                         SEQUENCE LISTING

<110>  Beijing Mabworks Biotech Co., Ltd
 
<120>  ANTIBODIES BINDING OX40 AND USES THEREOF

<130>  55566 00013

<150>  US16/254,624
<151>  2019-01-23

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  71H8.68C8-HV-CDR1

<400>  1

Ser Tyr Trp Ile Thr 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6A12-HV-CDR1

<400>  2

Ser Ser Trp Met Asn 
1               5   


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  71H8-HV-CDR2

<400>  3

Asp Ile Tyr Pro Gly Ser Gly Ser Thr Asn Gln Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  68C8-HV-CDR2

<400>  4

Asp Ile His Pro Gly Ser Gly Ser Thr Asn Asn Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6A12-HV-CDR2

<400>  5

Arg Ile Tyr Pro Gly Asp Gly Ile Thr Asn Tyr Asn Gly Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  71H8, 68C8-HV-CDR3

<400>  6

Leu Arg Pro Tyr Tyr Phe Val Tyr 
1               5               


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6A12-HV-CDR3

<400>  7

Glu Phe Ile Pro Leu Gly 
1               5       


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  71H8, 68C8-LV-CDR1

<400>  8

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6A12-LV-CDR1

<400>  9

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  71H8, 68C8-LV-CDR2

<400>  10

Tyr Thr Ser Arg Leu Leu Ser 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6A12-LV-CDR2

<400>  11

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  71H8, 68C8-LV-CDR3

<400>  12

Gln Gln Gly Asn Thr Leu Pro Leu Thr 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6A12-LV-CDR3

<400>  13

Ala Gln Asn Leu Glu Leu Pro Trp Thr 
1               5                   


<210>  14
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  71H8-HV

<400>  14

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Ser Thr Asn Gln Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Arg Pro Tyr Tyr Phe Val Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  15
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  68C8-HV

<400>  15

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Asp Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile His Pro Gly Ser Gly Ser Thr Asn Asn Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Arg Pro Tyr Tyr Phe Val Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  16
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6A12-HV

<400>  16

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Ile Thr Asn Tyr Asn Gly Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Ala Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Phe Ile Pro Leu Gly Trp Gly Thr Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  17
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  68C8-VH0

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Asp Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile His Pro Gly Ser Gly Ser Thr Asn Asn Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Arg Pro Tyr Tyr Phe Val Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  18
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  68C8-VH2

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Asp Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Arg Gln Arg Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile His Pro Gly Ser Gly Ser Thr Asn Asn Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Met Thr Val Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Arg Pro Tyr Tyr Phe Val Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  19
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  68C8-VH3

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Asp Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile His Pro Gly Ser Gly Ser Thr Asn Asn Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Val Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Arg Pro Tyr Tyr Phe Val Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  20
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  71H8-VH0

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Asp Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Ser Thr Asn Gln Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Arg Pro Tyr Tyr Phe Val Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  21
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  71H8-VH2

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Arg Gln Arg Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Ser Thr Asn Gln Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Thr Val Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Arg Pro Tyr Tyr Phe Val Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  22
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  71H8-VH3

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Ser Thr Asn Gln Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Leu Thr Val Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Arg Pro Tyr Tyr Phe Val Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  23
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  71H8-VL

<400>  23

Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  24
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  68C8-VL

<400>  24

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Arg Leu Glu Leu Lys 
            100                 105         


<210>  25
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6A12-VL

<400>  25

Asp Ile Val Met Thr Gln Thr Pro Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  26
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  68C8, 71H8-LV0

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  68C8, 71H8-VL2

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  28
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  68C8, 71H8-VL3

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  29
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH

<400>  29

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  30
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CL

<400>  30

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  31
<211>  834
<212>  DNA
<213>  Homo sapiens

<400>  31
atgtgcgtgg gcgcccgccg cctgggccgc ggcccctgcg ccgccctgct gctgctgggc       60

ctgggcctga gcaccgtgac cggcctgcac tgcgtgggcg acacctaccc cagcaacgac      120

cgctgctgcc acgagtgccg ccccggcaac ggcatggtga gccgctgcag ccgcagccag      180

aacaccgtgt gccgcccctg cggccccggc ttctacaacg acgtggtgag cagcaagccc      240

tgcaagccct gcacctggtg caacctgcgc agcggcagcg agcgcaagca gctgtgcacc      300

gccacccagg acaccgtgtg ccgctgccgc gccggcaccc agcccctgga cagctacaag      360

cccggcgtgg actgcgcccc ctgccccccc ggccacttca gccccggcga caaccaggcc      420

tgcaagccct ggaccaactg caccctggcc ggcaagcaca ccctgcagcc cgccagcaac      480

agcagcgacg ccatctgcga ggaccgcgac ccccccgcca cccagcccca ggagacccag      540

ggcccccccg cccgccccat caccgtgcag cccaccgagg cctggccccg caccagccag      600

ggccccagca cccgccccgt ggaggtgccc ggcggccgcg ccgtggccgc catcctgggc      660

ctgggcctgg tgctgggcct gctgggcccc ctggccatcc tgctggccct gtacctgctg      720

cgccgcgacc agcgcctgcc ccccgacgcc cacaagcccc ccggcggcgg cagcttccgc      780

acccccatcc aggaggagca ggccgacgcc cacagcaccc tggccaagat ctaa            834


<210>  32
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  33
<211>  834
<212>  DNA
<213>  Macaca mulatta

<400>  33
atgtgcgtgg gcgcccgccg cctgggccgc ggcccctgcg ccgccctgct gctgctgggc       60

ctgggcctga gcaccaccgc caagctgcac tgcgtgggcg acacctaccc cagcaacgac      120

cgctgctgcc aggagtgccg ccccggcaac ggcatggtga gccgctgcaa ccgcagccag      180

aacaccgtgt gccgcccctg cggccccggc ttctacaacg acgtggtgag cgccaagccc      240

tgcaaggcct gcacctggtg caacctgcgc agcggcagcg agcgcaagca gccctgcacc      300

gccacccagg acaccgtgtg ccgctgccgc gccggcaccc agcccctgga cagctacaag      360

cccggcgtgg actgcgcccc ctgccccccc ggccacttca gccccggcga caaccaggcc      420

tgcaagccct ggaccaactg caccctggcc ggcaagcaca ccctgcagcc cgccagcaac      480

agcagcgacg ccatctgcga ggaccgcgac ccccccccca cccagcccca ggagacccag      540

ggcccccccg cccgccccac caccgtgcag cccaccgagg cctggccccg caccagccag      600

cgccccagca cccgccccgt ggaggtgccc cgcggccccg ccgtggccgc catcctgggc      660

ctgggcctgg ccctgggcct gctgggcccc ctggccatgc tgctggccct gctgctgctg      720

cgccgcgacc agcgcctgcc ccccgacgcc cccaaggccc ccggcggcgg cagcttccgc      780

acccccatcc aggaggagca ggccgacgcc cacagcgccc tggccaagat ctaa            834


<210>  34
<211>  277
<212>  PRT
<213>  Macaca mulatta

<400>  34

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Thr Ala Lys Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys Gln Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Asn Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ala Lys Pro 
65                  70                  75                  80  


Cys Lys Ala Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Pro Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Pro Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Thr Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Arg Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Arg Gly Pro Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Ala 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Met Leu Leu Ala Leu Leu Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala Pro Lys Ala Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Ala Leu Ala Lys Ile 
        275         


<210>  35
<211>  819
<212>  DNA
<213>  Mus musculus

<400>  35
atgtacgtgt gggtgcagca gcccaccgcc ctgctgctgc tgggcctgac cctgggcgtg       60

accgcccgcc gcctgaactg cgtgaagcac acctacccca gcggccacaa gtgctgccgc      120

gagtgccagc ccggccacgg catggtgagc cgctgcgacc acacccgcga caccctgtgc      180

cacccctgcg agaccggctt ctacaacgag gccgtgaact acgacacctg caagcagtgc      240

acccagtgca accaccgcag cggcagcgag ctgaagcaga actgcacccc cacccaggac      300

accgtgtgcc gctgccgccc cggcacccag ccccgccagg acagcggcta caagctgggc      360

gtggactgcg tgccctgccc ccccggccac ttcagccccg gcaacaacca ggcctgcaag      420

ccctggacca actgcaccct gagcggcaag cagacccgcc accccgccag cgacagcctg      480

gacgccgtgt gcgaggaccg cagcctgctg gccaccctgc tgtgggagac ccagcgcccc      540

accttccgcc ccaccaccgt gcagagcacc accgtgtggc cccgcaccag cgagctgccc      600

agccccccca ccctggtgac ccccgagggc cccgccttcg ccgtgctgct gggcctgggc      660

ctgggcctgc tggcccccct gaccgtgctg ctggccctgt acctgctgcg caaggcctgg      720

cgcctgccca acacccccaa gccctgctgg ggcaacagct tccgcacccc catccaggag      780

gagcacaccg acgcccactt caccctggcc aagatctaa                             819


<210>  36
<211>  272
<212>  PRT
<213>  Mus musculus

<400>  36

Met Tyr Val Trp Val Gln Gln Pro Thr Ala Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Thr Leu Gly Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr 
            20                  25                  30          


Pro Ser Gly His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met 
        35                  40                  45              


Val Ser Arg Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu 
    50                  55                  60                  


Thr Gly Phe Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys 
65                  70                  75                  80  


Thr Gln Cys Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr 
                85                  90                  95      


Pro Thr Gln Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg 
            100                 105                 110         


Gln Asp Ser Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro 
        115                 120                 125             


Gly His Phe Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn 
    130                 135                 140                 


Cys Thr Leu Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu 
145                 150                 155                 160 


Asp Ala Val Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu 
                165                 170                 175     


Thr Gln Arg Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val 
            180                 185                 190         


Trp Pro Arg Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro 
        195                 200                 205             


Glu Gly Pro Ala Phe Ala Val Leu Leu Gly Leu Gly Leu Gly Leu Leu 
    210                 215                 220                 


Ala Pro Leu Thr Val Leu Leu Ala Leu Tyr Leu Leu Arg Lys Ala Trp 
225                 230                 235                 240 


Arg Leu Pro Asn Thr Pro Lys Pro Cys Trp Gly Asn Ser Phe Arg Thr 
                245                 250                 255     


Pro Ile Gln Glu Glu His Thr Asp Ala His Phe Thr Leu Ala Lys Ile 
            260                 265                 270         


<210>  37
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human OX40-CD40 fusion protein

<400>  37

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Ala Leu Val Val Ile Pro Ile Ile Phe Gly 
    210                 215                 220                 


Ile Leu Phe Ala Ile Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala 
225                 230                 235                 240 


Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu 
                245                 250                 255     


Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val 
            260                 265                 270         


Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys 
        275                 280                 285             


Glu Ser Arg Ile Ser Val 
    290                 


<210>  38
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full length OX40-ECD

<400>  38

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg 
            20                  25                  30          


Cys Cys His Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Ser 
        35                  40                  45              


Arg Ser Gln Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn 
    50                  55                  60                  


Asp Val Val Ser Ser Lys Pro Cys Lys Pro Cys Thr Trp Cys Asn Leu 
65                  70                  75                  80  


Arg Ser Gly Ser Glu Arg Lys Gln Leu Cys Thr Ala Thr Gln Asp Thr 
                85                  90                  95      


Val Cys Arg Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro 
            100                 105                 110         


Gly Val Asp Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp 
        115                 120                 125             


Asn Gln Ala Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His 
    130                 135                 140                 


Thr Leu Gln Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg 
145                 150                 155                 160 


Asp Pro Pro Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg 
                165                 170                 175     


Pro Ile Thr Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly 
            180                 185                 190         


Pro Ser Thr Arg Pro Val Glu Val Pro Gly Gly Arg Ala Ala Lys Thr 
        195                 200                 205             


Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr 
    210                 215                 220                 


Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu 
225                 230                 235                 240 


Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His 
                245                 250                 255     


Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser 
            260                 265                 270         


Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn 
        275                 280                 285             


Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro 
    290                 295                 300                 


Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser 
305                 310                 315                 320 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr 
                325                 330                 335     


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp 
            340                 345                 350         


Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr 
        355                 360                 365             


Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser 
    370                 375                 380                 


Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys 
                405                 410                 415     


Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr 
            420                 425                 430         


Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr 
        435                 440                 445             


Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln 
    450                 455                 460                 


Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met 
465                 470                 475                 480 


Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys 
                485                 490                 495     


Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu 
            500                 505                 510         


Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly 
        515                 520                 525             


Lys 
    


<210>  39
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40 truncant 1-mFc

<400>  39

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser 
            20                  25                  30          


Lys Pro Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu 
        35                  40                  45              


Arg Lys Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg 
    50                  55                  60                  


Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala 
65                  70                  75                  80  


Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys 
                85                  90                  95      


Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala 
            100                 105                 110         


Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr 
        115                 120                 125             


Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln 
    130                 135                 140                 


Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro 
145                 150                 155                 160 


Val Glu Val Pro Gly Gly Arg Ala Ala Lys Thr Thr Pro Pro Ser Val 
                165                 170                 175     


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
            180                 185                 190         


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
        195                 200                 205             


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
    210                 215                 220                 


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
225                 230                 235                 240 


Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
                245                 250                 255     


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys 
            260                 265                 270         


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
        275                 280                 285             


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
    290                 295                 300                 


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
305                 310                 315                 320 


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
                325                 330                 335     


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
            340                 345                 350         


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
        355                 360                 365             


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
    370                 375                 380                 


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
385                 390                 395                 400 


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
                405                 410                 415     


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
            420                 425                 430         


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
        435                 440                 445             


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
    450                 455                 460                 


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
465                 470                 475                 480 


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
                485                 490         


<210>  40
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40 truncant 2-mFc

<400>  40

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Arg Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys 
            20                  25                  30          


Pro Gly Val Asp Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly 
        35                  40                  45              


Asp Asn Gln Ala Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys 
    50                  55                  60                  


His Thr Leu Gln Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp 
65                  70                  75                  80  


Arg Asp Pro Pro Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala 
                85                  90                  95      


Arg Pro Ile Thr Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln 
            100                 105                 110         


Gly Pro Ser Thr Arg Pro Val Glu Val Pro Gly Gly Arg Ala Ala Lys 
        115                 120                 125             


Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln 
    130                 135                 140                 


Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser 
            180                 185                 190         


Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys 
        195                 200                 205             


Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val 
    210                 215                 220                 


Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val 
225                 230                 235                 240 


Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile 
                245                 250                 255     


Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His 
        275                 280                 285             


Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
    290                 295                 300                 


Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr 
            340                 345                 350         


Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu 
        355                 360                 365             


Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp 
    370                 375                 380                 


Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile 
385                 390                 395                 400 


Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln 
                405                 410                 415     


Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His 
            420                 425                 430         


Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  41
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OX40 truncant 3-mFc

<400>  41

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln 
            20                  25                  30          


Ala Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu 
        35                  40                  45              


Gln Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro 
    50                  55                  60                  


Pro Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile 
65                  70                  75                  80  


Thr Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser 
                85                  90                  95      


Thr Arg Pro Val Glu Val Pro Gly Gly Arg Ala Ala Lys Thr Thr Pro 
            100                 105                 110         


Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 
        115                 120                 125             


Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
    130                 135                 140                 


Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
145                 150                 155                 160 


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
                165                 170                 175     


Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala 
            180                 185                 190         


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 
        195                 200                 205             


Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 
    210                 215                 220                 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
225                 230                 235                 240 


Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu 
                245                 250                 255     


Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
            260                 265                 270         


Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
        275                 280                 285             


Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys 
    290                 295                 300                 


Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile 
305                 310                 315                 320 


Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro 
                325                 330                 335     


Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met 
            340                 345                 350         


Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn 
        355                 360                 365             


Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr 
    370                 375                 380                 


Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn 
385                 390                 395                 400 


Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
                405                 410                 415     


His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
            420                 425                 430     


<210>  42
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  42

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  43
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mFc-tag

<400>  43

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


