                         SEQUENCE LISTING

<110>  Koninklijke Nederlandse Akademie van Wetenschappen
 
<120>  TFAP2 inhibition for treating cardiac disease involving 
       fibro-fatty replacement.

<130>  P6081085PCT

<150>  EP19153135.9
<151>  2019-01-22

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  1314
<212>  DNA
<213>  Homo sapiens

<400>  1
atgctttgga aattgacgga taatatcaag tacgaggact gcgaggaccg tcacgacggc       60

accagcaacg ggacggcacg gttgccccag ctgggcactg taggtcaatc tccctacacg      120

agcgccccgc cgctgtccca cacccccaat gccgacttcc agcccccata cttcccccca      180

ccctaccagc ctatctaccc ccagtcgcaa gatccttact cccacgtcaa cgacccctac      240

agcctgaacc ccctgcacgc ccagccgcag ccgcagcacc caggctggcc cggccagagg      300

cagagccagg agtctgggct cctgcacacg caccgggggc tgcctcacca gctgtcgggc      360

ctggatcctc gcagggacta caggcggcac gaggacctcc tgcacggccc acacgcgctc      420

agctcaggac tcggagacct ctcgatccac tccttacctc acgccatcga ggaggtcccg      480

catgtagaag acccgggtat taacatccca gatcaaactg taattaagaa aggccccgtg      540

tccctgtcca agtccaacag caatgccgtc tccgccatcc ctattaacaa ggacaacctc      600

ttcggcggcg tggtgaaccc caacgaagtc ttctgttcag ttccgggtcg cctctcgctc      660

ctcagctcca cctcgaagta caaggtcacg gtggcggaag tgcagcggcg gctctcacca      720

cccgagtgtc tcaacgcgtc gctgctgggc ggagtgctcc ggagggcgaa gtctaaaaat      780

ggaggaagat ctttaagaga aaaactggac aaaataggat taaatctgcc tgcagggaga      840

cgtaaagctg ccaacgttac cctgctcaca tcactagtag agggagaagc tgtccaccta      900

gccagggact ttgggtacgt gtgcgaaacc gaatttcctg ccaaagcagt agctgaattt      960

ctcaaccgac aacattccga tcccaatgag caagtgacaa gaaaaaacat gctcctggct     1020

acaaaacaga tatgcaaaga gttcaccgac ctgctggctc aggaccgatc tcccctgggg     1080

aactcacggc ccaaccccat cctggagccc ggcatccaga gctgcttgac ccacttcaac     1140

ctcatctccc acggcttcgg cagccccgcg gtgtgtgccg cggtcacggc cctgcagaac     1200

tatctcaccg aggccctcaa ggccatggac aaaatgtacc tcagcaacaa ccccaacagc     1260

cacacggaca acaacgccaa aagcagtgac aaagaggaga agcacagaaa gtga           1314


<210>  2
<211>  1296
<212>  DNA
<213>  Homo sapiens

<400>  2
atgttagttc acagtttttc agccatggac cgtcacgacg gcaccagcaa cgggacggca       60

cggttgcccc agctgggcac tgtaggtcaa tctccctaca cgagcgcccc gccgctgtcc      120

cacaccccca atgccgactt ccagccccca tacttccccc caccctacca gcctatctac      180

ccccagtcgc aagatcctta ctcccacgtc aacgacccct acagcctgaa ccccctgcac      240

gcccagccgc agccgcagca cccaggctgg cccggccaga ggcagagcca ggagtctggg      300

ctcctgcaca cgcaccgggg gctgcctcac cagctgtcgg gcctggatcc tcgcagggac      360

tacaggcggc acgaggacct cctgcacggc ccacacgcgc tcagctcagg actcggagac      420

ctctcgatcc actccttacc tcacgccatc gaggaggtcc cgcatgtaga agacccgggt      480

attaacatcc cagatcaaac tgtaattaag aaaggccccg tgtccctgtc caagtccaac      540

agcaatgccg tctccgccat ccctattaac aaggacaacc tcttcggcgg cgtggtgaac      600

cccaacgaag tcttctgttc agttccgggt cgcctctcgc tcctcagctc cacctcgaag      660

tacaaggtca cggtggcgga agtgcagcgg cggctctcac cacccgagtg tctcaacgcg      720

tcgctgctgg gcggagtgct ccggagggcg aagtctaaaa atggaggaag atctttaaga      780

gaaaaactgg acaaaatagg attaaatctg cctgcaggga gacgtaaagc tgccaacgtt      840

accctgctca catcactagt agagggagaa gctgtccacc tagccaggga ctttgggtac      900

gtgtgcgaaa ccgaatttcc tgccaaagca gtagctgaat ttctcaaccg acaacattcc      960

gatcccaatg agcaagtgac aagaaaaaac atgctcctgg ctacaaaaca gatatgcaaa     1020

gagttcaccg acctgctggc tcaggaccga tctcccctgg ggaactcacg gcccaacccc     1080

atcctggagc ccggcatcca gagctgcttg acccacttca acctcatctc ccacggcttc     1140

ggcagccccg cggtgtgtgc cgcggtcacg gccctgcaga actatctcac cgaggccctc     1200

aaggccatgg acaaaatgta cctcagcaac aaccccaaca gccacacgga caacaacgcc     1260

aaaagcagtg acaaagagga gaagcacaga aagtga                               1296


<210>  3
<211>  1302
<212>  DNA
<213>  Homo sapiens

<400>  3
atgtccatac ttgccaaaat gggggactgg caggaccgtc acgacggcac cagcaacggg       60

acggcacggt tgccccagct gggcactgta ggtcaatctc cctacacgag cgccccgccg      120

ctgtcccaca cccccaatgc cgacttccag cccccatact tccccccacc ctaccagcct      180

atctaccccc agtcgcaaga tccttactcc cacgtcaacg acccctacag cctgaacccc      240

ctgcacgccc agccgcagcc gcagcaccca ggctggcccg gccagaggca gagccaggag      300

tctgggctcc tgcacacgca ccgggggctg cctcaccagc tgtcgggcct ggatcctcgc      360

agggactaca ggcggcacga ggacctcctg cacggcccac acgcgctcag ctcaggactc      420

ggagacctct cgatccactc cttacctcac gccatcgagg aggtcccgca tgtagaagac      480

ccgggtatta acatcccaga tcaaactgta attaagaaag gccccgtgtc cctgtccaag      540

tccaacagca atgccgtctc cgccatccct attaacaagg acaacctctt cggcggcgtg      600

gtgaacccca acgaagtctt ctgttcagtt ccgggtcgcc tctcgctcct cagctccacc      660

tcgaagtaca aggtcacggt ggcggaagtg cagcggcggc tctcaccacc cgagtgtctc      720

aacgcgtcgc tgctgggcgg agtgctccgg agggcgaagt ctaaaaatgg aggaagatct      780

ttaagagaaa aactggacaa aataggatta aatctgcctg cagggagacg taaagctgcc      840

aacgttaccc tgctcacatc actagtagag ggagaagctg tccacctagc cagggacttt      900

gggtacgtgt gcgaaaccga atttcctgcc aaagcagtag ctgaatttct caaccgacaa      960

cattccgatc ccaatgagca agtgacaaga aaaaacatgc tcctggctac aaaacagata     1020

tgcaaagagt tcaccgacct gctggctcag gaccgatctc ccctggggaa ctcacggccc     1080

aaccccatcc tggagcccgg catccagagc tgcttgaccc acttcaacct catctcccac     1140

ggcttcggca gccccgcggt gtgtgccgcg gtcacggccc tgcagaacta tctcaccgag     1200

gccctcaagg ccatggacaa aatgtacctc agcaacaacc ccaacagcca cacggacaac     1260

aacgccaaaa gcagtgacaa agaggagaag cacagaaagt ga                        1302


<210>  4
<211>  1383
<212>  DNA
<213>  Homo sapiens

<400>  4
atgcactcac ctcctagaga ccaggctgcc atcatgctct ggaagcttgt ggagaatgtc       60

aagtacgaag atatctatga ggaccggcac gatggtgtcc cgagccacag ctcgcggctc      120

tcccagctgg gctcggtgtc ccaaggaccc tactcgagcg ccccgccgct gtcccacacc      180

ccgtcgtcgg acttccagcc gccctacttc ccacccccct accagccgct cccctaccac      240

cagagccagg acccctactc ccacgtcaac gacccctact ccctgaaccc actgcaccag      300

ccccagcaac atccctgggg gcaacggcag cggcaagaag tgggttcgga agccggctct      360

ctcctgcccc agcctcgggc cgccttgccc cagctctcgg gccttgaccc ccggagggac      420

taccactcgg tccgccggcc ggacgtgctg ctgcattcgg cgcaccacgg cctggacgcg      480

ggcatgggtg acagcctctc gctgcacggc ctcggccatc ccggaatgga agacgtccag      540

tcagttgaag atgccaataa cagcggcatg aatctattgg accagtctgt cattaaaaaa      600

gttccagttc ctcccaaatc ggtgacttct ctaatgatga ataaagacgg cttcctggga      660

ggcatgtctg tcaacaccgg cgaggtgttt tgctccgtcc caggccgttt gtctctgctc      720

agttcaactt cgaagtacaa agtaactgtg ggagaagttc agagacggct gtcgccccct      780

gaatgcctca atgcatctct cctcggcgga gtcctcagaa gagccaaatc gaaaaatggg      840

gggagatctt tgcgagaaag gctagaaaaa atcggtttga atttacccgc gggcaggcgc      900

aaagcagcaa atgtcacgtt actcacctcc ctggtggaag gagaagctgt tcacttagct      960

agggattttg ggtacatttg cgaaacggag tttcccgcca aagccgtctc tgagtatttg     1020

aaccggcagc acacagaccc gagtgacctg cactcccgaa agaatatgct gttggccacc     1080

aagcaacttt gtaaagaatt tacggatcta ctggcgcagg accggacacc gatagggaac     1140

agccgaccca gccccatcct ggagccgggg atccagagct gcctcacgca cttcagcctc     1200

atcacgcacg gcttcggcgc cccggccatt tgcgccgcgc tcacggccct gcagaactat     1260

ctcaccgagg cgctcaaagg catggacaag atgttcttga acaacaccac cactaacagg     1320

cacacgtctg gggaaggccc aggtagtaaa actggcgaca aggaggagaa acacaggaaa     1380

tga                                                                   1383


<210>  5
<211>  2706
<212>  DNA
<213>  Homo sapiens

<400>  5
atgttgtgga aaataaccga taatgtcaag tacgaagagg actgcgagga tcgccacgac       60

gggagcagca atgggaatcc gcgggtcccc cacctctcct ccgccgggca gcacctctac      120

agccccgcgc cacccctctc ccacactgga gtcgccgaat atcagccgcc accctacttt      180

ccccctccct accagcagct ggcctactcc cagtcggccg acccctactc gcatctgggg      240

gaagcgtacg ccgccgccat caaccccctg caccagccgg cgcccacagg cagccagcag      300

caggcctggc ccggccgcca gagccaggag ggagcggggc tgccctcgca ccacgggcgc      360

ccggccggcc tactgcccca cctctccggg ctggaggcgg gcgcggtgag cgcccgcagg      420

gatgcctacc gccgctccga cctgctgctg ccccacgcac acgccctgga tgccgcgggc      480

ctggccgaga acctggggct ccacgacatg cctcaccaga tggacgaggt gcagaatgtc      540

gacgaccagc acctgttgct gcacgatcag acagtcattc gcaaaggtcc catttccatg      600

accaagaacc ctctgaacct cccctgtcag aaggagctgg tgggggccgt aatgaacccc      660

actgaggtct tctgctcagt ccctggaaga ttgtcgctcc tcagctctac gtctaaatac      720

aaagtgacag tggctgaagt acagaggcga ctgtccccac ctgaatgctt aaatgcctcg      780

ttactgggag gtgttctcag aagagccaaa tcgaaaaatg gaggccggtc cttgcgggag      840

aagttggaca agattgggtt gaatcttccg gccgggaggc ggaaagccgc tcatgtgact      900

ctcctgacat ccttagtaga aggtgaagct gttcatttgg ctagggactt tgcctatgtc      960

tgtgaagccg aatttcctag taaaccagtg gcagaatatt taaccagacc tcatcttgga     1020

ggacgaaatg agatggcagc taggaagaac atgctattgg cggcccagca actgtgtaaa     1080

gaattcacag aacttctcag ccaagaccgg acaccccatg ggaccagcag gctcgcccca     1140

gtcttggaga cgaacataca gaactgcttg tctcatttca gcctgattac ccacgggttt     1200

ggcagccagg ccatctgtgc cgcggtgtct gccctgcaga actacatcaa agaagccctg     1260

attgtcatag acaaatccta catgaaccct ggagaccaga gtccagctga ttctaacaaa     1320

accctggaga aaatggagaa acacaggaaa taaatgttgt ggaaaataac cgataatgtc     1380

aagtacgaag aggactgcga ggatcgccac gacgggagca gcaatgggaa tccgcgggtc     1440

ccccacctct cctccgccgg gcagcacctc tacagccccg cgccacccct ctcccacact     1500

ggagtcgccg aatatcagcc gccaccctac tttccccctc cctaccagca gctggcctac     1560

tcccagtcgg ccgaccccta ctcgcatctg ggggaagcgt acgccgccgc catcaacccc     1620

ctgcaccagc cggcgcccac aggcagccag cagcaggcct ggcccggccg ccagagccag     1680

gagggagcgg ggctgccctc gcaccacggg cgcccggccg gcctactgcc ccacctctcc     1740

gggctggagg cgggcgcggt gagcgcccgc agggatgcct accgccgctc cgacctgctg     1800

ctgccccacg cacacgccct ggatgccgcg ggcctggccg agaacctggg gctccacgac     1860

atgcctcacc agatggacga ggtgcagaat gtcgacgacc agcacctgtt gctgcacgat     1920

cagacagtca ttcgcaaagg tcccatttcc atgaccaaga accctctgaa cctcccctgt     1980

cagaaggagc tggtgggggc cgtaatgaac cccactgagg tcttctgctc agtccctgga     2040

agattgtcgc tcctcagctc tacgtctaaa tacaaagtga cagtggctga agtacagagg     2100

cgactgtccc cacctgaatg cttaaatgcc tcgttactgg gaggtgttct cagaagagcc     2160

aaatcgaaaa atggaggccg gtccttgcgg gagaagttgg acaagattgg gttgaatctt     2220

ccggccggga ggcggaaagc cgctcatgtg actctcctga catccttagt agaaggtgaa     2280

gctgttcatt tggctaggga ctttgcctat gtctgtgaag ccgaatttcc tagtaaacca     2340

gtggcagaat atttaaccag acctcatctt ggaggacgaa atgagatggc agctaggaag     2400

aacatgctat tggcggccca gcaactgtgt aaagaattca cagaacttct cagccaagac     2460

cggacacccc atgggaccag caggctcgcc ccagtcttgg agacgaacat acagaactgc     2520

ttgtctcatt tcagcctgat tacccacggg tttggcagcc aggccatctg tgccgcggtg     2580

tctgccctgc agaactacat caaagaagcc ctgattgtca tagacaaatc ctacatgaac     2640

cctggagacc agagtccagc tgattctaac aaaaccctgg agaaaatgga gaaacacagg     2700

aaataa                                                                2706


<210>  6
<211>  2040
<212>  DNA
<213>  Homo sapiens

<400>  6
acaataaaat gtgtgcaaat actctccaca gagataagtc cccacctcag tcggtataga       60

aaagcatgat aaaggttgga aaaaatggat aaaaatgttg aaagaacctc cagttcctta      120

ttaggcgaag atacaatatt tattccttgt ctcctgggat aaatctcttc tgcctattgt      180

cctcccagtt ctcagtgctg atgcttaatt ttcaaaactt ctatattacc aagggaccta      240

cgacatcagc caaagaaata ctcagcaagt acaaaatctg ttccagggag ctgcttttgt      300

gcagagggaa aattttgttc ctacaggttt ttaagtgggt acgaggcaag gagctatctg      360

atccgggcaa aaccattaca atttagatat ctacctatag aacatttttt ttttccttta      420

aaaattggaa aatacaagaa gtttggattt ttttttcccg attctttttt tggaggggga      480

aattgcatcg taagctttcg gagaaaccca acatgtcaac tacctttccg ggactagtcc      540

acgatgccga gatacgtcac gacggatcaa acagctaccg tttgatgcag cttggctgtc      600

tggagtcagt agccaattcc actgtcgcct attcctcctc ctctccttta acttactcca      660

ccaccggcac cgagtttgcg tccccctact tctccactaa ccaccagtac accccgctcc      720

accaccagtc cttccattac gagtttcagc acagccaccc ggccgtcacc cccgacgcct      780

actctctgaa ctctctccac cactcgcaac agtactacca gcagatccac cacggggagc      840

ccaccgactt tattaacctg cacaatgcgc gggcgctcaa gtcgtcctgc ctggacgagc      900

agaggcggga gctgggctgc ctcgatgcct accgccgcca tgacctgtcc ctcatgagcc      960

atggctctca gtatggaatg cacccagatc aaagactcct gccagggccc agcctggggc     1020

tggccgccgc gggagcagac gacttgcagg gctctgtgga ggcccagtgt gggcttgttc     1080

tcaatggcca aggtggagtg ataagaagag gtggcacctg tgtggtcaac cccacagact     1140

tattttgctc tgtccctggc cgtttgtccc ttcttagttc tacttccaaa tacaaggtga     1200

ccattgctga ggtaaagagg cgcctctccc cacctgagtg cctcaatgct tcactcttgg     1260

gaggcatttt gagaagagca aaatcaaaga atgggggccg ctgcctgaga gagaaattgg     1320

ataggcttgg cttaaactta ccagcaggaa gacggaaagc agctaatgtc accctcctta     1380

cttccttggt tgaaggggag gctttgcact tggctcggga ttttggctac acttgtgaaa     1440

cagagtttcc agccaaagca gtaggagaac atcttgccag acaacatatg gaacagaaag     1500

aacagacagc aagaaaaaag atgatcctgg cgaccaaaca aatctgtaaa gaattccaag     1560

acctcttgag ccaagataga tcaccactgg gatcctccag acccactcca attctagacc     1620

ttgacatcca gagacattta acacatttca gtttgatcac tcatggcttt gggactccgg     1680

caatatgtgc agctctaagc actttccaaa cagttctcag tgaaatgctg aactacttgg     1740

aaaaacacac tactcacaag aacggcggag cggcggattc tggccaagga catgccaact     1800

cggagaaagc tcccctgcgg aaaacttcag aggctgccgt gaaagagggc aaaacagaaa     1860

agacagacta gctacatcaa acagaatcta tttccagaga gtcttgctgc tgatattttt     1920

tctaatatat atatcattga gggtgactaa tcttcagtgg accaaatctc tacccttccc     1980

caaccctcca taaaaaaaca aaaatggaaa tgaaaaatga aacaaaaaag gacaaaacca     2040


<210>  7
<211>  2245
<212>  DNA
<213>  Homo sapiens

<400>  7
agaggaggaa gggcgggcgc tgggcacccg ttgaccgact tttccaagtg cgatcagtgc       60

ccgtccgtcc tgcctccatg gacccgcccg ggaacggcca ccgctgagga ccccacgccc      120

actaggatcc cggctgggtc gcacccagct accgcaccgt gacctccgcg ggctgtgccg      180

gctcccggcg cctctgcccg cagcgctcgc cgtcgggcta gggctccgcc gccgccacgc      240

ctcgcgcccg gcactcaccg ccccatgctg gtgcacacct actccgccat ggagcgcccc      300

gacgggctgg gagcagctgc cggcggggcc cgcctgtcgt ctctgcccca ggcggcctac      360

gggccggcgc ccccgctctg ccacacgccg gccgccacag ctgccgccga attccagccg      420

ccctacttcc cgccgcccta cccgcagcca ccgctgccct acggtcaggc gcccgacgcc      480

gccgcagcct ttccccacct ggcaggggac ccatatggcg gcctggcgcc cctggcgcag      540

ccgcagcctc ctcaggccgc ctgggccgcg ccccgcgcag ccgcccgcgc ccacgaggag      600

cctcccggcc tgctggcacc gcccgcccgc gccctgggcc ttgacccgcg ccgtgactat      660

gccactgccg tgccccggct cctgcacggc ctggccgacg gcgcgcacgg cctggcagac      720

gcacctctcg gccttccggg gctggcggcg gcccccggtc tggaggacct gcaggcaatg      780

gacgagccgg gaatgagcct cctagaccag tccgtgatca agaaagtgcc catcccctcc      840

aaagccagca gcctctcagc cctctccttg gccaaagaca gcctggtggg cggcatcaca      900

aatcctggtg aggtcttctg ctccgtgccc ggccggcttt cactgctcag ctcaacgtcc      960

aagtacaagg tgacggtggg ggaggtgcag cggcgactct cgcctcccga gtgcctcaac     1020

gcctccctcc tggggggtgt cctccgcagg gccaagtcca aaaatggggg ccggtgtttg     1080

cgggaacggt tagagaagat tgggctcaac ctgccagctg gccgtcgcaa ggccgccaat     1140

gtgacgctgc tgacttcgct agtggaagga gaggccgtgc acctggcccg agacttcggt     1200

tacgtctgtg agacggagtt cccagccaag gcagctgccg agtacctgtg ccgacagcac     1260

gctgacccgg gggagctgca cagccgcaag agcatgctgc tggctgccaa gcagatctgc     1320

aaggagtttg cagacttgat ggctcaggac cgctcaccgc tgggcaacag ccgcccagca     1380

ctcatcctgg agcccggagt acagagctgc ttgacacact ttagcctcat cacccatggc     1440

ttcggtgggc ctgccatctg tgctgccctc actgccttcc agaactattt gctggagtca     1500

ctcaaggggc tggacaagat gtttctaagc agtgtgggca gtgggcatgg tgaaaccaag     1560

gcttcggaga aggatgccaa gcatcggaaa taactgcttc tcccacccca tccctaaggg     1620

gctcccaggc cctgaaatag ggacttagct cttgggggtg ggcctggaag gactgaaagg     1680

tgggattaga gtcaggccag aaagagaaca ttcatccaga gatcccagag ttggggatct     1740

ggcttggagt aagggagggt ggcctctctg tggtggtgtg ttggtaagtt aagggcccag     1800

gtatttgtct catgtgtgca attttctgac ctttgatggt tgagaagggt ttggacagaa     1860

aattgacatg aaaagatctg gctcatgggg cagagccctt tccattagcg tggctgggtg     1920

gccgtgggtg cttctagagg ccaaagcctt tgtgtttttc actggtggca ggaggaaaat     1980

tgataaatca gaggtgctac tgaggagttg gtgcccctca ttccagaatc tcctaccccc     2040

agaaaagggg tgctggaagg aggccccagt ggactctttg tacccttcct actctcagag     2100

agaagtgggc aggaggggtc ctcaaggaac aaagaagata aagcacaaat cgcagaactt     2160

gaatccaggc tgctgctcat catagtcctg ttgctgtctg tcctatttat ttatgtatgt     2220

tgtaattaaa tttgaaattt taaaa                                           2245


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 1

<400>  8
ataccaggac gtgccgatgc                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide 2

<400>  9
cctccggcat cggcacgtcc                                                   20


<210>  10
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Repair template

<400>  10
acacttttgg cgatcaagga cagatacatc cttataacaa ttgaatgcca cagccactcc       60

acgcccttgg ggttgctctt ttcctcgggc atcggcacgt cctggtattg ctgaccacac      120

acaaaag                                                                127


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  11
ctcgatccac tccttacctc ac                                                22


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12
attgctgttg gacttggaca g                                                 21


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
taacagcggc atgaatctat tg                                                22


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
caggaagccg tctttattca tc                                                22


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
gatcagacag tcattcgcaa ag                                                22


<210>  16
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
gtagagctga ggagcgacaa tc                                                22


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
tgctaaaggc tggcacaa                                                     18


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
taatcgctgt gcgtgtagtg                                                   20


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
catgacctgg aatcagatga ac                                                22


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  20
cgtgcgtgtg tattctgtat tg                                                22


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21
agtacaaaag tgtgcccaac tg                                                22


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  22
tcgtttcagt tgttcaaagc ac                                                22


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
gtactgtcgg tttcagaaat gc                                                22


<210>  24
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  24
attcagctgg tcgatatcac tg                                                22


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  25
ggtgcagtga ccaatcagaa                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  26
aatccgtctt catccacagg                                                   20


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primers

<400>  27
cctggtgtca tgggtttcc                                                    19


<210>  28
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  28
gtcctgcagc acctgtctc                                                    19


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  29
tgcccttcaa cagattttgg                                                   20


<210>  30
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  30
gcagcctttc attccttcc                                                    19


<210>  31
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  31
tctcattcaa caagaaacca ctg                                               23


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  32
ttcacgtctg tcacttccac a                                                 21


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  33
acgatcagtc catcccagag                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  34
ttcacattgc acaaggcact                                                   20


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  35
aacagagcaa gatctgtatg ttcg                                              24


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  36
ccacaacttt tcttgtcaca gc                                                22


<210>  37
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  37
ctttccctac tgttcgttca cc                                                22


<210>  38
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  38
acgttatctg ctggagctct tc                                                22


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  39
ccagccatgt atgtggctat c                                                 21


<210>  40
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  40
cctcatagat ggggacattg tg                                                22


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  41
tgatggaaaa ggagttggac tt                                                22


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  42
caggtccttg gaaaccttga                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  43
cacggactct gtggagaacc                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  44
gcattcatag aggccatcgt                                                   20


<210>  45
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Leu Trp Lys Leu Thr Asp Asn Ile Lys Tyr Glu Asp Cys Glu Asp 
1               5                   10                  15      


Arg His Asp Gly Thr Ser Asn Gly Thr Ala Arg Leu Pro Gln Leu Gly 
            20                  25                  30          


Thr Val Gly Gln Ser Pro Tyr Thr Ser Ala Pro Pro Leu Ser His Thr 
        35                  40                  45              


Pro Asn Ala Asp Phe Gln Pro Pro Tyr Phe Pro Pro Pro Tyr Gln Pro 
    50                  55                  60                  


Ile Tyr Pro Gln Ser Gln Asp Pro Tyr Ser His Val Asn Asp Pro Tyr 
65                  70                  75                  80  


Ser Leu Asn Pro Leu His Ala Gln Pro Gln Pro Gln His Pro Gly Trp 
                85                  90                  95      


Pro Gly Gln Arg Gln Ser Gln Glu Ser Gly Leu Leu His Thr His Arg 
            100                 105                 110         


Gly Leu Pro His Gln Leu Ser Gly Leu Asp Pro Arg Arg Asp Tyr Arg 
        115                 120                 125             


Arg His Glu Asp Leu Leu His Gly Pro His Ala Leu Ser Ser Gly Leu 
    130                 135                 140                 


Gly Asp Leu Ser Ile His Ser Leu Pro His Ala Ile Glu Glu Val Pro 
145                 150                 155                 160 


His Val Glu Asp Pro Gly Ile Asn Ile Pro Asp Gln Thr Val Ile Lys 
                165                 170                 175     


Lys Gly Pro Val Ser Leu Ser Lys Ser Asn Ser Asn Ala Val Ser Ala 
            180                 185                 190         


Ile Pro Ile Asn Lys Asp Asn Leu Phe Gly Gly Val Val Asn Pro Asn 
        195                 200                 205             


Glu Val Phe Cys Ser Val Pro Gly Arg Leu Ser Leu Leu Ser Ser Thr 
    210                 215                 220                 


Ser Lys Tyr Lys Val Thr Val Ala Glu Val Gln Arg Arg Leu Ser Pro 
225                 230                 235                 240 


Pro Glu Cys Leu Asn Ala Ser Leu Leu Gly Gly Val Leu Arg Arg Ala 
                245                 250                 255     


Lys Ser Lys Asn Gly Gly Arg Ser Leu Arg Glu Lys Leu Asp Lys Ile 
            260                 265                 270         


Gly Leu Asn Leu Pro Ala Gly Arg Arg Lys Ala Ala Asn Val Thr Leu 
        275                 280                 285             


Leu Thr Ser Leu Val Glu Gly Glu Ala Val His Leu Ala Arg Asp Phe 
    290                 295                 300                 


Gly Tyr Val Cys Glu Thr Glu Phe Pro Ala Lys Ala Val Ala Glu Phe 
305                 310                 315                 320 


Leu Asn Arg Gln His Ser Asp Pro Asn Glu Gln Val Thr Arg Lys Asn 
                325                 330                 335     


Met Leu Leu Ala Thr Lys Gln Ile Cys Lys Glu Phe Thr Asp Leu Leu 
            340                 345                 350         


Ala Gln Asp Arg Ser Pro Leu Gly Asn Ser Arg Pro Asn Pro Ile Leu 
        355                 360                 365             


Glu Pro Gly Ile Gln Ser Cys Leu Thr His Phe Asn Leu Ile Ser His 
    370                 375                 380                 


Gly Phe Gly Ser Pro Ala Val Cys Ala Ala Val Thr Ala Leu Gln Asn 
385                 390                 395                 400 


Tyr Leu Thr Glu Ala Leu Lys Ala Met Asp Lys Met Tyr Leu Ser Asn 
                405                 410                 415     


Asn Pro Asn Ser His Thr Asp Asn Asn Ala Lys Ser Ser Asp Lys Glu 
            420                 425                 430         


Glu Lys His Arg Lys 
        435         


<210>  46
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Leu Val His Ser Phe Ser Ala Met Asp Arg His Asp Gly Thr Ser 
1               5                   10                  15      


Asn Gly Thr Ala Arg Leu Pro Gln Leu Gly Thr Val Gly Gln Ser Pro 
            20                  25                  30          


Tyr Thr Ser Ala Pro Pro Leu Ser His Thr Pro Asn Ala Asp Phe Gln 
        35                  40                  45              


Pro Pro Tyr Phe Pro Pro Pro Tyr Gln Pro Ile Tyr Pro Gln Ser Gln 
    50                  55                  60                  


Asp Pro Tyr Ser His Val Asn Asp Pro Tyr Ser Leu Asn Pro Leu His 
65                  70                  75                  80  


Ala Gln Pro Gln Pro Gln His Pro Gly Trp Pro Gly Gln Arg Gln Ser 
                85                  90                  95      


Gln Glu Ser Gly Leu Leu His Thr His Arg Gly Leu Pro His Gln Leu 
            100                 105                 110         


Ser Gly Leu Asp Pro Arg Arg Asp Tyr Arg Arg His Glu Asp Leu Leu 
        115                 120                 125             


His Gly Pro His Ala Leu Ser Ser Gly Leu Gly Asp Leu Ser Ile His 
    130                 135                 140                 


Ser Leu Pro His Ala Ile Glu Glu Val Pro His Val Glu Asp Pro Gly 
145                 150                 155                 160 


Ile Asn Ile Pro Asp Gln Thr Val Ile Lys Lys Gly Pro Val Ser Leu 
                165                 170                 175     


Ser Lys Ser Asn Ser Asn Ala Val Ser Ala Ile Pro Ile Asn Lys Asp 
            180                 185                 190         


Asn Leu Phe Gly Gly Val Val Asn Pro Asn Glu Val Phe Cys Ser Val 
        195                 200                 205             


Pro Gly Arg Leu Ser Leu Leu Ser Ser Thr Ser Lys Tyr Lys Val Thr 
    210                 215                 220                 


Val Ala Glu Val Gln Arg Arg Leu Ser Pro Pro Glu Cys Leu Asn Ala 
225                 230                 235                 240 


Ser Leu Leu Gly Gly Val Leu Arg Arg Ala Lys Ser Lys Asn Gly Gly 
                245                 250                 255     


Arg Ser Leu Arg Glu Lys Leu Asp Lys Ile Gly Leu Asn Leu Pro Ala 
            260                 265                 270         


Gly Arg Arg Lys Ala Ala Asn Val Thr Leu Leu Thr Ser Leu Val Glu 
        275                 280                 285             


Gly Glu Ala Val His Leu Ala Arg Asp Phe Gly Tyr Val Cys Glu Thr 
    290                 295                 300                 


Glu Phe Pro Ala Lys Ala Val Ala Glu Phe Leu Asn Arg Gln His Ser 
305                 310                 315                 320 


Asp Pro Asn Glu Gln Val Thr Arg Lys Asn Met Leu Leu Ala Thr Lys 
                325                 330                 335     


Gln Ile Cys Lys Glu Phe Thr Asp Leu Leu Ala Gln Asp Arg Ser Pro 
            340                 345                 350         


Leu Gly Asn Ser Arg Pro Asn Pro Ile Leu Glu Pro Gly Ile Gln Ser 
        355                 360                 365             


Cys Leu Thr His Phe Asn Leu Ile Ser His Gly Phe Gly Ser Pro Ala 
    370                 375                 380                 


Val Cys Ala Ala Val Thr Ala Leu Gln Asn Tyr Leu Thr Glu Ala Leu 
385                 390                 395                 400 


Lys Ala Met Asp Lys Met Tyr Leu Ser Asn Asn Pro Asn Ser His Thr 
                405                 410                 415     


Asp Asn Asn Ala Lys Ser Ser Asp Lys Glu Glu Lys His Arg Lys 
            420                 425                 430     


<210>  47
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ser Ile Leu Ala Lys Met Gly Asp Trp Gln Asp Arg His Asp Gly 
1               5                   10                  15      


Thr Ser Asn Gly Thr Ala Arg Leu Pro Gln Leu Gly Thr Val Gly Gln 
            20                  25                  30          


Ser Pro Tyr Thr Ser Ala Pro Pro Leu Ser His Thr Pro Asn Ala Asp 
        35                  40                  45              


Phe Gln Pro Pro Tyr Phe Pro Pro Pro Tyr Gln Pro Ile Tyr Pro Gln 
    50                  55                  60                  


Ser Gln Asp Pro Tyr Ser His Val Asn Asp Pro Tyr Ser Leu Asn Pro 
65                  70                  75                  80  


Leu His Ala Gln Pro Gln Pro Gln His Pro Gly Trp Pro Gly Gln Arg 
                85                  90                  95      


Gln Ser Gln Glu Ser Gly Leu Leu His Thr His Arg Gly Leu Pro His 
            100                 105                 110         


Gln Leu Ser Gly Leu Asp Pro Arg Arg Asp Tyr Arg Arg His Glu Asp 
        115                 120                 125             


Leu Leu His Gly Pro His Ala Leu Ser Ser Gly Leu Gly Asp Leu Ser 
    130                 135                 140                 


Ile His Ser Leu Pro His Ala Ile Glu Glu Val Pro His Val Glu Asp 
145                 150                 155                 160 


Pro Gly Ile Asn Ile Pro Asp Gln Thr Val Ile Lys Lys Gly Pro Val 
                165                 170                 175     


Ser Leu Ser Lys Ser Asn Ser Asn Ala Val Ser Ala Ile Pro Ile Asn 
            180                 185                 190         


Lys Asp Asn Leu Phe Gly Gly Val Val Asn Pro Asn Glu Val Phe Cys 
        195                 200                 205             


Ser Val Pro Gly Arg Leu Ser Leu Leu Ser Ser Thr Ser Lys Tyr Lys 
    210                 215                 220                 


Val Thr Val Ala Glu Val Gln Arg Arg Leu Ser Pro Pro Glu Cys Leu 
225                 230                 235                 240 


Asn Ala Ser Leu Leu Gly Gly Val Leu Arg Arg Ala Lys Ser Lys Asn 
                245                 250                 255     


Gly Gly Arg Ser Leu Arg Glu Lys Leu Asp Lys Ile Gly Leu Asn Leu 
            260                 265                 270         


Pro Ala Gly Arg Arg Lys Ala Ala Asn Val Thr Leu Leu Thr Ser Leu 
        275                 280                 285             


Val Glu Gly Glu Ala Val His Leu Ala Arg Asp Phe Gly Tyr Val Cys 
    290                 295                 300                 


Glu Thr Glu Phe Pro Ala Lys Ala Val Ala Glu Phe Leu Asn Arg Gln 
305                 310                 315                 320 


His Ser Asp Pro Asn Glu Gln Val Thr Arg Lys Asn Met Leu Leu Ala 
                325                 330                 335     


Thr Lys Gln Ile Cys Lys Glu Phe Thr Asp Leu Leu Ala Gln Asp Arg 
            340                 345                 350         


Ser Pro Leu Gly Asn Ser Arg Pro Asn Pro Ile Leu Glu Pro Gly Ile 
        355                 360                 365             


Gln Ser Cys Leu Thr His Phe Asn Leu Ile Ser His Gly Phe Gly Ser 
    370                 375                 380                 


Pro Ala Val Cys Ala Ala Val Thr Ala Leu Gln Asn Tyr Leu Thr Glu 
385                 390                 395                 400 


Ala Leu Lys Ala Met Asp Lys Met Tyr Leu Ser Asn Asn Pro Asn Ser 
                405                 410                 415     


His Thr Asp Asn Asn Ala Lys Ser Ser Asp Lys Glu Glu Lys His Arg 
            420                 425                 430         


Lys 
    


<210>  48
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  48

Met His Ser Pro Pro Arg Asp Gln Ala Ala Ile Met Leu Trp Lys Leu 
1               5                   10                  15      


Val Glu Asn Val Lys Tyr Glu Asp Ile Tyr Glu Asp Arg His Asp Gly 
            20                  25                  30          


Val Pro Ser His Ser Ser Arg Leu Ser Gln Leu Gly Ser Val Ser Gln 
        35                  40                  45              


Gly Pro Tyr Ser Ser Ala Pro Pro Leu Ser His Thr Pro Ser Ser Asp 
    50                  55                  60                  


Phe Gln Pro Pro Tyr Phe Pro Pro Pro Tyr Gln Pro Leu Pro Tyr His 
65                  70                  75                  80  


Gln Ser Gln Asp Pro Tyr Ser His Val Asn Asp Pro Tyr Ser Leu Asn 
                85                  90                  95      


Pro Leu His Gln Pro Gln Gln His Pro Trp Gly Gln Arg Gln Arg Gln 
            100                 105                 110         


Glu Val Gly Ser Glu Ala Gly Ser Leu Leu Pro Gln Pro Arg Ala Ala 
        115                 120                 125             


Leu Pro Gln Leu Ser Gly Leu Asp Pro Arg Arg Asp Tyr His Ser Val 
    130                 135                 140                 


Arg Arg Pro Asp Val Leu Leu His Ser Ala His His Gly Leu Asp Ala 
145                 150                 155                 160 


Gly Met Gly Asp Ser Leu Ser Leu His Gly Leu Gly His Pro Gly Met 
                165                 170                 175     


Glu Asp Val Gln Ser Val Glu Asp Ala Asn Asn Ser Gly Met Asn Leu 
            180                 185                 190         


Leu Asp Gln Ser Val Ile Lys Lys Val Pro Val Pro Pro Lys Ser Val 
        195                 200                 205             


Thr Ser Leu Met Met Asn Lys Asp Gly Phe Leu Gly Gly Met Ser Val 
    210                 215                 220                 


Asn Thr Gly Glu Val Phe Cys Ser Val Pro Gly Arg Leu Ser Leu Leu 
225                 230                 235                 240 


Ser Ser Thr Ser Lys Tyr Lys Val Thr Val Gly Glu Val Gln Arg Arg 
                245                 250                 255     


Leu Ser Pro Pro Glu Cys Leu Asn Ala Ser Leu Leu Gly Gly Val Leu 
            260                 265                 270         


Arg Arg Ala Lys Ser Lys Asn Gly Gly Arg Ser Leu Arg Glu Arg Leu 
        275                 280                 285             


Glu Lys Ile Gly Leu Asn Leu Pro Ala Gly Arg Arg Lys Ala Ala Asn 
    290                 295                 300                 


Val Thr Leu Leu Thr Ser Leu Val Glu Gly Glu Ala Val His Leu Ala 
305                 310                 315                 320 


Arg Asp Phe Gly Tyr Ile Cys Glu Thr Glu Phe Pro Ala Lys Ala Val 
                325                 330                 335     


Ser Glu Tyr Leu Asn Arg Gln His Thr Asp Pro Ser Asp Leu His Ser 
            340                 345                 350         


Arg Lys Asn Met Leu Leu Ala Thr Lys Gln Leu Cys Lys Glu Phe Thr 
        355                 360                 365             


Asp Leu Leu Ala Gln Asp Arg Thr Pro Ile Gly Asn Ser Arg Pro Ser 
    370                 375                 380                 


Pro Ile Leu Glu Pro Gly Ile Gln Ser Cys Leu Thr His Phe Ser Leu 
385                 390                 395                 400 


Ile Thr His Gly Phe Gly Ala Pro Ala Ile Cys Ala Ala Leu Thr Ala 
                405                 410                 415     


Leu Gln Asn Tyr Leu Thr Glu Ala Leu Lys Gly Met Asp Lys Met Phe 
            420                 425                 430         


Leu Asn Asn Thr Thr Thr Asn Arg His Thr Ser Gly Glu Gly Pro Gly 
        435                 440                 445             


Ser Lys Thr Gly Asp Lys Glu Glu Lys His Arg Lys 
    450                 455                 460 


<210>  49
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Leu Trp Lys Ile Thr Asp Asn Val Lys Tyr Glu Glu Asp Cys Glu 
1               5                   10                  15      


Asp Arg His Asp Gly Ser Ser Asn Gly Asn Pro Arg Val Pro His Leu 
            20                  25                  30          


Ser Ser Ala Gly Gln His Leu Tyr Ser Pro Ala Pro Pro Leu Ser His 
        35                  40                  45              


Thr Gly Val Ala Glu Tyr Gln Pro Pro Pro Tyr Phe Pro Pro Pro Tyr 
    50                  55                  60                  


Gln Gln Leu Ala Tyr Ser Gln Ser Ala Asp Pro Tyr Ser His Leu Gly 
65                  70                  75                  80  


Glu Ala Tyr Ala Ala Ala Ile Asn Pro Leu His Gln Pro Ala Pro Thr 
                85                  90                  95      


Gly Ser Gln Gln Gln Ala Trp Pro Gly Arg Gln Ser Gln Glu Gly Ala 
            100                 105                 110         


Gly Leu Pro Ser His His Gly Arg Pro Ala Gly Leu Leu Pro His Leu 
        115                 120                 125             


Ser Gly Leu Glu Ala Gly Ala Val Ser Ala Arg Arg Asp Ala Tyr Arg 
    130                 135                 140                 


Arg Ser Asp Leu Leu Leu Pro His Ala His Ala Leu Asp Ala Ala Gly 
145                 150                 155                 160 


Leu Ala Glu Asn Leu Gly Leu His Asp Met Pro His Gln Met Asp Glu 
                165                 170                 175     


Val Gln Asn Val Asp Asp Gln His Leu Leu Leu His Asp Gln Thr Val 
            180                 185                 190         


Ile Arg Lys Gly Pro Ile Ser Met Thr Lys Asn Pro Leu Asn Leu Pro 
        195                 200                 205             


Cys Gln Lys Glu Leu Val Gly Ala Val Met Asn Pro Thr Glu Val Phe 
    210                 215                 220                 


Cys Ser Val Pro Gly Arg Leu Ser Leu Leu Ser Ser Thr Ser Lys Tyr 
225                 230                 235                 240 


Lys Val Thr Val Ala Glu Val Gln Arg Arg Leu Ser Pro Pro Glu Cys 
                245                 250                 255     


Leu Asn Ala Ser Leu Leu Gly Gly Val Leu Arg Arg Ala Lys Ser Lys 
            260                 265                 270         


Asn Gly Gly Arg Ser Leu Arg Glu Lys Leu Asp Lys Ile Gly Leu Asn 
        275                 280                 285             


Leu Pro Ala Gly Arg Arg Lys Ala Ala His Val Thr Leu Leu Thr Ser 
    290                 295                 300                 


Leu Val Glu Gly Glu Ala Val His Leu Ala Arg Asp Phe Ala Tyr Val 
305                 310                 315                 320 


Cys Glu Ala Glu Phe Pro Ser Lys Pro Val Ala Glu Tyr Leu Thr Arg 
                325                 330                 335     


Pro His Leu Gly Gly Arg Asn Glu Met Ala Ala Arg Lys Asn Met Leu 
            340                 345                 350         


Leu Ala Ala Gln Gln Leu Cys Lys Glu Phe Thr Glu Leu Leu Ser Gln 
        355                 360                 365             


Asp Arg Thr Pro His Gly Thr Ser Arg Leu Ala Pro Val Leu Glu Thr 
    370                 375                 380                 


Asn Ile Gln Asn Cys Leu Ser His Phe Ser Leu Ile Thr His Gly Phe 
385                 390                 395                 400 


Gly Ser Gln Ala Ile Cys Ala Ala Val Ser Ala Leu Gln Asn Tyr Ile 
                405                 410                 415     


Lys Glu Ala Leu Ile Val Ile Asp Lys Ser Tyr Met Asn Pro Gly Asp 
            420                 425                 430         


Gln Ser Pro Ala Asp Ser Asn Lys Thr Leu Glu Lys Met Glu Lys His 
        435                 440                 445             


Arg Lys 
    450 


<210>  50
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ser Thr Thr Phe Pro Gly Leu Val His Asp Ala Glu Ile Arg His 
1               5                   10                  15      


Asp Gly Ser Asn Ser Tyr Arg Leu Met Gln Leu Gly Cys Leu Glu Ser 
            20                  25                  30          


Val Ala Asn Ser Thr Val Ala Tyr Ser Ser Ser Ser Pro Leu Thr Tyr 
        35                  40                  45              


Ser Thr Thr Gly Thr Glu Phe Ala Ser Pro Tyr Phe Ser Thr Asn His 
    50                  55                  60                  


Gln Tyr Thr Pro Leu His His Gln Ser Phe His Tyr Glu Phe Gln His 
65                  70                  75                  80  


Ser His Pro Ala Val Thr Pro Asp Ala Tyr Ser Leu Asn Ser Leu His 
                85                  90                  95      


His Ser Gln Gln Tyr Tyr Gln Gln Ile His His Gly Glu Pro Thr Asp 
            100                 105                 110         


Phe Ile Asn Leu His Asn Ala Arg Ala Leu Lys Ser Ser Cys Leu Asp 
        115                 120                 125             


Glu Gln Arg Arg Glu Leu Gly Cys Leu Asp Ala Tyr Arg Arg His Asp 
    130                 135                 140                 


Leu Ser Leu Met Ser His Gly Ser Gln Tyr Gly Met His Pro Asp Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Gly Pro Ser Leu Gly Leu Ala Ala Ala Gly Ala Asp 
                165                 170                 175     


Asp Leu Gln Gly Ser Val Glu Ala Gln Cys Gly Leu Val Leu Asn Gly 
            180                 185                 190         


Gln Gly Gly Val Ile Arg Arg Gly Gly Thr Cys Val Val Asn Pro Thr 
        195                 200                 205             


Asp Leu Phe Cys Ser Val Pro Gly Arg Leu Ser Leu Leu Ser Ser Thr 
    210                 215                 220                 


Ser Lys Tyr Lys Val Thr Ile Ala Glu Val Lys Arg Arg Leu Ser Pro 
225                 230                 235                 240 


Pro Glu Cys Leu Asn Ala Ser Leu Leu Gly Gly Ile Leu Arg Arg Ala 
                245                 250                 255     


Lys Ser Lys Asn Gly Gly Arg Cys Leu Arg Glu Lys Leu Asp Arg Leu 
            260                 265                 270         


Gly Leu Asn Leu Pro Ala Gly Arg Arg Lys Ala Ala Asn Val Thr Leu 
        275                 280                 285             


Leu Thr Ser Leu Val Glu Gly Glu Ala Leu His Leu Ala Arg Asp Phe 
    290                 295                 300                 


Gly Tyr Thr Cys Glu Thr Glu Phe Pro Ala Lys Ala Val Gly Glu His 
305                 310                 315                 320 


Leu Ala Arg Gln His Met Glu Gln Lys Glu Gln Thr Ala Arg Lys Lys 
                325                 330                 335     


Met Ile Leu Ala Thr Lys Gln Ile Cys Lys Glu Phe Gln Asp Leu Leu 
            340                 345                 350         


Ser Gln Asp Arg Ser Pro Leu Gly Ser Ser Arg Pro Thr Pro Ile Leu 
        355                 360                 365             


Asp Leu Asp Ile Gln Arg His Leu Thr His Phe Ser Leu Ile Thr His 
    370                 375                 380                 


Gly Phe Gly Thr Pro Ala Ile Cys Ala Ala Leu Ser Thr Phe Gln Thr 
385                 390                 395                 400 


Val Leu Ser Glu Met Leu Asn Tyr Leu Glu Lys His Thr Thr His Lys 
                405                 410                 415     


Asn Gly Gly Ala Ala Asp Ser Gly Gln Gly His Ala Asn Ser Glu Lys 
            420                 425                 430         


Ala Pro Leu Arg Lys Thr Ser Glu Ala Ala Val Lys Glu Gly Lys Thr 
        435                 440                 445             


Glu Lys Thr Asp 
    450         


<210>  51
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Leu Val His Thr Tyr Ser Ala Met Glu Arg Pro Asp Gly Leu Gly 
1               5                   10                  15      


Ala Ala Ala Gly Gly Ala Arg Leu Ser Ser Leu Pro Gln Ala Ala Tyr 
            20                  25                  30          


Gly Pro Ala Pro Pro Leu Cys His Thr Pro Ala Ala Thr Ala Ala Ala 
        35                  40                  45              


Glu Phe Gln Pro Pro Tyr Phe Pro Pro Pro Tyr Pro Gln Pro Pro Leu 
    50                  55                  60                  


Pro Tyr Gly Gln Ala Pro Asp Ala Ala Ala Ala Phe Pro His Leu Ala 
65                  70                  75                  80  


Gly Asp Pro Tyr Gly Gly Leu Ala Pro Leu Ala Gln Pro Gln Pro Pro 
                85                  90                  95      


Gln Ala Ala Trp Ala Ala Pro Arg Ala Ala Ala Arg Ala His Glu Glu 
            100                 105                 110         


Pro Pro Gly Leu Leu Ala Pro Pro Ala Arg Ala Leu Gly Leu Asp Pro 
        115                 120                 125             


Arg Arg Asp Tyr Ala Thr Ala Val Pro Arg Leu Leu His Gly Leu Ala 
    130                 135                 140                 


Asp Gly Ala His Gly Leu Ala Asp Ala Pro Leu Gly Leu Pro Gly Leu 
145                 150                 155                 160 


Ala Ala Ala Pro Gly Leu Glu Asp Leu Gln Ala Met Asp Glu Pro Gly 
                165                 170                 175     


Met Ser Leu Leu Asp Gln Ser Val Ile Lys Lys Val Pro Ile Pro Ser 
            180                 185                 190         


Lys Ala Ser Ser Leu Ser Ala Leu Ser Leu Ala Lys Asp Ser Leu Val 
        195                 200                 205             


Gly Gly Ile Thr Asn Pro Gly Glu Val Phe Cys Ser Val Pro Gly Arg 
    210                 215                 220                 


Leu Ser Leu Leu Ser Ser Thr Ser Lys Tyr Lys Val Thr Val Gly Glu 
225                 230                 235                 240 


Val Gln Arg Arg Leu Ser Pro Pro Glu Cys Leu Asn Ala Ser Leu Leu 
                245                 250                 255     


Gly Gly Val Leu Arg Arg Ala Lys Ser Lys Asn Gly Gly Arg Cys Leu 
            260                 265                 270         


Arg Glu Arg Leu Glu Lys Ile Gly Leu Asn Leu Pro Ala Gly Arg Arg 
        275                 280                 285             


Lys Ala Ala Asn Val Thr Leu Leu Thr Ser Leu Val Glu Gly Glu Ala 
    290                 295                 300                 


Val His Leu Ala Arg Asp Phe Gly Tyr Val Cys Glu Thr Glu Phe Pro 
305                 310                 315                 320 


Ala Lys Ala Ala Ala Glu Tyr Leu Cys Arg Gln His Ala Asp Pro Gly 
                325                 330                 335     


Glu Leu His Ser Arg Lys Ser Met Leu Leu Ala Ala Lys Gln Ile Cys 
            340                 345                 350         


Lys Glu Phe Ala Asp Leu Met Ala Gln Asp Arg Ser Pro Leu Gly Asn 
        355                 360                 365             


Ser Arg Pro Ala Leu Ile Leu Glu Pro Gly Val Gln Ser Cys Leu Thr 
    370                 375                 380                 


His Phe Ser Leu Ile Thr His Gly Phe Gly Gly Pro Ala Ile Cys Ala 
385                 390                 395                 400 


Ala Leu Thr Ala Phe Gln Asn Tyr Leu Leu Glu Ser Leu Lys Gly Leu 
                405                 410                 415     


Asp Lys Met Phe Leu Ser Ser Val Gly Ser Gly His Gly Glu Thr Lys 
            420                 425                 430         


Ala Ser Glu Lys Asp Ala Lys His Arg Lys 
        435                 440         


