu Gly 
385                 390                 395                 400 
Thr Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu 
                405                 410                 415     
Ser Thr Val Leu Gly Val Ala Ala Leu Gly Ile Lys Asn Ile Gly Asn 
            420                 425                 430         
Lys Glu Tyr Leu Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala Leu 
        435                 440                 445             
Phe Val Asn Ala Lys Asp Glu Glu Thr Cys Met Glu Gly Ile Asn Asp 
    450                 455                 460                 
Phe Tyr Arg Thr Cys Lys Leu Leu Gly Ile Asn Met Ser Lys Lys Lys 
465                 470                 475                 480 
Ser Tyr Cys Asn Glu Thr Gly Met Phe Glu Phe Thr Ser Met Phe Tyr 
                485                 490                 495     
Arg Asp Gly Phe Val Ser Asn Phe Ala Met Glu Ile Pro Ser Phe Gly 
            500                 505                 510         
Val Ala Gly Val Asn Glu Ser Ala Asp Met Ala Ile Gly Met Thr Ile 
        515                 520                 525             
Ile Lys Asn Asn Met Ile Asn Asn Gly Met Gly Pro Ala Thr Ala Gln 
    530                 535                 540                 
Thr Ala Ile Gln Leu Phe Ile Ala Asp Tyr Arg Tyr Thr Tyr Lys Cys 
545                 550                 555                 560 
His Arg Gly Asp Ser Lys Val Glu Gly Lys Arg Met Lys Ile Ile Lys 
                565                 570                 575     
Glu Leu Trp Glu Asn Thr Lys Gly Arg Asp Gly Leu Leu Val Ala Asp 
            580                 585                 590         
Gly Gly Pro Asn Ile Tyr Asn Leu Arg Asn Leu His Ile Pro Glu Ile 
        595                 600                 605             
Val Leu Lys Tyr Asn Leu Met Asp Pro Glu Tyr Lys Gly Arg Leu Leu 
    610                 615                 620                 
His Pro Gln Asn Pro Phe Val Gly His Leu Ser Ile Glu Gly Ile Lys 
625                 630                 635                 640 
Glu Ala Asp Ile Thr Pro Ala His Gly Pro Val Arg Lys Met Asp Tyr 
                645                 650                 655     
Asp Ala Val Ser Gly Thr His Ser Trp Arg Thr Lys Arg Asn Arg Ser 
            660                 665                 670         
Ile Leu Asn Thr Asp Gln Arg Asn Met Ile Leu Glu Glu Gln Cys Tyr 
        675                 680                 685             
Ala Lys Cys Cys Asn Leu Phe Glu Ala Cys Phe Asn Ser Ala Ser Tyr 
    690                 695                 700                 
Arg Lys Pro Val Gly Gln His Ser Met Leu Glu Ala Met Ala His Arg 
705                 710                 715                 720 
Leu Arg Met Asp Ala Arg Leu Asp Tyr Glu Ser Gly Arg Met Ser Lys 
                725                 730                 735     
Asp Asp Phe Glu Lys Ala Met Ala His Leu Gly Glu Ile Gly Tyr Thr 
            740                 745                 750         



<210> 15
<211> 2369
<212> DNA
<213> Artificial Sequence

<220> 
<223> PB1 D67N

<400> 15
agcagaagcg gagcctttaa gatgaatata aatccttatt ttctcttcat agatgtaccc      60

atacaggcag caatttcaac aacattccca tacaccggtg ttccccctta ttcccatgga     120

acgggaacag gctacacaat agacaccgtg atcagaacac atgagtactc gaacaaagga     180

aaacagtatg tttctgacat cacaggatgt acaatgataa atccaacaaa tgggccatta     240

cctgaagaca atgagccaag tgcctatgca caattagatt gcgttctgga ggctttggat     300

agaatggatg aggaacatcc aggtctgttt caagcagcct cacagaatgc catggaggca     360

ctaatggtca caactgtaga caaattaacc caggggagac agactttcga ttggacagta     420

tgcagaaacc agcctgctgc aacggcacta aacacaacaa taacctcctt cagattgaat     480

gatttgaatg gagctgacaa gggtggattg gtaccctttt gccaagatat cattgattca     540

ttagacaagc ctgaaatgac tttcttctca gtaaagaata taaagaaaaa attgcctgct     600

aaaaacagaa agggtttcct cataaagaga ataccaatga aagtaaaaga caggatatcc     660

agagtggaat acatcaaaag agcattgtca ttaaacacaa tgacaaaaga tgctgaaagg     720

ggcaaactaa aaagaagagc gattgcaacc gctggaatac aaatcagagg gtttgtatta     780

gtagttgaaa acttggctaa aaacatctgt gaaaatctag aacaaagtgg tttgcccgtg     840

ggtggaaatg aaaagaaggc caaactgtca aatgcagtgg ccaaaatgct cagtaactgc     900

ccaccaggag ggatcagcat gacagtaaca ggagacaata ctaaatggaa tgaatgctta     960

aatccacgaa tctttttggc tatgactgaa agaataacca gagacagccc aatttggttc    1020

cgggattttt gtagtatagc accggtcttg ttctccaaca aaatagccag attggggaaa    1080

ggatttatga taacaagtaa aacaaaaaga ctaaaggctc aaataccttg tcctgatctg    1140

ttcagcatac cattagaaag atataatgaa gaaacaaggg cgaaattaaa aaggctgaag    1200

ccattcttca atgaagaagg aacggcatct ttgtcgcctg ggatgatgat gggaatgttt    1260

aatatgctat ctaccgtgtt gggagtagca gcactaggca tcaaaaacat tggaaacaag    1320

gaatacttat gggatggact gcaatcttcc gatgattttg ctttgtttgt taatgcaaaa    1380

gatgaagaaa catgtatgga agggataaac gatttttacc gaacatgtaa attattggga    1440

ataaacatga gcaaaaagaa aagttactgt aacgaaactg gaatgtttga atttacaagc    1500

atgttctata gagatggatt tgtatctaac tttgcaatgg aaattccttc atttggagtt    1560

gctggagtaa atgaatcagc agatatggca ataggaatga caataataaa gaacaatatg    1620

attaacaatg ggatgggtcc agcaacagca caaacagcca tacaattgtt catagctgat    1680

tataggtaca catacaaatg ccacagagga gattccaaag tggaaggaaa aagaatgaaa    1740

attataaagg agctatggga aaacactaaa ggaagagatg gtctgttagt agcagatggt    1800

gggcccaaca tttacaattt gagaaactta catatcccag aaatagtatt gaagtacaac    1860

ctaatggacc ctgaatacaa agggcggtta cttcaccctc aaaatccctt tgtaggacat    1920

ttgtctattg aaggcatcaa agaagcagat ataaccccag cacatggtcc tgtgaggaaa    1980

atggattatg atgcagtgtc tggaactcat agttggagaa ccaaaaggaa cagatctata    2040

ctaaatactg atcagaggaa catgattctt gaagaacaat gctacgctaa atgttgcaat    2100

ctttttgagg cctgttttaa cagtgcatca tacaggaaac cagtagggca gcatagcatg    2160

cttgaggcta tggcccatag attaagaatg gatgcacgac tagattatga atcaggaaga    2220

atgtcaaagg atgattttga gaaagcaatg gctcaccttg gtgagattgg gtacacataa    2280

gctccgaaga tgtccatggg gttattggtc atcattggat acatgtgata aacaaatgat    2340

taaaatgaaa aaaggctcgt gtttctact                                      2369


<210> 16
<211> 752
<212> PRT
<213> Artificial Sequence

<220> 
<223> PB1 D67N

<400> 16
Met Asn Ile Asn Pro Tyr Phe Leu Phe Ile Asp Val Pro Ile Gln Ala 
1               5                   10                  15      
Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Val Pro Pro Tyr Ser His 
            20                  25                  30          
Gly Thr Gly Thr Gly Tyr Thr Ile Asp Thr Val Ile Arg Thr His Glu 
        35                  40                  45              
Tyr Ser Asn Lys Gly Lys Gln Tyr Val Ser Asp Ile Thr Gly Cys Thr 
    50                  55                  60                  
Met Ile Asn Pro Thr Asn Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  
Ala Tyr Ala Gln Leu Asp Cys Val Leu Glu Ala Leu Asp Arg Met Asp 
                85                  90                  95      
Glu Glu His Pro Gly Leu Phe Gln Ala Ala Ser Gln Asn Ala Met Glu 
            100                 105                 110         
Ala Leu Met Val Thr Thr Val Asp Lys Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             
Phe Asp Trp Thr Val Cys Arg Asn Gln Pro Ala Ala Thr Ala Leu Asn 
    130                 135                 140                 
Thr Thr Ile Thr Ser Phe Arg Leu Asn Asp Leu Asn Gly Ala Asp Lys 
145                 150                 155                 160 
Gly Gly Leu Val Pro Phe Cys Gln Asp Ile Ile Asp Ser Leu Asp Lys 
                165                 170                 175     
Pro Glu Met Thr Phe Phe Ser Val Lys Asn Ile Lys Lys Lys Leu Pro 
            180                 185                 190         
Ala Lys Asn Arg Lys Gly Phe Leu Ile Lys Arg Ile Pro Met Lys Val 
        195                 200                 205             
Lys Asp Arg Ile Ser Arg Val Glu Tyr Ile Lys Arg Ala Leu Ser Leu 
    210                 215                 220                 
Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 
Ile Ala Thr Ala Gly Ile Gln Ile Arg Gly Phe Val Leu Val Val Glu 
                245                 250                 255     
Asn Leu Ala Lys Asn Ile Cys Glu Asn Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         
Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ser Asn Ala Val Ala Lys 
        275                 280                 285             
Met Leu Ser Asn Cys Pro Pro Gly Gly Ile Ser Met Thr Val Thr Gly 
    290                 295                 300                 
Asp Asn Thr Lys Trp Asn Glu Cys Leu Asn Pro Arg Ile Phe Leu Ala 
305                 310                 315                 320 
Met Thr Glu Arg Ile Thr Arg Asp Ser Pro Ile Trp Phe Arg Asp Phe 
                325                 330                 335     
Cys Ser Ile Ala Pro Val Leu Phe Ser Asn Lys Ile Ala Arg Leu Gly 
            340                 345                 350         
Lys Gly Phe Met Ile Thr Ser Lys Thr Lys Arg Leu Lys Ala Gln Ile 
        355                 360                 365             
Pro Cys Pro Asp Leu Phe Ser Ile Pro Leu Glu Arg Tyr Asn Glu Glu 
    370                 375                 380                 
Thr Arg Ala Lys Leu Lys Arg Leu Lys Pro Phe Phe Asn Glu Glu Gly 
385                 390                 395                 400 
Thr Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu 
                405                 410                 415     
Ser Thr Val Leu Gly Val Ala Ala Leu Gly Ile Lys Asn Ile Gly Asn 
            420                 425                 430         
Lys Glu Tyr Leu Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala Leu 
        435                 440                 445             
Phe Val Asn Ala Lys Asp Glu Glu Thr Cys Met Glu Gly Ile Asn Asp 
    450                 455                 460                 
Phe Tyr Arg Thr Cys Lys Leu Leu Gly Ile Asn Met Ser Lys Lys Lys 
465                 470                 475                 480 
Ser Tyr Cys Asn Glu Thr Gly Met Phe Glu Phe Thr Ser Met Phe Tyr 
                485                 490                 495     
Arg Asp Gly Phe Val Ser Asn Phe Ala Met Glu Ile Pro Ser Phe Gly 
            500                 505                 510         
Val Ala Gly Val Asn Glu Ser Ala Asp Met Ala Ile Gly Met Thr Ile 
        515                 520                 525             
Ile Lys Asn Asn Met Ile Asn Asn Gly Met Gly Pro Ala Thr Ala Gln 
    530                 535                 540                 
Thr Ala Ile Gln Leu Phe Ile Ala Asp Tyr Arg Tyr Thr Tyr Lys Cys 
545                 550                 555                 560 
His Arg Gly Asp Ser Lys Val Glu Gly Lys Arg Met Lys Ile Ile Lys 
                565                 570                 575     
Glu Leu Trp Glu Asn Thr Lys Gly Arg Asp Gly Leu Leu Val Ala Asp 
            580                 585                 590         
Gly Gly Pro Asn Ile Tyr Asn Leu Arg Asn Leu His Ile Pro Glu Ile 
        595                 600                 605             
Val Leu Lys Tyr Asn Leu Met Asp Pro Glu Tyr Lys Gly Arg Leu Leu 
    610                 615                 620                 
His Pro Gln Asn Pro Phe Val Gly His Leu Ser Ile Glu Gly Ile Lys 
625                 630                 635                 640 
Glu Ala Asp Ile Thr Pro Ala His Gly Pro Val Arg Lys Met Asp Tyr 
                645                 650                 655     
Asp Ala Val Ser Gly Thr His Ser Trp Arg Thr Lys Arg Asn Arg Ser 
            660                 665                 670         
Ile Leu Asn Thr Asp Gln Arg Asn Met Ile Leu Glu Glu Gln Cys Tyr 
        675                 680                 685             
Ala Lys Cys Cys Asn Leu Phe Glu Ala Cys Phe Asn Ser Ala Ser Tyr 
    690                 695                 700                 
Arg Lys Pro Val Gly Gln His Ser Met Leu Glu Ala Met Ala His Arg 
705                 710                 715                 720 
Leu Arg Met Asp Ala Arg Leu Asp Tyr Glu Ser Gly Arg Met Ser Lys 
                725                 730                 735     
Asp Asp Phe Glu Lys Ala Met Ala His Leu Gly Glu Ile Gly Tyr Thr 
            740                 745                 750         



<210> 17
<211> 32
<212> PRT
<213> Influenza B virus

<400> 17
Cys Gly Cys Ala Gly Thr Cys Gly Gly Thr Ala Cys Thr Thr Thr Thr 
1               5                   10                  15      
Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Val Asn 
            20                  25                  30          



<210> 18
<211> 33
<212> PRT
<213> Influenza B virus

<400> 18
Ala Ala Gly Cys Ala Gly Thr Gly Gly Thr Ala Thr Cys Ala Ala Cys 
1               5                   10                  15      
Gly Cys Ala Gly Ala Gly Thr Ala Cys Gly Cys Arg Gly Arg Gly Arg 
            20                  25                  30          
Gly 
    

<210> 19
<211> 1190
<212> DNA
<213> Artificial Sequence

<220> 
<223> M1 K93R

<400> 19
agcagaagca cgcactttct taaaatgtcg ctgtttggag acacaattgc ctacctgctt      60

tcattgacag aagatggaga aggcaaagca gaactagcag aaaaattaca ctgttggttc     120

ggtgggaaag aatttgacct agactctgcc ttggaatgga taaaaaacaa aagatgctta     180

actgatatac agaaagcact aattggtgcc tctatctgct ttttaaaacc caaagaccag     240

gaaagaaaaa gaagattcat cacagagccc ctatcaggaa tgggaacaac agcaacaaaa     300

aggaagggcc tgattctagc tgagagaaaa atgagaaaat gtgtgagctt ccatgaagca     360

tttgaaatag cagaaggcca tgaaagctca gcgttactat attgtctcat ggtcatgtac     420

ctgaatcctg gaaattattc aatgcaagta aaactaggaa cgctctgtgc tttgtgcgaa     480

aaacaagcat cacattcaca cagggctcat agcagagcag cgagatcttc agtgcccgga     540

gtgagacggg aaatgcagat ggtctcagct atgaacacag caaaaacaat gaatggaatg     600

ggaaaaggag aagacgtcca aaaactggca gaagaactgc aaagcaacat tggagtattg     660

agatctcttg gggcaagtca aaagaatggg gaaggaattg caaaggatgt aatggaagtg     720

ctaaagcaga gctctatggg aaattcagct cttgtgaaga aatacctata atgctcgaac     780

catttcagat tctttcaatt tgttctttta ttttatcagc tctccatttc atggcttgga     840

caataggaca tttaaatcaa ataaaaagag gagtaaacat gaaaatacga ataaaggggc     900

caaataaaga gacaataaac agagaggtat caattttgag acacagttac caaaaagaaa     960

tccaggctaa agaagcaatg aaggaagtac tctctgacaa catggaggta ttgagtgacc    1020

acatagtaat tgaggggctt tctgctgaag agataataaa aatgggtgaa acagttttgg    1080

aggtagaaga atttcattaa attcaatttt tactgtactt cttactatgc atttaagcaa    1140

attgtaatca atgtcagcaa ataaactgga aaaagtgcgt tgtttctact               1190


<210> 20
<211> 248
<212> PRT
<213> Artificial Sequence

<220> 
<223> M1 K93R

<400> 20
Met Ser Leu Phe Gly Asp Thr Ile Ala Tyr Leu Leu Ser Leu Thr Glu 
1               5                   10                  15      
Asp Gly Glu Gly Lys Ala Glu Leu Ala Glu Lys Leu His Cys Trp Phe 
            20                  25                  30          
Gly Gly Lys Glu Phe Asp Leu Asp Ser Ala Leu Glu Trp Ile Lys Asn 
        35                  40                  45              
Lys Arg Cys Leu Thr Asp Ile Gln Lys Ala Leu Ile Gly Ala Ser Ile 
    50                  55                  60                  
Cys Phe Leu Lys Pro Lys Asp Gln Glu Arg Lys Arg Arg Phe Ile Thr 
65                  70                  75                  80  
Glu Pro Leu Ser Gly Met Gly Thr Thr Ala Thr Lys Arg Lys Gly Leu 
                85                  90                  95      
Ile Leu Ala Glu Arg Lys Met Arg Lys Cys Val Ser Phe His Glu Ala 
            100                 105                 110         
Phe Glu Ile Ala Glu Gly His Glu Ser Ser Ala Leu Leu Tyr Cys Leu 
        115                 120                 125             
Met Val Met Tyr Leu Asn Pro Gly Asn Tyr Ser Met Gln Val Lys Leu 
    130                 135                 140                 
Gly Thr Leu Cys Ala Leu Cys Glu Lys Gln Ala Ser His Ser His Arg 
145                 150                 155                 160 
Ala His Ser Arg Ala Ala Arg Ser Ser Val Pro Gly Val Arg Arg Glu 
                165                 170                 175     
Met Gln Met Val Ser Ala Met Asn Thr Ala Lys Thr Met Asn Gly Met 
            180                 185                 190         
Gly Lys Gly Glu Asp Val Gln Lys Leu Ala Glu Glu Leu Gln Ser Asn 
        195                 200                 205             
Ile Gly Val Leu Arg Ser Leu Gly Ala Ser Gln Lys Asn Gly Glu Gly 
    210                 215                 220                 
Ile Ala Lys Asp Val Met Glu Val Leu Lys Gln Ser Ser Met Gly Asn 
225                 230                 235                 240 
Ser Ala Leu Val Lys Lys Tyr Leu 
                245             

<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 21
cccactgctt actggcttat                                                20


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 22
cagatggctg gcaactagaa                                                20


<210> 23
<211> 442
<212> DNA
<213> Artificial Sequence

<220> 
<223> NS Y117H

<400> 23
agcagaagca gaggatttgt ttagtcactg gcaaacagga aaaatggcgg acaatatgac      60

cacaacacaa attgagtgga ggatgaagaa gatggccatc ggatcctcaa ttcactcttc     120

gagcgtctta atgaaggaca ttcaaagcca attcgagcag ctgaaactgc ggtgggagtc     180

ttatcccaat ttggtcaaga gcaccgatta tcaccagaag agggagacaa ttagactggt     240

cacggaagaa ctttatcttt taagtaaaag aattgatgat aacatattgt tccacaaaac     300

agtaatagct aacagctcca taatagctga catggttgta tcattatcat tattagaaac     360

attgtatgaa atgaaggatg tggttgaagt gcacagcagg cagtgcttgt gaatttaaaa     420

taaaaatcct cttgttacta ct                                              442


<210> 24
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> NS Y117H

<400> 24
Met Ala Asp Asn Met Thr Thr Thr Gln Ile Glu Trp Arg Met Lys Lys 
1               5                   10                  15      
Met Ala Ile Gly Ser Ser Ile His Ser Ser Ser Val Leu Met Lys Asp 
            20                  25                  30          
Ile Gln Ser Gln Phe Glu Gln Leu Lys Leu Arg Trp Glu Ser Tyr Pro 
        35                  40                  45              
Asn Leu Val Lys Ser Thr Asp Tyr His Gln Lys Arg Glu Thr Ile Arg 
    50                  55                  60                  
Leu Val Thr Glu Glu Leu Tyr Leu Leu Ser Lys Arg Ile Asp Asp Asn 
65                  70                  75                  80  
Ile Leu Phe His Lys Thr Val Ile Ala Asn Ser Ser Ile Ile Ala Asp 
                85                  90                  95      
Met Val Val Ser Leu Ser Leu Leu Glu Thr Leu Tyr Glu Met Lys Asp 
            100                 105                 110         
Val Val Glu Val His Ser Arg 
        115                 

<210> 25
<211> 2341
<212> DNA
<213> Influenza A virus

<400> 25
agcgaaagca ggtcaattat attcaatatg gaaagaataa aagaactacg aaatctaatg      60

tcgcagtctc gcacccgcga gatactcaca aaaaccaccg tggaccatat ggccataatc     120

aagaagtaca catcaggaag acaggagaag aacccagcac ttaggatgaa atggatgatg     180

gcaatgaaat atccaattac agcagacaag aggataacgg aaatgattcc tgagagaaat     240

gagcaaggac aaactttatg gagtaaaatg aatgattccg gatcagaccg agtgatggta     300

tcacctctgg ctgtgacatg gtggaatagg aatggaccaa taacaaatac agttcattat     360

ccaaaaatct acaaaactta ttttgaaaga gtcgaaaggc taaagcatgg aacctttggc     420

cctgtccatt ttagaaacca agtcaaaata cgtcggagag ttgacataaa tcctggtcat     480

gcagatctca gtgccaagga ggcacaggat gtaatcatgg aagttgtttt ccctaacgaa     540

gtgggagcca ggatactaac atcggaatcg caactaacga taaccaaaga gaagaaagaa     600

gaactccagg attgcaaaat ttctcctttg atggttgcat acatgttgga gagagaactg     660

gtccgcaaaa cgagattcct cccagtggct ggtggaacaa gcagtgtgta cattgaagtg     720

ttgcatttga ctcaaggaac atgctgggaa cagatgtata ctccaggagg ggaagtgagg     780

aatgatgatg ttgatcaaag cttgattatt gctgctagga acatagtgag aagagctgca     840

gtatcagcag atccactagc atctttattg gagatgtgcc acagcacaca gattggtgga     900

attaggatgg tagacatcct taggcagaac ccaacagaag agcaagccgt ggatatatgc     960

aaggctgcaa tgggactgag aattagctca tccttcagtt ttggtggatt cacatttaag    1020

agaacaagcg gatcatcagt caagagagag gaagaggtgc ttacgggcaa tcttcaaaca    1080

ttgaagataa gagtgcatga gggatatgaa gagttcacaa tggttgggag aagagcaaca    1140

gccatactca gaaaagcaac caggagattg attcagctga tagtgagtgg gagagacgaa    1200

cagtcgattg ccgaagcaat aattgtggcc atggtatttt cacaagagga ttgtatgata    1260

aaagcagtca gaggtgatct gaatttcgtc aatagggcaa atcaacgatt gaatcctatg    1320

catcaacttt taagacattt tcagaaggat gcgaaagtgc tttttcaaaa ttggggagtt    1380

gaacctatcg acaatgtgat gggaatgatt gggatattgc ccgacatgac tccaagcatc    1440

gagatgtcaa tgagaggagt gagaatcagc aaaatgggtg tagatgagta ctccagcacg    1500

gagagggtag tggtgagcat tgaccgtttt ttgagaatcc gggaccaacg aggaaatgta    1560

ctactgtctc ccgaggaggt cagtgaaaca cagggaacag agaaactgac aataacttac    1620

tcatcgtcaa tgatgtggga gattaatggt cctgaatcag tgttggtcaa tacctatcaa    1680

tggatcatca gaaactggga aactgttaaa attcagtggt cccagaaccc tacaatgcta    1740

tacaataaaa tggaatttga accatttcag tctttagtac ctaaggccat tagaggccaa    1800

tacagtgggt ttgtaagaac tctgttccaa caaatgaggg atgtgcttgg gacatttgat    1860

accgcacaga taataaaact tcttcccttc gcagccgctc caccaaagca aagtagaatg    1920

cagttctcct catttactgt gaatgtgagg ggatcaggaa tgagaatact tgtaaggggc    1980

aattctcctg tattcaacta taacaaggcc acgaagagac tcacagttct cggaaaggat    2040

gctggcactt taactgaaga cccagatgaa ggcacagctg gagtggagtc cgctgttctg    2100

aggggattcc tcattctggg caaagaagac aagagatatg ggccagcact aagcatcaat    2160

gaactgagca accttgcgaa aggagagaag gctaatgtgc taattgggca aggagacgtg    2220

gtgttggtaa tgaaacggaa acgggactct agcatactta ctgacagcca gacagcgacc    2280

aaaagaattc ggatggccat caattagtgt cgaatagttt aaaaacgacc ttgtttctac    2340

t                                                                    2341


<210> 26
<211> 759
<212> PRT
<213> Influenza A virus

<400> 26
Met Glu Arg Ile Lys Glu Leu Arg Asn Leu Met Ser Gln Ser Arg Thr 
1               5                   10                  15      
Arg Glu Ile Leu Thr Lys Thr Thr Val Asp His Met Ala Ile Ile Lys 
            20                  25                  30          
Lys Tyr Thr Ser Gly Arg Gln Glu Lys Asn Pro Ala Leu Arg Met Lys 
        35                  40                  45              
Trp Met Met Ala Met Lys Tyr Pro Ile Thr Ala Asp Lys Arg Ile Thr 
    50                  55                  60                  
Glu Met Ile Pro Glu Arg Asn Glu Gln Gly Gln Thr Leu Trp Ser Lys 
65                  70                  75                  80  
Met Asn Asp Ser Gly Ser Asp Arg Val Met Val Ser Pro Leu Ala Val 
                85                  90                  95      
Thr Trp Trp Asn Arg Asn Gly Pro Ile Thr Asn Thr Val His Tyr Pro 
            100                 105                 110         
Lys Ile Tyr Lys Thr Tyr Phe Glu Arg Val Glu Arg Leu Lys His Gly 
        115                 120                 125             
Thr Phe Gly Pro Val His Phe Arg Asn Gln Val Lys Ile Arg Arg Arg 
    130                 135                 140                 
Val Asp Ile Asn Pro Gly His Ala Asp Leu Ser Ala Lys Glu Ala Gln 
145                 150                 155                 160 
Asp Val Ile Met Glu Val Val Phe Pro Asn Glu Val Gly Ala Arg Ile 
                165                 170                 175     
Leu Thr Ser Glu Ser Gln Leu Thr Ile Thr Lys Glu Lys Lys Glu Glu 
            180                 185                 190         
Leu Gln Asp Cys Lys Ile Ser Pro Leu Met Val Ala Tyr Met Leu Glu 
        195                 200                 205             
Arg Glu Leu Val Arg Lys Thr Arg Phe Leu Pro Val Ala Gly Gly Thr 
    210                 215                 220                 
Ser Ser Val Tyr Ile Glu Val Leu His Leu Thr Gln Gly Thr Cys Trp 
225                 230                 235                 240 
Glu Gln Met Tyr Thr Pro Gly Gly Glu Val Arg Asn Asp Asp Val Asp 
                245                 250                 255     
Gln Ser Leu Ile Ile Ala Ala Arg Asn Ile Val Arg Arg Ala Ala Val 
            260                 265                 270         
Ser Ala Asp Pro Leu Ala Ser Leu Leu Glu Met Cys His Ser Thr Gln 
        275                 280                 285             
Ile Gly Gly Ile Arg Met Val Asp Ile Leu Arg Gln Asn Pro Thr Glu 
    290                 295                 300                 
Glu Gln Ala Val Asp Ile Cys Lys Ala Ala Met Gly Leu Arg Ile Ser 
305                 310                 315                 320 
Ser Ser Phe Ser Phe Gly Gly Phe Thr Phe Lys Arg Thr Ser Gly Ser 
                325                 330                 335     
Ser Val Lys Arg Glu Glu Glu Val Leu Thr Gly Asn Leu Gln Thr Leu 
            340                 345                 350         
Lys Ile Arg Val His Glu Gly Tyr Glu Glu Phe Thr Met Val Gly Arg 
        355                 360                 365             
Arg Ala Thr Ala Ile Leu Arg Lys Ala Thr Arg Arg Leu Ile Gln Leu 
    370                 375                 380                 
Ile Val Ser Gly Arg Asp Glu Gln Ser Ile Ala Glu Ala Ile Ile Val 
385                 390                 395                 400 
Ala Met Val Phe Ser Gln Glu Asp Cys Met Ile Lys Ala Val Arg Gly 
                405                 410                 415     
Asp Leu Asn Phe Val Asn Arg Ala Asn Gln Arg Leu Asn Pro Met His 
            420                 425                 430         
Gln Leu Leu Arg His Phe Gln Lys Asp Ala Lys Val Leu Phe Gln Asn 
        435                 440                 445             
Trp Gly Val Glu Pro Ile Asp Asn Val Met Gly Met Ile Gly Ile Leu 
    450                 455                 460                 
Pro Asp Met Thr Pro Ser Ile Glu Met Ser Met Arg Gly Val Arg Ile 
465                 470                 475                 480 
Ser Lys Met Gly Val Asp Glu Tyr Ser Ser Thr Glu Arg Val Val Val 
                485                 490                 495     
Ser Ile Asp Arg Phe Leu Arg Ile Arg Asp Gln Arg Gly Asn Val Leu 
            500                 505                 510         
Leu Ser Pro Glu Glu Val Ser Glu Thr Gln Gly Thr Glu Lys Leu Thr 
        515                 520                 525             
Ile Thr Tyr Ser Ser Ser Met Met Trp Glu Ile Asn Gly Pro Glu Ser 
    530                 535                 540                 
Val Leu Val Asn Thr Tyr Gln Trp Ile Ile Arg Asn Trp Glu Thr Val 
545                 550                 555                 560 
Lys Ile Gln Trp Ser Gln Asn Pro Thr Met Leu Tyr Asn Lys Met Glu 
                565                 570                 575     
Phe Glu Pro Phe Gln Ser Leu Val Pro Lys Ala Ile Arg Gly Gln Tyr 
            580                 585                 590         
Ser Gly Phe Val Arg Thr Leu Phe Gln Gln Met Arg Asp Val Leu Gly 
        595                 600                 605             
Thr Phe Asp Thr Ala Gln Ile Ile Lys Leu Leu Pro Phe Ala Ala Ala 
    610                 615                 620                 
Pro Pro Lys Gln Ser Arg Met Gln Phe Ser Ser Phe Thr Val Asn Val 
625                 630                 635                 640 
Arg Gly Ser Gly Met Arg Ile Leu Val Arg Gly Asn Ser Pro Val Phe 
                645                 650                 655     
Asn Tyr Asn Lys Ala Thr Lys Arg Leu Thr Val Leu Gly Lys Asp Ala 
            660                 665                 670         
Gly Thr Leu Thr Glu Asp Pro Asp Glu Gly Thr Ala Gly Val Glu Ser 
        675                 680                 685             
Ala Val Leu Arg Gly Phe Leu Ile Leu Gly Lys Glu Asp Lys Arg Tyr 
    690                 695                 700                 
Gly Pro Ala Leu Ser Ile Asn Glu Leu Ser Asn Leu Ala Lys Gly Glu 
705                 710                 715                 720 
Lys Ala Asn Val Leu Ile Gly Gln Gly Asp Val Val Leu Val Met Lys 
                725                 730                 735     
Arg Lys Arg Asp Ser Ser Ile Leu Thr Asp Ser Gln Thr Ala Thr Lys 
            740                 745                 750         
Arg Ile Arg Met Ala Ile Asn 
        755                 

<210> 27
<211> 2341
<212> DNA
<213> Artificial Sequence

<220> 
<223> PB2 K80R

<400> 27
agcgaaagca ggtcaattat attcaatatg gaaagaataa aagaactacg aaatctaatg      60

tcgcagtctc gcacccgcga gatactcaca aaaaccaccg tggaccatat ggccataatc     120

aagaagtaca catcaggaag acaggagaag aacccagcac ttaggatgaa atggatgatg     180

gcaatgaaat atccaattac agcagacaag aggataacgg aaatgattcc tgagagaaat     240

gagcaaggac aaactttatg gagtagaatg aatgattccg gatcagaccg agtgatggta     300

tcacctctgg ctgtgacatg gtggaatagg aatggaccaa taacaaatac agttcattat     360

ccaaaaatct acaaaactta ttttgaaaga gtcgaaaggc taaagcatgg aacctttggc     420

cctgtccatt ttagaaacca agtcaaaata cgtcggagag ttgacataaa tcctggtcat     480

gcagatctca gtgccaagga ggcacaggat gtaatcatgg aagttgtttt ccctaacgaa     540

gtgggagcca ggatactaac atcggaatcg caactaacga taaccaaaga gaagaaagaa     600

gaactccagg attgcaaaat ttctcctttg atggttgcat acatgttgga gagagaactg     660

gtccgcaaaa cgagattcct cccagtggct ggtggaacaa gcagtgtgta cattgaagtg     720

ttgcatttga ctcaaggaac atgctgggaa cagatgtata ctccaggagg ggaagtgagg     780

aatgatgatg ttgatcaaag cttgattatt gctgctagga acatagtgag aagagctgca     840

gtatcagcag atccactagc atctttattg gagatgtgcc acagcacaca gattggtgga     900

attaggatgg tagacatcct taggcagaac ccaacagaag agcaagccgt ggatatatgc     960

aaggctgcaa tgggactgag aattagctca tccttcagtt ttggtggatt cacatttaag    1020

agaacaagcg gatcatcagt caagagagag gaagaggtgc ttacgggcaa tcttcaaaca    1080

ttgaagataa gagtgcatga gggatatgaa gagttcacaa tggttgggag aagagcaaca    1140

gccatactca gaaaagcaac caggagattg attcagctga tagtgagtgg gagagacgaa    1200

cagtcgattg ccgaagcaat aattgtggcc atggtatttt cacaagagga ttgtatgata    1260

aaagcagtca gaggtgatct gaatttcgtc aatagggcaa atcaacgatt gaatcctatg    1320

catcaacttt taagacattt tcagaaggat gcgaaagtgc tttttcaaaa ttggggagtt    1380

gaacctatcg acaatgtgat gggaatgatt gggatattgc ccgacatgac tccaagcatc    1440

gagatgtcaa tgagaggagt gagaatcagc aaaatgggtg tagatgagta ctccagcacg    1500

gagagggtag tggtgagcat tgaccgtttt ttgagaatcc gggaccaacg aggaaatgta    1560

ctactgtctc ccgaggaggt cagtgaaaca cagggaacag agaaactgac aataacttac    1620

tcatcgtcaa tgatgtggga gattaatggt cctgaatcag tgttggtcaa tacctatcaa    1680

tggatcatca gaaactggga aactgttaaa attcagtggt cccagaaccc tacaatgcta    1740

tacaataaaa tggaatttga accatttcag tctttagtac ctaaggccat tagaggccaa    1800

tacagtgggt ttgtaagaac tctgttccaa caaatgaggg atgtgcttgg gacatttgat    1860

accgcacaga taataaaact tcttcccttc gcagccgctc caccaaagca aagtagaatg    1920

cagttctcct catttactgt gaatgtgagg ggatcaggaa tgagaatact tgtaaggggc    1980

aattctcctg tattcaacta taacaaggcc acgaagagac tcacagttct cggaaaggat    2040

gctggcactt taactgaaga cccagatgaa ggcacagctg gagtggagtc cgctgttctg    2100

aggggattcc tcattctggg caaagaagac aagagatatg ggccagcact aagcatcaat    2160

gaactgagca accttgcgaa aggagagaag gctaatgtgc taattgggca aggagacgtg    2220

gtgttggtaa tgaaacggaa acgggactct agcatactta ctgacagcca gacagcgacc    2280

aaaagaattc ggatggccat caattagtgt cgaatagttt aaaaacgacc ttgtttctac    2340

t                                                                    2341


<210> 28
<211> 759
<212> PRT
<213> Artificial Sequence

<220> 
<223> PB2 K80R

<400> 28
Met Glu Arg Ile Lys Glu Leu Arg Asn Leu Met Ser Gln Ser Arg Thr 
1               5                   10                  15      
Arg Glu Ile Leu Thr Lys Thr Thr Val Asp His Met Ala Ile Ile Lys 
            20                  25                  30          
Lys Tyr Thr Ser Gly Arg Gln Glu Lys Asn Pro Ala Leu Arg Met Lys 
        35                  40                  45              
Trp Met Met Ala Met Lys Tyr Pro Ile Thr Ala Asp Lys Arg Ile Thr 
    50                  55                  60                  
Glu Met Ile Pro Glu Arg Asn Glu Gln Gly Gln Thr Leu Trp Ser Arg 
65                  70                  75                  80  
Met Asn Asp Ser Gly Ser Asp Arg Val Met Val Ser Pro Leu Ala Val 
                85                  90                  95      
Thr Trp Trp Asn Arg Asn Gly Pro Ile Thr Asn Thr Val His Tyr Pro 
            100                 105                 110         
Lys Ile Tyr Lys Thr Tyr Phe Glu Arg Val Glu Arg Leu Lys His Gly 
        115                 120                 125             
Thr Phe Gly Pro Val His Phe Arg Asn Gln Val Lys Ile Arg Arg Arg 
    130                 135                 140                 
Val Asp Ile Asn Pro Gly His Ala Asp Leu Ser Ala Lys Glu Ala Gln 
145                 150                 155                 160 
Asp Val Ile Met Glu Val Val Phe Pro Asn Glu Val Gly Ala Arg Ile 
                165                 170                 175     
Leu Thr Ser Glu Ser Gln Leu Thr Ile Thr Lys Glu Lys Lys Glu Glu 
            180                 185                 190         
Leu Gln Asp Cys Lys Ile Ser Pro Leu Met Val Ala Tyr Met Leu Glu 
        195                 200                 205             
Arg Glu Leu Val Arg Lys Thr Arg Phe Leu Pro Val Ala Gly Gly Thr 
    210                 215                 220                 
Ser Ser Val Tyr Ile Glu Val Leu His Leu Thr Gln Gly Thr Cys Trp 
225                 230                 235                 240 
Glu Gln Met Tyr Thr Pro Gly Gly Glu Val Arg Asn Asp Asp Val Asp 
                245                 250                 255     
Gln Ser Leu Ile Ile Ala Ala Arg Asn Ile Val Arg Arg Ala Ala Val 
            260                 265                 270         
Ser Ala Asp Pro Leu Ala Ser Leu Leu Glu Met Cys His Ser Thr Gln 
        275                 280                 285             
Ile Gly Gly Ile Arg Met Val Asp Ile Leu Arg Gln Asn Pro Thr Glu 
    290                 295                 300                 
Glu Gln Ala Val Asp Ile Cys Lys Ala Ala Met Gly Leu Arg Ile Ser 
305                 310                 315                 320 
Ser Ser Phe Ser Phe Gly Gly Phe Thr Phe Lys Arg Thr Ser Gly Ser 
                325                 330                 335     
Ser Val Lys Arg Glu Glu Glu Val Leu Thr Gly Asn Leu Gln Thr Leu 
            340                 345                 350         
Lys Ile Arg Val His Glu Gly Tyr Glu Glu Phe Thr Met Val Gly Arg 
        355                 360                 365             
Arg Ala Thr Ala Ile Leu Arg Lys Ala Thr Arg Arg Leu Ile Gln Leu 
    370                 375                 380                 
Ile Val Ser Gly Arg Asp Glu Gln Ser Ile Ala Glu Ala Ile Ile Val 
385                 390                 395                 400 
Ala Met Val Phe Ser Gln Glu Asp Cys Met Ile Lys Ala Val Arg Gly 
                405                 410                 415     
Asp Leu Asn Phe Val Asn Arg Ala Asn Gln Arg Leu Asn Pro Met His 
            420                 425                 430         
Gln Leu Leu Arg His Phe Gln Lys Asp Ala Lys Val Leu Phe Gln Asn 
        435                 440                 445             
Trp Gly Val Glu Pro Ile Asp Asn Val Met Gly Met Ile Gly Ile Leu 
    450                 455                 460                 
Pro Asp Met Thr Pro Ser Ile Glu Met Ser Met Arg Gly Val Arg Ile 
465                 470                 475                 480 
Ser Lys Met Gly Val Asp Glu Tyr Ser Ser Thr Glu Arg Val Val Val 
                485                 490                 495     
Ser Ile Asp Arg Phe Leu Arg Ile Arg Asp Gln Arg Gly Asn Val Leu 
            500                 505                 510         
Leu Ser Pro Glu Glu Val Ser Glu Thr Gln Gly Thr Glu Lys Leu Thr 
        515                 520                 525             
Ile Thr Tyr Ser Ser Ser Met Met Trp Glu Ile Asn Gly Pro Glu Ser 
    530                 535                 540                 
Val Leu Val Asn Thr Tyr Gln Trp Ile Ile Arg Asn Trp Glu Thr Val 
545                 550                 555                 560 
Lys Ile Gln Trp Ser Gln Asn Pro Thr Met Leu Tyr Asn Lys Met Glu 
                565                 570                 575     
Phe Glu Pro Phe Gln Ser Leu Val Pro Lys Ala Ile Arg Gly Gln Tyr 
            580                 585                 590         
Ser Gly Phe Val Arg Thr Leu Phe Gln Gln Met Arg Asp Val Leu Gly 
        595                 600                 605             
Thr Phe Asp Thr Ala Gln Ile Ile Lys Leu Leu Pro Phe Ala Ala Ala 
    610                 615                 620                 
Pro Pro Lys Gln Ser Arg Met Gln Phe Ser Ser Phe Thr Val Asn Val 
625                 630                 635                 640 
Arg Gly Ser Gly Met Arg Ile Leu Val Arg Gly Asn Ser Pro Val Phe 
                645                 650                 655     
Asn Tyr Asn Lys Ala Thr Lys Arg Leu Thr Val Leu Gly Lys Asp Ala 
            660                 665                 670         
Gly Thr Leu Thr Glu Asp Pro Asp Glu Gly Thr Ala Gly Val Glu Ser 
        675                 680                 685             
Ala Val Leu Arg Gly Phe Leu Ile Leu Gly Lys Glu Asp Lys Arg Tyr 
    690                 695                 700                 
Gly Pro Ala Leu Ser Ile Asn Glu Leu Ser Asn Leu Ala Lys Gly Glu 
705                 710                 715                 720 
Lys Ala Asn Val Leu Ile Gly Gln Gly Asp Val Val Leu Val Met Lys 
                725                 730                 735     
Arg Lys Arg Asp Ser Ser Ile Leu Thr Asp Ser Gln Thr Ala Thr Lys 
            740                 745                 750         
Arg Ile Arg Met Ala Ile Asn 
        755                 

<210> 29
<211> 2341
<212> DNA
<213> Influenza A virus

<400> 29
agcgaaagca ggcaaaccat ttgaatggat gtcaatccga ctttactttt cttgaaaatt      60

ccagcgcaaa atgccataag caccacattc ccttatactg gagatcctcc atacagccat     120

ggaacaggaa caggatacac catggacaca gttaacagaa cacatcaata ttcagaaaaa     180

gggaaatgga caacaaacac agaaactggg gcgccccaac ttaacccgat tgatggacca     240

ctacctgagg ataatgagcc aagtggatat gcacaaacag actgtgtcct ggaagctatg     300

gctttccttg aggaatccca cccagggatc tttgaaaact cgtgccttga aacaatggaa     360

gtcgttcaac aaacaagagt ggacagactg acccaaggtc gtcagaccta tgattggaca     420

ttaaacagaa atcaaccagc cgcaactgca ttagccaaca ctatagaagt tttcagatcg     480

aatggtctaa cagctaatga gtcgggaagg ctaatagatt tcctcaagga tgtgatggaa     540

tcaatggata aagaggaaat agagataaca acacacttcc aaagaaaaag aagagtaaga     600

gacaacatga ccaagaaaat ggtcacacaa agaacaatag gaaagaaaaa gcagagagtg     660

aacaagagaa gctatctaat aagagcatta actttgaaca caatgaccaa agatgcagaa     720

agaggtaaat taaagagaag agctattgca acacccggga tgcaaatcag agggttcgtg     780

tactttgttg aaactctagc taggagcatt tgtgagaagc ttgaacagtc tggacttcca     840

gtaggaggta atgaaaagaa ggccaaactg gcaaatgttg tgagaaagat gatgactaat     900

tcacaagaca cagagctttc tttcacaatt actggagaca atactaagtg gaatgaaaat     960

caaaatcctc gaatgttcct ggcgatgatt acatatatca caaaaaatca acctgaatgg    1020

ttcagaaaca tcctgagcat cgcacccata atgttctcaa acaaaatggc gagactaggg    1080

aaaggataca tgttcgaaag taagagaatg aagctccgaa cacaaatacc agcagaaatg    1140

ctagcaagca ttgacctaaa gtatttcaat gaatcaacaa gaaagaaaat tgagaaaata    1200

aggcctcttc taatagatgg cacagcgtca ttgagccctg gaatgatgat gggcatgttc    1260

aacatgctaa gtacggtttt aggagtctca atactgaatc ttgggcaaaa gaaatacacc    1320

aaaacaacat actggtggga tgggcttcaa tcctctgatg attttgctct catagtgaat    1380

gcaccaaatc atgagggaat acaagcagga gtggatagat tctacagaac ctgcaagcta    1440

gtcggaatca atatgagcaa gaagaagtcc tatataaata ggacaggaac atttgaattc    1500

acaagctttt tttatcgcta tggatttgtg gccaatttta gcatggagct gcccagtttt    1560

ggagtgtctg ggattaatga atcagctgat atgagcattg gagtaacagt gataaagaac    1620

aacatgataa acaatgacct tggaccagca acagcccaga tggctcttca actgttcatc    1680

aaggactaca gatatacata tcggtgccac agaggagaca cacaaattca gacgaggaga    1740

tcatttgagc taaagaagct gtgggagcaa acccgatcaa aggcaggact attggtttca    1800

gatggaggac cgaacttata caatatccgg aatcttcaca tccctgaagt ctgcttaaag    1860

tgggagctaa tggatgaaga ctatcaggga agactttgta atcccctgaa tccatttgtc    1920

agccataaag agattgagtc tgtaaacaat gctgtggtaa tgccagctca tggtccagcc    1980

aagagcatgg aatatgacgc tgttgcaact acacactcct ggattcccaa gaggaaccgc    2040

tctattctca acacaagcca aaggggaatt cttgaggatg aacagatgta tcagaagtgc    2100

tgcaacctgt tcgagaaatt tttccccagt agttcataca ggagaccggt tggaatttcc    2160

agcatggtgg aggccatggt gtctagggcc cggattgatg ccagaattga cttcgagtct    2220

ggacggatta agaaagaaga gttctccgag atcatgaaga tctgttccac cattgaagag    2280

ctcagacggc aaaaacaatg aatttagctt gtccttcatg aaaaaatgcc ttgtttctac    2340

t                                                                    2341


<210> 30
<211> 758
<212> PRT
<213> Influenza A virus

<400> 30
Met Asp Val Asn Pro Thr Leu Leu Phe Leu Lys Ile Pro Ala Gln Asn 
1               5                   10                  15      
Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Asp Pro Pro Tyr Ser His 
            20                  25                  30          
Gly Thr Gly Thr Gly Tyr Thr Met Asp Thr Val Asn Arg Thr His Gln 
        35                  40                  45              
Tyr Ser Glu Lys Gly Lys Trp Thr Thr Asn Thr Glu Thr Gly Ala Pro 
    50                  55                  60                  
Gln Leu Asn Pro Ile Asp Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  
Gly Tyr Ala Gln Thr Asp Cys Val Leu Glu Ala Met Ala Phe Leu Glu 
                85                  90                  95      
Gly Ser His Pro Gly Ile Phe Glu Asn Ser Cys Leu Glu Thr Met Glu 
            100                 105                 110         
Val Val Gln Gln Thr Arg Val Asp Arg Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             
Tyr Asp Trp Thr Leu Asn Arg Asn Gln Pro Ala Ala Thr Ala Leu Ala 
    130                 135                 140                 
Asn Thr Ile Glu Val Phe Arg Ser Asn Gly Leu Thr Ala Asn Glu Ser 
145                 150                 155                 160 
Gly Arg Leu Ile Asp Phe Leu Lys Asp Val Met Glu Ser Met Asp Lys 
                165                 170                 175     
Glu Glu Ile Glu Ile Thr Thr His Phe Gln Arg Lys Arg Arg Val Arg 
            180                 185                 190         
Asp Asn Met Thr Lys Lys Met Val Thr Gln Arg Thr Ile Gly Lys Lys 
        195                 200                 205             
Lys Gln Arg Val Asn Lys Arg Ser Tyr Leu Ile Arg Ala Leu Thr Leu 
    210                 215                 220                 
Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 
Ile Ala Thr Pro Gly Met Gln Ile Arg Gly Phe Val Tyr Phe Val Glu 
                245                 250                 255     
Thr Leu Ala Arg Ser Ile Cys Glu Lys Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         
Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ala Asn Val Val Arg Lys 
        275                 280                 285             
Met Met Thr Asn Ser Gln Asp Thr Glu Leu Ser Phe Thr Ile Thr Gly 
    290                 295                 300                 
Asp Asn Thr Lys Trp Asn Glu Asn Gln Asn Pro Arg Met Phe Leu Ala 
305                 310                 315                 320 
Met Ile Thr Tyr Ile Thr Lys Asn Gln Pro Glu Trp Phe Arg Asn Ile 
                325                 330                 335     
Leu Ser Ile Ala Pro Ile Met Phe Ser Asn Lys Met Ala Arg Leu Gly 
            340                 345                 350         
Lys Gly Tyr Met Phe Glu Ser Lys Arg Met Lys Leu Arg Thr Gln Ile 
        355                 360                 365             
Pro Ala Glu Met Leu Ala Ser Ile Asp Leu Lys Tyr Phe Asn Glu Ser 
    370                 375                 380                 
Thr Arg Lys Lys Ile Glu Lys Ile Arg Pro Leu Leu Ile Asp Gly Thr 
385                 390                 395                 400 
Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu Ser 
                405                 410                 415     
Thr Val Leu Gly Val Ser Ile Leu Asn Leu Gly Gln Lys Lys Tyr Thr 
            420                 425                 430         
Lys Thr Thr Tyr Trp Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala 
        435                 440                 445             
Leu Ile Val Asn Ala Pro Asn His Glu Gly Ile Gln Ala Gly Val Asp 
    450                 455                 460                 
Arg Phe Tyr Arg Thr Cys Lys Leu Val Gly Ile Asn Met Ser Lys Lys 
465                 470                 475                 480 
Lys Ser Tyr Ile Asn Arg Thr Gly Thr Phe Glu Phe Thr Ser Phe Phe 
                485                 490                 495     
Tyr Arg Tyr Gly Phe Val Ala Asn Phe Ser Met Glu Leu Pro Ser Phe 
            500                 505                 510         
Gly Val Ser Gly Ile Asn Glu Ser Ala Asp Met Ser Ile Gly Val Thr 
        515                 520                 525             
Val Ile Lys Asn Asn Met Ile Asn Asn Asp Leu Gly Pro Ala Thr Ala 
    530                 535                 540                 
Gln Met Ala Leu Gln Leu Phe Ile Lys Asp Tyr Arg Tyr Thr Tyr Arg 
545                 550                 555                 560 
Cys His Arg Gly Asp Thr Gln Ile Gln Thr Arg Arg Ser Phe Glu Leu 
                565                 570                 575     
Lys Lys Leu Trp Glu Gln Thr Arg Ser Lys Ala Gly Leu Leu Val Ser 
            580                 585                 590         
Asp Gly Gly Pro Asn Leu Tyr Asn Ile Arg Asn Leu His Ile Pro Glu 
        595                 600                 605             
Val Cys Leu Lys Trp Glu Leu Met Asp Glu Asp Tyr Gln Gly Arg Leu 
    610                 615                 620                 
Cys Asn Pro Leu Asn Pro Phe Val Ser His Lys Glu Ile Glu Ser Val 
625                 630                 635                 640 
Asn Asn Ala Val Val Met Pro Ala His Gly Pro Ala Lys Ser Met Glu 
                645                 650                 655     
Tyr Asp Ala Val Ala Thr Thr His Ser Trp Ile Pro Lys Arg Asn Arg 
            660                 665                 670         
Ser Ile Leu Asn Thr Ser Gln Arg Gly Ile Leu Glu Asp Glu Gln Met 
        675                 680                 685             
Tyr Gln Lys Cys Cys Asn Leu Phe Glu Lys Phe Phe Pro Ser Ser Ser 
    690                 695                 700                 
Tyr Arg Arg Pro Val Gly Ile Ser Ser Met Val Glu Ala Met Val Ser 
705                 710                 715                 720 
Arg Ala Arg Ile Asp Ala Arg Ile Asp Phe Glu Ser Gly Arg Ile Lys 
                725                 730                 735     
Lys Glu Glu Phe Ser Glu Ile Met Lys Ile Cys Ser Thr Ile Glu Glu 
            740                 745                 750         
Leu Arg Arg Gln Lys Gln 
        755             

<210> 31
<211> 2341
<212> DNA
<213> Artificial Sequence

<220> 
<223> PB1 E97G S678N

<400> 31
agcgaaagca ggcaaaccat ttgaatggat gtcaatccga ctttactttt cttgaaaatt      60

ccagcgcaaa atgccataag caccacattc ccttatactg gagatcctcc atacagccat     120

ggaacaggaa caggatacac catggacaca gttaacagaa cacatcaata ttcagaaaaa     180

gggaaatgga caacaaacac agaaactggg gcgccccaac ttaacccgat tgatggacca     240

ctacctgagg ataatgagcc aagtggatat gcacaaacag actgtgtcct ggaagctatg     300

gctttccttg agggatccca cccagggatc tttgaaaact cgtgccttga aacaatggaa     360

gtcgttcaac aaacaagagt ggacagactg acccaaggtc gtcagaccta tgattggaca     420

ttaaacagaa atcaaccagc cgcaactgca ttagccaaca ctatagaagt tttcagatcg     480

aatggtctaa cagctaatga gtcgggaagg ctaatagatt tcctcaagga tgtgatggaa     540

tcaatggata aagaggaaat agagataaca acacacttcc aaagaaaaag aagagtaaga     600

gacaacatga ccaagaaaat ggtcacacaa agaacaatag gaaagaaaaa gcagagagtg     660

aacaagagaa gctatctaat aagagcatta actttgaaca caatgaccaa agatgcagaa     720

agaggtaaat taaagagaag agctattgca acacccggga tgcaaatcag agggttcgtg     780

tactttgttg aaactctagc taggagcatt tgtgagaagc ttgaacagtc tggacttcca     840

gtaggaggta atgaaaagaa ggccaaactg gcaaatgttg tgagaaagat gatgactaat     900

tcacaagaca cagagctttc tttcacaatt actggagaca atactaagtg gaatgaaaat     960

caaaatcctc gaatgttcct ggcgatgatt acatatatca caaaaaatca acctgaatgg    1020

ttcagaaaca tcctgagcat cgcacccata atgttctcaa acaaaatggc gagactaggg    1080

aaaggataca tgttcgaaag taagagaatg aagctccgaa cacaaatacc agcagaaatg    1140

ctagcaagca ttgacctaaa gtatttcaat gaatcaacaa gaaagaaaat tgagaaaata    1200

aggcctcttc taatagatgg cacagcgtca ttgagccctg gaatgatgat gggcatgttc    1260

aacatgctaa gtacggtttt aggagtctca atactgaatc ttgggcaaaa gaaatacacc    1320

aaaacaacat actggtggga tgggcttcaa tcctctgatg attttgctct catagtgaat    1380

gcaccaaatc atgagggaat acaagcagga gtggatagat tctacagaac ctgcaagcta    1440

gtcggaatca atatgagcaa gaagaagtcc tatataaata ggacaggaac atttgaattc    1500

acaagctttt tttatcgcta tggatttgtg gccaatttta gcatggagct gcccagtttt    1560

ggagtgtctg ggattaatga atcagctgat atgagcattg gagtaacagt gataaagaac    1620

aacatgataa acaatgacct tggaccagca acagcccaga tggctcttca actgttcatc    1680

aaggactaca gatatacata tcggtgccac agaggagaca cacaaattca gacgaggaga    1740

tcatttgagc taaagaagct gtgggagcaa acccgatcaa aggcaggact attggtttca    1800

gatggaggac cgaacttata caatatccgg aatcttcaca tccctgaagt ctgcttaaag    1860

tgggagctaa tggatgaaga ctatcaggga agactttgta atcccctgaa tccatttgtc    1920

agccataaag agattgagtc tgtaaacaat gctgtggtaa tgccagctca tggtccagcc    1980

aagagcatgg aatatgacgc tgttgcaact acacactcct ggattcccaa gaggaaccgc    2040

tctattctca acacaaacca aaggggaatt cttgaggatg aacagatgta tcagaagtgc    2100

tgcaacctgt tcgagaaatt tttccccagt agttcataca ggagaccggt tggaatttcc    2160

agcatggtgg aggccatggt gtctagggcc cggattgatg ccagaattga cttcgagtct    2220

ggacggatta agaaagaaga gttctccgag atcatgaaga tctgttccac cattgaagag    2280

ctcagacggc aaaaacaatg aatttagctt gtccttcatg aaaaaatgcc ttgtttctac    2340

t                                                                    2341


<210> 32
<211> 758
<212> PRT
<213> Artificial Sequence

<220> 
<223> PB1 E97G S678N

<400> 32
Met Asp Val Asn Pro Thr Leu Leu Phe Leu Lys Ile Pro Ala Gln Asn 
1               5                   10                  15      
Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Asp Pro Pro Tyr Ser His 
            20                  25                  30          
Gly Thr Gly Thr Gly Tyr Thr Met Asp Thr Val Asn Arg Thr His Gln 
        35                  40                  45              
Tyr Ser Glu Lys Gly Lys Trp Thr Thr Asn Thr Glu Thr Gly Ala Pro 
    50                  55                  60                  
Gln Leu Asn Pro Ile Asp Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  
Gly Tyr Ala Gln Thr Asp Cys Val Leu Glu Ala Met Ala Phe Leu Gly 
                85                  90                  95      
Gly Ser His Pro Gly Ile Phe Glu Asn Ser Cys Leu Glu Thr Met Glu 
            100                 105                 110         
Val Val Gln Gln Thr Arg Val Asp Arg Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             
Tyr Asp Trp Thr Leu Asn Arg Asn Gln Pro Ala Ala Thr Ala Leu Ala 
    130                 135                 140                 
Asn Thr Ile Glu Val Phe Arg Ser Asn Gly Leu Thr Ala Asn Glu Ser 
145                 150                 155                 160 
Gly Arg Leu Ile Asp Phe Leu Lys Asp Val Met Glu Ser Met Asp Lys 
                165                 170                 175     
Glu Glu Ile Glu Ile Thr Thr His Phe Gln Arg Lys Arg Arg Val Arg 
            180                 185                 190         
Asp Asn Met Thr Lys Lys Met Val Thr Gln Arg Thr Ile Gly Lys Lys 
        195                 200                 205             
Lys Gln Arg Val Asn Lys Arg Ser Tyr Leu Ile Arg Ala Leu Thr Leu 
    210                 215                 220                 
Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 
Ile Ala Thr Pro Gly Met Gln Ile Arg Gly Phe Val Tyr Phe Val Glu 
                245                 250                 255     
Thr Leu Ala Arg Ser Ile Cys Glu Lys Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         
Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ala Asn Val Val Arg Lys 
        275                 280                 285             
Met Met Thr Asn Ser Gln Asp Thr Glu Leu Ser Phe Thr Ile Thr Gly 
    290                 295                 300                 
Asp Asn Thr Lys Trp Asn Glu Asn Gln Asn Pro Arg Met Phe Leu Ala 
305                 310                 315                 320 
Met Ile Thr Tyr Ile Thr Lys Asn Gln Pro Glu Trp Phe Arg Asn Ile 
                325                 330                 335     
Leu Ser Ile Ala Pro Ile Met Phe Ser Asn Lys Met Ala Arg Leu Gly 
            340                 345                 350         
Lys Gly Tyr Met Phe Glu Ser Lys Arg Met Lys Leu Arg Thr Gln Ile 
        355                 360                 365             
Pro Ala Glu Met Leu Ala Ser Ile Asp Leu Lys Tyr Phe Asn Glu Ser 
    370                 375                 380                 
Thr Arg Lys Lys Ile Glu Lys Ile Arg Pro Leu Leu Ile Asp Gly Thr 
385                 390                 395                 400 
Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu Ser 
                405                 410                 415     
Thr Val Leu Gly Val Ser Ile Leu Asn Leu Gly Gln Lys Lys Tyr Thr 
            420                 425                 430         
Lys Thr Thr Tyr Trp Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala 
        435                 440                 445             
Leu Ile Val Asn Ala Pro Asn His Glu Gly Ile Gln Ala Gly Val Asp 
    450                 455                 460                 
Arg Phe Tyr Arg Thr Cys Lys Leu Val Gly Ile Asn Met Ser Lys Lys 
465                 470                 475                 480 
Lys Ser Tyr Ile Asn Arg Thr Gly Thr Phe Glu Phe Thr Ser Phe Phe 
                485                 490                 495     
Tyr Arg Tyr Gly Phe Val Ala Asn Phe Ser Met Glu Leu Pro Ser Phe 
            500                 505                 510         
Gly Val Ser Gly Ile Asn Glu Ser Ala Asp Met Ser Ile Gly Val Thr 
        515                 520                 525             
Val Ile Lys Asn Asn Met Ile Asn Asn Asp Leu Gly Pro Ala Thr Ala 
    530                 535                 540                 
Gln Met Ala Leu Gln Leu Phe Ile Lys Asp Tyr Arg Tyr Thr Tyr Arg 
545                 550                 555                 560 
Cys His Arg Gly Asp Thr Gln Ile Gln Thr Arg Arg Ser Phe Glu Leu 
                565                 570                 575     
Lys Lys Leu Trp Glu Gln Thr Arg Ser Lys Ala Gly Leu Leu Val Ser 
            580                 585                 590         
Asp Gly Gly Pro Asn Leu Tyr Asn Ile Arg Asn Leu His Ile Pro Glu 
        595                 600                 605             
Val Cys Leu Lys Trp Glu Leu Met Asp Glu Asp Tyr Gln Gly Arg Leu 
    610                 615                 620                 
Cys Asn Pro Leu Asn Pro Phe Val Ser His Lys Glu Ile Glu Ser Val 
625                 630                 635                 640 
Asn Asn Ala Val Val Met Pro Ala His Gly Pro Ala Lys Ser Met Glu 
                645                 650                 655     
Tyr Asp Ala Val Ala Thr Thr His Ser Trp Ile Pro Lys Arg Asn Arg 
            660                 665                 670         
Ser Ile Leu Asn Thr Asn Gln Arg Gly Ile Leu Glu Asp Glu Gln Met 
        675                 680                 685             
Tyr Gln Lys Cys Cys Asn Leu Phe Glu Lys Phe Phe Pro Ser Ser Ser 
    690                 695                 700                 
Tyr Arg Arg Pro Val Gly Ile Ser Ser Met Val Glu Ala Met Val Ser 
705                 710                 715                 720 
Arg Ala Arg Ile Asp Ala Arg Ile Asp Phe Glu Ser Gly Arg Ile Lys 
                725                 730                 735     
Lys Glu Glu Phe Ser Glu Ile Met Lys Ile Cys Ser Thr Ile Glu Glu 
            740                 745                 750         
Leu Arg Arg Gln Lys Gln 
        755             

<210> 33
<211> 442
<212> DNA
<213> Artificial Sequence

<220> 
<223> NS2 NS2 R76G

<400> 33
agcagaagca gaggatttgt ttagtcactg gcaaacagga aaaatggcgg acaatatgac      60

cacaacacaa attgagtgga ggatgaagaa gatggccatc ggatcctcaa ttcactcttc     120

gagcgtctta atgaaggaca ttcaaagcca attcgagcag ctgaaactgc ggtgggagtc     180

ttatcccaat ttggtcaaga gcaccgatta tcaccagaag agggagacaa ttagactggt     240

cacggaagaa ctttatcttt taagtaaagg aattgatgat aacatattgt tccacaaaac     300

agtaatagct aacagctcca taatagctga catggttgta tcattatcat tattagaaac     360

attgtatgaa atgaaggatg tggttgaagt gtacagcagg cagtgcttgt gaatttaaaa     420

taaaaatcct cttgttacta ct                                              442


<210> 34
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> NS2 NS2 R76G

<400> 34
Met Ala Asp Asn Met Thr Thr Thr Gln Ile Glu Trp Arg Met Lys Lys 
1               5                   10                  15      
Met Ala Ile Gly Ser Ser Ile His Ser Ser Ser Val Leu Met Lys Asp 
            20                  25                  30          
Ile Gln Ser Gln Phe Glu Gln Leu Lys Leu Arg Trp Glu Ser Tyr Pro 
        35                  40                  45              
Asn Leu Val Lys Ser Thr Asp Tyr His Gln Lys Arg Glu Thr Ile Arg 
    50                  55                  60                  
Leu Val Thr Glu Glu Leu Tyr Leu Leu Ser Lys Gly Ile Asp Asp Asn 
65                  70                  75                  80  
Ile Leu Phe His Lys Thr Val Ile Ala Asn Ser Ser Ile Ile Ala Asp 
                85                  90                  95      
Met Val Val Ser Leu Ser Leu Leu Glu Thr Leu Tyr Glu Met Lys Asp 
            100                 105                 110         
Val Val Glu Val Tyr Ser Arg 
        115                 

<210> 35
<211> 1716
<212> DNA
<213> Artificial Sequence

<220> 
<223> PB1 E97G

<400> 35
cacaaagaac aataggaaag aaaaagcaga gagtgaacaa gagaagctat ctaataagag      60

cattaacttt gaacacaatg accaaagatg cagaaagagg taaattaaag agaagagcta     120

ttgcaacacc cgggatgcaa atcagagggt tcgtgtactt tgttgaaact ctagctagga     180

gcatttgtga gaagcttgaa cagtctggac ttccagtagg aggtaatgaa aagaaggcca     240

aactggcaaa tgttgtgaga aagatgatga ctaattcaca agacacagag ctttctttca     300

caattactgg agacaatact aagtggaatg aaaatcaaaa tcctcgaatg ttcctggcga     360

tgattacata tatcacaaaa aatcaacctg aatggttcag aaacatcctg agcatcgcac     420

ccataatgtt ctcaaacaaa atggcgagac tagggaaagg atacatgttc gaaagtaaga     480

gaatgaagct ccgaacacaa ataccagcag aaatgctagc aagcattgac ctaaagtatt     540

tcaatgaatc aacaagaaag aaaattgaga aaataaggcc tcttctaata gatggcacag     600

cgtcattgag ccctggaatg atgatgggca tgttcaacat gctaagtacg gttttaggag     660

tctcaatact gaatcttggg caaaagaaat acaccaaaac aacatactgg tgggatgggc     720

ttcaatcctc tgatgatttt gctctcatag tgaatgcacc aaatcatgag ggaatacaag     780

caggagtgga tagattctac agaacctgca agctagtcgg aatcaatatg agcaagaaga     840

agtcctatat aaataggaca ggaacatttg aattcacaag ctttttttat cgctatggat     900

ttgtggccaa ttttagcatg gagctgccca gttttggagt gtctgggatt aatgaatcag     960

ctgatatgag cattggagta acagtgataa agaacaacat gataaacaat gaccttggac    1020

cagcaacagc ccagatggct cttcaactgt tcatcaagga ctacagatat acatatcggt    1080

gccacagagg agacacacaa attcagacga ggagatcatt tgagctaaag aagctgtggg    1140

agcaaacccg atcaaaggca ggactattgg tttcagatgg aggaccgaac ttatacaata    1200

tccggaatct tcacatccct gaagtctgct taaagtggga gctaatggat gaagactatc    1260

agggaagact ttgtaatccc ctgaatccat ttgtcagcca taaagagatt gagtctgtaa    1320

acaatgctgt ggtaatgcca gctcatggtc cagccaagag catggaatat gacgctgttg    1380

caactacaca ctcctggatt cccaagagga accgctctat tctcaacaca agccaaaggg    1440

gaattcttga ggatgaacag atgtatcaga agtgctgcaa cctgttcgag aaatttttcc    1500

ccagtagttc atacaggaga ccggttggaa tttccagcat ggtggaggcc atggtgtcta    1560

gggcccggat tgatgccaga attgacttcg agtctggacg gattaagaaa gaagagttct    1620

ccgagatcat gaagatctgt tccaccattg aagagctcag acggcaaaaa caatgaattt    1680

agcttgtcct tcatgaaaaa atgccttgtt tctact                              1716


<210> 36
<211> 2341
<212> DNA
<213> Artificial Sequence

<220> 
<223> PB1 S678N

<400> 36
agcgaaagca ggcaaaccat ttgaatggat gtcaatccga ctttactttt cttgaaaatt      60

ccagcgcaaa atgccataag caccacattc ccttatactg gagatcctcc atacagccat     120

ggaacaggaa caggatacac catggacaca gttaacagaa cacatcaata ttcagaaaaa     180

gggaaatgga caacaaacac agaaactggg gcgccccaac ttaacccgat tgatggacca     240

ctacctgagg ataatgagcc aagtggatat gcacaaacag actgtgtcct ggaagctatg     300

gctttccttg aggaatccca cccagggatc tttgaaaact cgtgccttga aacaatggaa     360

gtcgttcaac aaacaagagt ggacagactg acccaaggtc gtcagaccta tgattggaca     420

ttaaacagaa atcaaccagc cgcaactgca ttagccaaca ctatagaagt tttcagatcg     480

aatggtctaa cagctaatga gtcgggaagg ctaatagatt tcctcaagga tgtgatggaa     540

tcaatggata aagaggaaat agagataaca acacacttcc aaagaaaaag aagagtaaga     600

gacaacatga ccaagaaaat ggtcacacaa agaacaatag gaaagaaaaa gcagagagtg     660

aacaagagaa gctatctaat aagagcatta actttgaaca caatgaccaa agatgcagaa     720

agaggtaaat taaagagaag agctattgca acacccggga tgcaaatcag agggttcgtg     780

tactttgttg aaactctagc taggagcatt tgtgagaagc ttgaacagtc tggacttcca     840

gtaggaggta atgaaaagaa ggccaaactg gcaaatgttg tgagaaagat gatgactaat     900

tcacaagaca cagagctttc tttcacaatt actggagaca atactaagtg gaatgaaaat     960

caaaatcctc gaatgttcct ggcgatgatt acatatatca caaaaaatca acctgaatgg    1020

ttcagaaaca tcctgagcat cgcacccata atgttctcaa acaaaatggc gagactaggg    1080

aaaggataca tgttcgaaag taagagaatg aagctccgaa cacaaatacc agcagaaatg    1140

ctagcaagca ttgacctaaa gtatttcaat gaatcaacaa gaaagaaaat tgagaaaata    1200

aggcctcttc taatagatgg cacagcgtca ttgagccctg gaatgatgat gggcatgttc    1260

aacatgctaa gtacggtttt aggagtctca atactgaatc ttgggcaaaa gaaatacacc    1320

aaaacaacat actggtggga tgggcttcaa tcctctgatg attttgctct catagtgaat    1380

gcaccaaatc atgagggaat acaagcagga gtggatagat tctacagaac ctgcaagcta    1440

gtcggaatca atatgagcaa gaagaagtcc tatataaata ggacaggaac atttgaattc    1500

acaagctttt tttatcgcta tggatttgtg gccaatttta gcatggagct gcccagtttt    1560

ggagtgtctg ggattaatga atcagctgat atgagcattg gagtaacagt gataaagaac    1620

aacatgataa acaatgacct tggaccagca acagcccaga tggctcttca actgttcatc    1680

aaggactaca gatatacata tcggtgccac agaggagaca cacaaattca gacgaggaga    1740

tcatttgagc taaagaagct gtgggagcaa acccgatcaa aggcaggact attggtttca    1800

gatggaggac cgaacttata caatatccgg aatcttcaca tccctgaagt ctgcttaaag    1860

tgggagctaa tggatgaaga ctatcaggga agactttgta atcccctgaa tccatttgtc    1920

agccataaag agattgagtc tgtaaacaat gctgtggtaa tgccagctca tggtccagcc    1980

aagagcatgg aatatgacgc tgttgcaact acacactcct ggattcccaa gaggaaccgc    2040

tctattctca acacaaacca aaggggaatt cttgaggatg aacagatgta tcagaagtgc    2100

tgcaacctgt tcgagaaatt tttccccagt agttcataca ggagaccggt tggaatttcc    2160

agcatggtgg aggccatggt gtctagggcc cggattgatg ccagaattga cttcgagtct    2220

ggacggatta agaaagaaga gttctccgag atcatgaaga tctgttccac cattgaagag    2280

ctcagacggc aaaaacaatg aatttagctt gtccttcatg aaaaaatgcc ttgtttctac    2340

t                                                                    2341


<210> 37
<211> 758
<212> PRT
<213> Artificial Sequence

<220> 
<223> PB1 E97G

<400> 37
Met Asp Val Asn Pro Thr Leu Leu Phe Leu Lys Ile Pro Ala Gln Asn 
1               5                   10                  15      
Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Asp Pro Pro Tyr Ser His 
            20                  25                  30          
Gly Thr Gly Thr Gly Tyr Thr Met Asp Thr Val Asn Arg Thr His Gln 
        35                  40                  45              
Tyr Ser Glu Lys Gly Lys Trp Thr Thr Asn Thr Glu Thr Gly Ala Pro 
    50                  55                  60                  
Gln Leu Asn Pro Ile Asp Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  
Gly Tyr Ala Gln Thr Asp Cys Val Leu Glu Ala Met Ala Phe Leu Gly 
                85                  90                  95      
Gly Ser His Pro Gly Ile Phe Glu Asn Ser Cys Leu Glu Thr Met Glu 
            100                 105                 110         
Val Val Gln Gln Thr Arg Val Asp Arg Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             
Tyr Asp Trp Thr Leu Asn Arg Asn Gln Pro Ala Ala Thr Ala Leu Ala 
    130                 135                 140                 
Asn Thr Ile Glu Val Phe Arg Ser Asn Gly Leu Thr Ala Asn Glu Ser 
145                 150                 155                 160 
Gly Arg Leu Ile Asp Phe Leu Lys Asp Val Met Glu Ser Met Asp Lys 
                165                 170                 175     
Glu Glu Ile Glu Ile Thr Thr His Phe Gln Arg Lys Arg Arg Val Arg 
            180                 185                 190         
Asp Asn Met Thr Lys Lys Met Val Thr Gln Arg Thr Ile Gly Lys Lys 
        195                 200                 205             
Lys Gln Arg Val Asn Lys Arg Ser Tyr Leu Ile Arg Ala Leu Thr Leu 
    210                 215                 220                 
Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 
Ile Ala Thr Pro Gly Met Gln Ile Arg Gly Phe Val Tyr Phe Val Glu 
                245                 250                 255     
Thr Leu Ala Arg Ser Ile Cys Glu Lys Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         
Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ala Asn Val Val Arg Lys 
        275                 280                 285             
Met Met Thr Asn Ser Gln Asp Thr Glu Leu Ser Phe Thr Ile Thr Gly 
    290                 295                 300                 
Asp Asn Thr Lys Trp Asn Glu Asn Gln Asn Pro Arg Met Phe Leu Ala 
305                 310                 315                 320 
Met Ile Thr Tyr Ile Thr Lys Asn Gln Pro Glu Trp Phe Arg Asn Ile 
                325                 330                 335     
Leu Ser Ile Ala Pro Ile Met Phe Ser Asn Lys Met Ala Arg Leu Gly 
            340                 345                 350         
Lys Gly Tyr Met Phe Glu Ser Lys Arg Met Lys Leu Arg Thr Gln Ile 
        355                 360                 365             
Pro Ala Glu Met Leu Ala Ser Ile Asp Leu Lys Tyr Phe Asn Glu Ser 
    370                 375                 380                 
Thr Arg Lys Lys Ile Glu Lys Ile Arg Pro Leu Leu Ile Asp Gly Thr 
385                 390                 395                 400 
Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu Ser 
                405                 410                 415     
Thr Val Leu Gly Val Ser Ile Leu Asn Leu Gly Gln Lys Lys Tyr Thr 
            420                 425                 430         
Lys Thr Thr Tyr Trp Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala 
        435                 440                 445             
Leu Ile Val Asn Ala Pro Asn His Glu Gly Ile Gln Ala Gly Val Asp 
    450                 455                 460                 
Arg Phe Tyr Arg Thr Cys Lys Leu Val Gly Ile Asn Met Ser Lys Lys 
465                 470                 475                 480 
Lys Ser Tyr Ile Asn Arg Thr Gly Thr Phe Glu Phe Thr Ser Phe Phe 
                485                 490                 495     
Tyr Arg Tyr Gly Phe Val Ala Asn Phe Ser Met Glu Leu Pro Ser Phe 
            500                 505                 510         
Gly Val Ser Gly Ile Asn Glu Ser Ala Asp Met Ser Ile Gly Val Thr 
        515                 520                 525             
Val Ile Lys Asn Asn Met Ile Asn Asn Asp Leu Gly Pro Ala Thr Ala 
    530                 535                 540                 
Gln Met Ala Leu Gln Leu Phe Ile Lys Asp Tyr Arg Tyr Thr Tyr Arg 
545                 550                 555                 560 
Cys His Arg Gly Asp Thr Gln Ile Gln Thr Arg Arg Ser Phe Glu Leu 
                565                 570                 575     
Lys Lys Leu Trp Glu Gln Thr Arg Ser Lys Ala Gly Leu Leu Val Ser 
            580                 585                 590         
Asp Gly Gly Pro Asn Leu Tyr Asn Ile Arg Asn Leu His Ile Pro Glu 
        595                 600                 605             
Val Cys Leu Lys Trp Glu Leu Met Asp Glu Asp Tyr Gln Gly Arg Leu 
    610                 615                 620                 
Cys Asn Pro Leu Asn Pro Phe Val Ser His Lys Glu Ile Glu Ser Val 
625                 630                 635                 640 
Asn Asn Ala Val Val Met Pro Ala His Gly Pro Ala Lys Ser Met Glu 
                645                 650                 655     
Tyr Asp Ala Val Ala Thr Thr His Ser Trp Ile Pro Lys Arg Asn Arg 
            660                 665                 670         
Ser Ile Leu Asn Thr Ser Gln Arg Gly Ile Leu Glu Asp Glu Gln Met 
        675                 680                 685             
Tyr Gln Lys Cys Cys Asn Leu Phe Glu Lys Phe Phe Pro Ser Ser Ser 
    690                 695                 700                 
Tyr Arg Arg Pro Val Gly Ile Ser Ser Met Val Glu Ala Met Val Ser 
705                 710                 715                 720 
Arg Ala Arg Ile Asp Ala Arg Ile Asp Phe Glu Ser Gly Arg Ile Lys 
                725                 730                 735     
Lys Glu Glu Phe Ser Glu Ile Met Lys Ile Cys Ser Thr Ile Glu Glu 
            740                 745                 750         
Leu Arg Arg Gln Lys Gln 
        755             

<210> 38
<211> 758
<212> PRT
<213> Artificial Sequence

<220> 
<223> PB1 S678N

<400> 38
Met Asp Val Asn Pro Thr Leu Leu Phe Leu Lys Ile Pro Ala Gln Asn 
1               5                   10                  15      
Ala Ile Ser Thr Thr Phe Pro Tyr Thr Gly Asp Pro Pro Tyr Ser His 
            20                  25                  30          
Gly Thr Gly Thr Gly Tyr Thr Met Asp Thr Val Asn Arg Thr His Gln 
        35                  40                  45              
Tyr Ser Glu Lys Gly Lys Trp Thr Thr Asn Thr Glu Thr Gly Ala Pro 
    50                  55                  60                  
Gln Leu Asn Pro Ile Asp Gly Pro Leu Pro Glu Asp Asn Glu Pro Ser 
65                  70                  75                  80  
Gly Tyr Ala Gln Thr Asp Cys Val Leu Glu Ala Met Ala Phe Leu Glu 
                85                  90                  95      
Gly Ser His Pro Gly Ile Phe Glu Asn Ser Cys Leu Glu Thr Met Glu 
            100                 105                 110         
Val Val Gln Gln Thr Arg Val Asp Arg Leu Thr Gln Gly Arg Gln Thr 
        115                 120                 125             
Tyr Asp Trp Thr Leu Asn Arg Asn Gln Pro Ala Ala Thr Ala Leu Ala 
    130                 135                 140                 
Asn Thr Ile Glu Val Phe Arg Ser Asn Gly Leu Thr Ala Asn Glu Ser 
145                 150                 155                 160 
Gly Arg Leu Ile Asp Phe Leu Lys Asp Val Met Glu Ser Met Asp Lys 
                165                 170                 175     
Glu Glu Ile Glu Ile Thr Thr His Phe Gln Arg Lys Arg Arg Val Arg 
            180                 185                 190         
Asp Asn Met Thr Lys Lys Met Val Thr Gln Arg Thr Ile Gly Lys Lys 
        195                 200                 205             
Lys Gln Arg Val Asn Lys Arg Ser Tyr Leu Ile Arg Ala Leu Thr Leu 
    210                 215                 220                 
Asn Thr Met Thr Lys Asp Ala Glu Arg Gly Lys Leu Lys Arg Arg Ala 
225                 230                 235                 240 
Ile Ala Thr Pro Gly Met Gln Ile Arg Gly Phe Val Tyr Phe Val Glu 
                245                 250                 255     
Thr Leu Ala Arg Ser Ile Cys Glu Lys Leu Glu Gln Ser Gly Leu Pro 
            260                 265                 270         
Val Gly Gly Asn Glu Lys Lys Ala Lys Leu Ala Asn Val Val Arg Lys 
        275                 280                 285             
Met Met Thr Asn Ser Gln Asp Thr Glu Leu Ser Phe Thr Ile Thr Gly 
    290                 295                 300                 
Asp Asn Thr Lys Trp Asn Glu Asn Gln Asn Pro Arg Met Phe Leu Ala 
305                 310                 315                 320 
Met Ile Thr Tyr Ile Thr Lys Asn Gln Pro Glu Trp Phe Arg Asn Ile 
                325                 330                 335     
Leu Ser Ile Ala Pro Ile Met Phe Ser Asn Lys Met Ala Arg Leu Gly 
            340                 345                 350         
Lys Gly Tyr Met Phe Glu Ser Lys Arg Met Lys Leu Arg Thr Gln Ile 
        355                 360                 365             
Pro Ala Glu Met Leu Ala Ser Ile Asp Leu Lys Tyr Phe Asn Glu Ser 
    370                 375                 380                 
Thr Arg Lys Lys Ile Glu Lys Ile Arg Pro Leu Leu Ile Asp Gly Thr 
385                 390                 395                 400 
Ala Ser Leu Ser Pro Gly Met Met Met Gly Met Phe Asn Met Leu Ser 
                405                 410                 415     
Thr Val Leu Gly Val Ser Ile Leu Asn Leu Gly Gln Lys Lys Tyr Thr 
            420                 425                 430         
Lys Thr Thr Tyr Trp Trp Asp Gly Leu Gln Ser Ser Asp Asp Phe Ala 
        435                 440                 445             
Leu Ile Val Asn Ala Pro Asn His Glu Gly Ile Gln Ala Gly Val Asp 
    450                 455                 460                 
Arg Phe Tyr Arg Thr Cys Lys Leu Val Gly Ile Asn Met Ser Lys Lys 
465                 470                 475                 480 
Lys Ser Tyr Ile Asn Arg Thr Gly Thr Phe Glu Phe Thr Ser Phe Phe 
                485                 490                 495     
Tyr Arg Tyr Gly Phe Val Ala Asn Phe Ser Met Glu Leu Pro Ser Phe 
            500                 505                 510         
Gly Val Ser Gly Ile Asn Glu Ser Ala Asp Met Ser Ile Gly Val Thr 
        515                 520                 525             
Val Ile Lys Asn Asn Met Ile Asn Asn Asp Leu Gly Pro Ala Thr Ala 
    530                 535                 540                 
Gln Met Ala Leu Gln Leu Phe Ile Lys Asp Tyr Arg Tyr Thr Tyr Arg 
545                 550                 555                 560 
Cys His Arg Gly Asp Thr Gln Ile Gln Thr Arg Arg Ser Phe Glu Leu 
                565                 570                 575     
Lys Lys Leu Trp Glu Gln Thr Arg Ser Lys Ala Gly Leu Leu Val Ser 
            580                 585                 590         
Asp Gly Gly Pro Asn Leu Tyr Asn Ile Arg Asn Leu His Ile Pro Glu 
        595                 600                 605             
Val Cys Leu Lys Trp Glu Leu Met Asp Glu Asp Tyr Gln Gly Arg Leu 
    610                 615                 620                 
Cys Asn Pro Leu Asn Pro Phe Val Ser His Lys Glu Ile Glu Ser Val 
625                 630                 635                 640 
Asn Asn Ala Val Val Met Pro Ala His Gly Pro Ala Lys Ser Met Glu 
                645                 650                 655     
Tyr Asp Ala Val Ala Thr Thr His Ser Trp Ile Pro Lys Arg Asn Arg 
            660                 665                 670         
Ser Ile Leu Asn Thr Asn Gln Arg Gly Ile Leu Glu Asp Glu Gln Met 
        675                 680                 685             
Tyr Gln Lys Cys Cys Asn Leu Phe Glu Lys Phe Phe Pro Ser Ser Ser 
    690                 695                 700                 
Tyr Arg Arg Pro Val Gly Ile Ser Ser Met Val Glu Ala Met Val Ser 
705                 710                 715                 720 
Arg Ala Arg Ile Asp Ala Arg Ile Asp Phe Glu Ser Gly Arg Ile Lys 
                725                 730                 735     
Lys Glu Glu Phe Ser Glu Ile Met Lys Ile Cys Ser Thr Ile Glu Glu 
            740                 745                 750         
Leu Arg Arg Gln Lys Gln 
        755             

