                         SEQUENCE LISTING

<110>  Universitt Heidelberg
       Christian-Albrechts-Universitt zu Kiel
 
<120>  Compound decreasing the concentration of 2-hydroxy-glutarate

<130>  UH15719PC

<150>  EP19153343.9
<151>  2019-01-23

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  1395
<212>  DNA
<213>  Mus musculus

<400>  1
atgtggccga ccctgcgcta cgtaggcggt gtctgcggac tggcccggta ctgcgtggct       60

gggggcttcc tccgcgcaag tggaccggcg tccggggtgc ccgggctact gtgcgggggt      120

ggccgcagaa gctccagcac cagctctttt gatatagtca tcgttggagg tggaattgtg      180

ggccttgcct ctgccagaac gctcatcctg aaacatcctg gactttcgat tggtgtggtg      240

gaaaaggaga aagatttagc tcttcaccag actggacaca acagcggtgt catacacagt      300

ggtatttact ataaaccaga atctctgaag gctaaattgt gtgtagaagg cgcagccctc      360

atctatgagt actgcaacct caagggaatt ccctacaggc aatgtggcaa gctaatagta      420

gctgttgaac aagaagaaat tcccagactt caggccttgt atgagagagg cctgcagaat      480

ggagtcgaag gcctgaggct gatccagcag gaggatataa aaaagaagga gccgtattgc      540

aggggtctaa tggctattga ttgtccatac accggcattg tgaactacca acaggtagct      600

ttgtcatttg cccaggattt ccaagaagca ggtggctcta tcttgagaga ttttgaggta      660

aaaggtattg aaatagctaa agaaaactct tcaagaagta aagatggcat gaactatcca      720

atcgctgtca agaacagcaa gggaaaggag attcggtgtc gatatgttgt cacatgtgct      780

ggtctttact ctgaccgtat ttcagagttg agtggctgca atcctgaccc tcaaattgtc      840

ccattccggg gagattacct ggtcttaaag ccagaaaagg gctaccttgt aaaaggaaat      900

atttatccgg tcccagacag ccggtttcct ttccttggag ttcactttac gcccaggttg      960

gatggcacta tttggctagg gcctaatgca gtgcttgcct ttaaacggga aggttacaga     1020

ccctttgact tcgatgccag agatgttatg gaagtaattc tcaaaagcgg cttcattaac     1080

ctggtgttcc agcatttctc ttatggagtt aatgaaatgt ataaagcctg ttttctcagt     1140

gaaacagtga agcatcttca aaagttcatt cctgaaatca ccatcagcga tgtccttcga     1200

ggtcctgctg gagtacgggc ccaggccctg gacagagatg gaaatctggt agaggatttt     1260

gtgtttgacg gagggactgg cgagattgca gaccgcgtcc ttcatgtgag aaatgcgcct     1320

tcgcctgctg ccacttcctc cctggcaatt tctagaatga tagcagagga agcacagcaa     1380

aggtttaagt tatga                                                      1395


<210>  2
<211>  464
<212>  PRT
<213>  Mus musculus

<400>  2

Met Trp Pro Thr Leu Arg Tyr Val Gly Gly Val Cys Gly Leu Ala Arg 
1               5                   10                  15      


Tyr Cys Val Ala Gly Gly Phe Leu Arg Ala Ser Gly Pro Ala Ser Gly 
            20                  25                  30          


Val Pro Gly Leu Leu Cys Gly Gly Gly Arg Arg Ser Ser Ser Thr Ser 
        35                  40                  45              


Ser Phe Asp Ile Val Ile Val Gly Gly Gly Ile Val Gly Leu Ala Ser 
    50                  55                  60                  


Ala Arg Thr Leu Ile Leu Lys His Pro Gly Leu Ser Ile Gly Val Val 
65                  70                  75                  80  


Glu Lys Glu Lys Asp Leu Ala Leu His Gln Thr Gly His Asn Ser Gly 
                85                  90                  95      


Val Ile His Ser Gly Ile Tyr Tyr Lys Pro Glu Ser Leu Lys Ala Lys 
            100                 105                 110         


Leu Cys Val Glu Gly Ala Ala Leu Ile Tyr Glu Tyr Cys Asn Leu Lys 
        115                 120                 125             


Gly Ile Pro Tyr Arg Gln Cys Gly Lys Leu Ile Val Ala Val Glu Gln 
    130                 135                 140                 


Glu Glu Ile Pro Arg Leu Gln Ala Leu Tyr Glu Arg Gly Leu Gln Asn 
145                 150                 155                 160 


Gly Val Glu Gly Leu Arg Leu Ile Gln Gln Glu Asp Ile Lys Lys Lys 
                165                 170                 175     


Glu Pro Tyr Cys Arg Gly Leu Met Ala Ile Asp Cys Pro Tyr Thr Gly 
            180                 185                 190         


Ile Val Asn Tyr Gln Gln Val Ala Leu Ser Phe Ala Gln Asp Phe Gln 
        195                 200                 205             


Glu Ala Gly Gly Ser Ile Leu Arg Asp Phe Glu Val Lys Gly Ile Glu 
    210                 215                 220                 


Ile Ala Lys Glu Asn Ser Ser Arg Ser Lys Asp Gly Met Asn Tyr Pro 
225                 230                 235                 240 


Ile Ala Val Lys Asn Ser Lys Gly Lys Glu Ile Arg Cys Arg Tyr Val 
                245                 250                 255     


Val Thr Cys Ala Gly Leu Tyr Ser Asp Arg Ile Ser Glu Leu Ser Gly 
            260                 265                 270         


Cys Asn Pro Asp Pro Gln Ile Val Pro Phe Arg Gly Asp Tyr Leu Val 
        275                 280                 285             


Leu Lys Pro Glu Lys Gly Tyr Leu Val Lys Gly Asn Ile Tyr Pro Val 
    290                 295                 300                 


Pro Asp Ser Arg Phe Pro Phe Leu Gly Val His Phe Thr Pro Arg Leu 
305                 310                 315                 320 


Asp Gly Thr Ile Trp Leu Gly Pro Asn Ala Val Leu Ala Phe Lys Arg 
                325                 330                 335     


Glu Gly Tyr Arg Pro Phe Asp Phe Asp Ala Arg Asp Val Met Glu Val 
            340                 345                 350         


Ile Leu Lys Ser Gly Phe Ile Asn Leu Val Phe Gln His Phe Ser Tyr 
        355                 360                 365             


Gly Val Asn Glu Met Tyr Lys Ala Cys Phe Leu Ser Glu Thr Val Lys 
    370                 375                 380                 


His Leu Gln Lys Phe Ile Pro Glu Ile Thr Ile Ser Asp Val Leu Arg 
385                 390                 395                 400 


Gly Pro Ala Gly Val Arg Ala Gln Ala Leu Asp Arg Asp Gly Asn Leu 
                405                 410                 415     


Val Glu Asp Phe Val Phe Asp Gly Gly Thr Gly Glu Ile Ala Asp Arg 
            420                 425                 430         


Val Leu His Val Arg Asn Ala Pro Ser Pro Ala Ala Thr Ser Ser Leu 
        435                 440                 445             


Ala Ile Ser Arg Met Ile Ala Glu Glu Ala Gln Gln Arg Phe Lys Leu 
    450                 455                 460                 


<210>  3
<211>  1392
<212>  DNA
<213>  Homo sapiens

<400>  3
atggtgccag cgctgcgtta tttggttggt gcctgcggac gggcccgcgg gcttttcgcc       60

ggtggctccc ctggggcgtg cgggttcgcg tctgggaggc caagaccgct gtgtggaggt      120

agccgcagcg ccagcaccag ctcatttgat atagtcatcg ttggtggcgg aattgtgggg      180

cttgcctctg ccagagcact catcctgcga catccatcac tttctattgg tgttctggaa      240

aaggagaaag atttagctgt tcaccagact ggacataaca gtggtgtcat acatagtgga      300

atttattata aacctgagtc tctgaaagcc aaattatgtg tacaaggtgc agccctcctc      360

tatgagtact gtcagcaaaa gggaatttcc tacaagcagt gtggcaagct tatagtagct      420

gttgaacaag aagaaattcc cagacttcag gccctatatg agaaaggcct ccagaatggt      480

gtcccgggcc tgaggctgat ccagcaggag gatataaaaa agaaggagcc atattgtagg      540

ggtctaatgg ctattgattg tccacatact ggcattgtgg actatcggca ggtggctttg      600

tcatttgccc aggatttcca agaagcaggt ggctctgtct tgaccaattt tgaagtaaaa      660

ggtattgaaa tggctaaaga aagtccttca agaagtatag atggaatgca atatccaatt      720

gttataaaga atacaaaggg agaggaaatt cgatgtcagt atgttgtgac atgtgcagga      780

ctttactcag accgtatttc agagttgagt ggctgcactc ctgatcctcg aattgtacca      840

ttccggggag attacctgct tttgaagcca gaaaaatgtt atcttgtaaa aggaaatatt      900

tatccggtcc cagatagccg gtttcctttc ctaggagttc acttcacacc aaggatggat      960

ggcagtattt ggctagggcc taatgcagtt cttgccttta aacgagaggg ttacagaccc     1020

tttgacttca gtgccacaga tgttatggat ataattatca atagtggctt gattaaactg     1080

gcatcccaga atttttccta tggagttact gaaatgtata aagcatgttt tcttggtgca     1140

acagtgaagt atcttcaaaa attcatccct gaaattacta tcagtgatat acttaggggc     1200

ccagctggag taagagccca ggccctggat agagatggaa atctggtaga agattttgta     1260

tttgatgcag gagttgggga tattggaaat cgcattcttc atgtgagaaa tgcaccttct     1320

cctgctgcta cttcttccat tgcaatttct ggaatgattg cagatgaagt acaacaaaga     1380

tttgaattat aa                                                         1392


<210>  4
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Pro Ala Leu Arg Tyr Leu Val Gly Ala Cys Gly Arg Ala Arg 
1               5                   10                  15      


Gly Leu Phe Ala Gly Gly Ser Pro Gly Ala Cys Gly Phe Ala Ser Gly 
            20                  25                  30          


Arg Pro Arg Pro Leu Cys Gly Gly Ser Arg Ser Ala Ser Thr Ser Ser 
        35                  40                  45              


Phe Asp Ile Val Ile Val Gly Gly Gly Ile Val Gly Leu Ala Ser Ala 
    50                  55                  60                  


Arg Ala Leu Ile Leu Arg His Pro Ser Leu Ser Ile Gly Val Leu Glu 
65                  70                  75                  80  


Lys Glu Lys Asp Leu Ala Val His Gln Thr Gly His Asn Ser Gly Val 
                85                  90                  95      


Ile His Ser Gly Ile Tyr Tyr Lys Pro Glu Ser Leu Lys Ala Lys Leu 
            100                 105                 110         


Cys Val Gln Gly Ala Ala Leu Leu Tyr Glu Tyr Cys Gln Gln Lys Gly 
        115                 120                 125             


Ile Ser Tyr Lys Gln Cys Gly Lys Leu Ile Val Ala Val Glu Gln Glu 
    130                 135                 140                 


Glu Ile Pro Arg Leu Gln Ala Leu Tyr Glu Lys Gly Leu Gln Asn Gly 
145                 150                 155                 160 


Val Pro Gly Leu Arg Leu Ile Gln Gln Glu Asp Ile Lys Lys Lys Glu 
                165                 170                 175     


Pro Tyr Cys Arg Gly Leu Met Ala Ile Asp Cys Pro His Thr Gly Ile 
            180                 185                 190         


Val Asp Tyr Arg Gln Val Ala Leu Ser Phe Ala Gln Asp Phe Gln Glu 
        195                 200                 205             


Ala Gly Gly Ser Val Leu Thr Asn Phe Glu Val Lys Gly Ile Glu Met 
    210                 215                 220                 


Ala Lys Glu Ser Pro Ser Arg Ser Ile Asp Gly Met Gln Tyr Pro Ile 
225                 230                 235                 240 


Val Ile Lys Asn Thr Lys Gly Glu Glu Ile Arg Cys Gln Tyr Val Val 
                245                 250                 255     


Thr Cys Ala Gly Leu Tyr Ser Asp Arg Ile Ser Glu Leu Ser Gly Cys 
            260                 265                 270         


Thr Pro Asp Pro Arg Ile Val Pro Phe Arg Gly Asp Tyr Leu Leu Leu 
        275                 280                 285             


Lys Pro Glu Lys Cys Tyr Leu Val Lys Gly Asn Ile Tyr Pro Val Pro 
    290                 295                 300                 


Asp Ser Arg Phe Pro Phe Leu Gly Val His Phe Thr Pro Arg Met Asp 
305                 310                 315                 320 


Gly Ser Ile Trp Leu Gly Pro Asn Ala Val Leu Ala Phe Lys Arg Glu 
                325                 330                 335     


Gly Tyr Arg Pro Phe Asp Phe Ser Ala Thr Asp Val Met Asp Ile Ile 
            340                 345                 350         


Ile Asn Ser Gly Leu Ile Lys Leu Ala Ser Gln Asn Phe Ser Tyr Gly 
        355                 360                 365             


Val Thr Glu Met Tyr Lys Ala Cys Phe Leu Gly Ala Thr Val Lys Tyr 
    370                 375                 380                 


Leu Gln Lys Phe Ile Pro Glu Ile Thr Ile Ser Asp Ile Leu Arg Gly 
385                 390                 395                 400 


Pro Ala Gly Val Arg Ala Gln Ala Leu Asp Arg Asp Gly Asn Leu Val 
                405                 410                 415     


Glu Asp Phe Val Phe Asp Ala Gly Val Gly Asp Ile Gly Asn Arg Ile 
            420                 425                 430         


Leu His Val Arg Asn Ala Pro Ser Pro Ala Ala Thr Ser Ser Ile Ala 
        435                 440                 445             


Ile Ser Gly Met Ile Ala Asp Glu Val Gln Gln Arg Phe Glu Leu 
    450                 455                 460             


<210>  5
<211>  6980
<212>  DNA
<213>  Artificial

<220>
<223>  pSSV9-CMV-MLC1500-L2HGDH

<400>  5
tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc       60

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga gagggagtgg      120

ccaactccat cactaggggt tccttgtagt taatgattaa cccgccatgc tacttatcta      180

cgtagccatg ctctagagca agatcgaatt cggtaccgcg gtggcggccg cttcgagctc      240

gcccgacatt gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat      300

agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg      360

cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata      420

gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta      480

catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc      540

gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca gtacatctac      600

gtattagtca tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga      660

tagcggtttg actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg      720

ttttggcacc aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccatgcggc      780

cgctctagct agccttgaac tcactatgta ggcaagcatg accatgaact tctgatcctc      840

cttcctcagt gtcctgggat aacaggtgtg tgtcactccc tacccttcta atagcaatat      900

gtggccacat gtttgtgccc cacaggttga gaccatcttg acctgaggaa gaaatagcta      960

acactcacct cctgaaggtt gcctggatct cgtctttgtc tttccagcac tcaggagtgg     1020

gggggtcaga agtgcaaagt cagcccctgc tacataatga gttcaaggct cgcctgggct     1080

acatgagacc atgcctcaaa aagaaaagga attggtatag tgacatactc tggtcctccc     1140

agtacttagg gacacagagg ccactccacc accatctcca gcagctggcc tgcctccccg     1200

agcctcgttt atttcatatc aatgagatgg ggacccaact gctaaggtga ccttgcaccc     1260

acggggtgac tggagacttg agagtggagg gtttatcatt tctccagtcg gtcagcaagt     1320

ggtcgccgcc aagaaggttt tgagttcaaa gtagaagatg ggacagggag agaccagcga     1380

gaagacccca ccctggagct gactgtccct gtgcggctgg gtggggacac aaagcagaga     1440

agcagaggca gagaacaagg gtgggtgaca tttgagcaag gatgggggtg tgccagaggc     1500

tgcccaagat gcataggtgc aaaggccctg aggttcgagg atgcctggat ccggaatcaa     1560

agctcaggct cctccctctt cctcctcctc ctctgccccc tcctcctcct ctgccccctc     1620

ttcctcctct gccccctctt cttcctcctc ctcttcctcc tcccctcctc atctacctcc     1680

ttctcctcct cctccccctc ctcttcctcc tctgccccct cttcctcctc ctcctcttcc     1740

tcctcctctt cctcctcccc tcctcatcta cctccttctc ctcctcctcc ccctcctctt     1800

cctcctctgc cccctcttcc tcctctgccc ctcttcctcc tcctcctctt cctcctctgc     1860

cccctcctcc ccctcctctt cctcttcctc ctcccctcct catctacctc cttctcttcc     1920

tcctcttctt cctcctcttt ctcctcctcc tccctctcct cttcctcctc ctcttctttc     1980

tcctcctcct cttcctcccc ctccccttcc tgggttactt ttccccatta gacaatggca     2040

ggacccagag cacagagcat cgttcccagg ccaggcccca gccactgtct ctttaacctt     2100

gaaggcattt ttgggtctca cgtgtccacc caggcgggtg tcggactttg aacggctctt     2160

acttcagaag aacggcatgg ggtggggggg cttaggtggc ctctgcctca cctacaactg     2220

ccaaaagtgg tcatggggtt atttttaacc ccagggaaga ggtatttatt gttccacagc     2280

aggggccggc cagcaggctc cttgaatttc gaggaactga aaaaccagaa agttaactgg     2340

taagtttagt ctttttgtct tttatttcag gtcccggatc cggtggtggt gcaaatcaaa     2400

gaactgctcc tcagtggatg ttgcctttac ttctaggcct gtacggaagt gttacttctg     2460

ctctaaaagc tgcggaattg tacccgcggc cgcccccaat tcgagctcgc ccggggatcc     2520

tctagcgcca ccgtggaggg aggggaggtg gcgcaggcca tgtggccgac cctgcgctac     2580

gtaggcggtg tctgcggact ggcccggtac tgcgtggctg ggggcttcct ccgcgcaagt     2640

ggaccggcgt ccggggtgcc cgggctactg tgcgggggtg gccgcagaag ctccagcacc     2700

agctcttttg atatagtcat cgttggaggt ggaattgtgg gccttgcctc tgccagaacg     2760

ctcatcctga aacatcctgg actttcgatt ggtgtggtgg aaaaggagaa agatttagct     2820

cttcaccaga ctggacacaa cagcggtgtc atacacagtg gtatttacta taaaccagaa     2880

tctctgaagg ctaaattgtg tgtagaaggc gcagccctca tctatgagta ctgcaacctc     2940

aagggaattc cctacaggca atgtggcaag ctaatagtag ctgttgaaca agaagaaatt     3000

cccagacttc aggccttgta tgagagaggc ctgcagaatg gagtcgaagg cctgaggctg     3060

atccagcagg aggatataaa aaagaaggag ccgtattgca ggggtctaat ggctattgat     3120

tgtccataca ccggcattgt gaactaccaa caggtagctt tgtcatttgc ccaggatttc     3180

caagaagcag gtggctctat cttgagagat tttgaggtaa aaggtattga aatagctaaa     3240

gaaaactctt caagaagtaa agatggcatg aactatccaa tcgctgtcaa gaacagcaag     3300

ggaaaggaga ttcggtgtcg atatgttgtc acatgtgctg gtctttactc tgaccgtatt     3360

tcagagttga gtggctgcaa tcctgaccct caaattgtcc cattccgggg agattacctg     3420

gtcttaaagc cagaaaaggg ctaccttgta aaaggaaata tttatccggt cccagacagc     3480

cggtttcctt tccttggagt tcactttacg cccaggttgg atggcactat ttggctaggg     3540

cctaatgcag tgcttgcctt taaacgggaa ggttacagac cctttgactt cgatgccaga     3600

gatgttatgg aagtaattct caaaagcggc ttcattaacc tggtgttcca gcatttctct     3660

tatggagtta atgaaatgta taaagcctgt tttctcagtg aaacagtgaa gcatcttcaa     3720

aagttcattc ctgaaatcac catcagcgat gtccttcgag gtcctgctgg agtacgggcc     3780

caggccctgg acagagatgg aaatctggta gaggattttg tgtttgacgg agggactggc     3840

gagattgcag accgcgtcct tcatgtgaga aatgcgcctt cgcctgctgc cacttcctcc     3900

ctggcaattt ctagaatgat agcagaggaa gcacagcaaa ggtttaagtt atgagctaga     3960

gtcggggcgg ccggccgctt cgagcagaca tgataagata cattgatgag tttggacaaa     4020

ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt     4080

tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta     4140

tgtttcaggt tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat     4200

gtggtaaaat cgatgctagc ctagtaataa accggacatt cgaaaggctg cggtcgaact     4260

ctagttgctc tagagcatgg ctacgtagat aagtagcatg gcgggttaat cattaactac     4320

aaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag     4380

gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag     4440

cgagcgcgca gagagggagt ggccagctgc attaatgaat cggccaacgc gcggggagag     4500

gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg cgctcggtcg     4560

ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat     4620

caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta     4680

aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa     4740

atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc     4800

cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt     4860

ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca     4920

gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg     4980

accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat     5040

cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta     5100

cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta tttggtatct     5160

gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac     5220

aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa     5280

aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa     5340

actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt     5400

taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca     5460

gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca     5520

tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc     5580

ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa     5640

accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc     5700

agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca     5760

acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat     5820

tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag     5880

cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac     5940

tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt     6000

ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt     6060

gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc     6120

tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat     6180

ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca     6240

gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga     6300

cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg     6360

gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg     6420

ttccgcgcac atttccccga aaagtgccac ctaaattgta agcgttaata ttttgttaaa     6480

attcgcgtta aatttttgtt aaatcagctc attttttaac caataggccg aaatcggcaa     6540

aatcccttat aaatcaaaag aatagaccga gatagggttg agtgttgttc cagtttggaa     6600

caagagtcca ctattaaaga acgtggactc caacgtcaaa gggcgaaaaa ccgtctatca     6660

gggcgatggc ccactacgtg aaccatcacc ctaatcaagt tttttggggt cgaggtgccg     6720

taaagcacta aatcggaacc ctaaagggag cccccgattt agagcttgac ggggaaagcc     6780

ggcgaacgtg gcgagaaagg aagggaagaa agcgaaagga gcgggcgcta gggcgctggc     6840

aagtgtagcg gtcacgctgc gcgtaaccac cacacccgcc gcgcttaatg cgccgctaca     6900

gggcgcgtcc cattcgccat tcaggctgcg caactgttgg gaagggcgat cggtgcgggc     6960

ctcttcgcta ttacgccagc                                                 6980


<210>  6
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  GAPDH for

<400>  6
atgttccagt atgactccac tcacg                                             25


<210>  7
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  GAPDH rev

<400>  7
gaagacacca gtagactcca cgaca                                             25


<210>  8
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ANP for

<400>  8
acctgctaga ccacctggag gag                                               23


<210>  9
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  ANP rev

<400>  9
ccttggctgt tatcttcggt accgg                                             25


<210>  10
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  beta-MHC for

<400>  10
tgcaaaggct ccaggtctga gggc                                              24


<210>  11
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  beta-MHC rev

<400>  11
gccaacacca acctgtccaa gttc                                              24


<210>  12
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  RCAN1 for

<400>  12
gttggctgga aacaagtag                                                    19


<210>  13
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  RCAN1 rev

<400>  13
ggtctcttca ttctctcc                                                     18


<210>  14
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Col3 for

<400>  14
tggcccagct ggtgacaagg                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Col3 rev

<400>  15
cagcagggcc ctttcctccc                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  L2HGDH for

<400>  16
agggaaagga gattcggtgt                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  L2HGDH rev

<400>  17
gggcgtaaag tgaactccaa                                                   20


<210>  18
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  NheI-L2HGDH for

<400>  18
tcagtcgcta gcgccaccgt ggagggaggg ga                                     32


<210>  19
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  NheI-L2HGDH rev

<400>  19
tcagtcgcta gccctctgcc actcataac                                         29


