﻿                         序列表

<110>  首都师范大学

<120>  人REV3L蛋白翻译后切割所依赖的序列元件及其应用

<160>  5

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Gln Leu Asp Gly Thr Ala Asp 
1               5           

<210>  2
<211>  3130
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Met Phe Ser Val Arg Ile Val Thr Ala Asp Tyr Tyr Met Ala Ser Pro 
1               5                   10                  15      
Leu Gln Gly Leu Asp Thr Cys Gln Ser Pro Leu Thr Gln Ala Pro Val 
            20                  25                  30          
Lys Lys Val Pro Val Val Arg Val Phe Gly Ala Thr Pro Ala Gly Gln 
        35                  40                  45              
Lys Thr Cys Leu His Leu His Gly Ile Phe Pro Tyr Leu Tyr Val Pro 
    50                  55                  60                  
Tyr Asp Gly Tyr Gly Gln Gln Pro Glu Ser Tyr Leu Ser Gln Met Ala 
65                  70                  75                  80  
Phe Ser Ile Asp Arg Ala Leu Asn Val Ala Leu Gly Asn Pro Ser Ser 
                85                  90                  95      
Thr Ala Gln His Val Phe Lys Val Ser Leu Val Ser Gly Met Pro Phe 
            100                 105                 110         
Tyr Gly Tyr His Glu Lys Glu Arg His Phe Met Lys Ile Tyr Leu Tyr 
        115                 120                 125             
Asn Pro Thr Met Val Lys Arg Ile Cys Glu Leu Leu Gln Ser Gly Ala 
    130                 135                 140                 
Ile Met Asn Lys Phe Tyr Gln Pro His Glu Ala His Ile Pro Tyr Leu 
145                 150                 155                 160 
Leu Gln Leu Phe Ile Asp Tyr Asn Leu Tyr Gly Met Asn Leu Ile Asn 
                165                 170                 175     
Leu Ala Ala Val Lys Phe Arg Lys Ala Arg Arg Lys Ser Asn Thr Leu 
            180                 185                 190         
His Ala Thr Gly Ser Cys Lys Asn His Leu Ser Gly Asn Ser Leu Ala 
        195                 200                 205             
Asp Thr Leu Phe Arg Trp Glu Gln Asp Glu Ile Pro Ser Ser Leu Ile 
    210                 215                 220                 
Leu Glu Gly Val Glu Pro Gln Ser Thr Cys Glu Leu Glu Val Asp Ala 
225                 230                 235                 240 
Val Ala Ala Asp Ile Leu Asn Arg Leu Asp Ile Glu Ala Gln Ile Gly 
                245                 250                 255     
Gly Asn Pro Gly Leu Gln Ala Ile Trp Glu Asp Glu Lys Gln Arg Arg 
            260                 265                 270         
Arg Asn Arg Asn Glu Thr Ser Gln Met Ser Gln Pro Glu Ser Gln Asp 
        275                 280                 285             
His Arg Phe Val Pro Ala Thr Glu Ser Glu Lys Lys Phe Gln Lys Arg 
    290                 295                 300                 
Leu Gln Glu Ile Leu Lys Gln Asn Asp Phe Ser Val Thr Leu Ser Gly 
305                 310                 315                 320 
Ser Val Asp Tyr Ser Asp Gly Ser Gln Glu Phe Ser Ala Glu Leu Thr 
                325                 330                 335     
Leu His Ser Glu Val Leu Ser Pro Glu Met Leu Gln Cys Thr Pro Ala 
            340                 345                 350         
Asn Met Val Glu Val His Lys Asp Lys Glu Ser Ser Lys Gly His Thr 
        355                 360                 365             
Arg His Lys Val Glu Glu Ala Leu Ile Asn Glu Glu Ala Ile Leu Asn 
    370                 375                 380                 
Leu Met Glu Asn Ser Gln Thr Phe Gln Pro Leu Thr Gln Arg Leu Ser 
385                 390                 395                 400 
Glu Ser Pro Val Phe Met Asp Ser Ser Pro Asp Glu Ala Leu Val His 
                405                 410                 415     
Leu Leu Ala Gly Leu Glu Ser Asp Gly Tyr Arg Gly Glu Arg Asn Arg 
            420                 425                 430         
Met Pro Ser Pro Cys Arg Ser Phe Gly Asn Asn Lys Tyr Pro Gln Asn 
        435                 440                 445             
Ser Asp Asp Glu Glu Asn Glu Pro Gln Ile Glu Lys Glu Glu Met Glu 
    450                 455                 460                 
Leu Ser Leu Val Met Ser Gln Arg Trp Asp Ser Asn Ile Glu Glu His 
465                 470                 475                 480 
Cys Ala Lys Lys Arg Ser Leu Cys Arg Asn Thr His Arg Ser Ser Thr 
                485                 490                 495     
Glu Asp Asp Asp Ser Ser Ser Gly Glu Glu Met Glu Trp Ser Asp Asn 
            500                 505                 510         
Ser Leu Leu Leu Ala Ser Leu Ser Ile Pro Gln Leu Asp Gly Thr Ala 
        515                 520                 525             
Asp Glu Asn Ser Asp Asn Pro Leu Asn Asn Glu Asn Ser Arg Thr His 
    530                 535                 540                 
Ser Ser Val Ile Ala Thr Ser Lys Leu Ser Val Lys Pro Ser Ile Phe 
545                 550                 555                 560 
His Lys Asp Ala Ala Thr Leu Glu Pro Ser Ser Ser Ala Lys Ile Thr 
                565                 570                 575     
Phe Gln Cys Lys His Thr Ser Ala Leu Ser Ser His Val Leu Asn Lys 
            580                 585                 590         
Glu Asp Leu Ile Glu Asp Leu Ser Gln Thr Asn Lys Asn Thr Glu Lys 
        595                 600                 605             
Gly Leu Asp Asn Ser Val Thr Ser Phe Thr Asn Glu Ser Thr Tyr Ser 
    610                 615                 620                 
Met Lys Tyr Pro Gly Ser Leu Ser Ser Thr Val His Ser Glu Asn Ser 
625                 630                 635                 640 
His Lys Glu Asn Ser Lys Lys Glu Ile Leu Pro Val Ser Ser Cys Glu 
                645                 650                 655     
Ser Ser Ile Phe Asp Tyr Glu Glu Asp Ile Pro Ser Val Thr Arg Gln 
            660                 665                 670         
Val Pro Ser Arg Lys Tyr Thr Asn Ile Arg Lys Ile Glu Lys Asp Ser 
        675                 680                 685             
Pro Phe Ile His Met His Arg His Pro Asn Glu Asn Thr Leu Gly Lys 
    690                 695                 700                 
Asn Ser Phe Asn Phe Ser Asp Leu Asn His Ser Lys Asn Lys Val Ser 
705                 710                 715                 720 
Ser Glu Gly Asn Glu Lys Gly Asn Ser Thr Ala Leu Ser Ser Leu Phe 
                725                 730                 735     
Pro Ser Ser Phe Thr Glu Asn Cys Glu Leu Leu Ser Cys Ser Gly Glu 
            740                 745                 750         
Asn Arg Thr Met Val His Ser Leu Asn Ser Thr Ala Asp Glu Ser Gly 
        755                 760                 765             
Leu Asn Lys Leu Lys Ile Arg Tyr Glu Glu Phe Gln Glu His Lys Thr 
    770                 775                 780                 
Glu Lys Pro Ser Leu Ser Gln Gln Ala Ala His Tyr Met Phe Phe Pro 
785                 790                 795                 800 
Ser Val Val Leu Ser Asn Cys Leu Thr Arg Pro Gln Lys Leu Ser Pro 
                805                 810                 815     
Val Thr Tyr Lys Leu Gln Pro Gly Asn Lys Pro Ser Arg Leu Lys Leu 
            820                 825                 830         
Asn Lys Arg Lys Leu Ala Gly His Gln Glu Thr Ser Thr Lys Ser Ser 
        835                 840                 845             
Glu Thr Gly Ser Thr Lys Asp Asn Phe Ile Gln Asn Asn Pro Cys Asn 
    850                 855                 860                 
Ser Asn Pro Glu Lys Asp Asn Ala Leu Ala Ser Asp Leu Thr Lys Thr 
865                 870                 875                 880 
Thr Arg Gly Ala Phe Glu Asn Lys Thr Pro Thr Asp Gly Phe Ile Asp 
                885                 890                 895     
Cys His Phe Gly Asp Gly Thr Leu Glu Thr Glu Gln Ser Phe Gly Leu 
            900                 905                 910         
Tyr Gly Asn Lys Tyr Thr Leu Arg Ala Lys Arg Lys Val Asn Tyr Glu 
        915                 920                 925             
Thr Glu Asp Ser Glu Ser Ser Phe Val Thr His Asn Ser Lys Ile Ser 
    930                 935                 940                 
Leu Pro His Pro Met Glu Ile Gly Glu Ser Leu Asp Gly Thr Leu Lys 
945                 950                 955                 960 
Ser Arg Lys Arg Arg Lys Met Ser Lys Lys Leu Pro Pro Val Ile Ile 
                965                 970                 975     
Lys Tyr Ile Ile Ile Asn Arg Phe Arg Gly Arg Lys Asn Met Leu Val 
            980                 985                 990         
Lys Leu Gly Lys Ile Asp Ser Lys  Glu Lys Gln Val Ile  Leu Thr Glu 
        995                 1000                 1005             
Glu Lys  Met Glu Leu Tyr Lys  Lys Leu Ala Pro Leu  Lys Asp Phe Trp 
    1010                 1015                 1020                 
Pro  Lys Val Pro Asp Ser  Pro Ala Thr Lys Tyr  Pro Ile Tyr Pro Leu  
1025                 1030                 1035                 1040 
Thr Pro Lys Lys Ser  His Arg Arg Lys Ser  Lys His Lys Ser Ala  Lys 
                1045                 1050                 1055     
Lys Lys Thr Gly  Lys Gln Gln Arg Thr  Asn Asn Glu Asn Ile  Lys Arg 
            1060                 1065                 1070         
Thr Leu Ser  Phe Arg Lys Lys Arg  Ser His Ala Ile Leu  Ser Pro Pro 
        1075                 1080                 1085             
Ser Pro  Ser Tyr Asn Ala Glu  Thr Glu Asp Cys Asp  Leu Asn Tyr Ser 
    1090                 1095                 1100                 
Asp  Val Met Ser Lys Leu  Gly Phe Leu Ser Glu  Arg Ser Thr Ser Pro  
1105                 1110                 1115                 1120 
Ile Asn Ser Ser Pro  Pro Arg Cys Trp Ser  Pro Thr Asp Pro Arg  Ala 
                1125                 1130                 1135     
Glu Glu Ile Met  Ala Ala Ala Glu Lys  Glu Ala Met Leu Phe  Lys Gly 
            1140                 1145                 1150         
Pro Asn Val  Tyr Lys Lys Thr Val  Asn Ser Arg Ile Gly  Lys Thr Ser 
        1155                 1160                 1165             
Arg Ala  Arg Ala Gln Ile Lys  Lys Ser Lys Ala Lys  Leu Ala Asn Pro 
    1170                 1175                 1180                 
Ser  Ile Val Thr Lys Lys  Arg Asn Lys Arg Asn  Gln Thr Asn Lys Leu  
1185                 1190                 1195                 1200 
Val Asp Asp Gly Lys  Lys Lys Pro Arg Ala  Lys Gln Lys Thr Asn  Glu 
                1205                 1210                 1215     
Lys Gly Thr Ser  Arg Lys His Thr Thr  Leu Lys Asp Glu Lys  Ile Lys 
            1220                 1225                 1230         
Ser Gln Ser  Gly Ala Glu Val Lys  Phe Val Leu Lys His  Gln Asn Val 
        1235                 1240                 1245             
Ser Glu  Phe Ala Ser Ser Ser  Gly Gly Ser Gln Leu  Leu Phe Lys Gln 
    1250                 1255                 1260                 
Lys  Asp Met Pro Leu Met  Gly Ser Ala Val Asp  His Pro Leu Ser Ala  
1265                 1270                 1275                 1280 
Ser Leu Pro Thr Gly  Ile Asn Ala Gln Gln  Lys Leu Ser Gly Cys  Phe 
                1285                 1290                 1295     
Ser Ser Phe Leu  Glu Ser Lys Lys Ser  Val Asp Leu Gln Thr  Phe Pro 
            1300                 1305                 1310         
Ser Ser Arg  Asp Asp Leu His Pro  Ser Val Val Cys Asn  Ser Ile Gly 
        1315                 1320                 1325             
Pro Gly  Val Ser Lys Ile Asn  Val Gln Arg Pro His  Asn Gln Ser Ala 
    1330                 1335                 1340                 
Met  Phe Thr Leu Lys Glu  Ser Thr Leu Ile Gln  Lys Asn Ile Phe Asp  
1345                 1350                 1355                 1360 
Leu Ser Asn His Leu  Ser Gln Val Ala Gln  Asn Thr Gln Ile Ser  Ser 
                1365                 1370                 1375     
Gly Met Ser Ser  Lys Ile Glu Asp Asn  Ala Asn Asn Ile Gln  Arg Asn 
            1380                 1385                 1390         
Tyr Leu Ser  Ser Ile Gly Lys Leu  Ser Glu Tyr Arg Asn  Ser Leu Glu 
        1395                 1400                 1405             
Ser Lys  Leu Asp Gln Ala Tyr  Thr Pro Asn Phe Leu  His Cys Lys Asp 
    1410                 1415                 1420                 
Ser  Gln Gln Gln Ile Val  Cys Ile Ala Glu Gln  Ser Lys His Ser Glu  
1425                 1430                 1435                 1440 
Thr Cys Ser Pro Gly  Asn Thr Ala Ser Glu  Glu Ser Gln Met Pro  Asn 
                1445                 1450                 1455     
Asn Cys Phe Val  Thr Ser Leu Arg Ser  Pro Ile Lys Gln Ile  Ala Trp 
            1460                 1465                 1470         
Glu Gln Lys  Gln Arg Gly Phe Ile  Leu Asp Met Ser Asn  Phe Lys Pro 
        1475                 1480                 1485             
Glu Arg  Val Lys Pro Arg Ser  Leu Ser Glu Ala Ile  Ser Gln Thr Lys 
    1490                 1495                 1500                 
Ala  Leu Ser Gln Cys Lys  Asn Arg Asn Val Ser  Thr Pro Ser Ala Phe  
1505                 1510                 1515                 1520 
Gly Glu Gly Gln Ser  Gly Leu Ala Val Leu  Lys Glu Leu Leu Gln  Lys 
                1525                 1530                 1535     
Arg Gln Gln Lys  Ala Gln Asn Ala Asn  Thr Thr Gln Asp Pro  Leu Ser 
            1540                 1545                 1550         
Asn Lys His  Gln Pro Asn Lys Asn  Ile Ser Gly Ser Leu  Glu His Asn 
        1555                 1560                 1565             
Lys Ala  Asn Lys Arg Thr Arg  Ser Val Thr Ser Pro  Arg Lys Pro Arg 
    1570                 1575                 1580                 
Thr  Pro Arg Ser Thr Lys  Gln Lys Glu Lys Ile  Pro Lys Leu Leu Lys  
1585                 1590                 1595                 1600 
Val Asp Ser Leu Asn  Leu Gln Asn Ser Ser  Gln Leu Asp Asn Ser  Val 
                1605                 1610                 1615     
Ser Asp Asp Ser  Pro Ile Phe Phe Ser  Asp Pro Gly Phe Glu  Ser Cys 
            1620                 1625                 1630         
Tyr Ser Leu  Glu Asp Ser Leu Ser  Pro Glu His Asn Tyr  Asn Phe Asp 
        1635                 1640                 1645             
Ile Asn  Thr Ile Gly Gln Thr  Gly Phe Cys Ser Phe  Tyr Ser Gly Ser 
    1650                 1655                 1660                 
Gln  Phe Val Pro Ala Asp  Gln Asn Leu Pro Gln  Lys Phe Leu Ser Asp  
1665                 1670                 1675                 1680 
Ala Val Gln Asp Leu  Phe Pro Gly Gln Ala  Ile Glu Lys Asn Glu  Phe 
                1685                 1690                 1695     
Leu Ser His Asp  Asn Gln Lys Cys Asp  Glu Asp Lys His His  Thr Thr 
            1700                 1705                 1710         
Asp Ser Ala  Ser Trp Ile Arg Ser  Gly Thr Leu Ser Pro  Glu Ile Phe 
        1715                 1720                 1725             
Glu Lys  Ser Thr Ile Asp Ser  Asn Glu Asn Arg Arg  His Asn Gln Trp 
    1730                 1735                 1740                 
Lys  Asn Ser Phe His Pro  Leu Thr Thr Arg Ser  Asn Ser Ile Met Asp  
1745                 1750                 1755                 1760 
Ser Phe Cys Val Gln  Gln Ala Glu Asp Cys  Leu Ser Glu Lys Ser  Arg 
                1765                 1770                 1775     
Leu Asn Arg Ser  Ser Val Ser Lys Glu  Val Phe Leu Ser Leu  Pro Gln 
            1780                 1785                 1790         
Pro Asn Asn  Ser Asp Trp Ile Gln  Gly His Thr Arg Lys  Glu Met Gly 
        1795                 1800                 1805             
Gln Ser  Leu Asp Ser Ala Asn  Thr Ser Phe Thr Ala  Ile Leu Ser Ser 
    1810                 1815                 1820                 
Pro  Asp Gly Glu Leu Val  Asp Val Ala Cys Glu  Asp Leu Glu Leu Tyr  
1825                 1830                 1835                 1840 
Val Ser Arg Asn Asn  Asp Met Leu Thr Pro  Thr Pro Asp Ser Ser  Pro 
                1845                 1850                 1855     
Arg Ser Thr Ser  Ser Pro Ser Gln Ser  Lys Asn Gly Ser Phe  Thr Pro 
            1860                 1865                 1870         
Arg Thr Ala  Asn Ile Leu Lys Pro  Leu Met Ser Pro Pro  Ser Arg Glu 
        1875                 1880                 1885             
Glu Ile  Met Ala Thr Leu Leu  Asp His Asp Leu Ser  Glu Thr Ile Tyr 
    1890                 1895                 1900                 
Gln  Glu Pro Phe Cys Ser  Asn Pro Ser Asp Val  Pro Glu Lys Pro Arg  
1905                 1910                 1915                 1920 
Glu Ile Gly Gly Arg  Leu Leu Met Val Glu  Thr Arg Leu Ala Asn  Asp 
                1925                 1930                 1935     
Leu Ala Glu Phe  Glu Gly Asp Phe Ser  Leu Glu Gly Leu Arg  Leu Trp 
            1940                 1945                 1950         
Lys Thr Ala  Phe Ser Ala Met Thr  Gln Asn Pro Arg Pro  Gly Ser Pro 
        1955                 1960                 1965             
Leu Arg  Ser Gly Gln Gly Val  Val Asn Lys Gly Ser  Ser Asn Ser Pro 
    1970                 1975                 1980                 
Lys  Met Val Glu Asp Lys  Lys Ile Val Ile Met  Pro Cys Lys Cys Ala  
1985                 1990                 1995                 2000 
Pro Ser Arg Gln Leu  Val Gln Val Trp Leu  Gln Ala Lys Glu Glu  Tyr 
                2005                 2010                 2015     
Glu Arg Ser Lys  Lys Leu Pro Lys Thr  Lys Pro Thr Gly Val  Val Lys 
            2020                 2025                 2030         
Ser Ala Glu  Asn Phe Ser Ser Ser  Val Asn Pro Asp Asp  Lys Pro Val 
        2035                 2040                 2045             
Val Pro  Pro Lys Met Asp Val  Ser Pro Cys Ile Leu  Pro Thr Thr Ala 
    2050                 2055                 2060                 
His  Thr Lys Glu Asp Val  Asp Asn Ser Gln Ile  Ala Leu Gln Ala Pro  
2065                 2070                 2075                 2080 
Thr Thr Gly Cys Ser  Gln Thr Ala Ser Glu  Ser Gln Met Leu Pro  Pro 
                2085                 2090                 2095     
Val Ala Ser Ala  Ser Asp Pro Glu Lys  Asp Glu Asp Asp Asp  Asp Asn 
            2100                 2105                 2110         
Tyr Tyr Ile  Ser Tyr Ser Ser Pro  Asp Ser Pro Val Ile  Pro Pro Trp 
        2115                 2120                 2125             
Gln Gln  Pro Ile Ser Pro Asp  Ser Lys Ala Leu Asn  Gly Asp Asp Arg 
    2130                 2135                 2140                 
Pro  Ser Ser Pro Val Glu  Glu Leu Pro Ser Leu  Ala Phe Glu Asn Phe  
2145                 2150                 2155                 2160 
Leu Lys Pro Ile Lys  Asp Gly Ile Gln Lys  Ser Pro Cys Ser Glu  Pro 
                2165                 2170                 2175     
Gln Glu Pro Leu  Val Ile Ser Pro Ile  Asn Thr Arg Ala Arg  Thr Gly 
            2180                 2185                 2190         
Lys Cys Glu  Ser Leu Cys Phe His  Ser Thr Pro Ile Ile  Gln Arg Lys 
        2195                 2200                 2205             
Leu Leu  Glu Arg Leu Pro Glu  Ala Pro Gly Leu Ser  Pro Leu Ser Thr 
    2210                 2215                 2220                 
Glu  Pro Lys Thr Gln Lys  Leu Ser Asn Lys Lys  Gly Ser Asn Thr Asp  
2225                 2230                 2235                 2240 
Thr Leu Arg Arg Val  Leu Leu Thr Gln Ala  Lys Asn Gln Phe Ala  Ala 
                2245                 2250                 2255     
Val Asn Thr Pro  Gln Lys Glu Thr Ser  Gln Ile Asp Gly Pro  Ser Leu 
            2260                 2265                 2270         
Asn Asn Thr  Tyr Gly Phe Lys Val  Ser Ile Gln Asn Leu  Gln Glu Ala 
        2275                 2280                 2285             
Lys Ala  Leu His Glu Ile Gln  Asn Leu Thr Leu Ile  Ser Val Glu Leu 
    2290                 2295                 2300                 
His  Ala Arg Thr Arg Arg  Asp Leu Glu Pro Asp  Pro Glu Phe Asp Pro  
2305                 2310                 2315                 2320 
Ile Cys Ala Leu Phe  Tyr Cys Ile Ser Ser  Asp Thr Pro Leu Pro  Asp 
                2325                 2330                 2335     
Thr Glu Lys Thr  Glu Leu Thr Gly Val  Ile Val Ile Asp Lys  Asp Lys 
            2340                 2345                 2350         
Thr Val Phe  Ser Gln Asp Ile Arg  Tyr Gln Thr Pro Leu  Leu Ile Arg 
        2355                 2360                 2365             
Ser Gly  Ile Thr Gly Leu Glu  Val Thr Tyr Ala Ala  Asp Glu Lys Ala 
    2370                 2375                 2380                 
Leu  Phe His Glu Ile Ala  Asn Ile Ile Lys Arg  Tyr Asp Pro Asp Ile  
2385                 2390                 2395                 2400 
Leu Leu Gly Tyr Glu  Ile Gln Met His Ser  Trp Gly Tyr Leu Leu  Gln 
                2405                 2410                 2415     
Arg Ala Ala Ala  Leu Ser Ile Asp Leu  Cys Arg Met Ile Ser  Arg Val 
            2420                 2425                 2430         
Pro Asp Asp  Lys Ile Glu Asn Arg  Phe Ala Ala Glu Arg  Asp Glu Tyr 
        2435                 2440                 2445             
Gly Ser  Tyr Thr Met Ser Glu  Ile Asn Ile Val Gly  Arg Ile Thr Leu 
    2450                 2455                 2460                 
Asn  Leu Trp Arg Ile Met  Arg Asn Glu Val Ala  Leu Thr Asn Tyr Thr  
2465                 2470                 2475                 2480 
Phe Glu Asn Val Ser  Phe His Val Leu His  Gln Arg Phe Pro Leu  Phe 
                2485                 2490                 2495     
Thr Phe Arg Val  Leu Ser Asp Trp Phe  Asp Asn Lys Thr Asp  Leu Tyr 
            2500                 2505                 2510         
Arg Trp Lys  Met Val Asp His Tyr  Val Ser Arg Val Arg  Gly Asn Leu 
        2515                 2520                 2525             
Gln Met  Leu Glu Gln Leu Asp  Leu Ile Gly Lys Thr  Ser Glu Met Ala 
    2530                 2535                 2540                 
Arg  Leu Phe Gly Ile Gln  Phe Leu His Val Leu  Thr Arg Gly Ser Gln  
2545                 2550                 2555                 2560 
Tyr Arg Val Glu Ser  Met Met Leu Arg Ile  Ala Lys Pro Met Asn  Tyr 
                2565                 2570                 2575     
Ile Pro Val Thr  Pro Ser Val Gln Gln  Arg Ser Gln Met Arg  Ala Pro 
            2580                 2585                 2590         
Gln Cys Val  Pro Leu Ile Met Glu  Pro Glu Ser Arg Phe  Tyr Ser Asn 
        2595                 2600                 2605             
Ser Val  Leu Val Leu Asp Phe  Gln Ser Leu Tyr Pro  Ser Ile Val Ile 
    2610                 2615                 2620                 
Ala  Tyr Asn Tyr Cys Phe  Ser Thr Cys Leu Gly  His Val Glu Asn Leu  
2625                 2630                 2635                 2640 
Gly Lys Tyr Asp Glu  Phe Lys Phe Gly Cys  Thr Ser Leu Arg Val  Pro 
                2645                 2650                 2655     
Pro Asp Leu Leu  Tyr Gln Val Arg His  Asp Ile Thr Val Ser  Pro Asn 
            2660                 2665                 2670         
Gly Val Ala  Phe Val Lys Pro Ser  Val Arg Lys Gly Val  Leu Pro Arg 
        2675                 2680                 2685             
Met Leu  Glu Glu Ile Leu Lys  Thr Arg Phe Met Val  Lys Gln Ser Met 
    2690                 2695                 2700                 
Lys  Ala Tyr Lys Gln Asp  Arg Ala Leu Ser Arg  Met Leu Asp Ala Arg  
2705                 2710                 2715                 2720 
Gln Leu Gly Leu Lys  Leu Ile Ala Asn Val  Thr Phe Gly Tyr Thr  Ser 
                2725                 2730                 2735     
Ala Asn Phe Ser  Gly Arg Met Pro Cys  Ile Glu Val Gly Asp  Ser Ile 
            2740                 2745                 2750         
Val His Lys  Ala Arg Glu Thr Leu  Glu Arg Ala Ile Lys  Leu Val Asn 
        2755                 2760                 2765             
Asp Thr  Lys Lys Trp Gly Ala  Arg Val Val Tyr Gly  Asp Thr Asp Ser 
    2770                 2775                 2780                 
Met  Phe Val Leu Leu Lys  Gly Ala Thr Lys Glu  Gln Ser Phe Lys Ile  
2785                 2790                 2795                 2800 
Gly Gln Glu Ile Ala  Glu Ala Val Thr Ala  Thr Asn Pro Lys Pro  Val 
                2805                 2810                 2815     
Lys Leu Lys Phe  Glu Lys Val Tyr Leu  Pro Cys Val Leu Gln  Thr Lys 
            2820                 2825                 2830         
Lys Arg Tyr  Val Gly Tyr Met Tyr  Glu Thr Leu Asp Gln  Lys Asp Pro 
        2835                 2840                 2845             
Val Phe  Asp Ala Lys Gly Ile  Glu Thr Val Arg Arg  Asp Ser Cys Pro 
    2850                 2855                 2860                 
Ala  Val Ser Lys Ile Leu  Glu Arg Ser Leu Lys  Leu Leu Phe Glu Thr  
2865                 2870                 2875                 2880 
Arg Asp Ile Ser Leu  Ile Lys Gln Tyr Val  Gln Arg Gln Cys Met  Lys 
                2885                 2890                 2895     
Leu Leu Glu Gly  Lys Ala Ser Ile Gln  Asp Phe Ile Phe Ala  Lys Glu 
            2900                 2905                 2910         
Tyr Arg Gly  Ser Phe Ser Tyr Lys  Pro Gly Ala Cys Val  Pro Ala Leu 
        2915                 2920                 2925             
Glu Leu  Thr Arg Lys Met Leu  Thr Tyr Asp Arg Arg  Ser Glu Pro Gln 
    2930                 2935                 2940                 
Val  Gly Glu Arg Val Pro  Tyr Val Ile Ile Tyr  Gly Thr Pro Gly Val  
2945                 2950                 2955                 2960 
Pro Leu Ile Gln Leu  Val Arg Arg Pro Val  Glu Val Leu Gln Asp  Pro 
                2965                 2970                 2975     
Thr Leu Arg Leu  Asn Ala Thr Tyr Tyr  Ile Thr Lys Gln Ile  Leu Pro 
            2980                 2985                 2990         
Pro Leu Ala  Arg Ile Phe Ser Leu  Ile Gly Ile Asp Val  Phe Ser Trp 
        2995                 3000                 3005             
Tyr His  Glu Leu Pro Arg Ile  His Lys Ala Thr Ser  Ser Ser Arg Ser 
    3010                 3015                 3020                 
Glu  Pro Glu Gly Arg Lys  Gly Thr Ile Ser Gln  Tyr Phe Thr Thr Leu  
3025                 3030                 3035                 3040 
His Cys Pro Val Cys  Asp Asp Leu Thr Gln  His Gly Ile Cys Ser  Lys 
                3045                 3050                 3055     
Cys Arg Ser Gln  Pro Gln His Val Ala  Val Ile Leu Asn Gln  Glu Ile 
            3060                 3065                 3070         
Arg Glu Leu  Glu Arg Gln Gln Glu  Gln Leu Val Lys Ile  Cys Lys Asn 
        3075                 3080                 3085             
Cys Thr  Gly Cys Phe Asp Arg  His Ile Pro Cys Val  Ser Leu Asn Cys 
    3090                 3095                 3100                 
Pro  Val Leu Phe Lys Leu  Ser Arg Val Asn Arg  Glu Leu Ser Lys Ala  
3105                 3110                 3115                 3120 
Pro Tyr Leu Arg Gln  Leu Leu Asp Gln Phe  
                3125                 3130 

<210>  3
<211>  420
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Met Thr Met Glu Lys Gly Met Ser Ser Gly Glu Gly Leu Pro Ser Arg 
1               5                   10                  15      
Ser Ser Gln Val Ser Ala Gly Lys Ile Thr Ala Lys Glu Leu Glu Thr 
            20                  25                  30          
Lys Gln Ser Tyr Lys Glu Lys Arg Gly Gly Phe Val Leu Val His Ala 
        35                  40                  45              
Gly Ala Gly Tyr His Ser Glu Ser Lys Ala Lys Glu Tyr Lys His Val 
    50                  55                  60                  
Cys Lys Arg Ala Cys Gln Lys Ala Ile Glu Lys Leu Gln Ala Gly Ala 
65                  70                  75                  80  
Leu Ala Thr Asp Ala Val Thr Ala Ala Leu Val Glu Leu Glu Asp Ser 
                85                  90                  95      
Pro Phe Thr Asn Ala Gly Met Gly Ser Asn Leu Asn Leu Leu Gly Glu 
            100                 105                 110         
Ile Glu Cys Asp Ala Ser Ile Met Asp Gly Lys Ser Leu Asn Phe Gly 
        115                 120                 125             
Ala Val Gly Ala Leu Ser Gly Ile Lys Asn Pro Val Ser Val Ala Asn 
    130                 135                 140                 
Arg Leu Leu Cys Glu Gly Gln Lys Gly Lys Leu Ser Ala Gly Arg Ile 
145                 150                 155                 160 
Pro Pro Cys Phe Leu Val Gly Glu Gly Ala Tyr Arg Trp Ala Val Asp 
                165                 170                 175     
His Gly Ile Pro Ser Cys Pro Pro Asn Ile Met Thr Thr Arg Phe Ser 
            180                 185                 190         
Leu Ala Ala Phe Lys Arg Asn Lys Arg Lys Leu Glu Leu Ala Glu Arg 
        195                 200                 205             
Val Asp Thr Asp Phe Met Gln Leu Lys Lys Arg Arg Gln Ser Ser Glu 
    210                 215                 220                 
Lys Glu Asn Asp Ser Gly Thr Leu Asp Thr Val Gly Ala Val Val Val 
225                 230                 235                 240 
Asp His Glu Gly Asn Val Ala Ala Ala Val Ser Ser Gly Gly Leu Ala 
                245                 250                 255     
Leu Lys His Pro Gly Arg Val Gly Gln Ala Ala Leu Tyr Gly Cys Gly 
            260                 265                 270         
Cys Trp Ala Glu Asn Thr Gly Ala His Asn Pro Tyr Ser Thr Ala Val 
        275                 280                 285             
Ser Thr Ser Gly Cys Gly Glu His Leu Val Arg Thr Ile Leu Ala Arg 
    290                 295                 300                 
Glu Cys Ser His Ala Leu Gln Ala Glu Asp Ala His Gln Ala Leu Leu 
305                 310                 315                 320 
Glu Thr Met Gln Asn Lys Phe Ile Ser Ser Pro Phe Leu Ala Ser Glu 
                325                 330                 335     
Asp Gly Val Leu Gly Gly Val Ile Val Leu Arg Ser Cys Arg Cys Ser 
            340                 345                 350         
Ala Glu Pro Asp Ser Ser Gln Asn Lys Gln Thr Leu Leu Val Glu Phe 
        355                 360                 365             
Leu Trp Ser His Thr Thr Glu Ser Met Cys Val Gly Tyr Met Ser Ala 
    370                 375                 380                 
Gln Asp Gly Lys Ala Lys Thr His Ile Ser Arg Leu Pro Pro Gly Ala 
385                 390                 395                 400 
Val Ala Gly Gln Ser Val Ala Ile Glu Gly Gly Val Cys Arg Leu Glu 
                405                 410                 415     
Ser Pro Val Asn 
            420 

<210>  4
<211>  2368
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  4
gggtgactac ttccggtgca gtgaaggctc ggggctgaag cggggtaatt cctctcctgc        60
aattactttt ggatggaagt atgccccttt ctcagtagaa gatggtaatc ttggagaatg       120
accatggaga aggggatgag ttctggagaa gggctgcctt ccagatcatc tcaggtttcg       180
gctggtaaaa taacagccaa agagttggaa acaaagcagt cctataaaga gaaacgagga       240
ggctttgtgt tggtgcatgc aggtgcaggt tatcattctg aatccaaagc caaggagtat       300
aaacatgtat gcaaacgagc ttgtcagaag gcaattgaaa agctgcaggc cggtgctctt       360
gcaactgacg cagtcactgc agcactggtg gaacttgagg attctccttt tacaaatgca       420
ggaatgggat ctaatctaaa tctgttaggt gaaattgagt gtgatgccag cataatggat       480
ggaaaatcct taaattttgg agcagttgga gcactgagtg gaatcaagaa cccagtctcg       540
gttgccaaca gactcttatg tgaagggcag aagggcaagc tctcggctgg cagaattcct       600
ccctgctttt tagttggaga aggagcctac agatgggcag tagatcatgg aataccctct       660
tgccctccta acatcatgac cacaagattc agtttagctg catttaaaag aaacaagagg       720
aaactagagc tggcagaaag ggtggacaca gattttatgc aactaaagaa aagaagacaa       780
tcaagtgaga aggaaaatga ctcaggcact ttggacacgg taggcgctgt ggttgtggac       840
cacgaaggga atgttgctgc tgctgtctcc agtggaggct tggccttgaa acatccgggg       900
agagttgggc aggctgctct ttatggatgt ggctgctggg ctgaaaatac tggagctcat       960
aacccctact ccacagctgt gagtacctca ggatgtggag agcatcttgt gcgcaccata      1020
ctggctagag aatgttcaca tgctttacaa gctgaggatg ctcaccaagc cctgttggag      1080
actatgcaaa acaagtttat cagttcacct ttccttgcca gtgaagatgg cgtgcttggc      1140
ggagtgattg tcctccgttc atgcagatgt tctgccgagc ctgactcctc ccaaaataag      1200
cagacacttc tagtggaatt tctgtggagc cacacgacgg agagcatgtg tgtcggatat      1260
atgtcagccc aggatgggaa agccaagact cacatttcaa gacttcctcc tggtgcggtg      1320
gcaggacagt ctgtggcaat cgaaggtggg gtgtgccgcc tggagagccc agtgaactga      1380
cccttcaggc tgagtgtgaa gcgtctcaga ggcatttcag aacctgagct tttgggggtt      1440
tttaactgaa gttggttgtt ttatctttct tgttttataa ttcctattgc aacctcgtgc      1500
actgctcgag acacaagtgc tgctgtagtt agcgcttagt gacacgcggg cctttggtgg      1560
gtgagcggga ctgtgtgtga gtgtgtgcgc gtatgtgcgc acatatgtgt atgtgtggag      1620
tatgtgtgtt tgcttctccg tggatgaaat agaaactcct cattgtgtga ccaggaatgg      1680
ttaaatcatc tttacaaaat gtgtgcttta actgtttaca agtaaaacct aaagttgcag      1740
gaaacatttt ttatttcgta aagaggtacc aactgtcgct gatgtgatat gtcagaactg      1800
aagagtaaat ctacttgttt aaatgacttg acagtggtag tgctccattt aataacagta      1860
ataagtaata aagtgttttt atttgttaac cagtttaagt ggatcctgtg gtaacttaaa      1920
ctgttgttct catcccttat atggggcatt tttctttaac aaagaatggt ttcagtgaaa      1980
caatctagca gagaattaat gtcagaacct ttttaaataa tagtctgatt gatacagttt      2040
gtacttattt catcaagctt ttctaagctt aaatattgca tagcttcgag ctgtatggac      2100
tatattatga aagaatatgt aaagagaaca tacagtaatg cacagtcctt aatttgtgta      2160
taatggaaag ttatttacaa tataacactg taaataagaa agcaaagttt atgggaaaat      2220
tcaatattat ctttgttttt gtttaaatat atttttaaga taaaggcaca aaaataaaag      2280
aagcgtatta ctgggtatag tatgtgactc ctcttctcag actaataaat tatcttttga      2340
atccttggtt aaaaaaaaaa aaaaaaaa                                         2368

<210>  5
<211>  525
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Met Phe Ser Val Arg Ile Val Thr Ala Asp Tyr Tyr Met Ala Ser Pro 
1               5                   10                  15      
Leu Gln Gly Leu Asp Thr Cys Gln Ser Pro Leu Thr Gln Ala Pro Val 
            20                  25                  30          
Lys Lys Val Pro Val Val Arg Val Phe Gly Ala Thr Pro Ala Gly Gln 
        35                  40                  45              
Lys Thr Cys Leu His Leu His Gly Ile Phe Pro Tyr Leu Tyr Val Pro 
    50                  55                  60                  
Tyr Asp Gly Tyr Gly Gln Gln Pro Glu Ser Tyr Leu Ser Gln Met Ala 
65                  70                  75                  80  
Phe Ser Ile Asp Arg Ala Leu Asn Val Ala Leu Gly Asn Pro Ser Ser 
                85                  90                  95      
Thr Ala Gln His Val Phe Lys Val Ser Leu Val Ser Gly Met Pro Phe 
            100                 105                 110         
Tyr Gly Tyr His Glu Lys Glu Arg His Phe Met Lys Ile Tyr Leu Tyr 
        115                 120                 125             
Asn Pro Thr Met Val Lys Arg Ile Cys Glu Leu Leu Gln Ser Gly Ala 
    130                 135                 140                 
Ile Met Asn Lys Phe Tyr Gln Pro His Glu Ala His Ile Pro Tyr Leu 
145                 150                 155                 160 
Leu Gln Leu Phe Ile Asp Tyr Asn Leu Tyr Gly Met Asn Leu Ile Asn 
                165                 170                 175     
Leu Ala Ala Val Lys Phe Arg Lys Ala Arg Arg Lys Ser Asn Thr Leu 
            180                 185                 190         
His Ala Thr Gly Ser Cys Lys Asn His Leu Ser Gly Asn Ser Leu Ala 
        195                 200                 205             
Asp Thr Leu Phe Arg Trp Glu Gln Asp Glu Ile Pro Ser Ser Leu Ile 
    210                 215                 220                 
Leu Glu Gly Val Glu Pro Gln Ser Thr Cys Glu Leu Glu Val Asp Ala 
225                 230                 235                 240 
Val Ala Ala Asp Ile Leu Asn Arg Leu Asp Ile Glu Ala Gln Ile Gly 
                245                 250                 255     
Gly Asn Pro Gly Leu Gln Ala Ile Trp Glu Asp Glu Lys Gln Arg Arg 
            260                 265                 270         
Arg Asn Arg Asn Glu Thr Ser Gln Met Ser Gln Pro Glu Ser Gln Asp 
        275                 280                 285             
His Arg Phe Val Pro Ala Thr Glu Ser Glu Lys Lys Phe Gln Lys Arg 
    290                 295                 300                 
Leu Gln Glu Ile Leu Lys Gln Asn Asp Phe Ser Val Thr Leu Ser Gly 
305                 310                 315                 320 
Ser Val Asp Tyr Ser Asp Gly Ser Gln Glu Phe Ser Ala Glu Leu Thr 
                325                 330                 335     
Leu His Ser Glu Val Leu Ser Pro Glu Met Leu Gln Cys Thr Pro Ala 
            340                 345                 350         
Asn Met Val Glu Val His Lys Asp Lys Glu Ser Ser Lys Gly His Thr 
        355                 360                 365             
Arg His Lys Val Glu Glu Ala Leu Ile Asn Glu Glu Ala Ile Leu Asn 
    370                 375                 380                 
Leu Met Glu Asn Ser Gln Thr Phe Gln Pro Leu Thr Gln Arg Leu Ser 
385                 390                 395                 400 
Glu Ser Pro Val Phe Met Asp Ser Ser Pro Asp Glu Ala Leu Val His 
                405                 410                 415     
Leu Leu Ala Gly Leu Glu Ser Asp Gly Tyr Arg Gly Glu Arg Asn Arg 
            420                 425                 430         
Met Pro Ser Pro Cys Arg Ser Phe Gly Asn Asn Lys Tyr Pro Gln Asn 
        435                 440                 445             
Ser Asp Asp Glu Glu Asn Glu Pro Gln Ile Glu Lys Glu Glu Met Glu 
    450                 455                 460                 
Leu Ser Leu Val Met Ser Gln Arg Trp Asp Ser Asn Ile Glu Glu His 
465                 470                 475                 480 
Cys Ala Lys Lys Arg Ser Leu Cys Arg Asn Thr His Arg Ser Ser Thr 
                485                 490                 495     
Glu Asp Asp Asp Ser Ser Ser Gly Glu Glu Met Glu Trp Ser Asp Asn 
            500                 505                 510         
Ser Leu Leu Leu Ala Ser Leu Ser Ile Pro Gln Leu Asp 
        515                 520                 525 

