                         SEQUENCE LISTING

<110>  The General Hospital Corporation
       The Regents of the University of California
       Luis Barreiro
 
<120>  METHODS AND COMPOSITIONS FOR MODULATING IMMUNE DYSREGULATION

<130>  51363-002WO5

<150>  US 62/930,813
<151>  2019-11-05

<150>  US 62/794,386
<151>  2019-01-18

<160>  266   

<170>  PatentIn version 3.5

<210>  1
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Glu Val Glu Ile Ser Ala Leu Ala Tyr Val Lys Met Cys Leu 
1               5                   10                  15      


His Ala Ala Arg Tyr Pro His Ala Ala Val Asn Gly Leu Phe Leu Ala 
            20                  25                  30          


Pro Ala Pro Arg Ser Gly Glu Cys Leu Cys Leu Thr Asp Cys Val Pro 
        35                  40                  45              


Leu Phe His Ser His Leu Ala Leu Ser Val Met Leu Glu Val Ala Leu 
    50                  55                  60                  


Asn Gln Val Asp Val Trp Gly Ala Gln Ala Gly Leu Val Val Ala Gly 
65                  70                  75                  80  


Tyr Tyr His Ala Asn Ala Ala Val Asn Asp Gln Ser Pro Gly Pro Leu 
                85                  90                  95      


Ala Leu Lys Ile Ala Gly Arg Ile Ala Glu Phe Phe Pro Asp Ala Val 
            100                 105                 110         


Leu Ile Met Leu Asp Asn Gln Lys Leu Val Pro Gln Pro Arg Val Pro 
        115                 120                 125             


Pro Val Ile Val Leu Glu Asn Gln Gly Leu Arg Trp Val Pro Lys Asp 
    130                 135                 140                 


Lys Asn Leu Val Met Trp Arg Asp Trp Glu Glu Ser Arg Gln Met Val 
145                 150                 155                 160 


Gly Ala Leu Leu Glu Asp Arg Ala His Gln His Leu Val Asp Phe Asp 
                165                 170                 175     


Cys His Leu Asp Asp Ile Arg Gln Asp Trp Thr Asn Gln Arg Leu Asn 
            180                 185                 190         


Thr Gln Ile Thr Gln Trp Val Gly Pro Thr Asn Gly Asn Gly Asn Ala 
        195                 200                 205             


<210>  2
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asn Lys Pro Ile Thr Pro Ser Thr Tyr Val Arg Cys Leu Asn Val 
1               5                   10                  15      


Gly Leu Ile Arg Lys Leu Ser Asp Phe Ile Asp Pro Gln Glu Gly Trp 
            20                  25                  30          


Lys Lys Leu Ala Val Ala Ile Lys Lys Pro Ser Gly Asp Asp Arg Tyr 
        35                  40                  45              


Asn Gln Phe His Ile Arg Arg Phe Glu Ala Leu Leu Gln Thr Gly Lys 
    50                  55                  60                  


Ser Pro Thr Ser Glu Leu Leu Phe Asp Trp Gly Thr Thr Asn Cys Thr 
65                  70                  75                  80  


Val Gly Asp Leu Val Asp Leu Leu Ile Gln Asn Glu Phe Phe Ala Pro 
                85                  90                  95      


Ala Ser Leu Leu Leu Pro Asp Ala Val Pro Lys Thr Ala Asn Thr Leu 
            100                 105                 110         


Pro Ser Lys Glu Ala Ile Thr Val Gln Gln Lys Gln Met Pro Phe Cys 
        115                 120                 125             


Asp Lys Asp Arg Thr Leu Met Thr Pro Val Gln Asn Leu Glu Gln Ser 
    130                 135                 140                 


Tyr Met Pro Pro Asp Ser Ser Ser Pro Glu Asn Lys Ser Leu Glu Val 
145                 150                 155                 160 


Ser Asp Thr Arg Phe His Ser Phe Ser Phe Tyr Glu Leu Lys Asn Val 
                165                 170                 175     


Thr Asn Asn Phe Asp Glu Arg Pro Ile Ser Val Gly Gly Asn Lys Met 
            180                 185                 190         


Gly Glu Gly Gly Phe Gly Val Val Tyr Lys Gly Tyr Val Asn Asn Thr 
        195                 200                 205             


Thr Val Ala Val Lys Lys Leu Ala Ala Met Val Asp Ile Thr Thr Glu 
    210                 215                 220                 


Glu Leu Lys Gln Gln Phe Asp Gln Glu Ile Lys Val Met Ala Lys Cys 
225                 230                 235                 240 


Gln His Glu Asn Leu Val Glu Leu Leu Gly Phe Ser Ser Asp Gly Asp 
                245                 250                 255     


Asp Leu Cys Leu Val Tyr Val Tyr Met Pro Asn Gly Ser Leu Leu Asp 
            260                 265                 270         


Arg Leu Ser Cys Leu Asp Gly Thr Pro Pro Leu Ser Trp His Met Arg 
        275                 280                 285             


Cys Lys Ile Ala Gln Gly Ala Ala Asn Gly Ile Asn Phe Leu His Glu 
    290                 295                 300                 


Asn His His Ile His Arg Asp Ile Lys Ser Ala Asn Ile Leu Leu Asp 
305                 310                 315                 320 


Glu Ala Phe Thr Ala Lys Ile Ser Asp Phe Gly Leu Ala Arg Ala Ser 
                325                 330                 335     


Glu Lys Phe Ala Gln Thr Val Met Thr Ser Arg Ile Val Gly Thr Thr 
            340                 345                 350         


Ala Tyr Met Ala Pro Glu Ala Leu Arg Gly Glu Ile Thr Pro Lys Ser 
        355                 360                 365             


Asp Ile Tyr Ser Phe Gly Val Val Leu Leu Glu Ile Ile Thr Gly Leu 
    370                 375                 380                 


Pro Ala Val Asp Glu His Arg Glu Pro Gln Leu Leu Leu Asp Ile Lys 
385                 390                 395                 400 


Glu Glu Ile Glu Asp Glu Glu Lys Thr Ile Glu Asp Tyr Ile Asp Lys 
                405                 410                 415     


Lys Met Asn Asp Ala Asp Ser Thr Ser Val Glu Ala Met Tyr Ser Val 
            420                 425                 430         


Ala Ser Gln Cys Leu His Glu Lys Lys Asn Lys Arg Pro Asp Ile Lys 
        435                 440                 445             


Lys Val Gln Gln Leu Leu Gln Glu Met Thr Ala Ser 
    450                 455                 460 


<210>  3
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Phe Cys Asp Lys Asp Arg Thr Leu Met Thr Pro Val Gln Asn 
1               5                   10                  15      


Leu Glu Gln Ser Tyr Met Pro Pro Asp Ser Ser Ser Pro Glu Asn Lys 
            20                  25                  30          


Ser Leu Glu Val Ser Asp Thr Arg Phe His Ser Phe Ser Phe Tyr Glu 
        35                  40                  45              


Leu Lys Asn Val Thr Asn Asn Phe Asp Glu Arg Pro Ile Ser Val Gly 
    50                  55                  60                  


Gly Asn Lys Met Gly Glu Gly Gly Phe Gly Val Val Tyr Lys Gly Tyr 
65                  70                  75                  80  


Val Asn Asn Thr Thr Val Ala Val Lys Lys Leu Ala Ala Met Val Asp 
                85                  90                  95      


Ile Thr Thr Glu Glu Leu Lys Gln Gln Phe Asp Gln Glu Ile Lys Val 
            100                 105                 110         


Met Ala Lys Cys Gln His Glu Asn Leu Val Glu Leu Leu Gly Phe Ser 
        115                 120                 125             


Ser Asp Gly Asp Asp Leu Cys Leu Val Tyr Val Tyr Met Pro Asn Gly 
    130                 135                 140                 


Ser Leu Leu Asp Arg Leu Ser Cys Leu Asp Gly Thr Pro Pro Leu Ser 
145                 150                 155                 160 


Trp His Met Arg Cys Lys Ile Ala Gln Gly Ala Ala Asn Gly Ile Asn 
                165                 170                 175     


Phe Leu His Glu Asn His His Ile His Arg Asp Ile Lys Ser Ala Asn 
            180                 185                 190         


Ile Leu Leu Asp Glu Ala Phe Thr Ala Lys Ile Ser Asp Phe Gly Leu 
        195                 200                 205             


Ala Arg Ala Ser Glu Lys Phe Ala Gln Thr Val Met Thr Ser Arg Ile 
    210                 215                 220                 


Val Gly Thr Thr Ala Tyr Met Ala Pro Glu Ala Leu Arg Gly Glu Ile 
225                 230                 235                 240 


Thr Pro Lys Ser Asp Ile Tyr Ser Phe Gly Val Val Leu Leu Glu Ile 
                245                 250                 255     


Ile Thr Gly Leu Pro Ala Val Asp Glu His Arg Glu Pro Gln Leu Leu 
            260                 265                 270         


Leu Asp Ile Lys Glu Glu Ile Glu Asp Glu Glu Lys Thr Ile Glu Asp 
        275                 280                 285             


Tyr Ile Asp Lys Lys Met Asn Asp Ala Asp Ser Thr Ser Val Glu Ala 
    290                 295                 300                 


Met Tyr Ser Val Ala Ser Gln Cys Leu His Glu Lys Lys Asn Lys Arg 
305                 310                 315                 320 


Pro Asp Ile Lys Lys Val Gln Gln Leu Leu Gln Glu Met Thr Ala Ser 
                325                 330                 335     


<210>  4
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Ala Pro Glu Arg Gln Pro Gln Pro Asp Gly Gly Asp Ala Pro 
1               5                   10                  15      


Gly His Glu Pro Gly Gly Ser Pro Gln Asp Glu Leu Asp Phe Ser Ile 
            20                  25                  30          


Leu Phe Asp Tyr Glu Tyr Leu Asn Pro Asn Glu Glu Glu Pro Asn Ala 
        35                  40                  45              


His Lys Val Ala Ser Pro Pro Ser Gly Pro Ala Tyr Pro Asp Asp Val 
    50                  55                  60                  


Leu Asp Tyr Gly Leu Lys Pro Tyr Ser Pro Leu Ala Ser Leu Ser Gly 
65                  70                  75                  80  


Glu Pro Pro Gly Arg Phe Gly Glu Pro Asp Arg Val Gly Pro Gln Lys 
                85                  90                  95      


Phe Leu Ser Ala Ala Lys Pro Ala Gly Ala Ser Gly Leu Ser Pro Arg 
            100                 105                 110         


Ile Glu Ile Thr Pro Ser His Glu Leu Ile Gln Ala Val Gly Pro Leu 
        115                 120                 125             


Arg Met Arg Asp Ala Gly Leu Leu Val Glu Gln Pro Pro Leu Ala Gly 
    130                 135                 140                 


Val Ala Ala Ser Pro Arg Phe Thr Leu Pro Val Pro Gly Phe Glu Gly 
145                 150                 155                 160 


Tyr Arg Glu Pro Leu Cys Leu Ser Pro Ala Ser Ser Gly Ser Ser Ala 
                165                 170                 175     


Ser Phe Ile Ser Asp Thr Phe Ser Pro Tyr Thr Ser Pro Cys Val Ser 
            180                 185                 190         


Pro Asn Asn Gly Gly Pro Asp Asp Leu Cys Pro Gln Phe Gln Asn Ile 
        195                 200                 205             


Pro Ala His Tyr Ser Pro Arg Thr Ser Pro Ile Met Ser Pro Arg Thr 
    210                 215                 220                 


Ser Leu Ala Glu Asp Ser Cys Leu Gly Arg His Ser Pro Val Pro Arg 
225                 230                 235                 240 


Pro Ala Ser Arg Ser Ser Ser Pro Gly Ala Lys Arg Arg His Ser Cys 
                245                 250                 255     


Ala Glu Ala Leu Val Ala Leu Pro Pro Gly Ala Ser Pro Gln Arg Ser 
            260                 265                 270         


Arg Ser Pro Ser Pro Gln Pro Ser Ser His Val Ala Pro Gln Asp His 
        275                 280                 285             


Gly Ser Pro Ala Gly Tyr Pro Pro Val Ala Gly Ser Ala Val Ile Met 
    290                 295                 300                 


Asp Ala Leu Asn Ser Leu Ala Thr Asp Ser Pro Cys Gly Ile Pro Pro 
305                 310                 315                 320 


Lys Met Trp Lys Thr Ser Pro Asp Pro Ser Pro Val Ser Ala Ala Pro 
                325                 330                 335     


Ser Lys Ala Gly Leu Pro Arg His Ile Tyr Pro Ala Val Glu Phe Leu 
            340                 345                 350         


Gly Pro Cys Glu Gln Gly Glu Arg Arg Asn Ser Ala Pro Glu Ser Ile 
        355                 360                 365             


Leu Leu Val Pro Pro Thr Trp Pro Lys Pro Leu Val Pro Ala Ile Pro 
    370                 375                 380                 


Ile Cys Ser Ile Pro Val Thr Ala Ser Leu Pro Pro Leu Glu Trp Pro 
385                 390                 395                 400 


Leu Ser Ser Gln Ser Gly Ser Tyr Glu Leu Arg Ile Glu Val Gln Pro 
                405                 410                 415     


Lys Pro His His Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala 
            420                 425                 430         


Val Lys Ala Pro Thr Gly Gly His Pro Val Val Gln Leu His Gly Tyr 
        435                 440                 445             


Met Glu Asn Lys Pro Leu Gly Leu Gln Ile Phe Ile Gly Thr Ala Asp 
    450                 455                 460                 


Glu Arg Ile Leu Lys Pro His Ala Phe Tyr Gln Val His Arg Ile Thr 
465                 470                 475                 480 


Gly Lys Thr Val Thr Thr Thr Ser Tyr Glu Lys Ile Val Gly Asn Thr 
                485                 490                 495     


Lys Val Leu Glu Ile Pro Leu Glu Pro Lys Asn Asn Met Arg Ala Thr 
            500                 505                 510         


Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn Ala Asp Ile Glu Leu 
        515                 520                 525             


Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu 
    530                 535                 540                 


Val Phe Arg Val His Ile Pro Glu Ser Ser Gly Arg Ile Val Ser Leu 
545                 550                 555                 560 


Gln Thr Ala Ser Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala His Glu 
                565                 570                 575     


Leu Pro Met Val Glu Arg Gln Asp Thr Asp Ser Cys Leu Val Tyr Gly 
            580                 585                 590         


Gly Gln Gln Met Ile Leu Thr Gly Gln Asn Phe Thr Ser Glu Ser Lys 
        595                 600                 605             


Val Val Phe Thr Glu Lys Thr Thr Asp Gly Gln Gln Ile Trp Glu Met 
    610                 615                 620                 


Glu Ala Thr Val Asp Lys Asp Lys Ser Gln Pro Asn Met Leu Phe Val 
625                 630                 635                 640 


Glu Ile Pro Glu Tyr Arg Asn Lys His Ile Arg Thr Pro Val Lys Val 
                645                 650                 655     


Asn Phe Tyr Val Ile Asn Gly Lys Arg Lys Arg Ser Gln Pro Gln His 
            660                 665                 670         


Phe Thr Tyr His Pro Val Pro Ala Ile Lys Thr Glu Pro Thr Asp Glu 
        675                 680                 685             


Tyr Asp Pro Thr Leu Ile Cys Ser Pro Thr His Gly Gly Leu Gly Ser 
    690                 695                 700                 


Gln Pro Tyr Tyr Pro Gln His Pro Met Val Ala Glu Ser Pro Ser Cys 
705                 710                 715                 720 


Leu Val Ala Thr Met Ala Pro Cys Gln Gln Phe Arg Thr Gly Leu Ser 
                725                 730                 735     


Ser Pro Asp Ala Arg Tyr Gln Gln Gln Asn Pro Ala Ala Val Leu Tyr 
            740                 745                 750         


Gln Arg Ser Lys Ser Leu Ser Pro Ser Leu Leu Gly Tyr Gln Gln Pro 
        755                 760                 765             


Ala Leu Met Ala Ala Pro Leu Ser Leu Ala Asp Ala His Arg Ser Val 
    770                 775                 780                 


Leu Val His Ala Gly Ser Gln Gly Gln Ser Ser Ala Leu Leu His Pro 
785                 790                 795                 800 


Ser Pro Thr Asn Gln Gln Ala Ser Pro Val Ile His Tyr Ser Pro Thr 
                805                 810                 815     


Asn Gln Gln Leu Arg Cys Gly Ser His Gln Glu Phe Gln His Ile Met 
            820                 825                 830         


Tyr Cys Glu Asn Phe Ala Pro Gly Thr Thr Arg Pro Gly Pro Pro Pro 
        835                 840                 845             


Val Ser Gln Gly Gln Arg Leu Ser Pro Gly Ser Tyr Pro Thr Val Ile 
    850                 855                 860                 


Gln Gln Gln Asn Ala Thr Ser Gln Arg Ala Ala Lys Asn Gly Pro Pro 
865                 870                 875                 880 


Val Ser Asp Gln Lys Glu Val Leu Pro Ala Gly Val Thr Ile Lys Gln 
                885                 890                 895     


Glu Gln Asn Leu Asp Gln Thr Tyr Leu Asp Asp Val Asn Glu Ile Ile 
            900                 905                 910         


Arg Lys Glu Phe Ser Gly Pro Pro Ala Arg Asn Gln Thr 
        915                 920                 925 


<210>  5
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asn Ala Pro Glu Arg Gln Pro Gln Pro Asp Gly Gly Asp Ala Pro 
1               5                   10                  15      


Gly His Glu Pro Gly Gly Ser Pro Gln Asp Glu Leu Asp Phe Ser Ile 
            20                  25                  30          


Leu Phe Asp Tyr Glu Tyr Leu Asn Pro Asn Glu Glu Glu Pro Asn Ala 
        35                  40                  45              


His Lys Val Ala Ser Pro Pro Ser Gly Pro Ala Tyr Pro Asp Asp Val 
    50                  55                  60                  


Leu Asp Tyr Gly Leu Lys Pro Tyr Ser Pro Leu Ala Ser Leu Ser Gly 
65                  70                  75                  80  


Glu Pro Pro Gly Arg Phe Gly Glu Pro Asp Arg Val Gly Pro Gln Lys 
                85                  90                  95      


Phe Leu Ser Ala Ala Lys Pro Ala Gly Ala Ser Gly Leu Ser Pro Arg 
            100                 105                 110         


Ile Glu Ile Thr Pro Ser His Glu Leu Ile Gln Ala Val Gly Pro Leu 
        115                 120                 125             


Arg Met Arg Asp Ala Gly Leu Leu Val Glu Gln Pro Pro Leu Ala Gly 
    130                 135                 140                 


Val Ala Ala Ser Pro Arg Phe Thr Leu Pro Val Pro Gly Phe Glu Gly 
145                 150                 155                 160 


Tyr Arg Glu Pro Leu Cys Leu Ser Pro Ala Ser Ser Gly Ser Ser Ala 
                165                 170                 175     


Ser Phe Ile Ser Asp Thr Phe Ser Pro Tyr Thr Ser Pro Cys Val Ser 
            180                 185                 190         


Pro Asn Asn Gly Gly Pro Asp Asp Leu Cys Pro Gln Phe Gln Asn Ile 
        195                 200                 205             


Pro Ala His Tyr Ser Pro Arg Thr Ser Pro Ile Met Ser Pro Arg Thr 
    210                 215                 220                 


Ser Leu Ala Glu Asp Ser Cys Leu Gly Arg His Ser Pro Val Pro Arg 
225                 230                 235                 240 


Pro Ala Ser Arg Ser Ser Ser Pro Gly Ala Lys Arg Arg His Ser Cys 
                245                 250                 255     


Ala Glu Ala Leu Val Ala Leu Pro Pro Gly Ala Ser Pro Gln Arg Ser 
            260                 265                 270         


Arg Ser Pro Ser Pro Gln Pro Ser Ser His Val Ala Pro Gln Asp His 
        275                 280                 285             


Gly Ser Pro Ala Gly Tyr Pro Pro Val Ala Gly Ser Ala Val Ile Met 
    290                 295                 300                 


Asp Ala Leu Asn Ser Leu Ala Thr Asp Ser Pro Cys Gly Ile Pro Pro 
305                 310                 315                 320 


Lys Met Trp Lys Thr Ser Pro Asp Pro Ser Pro Val Ser Ala Ala Pro 
                325                 330                 335     


Ser Lys Ala Gly Leu Pro Arg His Ile Tyr Pro Ala Val Glu Phe Leu 
            340                 345                 350         


Gly Pro Cys Glu Gln Gly Glu Arg Arg Asn Ser Ala Pro Glu Ser Ile 
        355                 360                 365             


Leu Leu Val Pro Pro Thr Trp Pro Lys Pro Leu Val Pro Ala Ile Pro 
    370                 375                 380                 


Ile Cys Ser Ile Pro Val Thr Ala Ser Leu Pro Pro Leu Glu Trp Pro 
385                 390                 395                 400 


Leu Ser Ser Gln Ser Gly Ser Tyr Glu Leu Arg Ile Glu Val Gln Pro 
                405                 410                 415     


Lys Pro His His Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala 
            420                 425                 430         


Val Lys Ala Pro Thr Gly Gly His Pro Val Val Gln Leu His Gly Tyr 
        435                 440                 445             


Met Glu Asn Lys Pro Leu Gly Leu Gln Ile Phe Ile Gly Thr Ala Asp 
    450                 455                 460                 


Glu Arg Ile Leu Lys Pro His Ala Phe Tyr Gln Val His Arg Ile Thr 
465                 470                 475                 480 


Gly Lys Thr Val Thr Thr Thr Ser Tyr Glu Lys Ile Val Gly Asn Thr 
                485                 490                 495     


Lys Val Leu Glu Ile Pro Leu Glu Pro Lys Asn Asn Met Arg Ala Thr 
            500                 505                 510         


Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn Ala Asp Ile Glu Leu 
        515                 520                 525             


Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu 
    530                 535                 540                 


Val Phe Arg Val His Ile Pro Glu Ser Ser Gly Arg Ile Val Ser Leu 
545                 550                 555                 560 


Gln Thr Ala Ser Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala His Glu 
                565                 570                 575     


Leu Pro Met Val Glu Arg Gln Asp Thr Asp Ser Cys Leu Val Tyr Gly 
            580                 585                 590         


Gly Gln Gln Met Ile Leu Thr Gly Gln Asn Phe Thr Ser Glu Ser Lys 
        595                 600                 605             


Val Val Phe Thr Glu Lys Thr Thr Asp Gly Gln Gln Ile Trp Glu Met 
    610                 615                 620                 


Glu Ala Thr Val Asp Lys Asp Lys Ser Gln Pro Asn Met Leu Phe Val 
625                 630                 635                 640 


Glu Ile Pro Glu Tyr Arg Asn Lys His Ile Arg Thr Pro Val Lys Val 
                645                 650                 655     


Asn Phe Tyr Val Ile Asn Gly Lys Arg Lys Arg Ser Gln Pro Gln His 
            660                 665                 670         


Phe Thr Tyr His Pro Val Pro Ala Ile Lys Thr Glu Pro Thr Asp Glu 
        675                 680                 685             


Tyr Asp Pro Thr Leu Ile Cys Ser Pro Thr His Gly Gly Leu Gly Ser 
    690                 695                 700                 


Gln Pro Tyr Tyr Pro Gln His Pro Met Val Ala Glu Ser Pro Ser Cys 
705                 710                 715                 720 


Leu Val Ala Thr Met Ala Pro Cys Gln Gln Phe Arg Thr Gly Leu Ser 
                725                 730                 735     


Ser Pro Asp Ala Arg Tyr Gln Gln Gln Asn Pro Ala Ala Val Leu Tyr 
            740                 745                 750         


Gln Arg Ser Lys Ser Leu Ser Pro Ser Leu Leu Gly Tyr Gln Gln Pro 
        755                 760                 765             


Ala Leu Met Ala Ala Pro Leu Ser Leu Ala Asp Ala His Arg Ser Val 
    770                 775                 780                 


Leu Val His Ala Gly Ser Gln Gly Gln Ser Ser Ala Leu Leu His Pro 
785                 790                 795                 800 


Ser Pro Thr Asn Gln Gln Ala Ser Pro Val Ile His Tyr Ser Pro Thr 
                805                 810                 815     


Asn Gln Gln Leu Arg Cys Gly Ser His Gln Glu Phe Gln His Ile Met 
            820                 825                 830         


Tyr Cys Glu Asn Phe Ala Pro Gly Thr Thr Arg Pro Gly Pro Pro Pro 
        835                 840                 845             


Val Ser Gln Gly Gln Arg Leu Ser Pro Gly Ser Tyr Pro Thr Val Ile 
    850                 855                 860                 


Gln Gln Gln Asn Ala Thr Ser Gln Arg Ala Ala Lys Asn Gly Pro Pro 
865                 870                 875                 880 


Val Ser Asp Gln Lys Glu Val Leu Pro Ala Gly Val Thr Ile Lys Gln 
                885                 890                 895     


Glu Gln Asn Leu Asp Gln Thr Tyr Leu Asp Asp Glu Leu Ile Asp Thr 
            900                 905                 910         


His Leu Ser Trp Ile Gln Asn Ile Leu 
        915                 920     


<210>  6
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gln Arg Glu Ala Ala Phe Arg Leu Gly His Cys His Pro Leu Arg 
1               5                   10                  15      


Ile Met Gly Ser Val Asp Gln Glu Glu Pro Asn Ala His Lys Val Ala 
            20                  25                  30          


Ser Pro Pro Ser Gly Pro Ala Tyr Pro Asp Asp Val Leu Asp Tyr Gly 
        35                  40                  45              


Leu Lys Pro Tyr Ser Pro Leu Ala Ser Leu Ser Gly Glu Pro Pro Gly 
    50                  55                  60                  


Arg Phe Gly Glu Pro Asp Arg Val Gly Pro Gln Lys Phe Leu Ser Ala 
65                  70                  75                  80  


Ala Lys Pro Ala Gly Ala Ser Gly Leu Ser Pro Arg Ile Glu Ile Thr 
                85                  90                  95      


Pro Ser His Glu Leu Ile Gln Ala Val Gly Pro Leu Arg Met Arg Asp 
            100                 105                 110         


Ala Gly Leu Leu Val Glu Gln Pro Pro Leu Ala Gly Val Ala Ala Ser 
        115                 120                 125             


Pro Arg Phe Thr Leu Pro Val Pro Gly Phe Glu Gly Tyr Arg Glu Pro 
    130                 135                 140                 


Leu Cys Leu Ser Pro Ala Ser Ser Gly Ser Ser Ala Ser Phe Ile Ser 
145                 150                 155                 160 


Asp Thr Phe Ser Pro Tyr Thr Ser Pro Cys Val Ser Pro Asn Asn Gly 
                165                 170                 175     


Gly Pro Asp Asp Leu Cys Pro Gln Phe Gln Asn Ile Pro Ala His Tyr 
            180                 185                 190         


Ser Pro Arg Thr Ser Pro Ile Met Ser Pro Arg Thr Ser Leu Ala Glu 
        195                 200                 205             


Asp Ser Cys Leu Gly Arg His Ser Pro Val Pro Arg Pro Ala Ser Arg 
    210                 215                 220                 


Ser Ser Ser Pro Gly Ala Lys Arg Arg His Ser Cys Ala Glu Ala Leu 
225                 230                 235                 240 


Val Ala Leu Pro Pro Gly Ala Ser Pro Gln Arg Ser Arg Ser Pro Ser 
                245                 250                 255     


Pro Gln Pro Ser Ser His Val Ala Pro Gln Asp His Gly Ser Pro Ala 
            260                 265                 270         


Gly Tyr Pro Pro Val Ala Gly Ser Ala Val Ile Met Asp Ala Leu Asn 
        275                 280                 285             


Ser Leu Ala Thr Asp Ser Pro Cys Gly Ile Pro Pro Lys Met Trp Lys 
    290                 295                 300                 


Thr Ser Pro Asp Pro Ser Pro Val Ser Ala Ala Pro Ser Lys Ala Gly 
305                 310                 315                 320 


Leu Pro Arg His Ile Tyr Pro Ala Val Glu Phe Leu Gly Pro Cys Glu 
                325                 330                 335     


Gln Gly Glu Arg Arg Asn Ser Ala Pro Glu Ser Ile Leu Leu Val Pro 
            340                 345                 350         


Pro Thr Trp Pro Lys Pro Leu Val Pro Ala Ile Pro Ile Cys Ser Ile 
        355                 360                 365             


Pro Val Thr Ala Ser Leu Pro Pro Leu Glu Trp Pro Leu Ser Ser Gln 
    370                 375                 380                 


Ser Gly Ser Tyr Glu Leu Arg Ile Glu Val Gln Pro Lys Pro His His 
385                 390                 395                 400 


Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Pro 
                405                 410                 415     


Thr Gly Gly His Pro Val Val Gln Leu His Gly Tyr Met Glu Asn Lys 
            420                 425                 430         


Pro Leu Gly Leu Gln Ile Phe Ile Gly Thr Ala Asp Glu Arg Ile Leu 
        435                 440                 445             


Lys Pro His Ala Phe Tyr Gln Val His Arg Ile Thr Gly Lys Thr Val 
    450                 455                 460                 


Thr Thr Thr Ser Tyr Glu Lys Ile Val Gly Asn Thr Lys Val Leu Glu 
465                 470                 475                 480 


Ile Pro Leu Glu Pro Lys Asn Asn Met Arg Ala Thr Ile Asp Cys Ala 
                485                 490                 495     


Gly Ile Leu Lys Leu Arg Asn Ala Asp Ile Glu Leu Arg Lys Gly Glu 
            500                 505                 510         


Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val 
        515                 520                 525             


His Ile Pro Glu Ser Ser Gly Arg Ile Val Ser Leu Gln Thr Ala Ser 
    530                 535                 540                 


Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala His Glu Leu Pro Met Val 
545                 550                 555                 560 


Glu Arg Gln Asp Thr Asp Ser Cys Leu Val Tyr Gly Gly Gln Gln Met 
                565                 570                 575     


Ile Leu Thr Gly Gln Asn Phe Thr Ser Glu Ser Lys Val Val Phe Thr 
            580                 585                 590         


Glu Lys Thr Thr Asp Gly Gln Gln Ile Trp Glu Met Glu Ala Thr Val 
        595                 600                 605             


Asp Lys Asp Lys Ser Gln Pro Asn Met Leu Phe Val Glu Ile Pro Glu 
    610                 615                 620                 


Tyr Arg Asn Lys His Ile Arg Thr Pro Val Lys Val Asn Phe Tyr Val 
625                 630                 635                 640 


Ile Asn Gly Lys Arg Lys Arg Ser Gln Pro Gln His Phe Thr Tyr His 
                645                 650                 655     


Pro Val Pro Ala Ile Lys Thr Glu Pro Thr Asp Glu Tyr Asp Pro Thr 
            660                 665                 670         


Leu Ile Cys Ser Pro Thr His Gly Gly Leu Gly Ser Gln Pro Tyr Tyr 
        675                 680                 685             


Pro Gln His Pro Met Val Ala Glu Ser Pro Ser Cys Leu Val Ala Thr 
    690                 695                 700                 


Met Ala Pro Cys Gln Gln Phe Arg Thr Gly Leu Ser Ser Pro Asp Ala 
705                 710                 715                 720 


Arg Tyr Gln Gln Gln Asn Pro Ala Ala Val Leu Tyr Gln Arg Ser Lys 
                725                 730                 735     


Ser Leu Ser Pro Ser Leu Leu Gly Tyr Gln Gln Pro Ala Leu Met Ala 
            740                 745                 750         


Ala Pro Leu Ser Leu Ala Asp Ala His Arg Ser Val Leu Val His Ala 
        755                 760                 765             


Gly Ser Gln Gly Gln Ser Ser Ala Leu Leu His Pro Ser Pro Thr Asn 
    770                 775                 780                 


Gln Gln Ala Ser Pro Val Ile His Tyr Ser Pro Thr Asn Gln Gln Leu 
785                 790                 795                 800 


Arg Cys Gly Ser His Gln Glu Phe Gln His Ile Met Tyr Cys Glu Asn 
                805                 810                 815     


Phe Ala Pro Gly Thr Thr Arg Pro Gly Pro Pro Pro Val Ser Gln Gly 
            820                 825                 830         


Gln Arg Leu Ser Pro Gly Ser Tyr Pro Thr Val Ile Gln Gln Gln Asn 
        835                 840                 845             


Ala Thr Ser Gln Arg Ala Ala Lys Asn Gly Pro Pro Val Ser Asp Gln 
    850                 855                 860                 


Lys Glu Val Leu Pro Ala Gly Val Thr Ile Lys Gln Glu Gln Asn Leu 
865                 870                 875                 880 


Asp Gln Thr Tyr Leu Asp Asp Glu Leu Ile Asp Thr His Leu Ser Trp 
                885                 890                 895     


Ile Gln Asn Ile Leu 
            900     


<210>  7
<211>  905
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gln Arg Glu Ala Ala Phe Arg Leu Gly His Cys His Pro Leu Arg 
1               5                   10                  15      


Ile Met Gly Ser Val Asp Gln Glu Glu Pro Asn Ala His Lys Val Ala 
            20                  25                  30          


Ser Pro Pro Ser Gly Pro Ala Tyr Pro Asp Asp Val Leu Asp Tyr Gly 
        35                  40                  45              


Leu Lys Pro Tyr Ser Pro Leu Ala Ser Leu Ser Gly Glu Pro Pro Gly 
    50                  55                  60                  


Arg Phe Gly Glu Pro Asp Arg Val Gly Pro Gln Lys Phe Leu Ser Ala 
65                  70                  75                  80  


Ala Lys Pro Ala Gly Ala Ser Gly Leu Ser Pro Arg Ile Glu Ile Thr 
                85                  90                  95      


Pro Ser His Glu Leu Ile Gln Ala Val Gly Pro Leu Arg Met Arg Asp 
            100                 105                 110         


Ala Gly Leu Leu Val Glu Gln Pro Pro Leu Ala Gly Val Ala Ala Ser 
        115                 120                 125             


Pro Arg Phe Thr Leu Pro Val Pro Gly Phe Glu Gly Tyr Arg Glu Pro 
    130                 135                 140                 


Leu Cys Leu Ser Pro Ala Ser Ser Gly Ser Ser Ala Ser Phe Ile Ser 
145                 150                 155                 160 


Asp Thr Phe Ser Pro Tyr Thr Ser Pro Cys Val Ser Pro Asn Asn Gly 
                165                 170                 175     


Gly Pro Asp Asp Leu Cys Pro Gln Phe Gln Asn Ile Pro Ala His Tyr 
            180                 185                 190         


Ser Pro Arg Thr Ser Pro Ile Met Ser Pro Arg Thr Ser Leu Ala Glu 
        195                 200                 205             


Asp Ser Cys Leu Gly Arg His Ser Pro Val Pro Arg Pro Ala Ser Arg 
    210                 215                 220                 


Ser Ser Ser Pro Gly Ala Lys Arg Arg His Ser Cys Ala Glu Ala Leu 
225                 230                 235                 240 


Val Ala Leu Pro Pro Gly Ala Ser Pro Gln Arg Ser Arg Ser Pro Ser 
                245                 250                 255     


Pro Gln Pro Ser Ser His Val Ala Pro Gln Asp His Gly Ser Pro Ala 
            260                 265                 270         


Gly Tyr Pro Pro Val Ala Gly Ser Ala Val Ile Met Asp Ala Leu Asn 
        275                 280                 285             


Ser Leu Ala Thr Asp Ser Pro Cys Gly Ile Pro Pro Lys Met Trp Lys 
    290                 295                 300                 


Thr Ser Pro Asp Pro Ser Pro Val Ser Ala Ala Pro Ser Lys Ala Gly 
305                 310                 315                 320 


Leu Pro Arg His Ile Tyr Pro Ala Val Glu Phe Leu Gly Pro Cys Glu 
                325                 330                 335     


Gln Gly Glu Arg Arg Asn Ser Ala Pro Glu Ser Ile Leu Leu Val Pro 
            340                 345                 350         


Pro Thr Trp Pro Lys Pro Leu Val Pro Ala Ile Pro Ile Cys Ser Ile 
        355                 360                 365             


Pro Val Thr Ala Ser Leu Pro Pro Leu Glu Trp Pro Leu Ser Ser Gln 
    370                 375                 380                 


Ser Gly Ser Tyr Glu Leu Arg Ile Glu Val Gln Pro Lys Pro His His 
385                 390                 395                 400 


Arg Ala His Tyr Glu Thr Glu Gly Ser Arg Gly Ala Val Lys Ala Pro 
                405                 410                 415     


Thr Gly Gly His Pro Val Val Gln Leu His Gly Tyr Met Glu Asn Lys 
            420                 425                 430         


Pro Leu Gly Leu Gln Ile Phe Ile Gly Thr Ala Asp Glu Arg Ile Leu 
        435                 440                 445             


Lys Pro His Ala Phe Tyr Gln Val His Arg Ile Thr Gly Lys Thr Val 
    450                 455                 460                 


Thr Thr Thr Ser Tyr Glu Lys Ile Val Gly Asn Thr Lys Val Leu Glu 
465                 470                 475                 480 


Ile Pro Leu Glu Pro Lys Asn Asn Met Arg Ala Thr Ile Asp Cys Ala 
                485                 490                 495     


Gly Ile Leu Lys Leu Arg Asn Ala Asp Ile Glu Leu Arg Lys Gly Glu 
            500                 505                 510         


Thr Asp Ile Gly Arg Lys Asn Thr Arg Val Arg Leu Val Phe Arg Val 
        515                 520                 525             


His Ile Pro Glu Ser Ser Gly Arg Ile Val Ser Leu Gln Thr Ala Ser 
    530                 535                 540                 


Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala His Glu Leu Pro Met Val 
545                 550                 555                 560 


Glu Arg Gln Asp Thr Asp Ser Cys Leu Val Tyr Gly Gly Gln Gln Met 
                565                 570                 575     


Ile Leu Thr Gly Gln Asn Phe Thr Ser Glu Ser Lys Val Val Phe Thr 
            580                 585                 590         


Glu Lys Thr Thr Asp Gly Gln Gln Ile Trp Glu Met Glu Ala Thr Val 
        595                 600                 605             


Asp Lys Asp Lys Ser Gln Pro Asn Met Leu Phe Val Glu Ile Pro Glu 
    610                 615                 620                 


Tyr Arg Asn Lys His Ile Arg Thr Pro Val Lys Val Asn Phe Tyr Val 
625                 630                 635                 640 


Ile Asn Gly Lys Arg Lys Arg Ser Gln Pro Gln His Phe Thr Tyr His 
                645                 650                 655     


Pro Val Pro Ala Ile Lys Thr Glu Pro Thr Asp Glu Tyr Asp Pro Thr 
            660                 665                 670         


Leu Ile Cys Ser Pro Thr His Gly Gly Leu Gly Ser Gln Pro Tyr Tyr 
        675                 680                 685             


Pro Gln His Pro Met Val Ala Glu Ser Pro Ser Cys Leu Val Ala Thr 
    690                 695                 700                 


Met Ala Pro Cys Gln Gln Phe Arg Thr Gly Leu Ser Ser Pro Asp Ala 
705                 710                 715                 720 


Arg Tyr Gln Gln Gln Asn Pro Ala Ala Val Leu Tyr Gln Arg Ser Lys 
                725                 730                 735     


Ser Leu Ser Pro Ser Leu Leu Gly Tyr Gln Gln Pro Ala Leu Met Ala 
            740                 745                 750         


Ala Pro Leu Ser Leu Ala Asp Ala His Arg Ser Val Leu Val His Ala 
        755                 760                 765             


Gly Ser Gln Gly Gln Ser Ser Ala Leu Leu His Pro Ser Pro Thr Asn 
    770                 775                 780                 


Gln Gln Ala Ser Pro Val Ile His Tyr Ser Pro Thr Asn Gln Gln Leu 
785                 790                 795                 800 


Arg Cys Gly Ser His Gln Glu Phe Gln His Ile Met Tyr Cys Glu Asn 
                805                 810                 815     


Phe Ala Pro Gly Thr Thr Arg Pro Gly Pro Pro Pro Val Ser Gln Gly 
            820                 825                 830         


Gln Arg Leu Ser Pro Gly Ser Tyr Pro Thr Val Ile Gln Gln Gln Asn 
        835                 840                 845             


Ala Thr Ser Gln Arg Ala Ala Lys Asn Gly Pro Pro Val Ser Asp Gln 
    850                 855                 860                 


Lys Glu Val Leu Pro Ala Gly Val Thr Ile Lys Gln Glu Gln Asn Leu 
865                 870                 875                 880 


Asp Gln Thr Tyr Leu Asp Asp Val Asn Glu Ile Ile Arg Lys Glu Phe 
                885                 890                 895     


Ser Gly Pro Pro Ala Arg Asn Gln Thr 
            900                 905 


<210>  8
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Pro Arg Thr Ser Leu Ala Glu Asp Ser Cys Leu Gly Arg His 
1               5                   10                  15      


Ser Pro Val Pro Arg Pro Ala Ser Arg Ser Ser Ser Pro Gly Ala Lys 
            20                  25                  30          


Arg Arg His Ser Cys Ala Glu Ala Leu Val Ala Leu Pro Pro Gly Ala 
        35                  40                  45              


Ser Pro Gln Arg Ser Arg Ser Pro Ser Pro Gln Pro Ser Ser His Val 
    50                  55                  60                  


Ala Pro Gln Asp His Gly Ser Pro Ala Gly Tyr Pro Pro Val Ala Gly 
65                  70                  75                  80  


Ser Ala Val Ile Met Asp Ala Leu Asn Ser Leu Ala Thr Asp Ser Pro 
                85                  90                  95      


Cys Gly Ile Pro Pro Lys Met Trp Lys Thr Ser Pro Asp Pro Ser Pro 
            100                 105                 110         


Val Ser Ala Ala Pro Ser Lys Ala Gly Leu Pro Arg His Ile Tyr Pro 
        115                 120                 125             


Ala Val Glu Phe Leu Gly Pro Cys Glu Gln Gly Glu Arg Arg Asn Ser 
    130                 135                 140                 


Ala Pro Glu Ser Ile Leu Leu Val Pro Pro Thr Trp Pro Lys Pro Leu 
145                 150                 155                 160 


Val Pro Ala Ile Pro Ile Cys Ser Ile Pro Val Thr Ala Ser Leu Pro 
                165                 170                 175     


Pro Leu Glu Trp Pro Leu Ser Ser Gln Ser Gly Ser Tyr Glu Leu Arg 
            180                 185                 190         


Ile Glu Val Gln Pro Lys Pro His His Arg Ala His Tyr Glu Thr Glu 
        195                 200                 205             


Gly Ser Arg Gly Ala Val Lys Ala Pro Thr Gly Gly His Pro Val Val 
    210                 215                 220                 


Gln Leu His Gly Tyr Met Glu Asn Lys Pro Leu Gly Leu Gln Ile Phe 
225                 230                 235                 240 


Ile Gly Thr Ala Asp Glu Arg Ile Leu Lys Pro His Ala Phe Tyr Gln 
                245                 250                 255     


Val His Arg Ile Thr Gly Lys Thr Val Thr Thr Thr Ser Tyr Glu Lys 
            260                 265                 270         


Ile Val Gly Asn Thr Lys Val Leu Glu Ile Pro Leu Glu Pro Lys Asn 
        275                 280                 285             


Asn Met Arg Ala Thr Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn 
    290                 295                 300                 


Ala Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn 
305                 310                 315                 320 


Thr Arg Val Arg Leu Val Phe Arg Val His Ile Pro Glu Ser Ser Gly 
                325                 330                 335     


Arg Ile Val Ser Leu Gln Thr Ala Ser Asn Pro Ile Glu Cys Ser Gln 
            340                 345                 350         


Arg Ser Ala His Glu Leu Pro Met Val Glu Arg Gln Asp Thr Asp Ser 
        355                 360                 365             


Cys Leu Val Tyr Gly Gly Gln Gln Met Ile Leu Thr Gly Gln Asn Phe 
    370                 375                 380                 


Thr Ser Glu Ser Lys Val Val Phe Thr Glu Lys Thr Thr Asp Gly Gln 
385                 390                 395                 400 


Gln Ile Trp Glu Met Glu Ala Thr Val Asp Lys Asp Lys Ser Gln Pro 
                405                 410                 415     


Asn Met Leu Phe Val Glu Ile Pro Glu Tyr Arg Asn Lys His Ile Arg 
            420                 425                 430         


Thr Pro Val Lys Val Asn Phe Tyr Val Ile Asn Gly Lys Arg Lys Arg 
        435                 440                 445             


Ser Gln Pro Gln His Phe Thr Tyr His Pro Val Pro Ala Ile Lys Thr 
    450                 455                 460                 


Glu Pro Thr Asp Glu Tyr Asp Pro Thr Leu Ile Cys Ser Pro Thr His 
465                 470                 475                 480 


Gly Gly Leu Gly Ser Gln Pro Tyr Tyr Pro Gln His Pro Met Val Ala 
                485                 490                 495     


Glu Ser Pro Ser Cys Leu Val Ala Thr Met Ala Pro Cys Gln Gln Phe 
            500                 505                 510         


Arg Thr Gly Leu Ser Ser Pro Asp Ala Arg Tyr Gln Gln Gln Asn Pro 
        515                 520                 525             


Ala Ala Val Leu Tyr Gln Arg Ser Lys Ser Leu Ser Pro Ser Leu Leu 
    530                 535                 540                 


Gly Tyr Gln Gln Pro Ala Leu Met Ala Ala Pro Leu Ser Leu Ala Asp 
545                 550                 555                 560 


Ala His Arg Ser Val Leu Val His Ala Gly Ser Gln Gly Gln Ser Ser 
                565                 570                 575     


Ala Leu Leu His Pro Ser Pro Thr Asn Gln Gln Ala Ser Pro Val Ile 
            580                 585                 590         


His Tyr Ser Pro Thr Asn Gln Gln Leu Arg Cys Gly Ser His Gln Glu 
        595                 600                 605             


Phe Gln His Ile Met Tyr Cys Glu Asn Phe Ala Pro Gly Thr Thr Arg 
    610                 615                 620                 


Pro Gly Pro Pro Pro Val Ser Gln Gly Gln Arg Leu Ser Pro Gly Ser 
625                 630                 635                 640 


Tyr Pro Thr Val Ile Gln Gln Gln Asn Ala Thr Ser Gln Arg Ala Ala 
                645                 650                 655     


Lys Asn Gly Pro Pro Val Ser Asp Gln Lys Glu Val Leu Pro Ala Gly 
            660                 665                 670         


Val Thr Ile Lys Gln Glu Gln Asn Leu Asp Gln Thr Tyr Leu Asp Asp 
        675                 680                 685             


Glu Leu Ile Asp Thr His Leu Ser Trp Ile Gln Asn Ile Leu 
    690                 695                 700         


<210>  9
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Pro Leu Pro Val Cys Leu Pro Ile Met Leu Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ser Leu Leu Leu Leu Leu Leu Leu Pro Gly Pro Gly Ser Gly Glu 
            20                  25                  30          


Ala Ser Arg Ile Leu Arg Val His Arg Arg Gly Ile Leu Glu Leu Ala 
        35                  40                  45              


Gly Thr Val Gly Cys Val Gly Pro Arg Thr Pro Ile Ala Tyr Met Lys 
    50                  55                  60                  


Tyr Gly Cys Phe Cys Gly Leu Gly Gly His Gly Gln Pro Arg Asp Ala 
65                  70                  75                  80  


Ile Asp Trp Cys Cys His Gly His Asp Cys Cys Tyr Thr Arg Ala Glu 
                85                  90                  95      


Glu Ala Gly Cys Ser Pro Lys Thr Glu Arg Tyr Ser Trp Gln Cys Val 
            100                 105                 110         


Asn Gln Ser Val Leu Cys Gly Pro Ala Glu Asn Lys Cys Gln Glu Leu 
        115                 120                 125             


Leu Cys Lys Cys Asp Gln Glu Ile Ala Asn Cys Leu Ala Gln Thr Glu 
    130                 135                 140                 


Tyr Asn Leu Lys Tyr Leu Phe Tyr Pro Gln Phe Leu Cys Glu Pro Asp 
145                 150                 155                 160 


Ser Pro Lys Cys Asp 
                165 


<210>  10
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg Leu Ala Val Pro Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Thr Gly Pro Trp Trp Ala Ala Gly Gly Arg 
        35                  40                  45              


Gly Pro Arg Glu Val Ser Pro Gly Ala Gly Thr Glu Val Gln Asp Ala 
    50                  55                  60                  


Leu Glu Arg Ala Leu Pro Glu Leu Gln Gln Ala Leu Ser Ala Leu Lys 
65                  70                  75                  80  


Gln Ala Gly Gly Ala Arg Ala Val Gly Ala Gly Leu Ala Glu Val Phe 
                85                  90                  95      


Gln Leu Val Glu Glu Ala Trp Leu Leu Pro Ala Val Gly Arg Glu Val 
            100                 105                 110         


Ala Gln Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu 
        115                 120                 125             


Leu Leu Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala 
    130                 135                 140                 


Ala Arg Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val 
145                 150                 155                 160 


Ala Arg Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu 
                165                 170                 175     


Pro Val Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe 
            180                 185                 190         


Lys His Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu 
        195                 200                 205             


Asp Ala Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg 
    210                 215                 220                 


His Cys Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala 
225                 230                 235                 240 


Val Gln Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro 
                245                 250                 255     


Leu Ala Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu 
            260                 265                 270         


Ala Val Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu 
        275                 280                 285             


Arg Ser Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp 
    290                 295                 300                 


Pro Gly Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln 
305                 310                 315                 320 


Gly Arg Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser 
                325                 330                 335     


Asn Arg Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu 
            340                 345                 350         


Ala Ala Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile 
        355                 360                 365             


Gly Ala Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly 
    370                 375                 380                 


Thr Lys Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu 
385                 390                 395                 400 


Val Pro Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu 
                405                 410                 415     


Val Gln Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser 
            420                 425                 430         


Phe Arg Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu 
        435                 440                 445             


Glu Glu Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys 
    450                 455                 460                 


Arg Phe Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser 
465                 470                 475                 480 


Thr Cys Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Arg Phe Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg 
            500                 505                 510         


Ser Leu Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly 
        515                 520                 525             


Ile His Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu 
    530                 535                 540                 


Met Leu His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp 
545                 550                 555                 560 


Thr Pro Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu 
                565                 570                 575     


Ala Ser Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe 
            580                 585                 590         


Ile Asp Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile 
        595                 600                 605             


Gln Ser Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly 
    610                 615                 620                 


Ala Leu Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His 
625                 630                 635                 640 


Lys Glu Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile 
                645                 650                 655     


Ile Asp Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met 
            660                 665                 670         


Gln Ala Val Leu Thr Phe Asn Gly Ile Lys Trp Ser His Glu Tyr Gln 
        675                 680                 685             


Glu Ala Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser 
    690                 695                 700                 


Arg Asp Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro 
705                 710                 715                 720 


Met Gly Pro Thr 
                


<210>  11
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Ala Val Ala Arg Ala His Gly Gly Leu Arg Val Ala Arg Ala 
1               5                   10                  15      


Arg Glu Ser Val Ala Gly Gly Arg His Arg Gly Ala Gly Arg Pro Gly 
            20                  25                  30          


Ala Arg Ala Ala Gly Ala Ala Ala Gly Leu Val Arg Ala Glu Ala Gly 
        35                  40                  45              


Gly Arg Arg Ala Gly Arg Gly Arg Arg Pro Gly Arg Gly Leu Pro Thr 
    50                  55                  60                  


Gly Gly Gly Gly Leu Ala Ala Ala Ala Val Gly Arg Glu Val Ala Gln 
65                  70                  75                  80  


Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu Leu Leu 
                85                  90                  95      


Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala Ala Arg 
            100                 105                 110         


Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val Ala Arg 
        115                 120                 125             


Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu Pro Val 
    130                 135                 140                 


Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe Lys His 
145                 150                 155                 160 


Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu Asp Ala 
                165                 170                 175     


Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg His Cys 
            180                 185                 190         


Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala Val Gln 
        195                 200                 205             


Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro Leu Ala 
    210                 215                 220                 


Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu Ala Val 
225                 230                 235                 240 


Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu Arg Ser 
                245                 250                 255     


Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp Pro Gly 
            260                 265                 270         


Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln Gly Arg 
        275                 280                 285             


Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser Asn Arg 
    290                 295                 300                 


Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu Ala Ala 
305                 310                 315                 320 


Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile Gly Ala 
                325                 330                 335     


Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly Thr Lys 
            340                 345                 350         


Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu Val Pro 
        355                 360                 365             


Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu Val Gln 
    370                 375                 380                 


Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser Phe Arg 
385                 390                 395                 400 


Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu Glu Glu 
                405                 410                 415     


Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys Arg Phe 
            420                 425                 430         


Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser Thr Cys 
        435                 440                 445             


Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro Arg Phe 
    450                 455                 460                 


Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg Ser Leu 
465                 470                 475                 480 


Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly Ile His 
                485                 490                 495     


Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu Met Leu 
            500                 505                 510         


His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp Thr Pro 
        515                 520                 525             


Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu Ala Ser 
    530                 535                 540                 


Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe Ile Asp 
545                 550                 555                 560 


Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile Gln Ser 
                565                 570                 575     


Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly Ala Leu 
            580                 585                 590         


Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His Lys Glu 
        595                 600                 605             


Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile Ile Asp 
    610                 615                 620                 


Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met Gln Ala 
625                 630                 635                 640 


Val Leu Thr Phe Asn Gly Ile Lys Trp Ser His Glu Tyr Gln Glu Ala 
                645                 650                 655     


Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser Arg Asp 
            660                 665                 670         


Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro Met Gly 
        675                 680                 685             


Pro Thr 
    690 


<210>  12
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Ser Ala Ser Ser Gly Pro Ser Ser Ser Val Gly Phe Ser Ser 
1               5                   10                  15      


Phe Asp Pro Ala Val Pro Ser Cys Thr Leu Ser Ser Ala Ala Ser Gly 
            20                  25                  30          


Ile Lys Arg Pro Met Ala Ser Glu Val Leu Glu Ala Arg Gln Asp Ser 
        35                  40                  45              


Tyr Ile Ser Leu Val Pro Tyr Ala Ser Gly Met Pro Ile Lys Lys Ile 
    50                  55                  60                  


Gly His Arg Ser Val Asp Ser Ser Gly Glu Thr Thr Tyr Lys Lys Thr 
65                  70                  75                  80  


Thr Ser Ser Ala Leu Lys Gly Ala Ile Gln Leu Gly Ile Thr His Thr 
                85                  90                  95      


Val Gly Ser Leu Ser Thr Lys Pro Glu Arg Asp Val Leu Met Gln Asp 
            100                 105                 110         


Phe Tyr Val Val Glu Ser Ile Phe Phe Pro Ser Glu Gly Ser Asn Leu 
        115                 120                 125             


Thr Pro Ala His His Tyr Asn Asp Phe Arg Phe Lys Thr Tyr Ala Pro 
    130                 135                 140                 


Val Ala Phe Arg Tyr Phe Arg Glu Leu Phe Gly Ile Arg Pro Asp Asp 
145                 150                 155                 160 


Tyr Leu Tyr Ser Leu Cys Ser Glu Pro Leu Ile Glu Leu Cys Ser Ser 
                165                 170                 175     


Gly Ala Ser Gly Ser Leu Phe Tyr Val Ser Ser Asp Asp Glu Phe Ile 
            180                 185                 190         


Ile Lys Thr Val Gln His Lys Glu Ala Glu Phe Leu Gln Lys Leu Leu 
        195                 200                 205             


Pro Gly Tyr Tyr Met Asn Leu Asn Gln Asn Pro Arg Thr Leu Leu Pro 
    210                 215                 220                 


Lys Phe Tyr Gly Leu Tyr Cys Val Gln Ala Gly Gly Lys Asn Ile Arg 
225                 230                 235                 240 


Ile Val Val Met Asn Asn Leu Leu Pro Arg Ser Val Lys Met His Ile 
                245                 250                 255     


Lys Tyr Asp Leu Lys Gly Ser Thr Tyr Lys Arg Arg Ala Ser Gln Lys 
            260                 265                 270         


Glu Arg Glu Lys Pro Leu Pro Thr Phe Lys Asp Leu Asp Phe Leu Gln 
        275                 280                 285             


Asp Ile Pro Asp Gly Leu Phe Leu Asp Ala Asp Met Tyr Asn Ala Leu 
    290                 295                 300                 


Cys Lys Thr Leu Gln Arg Asp Cys Leu Val Leu Gln Ser Phe Lys Ile 
305                 310                 315                 320 


Met Asp Tyr Ser Leu Leu Met Ser Ile His Asn Ile Asp His Ala Gln 
                325                 330                 335     


Arg Glu Pro Leu Ser Ser Glu Thr Gln Tyr Ser Val Asp Thr Arg Arg 
            340                 345                 350         


Pro Ala Pro Gln Lys Ala Leu Tyr Ser Thr Ala Met Glu Ser Ile Gln 
        355                 360                 365             


Gly Glu Ala Arg Arg Gly Gly Thr Met Glu Thr Asp Asp His Met Gly 
    370                 375                 380                 


Gly Ile Pro Ala Arg Asn Ser Lys Gly Glu Arg Leu Leu Leu Tyr Ile 
385                 390                 395                 400 


Gly Ile Ile Asp Ile Leu Gln Ser Tyr Arg Phe Val Lys Lys Leu Glu 
                405                 410                 415     


His Ser Trp Lys Ala Leu Val His Asp Gly Asp Thr Val Ser Val His 
            420                 425                 430         


Arg Pro Gly Phe Tyr Ala Glu Arg Phe Gln Arg Phe Met Cys Asn Thr 
        435                 440                 445             


Val Phe Lys Lys Ile Pro Leu Lys Pro Ser Pro Ser Lys Lys Phe Arg 
    450                 455                 460                 


Ser Gly Ser Ser Phe Ser Arg Arg Ala Gly Ser Ser Gly Asn Ser Cys 
465                 470                 475                 480 


Ile Thr Tyr Gln Pro Ser Val Ser Gly Glu His Lys Ala Gln Val Thr 
                485                 490                 495     


Thr Lys Ala Glu Val Glu Pro Gly Val His Leu Gly Arg Pro Asp Val 
            500                 505                 510         


Leu Pro Gln Thr Pro Pro Leu Glu Glu Ile Ser Glu Gly Ser Pro Ile 
        515                 520                 525             


Pro Asp Pro Ser Phe Ser Pro Leu Val Gly Glu Thr Leu Gln Met Leu 
    530                 535                 540                 


Thr Thr Ser Thr Thr Leu Glu Lys Leu Glu Val Ala Glu Ser Glu Phe 
545                 550                 555                 560 


Thr His 
        


<210>  13
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Ser Ala Ser Ser Gly Pro Ser Ser Ser Val Gly Phe Ser Ser 
1               5                   10                  15      


Phe Asp Pro Ala Val Pro Ser Cys Thr Leu Ser Ser Ala Ser Gly Ile 
            20                  25                  30          


Lys Arg Pro Met Ala Ser Glu Val Pro Tyr Ala Ser Gly Met Pro Ile 
        35                  40                  45              


Lys Lys Ile Gly His Arg Ser Val Asp Ser Ser Gly Glu Thr Thr Tyr 
    50                  55                  60                  


Lys Lys Thr Thr Ser Ser Ala Leu Lys Gly Ala Ile Gln Leu Gly Ile 
65                  70                  75                  80  


Thr His Thr Val Gly Ser Leu Ser Thr Lys Pro Glu Arg Asp Val Leu 
                85                  90                  95      


Met Gln Asp Phe Tyr Val Val Glu Ser Ile Phe Phe Pro Ser Glu Gly 
            100                 105                 110         


Ser Asn Leu Thr Pro Ala His His Tyr Asn Asp Phe Arg Phe Lys Thr 
        115                 120                 125             


Tyr Ala Pro Val Ala Phe Arg Tyr Phe Arg Glu Leu Phe Gly Ile Arg 
    130                 135                 140                 


Pro Asp Asp Tyr Leu Tyr Ser Leu Cys Ser Glu Pro Leu Ile Glu Leu 
145                 150                 155                 160 


Cys Ser Ser Gly Ala Ser Gly Ser Leu Phe Tyr Val Ser Ser Asp Asp 
                165                 170                 175     


Glu Phe Ile Ile Lys Thr Val Gln His Lys Glu Ala Glu Phe Leu Gln 
            180                 185                 190         


Lys Leu Leu Pro Gly Tyr Tyr Met Asn Leu Asn Gln Asn Pro Arg Thr 
        195                 200                 205             


Leu Leu Pro Lys Phe Tyr Gly Leu Tyr Cys Val Gln Ala Gly Gly Lys 
    210                 215                 220                 


Asn Ile Arg Ile Val Val Met Asn Asn Leu Leu Pro Arg Ser Val Lys 
225                 230                 235                 240 


Met His Ile Lys Tyr Asp Leu Lys Gly Ser Thr Tyr Lys Arg Arg Ala 
                245                 250                 255     


Ser Gln Lys Glu Arg Glu Lys Pro Leu Pro Thr Phe Lys Asp Leu Asp 
            260                 265                 270         


Phe Leu Gln Asp Ile Pro Asp Gly Leu Phe Leu Asp Ala Asp Met Tyr 
        275                 280                 285             


Asn Ala Leu Cys Lys Thr Leu Gln Arg Asp Cys Leu Val Leu Gln Ser 
    290                 295                 300                 


Phe Lys Ile Met Asp Tyr Ser Leu Leu Met Ser Ile His Asn Ile Asp 
305                 310                 315                 320 


His Ala Gln Arg Glu Pro Leu Ser Ser Glu Thr Gln Tyr Ser Val Asp 
                325                 330                 335     


Thr Arg Arg Pro Ala Pro Gln Lys Ala Leu Tyr Ser Thr Ala Met Glu 
            340                 345                 350         


Ser Ile Gln Gly Glu Ala Arg Arg Gly Gly Thr Met Glu Thr Asp Asp 
        355                 360                 365             


His Met Gly Gly Ile Pro Ala Arg Asn Ser Lys Gly Glu Arg Leu Leu 
    370                 375                 380                 


Leu Tyr Ile Gly Ile Ile Asp Ile Leu Gln Ser Tyr Arg Phe Val Lys 
385                 390                 395                 400 


Lys Leu Glu His Ser Trp Lys Ala Leu Val His Asp Gly Asp Thr Val 
                405                 410                 415     


Ser Val His Arg Pro Gly Phe Tyr Ala Glu Arg Phe Gln Arg Phe Met 
            420                 425                 430         


Cys Asn Thr Val Phe Lys Lys Ile Pro Cys Val His Leu Gly Arg Pro 
        435                 440                 445             


Asp Val Leu Pro Gln Thr Pro Pro Leu Glu Glu Ile Ser Glu Gly Ser 
    450                 455                 460                 


Pro Ile Pro Asp Pro Ser Phe Ser Pro Leu Val Gly Glu Thr Leu Gln 
465                 470                 475                 480 


Met Leu Thr Thr Ser Thr Thr Leu Glu Lys Leu Glu Val Ala Glu Ser 
                485                 490                 495     


Glu Phe Thr His 
            500 


<210>  14
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Ser Ala Ser Ser Gly Pro Ser Ser Ser Val Gly Phe Ser Ser 
1               5                   10                  15      


Phe Asp Pro Ala Val Pro Ser Cys Thr Leu Ser Ser Ala Ser Gly Ile 
            20                  25                  30          


Lys Arg Pro Met Ala Ser Glu Val Pro Tyr Ala Ser Gly Met Pro Ile 
        35                  40                  45              


Lys Lys Ile Gly His Arg Ser Val Asp Ser Ser Gly Glu Thr Thr Tyr 
    50                  55                  60                  


Lys Lys Thr Thr Ser Ser Ala Leu Lys Gly Ala Ile Gln Leu Gly Ile 
65                  70                  75                  80  


Thr His Thr Val Gly Ser Leu Ser Thr Lys Pro Glu Arg Asp Val Leu 
                85                  90                  95      


Met Gln Asp Phe Tyr Val Val Glu Ser Ile Phe Phe Pro Ser Glu Gly 
            100                 105                 110         


Ser Asn Leu Thr Pro Ala His His Tyr Asn Asp Phe Arg Phe Lys Thr 
        115                 120                 125             


Tyr Ala Pro Val Ala Phe Arg Tyr Phe Arg Glu Leu Phe Gly Ile Arg 
    130                 135                 140                 


Pro Asp Asp Tyr Leu Tyr Ser Leu Cys Ser Glu Pro Leu Ile Glu Leu 
145                 150                 155                 160 


Cys Ser Ser Gly Ala Ser Gly Ser Leu Phe Tyr Val Ser Ser Asp Asp 
                165                 170                 175     


Glu Phe Ile Ile Lys Thr Val Gln His Lys Glu Ala Glu Phe Leu Gln 
            180                 185                 190         


Lys Leu Leu Pro Gly Tyr Tyr Met Asn Leu Asn Gln Asn Pro Arg Thr 
        195                 200                 205             


Leu Leu Pro Lys Phe Tyr Gly Leu Tyr Cys Val Gln Ala Gly Gly Lys 
    210                 215                 220                 


Asn Ile Arg Ile Val Val Met Asn Asn Leu Leu Pro Arg Ser Val Lys 
225                 230                 235                 240 


Met His Ile Lys Tyr Asp Leu Lys Gly Ser Thr Tyr Lys Arg Arg Ala 
                245                 250                 255     


Ser Gln Lys Glu Arg Glu Lys Pro Leu Pro Thr Phe Lys Asp Leu Asp 
            260                 265                 270         


Phe Leu Gln Asp Ile Pro Asp Gly Leu Phe Leu Asp Ala Asp Met Tyr 
        275                 280                 285             


Asn Ala Leu Cys Lys Thr Leu Gln Arg Asp Cys Leu Val Leu Gln Ser 
    290                 295                 300                 


Phe Lys Ile Met Asp Tyr Ser Leu Leu Met Ser Ile His Asn Ile Asp 
305                 310                 315                 320 


His Ala Gln Arg Glu Pro Leu Ser Ser Glu Thr Gln Tyr Ser Val Asp 
                325                 330                 335     


Thr Arg Arg Pro Ala Pro Gln Lys Ala Leu Tyr Ser Thr Ala Met Glu 
            340                 345                 350         


Ser Ile Gln Gly Glu Ala Arg Arg Gly Gly Thr Met Glu Thr Asp Asp 
        355                 360                 365             


His Met Gly Gly Ile Pro Ala Arg Asn Ser Lys Gly Glu Arg Leu Leu 
    370                 375                 380                 


Leu Tyr Ile Gly Ile Ile Asp Ile Leu Gln Ser Tyr Arg Phe Val Lys 
385                 390                 395                 400 


Lys Leu Glu His Ser Trp Lys Ala Leu Val His Asp Gly Asp Thr Val 
                405                 410                 415     


Ser Val His Arg Pro Gly Phe Tyr Ala Glu Arg Phe Gln Arg Phe Met 
            420                 425                 430         


Cys Asn Thr Val Phe Lys Lys Ile Pro Leu Lys Pro Ser Pro Ser Lys 
        435                 440                 445             


Lys Phe Arg Ser Gly Ser Ser Phe Ser Arg Arg Ala Gly Ser Ser Gly 
    450                 455                 460                 


Asn Ser Cys Ile Thr Tyr Gln Pro Ser Val Ser Gly Glu His Lys Ala 
465                 470                 475                 480 


Gln Val Thr Thr Lys Ala Glu Val Glu Pro Gly Val His Leu Gly Arg 
                485                 490                 495     


Pro Asp Val Leu Pro Gln Thr Pro Pro Leu Glu Glu Ile Ser Glu Gly 
            500                 505                 510         


Ser Pro Ile Pro Asp Pro Ser Phe Ser Pro Leu Val Gly Glu Thr Leu 
        515                 520                 525             


Gln Met Leu Thr Thr Ser Thr Thr Leu Glu Lys Leu Glu Val Ala Glu 
    530                 535                 540                 


Ser Glu Phe Thr His 
545                 


<210>  15
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Ser Ala Ser Ser Gly Pro Ser Ser Ser Val Gly Phe Ser Ser 
1               5                   10                  15      


Phe Asp Pro Ala Val Pro Ser Cys Thr Leu Ser Ser Ala Ala Ser Gly 
            20                  25                  30          


Ile Lys Arg Pro Met Ala Ser Glu Val Pro Tyr Ala Ser Gly Met Pro 
        35                  40                  45              


Ile Lys Lys Ile Gly His Arg Ser Val Asp Ser Ser Gly Glu Thr Thr 
    50                  55                  60                  


Tyr Lys Lys Thr Thr Ser Ser Ala Leu Lys Gly Ala Ile Gln Leu Gly 
65                  70                  75                  80  


Ile Thr His Thr Val Gly Ser Leu Ser Thr Lys Pro Glu Arg Asp Val 
                85                  90                  95      


Leu Met Gln Asp Phe Tyr Val Val Glu Ser Ile Phe Phe Pro Ser Glu 
            100                 105                 110         


Gly Ser Asn Leu Thr Pro Ala His His Tyr Asn Asp Phe Arg Phe Lys 
        115                 120                 125             


Thr Tyr Ala Pro Val Ala Phe Arg Tyr Phe Arg Glu Leu Phe Gly Ile 
    130                 135                 140                 


Arg Pro Asp Asp Tyr Leu Tyr Ser Leu Cys Ser Glu Pro Leu Ile Glu 
145                 150                 155                 160 


Leu Cys Ser Ser Gly Ala Ser Gly Ser Leu Phe Tyr Val Ser Ser Asp 
                165                 170                 175     


Asp Glu Phe Ile Ile Lys Thr Val Gln His Lys Glu Ala Glu Phe Leu 
            180                 185                 190         


Gln Lys Leu Leu Pro Gly Tyr Tyr Met Asn Leu Asn Gln Asn Pro Arg 
        195                 200                 205             


Thr Leu Leu Pro Lys Phe Tyr Gly Leu Tyr Cys Val Gln Ala Gly Gly 
    210                 215                 220                 


Lys Asn Ile Arg Ile Val Val Met Asn Asn Leu Leu Pro Arg Ser Val 
225                 230                 235                 240 


Lys Met His Ile Lys Tyr Asp Leu Lys Gly Ser Thr Tyr Lys Arg Arg 
                245                 250                 255     


Ala Ser Gln Lys Glu Arg Glu Lys Pro Leu Pro Thr Phe Lys Asp Leu 
            260                 265                 270         


Asp Phe Leu Gln Asp Ile Pro Asp Gly Leu Phe Leu Asp Ala Asp Met 
        275                 280                 285             


Tyr Asn Ala Leu Cys Lys Thr Leu Gln Arg Asp Cys Leu Val Leu Gln 
    290                 295                 300                 


Ser Phe Lys Ile Met Asp Tyr Ser Leu Leu Met Ser Ile His Asn Ile 
305                 310                 315                 320 


Asp His Ala Gln Arg Glu Pro Leu Ser Ser Glu Thr Gln Tyr Ser Val 
                325                 330                 335     


Asp Thr Arg Arg Pro Ala Pro Gln Lys Ala Leu Tyr Ser Thr Ala Met 
            340                 345                 350         


Glu Ser Ile Gln Gly Glu Ala Arg Arg Gly Gly Thr Met Glu Thr Asp 
        355                 360                 365             


Asp Gln Phe Val Lys Lys Leu Glu His Ser Trp Lys Ala Leu Val His 
    370                 375                 380                 


Asp Gly Asp Thr Val Ser Val His Arg Pro Gly Phe Tyr Ala Glu Arg 
385                 390                 395                 400 


Phe Gln Arg Phe Met Cys Asn Thr Val Phe Lys Lys Ile Pro Leu Lys 
                405                 410                 415     


Pro Ser Pro Ser Lys Lys Phe Arg Ser Gly Ser Ser Phe Ser Arg Arg 
            420                 425                 430         


Ala Gly Ser Ser Gly Asn Ser Cys Ile Thr Tyr Gln Pro Ser Val Ser 
        435                 440                 445             


Gly Glu His Lys Ala Gln Val Thr Thr Lys Ala Glu Val Glu Pro Gly 
    450                 455                 460                 


Val His Leu Gly Arg Pro Asp Val Leu Pro Gln Thr Pro Pro Leu Glu 
465                 470                 475                 480 


Glu Ile Ser Glu Gly Ser Pro Ile Pro Asp Pro Ser Phe Ser Pro Leu 
                485                 490                 495     


Val Gly Glu Thr Leu Gln Met Leu Thr Thr Ser Thr Thr Leu Glu Lys 
            500                 505                 510         


Leu Glu Val Ala Glu Ser Glu Phe Thr His 
        515                 520         


<210>  16
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Pro Arg Lys Ala Phe Leu Leu Leu Leu Leu Leu Gly Leu Val 
1               5                   10                  15      


Gln Leu Leu Ala Val Ala Gly Ala Glu Gly Pro Asp Glu Asp Ser Ser 
            20                  25                  30          


Asn Arg Glu Asn Ala Ile Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp 
        35                  40                  45              


Asp Asp Glu Glu Glu Asp Asp Leu Glu Val Lys Glu Glu Asn Gly Val 
    50                  55                  60                  


Leu Val Leu Asn Asp Ala Asn Phe Asp Asn Phe Val Ala Asp Lys Asp 
65                  70                  75                  80  


Thr Val Leu Leu Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 
                85                  90                  95      


Phe Ala Pro Glu Tyr Glu Lys Ile Ala Asn Ile Leu Lys Asp Lys Asp 
            100                 105                 110         


Pro Pro Ile Pro Val Ala Lys Ile Asp Ala Thr Ser Ala Ser Val Leu 
        115                 120                 125             


Ala Ser Arg Phe Asp Val Ser Gly Tyr Pro Thr Ile Lys Ile Leu Lys 
    130                 135                 140                 


Lys Gly Gln Ala Val Asp Tyr Glu Gly Ser Arg Thr Gln Glu Glu Ile 
145                 150                 155                 160 


Val Ala Lys Val Arg Glu Val Ser Gln Pro Asp Trp Thr Pro Pro Pro 
                165                 170                 175     


Glu Val Thr Leu Val Leu Thr Lys Glu Asn Phe Asp Glu Val Val Asn 
            180                 185                 190         


Asp Ala Asp Ile Ile Leu Val Glu Phe Tyr Ala Pro Trp Cys Gly His 
        195                 200                 205             


Cys Lys Lys Leu Ala Pro Glu Tyr Glu Lys Ala Ala Lys Glu Leu Ser 
    210                 215                 220                 


Lys Arg Ser Pro Pro Ile Pro Leu Ala Lys Val Asp Ala Thr Ala Glu 
225                 230                 235                 240 


Thr Asp Leu Ala Lys Arg Phe Asp Val Ser Gly Tyr Pro Thr Leu Lys 
                245                 250                 255     


Ile Phe Arg Lys Gly Arg Pro Tyr Asp Tyr Asn Gly Pro Arg Glu Lys 
            260                 265                 270         


Tyr Gly Ile Val Asp Tyr Met Ile Glu Gln Ser Gly Pro Pro Ser Lys 
        275                 280                 285             


Glu Ile Leu Thr Leu Lys Gln Val Gln Glu Phe Leu Lys Asp Gly Asp 
    290                 295                 300                 


Asp Val Ile Ile Ile Gly Val Phe Lys Gly Glu Ser Asp Pro Ala Tyr 
305                 310                 315                 320 


Gln Gln Tyr Gln Asp Ala Ala Asn Asn Leu Arg Glu Asp Tyr Lys Phe 
                325                 330                 335     


His His Thr Phe Ser Thr Glu Ile Ala Lys Phe Leu Lys Val Ser Gln 
            340                 345                 350         


Gly Gln Leu Val Val Met Gln Pro Glu Lys Phe Gln Ser Lys Tyr Glu 
        355                 360                 365             


Pro Arg Ser His Met Met Asp Val Gln Gly Ser Thr Gln Asp Ser Ala 
    370                 375                 380                 


Ile Lys Asp Phe Val Leu Lys Tyr Ala Leu Pro Leu Val Gly His Arg 
385                 390                 395                 400 


Lys Val Ser Asn Asp Ala Lys Arg Tyr Thr Arg Arg Pro Leu Val Val 
                405                 410                 415     


Val Tyr Tyr Ser Val Asp Phe Ser Phe Asp Tyr Arg Ala Ala Thr Gln 
            420                 425                 430         


Phe Trp Arg Ser Lys Val Leu Glu Val Ala Lys Asp Phe Pro Glu Tyr 
        435                 440                 445             


Thr Phe Ala Ile Ala Asp Glu Glu Asp Tyr Ala Gly Glu Val Lys Asp 
    450                 455                 460                 


Leu Gly Leu Ser Glu Ser Gly Glu Asp Val Asn Ala Ala Ile Leu Asp 
465                 470                 475                 480 


Glu Ser Gly Lys Lys Phe Ala Met Glu Pro Glu Glu Phe Asp Ser Asp 
                485                 490                 495     


Thr Leu Arg Glu Phe Val Thr Ala Phe Lys Lys Gly Lys Leu Lys Pro 
            500                 505                 510         


Val Ile Lys Ser Gln Pro Val Pro Lys Asn Asn Lys Gly Pro Val Lys 
        515                 520                 525             


Val Val Val Gly Lys Thr Phe Asp Ser Ile Val Met Asp Pro Lys Lys 
    530                 535                 540                 


Asp Val Leu Ile Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 
545                 550                 555                 560 


Leu Glu Pro Val Tyr Asn Ser Leu Ala Lys Lys Tyr Lys Gly Gln Lys 
                565                 570                 575     


Gly Leu Val Ile Ala Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser 
            580                 585                 590         


Asp Arg Tyr Lys Val Glu Gly Phe Pro Thr Ile Tyr Phe Ala Pro Ser 
        595                 600                 605             


Gly Asp Lys Lys Asn Pro Val Lys Phe Glu Gly Gly Asp Arg Asp Leu 
    610                 615                 620                 


Glu His Leu Ser Lys Phe Ile Glu Glu His Ala Thr Lys Leu Ser Arg 
625                 630                 635                 640 


Thr Lys Glu Glu Leu 
                645 


<210>  17
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Thr Ala Thr Leu Arg Pro Tyr Leu Ser Ala Val Arg Ala Thr Leu 
1               5                   10                  15      


Gln Ala Ala Leu Cys Leu Glu Asn Phe Ser Ser Gln Val Val Glu Arg 
            20                  25                  30          


His Asn Lys Pro Glu Val Glu Val Arg Ser Ser Lys Glu Leu Leu Leu 
        35                  40                  45              


Gln Pro Val Thr Ile Ser Arg Asn Glu Lys Glu Lys Val Leu Ile Glu 
    50                  55                  60                  


Gly Ser Ile Asn Ser Val Arg Val Ser Ile Ala Val Lys Gln Ala Asp 
65                  70                  75                  80  


Glu Ile Glu Lys Ile Leu Cys His Lys Phe Met Arg Phe Met Met Met 
                85                  90                  95      


Arg Ala Glu Asn Phe Phe Ile Leu Arg Arg Lys Pro Val Glu Gly Tyr 
            100                 105                 110         


Asp Ile Ser Phe Leu Ile Thr Asn Phe His Thr Glu Gln Met Tyr Lys 
        115                 120                 125             


His Lys Leu Val Asp Phe Val Ile His Phe Met Glu Glu Ile Asp Lys 
    130                 135                 140                 


Glu Ile Ser Glu Met Lys Leu Ser Val Asn Ala Arg Ala Arg Ile Val 
145                 150                 155                 160 


Ala Glu Glu Phe Leu Lys Asn Phe 
                165             


<210>  18
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Ala Thr Leu Arg Pro Tyr Leu Ser Ala Val Arg Ala Thr Leu 
1               5                   10                  15      


Gln Ala Ala Leu Cys Leu Glu Asn Phe Ser Ser Gln Val Val Glu Arg 
            20                  25                  30          


His Asn Lys Pro Glu Val Glu Val Arg Ser Ser Lys Glu Leu Leu Leu 
        35                  40                  45              


Gln Pro Val Thr Ile Ser Arg Asn Glu Lys Glu Lys Val Leu Ile Glu 
    50                  55                  60                  


Gly Ser Ile Asn Ser Val Arg Val Ser Ile Ala Val Lys Gln Ala Asp 
65                  70                  75                  80  


Glu Ile Glu Lys Ile Leu Cys His Lys Phe Met Arg Phe Met Met Met 
                85                  90                  95      


Arg Ala Glu Asn Phe Phe Ile Leu Arg Arg Lys Pro Val Glu Gln Lys 
            100                 105                 110         


Lys Ile Phe Thr Ile Gln Gly Cys Tyr Pro Val Ile Arg Cys Leu Leu 
        115                 120                 125             


Arg Arg Arg Gly Trp Val Glu Lys Lys Met Val His Arg Ser Gly Pro 
    130                 135                 140                 


Thr Leu Leu Pro Pro Gln Lys Asp Leu Asp Ser Ser Ala Met Gly Asp 
145                 150                 155                 160 


Ser Asp Thr Thr Glu Asp Glu Asp Glu Asp Glu Asp Glu Glu Phe Gln 
                165                 170                 175     


Pro Ser Gln Leu Phe Asp Phe Asp Asp Leu Leu Lys Phe Asp Asp Leu 
            180                 185                 190         


Asp Gly Thr His Ala Leu Met Val Gly Leu Cys Leu Asn Leu Arg Asn 
        195                 200                 205             


Leu Pro Trp Phe Asp Glu Val Asp Ala Asn Ser Phe Phe Pro Arg Cys 
    210                 215                 220                 


Tyr Cys Leu Gly Ala Glu Asp Asp Lys Lys Ala Phe Ile Gly Asp Lys 
225                 230                 235                 240 


Gln Pro Lys Lys Gln Glu Lys Asn Pro Val Leu Val Ser Pro Glu Phe 
                245                 250                 255     


Val Asp Glu Ala Leu Cys Ala Cys Glu Glu Tyr Leu Ser Asn Leu Ala 
            260                 265                 270         


His Met Asp Ile Asp Lys Asp Leu Glu Ala Pro Leu Tyr Leu Thr Pro 
        275                 280                 285             


Glu Gly Trp Ser Leu Phe Leu Gln Arg Tyr Tyr Gln Val Val His Glu 
    290                 295                 300                 


Gly Ala Glu Leu Arg His Leu Asp Thr Gln Val Gln Arg Cys Glu Asp 
305                 310                 315                 320 


Ile Leu Gln Gln Leu Gln Ala Val Val Pro Gln Ile Asp Met Glu Gly 
                325                 330                 335     


Asp Arg Asn Ile Trp Ile Val Lys Pro Gly Ala Lys Ser Arg Gly Arg 
            340                 345                 350         


Gly Ile Met Cys Met Asp His Leu Glu Glu Met Leu Lys Leu Val Asn 
        355                 360                 365             


Gly Asn Pro Val Val Met Lys Asp Gly Lys Trp Val Val Gln Lys Tyr 
    370                 375                 380                 


Ile Glu Arg Pro Leu Leu Ile Phe Gly Thr Lys Phe Asp Leu Arg Gln 
385                 390                 395                 400 


Trp Phe Leu Val Thr Asp Trp Asn Pro Leu Thr Val Trp Phe Tyr Arg 
                405                 410                 415     


Asp Ser Tyr Ile Arg Phe Ser Thr Gln Pro Phe Ser Leu Lys Asn Leu 
            420                 425                 430         


Asp Asn Ser Val His Leu Cys Asn Asn Ser Ile Gln Lys His Leu Glu 
        435                 440                 445             


Asn Ser Cys His Arg His Pro Leu Leu Pro Pro Asp Asn Met Trp Ser 
    450                 455                 460                 


Ser Gln Arg Phe Gln Ala His Leu Gln Glu Met Gly Ala Pro Asn Ala 
465                 470                 475                 480 


Trp Ser Thr Ile Ile Val Pro Gly Met Lys Asp Ala Val Ile His Ala 
                485                 490                 495     


Leu Gln Thr Ser Gln Asp Thr Val Gln Cys Arg Lys Ala Ser Phe Glu 
            500                 505                 510         


Leu Tyr Gly Ala Asp Phe Val Phe Gly Glu Asp Phe Gln Pro Trp Leu 
        515                 520                 525             


Ile Glu Ile Asn Ala Ser Pro Thr Met Ala Pro Ser Thr Ala Val Thr 
    530                 535                 540                 


Ala Arg Leu Cys Ala Gly Val Gln Ala Asp Thr Leu Arg Val Val Ile 
545                 550                 555                 560 


Asp Arg Met Leu Asp Arg Asn Cys Asp Thr Gly Ala Phe Glu Leu Ile 
                565                 570                 575     


Tyr Lys Gln Pro Val Thr Thr Ser Pro Ala Ser Thr Pro Arg Pro Ser 
            580                 585                 590         


Cys Leu Leu Pro Met Tyr Ser Asp Thr Arg Ala Arg Ser Ser Asp Asp 
        595                 600                 605             


Ser Thr Ala Ser Trp Trp Ala Leu Arg Pro Cys Arg Pro Gln Ala Arg 
    610                 615                 620                 


Pro 
625 


<210>  19
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Val Arg Glu Pro Gly Pro Arg Pro Gly Thr Pro Gly Cys Ser Ala 
1               5                   10                  15      


Ser Gly Gln Trp Thr Ala Thr Leu Arg Pro Tyr Leu Ser Ala Val Arg 
            20                  25                  30          


Ala Thr Leu Gln Ala Ala Leu Cys Leu Glu Asn Phe Ser Ser Gln Val 
        35                  40                  45              


Val Glu Arg His Asn Lys Pro Glu Val Glu Val Arg Ser Ser Lys Glu 
    50                  55                  60                  


Leu Leu Leu Gln Pro Val Thr Ile Ser Arg Asn Glu Lys Glu Lys Val 
65                  70                  75                  80  


Leu Ile Glu Gly Ser Ile Asn Ser Val Arg Val Ser Ile Ala Val Lys 
                85                  90                  95      


Gln Ala Asp Glu Ile Glu Lys Ile Leu Cys His Lys Phe Met Arg Phe 
            100                 105                 110         


Met Met Met Arg Ala Glu Asn Phe Phe Ile Leu Arg Arg Lys Pro Val 
        115                 120                 125             


Glu Gly Tyr Asp Ile Ser Phe Leu Ile Thr Asn Phe His Thr Glu Gln 
    130                 135                 140                 


Met Tyr Lys His Lys Leu Val Asp Phe Val Ile His Phe Met Glu Glu 
145                 150                 155                 160 


Ile Asp Lys Glu Ile Ser Glu Met Lys Leu Ser Val Asn Ala Arg Ala 
                165                 170                 175     


Arg Ile Val Ala Glu Glu Phe Leu Lys Asn Phe 
            180                 185         


<210>  20
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Arg Phe Met Met Met Arg Ala Glu Asn Phe Phe Ile Leu Arg Arg 
1               5                   10                  15      


Lys Pro Val Glu Gly Tyr Asp Ile Ser Phe Leu Ile Thr Asn Phe His 
            20                  25                  30          


Thr Glu Gln Met Tyr Lys His Lys Leu Val Asp Phe Val Ile His Phe 
        35                  40                  45              


Met Glu Glu Ile Asp Lys Glu Ile Ser Glu Met Lys Leu Ser Val Asn 
    50                  55                  60                  


Ala Arg Ala Arg Ile Val Ala Glu Glu Phe Leu Lys Asn Phe 
65                  70                  75              


<210>  21
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Asp Ala Ala Ala Asp Pro Pro Gly Pro Ala Leu Pro Cys Glu 
1               5                   10                  15      


Phe Leu Arg Pro Gly Cys Gly Ala Pro Leu Ser Pro Gly Ala Gln Leu 
            20                  25                  30          


Gly Arg Gly Ala Pro Thr Ser Ala Phe Pro Pro Pro Ala Ala Glu Ala 
        35                  40                  45              


His Pro Ala Ala Arg Arg Gly Leu Arg Ser Pro Gln Leu Pro Ser Gly 
    50                  55                  60                  


Ala Met Ser Gln Asn Gly Ala Pro Gly Met Gln Glu Glu Ser Leu Gln 
65                  70                  75                  80  


Gly Ser Trp Val Glu Leu His Phe Ser Asn Asn Gly Asn Gly Gly Ser 
                85                  90                  95      


Val Pro Ala Ser Val Ser Ile Tyr Asn Gly Asp Met Glu Lys Ile Leu 
            100                 105                 110         


Leu Asp Ala Gln His Glu Ser Gly Arg Ser Ser Ser Lys Ser Ser His 
        115                 120                 125             


Cys Asp Ser Pro Pro Arg Ser Gln Thr Pro Gln Asp Thr Asn Arg Ala 
    130                 135                 140                 


Ser Glu Thr Asp Thr His Ser Ile Gly Glu Lys Asn Ser Ser Gln Ser 
145                 150                 155                 160 


Glu Glu Asp Asp Ile Glu Arg Arg Lys Glu Val Glu Ser Ile Leu Lys 
                165                 170                 175     


Lys Asn Ser Asp Trp Ile Trp Asp Trp Ser Ser Arg Pro Glu Asn Ile 
            180                 185                 190         


Pro Pro Lys Glu Phe Leu Phe Lys His Pro Lys Arg Thr Ala Thr Leu 
        195                 200                 205             


Ser Met Arg Asn Thr Ser Val Met Lys Lys Gly Gly Ile Phe Ser Ala 
    210                 215                 220                 


Glu Phe Leu Lys Val Phe Leu Pro Ser Leu Leu Leu Ser His Leu Leu 
225                 230                 235                 240 


Ala Ile Gly Leu Gly Ile Tyr Ile Gly Arg Arg Leu Thr Thr Ser Thr 
                245                 250                 255     


Ser Thr Phe 
            


<210>  22
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Pro Lys Lys Glu Lys Met Ala Lys Thr Pro Leu Ser Asp Glu Lys 
1               5                   10                  15      


Gln Leu Leu Leu Phe Gln Gln Lys Leu Leu Ala Glu Glu Glu Met Ala 
            20                  25                  30          


Lys Lys Lys Glu Arg Leu Leu Ser Gln Phe Leu Lys Asp Lys Leu Ala 
        35                  40                  45              


Lys Glu Glu His Asn Ser Ala Leu Asn Leu Asn Lys Ile Asn Thr Gln 
    50                  55                  60                  


Trp Arg Thr Val Leu Arg Glu Val Lys Thr Arg Glu Leu His Lys Asp 
65                  70                  75                  80  


Ile Glu Ile Leu Ser Gln Thr Phe Glu Arg Val Val Asp Cys Lys Asp 
                85                  90                  95      


Asn Val Ile Lys Ser Leu Ala Lys Asp Leu Ser Glu Ala Glu Glu Gln 
            100                 105                 110         


Tyr Ala His Ala Leu Arg Ser His Leu His Asn Val Asp Gln Leu Leu 
        115                 120                 125             


Ala Leu Gln Arg His Arg Leu Ser Leu Leu Glu Glu Ser Tyr Asn Met 
    130                 135                 140                 


Glu Leu Glu Ala Leu Thr Lys Glu Phe Glu Thr Glu Arg Lys Thr Ile 
145                 150                 155                 160 


Ile Asp Gln His Glu Lys Glu Ile His Tyr Leu Gln Asp Ile Phe Met 
                165                 170                 175     


Ala Met Glu Gln Asn Tyr Ile Asp Ser Glu Tyr Glu Ser Lys Leu Glu 
            180                 185                 190         


Phe Gln Ser Met Trp Asn Asp Leu Lys Asn Met Asn Leu Glu Glu Lys 
        195                 200                 205             


His Phe Leu Arg Leu His Leu Glu Asn Arg Val Glu Asp Leu Trp Arg 
    210                 215                 220                 


Lys Phe Gln Asp Val Leu Lys Asn Tyr Thr Asp Ala Thr Glu Asp Arg 
225                 230                 235                 240 


Lys Ala Ala Phe Glu Thr Leu Gln Val Lys Asp Glu Lys Ser Ser Lys 
                245                 250                 255     


Glu Ile Glu Val Gln Met Lys Lys Ile Gln Lys Leu Gln Asp Ala Ile 
            260                 265                 270         


Thr Ile Ser Lys Gly Lys Ile Met Ile His Ser Arg Glu Ser Glu Asp 
        275                 280                 285             


Glu Asn Arg Tyr Ile Arg Asn Asp Lys Glu Leu Val Leu Val Gln Leu 
    290                 295                 300                 


Arg Lys Leu Lys Ala Gln Arg Thr Gln Ala Arg Ala Ala Ser Gln Lys 
305                 310                 315                 320 


Asn Leu Val Arg Leu Thr Leu Glu Ser Asn Ala Thr Leu Lys Ala Leu 
                325                 330                 335     


Arg Lys Ile Val Asp Lys Gly Glu Lys Ile Leu Lys Leu Ala Glu Ile 
            340                 345                 350         


Cys Arg Lys Phe Glu Thr Glu Glu Glu Lys Val Leu Pro Phe Tyr Ser 
        355                 360                 365             


Ser Val Leu Thr Pro Lys Glu Gln Glu Gly Ile Gln Lys Asn Asn Leu 
    370                 375                 380                 


Glu Glu Leu Thr Glu Glu Leu Thr Lys Val Met Val Asp Tyr Ile Gly 
385                 390                 395                 400 


Met Glu Asn Phe Trp Lys Arg Tyr Asn Lys Val Lys Leu Glu Gln Leu 
                405                 410                 415     


Ser Leu Gln His Arg Arg Ala Gln Leu Leu Asp Ile Asn Gly Lys Leu 
            420                 425                 430         


Arg Glu Met Leu Lys Gln Tyr Leu Asp Gly Ile Ser Val Ser Asp Glu 
        435                 440                 445             


Val Leu Ser Gln Leu Asn Pro Leu Phe Ile Val Asn Tyr Gln Ser Asn 
    450                 455                 460                 


Leu Leu Gln Pro Leu Ser Ile Arg Ile Ala His Pro Gly Asp Lys Gln 
465                 470                 475                 480 


His Pro Thr Thr 
                


<210>  23
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Pro Lys Lys Glu Lys Met Ala Lys Thr Pro Leu Ser Asp Glu Lys 
1               5                   10                  15      


Gln Leu Leu Leu Phe Gln Gln Lys Leu Leu Ala Glu Glu Glu Met Ala 
            20                  25                  30          


Lys Lys Lys Glu Arg Leu Leu Ser Gln Phe Leu Lys Asp Lys Leu Ala 
        35                  40                  45              


Lys Glu Glu His Asn Ser Ala Leu Asn Leu Asn Lys Ile Asn Thr Gln 
    50                  55                  60                  


Trp Arg Thr Val Leu Arg Glu Val Lys Thr Arg Glu Leu His Lys Asp 
65                  70                  75                  80  


Ile Glu Ile Leu Ser Gln Thr Phe Glu Arg Val Val Asp Cys Lys Asp 
                85                  90                  95      


Asn Val Ile Lys Ser Leu Ala Lys Asp Leu Ser Glu Ala Glu Glu Gln 
            100                 105                 110         


Tyr Ala His Ala Leu Arg Ser His Leu His Asn Val Asp Gln Leu Leu 
        115                 120                 125             


Ala Leu Gln Arg His Arg Leu Ser Leu Leu Glu Glu Ser Tyr Asn Met 
    130                 135                 140                 


Glu Leu Glu Ala Leu Thr Lys Glu Phe Glu Thr Glu Arg Lys Thr Ile 
145                 150                 155                 160 


Ile Asp Gln His Glu Lys Glu Ile His Tyr Leu Gln Asp Ile Phe Met 
                165                 170                 175     


Ala Met Glu Gln Asn Tyr Ile Asp Ser Glu Tyr Glu Ser Lys Leu Glu 
            180                 185                 190         


Phe Gln Ser Met Trp Asn Asp Leu Lys Asn Met Asn Leu Glu Glu Lys 
        195                 200                 205             


His Phe Leu Arg Leu His Leu Glu Asn Arg Val Glu Asp Leu Trp Arg 
    210                 215                 220                 


Lys Phe Gln Asp Val Leu Lys Asn Tyr Thr Asp Ala Thr Glu Asp Arg 
225                 230                 235                 240 


Lys Ala Ala Phe Glu Thr Leu Gln Val Lys Asp Glu Lys Ser Ser Lys 
                245                 250                 255     


Glu Ile Glu Val Gln Met Lys Lys Ile Gln Lys Leu Gln Asp Ala Ile 
            260                 265                 270         


Thr Ile Ser Lys Gly Lys Ile Met Ile His Ser Arg Glu Ser Glu Asp 
        275                 280                 285             


Glu Asn Arg Tyr Ile Arg Asn Asp Lys Glu Leu Val Leu Val Gln Leu 
    290                 295                 300                 


Arg Lys Leu Lys Ala Gln Arg Thr Gln Ala Arg Ala Ala Ser Gln Lys 
305                 310                 315                 320 


Asn Leu Val Arg Leu Thr Leu Glu Ser Asn Ala Thr Leu Lys Ala Leu 
                325                 330                 335     


Arg Lys Ile Val Asp Lys Gly Glu Lys Ile Leu Lys Leu Ala Glu Ile 
            340                 345                 350         


Cys Arg Lys Phe Glu Thr Glu Glu Glu Lys Val Leu Pro Phe Tyr Ser 
        355                 360                 365             


Ser Val Leu Thr Pro Lys Glu Gln Glu Gly Ile Gln Lys Asn Asn Leu 
    370                 375                 380                 


Glu Glu Leu Thr Glu Glu Leu Thr Lys Val Met Val Asp Tyr Ile Gly 
385                 390                 395                 400 


Met Glu Asn Phe Trp Lys Arg Tyr Asn Lys Val Lys Leu Glu Gln Leu 
                405                 410                 415     


Ser Leu Gln His Arg Arg Ala Gln Leu Leu Asp Ile Asn Gly Lys Leu 
            420                 425                 430         


Arg Glu Met Leu Lys Gln Tyr Leu Asp Gly Ile Ser Val Ser Asp Glu 
        435                 440                 445             


Val Leu Ser Gln Leu Asn Pro Leu Phe Ile Val Asn Tyr Gln Ser Asn 
    450                 455                 460                 


Leu Leu Gln Pro Leu Ser Ile Arg Ile Ala His Pro Gly Ser Thr Ser 
465                 470                 475                 480 


Pro Ser Ala Pro Trp Arg Asp Gln Arg Arg Ser Phe Phe Leu Gly Ser 
                485                 490                 495     


Ser 
    


<210>  24
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Glu Glu Gln Pro Gln Met Gln Asp Ala Asp Glu Pro Ala Asp Ser 
1               5                   10                  15      


Gly Gly Glu Gly Arg Ala Gly Gly Pro Pro Gln Val Ala Gly Ala Gln 
            20                  25                  30          


Ala Ala Cys Ser Glu Asp Arg Met Thr Leu Leu Leu Arg Leu Arg Ala 
        35                  40                  45              


Gln Thr Lys Gln Gln Leu Leu Glu Tyr Lys Ser Met Val Asp Ala Ser 
    50                  55                  60                  


Glu Glu Lys Thr Pro Glu Gln Ile Met Gln Glu Lys Gln Ile Glu Ala 
65                  70                  75                  80  


Lys Ile Glu Asp Leu Glu Asn Glu Ile Glu Glu Val Lys Val Ala Phe 
                85                  90                  95      


Glu Ile Lys Lys Leu Ala Leu Asp Arg Met Arg Leu Ser Thr Ala Leu 
            100                 105                 110         


Lys Lys Asn Leu Glu Lys Ile Ser Arg Gln Ser Ser Val Leu Met Asp 
        115                 120                 125             


Asn Met Lys His Leu Leu Glu Leu Asn Lys Leu Ile Met Lys Ser Gln 
    130                 135                 140                 


Gln Glu Ser Trp Asp Leu Glu Glu Lys Leu Leu Asp Ile Arg Lys Lys 
145                 150                 155                 160 


Arg Leu Gln Leu Lys Gln Ala Ser Glu Ser Lys Leu Leu Glu Ile Gln 
                165                 170                 175     


Thr Glu Lys Asn Lys Gln Lys Ile Asp Leu Asp Ser Met Glu Asn Ser 
            180                 185                 190         


Glu Arg Ile Lys Ile Ile Arg Gln Asn Leu Gln Met Glu Ile Lys Ile 
        195                 200                 205             


Thr Thr Val Ile Gln His Val Phe Gln Asn Leu Ile Leu Gly Ser Lys 
    210                 215                 220                 


Val Asn Trp Ala Glu Asp Pro Ala Leu Lys Glu Ile Val Leu Gln Leu 
225                 230                 235                 240 


Glu Lys Asn Val Asp Met Met 
                245         


<210>  25
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Ala Gly Ala Gly Ala Gly Ser Ala Pro Arg Trp Leu Arg Ala 
1               5                   10                  15      


Leu Ser Glu Pro Leu Ser Ala Ala Gln Leu Arg Arg Leu Glu Glu His 
            20                  25                  30          


Arg Tyr Ser Ala Ala Gly Val Ser Leu Leu Glu Pro Pro Leu Gln Leu 
        35                  40                  45              


Tyr Trp Thr Trp Leu Leu Gln Trp Ile Pro Leu Trp Met Ala Pro Asn 
    50                  55                  60                  


Ser Ile Thr Leu Leu Gly Leu Ala Val Asn Val Val Thr Thr Leu Val 
65                  70                  75                  80  


Leu Ile Ser Tyr Cys Pro Thr Ala Thr Glu Glu Ala Pro Tyr Trp Thr 
                85                  90                  95      


Tyr Leu Leu Cys Ala Leu Gly Leu Phe Ile Tyr Gln Ser Leu Asp Ala 
            100                 105                 110         


Ile Asp Gly Lys Gln Ala Arg Arg Thr Asn Ser Cys Ser Pro Leu Gly 
        115                 120                 125             


Glu Leu Phe Asp His Gly Cys Asp Ser Leu Ser Thr Val Phe Met Ala 
    130                 135                 140                 


Val Gly Ala Ser Ile Ala Ala Arg Leu Gly Thr Tyr Pro Asp Trp Phe 
145                 150                 155                 160 


Phe Phe Cys Ser Phe Ile Gly Met Phe Val Phe Tyr Cys Ala His Trp 
                165                 170                 175     


Gln Thr Tyr Val Ser Gly Met Leu Arg Phe Gly Lys Val Asp Val Thr 
            180                 185                 190         


Glu Ile Gln Ile Ala Leu Val Ile Val Phe Val Leu Ser Ala Phe Gly 
        195                 200                 205             


Gly Ala Thr Met Trp Asp Tyr Thr Ile Pro Ile Leu Glu Ile Lys Leu 
    210                 215                 220                 


Lys Ile Leu Pro Val Leu Gly Phe Leu Gly Gly Val Ile Phe Ser Cys 
225                 230                 235                 240 


Ser Asn Tyr Phe His Val Ile Leu His Gly Gly Val Gly Lys Asn Gly 
                245                 250                 255     


Ser Thr Ile Ala Gly Thr Ser Val Leu Ser Pro Gly Leu His Ile Gly 
            260                 265                 270         


Leu Ile Ile Ile Leu Ala Ile Met Ile Tyr Lys Lys Ser Ala Thr Asp 
        275                 280                 285             


Val Phe Glu Lys His Pro Cys Leu Tyr Ile Leu Met Phe Gly Cys Val 
    290                 295                 300                 


Phe Ala Lys Val Ser Gln Lys Leu Val Val Ala His Met Thr Lys Ser 
305                 310                 315                 320 


Glu Leu Tyr Leu Gln Asp Thr Val Phe Leu Gly Pro Gly Leu Leu Phe 
                325                 330                 335     


Leu Asp Gln Tyr Phe Asn Asn Phe Ile Asp Glu Tyr Val Val Leu Trp 
            340                 345                 350         


Met Ala Met Val Ile Ser Ser Phe Asp Met Val Ile Tyr Phe Ser Ala 
        355                 360                 365             


Leu Cys Leu Gln Ile Ser Arg His Leu His Leu Asn Ile Phe Lys Thr 
    370                 375                 380                 


Ala Cys His Gln Ala Pro Glu Gln Val Gln Val Leu Ser Ser Lys Ser 
385                 390                 395                 400 


His Gln Asn Asn Met Asp 
                405     


<210>  26
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Ala Gly Ala Gly Ala Gly Ser Ala Pro Arg Trp Leu Arg Ala 
1               5                   10                  15      


Leu Ser Glu Pro Leu Ser Ala Ala Gln Leu Arg Arg Leu Glu Glu His 
            20                  25                  30          


Arg Tyr Ser Ala Ala Gly Val Ser Leu Leu Glu Pro Pro Leu Gln Leu 
        35                  40                  45              


Tyr Trp Thr Trp Leu Leu Gln Trp Ile Pro Leu Trp Met Ala Pro Asn 
    50                  55                  60                  


Ser Ile Thr Leu Leu Gly Leu Ala Val Asn Val Val Thr Thr Leu Val 
65                  70                  75                  80  


Leu Ile Ser Tyr Cys Pro Thr Ala Thr Glu Glu Ala Pro Tyr Trp Thr 
                85                  90                  95      


Tyr Leu Leu Cys Ala Leu Gly Leu Phe Ile Tyr Gln Ser Leu Asp Ala 
            100                 105                 110         


Ile Asp Gly Lys Gln Ala Arg Arg Thr Asn Ser Cys Ser Pro Leu Gly 
        115                 120                 125             


Glu Leu Phe Asp His Gly Cys Asp Ser Leu Ser Thr Val Phe Met Ala 
    130                 135                 140                 


Val Gly Ala Ser Ile Ala Ala Arg Leu Gly Thr Tyr Pro Asp Trp Phe 
145                 150                 155                 160 


Phe Phe Cys Ser Phe Ile Gly Met Phe Val Phe Tyr Cys Ala His Trp 
                165                 170                 175     


Gln Thr Tyr Val Ser Gly Met Leu Arg Phe Gly Lys Val Asp Val Thr 
            180                 185                 190         


Glu Ile Gln Ile Ala Leu Val Ile Val Phe Val Leu Ser Ala Phe Gly 
        195                 200                 205             


Gly Ala Thr Met Trp Asp Tyr Thr Phe Ser 
    210                 215             


<210>  27
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Glu Leu Ser Glu Ser Val Gln Lys Gly Phe Gln Met Leu Ala Asp 
1               5                   10                  15      


Pro Arg Ser Phe Asp Ser Asn Ala Phe Thr Leu Leu Leu Arg Ala Ala 
            20                  25                  30          


Phe Gln Ser Leu Leu Asp Ala Gln Ala Asp Glu Ala Val Leu Asp His 
        35                  40                  45              


Pro Asp Leu Lys His Ile Asp Pro Val Val Leu Lys His Cys His Ala 
    50                  55                  60                  


Ala Ala Ala Thr Tyr Ile Leu Glu Ala Gly Lys His Arg Ala Asp Lys 
65                  70                  75                  80  


Ser Thr Leu Ser Thr Tyr Leu Glu Asp Cys Lys Phe Asp Arg Glu Arg 
                85                  90                  95      


Ile Glu Leu Phe Cys Thr Glu Tyr Gln Asn Asn Lys Asn Ser Leu Glu 
            100                 105                 110         


Ile Leu Leu Gly Ser Ile Gly Arg Ser Leu Pro His Ile Thr Asp Val 
        115                 120                 125             


Ser Trp Arg Leu Glu Tyr Gln Ile Lys Thr Asn Gln Leu His Arg Met 
    130                 135                 140                 


Tyr Arg Pro Ala Tyr Leu Val Thr Leu Ser Val Gln Asn Thr Asp Ser 
145                 150                 155                 160 


Pro Ser Tyr Pro Glu Ile Ser Phe Ser Cys Ser Met Glu Gln Leu Gln 
                165                 170                 175     


Asp Leu Val Gly Lys Leu Lys Asp Ala Ser Lys Ser Leu Glu Arg Ala 
            180                 185                 190         


Thr Gln Leu 
        195 


<210>  28
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Ser Ser Ser Gly Asn Asp Asp Asp Leu Thr Ile Pro Arg Ala 
1               5                   10                  15      


Ala Ile Asn Lys Met Ile Lys Glu Thr Leu Pro Asn Val Arg Val Ala 
            20                  25                  30          


Asn Asp Ala Arg Glu Leu Val Val Asn Cys Cys Thr Glu Phe Ile His 
        35                  40                  45              


Leu Ile Ser Ser Glu Ala Asn Glu Ile Cys Asn Lys Ser Glu Lys Lys 
    50                  55                  60                  


Thr Ile Ser Pro Glu His Val Ile Gln Ala Leu Glu Ser Leu Gly Phe 
65                  70                  75                  80  


Gly Ser Tyr Ile Ser Glu Val Lys Glu Val Leu Gln Glu Cys Lys Thr 
                85                  90                  95      


Val Ala Leu Lys Arg Arg Lys Ala Ser Ser Arg Leu Glu Asn Leu Gly 
            100                 105                 110         


Ile Pro Glu Glu Glu Leu Leu Arg Gln Gln Gln Glu Leu Phe Ala Lys 
        115                 120                 125             


Ala Arg Gln Gln Gln Ala Glu Leu Ala Gln Gln Glu Trp Leu Gln Met 
    130                 135                 140                 


Gln Gln Ala Ala Gln Gln Ala Gln Leu Ala Ala Ala Ser Ala Ser Ala 
145                 150                 155                 160 


Ser Asn Gln Ala Gly Ser Ser Gln Asp Glu Glu Asp Asp Asp Asp Ile 
                165                 170                 175     


<210>  29
<211>  961
<212>  PRT
<213>  Homo sapiens

<400>  29

Met His Gly His Arg Ala Pro Gly Gly Ala Gly Pro Ser Glu Pro Glu 
1               5                   10                  15      


His Pro Ala Thr Asn Pro Pro Gly Ala Ala Pro Pro Ala Cys Ala Asp 
            20                  25                  30          


Ser Asp Pro Gly Ala Ser Glu Pro Gly Leu Leu Ala Arg Arg Gly Ser 
        35                  40                  45              


Gly Ser Ala Leu Gly Gly Pro Leu Asp Pro Gln Phe Val Gly Pro Ser 
    50                  55                  60                  


Asp Thr Ser Leu Gly Ala Ala Pro Gly His Arg Val Leu Pro Cys Gly 
65                  70                  75                  80  


Pro Ser Pro Gln His His Arg Ala Leu Arg Phe Ser Tyr His Leu Glu 
                85                  90                  95      


Gly Ser Gln Pro Arg Pro Gly Leu His Gln Gly Asn Arg Ile Leu Val 
            100                 105                 110         


Lys Ser Leu Ser Leu Asp Pro Gly Gln Ser Leu Glu Pro His Pro Glu 
        115                 120                 125             


Gly Pro Gln Arg Leu Arg Ser Asp Pro Gly Pro Pro Thr Glu Thr Pro 
    130                 135                 140                 


Ser Gln Arg Pro Ser Pro Leu Lys Arg Ala Pro Gly Pro Lys Pro Gln 
145                 150                 155                 160 


Val Pro Pro Lys Pro Ser Tyr Leu Gln Met Pro Arg Met Pro Pro Pro 
                165                 170                 175     


Leu Glu Pro Ile Pro Pro Pro Pro Ser Arg Pro Leu Pro Ala Asp Pro 
            180                 185                 190         


Arg Val Ala Lys Gly Leu Ala Pro Arg Ala Glu Ala Ser Pro Ser Ser 
        195                 200                 205             


Ala Ala Val Ser Ser Leu Ile Glu Lys Phe Glu Arg Glu Pro Val Ile 
    210                 215                 220                 


Val Ala Ser Asp Arg Pro Val Pro Gly Pro Ser Pro Gly Pro Pro Glu 
225                 230                 235                 240 


Pro Val Met Leu Pro Gln Pro Thr Ser Gln Pro Pro Val Pro Gln Leu 
                245                 250                 255     


Pro Glu Gly Glu Ala Ser Arg Cys Leu Phe Leu Leu Ala Pro Gly Pro 
            260                 265                 270         


Arg Asp Gly Glu Lys Val Pro Asn Arg Asp Ser Gly Ile Asp Ser Ile 
        275                 280                 285             


Ser Ser Pro Ser Asn Ser Glu Glu Thr Cys Phe Val Ser Asp Asp Gly 
    290                 295                 300                 


Pro Pro Ser His Ser Leu Cys Pro Gly Pro Pro Ala Leu Ala Ser Val 
305                 310                 315                 320 


Pro Val Ala Leu Ala Asp Pro His Arg Pro Gly Ser Gln Glu Val Asp 
                325                 330                 335     


Ser Asp Leu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu Glu Lys Asp 
            340                 345                 350         


Arg Glu Ile Pro Val Pro Leu Met Glu Arg Gln Glu Ser Val Glu Leu 
        355                 360                 365             


Thr Val Gln Gln Lys Val Phe His Ile Ala Asn Glu Leu Leu Gln Thr 
    370                 375                 380                 


Glu Lys Ala Tyr Val Ser Arg Leu His Leu Leu Asp Gln Val Phe Cys 
385                 390                 395                 400 


Ala Arg Leu Leu Glu Glu Ala Arg Asn Arg Ser Ser Phe Pro Ala Asp 
                405                 410                 415     


Val Val His Gly Ile Phe Ser Asn Ile Cys Ser Ile Tyr Cys Phe His 
            420                 425                 430         


Gln Gln Phe Leu Leu Pro Glu Leu Glu Lys Arg Met Glu Glu Trp Asp 
        435                 440                 445             


Arg Tyr Pro Arg Ile Gly Asp Ile Leu Gln Lys Leu Ala Pro Phe Leu 
    450                 455                 460                 


Lys Met Tyr Gly Glu Tyr Val Lys Asn Phe Asp Arg Ala Val Glu Leu 
465                 470                 475                 480 


Val Asn Thr Trp Thr Glu Arg Ser Thr Gln Phe Lys Val Ile Ile His 
                485                 490                 495     


Glu Val Gln Lys Glu Glu Ala Cys Gly Asn Leu Thr Leu Gln His His 
            500                 505                 510         


Met Leu Glu Pro Val Gln Arg Ile Pro Arg Tyr Glu Leu Leu Leu Lys 
        515                 520                 525             


Asp Tyr Leu Leu Lys Leu Pro His Gly Ser Pro Asp Ser Lys Asp Ala 
    530                 535                 540                 


Gln Lys Ser Leu Glu Leu Ile Ala Thr Ala Ala Glu His Ser Asn Ala 
545                 550                 555                 560 


Ala Ile Arg Lys Met Glu Arg Met His Lys Leu Leu Lys Val Tyr Glu 
                565                 570                 575     


Leu Leu Gly Gly Glu Glu Asp Ile Val Ser Pro Thr Lys Glu Leu Ile 
            580                 585                 590         


Lys Glu Gly His Ile Leu Lys Leu Ser Ala Lys Asn Gly Thr Thr Gln 
        595                 600                 605             


Asp Arg Tyr Leu Ile Leu Phe Asn Asp Arg Leu Leu Tyr Cys Val Pro 
    610                 615                 620                 


Arg Leu Arg Leu Leu Gly Gln Lys Phe Ser Val Arg Ala Arg Ile Asp 
625                 630                 635                 640 


Val Asp Gly Met Glu Leu Lys Glu Ser Ser Asn Leu Asn Leu Pro Arg 
                645                 650                 655     


Thr Phe Leu Val Ser Gly Lys Gln Arg Ser Leu Glu Leu Gln Ala Arg 
            660                 665                 670         


Thr Glu Glu Glu Lys Lys Asp Trp Val Gln Ala Ile Asn Ser Thr Leu 
        675                 680                 685             


Leu Lys His Glu Gln Thr Leu Glu Thr Phe Lys Leu Leu Asn Ser Thr 
    690                 695                 700                 


Asn Arg Glu Asp Glu Asp Thr Pro Pro Asn Ser Pro Asn Val Asp Leu 
705                 710                 715                 720 


Gly Lys Arg Ala Pro Thr Pro Ile Arg Glu Lys Glu Val Thr Met Cys 
                725                 730                 735     


Met Arg Cys Gln Glu Pro Phe Asn Ser Ile Thr Lys Arg Arg His His 
            740                 745                 750         


Cys Lys Ala Cys Gly His Val Val Cys Gly Lys Cys Ser Glu Phe Arg 
        755                 760                 765             


Ala Arg Leu Val Tyr Asp Asn Asn Arg Ser Asn Arg Val Cys Thr Asp 
    770                 775                 780                 


Cys Tyr Val Ala Leu His Gly Val Pro Gly Ser Ser Pro Ala Cys Ser 
785                 790                 795                 800 


Gln His Thr Pro Gln Arg Arg Arg Ser Ile Leu Glu Lys Gln Ala Ser 
                805                 810                 815     


Val Ala Ala Glu Asn Ser Val Ile Cys Ser Phe Leu His Tyr Met Glu 
            820                 825                 830         


Lys Gly Gly Lys Gly Trp His Lys Ala Trp Phe Val Val Pro Glu Asn 
        835                 840                 845             


Glu Pro Leu Val Leu Tyr Ile Tyr Gly Ala Pro Gln Asp Val Lys Ala 
    850                 855                 860                 


Gln Arg Ser Leu Pro Leu Ile Gly Phe Glu Val Gly Pro Pro Glu Ala 
865                 870                 875                 880 


Gly Glu Arg Pro Asp Arg Arg His Val Phe Lys Ile Thr Gln Ser His 
                885                 890                 895     


Leu Ser Trp Tyr Phe Ser Pro Glu Thr Glu Glu Leu Gln Arg Arg Trp 
            900                 905                 910         


Met Ala Val Leu Gly Arg Ala Gly Arg Gly Asp Thr Phe Cys Pro Gly 
        915                 920                 925             


Pro Thr Leu Ser Glu Asp Arg Glu Met Glu Glu Ala Pro Val Ala Ala 
    930                 935                 940                 


Leu Gly Ala Thr Ala Glu Pro Pro Glu Ser Pro Gln Thr Arg Asp Lys 
945                 950                 955                 960 


Thr 
    


<210>  30
<211>  674
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gln Thr Ser Ser Ser Arg Ser Val His Leu Ser Glu Trp Gln Lys 
1               5                   10                  15      


Asn Tyr Phe Ala Ile Thr Ser Gly Ile Cys Thr Gly Pro Lys Ala Asp 
            20                  25                  30          


Ala Tyr Arg Ala Gln Ile Leu Arg Ile Gln Tyr Ala Trp Ala Asn Ser 
        35                  40                  45              


Glu Ile Ser Gln Val Cys Ala Thr Lys Leu Phe Lys Lys Tyr Ala Glu 
    50                  55                  60                  


Lys Tyr Ser Ala Ile Ile Asp Ser Asp Asn Val Glu Ser Gly Leu Asn 
65                  70                  75                  80  


Asn Tyr Ala Glu Asn Ile Leu Thr Leu Ala Gly Ser Gln Gln Thr Asp 
                85                  90                  95      


Ser Asp Lys Trp Gln Ser Gly Leu Ser Ile Asn Asn Val Phe Lys Met 
            100                 105                 110         


Ser Ser Val Gln Lys Met Met Gln Ala Gly Lys Lys Phe Lys Asp Ser 
        115                 120                 125             


Leu Leu Glu Pro Ala Leu Ala Ser Val Val Ile His Lys Glu Ala Thr 
    130                 135                 140                 


Val Phe Asp Leu Pro Lys Phe Ser Val Cys Gly Ser Ser Gln Glu Ser 
145                 150                 155                 160 


Asp Ser Leu Pro Asn Ser Ala His Asp Arg Asp Arg Thr Gln Asp Phe 
                165                 170                 175     


Pro Glu Ser Asn Arg Leu Lys Leu Leu Gln Asn Ala Gln Pro Pro Met 
            180                 185                 190         


Val Thr Asn Thr Ala Arg Thr Cys Pro Thr Phe Ser Ala Pro Val Gly 
        195                 200                 205             


Glu Ser Ala Thr Ala Lys Phe His Val Thr Pro Leu Phe Gly Asn Val 
    210                 215                 220                 


Lys Lys Glu Asn His Ser Ser Ala Lys Glu Asn Ile Gly Leu Asn Val 
225                 230                 235                 240 


Phe Leu Ser Asn Gln Ser Cys Phe Pro Ala Ala Cys Glu Asn Pro Gln 
                245                 250                 255     


Arg Lys Ser Phe Tyr Gly Ser Gly Thr Ile Asp Ala Leu Ser Asn Pro 
            260                 265                 270         


Ile Leu Asn Lys Ala Cys Ser Lys Thr Glu Asp Asn Gly Pro Lys Glu 
        275                 280                 285             


Asp Ser Ser Leu Pro Thr Phe Lys Thr Ala Lys Glu Gln Leu Trp Val 
    290                 295                 300                 


Asp Gln Gln Lys Lys Tyr His Gln Pro Gln Arg Ala Ser Gly Ser Ser 
305                 310                 315                 320 


Tyr Gly Gly Val Lys Lys Ser Leu Gly Ala Ser Arg Ser Arg Gly Ile 
                325                 330                 335     


Leu Gly Lys Phe Val Pro Pro Ile Pro Lys Gln Asp Gly Gly Glu Gln 
            340                 345                 350         


Asn Gly Gly Met Gln Cys Lys Pro Tyr Gly Ala Gly Pro Thr Glu Pro 
        355                 360                 365             


Ala His Pro Val Asp Glu Arg Leu Lys Asn Leu Glu Pro Lys Met Ile 
    370                 375                 380                 


Glu Leu Ile Met Asn Glu Ile Met Asp His Gly Pro Pro Val Asn Trp 
385                 390                 395                 400 


Glu Asp Ile Ala Gly Val Glu Phe Ala Lys Ala Thr Ile Lys Glu Ile 
                405                 410                 415     


Val Val Trp Pro Met Leu Arg Pro Asp Ile Phe Thr Gly Leu Arg Gly 
            420                 425                 430         


Pro Pro Lys Gly Ile Leu Leu Phe Gly Pro Pro Gly Thr Gly Lys Thr 
        435                 440                 445             


Leu Ile Gly Lys Cys Ile Ala Ser Gln Ser Gly Ala Thr Phe Phe Ser 
    450                 455                 460                 


Ile Ser Ala Ser Ser Leu Thr Ser Lys Trp Val Gly Glu Gly Glu Lys 
465                 470                 475                 480 


Met Val Arg Ala Leu Phe Ala Val Ala Arg Cys Gln Gln Pro Ala Val 
                485                 490                 495     


Ile Phe Ile Asp Glu Ile Asp Ser Leu Leu Ser Gln Arg Gly Asp Gly 
            500                 505                 510         


Glu His Glu Ser Ser Arg Arg Ile Lys Thr Glu Phe Leu Val Gln Leu 
        515                 520                 525             


Asp Gly Ala Thr Thr Ser Ser Glu Asp Arg Ile Leu Val Val Gly Ala 
    530                 535                 540                 


Thr Asn Arg Pro Gln Glu Ile Asp Glu Ala Ala Arg Arg Arg Leu Val 
545                 550                 555                 560 


Lys Arg Leu Tyr Ile Pro Leu Pro Glu Ala Ser Ala Arg Lys Gln Ile 
                565                 570                 575     


Val Ile Asn Leu Met Ser Lys Glu Gln Cys Cys Leu Ser Glu Glu Glu 
            580                 585                 590         


Ile Glu Gln Ile Val Gln Gln Ser Asp Ala Phe Ser Gly Ala Asp Met 
        595                 600                 605             


Thr Gln Leu Cys Arg Glu Ala Ser Leu Gly Pro Ile Arg Ser Leu Gln 
    610                 615                 620                 


Thr Ala Asp Ile Ala Thr Ile Thr Pro Asp Gln Val Arg Pro Ile Ala 
625                 630                 635                 640 


Tyr Ile Asp Phe Glu Asn Ala Phe Arg Thr Val Arg Pro Ser Val Ser 
                645                 650                 655     


Pro Lys Asp Leu Glu Leu Tyr Glu Asn Trp Asn Lys Thr Phe Gly Cys 
            660                 665                 670         


Gly Lys 
        


<210>  31
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ser Ser Val Gln Lys Met Met Gln Ala Gly Lys Lys Phe Lys Asp 
1               5                   10                  15      


Ser Leu Leu Glu Pro Ala Leu Ala Ser Val Val Ile His Lys Glu Ala 
            20                  25                  30          


Thr Val Phe Asp Leu Pro Lys Phe Ser Val Cys Gly Ser Ser Gln Glu 
        35                  40                  45              


Ser Asp Ser Leu Pro Asn Ser Ala His Asp Arg Asp Arg Thr Gln Asp 
    50                  55                  60                  


Phe Pro Glu Ser Asn Arg Leu Lys Leu Leu Gln Asn Ala Gln Pro Pro 
65                  70                  75                  80  


Met Val Thr Asn Thr Ala Arg Thr Cys Pro Thr Phe Ser Ala Pro Val 
                85                  90                  95      


Gly Glu Ser Ala Thr Ala Lys Phe His Val Thr Pro Leu Phe Gly Asn 
            100                 105                 110         


Val Lys Lys Glu Asn His Ser Ser Ala Lys Glu Asn Ile Gly Leu Asn 
        115                 120                 125             


Val Phe Leu Ser Asn Gln Ser Cys Phe Pro Ala Ala Cys Glu Asn Pro 
    130                 135                 140                 


Gln Arg Lys Ser Phe Tyr Gly Ser Gly Thr Ile Asp Ala Leu Ser Asn 
145                 150                 155                 160 


Pro Ile Leu Asn Lys Ala Cys Ser Lys Thr Glu Asp Asn Gly Pro Lys 
                165                 170                 175     


Glu Asp Ser Ser Leu Pro Thr Phe Lys Thr Ala Lys Glu Gln Leu Trp 
            180                 185                 190         


Val Asp Gln Gln Lys Lys Tyr His Gln Pro Gln Arg Ala Ser Gly Ser 
        195                 200                 205             


Ser Tyr Gly Gly Val Lys Lys Ser Leu Gly Ala Ser Arg Ser Arg Gly 
    210                 215                 220                 


Ile Leu Gly Lys Phe Val Pro Pro Ile Pro Lys Gln Asp Gly Gly Glu 
225                 230                 235                 240 


Gln Asn Gly Gly Met Gln Cys Lys Pro Tyr Gly Ala Gly Pro Thr Glu 
                245                 250                 255     


Pro Ala His Pro Val Asp Glu Arg Leu Lys Asn Leu Glu Pro Lys Met 
            260                 265                 270         


Ile Glu Leu Ile Met Asn Glu Ile Met Asp His Gly Pro Pro Val Asn 
        275                 280                 285             


Trp Glu Asp Ile Ala Gly Val Glu Phe Ala Lys Ala Thr Ile Lys Glu 
    290                 295                 300                 


Ile Val Val Trp Pro Met Leu Arg Pro Asp Ile Phe Thr Gly Leu Arg 
305                 310                 315                 320 


Gly Pro Pro Lys Gly Ile Leu Leu Phe Gly Pro Pro Gly Thr Gly Lys 
                325                 330                 335     


Thr Leu Ile Gly Lys Cys Ile Ala Ser Gln Ser Gly Ala Thr Phe Phe 
            340                 345                 350         


Ser Ile Ser Ala Ser Ser Leu Thr Ser Lys Trp Val Gly Glu Gly Glu 
        355                 360                 365             


Lys Met Val Arg Ala Leu Phe Ala Val Ala Arg Cys Gln Gln Pro Ala 
    370                 375                 380                 


Val Ile Phe Ile Asp Glu Ile Asp Ser Leu Leu Ser Gln Arg Gly Asp 
385                 390                 395                 400 


Gly Glu His Glu Ser Ser Arg Arg Ile Lys Thr Glu Phe Leu Val Gln 
                405                 410                 415     


Leu Asp Gly Ala Thr Thr Ser Ser Glu Asp Arg Ile Leu Val Val Gly 
            420                 425                 430         


Ala Thr Asn Arg Pro Gln Glu Ile Asp Glu Ala Ala Arg Arg Arg Leu 
        435                 440                 445             


Val Lys Arg Leu Tyr Ile Pro Leu Pro Glu Ala Ser Ala Arg Lys Gln 
    450                 455                 460                 


Ile Val Ile Asn Leu Met Ser Lys Glu Gln Cys Cys Leu Ser Glu Glu 
465                 470                 475                 480 


Glu Ile Glu Gln Ile Val Gln Gln Ser Asp Ala Phe Ser Gly Ala Asp 
                485                 490                 495     


Met Thr Gln Leu Cys Arg Glu Ala Ser Leu Gly Pro Ile Arg Ser Leu 
            500                 505                 510         


Gln Thr Ala Asp Ile Ala Thr Ile Thr Pro Asp Gln Val Arg Pro Ile 
        515                 520                 525             


Ala Tyr Ile Asp Phe Glu Asn Ala Phe Arg Thr Val Arg Pro Ser Val 
    530                 535                 540                 


Ser Pro Lys Asp Leu Glu Leu Tyr Glu Asn Trp Asn Lys Thr Phe Gly 
545                 550                 555                 560 


Cys Gly Lys 
            


<210>  32
<211>  697
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Arg Leu Val Ala Val Cys Arg Asp Gly Glu Glu Glu Phe Pro 
1               5                   10                  15      


Phe Glu Arg Arg Gln Ile Pro Leu Tyr Ile Asp Asp Thr Leu Thr Met 
            20                  25                  30          


Val Met Glu Phe Pro Asp Asn Val Leu Asn Leu Asp Gly His Gln Asn 
        35                  40                  45              


Asn Gly Ala Gln Leu Lys Gln Phe Ile Gln Arg His Gly Met Leu Lys 
    50                  55                  60                  


Gln Gln Asp Leu Ser Ile Ala Met Val Val Thr Ser Arg Glu Val Leu 
65                  70                  75                  80  


Ser Ala Leu Ser Gln Leu Val Pro Cys Val Gly Cys Arg Arg Ser Val 
                85                  90                  95      


Glu Arg Leu Phe Ser Gln Leu Val Glu Ser Gly Asn Pro Ala Leu Glu 
            100                 105                 110         


Pro Leu Thr Val Gly Pro Lys Gly Val Leu Ser Val Thr Arg Ser Cys 
        115                 120                 125             


Met Thr Asp Ala Lys Lys Leu Tyr Thr Leu Phe Tyr Val His Gly Ser 
    130                 135                 140                 


Lys Leu Asn Asp Met Ile Asp Ala Ile Pro Lys Ser Lys Lys Asn Lys 
145                 150                 155                 160 


Arg Cys Gln Leu His Ser Leu Asp Thr His Lys Pro Lys Pro Leu Gly 
                165                 170                 175     


Gly Cys Trp Met Asp Val Trp Glu Leu Met Ser Gln Glu Cys Arg Asp 
            180                 185                 190         


Glu Val Val Leu Ile Asp Ser Ser Cys Leu Leu Glu Thr Leu Glu Thr 
        195                 200                 205             


Tyr Leu Arg Lys His Arg Phe Cys Thr Asp Cys Lys Asn Lys Val Leu 
    210                 215                 220                 


Arg Ala Tyr Asn Ile Leu Ile Gly Glu Leu Asp Cys Ser Lys Glu Lys 
225                 230                 235                 240 


Gly Tyr Cys Ala Ala Leu Tyr Glu Gly Leu Arg Cys Cys Pro His Glu 
                245                 250                 255     


Arg His Ile His Val Cys Cys Glu Thr Asp Phe Ile Ala His Leu Leu 
            260                 265                 270         


Gly Arg Ala Glu Pro Glu Phe Ala Gly Gly Arg Arg Glu Arg His Ala 
        275                 280                 285             


Lys Thr Ile Asp Ile Ala Gln Glu Glu Val Leu Thr Cys Leu Gly Ile 
    290                 295                 300                 


His Leu Tyr Glu Arg Leu His Arg Ile Trp Gln Lys Leu Arg Ala Glu 
305                 310                 315                 320 


Glu Gln Thr Trp Gln Met Leu Phe Tyr Leu Gly Val Asp Ala Leu Arg 
                325                 330                 335     


Lys Ser Phe Glu Met Thr Val Glu Lys Val Gln Gly Ile Ser Arg Leu 
            340                 345                 350         


Glu Gln Leu Cys Glu Glu Phe Ser Glu Glu Glu Arg Val Arg Glu Leu 
        355                 360                 365             


Lys Gln Glu Lys Lys Arg Gln Lys Arg Lys Asn Arg Arg Lys Asn Lys 
    370                 375                 380                 


Cys Val Cys Asp Ile Pro Thr Pro Leu Gln Thr Ala Asp Glu Lys Glu 
385                 390                 395                 400 


Val Ser Gln Glu Lys Glu Thr Asp Phe Ile Glu Asn Ser Ser Cys Lys 
                405                 410                 415     


Ala Cys Gly Ser Thr Glu Asp Gly Asn Thr Cys Val Glu Val Ile Val 
            420                 425                 430         


Thr Asn Glu Asn Thr Ser Cys Thr Cys Pro Ser Ser Gly Asn Leu Leu 
        435                 440                 445             


Gly Ser Pro Lys Ile Lys Lys Gly Leu Ser Pro His Cys Asn Gly Ser 
    450                 455                 460                 


Asp Cys Gly Tyr Ser Ser Ser Met Glu Gly Ser Glu Thr Gly Ser Arg 
465                 470                 475                 480 


Glu Gly Ser Asp Val Ala Cys Thr Glu Gly Ile Cys Asn His Asp Glu 
                485                 490                 495     


His Gly Asp Asp Ser Cys Val His His Cys Glu Asp Lys Glu Asp Asp 
            500                 505                 510         


Gly Asp Ser Cys Val Glu Cys Trp Ala Asn Ser Glu Glu Asn Asp Thr 
        515                 520                 525             


Lys Gly Lys Asn Lys Lys Lys Lys Lys Lys Ser Lys Ile Leu Lys Cys 
    530                 535                 540                 


Asp Glu His Ile Gln Lys Leu Gly Ser Cys Ile Thr Asp Pro Gly Asn 
545                 550                 555                 560 


Arg Glu Thr Ser Gly Asn Thr Met His Thr Val Phe His Arg Asp Lys 
                565                 570                 575     


Thr Lys Asp Thr His Pro Glu Ser Cys Cys Ser Ser Glu Lys Gly Gly 
            580                 585                 590         


Gln Pro Leu Pro Trp Phe Glu His Arg Lys Asn Val Pro Gln Phe Ala 
        595                 600                 605             


Glu Pro Thr Glu Thr Leu Phe Gly Pro Asp Ser Gly Lys Gly Ala Lys 
    610                 615                 620                 


Ser Leu Val Glu Leu Leu Asp Glu Ser Glu Cys Thr Ser Asp Glu Glu 
625                 630                 635                 640 


Ile Phe Ile Ser Gln Asp Glu Ile Gln Ser Phe Met Ala Asn Asn Gln 
                645                 650                 655     


Ser Phe Tyr Ser Asn Arg Glu Gln Tyr Arg Gln His Leu Lys Glu Lys 
            660                 665                 670         


Phe Asn Lys Tyr Cys Arg Leu Asn Asp His Lys Arg Pro Ile Cys Ser 
        675                 680                 685             


Gly Trp Leu Thr Thr Ala Gly Ala Asn 
    690                 695         


<210>  33
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Arg Leu Val Ala Val Cys Arg Asp Gly Glu Glu Glu Phe Pro 
1               5                   10                  15      


Phe Glu Arg Arg Gln Ile Pro Leu Tyr Ile Asp Asp Thr Leu Thr Met 
            20                  25                  30          


Val Met Glu Phe Pro Asp Asn Val Leu Asn Leu Asp Gly His Gln Asn 
        35                  40                  45              


Asn Gly Ala Gln Leu Lys Gln Phe Ile Gln Arg His Gly Met Leu Lys 
    50                  55                  60                  


Gln Gln Asp Leu Ser Ile Ala Met Val Val Thr Ser Arg Glu Val Leu 
65                  70                  75                  80  


Ser Ala Leu Ser Gln Leu Val Pro Cys Val Gly Cys Arg Arg Ser Val 
                85                  90                  95      


Glu Arg Leu Phe Ser Gln Leu Val Glu Ser Gly Asn Pro Ala Leu Glu 
            100                 105                 110         


Pro Leu Thr Val Gly Pro Lys Gly Val Leu Ser Val Thr Arg Ser Cys 
        115                 120                 125             


Met Thr Asp Ala Lys Lys Leu Tyr Thr Leu Phe Tyr Val His Gly Ser 
    130                 135                 140                 


Lys Leu Asn Asp Met Ile Asp Ala Ile Pro Lys Ser Lys Lys Asn Lys 
145                 150                 155                 160 


Arg Cys Gln Leu His Ser Leu Asp Thr His Lys Pro Lys Pro Leu Gly 
                165                 170                 175     


Gly Cys Trp Met Asp Val Trp Glu Leu Met Ser Gln Glu Cys Arg Asp 
            180                 185                 190         


Glu Val Val Leu Ile Asp Ser Ser Cys Leu Leu Glu Thr Leu Glu Thr 
        195                 200                 205             


Tyr Leu Arg Lys His Arg Phe Cys Thr Asp Cys Lys Asn Lys Val Leu 
    210                 215                 220                 


Arg Ala Tyr Asn Ile Leu Ile Gly Glu Leu Asp Cys Ser Lys Glu Lys 
225                 230                 235                 240 


Gly Tyr Cys Ala Ala Leu Tyr Glu Gly Leu Arg Cys Cys Pro His Glu 
                245                 250                 255     


Arg His Ile His Val Cys Cys Glu Thr Asp Phe Ile Ala His Leu Leu 
            260                 265                 270         


Gly Arg Ala Glu Pro Glu Phe Ala Gly Gly Tyr Glu Tyr Val Ile Cys 
        275                 280                 285             


<210>  34
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Arg Leu Val Ala Val Cys Arg Asp Gly Glu Glu Glu Phe Pro 
1               5                   10                  15      


Phe Glu Arg Arg Gln Ile Pro Leu Tyr Ile Asp Asp Thr Leu Thr Met 
            20                  25                  30          


Val Met Glu Phe Pro Asp Asn Val Leu Asn Leu Asp Gly His Gln Asn 
        35                  40                  45              


Asn Gly Ala Gln Leu Lys Gln Phe Ile Gln Arg His Gly Met Leu Lys 
    50                  55                  60                  


Gln Gln Asp Leu Ser Ile Ala Met Val Val Thr Ser Arg Glu Val Leu 
65                  70                  75                  80  


Ser Ala Leu Ser Gln Leu Val Pro Cys Val Gly Cys Arg Arg Ser Val 
                85                  90                  95      


Glu Arg Leu Phe Ser Gln Leu Val Glu Ser Gly Asn Pro Ala Leu Glu 
            100                 105                 110         


Pro Leu Thr Val Gly Pro Lys Gly Val Leu Ser Val Thr Arg Ser Cys 
        115                 120                 125             


Met Thr Asp Ala Lys Lys Leu Tyr Thr Leu Phe Tyr Val His Gly Ser 
    130                 135                 140                 


Lys Leu Asn Asp Met Ile Asp Ala Ile Pro Lys Ser Lys Lys Asn Lys 
145                 150                 155                 160 


Arg Cys Gln Leu His Ser Leu Asp Thr His Lys Pro Lys Pro Leu Gly 
                165                 170                 175     


Gly Cys Trp Met Asp Val Trp Glu Leu Met Ser Gln Glu Cys Arg Asp 
            180                 185                 190         


Glu Val Val Leu Ile Asp Ser Ser Cys Leu Leu Glu Thr Leu Glu Thr 
        195                 200                 205             


Tyr Leu Arg Lys His Arg Phe Cys Thr Asp Cys Lys Asn Lys Val Leu 
    210                 215                 220                 


Arg Ala Tyr Asn Ile Leu Ile Gly Glu Leu Asp Cys Ser Lys Glu Lys 
225                 230                 235                 240 


Gly Tyr Cys Ala Ala Leu Tyr Glu Gly Leu Arg Cys Cys Pro His Glu 
                245                 250                 255     


Arg His Ile His Val Cys Cys Glu Thr Asp Phe Ile Ala His Leu Leu 
            260                 265                 270         


Gly Arg Ala Glu Pro Glu Phe Ala Gly Gly Arg Arg Glu Arg His Ala 
        275                 280                 285             


Lys Thr Ile Asp Ile Ala Gln Glu Glu Val Leu Thr Cys Leu Gly Ile 
    290                 295                 300                 


His Leu Tyr Glu Arg Leu His Arg Ile Trp Gln Lys Leu Arg Ala Glu 
305                 310                 315                 320 


Glu Gln Thr Trp Gln Met Leu Phe Tyr Leu Gly Val Asp Ala Leu Arg 
                325                 330                 335     


Lys Ser Phe Glu Met Thr Val Glu Lys Val Gln Gly Ile Ser Arg Leu 
            340                 345                 350         


Glu Gln Leu Cys Glu Glu Phe Ser Glu Glu Glu Arg Val Arg Glu Leu 
        355                 360                 365             


Lys Gln Glu Lys Lys Arg Gln Lys Arg Lys Asn Arg Arg Lys Asn Lys 
    370                 375                 380                 


Cys Val Cys Asp Ile Pro Thr Pro Leu Gln Thr Ala Asp Glu Lys Glu 
385                 390                 395                 400 


Val Ser Gln Glu Lys Glu Thr Asp Phe Ile Glu Asn Ser Ser Cys Lys 
                405                 410                 415     


Ala Cys Gly Ser Thr Glu Asp Gly Asn Thr Cys Val Glu Val Ile Val 
            420                 425                 430         


Thr Asn Glu Asn Thr Ser Cys Thr Cys Pro Ser Ser Gly Asn Leu Leu 
        435                 440                 445             


Gly Ser Pro Lys Ile Lys Lys Gly Lys 
    450                 455         


<210>  35
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Gly Cys Thr Leu Ser Ala Glu Glu Arg Ala Ala Leu Glu Arg Ser 
1               5                   10                  15      


Lys Ala Ile Glu Lys Asn Leu Lys Glu Asp Gly Ile Ser Ala Ala Lys 
            20                  25                  30          


Asp Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Phe Ser Gly Glu 
    50                  55                  60                  


Asp Val Lys Gln Tyr Lys Pro Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Leu Ala Ala Ile Val Arg Ala Met Asp Thr Leu Gly Ile Glu Tyr Gly 
                85                  90                  95      


Asp Lys Glu Arg Lys Ala Asp Ala Lys Met Val Cys Asp Val Val Ser 
            100                 105                 110         


Arg Met Glu Asp Thr Glu Pro Phe Ser Ala Glu Leu Leu Ser Ala Met 
        115                 120                 125             


Met Arg Leu Trp Gly Asp Ser Gly Ile Gln Glu Cys Phe Asn Arg Ser 
    130                 135                 140                 


Arg Glu Tyr Gln Leu Asn Asp Ser Ala Lys Tyr Tyr Leu Asp Ser Leu 
145                 150                 155                 160 


Asp Arg Ile Gly Ala Ala Asp Tyr Gln Pro Thr Glu Gln Asp Ile Leu 
                165                 170                 175     


Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe 
            180                 185                 190         


Lys Asn Leu His Phe Arg Leu Phe Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Asp Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Ala Leu Ser Gly Tyr Asp Gln Val Leu His Glu Asp Glu Thr 
225                 230                 235                 240 


Thr Asn Arg Met His Glu Ser Leu Met Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Lys Phe Phe Ile Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Leu Phe Gly Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Thr Gly Pro Asn Thr Tyr Glu Asp Ala Ala Ala Tyr Ile 
    290                 295                 300                 


Gln Ala Gln Phe Glu Ser Lys Asn Arg Ser Pro Asn Lys Glu Ile Tyr 
305                 310                 315                 320 


Cys His Met Thr Cys Ala Thr Asp Thr Asn Asn Ile Gln Val Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Ile Ile Ile Ala Asn Asn Leu Arg Gly Cys Gly 
            340                 345                 350         


Leu Tyr 
        


<210>  36
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Cys Thr Leu Ser Ala Glu Glu Arg Ala Ala Leu Glu Arg Ser 
1               5                   10                  15      


Lys Ala Ile Glu Lys Asn Leu Lys Glu Asp Gly Ile Ser Ala Ala Lys 
            20                  25                  30          


Asp Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Phe Ser Gly Glu 
    50                  55                  60                  


Asp Val Lys Gln Tyr Lys Pro Val Val Tyr Ser Asn Thr Ile Gln Ser 
65                  70                  75                  80  


Leu Ala Ala Ile Val Arg Ala Met Asp Thr Leu Gly Ile Glu Tyr Gly 
                85                  90                  95      


Asp Lys Glu Arg Lys Ala Asp Ala Lys Met Val Cys Asp Val Val Ser 
            100                 105                 110         


Arg Met Glu Asp Thr Glu Pro Phe Ser Ala Glu Leu Leu Ser Ala Met 
        115                 120                 125             


Met Arg Leu Trp Gly Asp Ser Gly Ile Gln Glu Cys Phe Asn Arg Ser 
    130                 135                 140                 


Arg Glu Tyr Gln Leu Asn Asp Ser Ala Lys Tyr Tyr Leu Asp Ser Leu 
145                 150                 155                 160 


Asp Arg Ile Gly Ala Ala Asp Tyr Gln Pro Thr Glu Gln Asp Ile Leu 
                165                 170                 175     


Arg Thr Arg Val Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe 
            180                 185                 190         


Lys Asn Leu His Phe Arg Leu Phe Asp Val Gly Gly Gln Arg Ser Glu 
        195                 200                 205             


Arg Lys Lys Trp Ile His Cys Phe Glu Asp Val Thr Ala Ile Ile Phe 
    210                 215                 220                 


Cys Val Ala Leu Ser Gly Tyr Asp Gln Val Leu His Glu Asp Glu Thr 
225                 230                 235                 240 


Thr Asn Arg Met His Glu Ser Leu Lys Leu Phe Asp Ser Ile Cys Asn 
                245                 250                 255     


Asn Lys Trp Phe Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys 
            260                 265                 270         


Asp Ile Phe Glu Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Phe 
        275                 280                 285             


Pro Glu Tyr Thr Gly Pro Ser Ala Phe Thr Glu Ala Val Ala Tyr Ile 
    290                 295                 300                 


Gln Ala Gln Tyr Glu Ser Lys Asn Lys Ser Ala His Lys Glu Ile Tyr 
305                 310                 315                 320 


Thr His Val Thr Cys Ala Thr Asp Thr Asn Asn Ile Gln Phe Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Val Ile Ile Ala Lys Asn Leu Arg Gly Cys Gly 
            340                 345                 350         


Leu Tyr 
        


<210>  37
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Gly Gly Lys Ala Gly Lys Asp Ser Gly Lys Ala Lys Thr Lys 
1               5                   10                  15      


Ala Val Ser Arg Ser Gln Arg Ala Gly Leu Gln Phe Pro Val Gly Arg 
            20                  25                  30          


Ile His Arg His Leu Lys Ser Arg Thr Thr Ser His Gly Arg Val Gly 
        35                  40                  45              


Ala Thr Ala Ala Val Tyr Ser Ala Ala Ile Leu Glu Tyr Leu Thr Ala 
    50                  55                  60                  


Glu Val Leu Glu Leu Ala Gly Asn Ala Ser Lys Asp Leu Lys Val Lys 
65                  70                  75                  80  


Arg Ile Thr Pro Arg His Leu Gln Leu Ala Ile Arg Gly Asp Glu Glu 
                85                  90                  95      


Leu Asp Ser Leu Ile Lys Ala Thr Ile Ala Gly Gly Gly Val Ile Pro 
            100                 105                 110         


His Ile His Lys Ser Leu Ile Gly Lys Lys Gly Gln Gln Lys Thr Val 
        115                 120                 125             


<210>  38
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp 
1               5                   10                  15      


Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala 
            20                  25                  30          


Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly 
        35                  40                  45              


Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu 
    50                  55                  60                  


Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln 
65                  70                  75                  80  


Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg 
                85                  90                  95      


Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Leu Thr Val Lys 
            100                 105                 110         


Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys His Glu Glu Arg Gln 
        115                 120                 125             


Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu 
    130                 135                 140                 


Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu 
145                 150                 155                 160 


Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser 
                165                 170                 175     


Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly 
            180                 185                 190         


Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala Ala Lys 
        195                 200                 205 


<210>  39
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val 
1               5                   10                  15      


Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro 
            20                  25                  30          


Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu 
        35                  40                  45              


Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile 
    50                  55                  60                  


Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu 
65                  70                  75                  80  


Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser 
                85                  90                  95      


Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr 
            100                 105                 110         


Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val 
        115                 120                 125             


Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala 
    130                 135                 140                 


Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro 
145                 150                 155                 160 


Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala 
                165                 170                 175     


Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu 
            180                 185                 190         


Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met 
        195                 200                 205             


Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu 
    210                 215                 220                 


Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr 
225                 230                 235                 240 


Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr 
                245                 250                 255     


Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro 
            260                 265                 270         


Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly 
        275                 280                 285             


Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys 
305                 310                 315                 320 


Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val 
                325                 330                 335     


Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr 
            340                 345                 350         


Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp 
        355                 360                 365             


Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr 
    370                 375                 380                 


Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val 
385                 390                 395                 400 


Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser 
                405                 410                 415     


Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser 
            420                 425                 430         


Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe 
        435                 440                 445             


Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro 
    450                 455                 460                 


Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu 
465                 470                 475                 480 


His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His 
                485                 490                 495     


Asp Gly Cys Cys Ser Leu 
            500         


<210>  40
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val 
1               5                   10                  15      


Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro 
            20                  25                  30          


Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu 
        35                  40                  45              


Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile 
    50                  55                  60                  


Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu 
65                  70                  75                  80  


Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser 
                85                  90                  95      


Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr 
            100                 105                 110         


Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val 
        115                 120                 125             


Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala 
    130                 135                 140                 


Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro 
145                 150                 155                 160 


Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala 
                165                 170                 175     


Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu 
            180                 185                 190         


Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met 
        195                 200                 205             


Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu 
    210                 215                 220                 


Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr 
225                 230                 235                 240 


Gly Asp Ser Glu Gly Ala Thr Val Gln Val Lys Phe Ser Glu Leu Leu 
                245                 250                 255     


Trp Gly Gly Lys Gly His Arg Arg Leu Phe His His Ser Leu Leu Leu 
            260                 265                 270         


Arg Met Ser Ser Leu Leu Ser Asn Ala Leu Leu Pro Ala Asp Thr Ser 
        275                 280                 285             


<210>  41
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Val Ser Leu Glu Pro Trp Gly Asp Glu Glu Arg Leu Arg 
        35                  40                  45              


Val Gln Phe Leu Ala Gln Gln Ser Leu Ser Leu Ala Pro Val Thr Ala 
    50                  55                  60                  


Ala Thr Ala Arg Thr Ala Leu Ser Gly Leu Ser Gly Ala Asp Gly Arg 
65                  70                  75                  80  


Arg Glu Glu Arg Gly Arg Gly Lys Ser Trp Val Cys Leu Ser Leu Gly 
                85                  90                  95      


Gly Ser Gly Asn Thr Glu Pro Gln Lys Lys Gly Leu Ser Cys Arg Leu 
            100                 105                 110         


Trp Asp Ser Asp Ile Leu Cys Leu Pro Gly Asp Ile Val Pro Ala Pro 
        115                 120                 125             


Gly Pro Val Leu Ala Pro Thr His Leu Gln Thr Glu Leu Val Leu Arg 
    130                 135                 140                 


Cys Gln Lys Glu Thr Asp Cys Asp Leu Cys Leu Arg Val Ala Val His 
145                 150                 155                 160 


Leu Ala Val His Gly His Trp Glu Glu Pro Glu Asp Glu Glu Lys Phe 
                165                 170                 175     


Gly Gly Ala Ala Asp Ser Gly Val Glu Glu Pro Arg Asn Ala Ser Leu 
            180                 185                 190         


Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr Pro Thr Ala Arg Cys 
        195                 200                 205             


Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu Val Gln Phe Gly Gln 
    210                 215                 220                 


Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu Ala Ala Leu Gly Ser 
225                 230                 235                 240 


Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg Tyr Glu Lys Glu Leu 
                245                 250                 255     


Asn His Thr Gln Gln Leu Pro Asp Cys Arg Gly Leu Glu Val Trp Asn 
            260                 265                 270         


Ser Ile Pro Ser Cys Trp Ala Leu Pro Trp Leu Asn Val Ser Ala Asp 
        275                 280                 285             


Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His Phe 
    290                 295                 300                 


Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro Arg 
305                 310                 315                 320 


Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His Thr 
                325                 330                 335     


Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro Asp 
            340                 345                 350         


Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala His 
        355                 360                 365             


Gln Asn Leu Trp Gln Ala Ala Arg Leu Gln Leu Leu Thr Leu Gln Ser 
    370                 375                 380                 


Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys 
385                 390                 395                 400 


Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro Leu 
                405                 410                 415     


Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu Leu 
            420                 425                 430         


Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys Leu 
        435                 440                 445             


Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp 
    450                 455                 460                 


Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu 
465                 470                 475                 480 


Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser 
                485                 490                 495     


Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser 
            500                 505                 510         


Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala 
        515                 520                 525             


Cys Pro Met Asp Lys Tyr Ile His Lys Arg Trp Ala Leu Val Trp Leu 
    530                 535                 540                 


Ala Cys Leu Leu Phe Ala Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys 
545                 550                 555                 560 


Lys Asp His Ala Lys Gly Trp Leu Arg Leu Leu Lys Gln Asp Val Arg 
                565                 570                 575     


Ser Gly Ala Ala Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala 
            580                 585                 590         


Asp Asp Ser Gly Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu 
        595                 600                 605             


Cys Gln Leu Pro Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu 
    610                 615                 620                 


Leu Ser Ala Gln Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln 
625                 630                 635                 640 


Thr Leu Gln Glu Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala 
                645                 650                 655     


Val Ala Leu Cys Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly 
            660                 665                 670         


Ala His Gly Pro His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu 
        675                 680                 685             


Pro Asp Phe Leu Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys 
    690                 695                 700                 


Phe Asp Arg Leu Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr 
705                 710                 715                 720 


Val Pro Val Phe Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala 
                725                 730                 735     


Leu Gln Gln Pro Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala 
            740                 745                 750         


Glu Gln Val Ser Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His 
        755                 760                 765             


Pro Pro Gly Thr Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly 
    770                 775                 780                 


Pro Gly Ala Gly Asp Gly Thr 
785                 790     


<210>  42
<211>  720
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala 
        195                 200                 205             


Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val 
    210                 215                 220                 


Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn 
225                 230                 235                 240 


Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly 
                245                 250                 255     


Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys 
            260                 265                 270         


Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys 
        275                 280                 285             


Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala 
    290                 295                 300                 


Arg Leu Gln Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys 
305                 310                 315                 320 


Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp 
                325                 330                 335     


Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val 
            340                 345                 350         


Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys 
        355                 360                 365             


Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp 
    370                 375                 380                 


Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr 
385                 390                 395                 400 


Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly 
                405                 410                 415     


Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly 
            420                 425                 430         


Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp 
        435                 440                 445             


Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile 
    450                 455                 460                 


His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala 
465                 470                 475                 480 


Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly Trp 
                485                 490                 495     


Leu Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Ala Ala Ala Arg Gly 
            500                 505                 510         


Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu Arg 
        515                 520                 525             


Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg Val 
    530                 535                 540                 


Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro Val 
545                 550                 555                 560 


Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly Val 
                565                 570                 575     


Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu Trp 
            580                 585                 590         


Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp Ala 
        595                 600                 605             


Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly Arg 
    610                 615                 620                 


Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His Pro 
625                 630                 635                 640 


Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu Pro 
                645                 650                 655     


Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala Pro 
            660                 665                 670         


Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala Leu 
        675                 680                 685             


Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala Pro 
    690                 695                 700                 


Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly Thr 
705                 710                 715                 720 


<210>  43
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu 
        195                 200                 205             


Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp 
    210                 215                 220                 


Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr 
225                 230                 235                 240 


Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu 
                245                 250                 255     


Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile 
            260                 265                 270         


Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala 
        275                 280                 285             


Ala Arg Leu Gln Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro 
    290                 295                 300                 


Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly 
305                 310                 315                 320 


Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr 
                325                 330                 335     


Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu 
            340                 345                 350         


Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu 
        355                 360                 365             


Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu 
    370                 375                 380                 


Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser 
385                 390                 395                 400 


Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu 
                405                 410                 415     


Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu 
            420                 425                 430         


Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr 
        435                 440                 445             


Ile His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala 
    450                 455                 460                 


Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly 
465                 470                 475                 480 


Trp Leu Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Ala Ala Ala Arg 
                485                 490                 495     


Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu 
            500                 505                 510         


Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg 
        515                 520                 525             


Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro 
    530                 535                 540                 


Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly 
545                 550                 555                 560 


Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu 
                565                 570                 575     


Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp 
            580                 585                 590         


Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly 
        595                 600                 605             


Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His 
    610                 615                 620                 


Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu 
625                 630                 635                 640 


Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala 
                645                 650                 655     


Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala 
            660                 665                 670         


Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala 
        675                 680                 685             


Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly 
    690                 695                 700                 


Thr 
705 


<210>  44
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu 
        195                 200                 205             


Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp 
    210                 215                 220                 


Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr 
225                 230                 235                 240 


Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu 
                245                 250                 255     


Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile 
            260                 265                 270         


Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala 
        275                 280                 285             


Ala Arg Leu Gln Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro 
    290                 295                 300                 


Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly 
305                 310                 315                 320 


Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr 
                325                 330                 335     


Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu 
            340                 345                 350         


Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu 
        355                 360                 365             


Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu 
    370                 375                 380                 


Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser 
385                 390                 395                 400 


Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu 
                405                 410                 415     


Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu 
            420                 425                 430         


Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr 
        435                 440                 445             


Ile His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala 
    450                 455                 460                 


Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly 
465                 470                 475                 480 


Trp Leu Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Gly Glu Trp Glu 
                485                 490                 495     


Gln Ala Leu Gly Gly Gly Pro Pro Pro Gly Ser Gln Ala Cys Ala Ser 
            500                 505                 510         


Ser Pro Leu Pro Ser Pro Ser Val Phe Ser Gly Ser Gly Arg Gln Gly 
        515                 520                 525             


Pro Arg Gly Ser Ala Pro Leu Leu Ser Arg 
    530                 535             


<210>  45
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala 
        195                 200                 205             


Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val 
    210                 215                 220                 


Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn 
225                 230                 235                 240 


Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly 
                245                 250                 255     


Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys 
            260                 265                 270         


Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys 
        275                 280                 285             


Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala 
    290                 295                 300                 


Arg Leu Gln Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys 
305                 310                 315                 320 


Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp 
                325                 330                 335     


Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val 
            340                 345                 350         


Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys 
        355                 360                 365             


Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp 
    370                 375                 380                 


Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr 
385                 390                 395                 400 


Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly 
                405                 410                 415     


Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly 
            420                 425                 430         


Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp 
        435                 440                 445             


Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile 
    450                 455                 460                 


His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala 
465                 470                 475                 480 


Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Ala Ala 
                485                 490                 495     


Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly 
            500                 505                 510         


Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro 
        515                 520                 525             


Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln 
    530                 535                 540                 


Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu 
545                 550                 555                 560 


Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys 
                565                 570                 575     


Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro 
            580                 585                 590         


His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu 
        595                 600                 605             


Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu 
    610                 615                 620                 


Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe 
625                 630                 635                 640 


Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro 
                645                 650                 655     


Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser 
            660                 665                 670         


Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr 
        675                 680                 685             


Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly 
    690                 695                 700                 


Asp Gly Thr 
705         


<210>  46
<211>  688
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu 
        195                 200                 205             


Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp 
    210                 215                 220                 


Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr 
225                 230                 235                 240 


Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu 
                245                 250                 255     


Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile 
            260                 265                 270         


Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala 
        275                 280                 285             


Ala Arg Leu Gln Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro 
    290                 295                 300                 


Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly 
305                 310                 315                 320 


Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr 
                325                 330                 335     


Val Asp Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp 
            340                 345                 350         


Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr 
        355                 360                 365             


Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly 
    370                 375                 380                 


Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly 
385                 390                 395                 400 


Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp 
                405                 410                 415     


Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile 
            420                 425                 430         


His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala 
        435                 440                 445             


Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly Trp 
    450                 455                 460                 


Leu Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Ala Ala Ala Arg Gly 
465                 470                 475                 480 


Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu Arg 
                485                 490                 495     


Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg Val 
            500                 505                 510         


Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro Val 
        515                 520                 525             


Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly Val 
    530                 535                 540                 


Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu Trp 
545                 550                 555                 560 


Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp Ala 
                565                 570                 575     


Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly Arg 
            580                 585                 590         


Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His Pro 
        595                 600                 605             


Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu Pro 
    610                 615                 620                 


Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala Pro 
625                 630                 635                 640 


Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala Leu 
                645                 650                 655     


Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala Pro 
            660                 665                 670         


Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly Thr 
        675                 680                 685             


<210>  47
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala 
        195                 200                 205             


Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val 
    210                 215                 220                 


Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn 
225                 230                 235                 240 


Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly 
                245                 250                 255     


Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys 
            260                 265                 270         


Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys 
        275                 280                 285             


Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala 
    290                 295                 300                 


Arg Leu Gln Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys 
305                 310                 315                 320 


Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp 
                325                 330                 335     


Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val 
            340                 345                 350         


Asp Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp Ala 
        355                 360                 365             


Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr Arg 
    370                 375                 380                 


Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly Cys 
385                 390                 395                 400 


Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly Glu 
                405                 410                 415     


Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp Asp 
            420                 425                 430         


Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile His 
        435                 440                 445             


Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala Ala 
    450                 455                 460                 


Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Ala Ala Ala 
465                 470                 475                 480 


Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe 
                485                 490                 495     


Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu 
            500                 505                 510         


Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly 
        515                 520                 525             


Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly 
    530                 535                 540                 


Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser 
545                 550                 555                 560 


Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His 
                565                 570                 575     


Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln 
            580                 585                 590         


Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu 
        595                 600                 605             


His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr 
    610                 615                 620                 


Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg 
625                 630                 635                 640 


Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg 
                645                 650                 655     


Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro 
            660                 665                 670         


Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp 
        675                 680                 685             


Gly Thr 
    690 


<210>  48
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu 
        195                 200                 205             


Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp 
    210                 215                 220                 


Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr 
225                 230                 235                 240 


Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu 
                245                 250                 255     


Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile 
            260                 265                 270         


Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala 
        275                 280                 285             


Ala Arg Leu Gln Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro 
    290                 295                 300                 


Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly 
305                 310                 315                 320 


Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr 
                325                 330                 335     


Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu 
            340                 345                 350         


Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu 
        355                 360                 365             


Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu 
    370                 375                 380                 


Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser 
385                 390                 395                 400 


Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu 
                405                 410                 415     


Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu 
            420                 425                 430         


Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr 
        435                 440                 445             


Ile His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala 
    450                 455                 460                 


Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Ala 
465                 470                 475                 480 


Ala Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser 
                485                 490                 495     


Gly Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu 
            500                 505                 510         


Pro Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala 
        515                 520                 525             


Gln Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln 
    530                 535                 540                 


Glu Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu 
545                 550                 555                 560 


Cys Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly 
                565                 570                 575     


Pro His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe 
            580                 585                 590         


Leu Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg 
        595                 600                 605             


Leu Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val 
    610                 615                 620                 


Phe Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln 
625                 630                 635                 640 


Pro Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val 
                645                 650                 655     


Ser Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly 
            660                 665                 670         


Thr Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala 
        675                 680                 685             


Gly Asp Gly Thr 
    690         


<210>  49
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Arg Gly Asp Arg Gly Arg Gly Arg Gly Gly Arg Phe Gly Ser Arg 
1               5                   10                  15      


Gly Gly Pro Gly Gly Gly Phe Arg Pro Phe Val Pro His Ile Pro Phe 
            20                  25                  30          


Asp Phe Tyr Leu Cys Glu Met Ala Phe Pro Arg Val Lys Pro Ala Pro 
        35                  40                  45              


Asp Glu Thr Ser Phe Ser Glu Ala Leu Leu Lys Arg Asn Gln Asp Leu 
    50                  55                  60                  


Ala Pro Asn Ser Ala Glu Gln Ala Ser Ile Leu Ser Leu Val Thr Lys 
65                  70                  75                  80  


Ile Asn Asn Val Ile Asp Asn Leu Ile Val Ala Pro Gly Thr Phe Glu 
                85                  90                  95      


Val Gln Ile Glu Glu Val Arg Gln Val Gly Ser Tyr Lys Lys Gly Thr 
            100                 105                 110         


Met Thr Thr Gly His Asn Val Ala Asp Leu Val Val Ile Leu Lys Ile 
        115                 120                 125             


Leu Pro Thr Leu Glu Ala Val Ala Ala Leu Gly Asn Lys Val Val Glu 
    130                 135                 140                 


Ser Leu Arg Ala Gln Asp Pro Ser Glu Val Leu Thr Met Leu Thr Asn 
145                 150                 155                 160 


Glu Thr Gly Phe Glu Ile Ser Ser Ser Asp Ala Thr Val Lys Ile Leu 
                165                 170                 175     


Ile Thr Thr Val Pro Pro Asn Leu Arg Lys Leu Asp Pro Glu Leu His 
            180                 185                 190         


Leu Asp Ile Lys Val Leu Gln Ser Ala Leu Ala Ala Ile Arg His Ala 
        195                 200                 205             


Arg Trp Phe Glu Glu Asn Ala Ser Gln Ser Thr Val Lys Val Leu Ile 
    210                 215                 220                 


Arg Leu Leu Lys Asp Leu Arg Ile Arg Phe Pro Gly Phe Glu Pro Leu 
225                 230                 235                 240 


Thr Pro Trp Ile Leu Asp Leu Leu Gly His Tyr Ala Val Met Asn Asn 
                245                 250                 255     


Pro Thr Arg Gln Pro Leu Ala Leu Asn Val Ala Tyr Arg Arg Cys Leu 
            260                 265                 270         


Gln Ile Leu Ala Ala Gly Leu Phe Leu Pro Gly Ser Val Gly Ile Thr 
        275                 280                 285             


Asp Pro Cys Glu Ser Gly Asn Phe Arg Val His Thr Val Met Thr Leu 
    290                 295                 300                 


Glu Gln Gln Asp Met Val Cys Tyr Thr Ala Gln Thr Leu Val Arg Ile 
305                 310                 315                 320 


Leu Ser His Gly Gly Phe Arg Lys Ile Leu Gly Gln Glu Gly Asp Ala 
                325                 330                 335     


Ser Tyr Leu Ala Ser Glu Ile Ser Thr Trp Asp Gly Val Ile Val Thr 
            340                 345                 350         


Pro Ser Glu Lys Ala Tyr Glu Lys Pro Pro Glu Lys Lys Glu Gly Glu 
        355                 360                 365             


Glu Glu Glu Glu Asn Thr Glu Glu Pro Pro Gln Gly Glu Glu Glu Glu 
    370                 375                 380                 


Ser Met Glu Thr Gln Glu 
385                 390 


<210>  50
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Ala Tyr Ser Tyr Arg Pro Gly Pro Gly Ala Gly Pro Gly Pro 
1               5                   10                  15      


Ala Ala Gly Ala Ala Leu Pro Asp Gln Ser Phe Leu Trp Asn Val Phe 
            20                  25                  30          


Gln Arg Val Asp Lys Asp Arg Ser Gly Val Ile Ser Asp Thr Glu Leu 
        35                  40                  45              


Gln Gln Ala Leu Ser Asn Gly Thr Trp Thr Pro Phe Asn Pro Val Thr 
    50                  55                  60                  


Val Arg Ser Ile Ile Ser Met Phe Asp Arg Glu Asn Lys Ala Gly Val 
65                  70                  75                  80  


Asn Phe Ser Glu Phe Thr Gly Val Trp Lys Tyr Ile Thr Asp Trp Gln 
                85                  90                  95      


Asn Val Phe Arg Thr Tyr Asp Arg Asp Asn Ser Gly Met Ile Asp Lys 
            100                 105                 110         


Asn Glu Leu Lys Gln Ala Leu Ser Gly Phe Gly Tyr Arg Leu Ser Asp 
        115                 120                 125             


Gln Phe His Asp Ile Leu Ile Arg Lys Phe Asp Arg Gln Gly Arg Gly 
    130                 135                 140                 


Gln Ile Ala Phe Asp Asp Phe Ile Gln Gly Cys Ile Val Leu Gln Arg 
145                 150                 155                 160 


Leu Thr Asp Ile Phe Arg Arg Tyr Asp Thr Asp Gln Asp Gly Trp Ile 
                165                 170                 175     


Gln Val Ser Tyr Glu Gln Tyr Leu Ser Met Val Phe Ser Ile Val 
            180                 185                 190     


<210>  51
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Ala Tyr Ser Tyr Arg Pro Gly Pro Gly Ala Gly Pro Gly Pro 
1               5                   10                  15      


Ala Ala Gly Ala Ala Leu Pro Asp Gln Ser Phe Leu Trp Asn Val Phe 
            20                  25                  30          


Gln Arg Val Asp Lys Asp Arg Ser Gly Val Ile Ser Asp Thr Glu Leu 
        35                  40                  45              


Gln Gln Ala Leu Ser Asn Gly Thr Trp Thr Pro Phe Asn Pro Val Thr 
    50                  55                  60                  


Val Arg Ser Ile Ile Ser Met Phe Asp Arg Glu Asn Lys Ala Gly Val 
65                  70                  75                  80  


Asn Phe Ser Glu Phe Thr Gly Val Trp Lys Tyr Ile Thr Asp Trp Gln 
                85                  90                  95      


Asn Val Phe Arg Thr Tyr Asp Arg Asp Asn Ser Gly Met Ile Asp Lys 
            100                 105                 110         


Asn Glu Leu Lys Gln Ala Leu Ser Gly Tyr Arg Leu Ser Asp Gln Phe 
        115                 120                 125             


His Asp Ile Leu Ile Arg Lys Phe Asp Arg Gln Gly Arg Gly Gln Ile 
    130                 135                 140                 


Ala Phe Asp Asp Phe Ile Gln Gly Cys Ile Val Leu Gln Arg Leu Thr 
145                 150                 155                 160 


Asp Ile Phe Arg Arg Tyr Asp Thr Asp Gln Asp Gly Trp Ile Gln Val 
                165                 170                 175     


Ser Tyr Glu Gln Tyr Leu Ser Met Val Phe Ser Ile Val 
            180                 185                 


<210>  52
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Ala Tyr Ser Tyr Arg Pro Gly Pro Gly Ala Gly Pro Gly Pro 
1               5                   10                  15      


Ala Ala Gly Ala Ala Leu Pro Asp Gln Ser Phe Leu Trp Asn Val Phe 
            20                  25                  30          


Gln Arg Val Asp Lys Asp Arg Ser Gly Val Ile Ser Asp Thr Glu Leu 
        35                  40                  45              


Gln Gln Ala Leu Ser Asn Gly Thr Trp Thr Pro Phe Asn Pro Val Thr 
    50                  55                  60                  


Val Arg Ser Ile Ile 
65                  


<210>  53
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Arg Ala Ser Ser Phe Leu Ile Val Val Val Phe Leu Ile Ala Gly 
1               5                   10                  15      


Thr Leu Val Leu Glu Ala Ala Val Thr Gly Val Pro Val Lys Gly Gln 
            20                  25                  30          


Asp Thr Val Lys Gly Arg Val Pro Phe Asn Gly Gln Asp Pro Val Lys 
        35                  40                  45              


Gly Gln Val Ser Val Lys Gly Gln Asp Lys Val Lys Ala Gln Glu Pro 
    50                  55                  60                  


Val Lys Gly Pro Val Ser Thr Lys Pro Gly Ser Cys Pro Ile Ile Leu 
65                  70                  75                  80  


Ile Arg Cys Ala Met Leu Asn Pro Pro Asn Arg Cys Leu Lys Asp Thr 
                85                  90                  95      


Asp Cys Pro Gly Ile Lys Lys Cys Cys Glu Gly Ser Cys Gly Met Ala 
            100                 105                 110         


Cys Phe Val Pro Gln 
        115         


<210>  54
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Thr Leu Ser Phe Val Phe Leu Leu Leu Gly Ala Val Ser Trp 
1               5                   10                  15      


Pro Pro Ala Ser Ala Ser Gly Gln Glu Phe Trp Pro Gly Gln Ser Ala 
            20                  25                  30          


Ala Asp Ile Leu Ser Gly Ala Ala Ser Arg Arg Arg Tyr Leu Leu Tyr 
        35                  40                  45              


Asp Val Asn Pro Pro Glu Gly Phe Asn Leu Arg Arg Asp Val Tyr Ile 
    50                  55                  60                  


Arg Ile Ala Ser Leu Leu Lys Thr Leu Leu Lys Thr Glu Glu Trp Val 
65                  70                  75                  80  


Leu Val Leu Pro Pro Trp Gly Arg Leu Tyr His Trp Gln Ser Pro Asp 
                85                  90                  95      


Ile His Gln Val Arg Ile Pro Trp Ser Glu Phe Phe Asp Leu Pro Ser 
            100                 105                 110         


Leu Asn Lys Asn Ile Pro Val Ile Glu Tyr Glu Gln Phe Ile Ala Glu 
        115                 120                 125             


Ser Gly Gly Pro Phe Ile Asp Gln Val Tyr Val Leu Gln Ser Tyr Ala 
    130                 135                 140                 


Glu Gly Trp Lys Glu Gly Thr Trp Glu Glu Lys Val Asp Glu Arg Pro 
145                 150                 155                 160 


Cys Ile Asp Gln Leu Leu Tyr Ser Gln Asp Lys His Glu Tyr Tyr Arg 
                165                 170                 175     


Gly Trp Phe Trp Gly Tyr Glu Glu Thr Arg Gly Leu Asn Val Ser Cys 
            180                 185                 190         


Leu Ser Val Gln Gly Ser Ala Ser Ile Val Ala Pro Leu Leu Leu Arg 
        195                 200                 205             


Asn Thr Ser Ala Arg Ser Val Met Leu Asp Arg Ala Glu Asn Leu Leu 
    210                 215                 220                 


His Asp His Tyr Gly Gly Lys Glu Tyr Trp Asp Thr Arg Arg Ser Met 
225                 230                 235                 240 


Val Phe Ala Arg His Leu Arg Glu Val Gly Asp Glu Phe Arg Ser Arg 
                245                 250                 255     


His Leu Asn Ser Thr Asp Asp Ala Asp Arg Ile Pro Phe Gln Glu Asp 
            260                 265                 270         


Trp Met Lys Met Lys Val Lys Leu Gly Ser Ala Leu Gly Gly Pro Tyr 
        275                 280                 285             


Leu Gly Val His Leu Arg Arg Lys Asp Phe Ile Trp Gly His Arg Gln 
    290                 295                 300                 


Asp Val Pro Ser Leu Glu Gly Ala Val Arg Lys Ile Arg Ser Leu Met 
305                 310                 315                 320 


Lys Thr His Arg Leu Asp Lys Val Phe Val Ala Thr Asp Ala Val Arg 
                325                 330                 335     


Lys Glu Tyr Glu Glu Leu Lys Lys Leu Leu Pro Glu Met Val Arg Phe 
            340                 345                 350         


Glu Pro Thr Trp Glu Glu Leu Glu Leu Tyr Lys Asp Gly Gly Val Ala 
        355                 360                 365             


Ile Ile Asp Gln Trp Ile Cys Ala His Ala Arg Phe Phe Ile Gly Thr 
    370                 375                 380                 


Ser Val Ser Thr Phe Ser Phe Arg Ile His Glu Glu Arg Glu Ile Leu 
385                 390                 395                 400 


Gly Leu Asp Pro Lys Thr Thr Tyr Asn Arg Phe Cys Gly Asp Gln Glu 
                405                 410                 415     


Lys Ala Cys Glu Gln Pro Thr His Trp Lys Ile Thr Tyr 
            420                 425                 


<210>  55
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ala Thr Leu Ser Phe Val Phe Leu Leu Leu Gly Ala Val Ser Trp 
1               5                   10                  15      


Pro Pro Ala Ser Ala Ser Gly Gln Glu Phe Trp Pro Gly Gln Ser Ala 
            20                  25                  30          


Ala Asp Ile Leu Ser Gly Ala Ala Ser Arg Arg Arg Tyr Leu Leu Tyr 
        35                  40                  45              


Asp Val Asn Pro Pro Glu Gly Phe Asn Leu Arg Arg Asp Val Tyr Ile 
    50                  55                  60                  


Arg Ile Ala Ser Leu Leu Lys Thr Leu Leu Lys Thr Glu Glu Trp Val 
65                  70                  75                  80  


Leu Val Leu Pro Pro Trp Gly Arg Leu Tyr His Trp Gln Ser Pro Asp 
                85                  90                  95      


Ile His Gln Val Arg Ile Pro Trp Ser Glu Phe Phe Asp Leu Pro Ser 
            100                 105                 110         


Leu Asn Lys Asn Ile Pro Val Ile Glu Tyr Glu Gln Phe Ile Ala Glu 
        115                 120                 125             


Ser Gly Gly Pro Phe Ile Asp Gln Val Tyr Val Leu Gln Ser Tyr Ala 
    130                 135                 140                 


Glu Gly Trp Lys Glu Gly Thr Trp Glu Glu Lys Val Asp Glu Arg Pro 
145                 150                 155                 160 


Cys Ile Asp Gln Leu Leu Tyr Ser Gln Asp Lys His Glu Tyr Tyr Arg 
                165                 170                 175     


Gly Trp Phe Trp Gly Tyr Glu Glu Thr Arg Gly Leu Asn Val Ser Cys 
            180                 185                 190         


Leu Ser Val Gln Gly Ser Ala Ser Ile Val Ala Pro Leu Leu Leu Arg 
        195                 200                 205             


Asn Thr Ser Ala Arg Ser Val Met Leu Asp Arg Ala Glu Asn Leu Leu 
    210                 215                 220                 


His Asp His Tyr Gly Gly Lys Glu Tyr Trp Asp Thr Arg Arg Ser Met 
225                 230                 235                 240 


Val Phe Ala Arg His Leu Arg Glu Val Gly Asp Glu Phe Arg Ser Arg 
                245                 250                 255     


His Leu Asn Ser Thr Asp Asp Ala Asp Arg Ile Pro Phe Gln Glu Asp 
            260                 265                 270         


Trp Met Lys Met Lys Val Lys Leu Gly Ser Ala Leu Gly Gly Pro Tyr 
        275                 280                 285             


Leu Gly Val His Leu Arg Arg Lys Asp Phe Ile Trp Gly His Arg Gln 
    290                 295                 300                 


Asp Val Pro Ser Leu Glu Gly Ala Val Arg Lys Ile Arg Ser Leu Met 
305                 310                 315                 320 


Lys Thr His Arg Leu Asp Lys Val Phe Val Ala Thr Asp Ala Val Arg 
                325                 330                 335     


Lys Glu Tyr Glu Glu Leu Lys Lys Leu Leu Pro Glu Met Val Arg Phe 
            340                 345                 350         


Glu Pro Thr Trp Glu Glu Leu Glu Leu Tyr Lys Asp Gly Gly Val Ala 
        355                 360                 365             


Ile Ile Asp Gln Trp Ile Cys Ala His Ala Arg Cys Leu Pro Thr Ser 
    370                 375                 380                 


Leu Ser Ala Glu Ser Gly Ser Gly Gly Phe Gln Arg Phe Phe Cys Pro 
385                 390                 395                 400 


Lys Tyr Ser Val Ser Glu Gln Met Val Ala Cys Val His Ser Gly His 
                405                 410                 415     


Phe His Thr Val Cys Leu Leu Val 
            420                 


<210>  56
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Thr Leu Ser Phe Val Phe Leu Leu Leu Gly Ala Val Ser Trp 
1               5                   10                  15      


Pro Pro Ala Ser Ala Ser Gly Gln Glu Phe Trp Pro Gly Gln Ser Ala 
            20                  25                  30          


Ala Asp Ile Leu Ser Gly Ala Ala Ser Arg Arg Arg Tyr Leu Leu Tyr 
        35                  40                  45              


Asp Val Asn Pro Pro Glu Gly Phe Asn Leu Arg Arg Asp Val Tyr Ile 
    50                  55                  60                  


Arg Ile Ala Ser Leu Leu Lys Thr Leu Leu Lys Thr Glu Glu Trp Val 
65                  70                  75                  80  


Leu Val Leu Pro Pro Trp Gly Arg Leu Tyr His Trp Gln Ser Pro Asp 
                85                  90                  95      


Ile His Gln Val Arg Ile Pro Trp Ser Glu Phe Phe Asp Leu Pro Ser 
            100                 105                 110         


Leu Asn Lys Asn Ile Pro Val Ile Glu Tyr Glu Gln Phe Ile Ala Glu 
        115                 120                 125             


Ser Gly Gly Pro Phe Ile Asp Gln Val Tyr Val Leu Gln Ser Tyr Ala 
    130                 135                 140                 


Glu Gly Trp Lys Glu Gly Thr Trp Glu Glu Lys Val Asp Glu Arg Pro 
145                 150                 155                 160 


Cys Ile Asp Gln Leu Leu Tyr Ser Gln Asp Lys His Glu Tyr Tyr Arg 
                165                 170                 175     


Gly Trp Phe Trp Gly Tyr Glu Glu Thr Arg Gly Leu Asn Val Ser Cys 
            180                 185                 190         


Leu Ser Val Gln Gly Ser Ala Ser Ile Val Ala Pro Leu Leu Leu Arg 
        195                 200                 205             


Asn Thr Ser Ala Arg Ser Val Met Leu Asp Arg Ala Glu Asn Leu Leu 
    210                 215                 220                 


His Asp His Tyr Gly Gly Lys Glu Tyr Trp Asp Thr Arg Arg Ser Met 
225                 230                 235                 240 


Val Phe Ala Arg His Leu Arg Glu Val Gly Asp Glu Phe Arg Ser Arg 
                245                 250                 255     


His Leu Asn Ser Thr Asp Asp Ala Asp Arg Ile Pro Phe Gln Glu Asp 
            260                 265                 270         


Trp Met Lys Met Lys Val Lys Leu Gly Ser Ala Leu Gly Gly Pro Tyr 
        275                 280                 285             


Leu Gly Val His Leu Arg Arg Lys Asp Phe Ile Trp Gly His Arg Gln 
    290                 295                 300                 


Asp Val Pro Ser Leu Glu Gly Ala Val Arg Lys Ile Arg Ser Leu Met 
305                 310                 315                 320 


Lys Thr His Arg Leu Asp Lys Val Phe Val Ala Thr Asp Ala Val Arg 
                325                 330                 335     


Lys Glu Tyr Glu Glu Leu Lys Lys Leu Leu Pro Glu Met Val Arg Phe 
            340                 345                 350         


Glu Pro Thr Trp Glu Glu Leu Glu Leu Tyr Lys Asp Gly Gly Val Ala 
        355                 360                 365             


Ile Ile Asp Gln Trp Ile Cys Ala His Ala Ser Ser 
    370                 375                 380 


<210>  57
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ser Leu Lys Ser Glu Arg Arg Gly Ile His Val Asp Gln Ser Asp 
1               5                   10                  15      


Leu Leu Cys Lys Lys Gly Cys Gly Tyr Tyr Gly Asn Pro Ala Trp Gln 
            20                  25                  30          


Gly Phe Cys Ser Lys Cys Trp Arg Glu Glu Tyr His Lys Ala Arg Gln 
        35                  40                  45              


Lys Gln Ile Gln Glu Asp Trp Glu Leu Ala Glu Arg Leu Gln Arg Glu 
    50                  55                  60                  


Glu Glu Glu Ala Phe Ala Ser Ser Gln Ser Ser Gln Gly Ala Gln Ser 
65                  70                  75                  80  


Leu Thr Phe Ser Lys Phe Glu Glu Lys Lys Thr Asn Glu Lys Thr Arg 
                85                  90                  95      


Lys Val Thr Thr Val Lys Lys Phe Phe Ser Ala Ser Ser Arg Val Gly 
            100                 105                 110         


Ser Lys Lys Glu Ile Gln Glu Ala Lys Ala Pro Ser Pro Ser Ile Asn 
        115                 120                 125             


Arg Gln Thr Ser Ile Glu Thr Asp Arg Val Ser Lys Glu Phe Ile Glu 
    130                 135                 140                 


Phe Leu Lys Thr Phe His Lys Thr Gly Gln Glu Ile Tyr Lys Gln Thr 
145                 150                 155                 160 


Lys Leu Phe Leu Glu Gly Met His Tyr Lys Arg Asp Leu Ser Ile Glu 
                165                 170                 175     


Glu Gln Ser Glu Cys Ala Gln Asp Phe Tyr His Asn Val Ala Glu Arg 
            180                 185                 190         


Met Gln Thr Arg Gly Lys Val Pro Pro Glu Arg Val Glu Lys Ile Met 
        195                 200                 205             


Asp Gln Ile Glu Lys Tyr Ile Met Thr Arg Leu Tyr Lys Tyr Val Phe 
    210                 215                 220                 


Cys Pro Glu Thr Thr Asp Asp Glu Lys Lys Asp Leu Ala Ile Gln Lys 
225                 230                 235                 240 


Arg Ile Arg Ala Leu Arg Trp Val Thr Pro Gln Met Leu Cys Val Pro 
                245                 250                 255     


Val Asn Glu Asp Ile Pro Glu Val Ser Asp Met Val Val Lys Ala Ile 
            260                 265                 270         


Thr Asp Ile Ile Glu Met Asp Ser Lys Arg Val Pro Arg Asp Lys Leu 
        275                 280                 285             


Ala Cys Ile Thr Lys Cys Ser Lys His Ile Phe Asn Ala Ile Lys Ile 
    290                 295                 300                 


Thr Lys Asn Glu Pro Ala Ser Ala Asp Asp Phe Leu Pro Thr Leu Ile 
305                 310                 315                 320 


Tyr Ile Val Leu Lys Gly Asn Pro Pro Arg Leu Gln Ser Asn Ile Gln 
                325                 330                 335     


Tyr Ile Thr Arg Phe Cys Asn Pro Ser Arg Leu Met Thr Gly Glu Asp 
            340                 345                 350         


Gly Tyr Tyr Phe Thr Asn Leu Cys Cys Ala Val Ala Phe Ile Glu Lys 
        355                 360                 365             


Leu Asp Ala Gln Ser Leu Asn Leu Ser Gln Glu Asp Phe Asp Arg Tyr 
    370                 375                 380                 


Met Ser Gly Gln Thr Ser Pro Arg Lys Gln Glu Ala Glu Ser Trp Ser 
385                 390                 395                 400 


Pro Asp Ala Cys Leu Gly Val Lys Gln Met Tyr Lys Asn Leu Asp Leu 
                405                 410                 415     


Leu Ser Gln Leu Asn Glu Arg Gln Glu Arg Ile Met Asn Glu Ala Lys 
            420                 425                 430         


Lys Leu Glu Lys Asp Leu Ile Asp Trp Thr Asp Gly Ile Ala Arg Glu 
        435                 440                 445             


Val Gln Asp Ile Val Glu Lys Tyr Pro Leu Glu Ile Lys Pro Pro Asn 
    450                 455                 460                 


Gln Pro Leu Ala Ala Ile Asp Ser Glu Asn Val Glu Asn Asp Lys Leu 
465                 470                 475                 480 


Pro Pro Pro Leu Gln Pro Gln Val Tyr Ala Gly 
                485                 490     


<210>  58
<211>  531
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ser Leu Lys Ser Glu Arg Arg Gly Ile His Val Asp Gln Ser Asp 
1               5                   10                  15      


Leu Leu Cys Lys Lys Gly Cys Gly Tyr Tyr Gly Asn Pro Ala Trp Gln 
            20                  25                  30          


Gly Phe Cys Ser Lys Cys Trp Arg Glu Glu Tyr His Lys Ala Arg Gln 
        35                  40                  45              


Lys Gln Ile Gln Glu Asp Trp Glu Leu Ala Glu Arg Ala Leu Leu Cys 
    50                  55                  60                  


Tyr Pro Gly Trp Ser Ala Met Val Gln Phe Gln Leu Thr Ala Thr Ser 
65                  70                  75                  80  


Ala Ser Trp Ala Gln Val Ile Leu Leu Leu Gln Pro Pro Lys Trp Leu 
                85                  90                  95      


Gly Leu Gln Lys Leu Gln Arg Glu Glu Glu Glu Ala Phe Ala Ser Ser 
            100                 105                 110         


Gln Ser Ser Gln Gly Ala Gln Ser Leu Thr Phe Ser Lys Phe Glu Glu 
        115                 120                 125             


Lys Lys Thr Asn Glu Lys Thr Arg Lys Val Thr Thr Val Lys Lys Phe 
    130                 135                 140                 


Phe Ser Ala Ser Ser Arg Val Gly Ser Lys Lys Glu Ile Gln Glu Ala 
145                 150                 155                 160 


Lys Ala Pro Ser Pro Ser Ile Asn Arg Gln Thr Ser Ile Glu Thr Asp 
                165                 170                 175     


Arg Val Ser Lys Glu Phe Ile Glu Phe Leu Lys Thr Phe His Lys Thr 
            180                 185                 190         


Gly Gln Glu Ile Tyr Lys Gln Thr Lys Leu Phe Leu Glu Gly Met His 
        195                 200                 205             


Tyr Lys Arg Asp Leu Ser Ile Glu Glu Gln Ser Glu Cys Ala Gln Asp 
    210                 215                 220                 


Phe Tyr His Asn Val Ala Glu Arg Met Gln Thr Arg Gly Lys Val Pro 
225                 230                 235                 240 


Pro Glu Arg Val Glu Lys Ile Met Asp Gln Ile Glu Lys Tyr Ile Met 
                245                 250                 255     


Thr Arg Leu Tyr Lys Tyr Val Phe Cys Pro Glu Thr Thr Asp Asp Glu 
            260                 265                 270         


Lys Lys Asp Leu Ala Ile Gln Lys Arg Ile Arg Ala Leu Arg Trp Val 
        275                 280                 285             


Thr Pro Gln Met Leu Cys Val Pro Val Asn Glu Asp Ile Pro Glu Val 
    290                 295                 300                 


Ser Asp Met Val Val Lys Ala Ile Thr Asp Ile Ile Glu Met Asp Ser 
305                 310                 315                 320 


Lys Arg Val Pro Arg Asp Lys Leu Ala Cys Ile Thr Lys Cys Ser Lys 
                325                 330                 335     


His Ile Phe Asn Ala Ile Lys Ile Thr Lys Asn Glu Pro Ala Ser Ala 
            340                 345                 350         


Asp Asp Phe Leu Pro Thr Leu Ile Tyr Ile Val Leu Lys Gly Asn Pro 
        355                 360                 365             


Pro Arg Leu Gln Ser Asn Ile Gln Tyr Ile Thr Arg Phe Cys Asn Pro 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Glu Asp Gly Tyr Tyr Phe Thr Asn Leu Cys 
385                 390                 395                 400 


Cys Ala Val Ala Phe Ile Glu Lys Leu Asp Ala Gln Ser Leu Asn Leu 
                405                 410                 415     


Ser Gln Glu Asp Phe Asp Arg Tyr Met Ser Gly Gln Thr Ser Pro Arg 
            420                 425                 430         


Lys Gln Glu Ala Glu Ser Trp Ser Pro Asp Ala Cys Leu Gly Val Lys 
        435                 440                 445             


Gln Met Tyr Lys Asn Leu Asp Leu Leu Ser Gln Leu Asn Glu Arg Gln 
    450                 455                 460                 


Glu Arg Ile Met Asn Glu Ala Lys Lys Leu Glu Lys Asp Leu Ile Asp 
465                 470                 475                 480 


Trp Thr Asp Gly Ile Ala Arg Glu Val Gln Asp Ile Val Glu Lys Tyr 
                485                 490                 495     


Pro Leu Glu Ile Lys Pro Pro Asn Gln Pro Leu Ala Ala Ile Asp Ser 
            500                 505                 510         


Glu Asn Val Glu Asn Asp Lys Leu Pro Pro Pro Leu Gln Pro Gln Val 
        515                 520                 525             


Tyr Ala Gly 
    530     


<210>  59
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Met Ala Ser Ser Tyr His Glu Val Val Ser Arg Lys Lys Met Ser 
1               5                   10                  15      


Leu Lys Ser Glu Arg Arg Gly Ile His Val Asp Gln Ser Asp Leu Leu 
            20                  25                  30          


Cys Lys Lys Gly Cys Gly Tyr Tyr Gly Asn Pro Ala Trp Gln Gly Phe 
        35                  40                  45              


Cys Ser Lys Cys Trp Arg Glu Glu Tyr His Lys Ala Arg Gln Lys Gln 
    50                  55                  60                  


Ile Gln Glu Asp Trp Glu Leu Ala Glu Arg Leu Gln Arg Glu Glu Glu 
65                  70                  75                  80  


Glu Ala Phe Ala Ser Ser Gln Ser Ser Gln Gly Ala Gln Ser Leu Thr 
                85                  90                  95      


Phe Ser Lys Phe Glu Glu Lys Lys Thr Asn Glu Lys Thr Arg Lys Val 
            100                 105                 110         


Thr Thr Val Lys Lys Phe Phe Ser Ala Ser Ser Arg Val Gly Ser Lys 
        115                 120                 125             


Lys Glu Ile Gln Glu Ala Lys Ala Pro Ser Pro Ser Ile Asn Arg Gln 
    130                 135                 140                 


Thr Ser Ile Glu Thr Asp Arg Val Ser Lys Glu Phe Ile Glu Phe Leu 
145                 150                 155                 160 


Lys Thr Phe His Lys Thr Gly Gln Glu Ile Tyr Lys Gln Thr Lys Leu 
                165                 170                 175     


Phe Leu Glu Gly Met His Tyr Lys Arg Asp Leu Ser Ile Glu Glu Gln 
            180                 185                 190         


Ser Glu Cys Ala Gln Asp Phe Tyr His Asn Val Ala Glu Arg Met Gln 
        195                 200                 205             


Thr Arg Gly Lys Val Pro Pro Glu Arg Val Glu Lys Ile Met Asp Gln 
    210                 215                 220                 


Ile Glu Lys Tyr Ile Met Thr Arg Leu Tyr Lys Tyr Val Phe Cys Pro 
225                 230                 235                 240 


Glu Thr Thr Asp Asp Glu Lys Lys Asp Leu Ala Ile Gln Lys Arg Ile 
                245                 250                 255     


Arg Ala Leu Arg Trp Val Thr Pro Gln Met Leu Cys Val Pro Val Asn 
            260                 265                 270         


Glu Asp Ile Pro Glu Val Ser Asp Met Val Val Lys Ala Ile Thr Asp 
        275                 280                 285             


Ile Ile Glu Met Asp Ser Lys Arg Val Pro Arg Asp Lys Leu Ala Cys 
    290                 295                 300                 


Ile Thr Lys Cys Ser Lys His Ile Phe Asn Ala Ile Lys Ile Thr Lys 
305                 310                 315                 320 


Asn Glu Pro Ala Ser Ala Asp Asp Phe Leu Pro Thr Leu Ile Tyr Ile 
                325                 330                 335     


Val Leu Lys Gly Asn Pro Pro Arg Leu Gln Ser Asn Ile Gln Tyr Ile 
            340                 345                 350         


Thr Arg Phe Cys Asn Pro Ser Arg Leu Met Thr Gly Glu Asp Gly Tyr 
        355                 360                 365             


Tyr Phe Thr Asn Leu Cys Cys Ala Val Ala Phe Ile Glu Lys Leu Asp 
    370                 375                 380                 


Ala Gln Ser Leu Asn Leu Ser Gln Glu Asp Phe Asp Arg Tyr Met Ser 
385                 390                 395                 400 


Gly Gln Thr Ser Pro Arg Lys Gln Glu Ala Glu Ser Trp Ser Pro Asp 
                405                 410                 415     


Ala Cys Leu Gly Val Lys Gln Met Tyr Lys Asn Leu Asp Leu Leu Ser 
            420                 425                 430         


Gln Leu Asn Glu Arg Gln Glu Arg Ile Met Asn Glu Ala Lys Lys Leu 
        435                 440                 445             


Glu Lys Asp Leu Ile Asp Trp Thr Asp Gly Ile Ala Arg Glu Val Gln 
    450                 455                 460                 


Asp Ile Val Glu Lys Tyr Pro Leu Glu Ile Lys Pro Pro Asn Gln Pro 
465                 470                 475                 480 


Leu Ala Ala Ile Asp Ser Glu Asn Val Glu Asn Asp Lys Leu Pro Pro 
                485                 490                 495     


Pro Leu Gln Pro Gln Val Tyr Ala Gly 
            500                 505 


<210>  60
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Val Lys Leu Phe Ile Gly Asn Leu Pro Arg Glu Ala Thr Glu Gln 
1               5                   10                  15      


Glu Ile Arg Ser Leu Phe Glu Gln Tyr Gly Lys Val Leu Glu Cys Asp 
            20                  25                  30          


Ile Ile Lys Asn Tyr Gly Phe Val His Ile Glu Asp Lys Thr Ala Ala 
        35                  40                  45              


Glu Asp Ala Ile Arg Asn Leu His His Tyr Lys Leu His Gly Val Asn 
    50                  55                  60                  


Ile Asn Val Glu Ala Ser Lys Asn Lys Ser Lys Thr Ser Thr Lys Leu 
65                  70                  75                  80  


His Val Gly Asn Ile Ser Pro Thr Cys Thr Asn Lys Glu Leu Arg Ala 
                85                  90                  95      


Lys Phe Glu Glu Tyr Gly Pro Val Ile Glu Cys Asp Ile Val Lys Asp 
            100                 105                 110         


Tyr Ala Phe Val His Met Glu Arg Ala Glu Asp Ala Val Glu Ala Ile 
        115                 120                 125             


Arg Gly Leu Asp Asn Thr Glu Phe Gln Gly Lys Arg Met His Val Gln 
    130                 135                 140                 


Leu Ser Thr Ser Arg Leu Arg Thr Ala Pro Gly Met Gly Asp Gln Ser 
145                 150                 155                 160 


Gly Cys Tyr Arg Cys Gly Lys Glu Gly His Trp Ser Lys Glu Cys Pro 
                165                 170                 175     


Ile Asp Arg Ser Gly Arg Val Ala Asp Leu Thr Glu Gln Tyr Asn Glu 
            180                 185                 190         


Gln Tyr Gly Ala Val Arg Thr Pro Tyr Thr Met Ser Tyr Gly Asp Ser 
        195                 200                 205             


Leu Tyr Tyr Asn Asn Ala Tyr Gly Ala Leu Asp Ala Tyr Tyr Lys Arg 
    210                 215                 220                 


Cys Arg Ala Ala Arg Ser Tyr Glu Ala Val Ala Ala Ala Ala Ala Ser 
225                 230                 235                 240 


Val Tyr Asn Tyr Ala Glu Gln Thr Leu Ser Gln Leu Pro Gln Val Gln 
                245                 250                 255     


Asn Thr Ala Met Ala Ser His Leu Thr Ser Thr Ser Leu Asp Pro Tyr 
            260                 265                 270         


Asp Arg His Leu Leu Pro Thr Ser Gly Ala Ala Ala Thr Ala Ala Ala 
        275                 280                 285             


Ala Ala Ala Ala Ala Ala Ala Val Thr Ala Ala Ser Thr Ser Tyr Tyr 
    290                 295                 300                 


Gly Arg Asp Arg Ser Pro Leu Arg Arg Ala Thr Ala Pro Val Pro Thr 
305                 310                 315                 320 


Val Gly Glu Gly Tyr Gly Tyr Gly His Glu Ser Glu Leu Ser Gln Ala 
                325                 330                 335     


Ser Ala Ala Ala Arg Asn Ser Leu Tyr Asp Met Ala Arg Tyr Glu Arg 
            340                 345                 350         


Glu Gln Tyr Ala Asp Arg Ala Arg Tyr Ser Ala Phe 
        355                 360                 


<210>  61
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Val Lys Leu Phe Ile Gly Asn Leu Pro Arg Glu Ala Thr Glu Gln 
1               5                   10                  15      


Glu Ile Arg Ser Leu Phe Glu Gln Tyr Gly Lys Val Leu Glu Cys Asp 
            20                  25                  30          


Ile Ile Lys Asn Tyr Gly Phe Val His Ile Glu Asp Lys Thr Ala Ala 
        35                  40                  45              


Glu Asp Ala Ile Arg Asn Leu His His Tyr Lys Leu His Gly Val Asn 
    50                  55                  60                  


Ile Asn Val Glu Ala Ser Lys Asn Lys Ser Lys Thr Ser Thr Lys Leu 
65                  70                  75                  80  


His Val Gly Asn Ile Ser Pro Thr Cys Thr Asn Lys Glu Leu Arg Ala 
                85                  90                  95      


Lys Phe Glu Glu Tyr Gly Pro Val Ile Glu Cys Asp Ile Val Lys Asp 
            100                 105                 110         


Tyr Ala Phe Val His Met Glu Arg Ala Glu Asp Ala Val Glu Ala Ile 
        115                 120                 125             


Arg Gly Leu Asp Asn Thr Glu Phe Gln Gly Glu Pro Pro Ser Leu Gly 
    130                 135                 140                 


Arg Gly Leu Asn Thr Arg Leu Cys Ala Glu Asn Gly Trp Ile Ser Lys 
145                 150                 155                 160 


Arg Arg Gly Leu Val Lys Ile Thr Ala Val Gly Trp Leu Val Met Lys 
                165                 170                 175     


Lys 
    


<210>  62
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Val Lys Leu Phe Ile Gly Asn Leu Pro Arg Glu Ala Thr Glu Gln 
1               5                   10                  15      


Glu Ile Arg Ser Leu Phe Glu Gln Tyr Gly Lys Val Leu Glu Cys Asp 
            20                  25                  30          


Ile Ile Lys Asn Tyr Gly Phe Val His Ile Glu Asp Lys Thr Ala Ala 
        35                  40                  45              


Glu Asp Ala Ile Arg Asn Leu His His Tyr Lys Leu His Gly Val Asn 
    50                  55                  60                  


Ile Asn Val Glu Ala Ser Lys Asn Lys Ser Lys Thr Ser Thr Lys Leu 
65                  70                  75                  80  


His Val Gly Asn Ile Ser Pro Thr Cys Thr Asn Lys Glu Leu Arg Ala 
                85                  90                  95      


Lys Phe Glu Glu Tyr Gly Pro Val Ile Glu Cys Asp Ile Val Lys Asp 
            100                 105                 110         


Tyr Ala Phe Val His Met Glu Arg Ala Glu Asp Ala Val Glu Ala Ile 
        115                 120                 125             


Arg Gly Leu Asp Asn Thr Glu Phe Gln Gly Gly Met Cys Val Gly 
    130                 135                 140             


<210>  63
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Val Lys Leu Phe Ile Gly Asn Leu Pro Arg Glu Ala Thr Glu Gln 
1               5                   10                  15      


Glu Ile Arg Ser Leu Phe Glu Gln Tyr Gly Lys Val Leu Glu Cys Asp 
            20                  25                  30          


Ile Ile Lys Asn Tyr Gly Phe Val His Ile Glu Asp Lys Thr Ala Ala 
        35                  40                  45              


Glu Asp Ala Ile Arg Asn Leu His His Tyr Lys Leu His Gly Val Asn 
    50                  55                  60                  


Ile Asn Val Glu Ala Ser Lys Asn Lys Ser Lys Thr Ser Thr Lys Leu 
65                  70                  75                  80  


His Val Gly Asn Ile Ser Pro Thr Cys Thr Asn Lys Glu Leu Arg Ala 
                85                  90                  95      


Lys Phe Glu Glu Tyr Gly Pro Val Ile Glu Cys Asp Ile Val Lys Asp 
            100                 105                 110         


Tyr Ala Phe Val His Met Glu Arg Ala Glu Asp Ala Val Glu Ala Ile 
        115                 120                 125             


Arg Gly Leu Asp Asn Thr Glu Phe Gln Gly Lys Ile Thr Pro Val Thr 
    130                 135                 140                 


Glu Gly Tyr Cys Cys Cys Asn Lys Gly His Thr Tyr Ile Phe Lys Asn 
145                 150                 155                 160 


Cys Asn Leu Ile Leu Glu Ser Arg Lys Ser Arg Arg Cys 
                165                 170             


<210>  64
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Glu Ala Glu Val Asp Lys Leu Glu Leu Met Phe Gln Lys Ala Glu 
1               5                   10                  15      


Ser Asp Leu Asp Tyr Ile Gln Tyr Arg Leu Glu Tyr Glu Ile Lys Thr 
            20                  25                  30          


Asn His Pro Asp Ser Ala Ser Glu Lys Asn Pro Val Thr Leu Leu Lys 
        35                  40                  45              


Glu Leu Ser Val Ile Lys Ser Arg Tyr Gln Thr Leu Tyr Ala Arg Phe 
    50                  55                  60                  


Lys Pro Val Ala Val Glu Gln Lys Glu Ser Lys Ser Arg Ile Cys Ala 
65                  70                  75                  80  


Thr Val Lys Lys Thr Met Asn Met Ile Gln Lys Leu Gln Lys Gln Thr 
                85                  90                  95      


Asp Leu Glu Leu Ser Pro Leu Thr Lys Glu Glu Lys Thr Ala Ala Glu 
            100                 105                 110         


Gln Phe Lys Phe His Met Pro Asp Leu 
        115                 120     


<210>  65
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ala Ser Glu Val Gly His Asn Leu Glu Ser Pro Glu Thr Pro Gly 
1               5                   10                  15      


Gly Gly Gly Trp Thr Arg Val Glu Phe Pro Pro Pro Ala Pro Lys Gly 
            20                  25                  30          


Ala Ala Thr Val Trp Cys Leu Asn Arg Leu Gly Ser Arg Lys Leu Ser 
        35                  40                  45              


Leu Ile Trp Ile Thr Phe Asn Thr Gly Trp Asn Met Lys Ser Arg Leu 
    50                  55                  60                  


Ile Ile Leu Ile Gln Gln Val Ser Cys His His 
65                  70                  75  


<210>  66
<211>  506
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Lys Lys Ala Glu Met Gly Arg Phe Ser Ile Ser Pro Asp Glu Asp 
1               5                   10                  15      


Ser Ser Ser Tyr Ser Ser Asn Ser Asp Phe Asn Tyr Ser Tyr Pro Thr 
            20                  25                  30          


Lys Gln Ala Ala Leu Lys Ser His Tyr Ala Asp Val Asp Pro Glu Asn 
        35                  40                  45              


Gln Asn Phe Leu Leu Glu Ser Asn Leu Gly Lys Lys Lys Tyr Glu Thr 
    50                  55                  60                  


Glu Phe His Pro Gly Thr Thr Ser Phe Gly Met Ser Val Phe Asn Leu 
65                  70                  75                  80  


Ser Asn Ala Ile Val Gly Ser Gly Ile Leu Gly Leu Ser Tyr Ala Met 
                85                  90                  95      


Ala Asn Thr Gly Ile Ala Leu Phe Ile Ile Leu Leu Thr Phe Val Ser 
            100                 105                 110         


Ile Phe Ser Leu Tyr Ser Val His Leu Leu Leu Lys Thr Ala Asn Glu 
        115                 120                 125             


Gly Gly Ser Leu Leu Tyr Glu Gln Leu Gly Tyr Lys Ala Phe Gly Leu 
    130                 135                 140                 


Val Gly Lys Leu Ala Ala Ser Gly Ser Ile Thr Met Gln Asn Ile Gly 
145                 150                 155                 160 


Ala Met Ser Ser Tyr Leu Phe Ile Val Lys Tyr Glu Leu Pro Leu Val 
                165                 170                 175     


Ile Gln Ala Leu Thr Asn Ile Glu Asp Lys Thr Gly Leu Trp Tyr Leu 
            180                 185                 190         


Asn Gly Asn Tyr Leu Val Leu Leu Val Ser Leu Val Val Ile Leu Pro 
        195                 200                 205             


Leu Ser Leu Phe Arg Asn Leu Gly Tyr Leu Gly Tyr Thr Ser Gly Leu 
    210                 215                 220                 


Ser Leu Leu Cys Met Val Phe Phe Leu Ile Val Val Ile Cys Lys Lys 
225                 230                 235                 240 


Phe Gln Val Pro Cys Pro Val Glu Ala Ala Leu Ile Ile Asn Glu Thr 
                245                 250                 255     


Ile Asn Thr Thr Leu Thr Gln Pro Thr Ala Leu Val Pro Ala Leu Ser 
            260                 265                 270         


His Asn Val Thr Glu Asn Asp Ser Cys Arg Pro His Tyr Phe Ile Phe 
        275                 280                 285             


Asn Ser Gln Thr Val Tyr Ala Val Pro Ile Leu Ile Phe Ser Phe Val 
    290                 295                 300                 


Cys His Pro Ala Val Leu Pro Ile Tyr Glu Glu Leu Lys Asp Arg Ser 
305                 310                 315                 320 


Arg Arg Arg Met Met Asn Val Ser Lys Ile Ser Phe Phe Ala Met Phe 
                325                 330                 335     


Leu Met Tyr Leu Leu Ala Ala Leu Phe Gly Tyr Leu Thr Phe Tyr Glu 
            340                 345                 350         


His Val Glu Ser Glu Leu Leu His Thr Tyr Ser Ser Ile Leu Gly Thr 
        355                 360                 365             


Asp Ile Leu Leu Leu Ile Val Arg Leu Ala Val Leu Met Ala Val Thr 
    370                 375                 380                 


Leu Thr Val Pro Val Val Ile Phe Pro Ile Arg Ser Ser Val Thr His 
385                 390                 395                 400 


Leu Leu Cys Ala Ser Lys Asp Phe Ser Trp Trp Arg His Ser Leu Ile 
                405                 410                 415     


Thr Val Ser Ile Leu Ala Phe Thr Asn Leu Leu Val Ile Phe Val Pro 
            420                 425                 430         


Thr Ile Arg Asp Ile Phe Gly Phe Ile Gly Ala Ser Ala Ala Ser Met 
        435                 440                 445             


Leu Ile Phe Ile Leu Pro Ser Ala Phe Tyr Ile Lys Leu Val Lys Lys 
    450                 455                 460                 


Glu Pro Met Lys Ser Val Gln Lys Ile Gly Ala Leu Phe Phe Leu Leu 
465                 470                 475                 480 


Ser Gly Val Leu Val Met Thr Gly Ser Met Ala Leu Ile Val Leu Asp 
                485                 490                 495     


Trp Val His Asn Ala Pro Gly Gly Gly His 
            500                 505     


<210>  67
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Lys Gln Asn Leu Ile Leu Leu Thr Phe Val Ser Ile Phe Ser Leu 
1               5                   10                  15      


Tyr Ser Val His Leu Leu Leu Lys Thr Ala Asn Glu Gly Gly Ser Leu 
            20                  25                  30          


Leu Tyr Glu Gln Leu Gly Tyr Lys Ala Phe Gly Leu Val Gly Lys Leu 
        35                  40                  45              


Ala Ala Ser Gly Ser Ile Thr Met Gln Asn Ile Gly Ala Met Ser Ser 
    50                  55                  60                  


Tyr Leu Phe Ile Val Lys Tyr Glu Leu Pro Leu Val Ile Gln Ala Leu 
65                  70                  75                  80  


Thr Asn Ile Glu Asp Lys Thr Gly Leu Trp Tyr Leu Asn Gly Asn Tyr 
                85                  90                  95      


Leu Val Leu Leu Val Ser Leu Val Val Ile Leu Pro Leu Ser Leu Phe 
            100                 105                 110         


Arg Asn Leu Gly Tyr Leu Gly Tyr Thr Ser Gly Leu Ser Leu Leu Cys 
        115                 120                 125             


Met Val Phe Phe Leu Ile Val Val Ile Cys Lys Lys Phe Gln Val Pro 
    130                 135                 140                 


Cys Pro Val Glu Ala Ala Leu Ile Ile Asn Glu Thr Ile Asn Thr Thr 
145                 150                 155                 160 


Leu Thr Gln Pro Thr Ala Leu Val Pro Ala Leu Ser His Asn Val Thr 
                165                 170                 175     


Glu Asn Asp Ser Cys Arg Pro His Tyr Phe Ile Phe Asn Ser Gln Thr 
            180                 185                 190         


Val Tyr Ala Val Pro Ile Leu Ile Phe Ser Phe Val Cys His Pro Ala 
        195                 200                 205             


Val Leu Pro Ile Tyr Glu Glu Leu Lys Asp Arg Ser Arg Arg Arg Met 
    210                 215                 220                 


Met Asn Val Ser Lys Ile Ser Phe Phe Ala Met Phe Leu Met Tyr Leu 
225                 230                 235                 240 


Leu Ala Ala Leu Phe Gly Tyr Leu Thr Phe Tyr Glu His Val Glu Ser 
                245                 250                 255     


Glu Leu Leu His Thr Tyr Ser Ser Ile Leu Gly Thr Asp Ile Leu Leu 
            260                 265                 270         


Leu Ile Val Arg Leu Ala Val Leu Met Ala Val Thr Leu Thr Val Pro 
        275                 280                 285             


Val Val Ile Phe Pro Ile Arg Ser Ser Val Thr His Leu Leu Cys Ala 
    290                 295                 300                 


Ser Lys Asp Phe Ser Trp Trp Arg His Ser Leu Ile Thr Val Ser Ile 
305                 310                 315                 320 


Leu Ala Phe Thr Asn Leu Leu Val Ile Phe Val Pro Thr Ile Arg Asp 
                325                 330                 335     


Ile Phe Gly Phe Ile Gly Ala Ser Ala Ala Ser Met Leu Ile Phe Ile 
            340                 345                 350         


Leu Pro Ser Ala Phe Tyr Ile Lys Leu Val Lys Lys Glu Pro Met Lys 
        355                 360                 365             


Ser Val Gln Lys Ile Gly Ala Leu Phe Phe Leu Leu Ser Gly Val Leu 
    370                 375                 380                 


Val Met Thr Gly Ser Met Ala Leu Ile Val Leu Asp Trp Val His Asn 
385                 390                 395                 400 


Ala Pro Gly Gly Gly His 
                405     


<210>  68
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Val Lys Leu Thr Ala Glu Leu Ile Glu Gln Ala Ala Gln Tyr Thr 
1               5                   10                  15      


Asn Ala Val Arg Asp Arg Glu Leu Asp Leu Arg Gly Tyr Lys Ile Pro 
            20                  25                  30          


Val Ile Glu Asn Leu Gly Ala Thr Leu Asp Gln Phe Asp Ala Ile Asp 
        35                  40                  45              


Phe Ser Asp Asn Glu Ile Arg Lys Leu Asp Gly Phe Pro Leu Leu Arg 
    50                  55                  60                  


Arg Leu Lys Thr Leu Leu Val Asn Asn Asn Arg Ile Cys Arg Ile Gly 
65                  70                  75                  80  


Glu Gly Leu Asp Gln Ala Leu Pro Cys Leu Thr Glu Leu Ile Leu Thr 
                85                  90                  95      


Asn Asn Ser Leu Val Glu Leu Gly Asp Leu Asp Pro Leu Ala Ser Leu 
            100                 105                 110         


Lys Ser Leu Thr Tyr Leu Ser Ile Leu Arg Asn Pro Val Thr Asn Lys 
        115                 120                 125             


Lys His Tyr Arg Leu Tyr Val Ile Tyr Lys Val Pro Gln Val Arg Val 
    130                 135                 140                 


Leu Asp Phe Gln Lys Val Lys Leu Lys Glu Arg Gln Glu Ala Glu Lys 
145                 150                 155                 160 


Met Phe Lys Gly Lys Arg Gly Ala Gln Leu Ala Lys Asp Ile Ala Arg 
                165                 170                 175     


Arg Ser Lys Thr Phe Asn Pro Gly Ala Gly Leu Pro Thr Asp Lys Lys 
            180                 185                 190         


Lys Gly Gly Pro Ser Pro Gly Asp Val Glu Ala Ile Lys Asn Ala Ile 
        195                 200                 205             


Ala Asn Ala Ser Thr Leu Ala Glu Val Glu Arg Leu Lys Gly Leu Leu 
    210                 215                 220                 


Gln Ser Gly Gln Ile Pro Gly Arg Glu Arg Arg Ser Gly Pro Thr Asp 
225                 230                 235                 240 


Asp Gly Glu Glu Glu Met Glu Glu Asp Thr Val Thr Asn Gly Ser 
                245                 250                 255 


<210>  69
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Ala Ala Ala Ala Val Gln Gly Gly Arg Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Cys Ser Gly Ala Gly Gly Ala Ser Asn Cys Gly Thr Gly Ser Gly Arg 
            20                  25                  30          


Ser Gly Leu Leu Asp Lys Trp Lys Ile Asp Asp Lys Pro Val Lys Ile 
        35                  40                  45              


Asp Lys Trp Asp Gly Ser Ala Val Lys Asn Ser Leu Asp Asp Ser Ala 
    50                  55                  60                  


Lys Lys Val Leu Leu Glu Lys Tyr Lys Tyr Val Glu Asn Phe Gly Leu 
65                  70                  75                  80  


Ile Asp Gly Arg Leu Thr Ile Cys Thr Ile Ser Cys Phe Phe Ala Ile 
                85                  90                  95      


Val Ala Leu Ile Trp Asp Tyr Met His Pro Phe Pro Glu Ser Lys Pro 
            100                 105                 110         


Val Leu Ala Leu Cys Val Ile Ser Tyr Phe Val Met Met Gly Ile Leu 
        115                 120                 125             


Thr Ile Tyr Thr Ser Tyr Lys Glu Lys Ser Ile Phe Leu Val Ala His 
    130                 135                 140                 


Arg Lys Asp Pro Thr Gly Met Asp Pro Asp Asp Ile Trp Gln Leu Ser 
145                 150                 155                 160 


Ser Ser Leu Lys Arg Phe Asp Asp Lys Tyr Thr Leu Lys Leu Thr Phe 
                165                 170                 175     


Ile Ser Gly Arg Thr Lys Gln Gln Arg Glu Ala Glu Phe Thr Lys Ser 
            180                 185                 190         


Ile Ala Lys Phe Phe Asp His Ser Gly Thr Leu Val Met Asp Ala Tyr 
        195                 200                 205             


Glu Pro Glu Ile Ser Arg Leu His Asp Ser Leu Ala Ile Glu Arg Lys 
    210                 215                 220                 


Ile Lys 
225     


<210>  70
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Asp Lys Ser Gly Ile Asp Ser Leu Asp His Val Thr Ser Asp Ala 
1               5                   10                  15      


Val Glu Leu Ala Asn Arg Ser Asp Asn Ser Ser Asp Ser Ser Leu Phe 
            20                  25                  30          


Lys Thr Gln Cys Ile Pro Tyr Ser Pro Lys Gly Glu Lys Arg Asn Pro 
        35                  40                  45              


Ile Arg Lys Phe Val Arg Thr Pro Glu Ser Val His Ala Ser Asp Ser 
    50                  55                  60                  


Ser Ser Asp Ser Ser Phe Glu Pro Ile Pro Leu Thr Ile Lys Ala Ile 
65                  70                  75                  80  


Phe Glu Arg Phe Lys Asn Arg Lys Lys Arg Tyr Lys Lys Lys Lys Lys 
                85                  90                  95      


Arg Arg Tyr Gln Pro Thr Gly Arg Pro Arg Gly Arg Pro Glu Gly Arg 
            100                 105                 110         


Arg Asn Pro Ile Tyr Ser Leu Ile Asp Lys Lys Lys Gln Phe Arg Ser 
        115                 120                 125             


Arg Gly Ser Gly Phe Pro Phe Leu Glu Ser Glu Asn Glu Lys Asn Ala 
    130                 135                 140                 


Pro Trp Arg Lys Ile Leu Thr Phe Glu Gln Ala Val Ala Arg Gly Phe 
145                 150                 155                 160 


Phe Asn Tyr Ile Glu Lys Leu Lys Tyr Glu His His Leu Lys Glu Ser 
                165                 170                 175     


Leu Lys Gln Met Asn Val Gly Glu Asp Leu Glu Asn Glu Asp Phe Asp 
            180                 185                 190         


Ser Arg Arg Tyr Lys Phe Leu Asp Asp Asp Gly Ser Ile Ser Pro Ile 
        195                 200                 205             


Glu Glu Ser Thr Ala Glu Asp Glu Asp Ala Thr His Leu Glu Asp Asn 
    210                 215                 220                 


Glu Cys Asp Ile Lys Leu Ala Gly Asp Ser Phe Ile Val Ser Ser Glu 
225                 230                 235                 240 


Phe Pro Val Arg Leu Ser Val Tyr Leu Glu Glu Glu Asp Ile Thr Glu 
                245                 250                 255     


Glu Ala Ala Leu Ser Lys Lys Arg Ala Thr Lys Ala Lys Asn Thr Gly 
            260                 265                 270         


Gln Arg Gly Leu Lys Met 
        275             


<210>  71
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210>  72
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Thr Pro Arg Met Lys Arg 
                85                  90                  95      


Leu Trp Ala Ala Lys 
            100     


<210>  73
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ser Gln Val Thr Phe Ser Asp Val Ala Ile Asp Phe Ser His Glu 
1               5                   10                  15      


Glu Trp Ala Cys Leu Asp Ser Ala Gln Arg Asp Leu Tyr Lys Asp Val 
            20                  25                  30          


Met Val Gln Asn Tyr Glu Asn Leu Val Ser Val Gly Leu Ser Val Thr 
        35                  40                  45              


Lys Pro Tyr Val Ile Met Leu Leu Glu Asp Gly Lys Glu Pro Trp Met 
    50                  55                  60                  


Met Glu Lys Lys Leu Ser Lys Ala Tyr Pro Phe Pro Leu Ser His Ser 
65                  70                  75                  80  


Val Pro Ala Ser Val Asn Phe Gly Phe Ser Ala Leu Phe Glu His Cys 
                85                  90                  95      


Ser Glu Val Thr Glu Ile Phe Glu Leu Ser Glu Leu Cys Val Phe Trp 
            100                 105                 110         


Val Leu His Phe Leu Ser Asn Ser Pro Asn Ser Thr Val Glu Ala Phe 
        115                 120                 125             


Ser Arg Ser Lys Lys Lys Lys Lys Lys Lys Lys Lys Arg Gln Cys Phe 
    130                 135                 140                 


Ala Phe Leu Ile Tyr Phe Arg Leu Gly Ile Lys Met Gly Lys Gln Gly 
145                 150                 155                 160 


Ile Ile Asn Lys Glu Gly Tyr Leu Tyr Glu Asp Ser Pro Gln Pro Val 
                165                 170                 175     


Thr Met Glu Lys Val Val Lys Gln Ser Tyr Glu Phe Ser Asn Ser Asn 
            180                 185                 190         


Lys Asn Leu Glu Tyr Thr Glu Cys Asp Thr Phe Arg Ser Thr Phe His 
        195                 200                 205             


Ser Lys Ser Thr Leu Ser Glu Pro Gln Asn Asn Ser Ala Glu Gly Asn 
    210                 215                 220                 


Ser His Lys Tyr Asp Ile Leu Lys Lys Asn Leu Ser Lys Lys Ser Val 
225                 230                 235                 240 


Ile Lys Ser Glu Arg Ile Asn Gly Gly Lys Lys Leu Leu Asn Ser Asn 
                245                 250                 255     


Lys Ser Gly Ala Ala Phe Asn Gln Ser Lys Ser Leu Thr Leu Pro Gln 
            260                 265                 270         


Thr Cys Asn Arg Glu Lys Ile Tyr Thr Cys Ser Glu Cys Gly Lys Ala 
        275                 280                 285             


Phe Gly Lys Gln Ser Ile Leu Ser Arg His Trp Arg Ile His Thr Gly 
    290                 295                 300                 


Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Thr Phe Ser His Gly 
305                 310                 315                 320 


Ser Ser Leu Thr Arg His Gln Ile Ser His Ser Gly Glu Lys Pro Tyr 
                325                 330                 335     


Lys Cys Ile Glu Cys Gly Lys Ala Phe Ser His Gly Ser Ser Leu Thr 
            340                 345                 350         


Asn His Gln Ser Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Met Asn 
        355                 360                 365             


Cys Gly Lys Ser Phe Ser Arg Val Ser Leu Leu Ile Gln His Leu Arg 
    370                 375                 380                 


Ile His Thr Gln Glu Lys Arg Tyr Glu Cys Arg Ile Cys Gly Lys Ala 
385                 390                 395                 400 


Phe Ile His Ser Ser Ser Leu Ile His His Gln Lys Ser His Thr Gly 
                405                 410                 415     


Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Ala Phe Cys Cys Ser 
            420                 425                 430         


Ser His Leu Thr Gln His Gln Arg Ile His Ser Met Lys Lys Lys Tyr 
        435                 440                 445             


Glu Cys Asn Lys Cys Leu Lys Val Phe Ser Ser Phe Ser Phe Leu Val 
    450                 455                 460                 


Gln His Gln Ser Ile His Thr Glu Glu Lys Pro Phe Glu Val 
465                 470                 475             


<210>  74
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ser Gln Val Thr Phe Ser Asp Val Ala Ile Asp Phe Ser His Glu 
1               5                   10                  15      


Glu Trp Ala Cys Leu Asp Ser Ala Gln Arg Asp Leu Tyr Lys Asp Val 
            20                  25                  30          


Met Val Gln Asn Tyr Glu Asn Leu Val Ser Val Gly Leu Ser Val Thr 
        35                  40                  45              


Lys Pro Tyr Val Ile Met Leu Leu Glu Asp Gly Lys Glu Pro Trp Met 
    50                  55                  60                  


Met Glu Lys Lys Leu Ser Lys Asp Trp Glu Ser Arg Trp Glu Asn Lys 
65                  70                  75                  80  


Glu Leu Ser Thr Lys Lys Asp Ile Tyr Asp Glu Asp Ser Pro Gln Pro 
                85                  90                  95      


Val Thr Met Glu Lys Val Val Lys Gln Ser Tyr Glu Phe Ser Asn Ser 
            100                 105                 110         


Asn Lys Asn Leu Glu Tyr Thr Glu Cys Asp Thr Phe Arg Ser Thr Phe 
        115                 120                 125             


His Ser Lys Ser Thr Leu Ser Glu Pro Gln Asn Asn Ser Ala Glu Gly 
    130                 135                 140                 


Asn Ser His Lys Tyr Asp Ile Leu Lys Lys Asn Leu Ser Lys Lys Ser 
145                 150                 155                 160 


Val Ile Lys Ser Glu Arg Ile Asn Gly Gly Lys Lys Leu Leu Asn Ser 
                165                 170                 175     


Asn Lys Ser Gly Ala Ala Phe Asn Gln Ser Lys Ser Leu Thr Leu Pro 
            180                 185                 190         


Gln Thr Cys Asn Arg Glu Lys Ile Tyr Thr Cys Ser Glu Cys Gly Lys 
        195                 200                 205             


Ala Phe Gly Lys Gln Ser Ile Leu Ser Arg His Trp Arg Ile His Thr 
    210                 215                 220                 


Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Thr Phe Ser His 
225                 230                 235                 240 


Gly Ser Ser Leu Thr Arg His Gln Ile Ser His Ser Gly Glu Lys Pro 
                245                 250                 255     


Tyr Lys Cys Ile Glu Cys Gly Lys Ala Phe Ser His Gly Ser Ser Leu 
            260                 265                 270         


Thr Asn His Gln Ser Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Met 
        275                 280                 285             


Asn Cys Gly Lys Ser Phe Ser Arg Val Ser Leu Leu Ile Gln His Leu 
    290                 295                 300                 


Arg Ile His Thr Gln Glu Lys Arg Tyr Glu Cys Arg Ile Cys Gly Lys 
305                 310                 315                 320 


Ala Phe Ile His Ser Ser Ser Leu Ile His His Gln Lys Ser His Thr 
                325                 330                 335     


Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Ala Phe Cys Cys 
            340                 345                 350         


Ser Ser His Leu Thr Gln His Gln Arg Ile His Ser Met Lys Lys Lys 
        355                 360                 365             


Tyr Glu Cys Asn Lys Cys Leu Lys Val Phe Ser Ser Phe Ser Phe Leu 
    370                 375                 380                 


Val Gln His Gln Ser Ile His Thr Glu Glu Lys Pro Phe Glu Val 
385                 390                 395                 


<210>  75
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Glu Ser Val Thr Phe Glu Asp Val Ala Val Glu Phe Ile Gln Glu 
1               5                   10                  15      


Trp Ala Leu Leu Asp Ser Ala Arg Arg Ser Leu Cys Lys Tyr Arg Met 
            20                  25                  30          


Leu Asp Gln Cys Arg Thr Leu Ala Ser Arg Gly Thr Pro Pro Cys Lys 
        35                  40                  45              


Pro Ser Cys Val Ser Gln Leu Gly Gln Arg Ala Glu Pro Lys Ala Thr 
    50                  55                  60                  


Glu Arg Gly Ile Leu Arg Ala Thr Gly Val Ala Trp Glu Ser Gln Leu 
65                  70                  75                  80  


Lys Pro Glu Glu Leu Pro Ser Met Gln Asp Leu Leu Glu Glu Ala Ser 
                85                  90                  95      


Ser Arg Asp Met Gln Met Gly Pro Gly Leu Phe Leu Arg Met Gln Leu 
            100                 105                 110         


Val Pro Ser Ile Glu Glu Arg Glu Thr Pro Leu Thr Arg Glu Asp Arg 
        115                 120                 125             


Pro Ala Leu Gln Glu Pro Pro Trp Ser Leu Gly Cys Thr Gly Leu Lys 
    130                 135                 140                 


Ala Ala Met Gln Ile Gln Arg Val Val Ile Pro Val Pro Thr Leu Gly 
145                 150                 155                 160 


His Arg Asn Pro Trp Val Ala Arg Asp Ser Ala Val Pro Ala Arg Asp 
                165                 170                 175     


Pro Ala Trp Leu Gln Glu Asp Lys Val Glu Glu Glu Ala Met Ala Pro 
            180                 185                 190         


Gly Leu Pro Thr Ala Cys Ser Gln Glu Pro Val Thr Phe Ala Asp Val 
        195                 200                 205             


Ala Val Val Phe Thr Pro Glu Glu Trp Val Phe Leu Asp Ser Thr Gln 
    210                 215                 220                 


Arg Ser Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Ala 
225                 230                 235                 240 


Ser Val Ala Asp Gln Leu Cys Lys Pro Asn Ala Leu Ser Tyr Leu Glu 
                245                 250                 255     


Glu Arg Gly Glu Gln Trp Thr Thr Asp Arg Gly Val Leu Ser Asp Thr 
            260                 265                 270         


Cys Ala Glu Pro Gln Cys Gln Pro Gln Glu Ala Ile Pro Ser Gln Asp 
        275                 280                 285             


Thr Phe Thr Glu Ile Leu Ser Ile Asp Val Lys Gly Glu Gln Pro Gln 
    290                 295                 300                 


Pro Gly Glu Lys Leu Tyr Lys Tyr Asn Glu Leu Glu Lys Pro Phe Asn 
305                 310                 315                 320 


Ser Ile Glu Pro Leu Phe Gln Tyr Gln Arg Ile His Ala Gly Glu Ala 
                325                 330                 335     


Ser Cys Glu Cys Gln Glu Ile Arg Asn Ser Phe Phe Gln Ser Ala His 
            340                 345                 350         


Leu Ile Val Pro Glu Lys Ile Arg Ser Gly Asp Lys Ser Tyr Ala Cys 
        355                 360                 365             


Asn Lys Cys Glu Lys Ser Phe Arg Tyr Ser Ser Asp Leu Ile Arg His 
    370                 375                 380                 


Glu Lys Thr His Thr Ala Glu Lys Cys Phe Asp Cys Gln Glu Cys Gly 
385                 390                 395                 400 


Gln Ala Phe Lys Tyr Ser Ser Asn Leu Arg Arg His Met Arg Thr His 
                405                 410                 415     


Thr Gly Glu Lys Pro Phe Glu Cys Ser Gln Cys Gly Lys Thr Phe Thr 
            420                 425                 430         


Arg Asn Phe Asn Leu Ile Leu His Gln Arg Asn His Thr Gly Glu Lys 
        435                 440                 445             


Pro Tyr Glu Cys Lys Asp Cys Gly Lys Ala Phe Asn Gln Pro Ser Ser 
    450                 455                 460                 


Leu Arg Ser His Val Arg Thr His Thr Gly Glu Lys Pro Phe Glu Cys 
465                 470                 475                 480 


Ser Gln Cys Gly Lys Ala Phe Arg Glu His Ser Ser Leu Lys Thr His 
                485                 490                 495     


Leu Arg Thr His Thr Arg Glu Lys Pro Tyr Glu Cys Asn Gln Cys Gly 
            500                 505                 510         


Lys Pro Phe Arg Thr Ser Thr His Leu Asn Val His Lys Arg Ile His 
        515                 520                 525             


Thr Gly Glu Lys Leu Tyr Glu Cys Ala Thr Cys Gly Gln Val Leu Ser 
    530                 535                 540                 


Arg Leu Ser Thr Leu Lys Ser His Met Arg Thr His Thr Gly Glu Lys 
545                 550                 555                 560 


Pro Tyr Val Cys Gln Glu Cys Gly Arg Ala Phe Ser Glu Pro Ser Ser 
                565                 570                 575     


Leu Arg Lys His Ala Arg Thr His Ser Gly Lys Lys Pro Tyr Ala Cys 
            580                 585                 590         


Gln Glu Cys Gly Arg Ala Phe Gly Gln Ser Ser His Leu Ile Val His 
        595                 600                 605             


Val Arg Thr His Ser Ala Gly Arg Pro Tyr Gln Cys Asn Gln Cys Glu 
    610                 615                 620                 


Lys Ala Phe Arg His Ser Ser Ser Leu Thr Val His Lys Arg Thr His 
625                 630                 635                 640 


Val Gly Arg Glu Thr Ile Arg Asn Gly Ser Leu Pro Leu Ser Met Ser 
                645                 650                 655     


His Pro Tyr Cys Gly Pro Leu Ala Asn 
            660                 665 


<210>  76
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Glu Ser Val Thr Phe Glu Asp Val Ala Val Glu Phe Ile Gln Glu 
1               5                   10                  15      


Trp Ala Leu Leu Asp Ser Ala Arg Arg Ser Leu Cys Lys Tyr Arg Met 
            20                  25                  30          


Leu Asp Gln Cys Arg Thr Leu Ala Ser Arg Gly Thr Pro Pro Cys Lys 
        35                  40                  45              


Pro Ser Cys Val Ser Gln Leu Gly Gln Arg Ala Glu Pro Lys Ala Thr 
    50                  55                  60                  


Glu Arg Gly Ile Leu Arg Ala Thr Gly Val Ala Trp Glu Ser Gln Leu 
65                  70                  75                  80  


Lys Pro Glu Glu Leu Pro Ser Met Gln Asp Leu Leu Glu Glu Ala Ser 
                85                  90                  95      


Ser Arg Asp Met Gln Met Gly Pro Gly Leu Phe Leu Arg Met Gln Leu 
            100                 105                 110         


Val Pro Ser Ile Glu Glu Arg Glu Thr Pro Leu Thr Arg Glu Asp Arg 
        115                 120                 125             


Pro Ala Leu Gln Glu Pro Pro Trp Ser Leu Gly Cys Thr Leu Pro Leu 
    130                 135                 140                 


Leu Ser Leu Leu Leu Pro Ser Cys Pro Glu Pro Pro Leu Val Leu Leu 
145                 150                 155                 160 


Asp Ser Ser Ser Ala Pro Asp Arg His Leu Gly Ser Thr Leu Asp Thr 
                165                 170                 175     


Glu Ala Arg Gly Ile Pro 
            180         


<210>  77
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Glu Ser Val Thr Phe Glu Asp Val Ala Val Glu Phe Ile Gln Glu 
1               5                   10                  15      


Trp Ala Leu Leu Asp Ser Ala Arg Arg Ser Leu Cys Lys Tyr Arg Met 
            20                  25                  30          


Leu Asp Gln Cys Arg Thr Leu Ala Ser Arg Gly Thr Pro Pro Cys Lys 
        35                  40                  45              


Pro Ser Cys Val Ser Gln Leu Gly Gln Arg Ala Glu Pro Lys Ala Thr 
    50                  55                  60                  


Glu Arg Gly Ile Leu Arg Ala Thr Gly Val Ala Trp Glu Ser Gln Leu 
65                  70                  75                  80  


Lys Pro Glu Glu Leu Pro Ser Met Gln Asp Leu Leu Glu Glu Ala Ser 
                85                  90                  95      


Ser Arg Asp Met Gln Met Gly Pro Gly Leu Phe Leu Arg Met Gln Leu 
            100                 105                 110         


Val Pro Ser Ile Glu Glu Arg Glu Thr Pro Leu Thr Arg Glu Asp Arg 
        115                 120                 125             


Pro Ala Leu Gln Glu Pro Pro Trp Ser Leu Gly Cys Thr Gly Leu Lys 
    130                 135                 140                 


Ala Ala Met Gln Ile Gln Arg Val Val Ile Pro Val Pro Thr Leu Gly 
145                 150                 155                 160 


His Arg Asn Pro Trp Val Ala Arg Asp Ser Ala Val Pro Ala Arg Asp 
                165                 170                 175     


Pro Ala Trp Leu Gln Glu Asp Lys Val Glu Glu Glu Ala Met Ala Pro 
            180                 185                 190         


Gly Leu Pro Thr Ala Cys Ser Gln Glu Pro Val Thr Phe Ala Asp Val 
        195                 200                 205             


Ala Val Val Phe Thr Pro Glu Glu Trp Val Phe Leu Asp Ser Thr Gln 
    210                 215                 220                 


Arg Ser Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Ala 
225                 230                 235                 240 


Ser Val Ala Asp Gln Leu Cys Lys Pro Asn Ala Leu Ser Tyr Leu Glu 
                245                 250                 255     


Glu Arg Gly Glu Gln Trp Thr Thr Asp Arg Gly Val Leu Ser Asp Thr 
            260                 265                 270         


Cys Ala Glu Pro Gln Cys Gln Pro Gln Glu Ala Ile Pro Ser Gln Asp 
        275                 280                 285             


Thr Phe Thr Glu Ile Leu Ser Ile Asp Val Lys Gly Pro Pro Asn 
    290                 295                 300             


<210>  78
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ala Ala Ala Ala Leu Arg Asp Pro Ala Gln Val Pro Val Ala Ala 
1               5                   10                  15      


Asp Leu Leu Thr Asp His Glu Glu Gly Tyr Val Thr Phe Glu Asp Val 
            20                  25                  30          


Ala Val Tyr Phe Ser Gln Glu Glu Trp Arg Leu Leu Asp Asp Ala Gln 
        35                  40                  45              


Arg Leu Leu Tyr Arg Asn Val Met Leu Glu Asn Phe Thr Leu Leu Ala 
    50                  55                  60                  


Ser Leu Gly Leu Ala Ser Ser Lys Thr His Glu Ile Thr Gln Leu Glu 
65                  70                  75                  80  


Ser Trp Glu Glu Pro Phe Met Pro Ala Trp Glu Val Val Thr Ser Ala 
                85                  90                  95      


Ile Pro Arg Gly Cys Trp His Gly Ala Glu Ala Glu Glu Ala Pro Glu 
            100                 105                 110         


Gln Ile Ala Ser Val Gly Leu Leu Ser Ser Asn Ile Gln Gln His Gln 
        115                 120                 125             


Lys Gln His Cys Gly Glu Lys Pro Leu Lys Arg Gln Glu Gly Arg Val 
    130                 135                 140                 


Pro Val Leu Arg Ser Cys Lys Val His Leu Ser Glu Lys Ser Leu Gln 
145                 150                 155                 160 


Ser Arg Glu Val Gly Lys Ala Leu Leu Ile Ser Ser Gly Val Leu Lys 
                165                 170                 175     


His Gln Val Thr His Thr Gly Glu Lys Ser His Arg Ser Ser Lys Ser 
            180                 185                 190         


Arg Glu Ala Phe His Ala Gly Lys Arg His Tyr Lys Cys Ser Glu Cys 
        195                 200                 205             


Gly Lys Ala Phe Gly Gln Lys Tyr Leu Leu Val Gln His Gln Arg Leu 
    210                 215                 220                 


His Ala Gly Lys Lys Thr Tyr Glu Cys Ser Glu Cys Gly Lys Leu Phe 
225                 230                 235                 240 


Arg Asp Met Ser Asn Leu Phe Ile His Gln Ile Val His Thr Gly Glu 
                245                 250                 255     


Arg Pro Tyr Gly Cys Ser Asn Cys Gly Lys Ser Phe Ser Arg Asn Ala 
            260                 265                 270         


His Leu Ile Glu His Gln Arg Val His Thr Gly Glu Lys Pro Phe Thr 
        275                 280                 285             


Cys Ser Glu Cys Gly Lys Ala Phe Arg His Asn Ser Thr Leu Val Gln 
    290                 295                 300                 


His His Lys Ile His Thr Gly Val Arg Pro Tyr Glu Cys Ser Glu Cys 
305                 310                 315                 320 


Gly Lys Leu Phe Ser Phe Asn Ser Ser Leu Met Lys His Gln Arg Ile 
                325                 330                 335     


His Thr Gly Glu Arg Pro Tyr Lys Cys Ser Glu Cys Gly Lys Phe Tyr 
            340                 345                 350         


Ser His Lys Ser Asn Leu Ile Lys His Trp Arg Val His Thr Gly Glu 
        355                 360                 365             


Arg Pro Tyr Lys Cys Ser Asp Cys Gly Lys Phe Phe Thr Gln Cys Ser 
    370                 375                 380                 


Ser Leu Met Gln His Gln Lys Val His Thr Gly Glu Lys Pro Phe Lys 
385                 390                 395                 400 


Cys Asn Glu Cys Gly Arg Phe Phe Arg Glu Asn Ser Thr Leu Val Arg 
                405                 410                 415     


His Gln Arg Val His Thr Gly Ala Lys Pro Tyr Glu Cys Arg Glu Cys 
            420                 425                 430         


Gly Lys Phe Phe Ser Gln Ser Ser Thr Leu Met Gln His Arg Lys Val 
        435                 440                 445             


His Ile Gly Glu Lys Pro Phe Lys Cys Asn Glu Cys Gly Arg Leu Phe 
    450                 455                 460                 


Arg Glu Asn Ser Ser Leu Val Lys His Gln Arg Val His Thr Gly Ala 
465                 470                 475                 480 


Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Phe Phe Arg His Asn Ser 
                485                 490                 495     


Ser Leu Phe Lys His Arg Arg Ile His Thr Gly Glu Met Gln 
            500                 505                 510 


<210>  79
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ala Ala Ala Ala Leu Arg Asp Pro Ala Gln Val Pro Val Ala Ala 
1               5                   10                  15      


Asp Leu Leu Thr Asp His Glu Glu Gln Gly Tyr Val Thr Phe Glu Asp 
            20                  25                  30          


Val Ala Val Tyr Phe Ser Gln Glu Glu Trp Arg Leu Leu Asp Asp Ala 
        35                  40                  45              


Gln Arg Leu Leu Tyr Arg Asn Val Met Leu Glu Asn Phe Thr Leu Leu 
    50                  55                  60                  


Ala Ser Leu Gly Cys Trp His Gly Ala Glu Ala Glu Glu Ala Pro Glu 
65                  70                  75                  80  


Gln Ile Ala Ser Val Gly Leu Leu Ser Ser Asn Ile Gln Gln His Gln 
                85                  90                  95      


Lys Gln His Cys Gly Glu Lys Pro Leu Lys Arg Gln Glu Gly Arg Val 
            100                 105                 110         


Pro Val Leu Arg Ser Cys Lys Val His Leu Ser Glu Lys Ser Leu Gln 
        115                 120                 125             


Ser Arg Glu Val Gly Lys Ala Leu Leu Ile Ser Ser Gly Val Leu Lys 
    130                 135                 140                 


His Gln Val Thr His Thr Gly Glu Lys Ser His Arg Ser Ser Lys Ser 
145                 150                 155                 160 


Arg Glu Ala Phe His Ala Gly Lys Arg His Tyr Lys Cys Ser Glu Cys 
                165                 170                 175     


Gly Lys Ala Phe Gly Gln Lys Tyr Leu Leu Val Gln His Gln Arg Leu 
            180                 185                 190         


His Ala Gly Lys Lys Thr Tyr Glu Cys Ser Glu Cys Gly Lys Leu Phe 
        195                 200                 205             


Arg Asp Met Ser Asn Leu Phe Ile His Gln Ile Val His Thr Gly Glu 
    210                 215                 220                 


Arg Pro Tyr Gly Cys Ser Asn Cys Gly Lys Ser Phe Ser Arg Asn Ala 
225                 230                 235                 240 


His Leu Ile Glu His Gln Arg Val His Thr Gly Glu Lys Pro Phe Thr 
                245                 250                 255     


Cys Ser Glu Cys Gly Lys Ala Phe Arg His Asn Ser Thr Leu Val Gln 
            260                 265                 270         


His His Lys Ile His Thr Gly Val Arg Pro Tyr Glu Cys Ser Glu Cys 
        275                 280                 285             


Gly Lys Leu Phe Ser Phe Asn Ser Ser Leu Met Lys His Gln Arg Ile 
    290                 295                 300                 


His Thr Gly Glu Arg Pro Tyr Lys Cys Ser Glu Cys Gly Lys Phe Tyr 
305                 310                 315                 320 


Ser His Lys Ser Asn Leu Ile Lys His Trp Arg Val His Thr Gly Glu 
                325                 330                 335     


Arg Pro Tyr Lys Cys Ser Asp Cys Gly Lys Phe Phe Thr Gln Cys Ser 
            340                 345                 350         


Ser Leu Met Gln His Gln Lys Val His Thr Gly Glu Lys Pro Phe Lys 
        355                 360                 365             


Cys Asn Glu Cys Gly Arg Phe Phe Arg Glu Asn Ser Thr Leu Val Arg 
    370                 375                 380                 


His Gln Arg Val His Thr Gly Ala Lys Pro Tyr Glu Cys Arg Glu Cys 
385                 390                 395                 400 


Gly Lys Phe Phe Ser Gln Ser Ser Thr Leu Met Gln His Arg Lys Val 
                405                 410                 415     


His Ile Gly Glu Lys Pro Phe Lys Cys Asn Glu Cys Gly Arg Leu Phe 
            420                 425                 430         


Arg Glu Asn Ser Ser Leu Val Lys His Gln Arg Val His Thr Gly Ala 
        435                 440                 445             


Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Phe Phe Arg His Asn Ser 
    450                 455                 460                 


Ser Leu Phe Lys His Arg Arg Ile His Thr Gly Glu Met Gln 
465                 470                 475             


<210>  80
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ala Ala Ala Ala Leu Arg Asp Pro Ala Gln Gly Tyr Val Thr Phe 
1               5                   10                  15      


Glu Asp Val Ala Val Tyr Phe Ser Gln Glu Glu Trp Arg Leu Leu Asp 
            20                  25                  30          


Asp Ala Gln Arg Leu Leu Tyr Arg Asn Val Met Leu Glu Asn Phe Thr 
        35                  40                  45              


Leu Leu Ala Ser Leu Gly Leu Ala Ser Ser Lys Thr His Glu Ile Thr 
    50                  55                  60                  


Gln Leu Glu Ser Trp Glu Glu Pro Phe Met Pro Ala Trp Glu Val Val 
65                  70                  75                  80  


Thr Ser Ala Ile Pro Arg Gly Cys Trp His Gly Ala Glu Ala Glu Glu 
                85                  90                  95      


Ala Pro Glu Gln Ile Ala Ser Val Gly Leu Leu Ser Ser Asn Ile Gln 
            100                 105                 110         


Gln His Gln Lys Gln His Cys Gly Glu Lys Pro Leu Lys Arg Gln Glu 
        115                 120                 125             


Gly Arg Val Pro Val Leu Arg Ser Cys Lys Val His Leu Ser Glu Lys 
    130                 135                 140                 


Ser Leu Gln Ser Arg Glu Val Gly Lys Ala Leu Leu Ile Ser Ser Gly 
145                 150                 155                 160 


Val Leu Lys His Gln Val Thr His Thr Gly Glu Lys Ser His Arg Ser 
                165                 170                 175     


Ser Lys Ser Arg Glu Ala Phe His Ala Gly Lys Arg His Tyr Lys Cys 
            180                 185                 190         


Ser Glu Cys Gly Lys Ala Phe Gly Gln Lys Tyr Leu Leu Val Gln His 
        195                 200                 205             


Gln Arg Leu His Ala Gly Lys Lys Thr Tyr Glu Cys Ser Glu Cys Gly 
    210                 215                 220                 


Lys Leu Phe Arg Asp Met Ser Asn Leu Phe Ile His Gln Ile Val His 
225                 230                 235                 240 


Thr Gly Glu Arg Pro Tyr Gly Cys Ser Asn Cys Gly Lys Ser Phe Ser 
                245                 250                 255     


Arg Asn Ala His Leu Ile Glu His Gln Arg Val His Thr Gly Glu Lys 
            260                 265                 270         


Pro Phe Thr Cys Ser Glu Cys Gly Lys Ala Phe Arg His Asn Ser Thr 
        275                 280                 285             


Leu Val Gln His His Lys Ile His Thr Gly Val Arg Pro Tyr Glu Cys 
    290                 295                 300                 


Ser Glu Cys Gly Lys Leu Phe Ser Phe Asn Ser Ser Leu Met Lys His 
305                 310                 315                 320 


Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Ser Glu Cys Gly 
                325                 330                 335     


Lys Phe Tyr Ser His Lys Ser Asn Leu Ile Lys His Trp Arg Val His 
            340                 345                 350         


Thr Gly Glu Arg Pro Tyr Lys Cys Ser Asp Cys Gly Lys Phe Phe Thr 
        355                 360                 365             


Gln Cys Ser Ser Leu Met Gln His Gln Lys Val His Thr Gly Glu Lys 
    370                 375                 380                 


Pro Phe Lys Cys Asn Glu Cys Gly Arg Phe Phe Arg Glu Asn Ser Thr 
385                 390                 395                 400 


Leu Val Arg His Gln Arg Val His Thr Gly Ala Lys Pro Tyr Glu Cys 
                405                 410                 415     


Arg Glu Cys Gly Lys Phe Phe Ser Gln Ser Ser Thr Leu Met Gln His 
            420                 425                 430         


Arg Lys Val His Ile Gly Glu Lys Pro Phe Lys Cys Asn Glu Cys Gly 
        435                 440                 445             


Arg Leu Phe Arg Glu Asn Ser Ser Leu Val Lys His Gln Arg Val His 
    450                 455                 460                 


Thr Gly Ala Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Phe Phe Arg 
465                 470                 475                 480 


His Asn Ser Ser Leu Phe Lys His Arg Arg Ile His Thr Gly Glu Met 
                485                 490                 495     


Gln 
    


<210>  81
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ala Ala Ala Ala Leu Arg Asp Pro Ala Gln Gln Gly Tyr Val Thr 
1               5                   10                  15      


Phe Glu Asp Val Ala Val Tyr Phe Ser Gln Glu Glu Trp Arg Leu Leu 
            20                  25                  30          


Asp Asp Ala Gln Arg Leu Leu Tyr Arg Asn Val Met Leu Glu Asn Phe 
        35                  40                  45              


Thr Leu Leu Ala Ser Leu Gly Leu Ala Ser Ser Lys Thr His Glu Ile 
    50                  55                  60                  


Thr Gln Leu Glu Ser Trp Glu Glu Pro Phe Met Pro Ala Trp Glu Val 
65                  70                  75                  80  


Val Thr Ser Ala Ile Pro Arg Gly Cys Trp His Gly Ala Glu Ala Glu 
                85                  90                  95      


Glu Ala Pro Glu Gln Ile Ala Ser Val Gly Leu Leu Ser Ser Asn Ile 
            100                 105                 110         


Gln Gln His Gln Lys Gln His Cys Gly Glu Lys Pro Leu Lys Arg Gln 
        115                 120                 125             


Glu Gly Arg Val Pro Val Leu Arg Ser Cys Lys Val His Leu Ser Glu 
    130                 135                 140                 


Lys Ser Leu Gln Ser Arg Glu Val Gly Lys Ala Leu Leu Ile Ser Ser 
145                 150                 155                 160 


Gly Val Leu Lys His Gln Val Thr His Thr Gly Glu Lys Ser His Arg 
                165                 170                 175     


Ser Ser Lys Ser Arg Glu Ala Phe His Ala Gly Lys Arg His Tyr Lys 
            180                 185                 190         


Cys Ser Glu Cys Gly Lys Ala Phe Gly Gln Lys Tyr Leu Leu Val Gln 
        195                 200                 205             


His Gln Arg Leu His Ala Gly Lys Lys Thr Tyr Glu Cys Ser Glu Cys 
    210                 215                 220                 


Gly Lys Leu Phe Arg Asp Met Ser Asn Leu Phe Ile His Gln Ile Val 
225                 230                 235                 240 


His Thr Gly Glu Arg Pro Tyr Gly Cys Ser Asn Cys Gly Lys Ser Phe 
                245                 250                 255     


Ser Arg Asn Ala His Leu Ile Glu His Gln Arg Val His Thr Gly Glu 
            260                 265                 270         


Lys Pro Phe Thr Cys Ser Glu Cys Gly Lys Ala Phe Arg His Asn Ser 
        275                 280                 285             


Thr Leu Val Gln His His Lys Ile His Thr Gly Val Arg Pro Tyr Glu 
    290                 295                 300                 


Cys Ser Glu Cys Gly Lys Leu Phe Ser Phe Asn Ser Ser Leu Met Lys 
305                 310                 315                 320 


His Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Ser Glu Cys 
                325                 330                 335     


Gly Lys Phe Tyr Ser His Lys Ser Asn Leu Ile Lys His Trp Arg Val 
            340                 345                 350         


His Thr Gly Glu Arg Pro Tyr Lys Cys Ser Asp Cys Gly Lys Phe Phe 
        355                 360                 365             


Thr Gln Cys Ser Ser Leu Met Gln His Gln Lys Val His Thr Gly Glu 
    370                 375                 380                 


Lys Pro Phe Lys Cys Asn Glu Cys Gly Arg Phe Phe Arg Glu Asn Ser 
385                 390                 395                 400 


Thr Leu Val Arg His Gln Arg Val His Thr Gly Ala Lys Pro Tyr Glu 
                405                 410                 415     


Cys Arg Glu Cys Gly Lys Phe Phe Ser Gln Ser Ser Thr Leu Met Gln 
            420                 425                 430         


His Arg Lys Val His Ile Gly Glu Lys Pro Phe Lys Cys Asn Glu Cys 
        435                 440                 445             


Gly Arg Leu Phe Arg Glu Asn Ser Ser Leu Val Lys His Gln Arg Val 
    450                 455                 460                 


His Thr Gly Ala Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Phe Phe 
465                 470                 475                 480 


Arg His Asn Ser Ser Leu Phe Lys His Arg Arg Ile His Thr Gly Glu 
                485                 490                 495     


Met Gln 
        


<210>  82
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Ala Ala Ala Ala Leu Arg Asp Pro Ala Gln Val Pro Val Ala Ala 
1               5                   10                  15      


Asp Leu Leu Thr Asp His Glu Glu Gln Gly Tyr Val Thr Phe Glu Asp 
            20                  25                  30          


Val Ala Val Tyr Phe Ser Gln Glu Glu Trp Arg Leu Leu Asp Asp Ala 
        35                  40                  45              


Gln Arg Leu Leu Tyr Arg Asn Val Met Leu Glu Asn Phe Thr Leu Leu 
    50                  55                  60                  


Ala Ser Leu Gly Leu Ala Ser Ser Lys Thr His Glu Ile Thr Gln Leu 
65                  70                  75                  80  


Glu Ser Trp Glu Glu Pro Phe Met Pro Ala Trp Glu Val Val Thr Ser 
                85                  90                  95      


Ala Ile Pro Arg Gly Cys Trp His Gly Ala Glu Ala Glu Glu Ala Pro 
            100                 105                 110         


Glu Gln Ile Ala Ser Val Gly Leu Leu Ser Ser Asn Ile Gln Gln His 
        115                 120                 125             


Gln Lys Gln His Cys Gly Glu Lys Pro Leu Lys Arg Gln Glu Gly Arg 
    130                 135                 140                 


Val Pro Val Leu Arg Ser Cys Lys Val His Leu Ser Glu Lys Ser Leu 
145                 150                 155                 160 


Gln Ser Arg Glu Val Gly Lys Ala Leu Leu Ile Ser Ser Gly Val Leu 
                165                 170                 175     


Lys His Gln Val Thr His Thr Gly Glu Lys Ser His Arg Ser Ser Lys 
            180                 185                 190         


Ser Arg Glu Ala Phe His Ala Gly Lys Arg His Tyr Lys Cys Ser Glu 
        195                 200                 205             


Cys Gly Lys Ala Phe Gly Gln Lys Tyr Leu Leu Val Gln His Gln Arg 
    210                 215                 220                 


Leu His Ala Gly Lys Lys Thr Tyr Glu Cys Ser Glu Cys Gly Lys Leu 
225                 230                 235                 240 


Phe Arg Asp Met Ser Asn Leu Phe Ile His Gln Ile Val His Thr Gly 
                245                 250                 255     


Glu Arg Pro Tyr Gly Cys Ser Asn Cys Gly Lys Ser Phe Ser Arg Asn 
            260                 265                 270         


Ala His Leu Ile Glu His Gln Arg Val His Thr Gly Glu Lys Pro Phe 
        275                 280                 285             


Thr Cys Ser Glu Cys Gly Lys Ala Phe Arg His Asn Ser Thr Leu Val 
    290                 295                 300                 


Gln His His Lys Ile His Thr Gly Val Arg Pro Tyr Glu Cys Ser Glu 
305                 310                 315                 320 


Cys Gly Lys Leu Phe Ser Phe Asn Ser Ser Leu Met Lys His Gln Arg 
                325                 330                 335     


Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Ser Glu Cys Gly Lys Phe 
            340                 345                 350         


Tyr Ser His Lys Ser Asn Leu Ile Lys His Trp Arg Val His Thr Gly 
        355                 360                 365             


Glu Arg Pro Tyr Lys Cys Ser Asp Cys Gly Lys Phe Phe Thr Gln Cys 
    370                 375                 380                 


Ser Ser Leu Met Gln His Gln Lys Val His Thr Gly Glu Lys Pro Phe 
385                 390                 395                 400 


Lys Cys Asn Glu Cys Gly Arg Phe Phe Arg Glu Asn Ser Thr Leu Val 
                405                 410                 415     


Arg His Gln Arg Val His Thr Gly Ala Lys Pro Tyr Glu Cys Arg Glu 
            420                 425                 430         


Cys Gly Lys Phe Phe Ser Gln Ser Ser Thr Leu Met Gln His Arg Lys 
        435                 440                 445             


Val His Ile Gly Glu Lys Pro Phe Lys Cys Asn Glu Cys Gly Arg Leu 
    450                 455                 460                 


Phe Arg Glu Asn Ser Ser Leu Val Lys His Gln Arg Val His Thr Gly 
465                 470                 475                 480 


Ala Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Phe Phe Arg His Asn 
                485                 490                 495     


Ser Ser Leu Phe Lys His Arg Arg Ile His Thr Gly Glu Met Gln 
            500                 505                 510     


<210>  83
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Ala Ala Ala Ala Leu Arg Asp Pro Ala Gln Gly Tyr Val Thr Phe 
1               5                   10                  15      


Glu Asp Val Ala Val Tyr Phe Ser Gln Glu Glu Trp Arg Leu Leu Asp 
            20                  25                  30          


Asp Ala Gln Arg Leu Leu Tyr Arg Asn Val Met Leu Glu Asn Phe Thr 
        35                  40                  45              


Leu Leu Ala Ser Leu Gly Cys Trp His Gly Ala Glu Ala Glu Glu Ala 
    50                  55                  60                  


Pro Glu Gln Ile Ala Ser Val Gly Leu Leu Ser Ser Asn Ile Gln Gln 
65                  70                  75                  80  


His Gln Lys Gln His Cys Gly Glu Lys Pro Leu Lys Arg Gln Glu Gly 
                85                  90                  95      


Arg Val Pro Val Leu Arg Ser Cys Lys Val His Leu Ser Glu Lys Ser 
            100                 105                 110         


Leu Gln Ser Arg Glu Val Gly Lys Ala Leu Leu Ile Ser Ser Gly Val 
        115                 120                 125             


Leu Lys His Gln Val Thr His Thr Gly Glu Lys Ser His Arg Ser Ser 
    130                 135                 140                 


Lys Ser Arg Glu Ala Phe His Ala Gly Lys Arg His Tyr Lys Cys Ser 
145                 150                 155                 160 


Glu Cys Gly Lys Ala Phe Gly Gln Lys Tyr Leu Leu Val Gln His Gln 
                165                 170                 175     


Arg Leu His Ala Gly Lys Lys Thr Tyr Glu Cys Ser Glu Cys Gly Lys 
            180                 185                 190         


Leu Phe Arg Asp Met Ser Asn Leu Phe Ile His Gln Ile Val His Thr 
        195                 200                 205             


Gly Glu Arg Pro Tyr Gly Cys Ser Asn Cys Gly Lys Ser Phe Ser Arg 
    210                 215                 220                 


Asn Ala His Leu Ile Glu His Gln Arg Val His Thr Gly Glu Lys Pro 
225                 230                 235                 240 


Phe Thr Cys Ser Glu Cys Gly Lys Ala Phe Arg His Asn Ser Thr Leu 
                245                 250                 255     


Val Gln His His Lys Ile His Thr Gly Val Arg Pro Tyr Glu Cys Ser 
            260                 265                 270         


Glu Cys Gly Lys Leu Phe Ser Phe Asn Ser Ser Leu Met Lys His Gln 
        275                 280                 285             


Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Ser Glu Cys Gly Lys 
    290                 295                 300                 


Phe Tyr Ser His Lys Ser Asn Leu Ile Lys His Trp Arg Val His Thr 
305                 310                 315                 320 


Gly Glu Arg Pro Tyr Lys Cys Ser Asp Cys Gly Lys Phe Phe Thr Gln 
                325                 330                 335     


Cys Ser Ser Leu Met Gln His Gln Lys Val His Thr Gly Glu Lys Pro 
            340                 345                 350         


Phe Lys Cys Asn Glu Cys Gly Arg Phe Phe Arg Glu Asn Ser Thr Leu 
        355                 360                 365             


Val Arg His Gln Arg Val His Thr Gly Ala Lys Pro Tyr Glu Cys Arg 
    370                 375                 380                 


Glu Cys Gly Lys Phe Phe Ser Gln Ser Ser Thr Leu Met Gln His Arg 
385                 390                 395                 400 


Lys Val His Ile Gly Glu Lys Pro Phe Lys Cys Asn Glu Cys Gly Arg 
                405                 410                 415     


Leu Phe Arg Glu Asn Ser Ser Leu Val Lys His Gln Arg Val His Thr 
            420                 425                 430         


Gly Ala Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys Phe Phe Arg His 
        435                 440                 445             


Asn Ser Ser Leu Phe Lys His Arg Arg Ile His Thr Gly Glu Met Gln 
    450                 455                 460                 


<210>  84
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ser Leu Gln Asp Ser Thr Leu Ser Arg Glu Gly Lys Pro Glu Gly 
1               5                   10                  15      


Glu Ile Met Ala Ala Val Phe Phe Ser Val Gly Arg Leu Ser Pro Glu 
            20                  25                  30          


Val Thr Gln Pro Asp Glu Asp Leu His Leu Gln Ala Glu Glu Thr Gln 
        35                  40                  45              


Leu Val Lys Glu Ser Val Thr Phe Lys Asp Val Ala Ile Asp Phe Thr 
    50                  55                  60                  


Leu Glu Glu Trp Arg Leu Met Asp Pro Thr Gln Arg Asn Leu His Lys 
65                  70                  75                  80  


Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Val Ser Leu Gly Leu Ala 
                85                  90                  95      


Val Ser Lys Pro Asp Met Ile Ser His Leu Glu Asn Gly Lys Gly Pro 
            100                 105                 110         


Trp Val Thr Val Arg Glu Ile Ser Arg Ile Pro Tyr Pro Asp Met Glu 
        115                 120                 125             


Pro Lys Pro Ala Thr Lys Lys Ala Thr Arg Thr Lys Ala Ile Ser Glu 
    130                 135                 140                 


Asp Leu Ser Gln Glu Ala Ile Leu Glu Lys Leu Thr Glu Asn Gly Leu 
145                 150                 155                 160 


Trp Asp Ser Arg Met Glu Gly Leu Trp Lys Trp Asn Asp Arg Ile Leu 
                165                 170                 175     


Arg Leu Gln Asn Asn Gln Glu Asn His Leu Ser Gln Arg Ile Ile Pro 
            180                 185                 190         


Leu Lys Lys Thr Pro Thr Ser Gln Arg Gly Phe Arg Phe Glu Ser Ile 
        195                 200                 205             


Leu Ile Pro Glu Pro Gly Ile Ala Thr Glu Glu Leu His Ser Arg Cys 
    210                 215                 220                 


Gln Thr Gln Glu Glu Asn Phe Thr Glu Asn Leu Asn Leu Ile Thr Asp 
225                 230                 235                 240 


Thr His Leu Gly Lys Ile Ile Cys Lys Glu Met Lys Gly Ser Lys Ala 
                245                 250                 255     


Ile Arg Gln Thr Ser Glu Leu Thr Leu Gly Lys Lys Ser Asn Asn Lys 
            260                 265                 270         


Glu Lys Pro Tyr Lys Cys Ser Thr Cys Glu Lys Ala Phe His Tyr Arg 
        275                 280                 285             


Ser Leu Leu Ile Gln His Gln Arg Thr His Thr Lys Glu Lys Pro Tyr 
    290                 295                 300                 


Glu Cys Asn Glu Cys Gly Lys Thr Phe Ser Gln Pro Ser Tyr Leu Ser 
305                 310                 315                 320 


Gln His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu 
                325                 330                 335     


Cys Gly Lys Ala Phe Ile Ala Ser Ser Ser Leu Met Val His Gln Arg 
            340                 345                 350         


Ile His Thr Lys Glu Lys Pro Tyr Gln Cys Asn Val Cys Gly Lys Ser 
        355                 360                 365             


Phe Ser Gln Cys Ala Arg Leu Asn Gln His Gln Arg Ile Gln Thr Gly 
    370                 375                 380                 


Glu Lys Pro Tyr Lys Cys Ser Glu Cys Gly Lys Ala Phe Ser Asp Lys 
385                 390                 395                 400 


Ser Lys Leu Ala Arg His Gln Glu Thr His Asn Gly Glu Lys Pro Tyr 
                405                 410                 415     


Lys Cys Asp Asp Cys Gly Lys Ala Phe Arg Asn Lys Ser Tyr Leu Ser 
            420                 425                 430         


Val His Gln Lys Thr His Thr Glu Glu Lys Pro Tyr Gln Cys Asn Glu 
        435                 440                 445             


Cys Gly Lys Ser Phe Lys Asn Thr Thr Ile Phe Asn Val His Gln Arg 
    450                 455                 460                 


Ile His Thr Gly Glu Lys Pro Phe Arg Cys Asn Glu Cys Gly Lys Ala 
465                 470                 475                 480 


Tyr Arg Ser Asn Ser Ser Leu Ile Val His Ile Arg Thr His Thr Gly 
                485                 490                 495     


Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Asn Arg Ile 
            500                 505                 510         


Ala Asn Phe Thr Glu His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr 
        515                 520                 525             


Lys Cys Asn Glu Cys Gly Lys Ala Phe Ile Asn Tyr Ser Cys Leu Thr 
    530                 535                 540                 


Val His His Arg Met His Thr Gly Glu Lys Pro Tyr Lys Cys Thr Glu 
545                 550                 555                 560 


Cys Gly Lys Ala Phe Met Arg Ser Ser Ser Leu Ile Ile His Gln Arg 
                565                 570                 575     


Ile His Thr Glu Glu Lys Pro Tyr Leu Cys Asn Glu Cys Gly Glu Ser 
            580                 585                 590         


Phe Arg Ile Lys Ser His Leu Thr Val His Gln Arg Ile His Thr Gly 
        595                 600                 605             


Glu Lys Pro Tyr Lys Cys Thr Asp Cys Glu Arg Ala Phe Thr Lys Met 
    610                 615                 620                 


Val Asn Leu Lys Glu His Gln Lys Ile His Thr Gly Val Lys Pro Tyr 
625                 630                 635                 640 


Lys Cys Tyr Asp Cys Gly Lys Ser Phe Arg Thr Lys Ser Tyr Leu Ile 
                645                 650                 655     


Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu 
            660                 665                 670         


Cys Glu Lys Ala Phe Thr Asn Thr Ser Gln Leu Thr Val His Gln Arg 
        675                 680                 685             


Arg His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Val 
    690                 695                 700                 


Phe Thr Ser Asn Ser Gly Phe Asn Thr His Gln Arg Thr His Thr Gly 
705                 710                 715                 720 


Glu Lys Pro Phe Lys Cys Asn Asp Cys Gly Lys Ala Phe Ser Gln Met 
                725                 730                 735     


Val His Val Thr Glu His Gln Lys Ile His Ser Gly Glu Lys Pro Tyr 
            740                 745                 750         


Lys Cys Asp Val Cys Gly Lys Ala Phe Arg Arg Gly Ser Tyr Leu Thr 
        755                 760                 765             


Val His Trp Arg Thr His Thr Gly Glu Lys Pro Tyr Thr Cys Lys Glu 
    770                 775                 780                 


Cys Gly Lys Gly Cys Ile Thr Leu Ser Gln Leu Thr Leu His Gln Arg 
785                 790                 795                 800 


Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala 
                805                 810                 815     


Phe Arg Thr Asn Ser Asp Phe Thr Val His Leu Arg Met His Thr Gly 
            820                 825                 830         


Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Arg Ser Ser 
        835                 840                 845             


Ser Ser Leu Thr Val His Gln Arg Ile His Gln Arg Glu Thr Gln Leu 
    850                 855                 860                 


Ile 
865 


<210>  85
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Glu Pro Lys Pro Ala Thr Lys Lys Ala Thr Arg Thr Lys Ala Ile 
1               5                   10                  15      


Ser Glu Asp Leu Ser Gln Glu Ala Ile Leu Glu Lys Leu Thr Glu Asn 
            20                  25                  30          


Gly Leu Trp Asp Ser Arg Met Glu Gly Leu Trp Lys Trp Asn Asp Arg 
        35                  40                  45              


Ile Leu Arg Leu Gln Asn Asn Gln Glu Asn His Leu Ser Gln Arg Ile 
    50                  55                  60                  


Ile Pro Leu Lys Lys Thr Pro Thr Ser Gln Arg Gly Phe Arg Phe Glu 
65                  70                  75                  80  


Ser Ile Leu Ile Pro Glu Pro Gly Ile Ala Thr Glu Glu Leu His Ser 
                85                  90                  95      


Arg Cys Gln Thr Gln Glu Glu Asn Phe Thr Glu Asn Leu Asn Leu Ile 
            100                 105                 110         


Thr Asp Thr His Leu Gly Lys Ile Ile Cys Lys Glu Met Lys Gly Ser 
        115                 120                 125             


Lys Ala Ile Arg Gln Thr Ser Glu Leu Thr Leu Gly Lys Lys Ser Asn 
    130                 135                 140                 


Asn Lys Glu Lys Pro Tyr Lys Cys Ser Thr Cys Glu Lys Ala Phe His 
145                 150                 155                 160 


Tyr Arg Ser Leu Leu Ile Gln His Gln Arg Thr His Thr Lys Glu Lys 
                165                 170                 175     


Pro Tyr Glu Cys Asn Glu Cys Gly Lys Thr Phe Ser Gln Pro Ser Tyr 
            180                 185                 190         


Leu Ser Gln His Lys Lys Ile His Thr Gly Glu Lys Pro Tyr Lys Cys 
        195                 200                 205             


Asn Glu Cys Gly Lys Ala Phe Ile Ala Ser Ser Ser Leu Met Val His 
    210                 215                 220                 


Gln Arg Ile His Thr Lys Glu Lys Pro Tyr Gln Cys Asn Val Cys Gly 
225                 230                 235                 240 


Lys Ser Phe Ser Gln Cys Ala Arg Leu Asn Gln His Gln Arg Ile Gln 
                245                 250                 255     


Thr Gly Glu Lys Pro Tyr Lys Cys Ser Glu Cys Gly Lys Ala Phe Ser 
            260                 265                 270         


Asp Lys Ser Lys Leu Ala Arg His Gln Glu Thr His Asn Gly Glu Lys 
        275                 280                 285             


Pro Tyr Lys Cys Asp Asp Cys Gly Lys Ala Phe Arg Asn Lys Ser Tyr 
    290                 295                 300                 


Leu Ser Val His Gln Lys Thr His Thr Glu Glu Lys Pro Tyr Gln Cys 
305                 310                 315                 320 


Asn Glu Cys Gly Lys Ser Phe Lys Asn Thr Thr Ile Phe Asn Val His 
                325                 330                 335     


Gln Arg Ile His Thr Gly Glu Lys Pro Phe Arg Cys Asn Glu Cys Gly 
            340                 345                 350         


Lys Ala Tyr Arg Ser Asn Ser Ser Leu Ile Val His Ile Arg Thr His 
        355                 360                 365             


Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Phe Asn 
    370                 375                 380                 


Arg Ile Ala Asn Phe Thr Glu His Gln Arg Ile His Thr Gly Glu Lys 
385                 390                 395                 400 


Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ile Asn Tyr Ser Cys 
                405                 410                 415     


Leu Thr Val His His Arg Met His Thr Gly Glu Lys Pro Tyr Lys Cys 
            420                 425                 430         


Thr Glu Cys Gly Lys Ala Phe Met Arg Ser Ser Ser Leu Ile Ile His 
        435                 440                 445             


Gln Arg Ile His Thr Glu Glu Lys Pro Tyr Leu Cys Asn Glu Cys Gly 
    450                 455                 460                 


Glu Ser Phe Arg Ile Lys Ser His Leu Thr Val His Gln Arg Ile His 
465                 470                 475                 480 


Thr Gly Glu Lys Pro Tyr Lys Cys Thr Asp Cys Glu Arg Ala Phe Thr 
                485                 490                 495     


Lys Met Val Asn Leu Lys Glu His Gln Lys Ile His Thr Gly Val Lys 
            500                 505                 510         


Pro Tyr Lys Cys Tyr Asp Cys Gly Lys Ser Phe Arg Thr Lys Ser Tyr 
        515                 520                 525             


Leu Ile Val His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
    530                 535                 540                 


Asn Glu Cys Glu Lys Ala Phe Thr Asn Thr Ser Gln Leu Thr Val His 
545                 550                 555                 560 


Gln Arg Arg His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly 
                565                 570                 575     


Lys Val Phe Thr Ser Asn Ser Gly Phe Asn Thr His Gln Arg Thr His 
            580                 585                 590         


Thr Gly Glu Lys Pro Phe Lys Cys Asn Asp Cys Gly Lys Ala Phe Ser 
        595                 600                 605             


Gln Met Val His Val Thr Glu His Gln Lys Ile His Ser Gly Glu Lys 
    610                 615                 620                 


Pro Tyr Lys Cys Asp Val Cys Gly Lys Ala Phe Arg Arg Gly Ser Tyr 
625                 630                 635                 640 


Leu Thr Val His Trp Arg Thr His Thr Gly Glu Lys Pro Tyr Thr Cys 
                645                 650                 655     


Lys Glu Cys Gly Lys Gly Cys Ile Thr Leu Ser Gln Leu Thr Leu His 
            660                 665                 670         


Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Glu Glu Cys Gly 
        675                 680                 685             


Lys Ala Phe Arg Thr Asn Ser Asp Phe Thr Val His Leu Arg Met His 
    690                 695                 700                 


Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Arg 
705                 710                 715                 720 


Ser Ser Ser Ser Leu Thr Val His Gln Arg Ile His Gln Arg Glu Thr 
                725                 730                 735     


Gln Leu Ile 
            


<210>  86
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ala Leu Ser Gln Gly Leu Phe Thr Phe Lys Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Gln Glu Glu Trp Glu Cys Leu Asp Pro Ala Gln Arg Ala Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Leu Ser Leu Asp 
        35                  40                  45              


Glu Asp Asn Ile Pro Pro Glu Asp Asp Ile Ser Val Gly Phe Thr Ser 
    50                  55                  60                  


Lys Gly Leu Ser Pro Lys Glu Asn Asn Lys Glu Glu Leu Tyr His Leu 
65                  70                  75                  80  


Val Ile Leu Glu Arg Lys Glu Ser His Gly Ile Asn Asn Phe Asp Leu 
                85                  90                  95      


Lys Glu Val Trp Glu Asn Met Pro Lys Phe Asp Ser Leu Trp Asp Tyr 
            100                 105                 110         


Asp Val Lys Asn Tyr Lys Gly Met Pro Leu Thr Cys Asn Lys Asn Leu 
        115                 120                 125             


Thr His Arg Lys Asp Gln Gln His Asn Lys Ser Ser Ile His Phe Ser 
    130                 135                 140                 


Leu Lys Gln Ser Val Ser Ile Arg Asp Ser Ala His Gln Tyr Phe Ile 
145                 150                 155                 160 


His Asp Lys Pro Phe Ile Arg Asn Leu Leu Lys Leu Lys Asn Asn Ile 
                165                 170                 175     


Arg Tyr Ala Gly Asn Lys Tyr Val Lys Cys Phe Glu Asn Lys Ile Gly 
            180                 185                 190         


Leu Ser Leu Gln Ala Gln Leu Ala Glu Leu Gln Arg Phe Gln Thr Gly 
        195                 200                 205             


Glu Lys Met Tyr Glu Cys Asn Pro Val Glu Lys Ser Ile Asn Ser Ser 
    210                 215                 220                 


Ser Val Ser Pro Leu Pro Pro Cys Val Lys Asn Ile Cys Asn Lys Tyr 
225                 230                 235                 240 


Arg Lys Ile Leu Lys Tyr Pro Leu Leu His Thr Gln Tyr Gly Arg Thr 
                245                 250                 255     


His Ile Arg Glu Lys Ser Tyr Lys Cys Asn Asp Cys Gly Lys Ala Phe 
            260                 265                 270         


Ser Lys Ser Ser Asn Leu Thr Asn His Gln Arg Ile His Ser Gly Gln 
        275                 280                 285             


Arg Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Asn Gln Cys Ser 
    290                 295                 300                 


Asn Leu Thr Arg His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Gln 
305                 310                 315                 320 


Cys Asn Ile Cys Gly Lys Val Cys Ser Gln Asn Ser Asn Leu Ala Ser 
                325                 330                 335     


His Gln Arg Met His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys 
            340                 345                 350         


Gly Lys Ala Phe Ile Gln Arg Ser His Leu Trp Gly His Glu Arg Ile 
        355                 360                 365             


His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Asp Lys Ala Phe 
    370                 375                 380                 


Ala Glu Arg Ser Ser Leu Thr Gln His Lys Arg Ile His Thr Gly Glu 
385                 390                 395                 400 


Lys Pro Tyr Ile Cys Asn Glu Cys Gly Lys Ala Phe Lys Gln Cys Ser 
                405                 410                 415     


His Leu Thr Arg His Gln Asn Ile His Pro Gly Glu Lys Pro His Lys 
            420                 425                 430         


Cys Asn Val Cys Gly Arg Ala Phe Ile Gln Ser Ser Ser Leu Val Glu 
        435                 440                 445             


His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asn Lys Cys 
    450                 455                 460                 


Asp Lys Ala Phe Ile Lys Arg Ser His Leu Trp Gly His Gln Arg Thr 
465                 470                 475                 480 


His Thr Gly Glu Lys Pro Tyr Lys Cys Thr Glu Cys Gly Lys Ala Phe 
                485                 490                 495     


Thr Glu Arg Ser Asn Leu Thr Gln His Lys Lys Ile His Thr Gly Glu 
            500                 505                 510         


Lys Pro Tyr Lys Cys Thr Glu Cys Gly Lys Ala Phe Thr Gln Phe Ala 
        515                 520                 525             


Asn Leu Thr Arg His Gln Lys Ile His Ile Glu Lys Lys His Cys Lys 
    530                 535                 540                 


His Asn Ile His Gly Asn Ala Leu Phe Gln Ser Ser Asn Leu Gly Asp 
545                 550                 555                 560 


His Gln Lys Ser Tyr Asn Arg Glu Lys His Ile Lys Tyr Asn Glu Thr 
                565                 570                 575     


Lys Ile Lys Tyr Ser Ser Cys Thr 
            580                 


<210>  87
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Gly Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Arg Glu 
1               5                   10                  15      


Glu Trp Glu His Leu Asp Ser Asp Gln Lys Leu Leu Tyr Gly Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Gly Asn Leu Val Ser Leu Gly Leu Ala Val Ser 
        35                  40                  45              


Lys Pro Asp Leu Ile Thr Phe Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Ser Ala Glu Thr Val Ala Ile Gln Pro Asp Ile Phe Ser His 
65                  70                  75                  80  


Asp Thr Gln Gly Leu Leu Arg Lys Lys Leu Ile Glu Ala Ser Phe Gln 
                85                  90                  95      


Lys Val Ile Leu Asp Gly Tyr Gly Ser Cys Gly Pro Gln Asn Leu Asn 
            100                 105                 110         


Leu Arg Lys Glu Trp Glu Ser Glu Gly Lys Ile Ile Leu Trp 
        115                 120                 125     


<210>  88
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Val Asn Val Pro Asp Ile Phe Ser His Asp Thr Gln Gly Leu Leu 
1               5                   10                  15      


Arg Lys Lys Leu Ile Glu Ala Ser Phe Gln Lys Val Ile Leu Asp Gly 
            20                  25                  30          


Tyr Gly Ser Cys Gly Pro Gln Asn Leu Asn Leu Arg Lys Glu Trp Glu 
        35                  40                  45              


Ser Glu Gly Lys Cys Glu Gly His Asn Gly Tyr Tyr Asp Gly His Thr 
    50                  55                  60                  


Lys Cys Lys Thr Thr Thr Tyr Asn Lys Asn Leu Thr Val Thr Gly Gly 
65                  70                  75                  80  


Gln Lys His Glu Lys Thr Gln Phe Met Ser Val Ala Phe Ser Lys Pro 
                85                  90                  95      


Cys Val Ser Val Ser Lys Cys Gln His Gln Phe Leu Lys Leu Thr Phe 
            100                 105                 110         


Ser Phe Lys Gly Asn Leu Asp Asn Pro Asn Ser Asp Leu Val His Val 
        115                 120                 125             


Ser Asn Asn His Leu Asn Gln Leu Lys Tyr Arg Thr Gly Val Asn Val 
    130                 135                 140                 


Gln Ser Asn Ile Ser Glu Lys Glu Arg Phe Lys Asn Glu Glu Val Ile 
145                 150                 155                 160 


Ser Lys Tyr Asp Gln Phe Asp Gly Ser Leu Leu Lys Val Cys Phe Thr 
                165                 170                 175     


Asn Lys 
        


<210>  89
<211>  4548
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Ala Ala Pro Glu Gln Ser His Val Val Gln Asp Cys Tyr His Gly Asp 
            20                  25                  30          


Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr 
        35                  40                  45              


Cys Gln Ala Trp Ser Ser Met Thr Pro His Gln His Asn Arg Thr Thr 
    50                  55                  60                  


Glu Asn Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro 
65                  70                  75                  80  


Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg 
                85                  90                  95      


Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala 
            100                 105                 110         


Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser 
        115                 120                 125             


Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His 
    130                 135                 140                 


Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly 
145                 150                 155                 160 


Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg 
                165                 170                 175     


Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg 
            180                 185                 190         


Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly 
        195                 200                 205             


Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly 
    210                 215                 220                 


Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala 
225                 230                 235                 240 


Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys 
                245                 250                 255     


Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val 
            260                 265                 270         


Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His 
        275                 280                 285             


Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr 
    290                 295                 300                 


Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp 
305                 310                 315                 320 


Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala 
                325                 330                 335     


Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro Ser Leu 
            340                 345                 350         


Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly Val Gln 
        355                 360                 365             


Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr 
    370                 375                 380                 


Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr Pro His 
385                 390                 395                 400 


Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met 
                405                 410                 415     


Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys Tyr Thr 
            420                 425                 430         


Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln Cys Ser 
        435                 440                 445             


Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro Val Pro 
    450                 455                 460                 


Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg Pro Gly 
465                 470                 475                 480 


Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly Thr Tyr 
                485                 490                 495     


Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser Met Thr 
            500                 505                 510         


Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala Gly Leu 
        515                 520                 525             


Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro Tyr Cys 
    530                 535                 540                 


Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu Thr Gln 
545                 550                 555                 560 


Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val Thr Pro 
                565                 570                 575     


Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu Gln Arg 
            580                 585                 590         


Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr Arg Gly 
        595                 600                 605             


Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp Ser Ser 
    610                 615                 620                 


Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro Asn Ala 
625                 630                 635                 640 


Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala Ala Pro 
                645                 650                 655     


Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys Asn Leu 
            660                 665                 670         


Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro Thr Val 
        675                 680                 685             


Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro Thr Glu 
    690                 695                 700                 


Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln Ser Tyr 
705                 710                 715                 720 


Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln Ala Trp 
                725                 730                 735     


Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr Tyr Pro 
            740                 745                 750         


Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala Val Ala 
        755                 760                 765             


Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu Tyr Cys 
    770                 775                 780                 


Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala Pro Pro 
785                 790                 795                 800 


Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln Ala Pro 
                805                 810                 815     


Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn Gly Gln 
            820                 825                 830         


Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr Cys Gln 
        835                 840                 845             


Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro Glu Tyr 
    850                 855                 860                 


Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro Asp Ala 
865                 870                 875                 880 


Val Ala Ala Pro Tyr Cys Tyr Thr Arg Asp Pro Gly Val Arg Trp Glu 
                885                 890                 895     


Tyr Cys Asn Leu Thr Gln Cys Ser Asp Ala Glu Gly Thr Ala Val Ala 
            900                 905                 910         


Pro Pro Thr Val Thr Pro Val Pro Ser Leu Glu Ala Pro Ser Glu Gln 
        915                 920                 925             


Ala Pro Thr Glu Gln Arg Pro Gly Val Gln Glu Cys Tyr His Gly Asn 
    930                 935                 940                 


Gly Gln Ser Tyr Arg Gly Thr Tyr Ser Thr Thr Val Thr Gly Arg Thr 
945                 950                 955                 960 


Cys Gln Ala Trp Ser Ser Met Thr Pro His Ser His Ser Arg Thr Pro 
                965                 970                 975     


Glu Tyr Tyr Pro Asn Ala Gly Leu Ile Met Asn Tyr Cys Arg Asn Pro 
            980                 985                 990         


Asp Ala Val Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 
        995                 1000                 1005             


Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 
    1010                 1015                 1020             


Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 
    1025                 1030                 1035             


Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 
    1040                 1045                 1050             


Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    1055                 1060                 1065             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    1070                 1075                 1080             


His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 
    1085                 1090                 1095             


Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 
    1100                 1105                 1110             


Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 
    1115                 1120                 1125             


Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 
    1130                 1135                 1140             


Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 
    1145                 1150                 1155             


Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 
    1160                 1165                 1170             


Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 
    1175                 1180                 1185             


Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 
    1190                 1195                 1200             


Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 
    1205                 1210                 1215             


Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 
    1220                 1225                 1230             


Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 
    1235                 1240                 1245             


Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 
    1250                 1255                 1260             


Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 
    1265                 1270                 1275             


Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 
    1280                 1285                 1290             


Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 
    1295                 1300                 1305             


Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 
    1310                 1315                 1320             


Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 
    1325                 1330                 1335             


Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 
    1340                 1345                 1350             


Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 
    1355                 1360                 1365             


Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 
    1370                 1375                 1380             


Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 
    1385                 1390                 1395             


Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 
    1400                 1405                 1410             


Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 
    1415                 1420                 1425             


Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 
    1430                 1435                 1440             


Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 
    1445                 1450                 1455             


Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 
    1460                 1465                 1470             


Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 
    1475                 1480                 1485             


Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 
    1490                 1495                 1500             


Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 
    1505                 1510                 1515             


Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 
    1520                 1525                 1530             


Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 
    1535                 1540                 1545             


Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 
    1550                 1555                 1560             


Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 
    1565                 1570                 1575             


Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 
    1580                 1585                 1590             


Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 
    1595                 1600                 1605             


Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 
    1610                 1615                 1620             


Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    1625                 1630                 1635             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    1640                 1645                 1650             


His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 
    1655                 1660                 1665             


Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 
    1670                 1675                 1680             


Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 
    1685                 1690                 1695             


Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 
    1700                 1705                 1710             


Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 
    1715                 1720                 1725             


Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 
    1730                 1735                 1740             


Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 
    1745                 1750                 1755             


Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 
    1760                 1765                 1770             


Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 
    1775                 1780                 1785             


Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 
    1790                 1795                 1800             


Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 
    1805                 1810                 1815             


Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 
    1820                 1825                 1830             


Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 
    1835                 1840                 1845             


Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 
    1850                 1855                 1860             


Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 
    1865                 1870                 1875             


Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 
    1880                 1885                 1890             


Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 
    1895                 1900                 1905             


Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 
    1910                 1915                 1920             


Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 
    1925                 1930                 1935             


Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 
    1940                 1945                 1950             


Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 
    1955                 1960                 1965             


Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 
    1970                 1975                 1980             


Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 
    1985                 1990                 1995             


Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 
    2000                 2005                 2010             


Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 
    2015                 2020                 2025             


Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 
    2030                 2035                 2040             


Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 
    2045                 2050                 2055             


Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 
    2060                 2065                 2070             


Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 
    2075                 2080                 2085             


Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 
    2090                 2095                 2100             


Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 
    2105                 2110                 2115             


Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 
    2120                 2125                 2130             


Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 
    2135                 2140                 2145             


Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 
    2150                 2155                 2160             


Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 
    2165                 2170                 2175             


Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 
    2180                 2185                 2190             


Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    2195                 2200                 2205             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    2210                 2215                 2220             


His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 
    2225                 2230                 2235             


Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 
    2240                 2245                 2250             


Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 
    2255                 2260                 2265             


Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 
    2270                 2275                 2280             


Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 
    2285                 2290                 2295             


Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 
    2300                 2305                 2310             


Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 
    2315                 2320                 2325             


Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 
    2330                 2335                 2340             


Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 
    2345                 2350                 2355             


Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 
    2360                 2365                 2370             


Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 
    2375                 2380                 2385             


Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 
    2390                 2395                 2400             


Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 
    2405                 2410                 2415             


Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 
    2420                 2425                 2430             


Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 
    2435                 2440                 2445             


Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 
    2450                 2455                 2460             


Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 
    2465                 2470                 2475             


Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 
    2480                 2485                 2490             


Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 
    2495                 2500                 2505             


Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 
    2510                 2515                 2520             


Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 
    2525                 2530                 2535             


Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 
    2540                 2545                 2550             


Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 
    2555                 2560                 2565             


Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 
    2570                 2575                 2580             


Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 
    2585                 2590                 2595             


Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 
    2600                 2605                 2610             


Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 
    2615                 2620                 2625             


Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 
    2630                 2635                 2640             


Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 
    2645                 2650                 2655             


Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 
    2660                 2665                 2670             


Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 
    2675                 2680                 2685             


Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 
    2690                 2695                 2700             


Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 
    2705                 2710                 2715             


Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 
    2720                 2725                 2730             


Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 
    2735                 2740                 2745             


Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 
    2750                 2755                 2760             


Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    2765                 2770                 2775             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    2780                 2785                 2790             


His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 
    2795                 2800                 2805             


Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Ala Val Ala  Ala Pro Tyr 
    2810                 2815                 2820             


Cys Tyr  Thr Arg Asp Pro Gly  Val Arg Trp Glu Tyr  Cys Asn Leu 
    2825                 2830                 2835             


Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 
    2840                 2845                 2850             


Val Thr  Pro Val Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 
    2855                 2860                 2865             


Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 
    2870                 2875                 2880             


Gln Ser  Tyr Arg Gly Thr Tyr  Ser Thr Thr Val Thr  Gly Arg Thr 
    2885                 2890                 2895             


Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 
    2900                 2905                 2910             


Pro Glu  Tyr Tyr Pro Asn Ala  Gly Leu Ile Met Asn  Tyr Cys Arg 
    2915                 2920                 2925             


Asn Pro  Asp Ala Val Ala Ala  Pro Tyr Cys Tyr Thr  Arg Asp Pro 
    2930                 2935                 2940             


Gly Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Gln Cys  Ser Asp Ala 
    2945                 2950                 2955             


Glu Gly  Thr Ala Val Ala Pro  Pro Thr Val Thr Pro  Val Pro Ser 
    2960                 2965                 2970             


Leu Glu  Ala Pro Ser Glu Gln  Ala Pro Thr Glu Gln  Arg Pro Gly 
    2975                 2980                 2985             


Val Gln  Glu Cys Tyr His Gly  Asn Gly Gln Ser Tyr  Arg Gly Thr 
    2990                 2995                 3000             


Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 
    3005                 3010                 3015             


Met Thr  Pro His Ser His Ser  Arg Thr Pro Glu Tyr  Tyr Pro Asn 
    3020                 3025                 3030             


Ala Gly  Leu Ile Met Asn Tyr  Cys Arg Asn Pro Asp  Ala Val Ala 
    3035                 3040                 3045             


Ala Pro  Tyr Cys Tyr Thr Arg  Asp Pro Gly Val Arg  Trp Glu Tyr 
    3050                 3055                 3060             


Cys Asn  Leu Thr Gln Cys Ser  Asp Ala Glu Gly Thr  Ala Val Ala 
    3065                 3070                 3075             


Pro Pro  Thr Val Thr Pro Val  Pro Ser Leu Glu Ala  Pro Ser Glu 
    3080                 3085                 3090             


Gln Ala  Pro Thr Glu Gln Arg  Pro Gly Val Gln Glu  Cys Tyr His 
    3095                 3100                 3105             


Gly Asn  Gly Gln Ser Tyr Arg  Gly Thr Tyr Ser Thr  Thr Val Thr 
    3110                 3115                 3120             


Gly Arg  Thr Cys Gln Ala Trp  Ser Ser Met Thr Pro  His Ser His 
    3125                 3130                 3135             


Ser Arg  Thr Pro Glu Tyr Tyr  Pro Asn Ala Gly Leu  Ile Met Asn 
    3140                 3145                 3150             


Tyr Cys  Arg Asn Pro Asp Ala  Val Ala Ala Pro Tyr  Cys Tyr Thr 
    3155                 3160                 3165             


Arg Asp  Pro Gly Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 
    3170                 3175                 3180             


Ser Asp  Ala Glu Gly Thr Ala  Val Ala Pro Pro Thr  Val Thr Pro 
    3185                 3190                 3195             


Val Pro  Ser Leu Glu Ala Pro  Ser Glu Gln Ala Pro  Thr Glu Gln 
    3200                 3205                 3210             


Arg Pro  Gly Val Gln Glu Cys  Tyr His Gly Asn Gly  Gln Ser Tyr 
    3215                 3220                 3225             


Arg Gly  Thr Tyr Ser Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ala 
    3230                 3235                 3240             


Trp Ser  Ser Met Thr Pro His  Ser His Ser Arg Thr  Pro Glu Tyr 
    3245                 3250                 3255             


Tyr Pro  Asn Ala Gly Leu Ile  Met Asn Tyr Cys Arg  Asn Pro Asp 
    3260                 3265                 3270             


Ala Val  Ala Ala Pro Tyr Cys  Tyr Thr Arg Asp Pro  Gly Val Arg 
    3275                 3280                 3285             


Trp Glu  Tyr Cys Asn Leu Thr  Gln Cys Ser Asp Ala  Glu Gly Thr 
    3290                 3295                 3300             


Ala Val  Ala Pro Pro Thr Val  Thr Pro Val Pro Ser  Leu Glu Ala 
    3305                 3310                 3315             


Pro Ser  Glu Gln Ala Pro Thr  Glu Gln Arg Pro Gly  Val Gln Glu 
    3320                 3325                 3330             


Cys Tyr  His Gly Asn Gly Gln  Ser Tyr Arg Gly Thr  Tyr Ser Thr 
    3335                 3340                 3345             


Thr Val  Thr Gly Arg Thr Cys  Gln Ala Trp Ser Ser  Met Thr Pro 
    3350                 3355                 3360             


His Ser  His Ser Arg Thr Pro  Glu Tyr Tyr Pro Asn  Ala Gly Leu 
    3365                 3370                 3375             


Ile Met  Asn Tyr Cys Arg Asn  Pro Asp Pro Val Ala  Ala Pro Tyr 
    3380                 3385                 3390             


Cys Tyr  Thr Arg Asp Pro Ser  Val Arg Trp Glu Tyr  Cys Asn Leu 
    3395                 3400                 3405             


Thr Gln  Cys Ser Asp Ala Glu  Gly Thr Ala Val Ala  Pro Pro Thr 
    3410                 3415                 3420             


Ile Thr  Pro Ile Pro Ser Leu  Glu Ala Pro Ser Glu  Gln Ala Pro 
    3425                 3430                 3435             


Thr Glu  Gln Arg Pro Gly Val  Gln Glu Cys Tyr His  Gly Asn Gly 
    3440                 3445                 3450             


Gln Ser  Tyr Gln Gly Thr Tyr  Phe Ile Thr Val Thr  Gly Arg Thr 
    3455                 3460                 3465             


Cys Gln  Ala Trp Ser Ser Met  Thr Pro His Ser His  Ser Arg Thr 
    3470                 3475                 3480             


Pro Ala  Tyr Tyr Pro Asn Ala  Gly Leu Ile Lys Asn  Tyr Cys Arg 
    3485                 3490                 3495             


Asn Pro  Asp Pro Val Ala Ala  Pro Trp Cys Tyr Thr  Thr Asp Pro 
    3500                 3505                 3510             


Ser Val  Arg Trp Glu Tyr Cys  Asn Leu Thr Arg Cys  Ser Asp Ala 
    3515                 3520                 3525             


Glu Trp  Thr Ala Phe Val Pro  Pro Asn Val Ile Leu  Ala Pro Ser 
    3530                 3535                 3540             


Leu Glu  Ala Phe Phe Glu Gln  Ala Leu Thr Glu Glu  Thr Pro Gly 
    3545                 3550                 3555             


Val Gln  Asp Cys Tyr Tyr His  Tyr Gly Gln Ser Tyr  Arg Gly Thr 
    3560                 3565                 3570             


Tyr Ser  Thr Thr Val Thr Gly  Arg Thr Cys Gln Ala  Trp Ser Ser 
    3575                 3580                 3585             


Met Thr  Pro His Gln His Ser  Arg Thr Pro Glu Asn  Tyr Pro Asn 
    3590                 3595                 3600             


Ala Gly  Leu Thr Arg Asn Tyr  Cys Arg Asn Pro Asp  Ala Glu Ile 
    3605                 3610                 3615             


Arg Pro  Trp Cys Tyr Thr Met  Asp Pro Ser Val Arg  Trp Glu Tyr 
    3620                 3625                 3630             


Cys Asn  Leu Thr Gln Cys Leu  Val Thr Glu Ser Ser  Val Leu Ala 
    3635                 3640                 3645             


Thr Leu  Thr Val Val Pro Asp  Pro Ser Thr Glu Ala  Ser Ser Glu 
    3650                 3655                 3660             


Glu Ala  Pro Thr Glu Gln Ser  Pro Gly Val Gln Asp  Cys Tyr His 
    3665                 3670                 3675             


Gly Asp  Gly Gln Ser Tyr Arg  Gly Ser Phe Ser Thr  Thr Val Thr 
    3680                 3685                 3690             


Gly Arg  Thr Cys Gln Ser Trp  Ser Ser Met Thr Pro  His Trp His 
    3695                 3700                 3705             


Gln Arg  Thr Thr Glu Tyr Tyr  Pro Asn Gly Gly Leu  Thr Arg Asn 
    3710                 3715                 3720             


Tyr Cys  Arg Asn Pro Asp Ala  Glu Ile Ser Pro Trp  Cys Tyr Thr 
    3725                 3730                 3735             


Met Asp  Pro Asn Val Arg Trp  Glu Tyr Cys Asn Leu  Thr Gln Cys 
    3740                 3745                 3750             


Pro Val  Thr Glu Ser Ser Val  Leu Ala Thr Ser Thr  Ala Val Ser 
    3755                 3760                 3765             


Glu Gln  Ala Pro Thr Glu Gln  Ser Pro Thr Val Gln  Asp Cys Tyr 
    3770                 3775                 3780             


His Gly  Asp Gly Gln Ser Tyr  Arg Gly Ser Phe Ser  Thr Thr Val 
    3785                 3790                 3795             


Thr Gly  Arg Thr Cys Gln Ser  Trp Ser Ser Met Thr  Pro His Trp 
    3800                 3805                 3810             


His Gln  Arg Thr Thr Glu Tyr  Tyr Pro Asn Gly Gly  Leu Thr Arg 
    3815                 3820                 3825             


Asn Tyr  Cys Arg Asn Pro Asp  Ala Glu Ile Arg Pro  Trp Cys Tyr 
    3830                 3835                 3840             


Thr Met  Asp Pro Ser Val Arg  Trp Glu Tyr Cys Asn  Leu Thr Gln 
    3845                 3850                 3855             


Cys Pro  Val Met Glu Ser Thr  Leu Leu Thr Thr Pro  Thr Val Val 
    3860                 3865                 3870             


Pro Val  Pro Ser Thr Glu Leu  Pro Ser Glu Glu Ala  Pro Thr Glu 
    3875                 3880                 3885             


Asn Ser  Thr Gly Val Gln Asp  Cys Tyr Arg Gly Asp  Gly Gln Ser 
    3890                 3895                 3900             


Tyr Arg  Gly Thr Leu Ser Thr  Thr Ile Thr Gly Arg  Thr Cys Gln 
    3905                 3910                 3915             


Ser Trp  Ser Ser Met Thr Pro  His Trp His Arg Arg  Ile Pro Leu 
    3920                 3925                 3930             


Tyr Tyr  Pro Asn Ala Gly Leu  Thr Arg Asn Tyr Cys  Arg Asn Pro 
    3935                 3940                 3945             


Asp Ala  Glu Ile Arg Pro Trp  Cys Tyr Thr Met Asp  Pro Ser Val 
    3950                 3955                 3960             


Arg Trp  Glu Tyr Cys Asn Leu  Thr Arg Cys Pro Val  Thr Glu Ser 
    3965                 3970                 3975             


Ser Val  Leu Thr Thr Pro Thr  Val Ala Pro Val Pro  Ser Thr Glu 
    3980                 3985                 3990             


Ala Pro  Ser Glu Gln Ala Pro  Pro Glu Lys Ser Pro  Val Val Gln 
    3995                 4000                 4005             


Asp Cys  Tyr His Gly Asp Gly  Arg Ser Tyr Arg Gly  Ile Ser Ser 
    4010                 4015                 4020             


Thr Thr  Val Thr Gly Arg Thr  Cys Gln Ser Trp Ser  Ser Met Ile 
    4025                 4030                 4035             


Pro His  Trp His Gln Arg Thr  Pro Glu Asn Tyr Pro  Asn Ala Gly 
    4040                 4045                 4050             


Leu Thr  Glu Asn Tyr Cys Arg  Asn Pro Asp Ser Gly  Lys Gln Pro 
    4055                 4060                 4065             


Trp Cys  Tyr Thr Thr Asp Pro  Cys Val Arg Trp Glu  Tyr Cys Asn 
    4070                 4075                 4080             


Leu Thr  Gln Cys Ser Glu Thr  Glu Ser Gly Val Leu  Glu Thr Pro 
    4085                 4090                 4095             


Thr Val  Val Pro Val Pro Ser  Met Glu Ala His Ser  Glu Ala Ala 
    4100                 4105                 4110             


Pro Thr  Glu Gln Thr Pro Val  Val Arg Gln Cys Tyr  His Gly Asn 
    4115                 4120                 4125             


Gly Gln  Ser Tyr Arg Gly Thr  Phe Ser Thr Thr Val  Thr Gly Arg 
    4130                 4135                 4140             


Thr Cys  Gln Ser Trp Ser Ser  Met Thr Pro His Arg  His Gln Arg 
    4145                 4150                 4155             


Thr Pro  Glu Asn Tyr Pro Asn  Asp Gly Leu Thr Met  Asn Tyr Cys 
    4160                 4165                 4170             


Arg Asn  Pro Asp Ala Asp Thr  Gly Pro Trp Cys Phe  Thr Met Asp 
    4175                 4180                 4185             


Pro Ser  Ile Arg Trp Glu Tyr  Cys Asn Leu Thr Arg  Cys Ser Asp 
    4190                 4195                 4200             


Thr Glu  Gly Thr Val Val Ala  Pro Pro Thr Val Ile  Gln Val Pro 
    4205                 4210                 4215             


Ser Leu  Gly Pro Pro Ser Glu  Gln Asp Cys Met Phe  Gly Asn Gly 
    4220                 4225                 4230             


Lys Gly  Tyr Arg Gly Lys Lys  Ala Thr Thr Val Thr  Gly Thr Pro 
    4235                 4240                 4245             


Cys Gln  Glu Trp Ala Ala Gln  Glu Pro His Arg His  Ser Thr Phe 
    4250                 4255                 4260             


Ile Pro  Gly Thr Asn Lys Trp  Ala Gly Leu Glu Lys  Asn Tyr Cys 
    4265                 4270                 4275             


Arg Asn  Pro Asp Gly Asp Ile  Asn Gly Pro Trp Cys  Tyr Thr Met 
    4280                 4285                 4290             


Asn Pro  Arg Lys Leu Phe Asp  Tyr Cys Asp Ile Pro  Leu Cys Ala 
    4295                 4300                 4305             


Ser Ser  Ser Phe Asp Cys Gly  Lys Pro Gln Val Glu  Pro Lys Lys 
    4310                 4315                 4320             


Cys Pro  Gly Ser Ile Val Gly  Gly Cys Val Ala His  Pro His Ser 
    4325                 4330                 4335             


Trp Pro  Trp Gln Val Ser Leu  Arg Thr Arg Phe Gly  Lys His Phe 
    4340                 4345                 4350             


Cys Gly  Gly Thr Leu Ile Ser  Pro Glu Trp Val Leu  Thr Ala Ala 
    4355                 4360                 4365             


His Cys  Leu Lys Lys Ser Ser  Arg Pro Ser Ser Tyr  Lys Val Ile 
    4370                 4375                 4380             


Leu Gly  Ala His Gln Glu Val  Asn Leu Glu Ser His  Val Gln Glu 
    4385                 4390                 4395             


Ile Glu  Val Ser Arg Leu Phe  Leu Glu Pro Thr Gln  Ala Asp Ile 
    4400                 4405                 4410             


Ala Leu  Leu Lys Leu Ser Arg  Pro Ala Val Ile Thr  Asp Lys Val 
    4415                 4420                 4425             


Met Pro  Ala Cys Leu Pro Ser  Pro Asp Tyr Met Val  Thr Ala Arg 
    4430                 4435                 4440             


Thr Glu  Cys Tyr Ile Thr Gly  Trp Gly Glu Thr Gln  Gly Thr Phe 
    4445                 4450                 4455             


Gly Thr  Gly Leu Leu Lys Glu  Ala Gln Leu Leu Val  Ile Glu Asn 
    4460                 4465                 4470             


Glu Val  Cys Asn His Tyr Lys  Tyr Ile Cys Ala Glu  His Leu Ala 
    4475                 4480                 4485             


Arg Gly  Thr Asp Ser Cys Gln  Gly Asp Ser Gly Gly  Pro Leu Val 
    4490                 4495                 4500             


Cys Phe  Glu Lys Asp Lys Tyr  Ile Leu Gln Gly Val  Thr Ser Trp 
    4505                 4510                 4515             


Gly Leu  Gly Cys Ala Arg Pro  Asn Lys Pro Gly Val  Tyr Ala Arg 
    4520                 4525                 4530             


Val Ser  Arg Phe Val Thr Trp  Ile Glu Gly Met Met  Arg Asn Asn 
    4535                 4540                 4545             


<210>  90
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Gln Met Ser Tyr Ala Ile Arg Cys Ala Phe Tyr Gln Leu Leu Leu 
1               5                   10                  15      


Ala Ala Leu Met Leu Val Ala Met Leu Gln Leu Leu Tyr Leu Ser Leu 
            20                  25                  30          


Leu Ser Gly Leu His Gly Gln Glu Glu Gln Asp Gln Tyr Phe Glu Phe 
        35                  40                  45              


Phe Pro Pro Ser Pro Arg Ser Val Asp Gln Val Lys Ala Gln Leu Arg 
    50                  55                  60                  


Thr Ala Leu Ala Ser Gly Gly Val Leu Asp Ala Ser Gly Asp Tyr Arg 
65                  70                  75                  80  


Val Tyr Arg Gly Leu Leu Lys Thr Thr Met Asp Pro Asn Asp Val Ile 
                85                  90                  95      


Leu Ala Thr His Ala Ser Val Asp Asn Leu Leu His Leu Ser Gly Leu 
            100                 105                 110         


Leu Glu Arg Trp Glu Gly Pro Leu Ser Val Ser Val Phe Ala Ala Thr 
        115                 120                 125             


Lys Glu Glu Ala Gln Leu Ala Thr Val Leu Ala Tyr Ala Leu Ser Ser 
    130                 135                 140                 


His Cys Pro Asp Met Arg Ala Arg Val Ala Met His Leu Val Cys Pro 
145                 150                 155                 160 


Ser Arg Tyr Glu Ala Ala Val Pro Asp Pro Arg Glu Pro Gly Glu Phe 
                165                 170                 175     


Ala Leu Leu Arg Ser Cys Gln Glu Val Phe Asp Lys Leu Ala Arg Val 
            180                 185                 190         


Ala Gln Pro Gly Ile Asn Tyr Ala Leu Gly Thr Asn Val Ser Tyr Pro 
        195                 200                 205             


Asn Asn Leu Leu Arg Asn Leu Ala Arg Glu Gly Ala Asn Tyr Ala Leu 
    210                 215                 220                 


Val Ile Asp Val Asp Met Val Pro Ser Glu Gly Leu Trp Arg Gly Leu 
225                 230                 235                 240 


Arg Glu Met Leu Asp Gln Ser Asn Gln Trp Gly Gly Thr Ala Leu Val 
                245                 250                 255     


Val Pro Ala Phe Glu Ile Arg Arg Ala Arg Arg Met Pro Met Asn Lys 
            260                 265                 270         


Asn Glu Leu Val Gln Leu Tyr Gln Val Gly Glu Val Arg Pro Phe Tyr 
        275                 280                 285             


Tyr Gly Leu Cys Thr Pro Cys Gln Ala Pro Thr Asn Tyr Ser Arg Trp 
    290                 295                 300                 


Val Asn Leu Pro Glu Glu Ser Leu Leu Arg Pro Ala Tyr Val Val Pro 
305                 310                 315                 320 


Trp Gln Asp Pro Trp Glu Pro Phe Tyr Val Ala Gly Gly Lys Val Pro 
                325                 330                 335     


Thr Phe Asp Glu Arg Phe Arg Gln Tyr Gly Phe Asn Arg Ile Ser Gln 
            340                 345                 350         


Ala Cys Glu Leu His Val Ala Gly Phe Asp Phe Glu Val Leu Asn Glu 
        355                 360                 365             


Gly Phe Leu Val His Lys Gly Phe Lys Glu Ala Leu Lys Phe His Pro 
    370                 375                 380                 


Gln Lys Glu Ala Glu Asn Gln His Asn Lys Ile Leu Tyr Arg Gln Phe 
385                 390                 395                 400 


Lys Gln Glu Leu Lys Ala Lys Tyr Pro Asn Ser Pro Arg Arg Cys 
                405                 410                 415 


<210>  91
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Arg Thr Tyr Arg Tyr Phe Leu Leu Leu Phe Trp Val Gly Gln Pro 
1               5                   10                  15      


Tyr Pro Thr Leu Ser Thr Pro Leu Ser Lys Arg Thr Ser Gly Phe Pro 
            20                  25                  30          


Ala Lys Lys Arg Ala Leu Glu Leu Ser Gly Asn Ser Lys Asn Glu Leu 
        35                  40                  45              


Asn Arg Ser Lys Arg Ser Trp Met Trp Asn Gln Phe Phe Leu Leu Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Ser Asp Tyr Gln Tyr Val Gly Lys Leu His Ser Asp 
65                  70                  75                  80  


Gln Asp Arg Gly Asp Gly Ser Leu Lys Tyr Ile Leu Ser Gly Asp Gly 
                85                  90                  95      


Ala Gly Asp Leu Phe Ile Ile Asn Glu Asn Thr Gly Asp Ile Gln Ala 
            100                 105                 110         


Thr Lys Arg Leu Asp Arg Glu Glu Lys Pro Val Tyr Ile Leu Arg Ala 
        115                 120                 125             


Gln Ala Ile Asn Arg Arg Thr Gly Arg Pro Val Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Ile His Asp Ile Asn Asp Asn Glu Pro Ile Phe Thr 
145                 150                 155                 160 


Lys Glu Val Tyr Thr Ala Thr Val Pro Glu Met Ser Asp Val Gly Thr 
                165                 170                 175     


Phe Val Val Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ser Glu Thr Gly Ile Ile Lys Thr Ala Leu Leu Asn Met 
    210                 215                 220                 


Asp Arg Glu Asn Arg Glu Gln Tyr Gln Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly Gln Met Gly Gly Leu Ser Gly Thr Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Ser Thr 
            260                 265                 270         


Tyr Gln Phe Lys Thr Pro Glu Ser Ser Pro Pro Gly Thr Pro Ile Gly 
        275                 280                 285             


Arg Ile Lys Ala Ser Asp Ala Asp Val Gly Glu Asn Ala Glu Ile Glu 
    290                 295                 300                 


Tyr Ser Ile Thr Asp Gly Glu Gly Leu Asp Met Phe Asp Val Ile Thr 
305                 310                 315                 320 


Asp Gln Glu Thr Gln Glu Gly Ile Ile Thr Val Lys Lys Leu Leu Asp 
                325                 330                 335     


Phe Glu Lys Lys Lys Val Tyr Thr Leu Lys Val Glu Ala Ser Asn Pro 
            340                 345                 350         


Tyr Val Glu Pro Arg Phe Leu Tyr Leu Gly Pro Phe Lys Asp Ser Ala 
        355                 360                 365             


Thr Val Arg Ile Val Val Glu Asp Val Asp Glu Pro Pro Val Phe Ser 
    370                 375                 380                 


Lys Leu Ala Tyr Ile Leu Gln Ile Arg Glu Asp Ala Gln Ile Asn Thr 
385                 390                 395                 400 


Thr Ile Gly Ser Val Thr Ala Gln Asp Pro Asp Ala Ala Arg Asn Pro 
                405                 410                 415     


Val Lys Tyr Ser Val Asp Arg His Thr Asp Met Asp Arg Ile Phe Asn 
            420                 425                 430         


Ile Asp Ser Gly Asn Gly Ser Ile Phe Thr Ser Lys Leu Leu Asp Arg 
        435                 440                 445             


Glu Thr Leu Leu Trp His Asn Ile Thr Val Ile Ala Thr Glu Ile Asn 
    450                 455                 460                 


Asn Pro Lys Gln Ser Ser Arg Val Pro Leu Tyr Ile Lys Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Ala Pro Glu Phe Ala Glu Phe Tyr Glu Thr Phe Val 
                485                 490                 495     


Cys Glu Lys Ala Lys Ala Asp Gln Leu Ile Gln Thr Leu His Ala Val 
            500                 505                 510         


Asp Lys Asp Asp Pro Tyr Ser Gly His Gln Phe Ser Phe Ser Leu Ala 
        515                 520                 525             


Pro Glu Ala Ala Ser Gly Ser Asn Phe Thr Ile Gln Asp Asn Lys Asp 
    530                 535                 540                 


Asn Thr Ala Gly Ile Leu Thr Arg Lys Asn Gly Tyr Asn Arg His Glu 
545                 550                 555                 560 


Met Ser Thr Tyr Leu Leu Pro Val Val Ile Ser Asp Asn Asp Tyr Pro 
                565                 570                 575     


Val Gln Ser Ser Thr Gly Thr Val Thr Val Arg Val Cys Ala Cys Asp 
            580                 585                 590         


His His Gly Asn Met Gln Ser Cys His Ala Glu Ala Leu Ile His Pro 
        595                 600                 605             


Thr Gly Leu Ser Thr Gly Ala Leu Val Ala Ile Leu Leu Cys Ile Val 
    610                 615                 620                 


Ile Leu Leu Val Thr Val Val Leu Phe Ala Ala Leu Arg Arg Gln Arg 
625                 630                 635                 640 


Lys Lys Glu Pro Leu Ile Ile Ser Lys Glu Asp Ile Arg Asp Asn Ile 
                645                 650                 655     


Val Ser Tyr Asn Asp Glu Gly Gly Gly Glu Glu Asp Thr Gln Ala Phe 
            660                 665                 670         


Asp Ile Gly Thr Leu Arg Asn Pro Glu Ala Ile Glu Asp Asn Lys Leu 
        675                 680                 685             


Arg Arg Asp Ile Val Pro Glu Ala Leu Phe Leu Pro Arg Arg Thr Pro 
    690                 695                 700                 


Thr Ala Arg Asp Asn Thr Asp Val Arg Asp Phe Ile Asn Gln Arg Leu 
705                 710                 715                 720 


Lys Glu Asn Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Ala 
                725                 730                 735     


Thr Tyr Ala Tyr Glu Gly Thr Gly Ser Val Ala Asp Ser Leu Ser Ser 
            740                 745                 750         


Leu Glu Ser Val Thr Thr Asp Ala Asp Gln Asp Tyr Asp Tyr Leu Ser 
        755                 760                 765             


Asp Trp Gly Pro Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Val 
    770                 775                 780                 


Asp Ser Asp Lys Asp Ser 
785                 790 


<210>  92
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Arg Thr Tyr Arg Tyr Phe Leu Leu Leu Phe Trp Val Gly Gln Pro 
1               5                   10                  15      


Tyr Pro Thr Leu Ser Thr Pro Leu Ser Lys Arg Thr Ser Gly Phe Pro 
            20                  25                  30          


Ala Lys Lys Arg Ala Leu Glu Leu Ser Gly Asn Ser Lys Asn Glu Leu 
        35                  40                  45              


Asn Arg Ser Lys Arg Ser Trp Met Trp Asn Gln Phe Phe Leu Leu Glu 
    50                  55                  60                  


Glu Tyr Thr Gly Ser Asp Tyr Gln Tyr Val Gly Lys Leu His Ser Asp 
65                  70                  75                  80  


Gln Asp Arg Gly Asp Gly Ser Leu Lys Tyr Ile Leu Ser Gly Asp Gly 
                85                  90                  95      


Ala Gly Asp Leu Phe Ile Ile Asn Glu Asn Thr Gly Asp Ile Gln Ala 
            100                 105                 110         


Thr Lys Arg Leu Asp Arg Glu Glu Lys Pro Val Tyr Ile Leu Arg Ala 
        115                 120                 125             


Gln Ala Ile Asn Arg Arg Thr Gly Arg Pro Val Glu Pro Glu Ser Glu 
    130                 135                 140                 


Phe Ile Ile Lys Ile His Asp Ile Asn Asp Asn Glu Pro Ile Phe Thr 
145                 150                 155                 160 


Lys Glu Val Tyr Thr Ala Thr Val Pro Glu Met Ser Asp Val Gly Thr 
                165                 170                 175     


Phe Val Val Gln Val Thr Ala Thr Asp Ala Asp Asp Pro Thr Tyr Gly 
            180                 185                 190         


Asn Ser Ala Lys Val Val Tyr Ser Ile Leu Gln Gly Gln Pro Tyr Phe 
        195                 200                 205             


Ser Val Glu Ser Glu Thr Gly Ile Ile Lys Thr Ala Leu Leu Asn Met 
    210                 215                 220                 


Asp Arg Glu Asn Arg Glu Gln Tyr Gln Val Val Ile Gln Ala Lys Asp 
225                 230                 235                 240 


Met Gly Gly Gln Met Gly Gly Leu Ser Gly Thr Thr Thr Val Asn Ile 
                245                 250                 255     


Thr Leu Thr Asp Val Asn Asp Asn Pro Pro Arg Phe Pro Gln Ser Thr 
            260                 265                 270         


Tyr Gln Phe Lys Thr Pro Glu Ser Ser Pro Pro Gly Thr Pro Ile Gly 
        275                 280                 285             


Arg Ile Lys Ala Ser Asp Ala Asp Val Gly Glu Asn Ala Glu Ile Glu 
    290                 295                 300                 


Tyr Ser Ile Thr Asp Gly Glu Gly Leu Asp Met Phe Asp Val Ile Thr 
305                 310                 315                 320 


Asp Gln Glu Thr Gln Glu Gly Ile Ile Thr Val Lys Lys Leu Leu Asp 
                325                 330                 335     


Phe Glu Lys Lys Lys Val Tyr Thr Leu Lys Val Glu Ala Ser Asn Pro 
            340                 345                 350         


Tyr Val Glu Pro Arg Phe Leu Tyr Leu Gly Pro Phe Lys Asp Ser Ala 
        355                 360                 365             


Thr Val Arg Ile Val Val Glu Asp Val Asp Glu Pro Pro Val Phe Ser 
    370                 375                 380                 


Lys Leu Ala Tyr Ile Leu Gln Ile Arg Glu Asp Ala Gln Ile Asn Thr 
385                 390                 395                 400 


Thr Ile Gly Ser Val Thr Ala Gln Asp Pro Asp Ala Ala Arg Asn Pro 
                405                 410                 415     


Val Lys Tyr Ser Val Asp Arg His Thr Asp Met Asp Arg Ile Phe Asn 
            420                 425                 430         


Ile Asp Ser Gly Asn Gly Ser Ile Phe Thr Ser Lys Leu Leu Asp Arg 
        435                 440                 445             


Glu Thr Leu Leu Trp His Asn Ile Thr Val Ile Ala Thr Glu Ile Asn 
    450                 455                 460                 


Asn Pro Lys Gln Ser Ser Arg Val Pro Leu Tyr Ile Lys Val Leu Asp 
465                 470                 475                 480 


Val Asn Asp Asn Ala Pro Glu Phe Ala Glu Phe Tyr Glu Thr Phe Val 
                485                 490                 495     


Cys Glu Lys Ala Lys Ala Asp Gln Leu Ile Gln Thr Leu His Ala Val 
            500                 505                 510         


Asp Lys Asp Asp Pro Tyr Ser Gly His Gln Phe Ser Phe Ser Leu Ala 
        515                 520                 525             


Pro Glu Ala Ala Ser Gly Ser Asn Phe Thr Ile Gln Asp Asn Lys Asp 
    530                 535                 540                 


Asn Thr Ala Gly Ile Leu Thr Arg Lys Asn Gly Tyr Asn Arg His Glu 
545                 550                 555                 560 


Met Ser Thr Tyr Leu Leu Pro Val Val Ile Ser Asp Asn Asp Tyr Pro 
                565                 570                 575     


Val Gln Ser Ser Thr Gly Thr Val Thr Val Arg Val Cys Ala Cys Asp 
            580                 585                 590         


His His Gly Asn Met Gln Ser Cys His Ala Glu Ala Leu Ile His Pro 
        595                 600                 605             


Thr Gly Leu Ser Thr Gly Ala Leu Val Ala Ile Leu Leu Cys Ile Val 
    610                 615                 620                 


Ile Leu Leu Gly Lys Leu Val Leu Pro Ala Ser Tyr Leu Pro Met Val 
625                 630                 635                 640 


Arg Gly Ser His Cys Tyr Cys Asp Thr Leu Asp Leu Ser Ala Ser Pro 
                645                 650                 655     


Ile Lys Ala Tyr Ser Leu Ile 
            660             


<210>  93
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ser Gly Gly Arg Ala Pro Ala Val Leu Leu Gly Gly Val Ala Ser 
1               5                   10                  15      


Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu Leu Pro Val Ala Ser 
            20                  25                  30          


Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr Met Ala Ser Gly Ser 
        35                  40                  45              


Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser Gly Ser Gly Tyr Val 
    50                  55                  60                  


Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn Glu Lys Val 
65                  70                  75                  80  


Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu Ala Ala Cys 
                85                  90                  95      


Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp Lys Gly Lys 
            100                 105                 110         


Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile Lys Thr Gln Ser Ser 
        115                 120                 125             


Leu Val Pro Ala Leu Thr Asp Phe Val Arg Ser Val His Pro Tyr Glu 
    130                 135                 140                 


Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln Gly Asn Phe Pro Tyr 
145                 150                 155                 160 


Leu Gln Trp Val Arg Gln Val Thr Glu Ser Val Ser Asp Ser Ile Thr 
                165                 170                 175     


Val Leu Pro 
            


<210>  94
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ile Gly Ser Gly Leu Ala Gly Ser Gly Gly Ala Gly Gly Pro Ser 
1               5                   10                  15      


Ser Thr Val Thr Trp Cys Ala Leu Phe Ser Asn His Val Ala Ala Thr 
            20                  25                  30          


Gln Ala Ser Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu Leu Pro 
        35                  40                  45              


Val Ala Ser Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr Met Ala 
    50                  55                  60                  


Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser Gly Ser 
65                  70                  75                  80  


Gly Tyr Val Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn 
                85                  90                  95      


Glu Lys Val Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu 
            100                 105                 110         


Ala Ala Cys Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp 
        115                 120                 125             


Lys Gly Lys Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile Lys Thr 
    130                 135                 140                 


Gln Ser Ser Leu Val Pro Ala Leu Thr Asp Phe Val Arg Ser Val His 
145                 150                 155                 160 


Pro Tyr Glu Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln Gly Asn 
                165                 170                 175     


Phe Pro Tyr Leu Gln Trp Val Arg Gln Val Thr Glu Ser Val Ser Asp 
            180                 185                 190         


Ser Ile Thr Val Leu Pro 
        195             


<210>  95
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Pro Ala Leu Leu Pro Val Ala Ser Arg Leu Leu Leu Leu Pro Arg 
1               5                   10                  15      


Val Leu Leu Thr Met Ala Ser Gly Ser Pro Pro Thr Gln Pro Ser Pro 
            20                  25                  30          


Ala Ser Asp Ser Gly Ser Gly Tyr Val Pro Gly Ser Val Ser Ala Ala 
        35                  40                  45              


Phe Val Thr Cys Pro Asn Glu Lys Val Ala Lys Glu Ile Ala Arg Ala 
    50                  55                  60                  


Val Val Glu Lys Arg Leu Ala Ala Cys Val Asn Leu Ile Pro Gln Ile 
65                  70                  75                  80  


Thr Ser Ile Tyr Glu Trp Lys Gly Lys Ile Glu Glu Asp Ser Glu Val 
                85                  90                  95      


Leu Met Met Ile Lys Thr Gln Ser Ser Leu Val Pro Ala Leu Thr Asp 
            100                 105                 110         


Phe Val Arg Ser Val His Pro Tyr Glu Val Ala Glu Val Ile Ala Leu 
        115                 120                 125             


Pro Val Glu Gln Gly Asn Phe Pro Tyr Leu Gln Trp Val Arg Gln Val 
    130                 135                 140                 


Thr Glu Ser Val Ser Asp Ser Ile Thr Val Leu Pro 
145                 150                 155     


<210>  96
<211>  2413
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
    450                 455                 460                 


Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro Thr Ile Thr 
465                 470                 475                 480 


Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu 
                485                 490                 495     


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
            500                 505                 510         


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala 
        515                 520                 525             


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Leu Ala Pro 
    530                 535                 540                 


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
545                 550                 555                 560 


Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
                565                 570                 575     


Gly Trp Leu Ser His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile 
            580                 585                 590         


Cys Ser Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
        595                 600                 605             


Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
    610                 615                 620                 


Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
625                 630                 635                 640 


Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg 
                645                 650                 655     


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
            660                 665                 670         


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro Asn Asn Gly Trp Leu Ser 
        675                 680                 685             


His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Ala 
    690                 695                 700                 


Gln Ser Arg Ser Thr Pro Arg Pro Asp Thr Leu Ser Thr Ile Thr Leu 
705                 710                 715                 720 


Pro Pro Ser Thr Val Gly Ser Glu Ser Ser Leu Thr Leu Arg Leu Val 
                725                 730                 735     


Asn Gly Ser Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly 
            740                 745                 750         


Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn 
        755                 760                 765             


Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly 
    770                 775                 780                 


Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val 
785                 790                 795                 800 


Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly 
                805                 810                 815     


Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys 
            820                 825                 830         


Ser Val Ser Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr 
        835                 840                 845             


Ser His Ala Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu 
    850                 855                 860                 


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
865                 870                 875                 880 


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala 
                885                 890                 895     


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro 
            900                 905                 910         


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
        915                 920                 925             


Val Arg Cys Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
    930                 935                 940                 


Gly Trp Leu Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile 
945                 950                 955                 960 


Cys Ser Ala Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro 
                965                 970                 975     


Thr Ile Thr Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala 
            980                 985                 990         


Leu Arg Leu Val Asn Gly Gly Asp  Arg Cys Gln Gly Arg  Val Glu Val 
        995                 1000                 1005             


Leu Tyr  Gln Gly Ser Trp Gly  Thr Val Cys Asp Asp  Ser Trp Asp 
    1010                 1015                 1020             


Thr Asn  Asp Ala Asn Val Val  Cys Arg Gln Leu Gly  Cys Gly Trp 
    1025                 1030                 1035             


Ala Met  Ser Ala Pro Gly Asn  Ala Arg Phe Gly Gln  Gly Ser Gly 
    1040                 1045                 1050             


Pro Ile  Val Leu Asp Asp Val  Arg Cys Ser Gly His  Glu Ser Tyr 
    1055                 1060                 1065             


Leu Trp  Ser Cys Pro His Asn  Gly Trp Leu Ser His  Asn Cys Gly 
    1070                 1075                 1080             


His Ser  Glu Asp Ala Gly Val  Ile Cys Ser Ala Ser  Gln Ser Arg 
    1085                 1090                 1095             


Pro Thr  Pro Ser Pro Asp Thr  Trp Pro Thr Ser His  Ala Ser Thr 
    1100                 1105                 1110             


Ala Gly  Ser Glu Ser Ser Leu  Ala Leu Arg Leu Val  Asn Gly Gly 
    1115                 1120                 1125             


Asp Arg  Cys Gln Gly Arg Val  Glu Val Leu Tyr Arg  Gly Ser Trp 
    1130                 1135                 1140             


Gly Thr  Val Cys Asp Asp Tyr  Trp Asp Thr Asn Asp  Ala Asn Val 
    1145                 1150                 1155             


Val Cys  Arg Gln Leu Gly Cys  Gly Trp Ala Met Ser  Ala Pro Gly 
    1160                 1165                 1170             


Asn Ala  Arg Phe Gly Gln Gly  Ser Gly Pro Ile Val  Leu Asp Asp 
    1175                 1180                 1185             


Val Arg  Cys Ser Gly His Glu  Ser Tyr Leu Trp Ser  Cys Pro His 
    1190                 1195                 1200             


Asn Gly  Trp Leu Ser His Asn  Cys Gly His His Glu  Asp Ala Gly 
    1205                 1210                 1215             


Val Ile  Cys Ser Ala Ser Gln  Ser Gln Pro Thr Pro  Ser Pro Asp 
    1220                 1225                 1230             


Thr Trp  Pro Thr Ser His Ala  Ser Thr Ala Gly Ser  Glu Ser Ser 
    1235                 1240                 1245             


Leu Ala  Leu Arg Leu Val Asn  Gly Gly Asp Arg Cys  Gln Gly Arg 
    1250                 1255                 1260             


Val Glu  Val Leu Tyr Arg Gly  Ser Trp Gly Thr Val  Cys Asp Asp 
    1265                 1270                 1275             


Tyr Trp  Asp Thr Asn Asp Ala  Asn Val Val Cys Arg  Gln Leu Gly 
    1280                 1285                 1290             


Cys Gly  Trp Ala Thr Ser Ala  Pro Gly Asn Ala Arg  Phe Gly Gln 
    1295                 1300                 1305             


Gly Ser  Gly Pro Ile Val Leu  Asp Asp Val Arg Cys  Ser Gly His 
    1310                 1315                 1320             


Glu Ser  Tyr Leu Trp Ser Cys  Pro His Asn Gly Trp  Leu Ser His 
    1325                 1330                 1335             


Asn Cys  Gly His His Glu Asp  Ala Gly Val Ile Cys  Ser Ala Ser 
    1340                 1345                 1350             


Gln Ser  Gln Pro Thr Pro Ser  Pro Asp Thr Trp Pro  Thr Ser His 
    1355                 1360                 1365             


Ala Ser  Thr Ala Gly Ser Glu  Ser Ser Leu Ala Leu  Arg Leu Val 
    1370                 1375                 1380             


Asn Gly  Gly Asp Arg Cys Gln  Gly Arg Val Glu Val  Leu Tyr Arg 
    1385                 1390                 1395             


Gly Ser  Trp Gly Thr Val Cys  Asp Asp Tyr Trp Asp  Thr Asn Asp 
    1400                 1405                 1410             


Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys Gly Trp  Ala Thr Ser 
    1415                 1420                 1425             


Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly Ser Gly  Pro Ile Val 
    1430                 1435                 1440             


Leu Asp  Asp Val Arg Cys Ser  Gly His Glu Ser Tyr  Leu Trp Ser 
    1445                 1450                 1455             


Cys Pro  His Asn Gly Trp Leu  Ser His Asn Cys Gly  His His Glu 
    1460                 1465                 1470             


Asp Ala  Gly Val Ile Cys Ser  Ala Ser Gln Ser Gln  Pro Thr Pro 
    1475                 1480                 1485             


Ser Pro  Asp Thr Trp Pro Thr  Ser Arg Ala Ser Thr  Ala Gly Ser 
    1490                 1495                 1500             


Glu Ser  Thr Leu Ala Leu Arg  Leu Val Asn Gly Gly  Asp Arg Cys 
    1505                 1510                 1515             


Arg Gly  Arg Val Glu Val Leu  Tyr Gln Gly Ser Trp  Gly Thr Val 
    1520                 1525                 1530             


Cys Asp  Asp Tyr Trp Asp Thr  Asn Asp Ala Asn Val  Val Cys Arg 
    1535                 1540                 1545             


Gln Leu  Gly Cys Gly Trp Ala  Met Ser Ala Pro Gly  Asn Ala Gln 
    1550                 1555                 1560             


Phe Gly  Gln Gly Ser Gly Pro  Ile Val Leu Asp Asp  Val Arg Cys 
    1565                 1570                 1575             


Ser Gly  His Glu Ser Tyr Leu  Trp Ser Cys Pro His  Asn Gly Trp 
    1580                 1585                 1590             


Leu Ser  His Asn Cys Gly His  His Glu Asp Ala Gly  Val Ile Cys 
    1595                 1600                 1605             


Ser Ala  Ala Gln Ser Gln Ser  Thr Pro Arg Pro Asp  Thr Trp Leu 
    1610                 1615                 1620             


Thr Thr  Asn Leu Pro Ala Leu  Thr Val Gly Ser Glu  Ser Ser Leu 
    1625                 1630                 1635             


Ala Leu  Arg Leu Val Asn Gly  Gly Asp Arg Cys Arg  Gly Arg Val 
    1640                 1645                 1650             


Glu Val  Leu Tyr Arg Gly Ser  Trp Gly Thr Val Cys  Asp Asp Ser 
    1655                 1660                 1665             


Trp Asp  Thr Asn Asp Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys 
    1670                 1675                 1680             


Gly Trp  Ala Met Ser Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly 
    1685                 1690                 1695             


Ser Gly  Pro Ile Val Leu Asp  Asp Val Arg Cys Ser  Gly Asn Glu 
    1700                 1705                 1710             


Ser Tyr  Leu Trp Ser Cys Pro  His Lys Gly Trp Leu  Thr His Asn 
    1715                 1720                 1725             


Cys Gly  His His Glu Asp Ala  Gly Val Ile Cys Ser  Ala Thr Gln 
    1730                 1735                 1740             


Ile Asn  Ser Thr Thr Thr Asp  Trp Trp His Pro Thr  Thr Thr Thr 
    1745                 1750                 1755             


Thr Ala  Arg Pro Ser Ser Asn  Cys Gly Gly Phe Leu  Phe Tyr Ala 
    1760                 1765                 1770             


Ser Gly  Thr Phe Ser Ser Pro  Ser Tyr Pro Ala Tyr  Tyr Pro Asn 
    1775                 1780                 1785             


Asn Ala  Lys Cys Val Trp Glu  Ile Glu Val Asn Ser  Gly Tyr Arg 
    1790                 1795                 1800             


Ile Asn  Leu Gly Phe Ser Asn  Leu Lys Leu Glu Ala  His His Asn 
    1805                 1810                 1815             


Cys Ser  Phe Asp Tyr Val Glu  Ile Phe Asp Gly Ser  Leu Asn Ser 
    1820                 1825                 1830             


Ser Leu  Leu Leu Gly Lys Ile  Cys Asn Asp Thr Arg  Gln Ile Phe 
    1835                 1840                 1845             


Thr Ser  Ser Tyr Asn Arg Met  Thr Ile His Phe Arg  Ser Asp Ile 
    1850                 1855                 1860             


Ser Phe  Gln Asn Thr Gly Phe  Leu Ala Trp Tyr Asn  Ser Phe Pro 
    1865                 1870                 1875             


Ser Asp  Ala Thr Leu Arg Leu  Val Asn Leu Asn Ser  Ser Tyr Gly 
    1880                 1885                 1890             


Leu Cys  Ala Gly Arg Val Glu  Ile Tyr His Gly Gly  Thr Trp Gly 
    1895                 1900                 1905             


Thr Val  Cys Asp Asp Ser Trp  Thr Ile Gln Glu Ala  Glu Val Val 
    1910                 1915                 1920             


Cys Arg  Gln Leu Gly Cys Gly  Arg Ala Val Ser Ala  Leu Gly Asn 
    1925                 1930                 1935             


Ala Tyr  Phe Gly Ser Gly Ser  Gly Pro Ile Thr Leu  Asp Asp Val 
    1940                 1945                 1950             


Glu Cys  Ser Gly Thr Glu Ser  Thr Leu Trp Gln Cys  Arg Asn Arg 
    1955                 1960                 1965             


Gly Trp  Phe Ser His Asn Cys  Asn His Arg Glu Asp  Ala Gly Val 
    1970                 1975                 1980             


Ile Cys  Ser Gly Asn His Leu  Ser Thr Pro Ala Pro  Phe Leu Asn 
    1985                 1990                 1995             


Ile Thr  Arg Pro Asn Thr Asp  Tyr Ser Cys Gly Gly  Phe Leu Ser 
    2000                 2005                 2010             


Gln Pro  Ser Gly Asp Phe Ser  Ser Pro Phe Tyr Pro  Gly Asn Tyr 
    2015                 2020                 2025             


Pro Asn  Asn Ala Lys Cys Val  Trp Asp Ile Glu Val  Gln Asn Asn 
    2030                 2035                 2040             


Tyr Arg  Val Thr Val Ile Phe  Arg Asp Val Gln Leu  Glu Gly Gly 
    2045                 2050                 2055             


Cys Asn  Tyr Asp Tyr Ile Glu  Val Phe Asp Gly Pro  Tyr Arg Ser 
    2060                 2065                 2070             


Ser Pro  Leu Ile Ala Arg Val  Cys Asp Gly Ala Arg  Gly Ser Phe 
    2075                 2080                 2085             


Thr Ser  Ser Ser Asn Phe Met  Ser Ile Arg Phe Ile  Ser Asp His 
    2090                 2095                 2100             


Ser Ile  Thr Arg Arg Gly Phe  Arg Ala Glu Tyr Tyr  Ser Ser Pro 
    2105                 2110                 2115             


Ser Asn  Asp Ser Thr Asn Leu  Leu Cys Leu Pro Asn  His Met Gln 
    2120                 2125                 2130             


Ala Ser  Val Ser Arg Ser Tyr  Leu Gln Ser Leu Gly  Phe Ser Ala 
    2135                 2140                 2145             


Ser Asp  Leu Val Ile Ser Thr  Trp Asn Gly Tyr Tyr  Glu Cys Arg 
    2150                 2155                 2160             


Pro Gln  Ile Thr Pro Asn Leu  Val Ile Phe Thr Ile  Pro Tyr Ser 
    2165                 2170                 2175             


Gly Cys  Gly Thr Phe Lys Gln  Ala Asp Asn Asp Thr  Ile Asp Tyr 
    2180                 2185                 2190             


Ser Asn  Phe Leu Thr Ala Ala  Val Ser Gly Gly Ile  Ile Lys Arg 
    2195                 2200                 2205             


Arg Thr  Asp Leu Arg Ile His  Val Ser Cys Arg Met  Leu Gln Asn 
    2210                 2215                 2220             


Thr Trp  Val Asp Thr Met Tyr  Ile Ala Asn Asp Thr  Ile His Val 
    2225                 2230                 2235             


Ala Asn  Asn Thr Ile Gln Val  Glu Glu Val Gln Tyr  Gly Asn Phe 
    2240                 2245                 2250             


Asp Val  Asn Ile Ser Phe Tyr  Thr Ser Ser Ser Phe  Leu Tyr Pro 
    2255                 2260                 2265             


Val Thr  Ser Arg Pro Tyr Tyr  Val Asp Leu Asn Gln  Asp Leu Tyr 
    2270                 2275                 2280             


Val Gln  Ala Glu Ile Leu His  Ser Asp Ala Val Leu  Thr Leu Phe 
    2285                 2290                 2295             


Val Asp  Thr Cys Val Ala Ser  Pro Tyr Ser Asn Asp  Phe Thr Ser 
    2300                 2305                 2310             


Leu Thr  Tyr Asp Leu Ile Arg  Ser Gly Cys Val Arg  Asp Asp Thr 
    2315                 2320                 2325             


Tyr Gly  Pro Tyr Ser Ser Pro  Ser Leu Arg Ile Ala  Arg Phe Arg 
    2330                 2335                 2340             


Phe Arg  Ala Phe His Phe Leu  Asn Arg Phe Pro Ser  Val Tyr Leu 
    2345                 2350                 2355             


Arg Cys  Lys Met Val Val Cys  Arg Ala Tyr Asp Pro  Ser Ser Arg 
    2360                 2365                 2370             


Cys Tyr  Arg Gly Cys Val Leu  Arg Ser Lys Arg Asp  Val Gly Ser 
    2375                 2380                 2385             


Tyr Gln  Glu Lys Val Asp Val  Val Leu Gly Pro Ile  Gln Leu Gln 
    2390                 2395                 2400             


Thr Pro  Pro Arg Arg Glu Glu  Glu Pro Arg 
    2405                 2410             


<210>  97
<211>  1785
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
    450                 455                 460                 


Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro Thr Ile Thr 
465                 470                 475                 480 


Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu 
                485                 490                 495     


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Gln 
            500                 505                 510         


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala 
        515                 520                 525             


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro 
    530                 535                 540                 


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
545                 550                 555                 560 


Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
                565                 570                 575     


Gly Trp Leu Ser His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile 
            580                 585                 590         


Cys Ser Ala Ser Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro 
        595                 600                 605             


Thr Ser His Ala Ser Thr Ala Gly Ser Glu Ser Ser Leu Ala Leu Arg 
    610                 615                 620                 


Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr 
625                 630                 635                 640 


Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp 
                645                 650                 655     


Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala 
            660                 665                 670         


Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp 
        675                 680                 685             


Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His 
    690                 695                 700                 


Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly Val 
705                 710                 715                 720 


Ile Cys Ser Ala Ser Gln Ser Gln Pro Thr Pro Ser Pro Asp Thr Trp 
                725                 730                 735     


Pro Thr Ser His Ala Ser Thr Ala Gly Ser Glu Ser Ser Leu Ala Leu 
            740                 745                 750         


Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu 
        755                 760                 765             


Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn 
    770                 775                 780                 


Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser 
785                 790                 795                 800 


Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu 
                805                 810                 815     


Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro 
            820                 825                 830         


His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly 
        835                 840                 845             


Val Ile Cys Ser Ala Ser Gln Ser Gln Pro Thr Pro Ser Pro Asp Thr 
    850                 855                 860                 


Trp Pro Thr Ser Arg Ala Ser Thr Ala Gly Ser Glu Ser Thr Leu Ala 
865                 870                 875                 880 


Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Arg Gly Arg Val Glu Val 
                885                 890                 895     


Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp Thr 
            900                 905                 910         


Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met 
        915                 920                 925             


Ser Ala Pro Gly Asn Ala Gln Phe Gly Gln Gly Ser Gly Pro Ile Val 
    930                 935                 940                 


Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys 
945                 950                 955                 960 


Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala 
                965                 970                 975     


Gly Val Ile Cys Ser Ala Ala Gln Ser Gln Ser Thr Pro Arg Pro Asp 
            980                 985                 990         


Thr Trp Leu Thr Thr Asn Leu Pro  Ala Leu Thr Val Gly  Ser Glu Ser 
        995                 1000                 1005             


Ser Leu  Ala Leu Arg Leu Val  Asn Gly Gly Asp Arg  Cys Arg Gly 
    1010                 1015                 1020             


Arg Val  Glu Val Leu Tyr Arg  Gly Ser Trp Gly Thr  Val Cys Asp 
    1025                 1030                 1035             


Asp Ser  Trp Asp Thr Asn Asp  Ala Asn Val Val Cys  Arg Gln Leu 
    1040                 1045                 1050             


Gly Cys  Gly Trp Ala Met Ser  Ala Pro Gly Asn Ala  Arg Phe Gly 
    1055                 1060                 1065             


Gln Gly  Ser Gly Pro Ile Val  Leu Asp Asp Val Arg  Cys Ser Gly 
    1070                 1075                 1080             


Asn Glu  Ser Tyr Leu Trp Ser  Cys Pro His Lys Gly  Trp Leu Thr 
    1085                 1090                 1095             


His Asn  Cys Gly His His Glu  Asp Ala Gly Val Ile  Cys Ser Ala 
    1100                 1105                 1110             


Thr Gln  Ile Asn Ser Thr Thr  Thr Asp Trp Trp His  Pro Thr Thr 
    1115                 1120                 1125             


Thr Thr  Thr Ala Arg Pro Ser  Ser Asn Cys Gly Gly  Phe Leu Phe 
    1130                 1135                 1140             


Tyr Ala  Ser Gly Thr Phe Ser  Ser Pro Ser Tyr Pro  Ala Tyr Tyr 
    1145                 1150                 1155             


Pro Asn  Asn Ala Lys Cys Val  Trp Glu Ile Glu Val  Asn Ser Gly 
    1160                 1165                 1170             


Tyr Arg  Ile Asn Leu Gly Phe  Ser Asn Leu Lys Leu  Glu Ala His 
    1175                 1180                 1185             


His Asn  Cys Ser Phe Asp Tyr  Val Glu Ile Phe Asp  Gly Ser Leu 
    1190                 1195                 1200             


Asn Ser  Ser Leu Leu Leu Gly  Lys Ile Cys Asn Asp  Thr Arg Gln 
    1205                 1210                 1215             


Ile Phe  Thr Ser Ser Tyr Asn  Arg Met Thr Ile His  Phe Arg Ser 
    1220                 1225                 1230             


Asp Ile  Ser Phe Gln Asn Thr  Gly Phe Leu Ala Trp  Tyr Asn Ser 
    1235                 1240                 1245             


Phe Pro  Ser Asp Ala Thr Leu  Arg Leu Val Asn Leu  Asn Ser Ser 
    1250                 1255                 1260             


Tyr Gly  Leu Cys Ala Gly Arg  Val Glu Ile Tyr His  Gly Gly Thr 
    1265                 1270                 1275             


Trp Gly  Thr Val Cys Asp Asp  Ser Trp Thr Ile Gln  Glu Ala Glu 
    1280                 1285                 1290             


Val Val  Cys Arg Gln Leu Gly  Cys Gly Arg Ala Val  Ser Ala Leu 
    1295                 1300                 1305             


Gly Asn  Ala Tyr Phe Gly Ser  Gly Ser Gly Pro Ile  Thr Leu Asp 
    1310                 1315                 1320             


Asp Val  Glu Cys Ser Gly Thr  Glu Ser Thr Leu Trp  Gln Cys Arg 
    1325                 1330                 1335             


Asn Arg  Gly Trp Phe Ser His  Asn Cys Asn His Arg  Glu Asp Ala 
    1340                 1345                 1350             


Gly Val  Ile Cys Ser Gly Asn  His Leu Ser Thr Pro  Ala Pro Phe 
    1355                 1360                 1365             


Leu Asn  Ile Thr Arg Pro Asn  Thr Asp Tyr Ser Cys  Gly Gly Phe 
    1370                 1375                 1380             


Leu Ser  Gln Pro Ser Gly Asp  Phe Ser Ser Pro Phe  Tyr Pro Gly 
    1385                 1390                 1395             


Asn Tyr  Pro Asn Asn Ala Lys  Cys Val Trp Asp Ile  Glu Val Gln 
    1400                 1405                 1410             


Asn Asn  Tyr Arg Val Thr Val  Ile Phe Arg Asp Val  Gln Leu Glu 
    1415                 1420                 1425             


Gly Gly  Cys Asn Tyr Asp Tyr  Ile Glu Val Phe Asp  Gly Pro Tyr 
    1430                 1435                 1440             


Arg Ser  Ser Pro Leu Ile Ala  Arg Val Cys Asp Gly  Ala Arg Gly 
    1445                 1450                 1455             


Ser Phe  Thr Ser Ser Ser Asn  Phe Met Ser Ile Arg  Phe Ile Ser 
    1460                 1465                 1470             


Asp His  Ser Ile Thr Arg Arg  Gly Phe Arg Ala Glu  Tyr Tyr Ser 
    1475                 1480                 1485             


Ser Pro  Ser Asn Asp Ser Thr  Asn Leu Leu Cys Leu  Pro Asn His 
    1490                 1495                 1500             


Met Gln  Ala Ser Val Ser Arg  Ser Tyr Leu Gln Ser  Leu Gly Phe 
    1505                 1510                 1515             


Ser Ala  Ser Asp Leu Val Ile  Ser Thr Trp Asn Gly  Tyr Tyr Glu 
    1520                 1525                 1530             


Cys Arg  Pro Gln Ile Thr Pro  Asn Leu Val Ile Phe  Thr Ile Pro 
    1535                 1540                 1545             


Tyr Ser  Gly Cys Gly Thr Phe  Lys Gln Ala Asp Asn  Asp Thr Ile 
    1550                 1555                 1560             


Asp Tyr  Ser Asn Phe Leu Thr  Ala Ala Val Ser Gly  Gly Ile Ile 
    1565                 1570                 1575             


Lys Arg  Arg Thr Asp Leu Arg  Ile His Val Ser Cys  Arg Met Leu 
    1580                 1585                 1590             


Gln Asn  Thr Trp Val Asp Thr  Met Tyr Ile Ala Asn  Asp Thr Ile 
    1595                 1600                 1605             


His Val  Ala Asn Asn Thr Ile  Gln Val Glu Glu Val  Gln Tyr Gly 
    1610                 1615                 1620             


Asn Phe  Asp Val Asn Ile Ser  Phe Tyr Thr Ser Ser  Ser Phe Leu 
    1625                 1630                 1635             


Tyr Pro  Val Thr Ser Arg Pro  Tyr Tyr Val Asp Leu  Asn Gln Asp 
    1640                 1645                 1650             


Leu Tyr  Val Gln Ala Glu Ile  Leu His Ser Asp Ala  Val Leu Thr 
    1655                 1660                 1665             


Leu Phe  Val Asp Thr Cys Val  Ala Ser Pro Tyr Ser  Asn Asp Phe 
    1670                 1675                 1680             


Thr Ser  Leu Thr Tyr Asp Leu  Ile Arg Ser Gly Cys  Val Arg Asp 
    1685                 1690                 1695             


Asp Thr  Tyr Gly Pro Tyr Ser  Ser Pro Ser Leu Arg  Ile Ala Arg 
    1700                 1705                 1710             


Phe Arg  Phe Arg Ala Phe His  Phe Leu Asn Arg Phe  Pro Ser Val 
    1715                 1720                 1725             


Tyr Leu  Arg Cys Lys Met Val  Val Cys Arg Ala Tyr  Asp Pro Ser 
    1730                 1735                 1740             


Ser Arg  Cys Tyr Arg Gly Cys  Val Leu Arg Ser Lys  Arg Asp Val 
    1745                 1750                 1755             


Gly Ser  Tyr Gln Glu Lys Val  Asp Val Val Leu Gly  Pro Ile Gln 
    1760                 1765                 1770             


Leu Gln  Thr Pro Pro Arg Arg  Glu Glu Glu Pro Arg  
    1775                 1780                 1785 


<210>  98
<211>  2403
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Asp 
    450                 455                 460                 


Thr Leu Pro Thr Ile Thr Leu Pro Ala Ser Thr Val Gly Ser Glu Ser 
465                 470                 475                 480 


Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg 
                485                 490                 495     


Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser 
            500                 505                 510         


Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly 
        515                 520                 525             


Trp Ala Met Leu Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly 
    530                 535                 540                 


Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu 
545                 550                 555                 560 


Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His Ser 
                565                 570                 575     


Glu Asp Ala Gly Val Ile Cys Ser Gly Pro Glu Ser Ser Leu Ala Leu 
            580                 585                 590         


Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu 
        595                 600                 605             


Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn 
    610                 615                 620                 


Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser 
625                 630                 635                 640 


Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu 
                645                 650                 655     


Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro 
            660                 665                 670         


Asn Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly 
        675                 680                 685             


Val Ile Cys Ser Ala Ala Gln Ser Arg Ser Thr Pro Arg Pro Asp Thr 
    690                 695                 700                 


Leu Ser Thr Ile Thr Leu Pro Pro Ser Thr Val Gly Ser Glu Ser Ser 
705                 710                 715                 720 


Leu Thr Leu Arg Leu Val Asn Gly Ser Asp Arg Cys Gln Gly Arg Val 
                725                 730                 735     


Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp 
            740                 745                 750         


Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp 
        755                 760                 765             


Ala Thr Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro 
    770                 775                 780                 


Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp 
785                 790                 795                 800 


Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu 
                805                 810                 815     


Asp Ala Gly Val Ile Cys Ser Val Ser Gln Ser Arg Pro Thr Pro Ser 
            820                 825                 830         


Pro Asp Thr Trp Pro Thr Ser His Ala Ser Thr Ala Gly Pro Glu Ser 
        835                 840                 845             


Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg 
    850                 855                 860                 


Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser 
865                 870                 875                 880 


Trp Asp Thr Ser Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly 
                885                 890                 895     


Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly 
            900                 905                 910         


Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly Tyr Glu Ser Tyr Leu 
        915                 920                 925             


Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gln His Ser 
    930                 935                 940                 


Glu Asp Ala Gly Val Ile Cys Ser Ala Ala His Ser Trp Ser Thr Pro 
945                 950                 955                 960 


Ser Pro Asp Thr Leu Pro Thr Ile Thr Leu Pro Ala Ser Thr Val Gly 
                965                 970                 975     


Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys 
            980                 985                 990         


Gln Gly Arg Val Glu Val Leu Tyr  Gln Gly Ser Trp Gly  Thr Val Cys 
        995                 1000                 1005             


Asp Asp  Ser Trp Asp Thr Asn  Asp Ala Asn Val Val  Cys Arg Gln 
    1010                 1015                 1020             


Leu Gly  Cys Gly Trp Ala Met  Ser Ala Pro Gly Asn  Ala Arg Phe 
    1025                 1030                 1035             


Gly Gln  Gly Ser Gly Pro Ile  Val Leu Asp Asp Val  Arg Cys Ser 
    1040                 1045                 1050             


Gly His  Glu Ser Tyr Leu Trp  Ser Cys Pro His Asn  Gly Trp Leu 
    1055                 1060                 1065             


Ser His  Asn Cys Gly His Ser  Glu Asp Ala Gly Val  Ile Cys Ser 
    1070                 1075                 1080             


Ala Ser  Gln Ser Arg Pro Thr  Pro Ser Pro Asp Thr  Trp Pro Thr 
    1085                 1090                 1095             


Ser His  Ala Ser Thr Ala Gly  Ser Glu Ser Ser Leu  Ala Leu Arg 
    1100                 1105                 1110             


Leu Val  Asn Gly Gly Asp Arg  Cys Gln Gly Arg Val  Glu Val Leu 
    1115                 1120                 1125             


Tyr Arg  Gly Ser Trp Gly Thr  Val Cys Asp Asp Tyr  Trp Asp Thr 
    1130                 1135                 1140             


Asn Asp  Ala Asn Val Val Cys  Arg Gln Leu Gly Cys  Gly Trp Ala 
    1145                 1150                 1155             


Met Ser  Ala Pro Gly Asn Ala  Arg Phe Gly Gln Gly  Ser Gly Pro 
    1160                 1165                 1170             


Ile Val  Leu Asp Asp Val Arg  Cys Ser Gly His Glu  Ser Tyr Leu 
    1175                 1180                 1185             


Trp Ser  Cys Pro His Asn Gly  Trp Leu Ser His Asn  Cys Gly His 
    1190                 1195                 1200             


His Glu  Asp Ala Gly Val Ile  Cys Ser Ala Ser Gln  Ser Gln Pro 
    1205                 1210                 1215             


Thr Pro  Ser Pro Asp Thr Trp  Pro Thr Ser His Ala  Ser Thr Ala 
    1220                 1225                 1230             


Gly Ser  Glu Ser Ser Leu Ala  Leu Arg Leu Val Asn  Gly Gly Asp 
    1235                 1240                 1245             


Arg Cys  Gln Gly Arg Val Glu  Val Leu Tyr Arg Gly  Ser Trp Gly 
    1250                 1255                 1260             


Thr Val  Cys Asp Asp Tyr Trp  Asp Thr Asn Asp Ala  Asn Val Val 
    1265                 1270                 1275             


Cys Arg  Gln Leu Gly Cys Gly  Trp Ala Thr Ser Ala  Pro Gly Asn 
    1280                 1285                 1290             


Ala Arg  Phe Gly Gln Gly Ser  Gly Pro Ile Val Leu  Asp Asp Val 
    1295                 1300                 1305             


Arg Cys  Ser Gly His Glu Ser  Tyr Leu Trp Ser Cys  Pro His Asn 
    1310                 1315                 1320             


Gly Trp  Leu Ser His Asn Cys  Gly His His Glu Asp  Ala Gly Val 
    1325                 1330                 1335             


Ile Cys  Ser Ala Ser Gln Ser  Gln Pro Thr Pro Ser  Pro Asp Thr 
    1340                 1345                 1350             


Trp Pro  Thr Ser His Ala Ser  Thr Ala Gly Ser Glu  Ser Ser Leu 
    1355                 1360                 1365             


Ala Leu  Arg Leu Val Asn Gly  Gly Asp Arg Cys Gln  Gly Arg Val 
    1370                 1375                 1380             


Glu Val  Leu Tyr Arg Gly Ser  Trp Gly Thr Val Cys  Asp Asp Tyr 
    1385                 1390                 1395             


Trp Asp  Thr Asn Asp Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys 
    1400                 1405                 1410             


Gly Trp  Ala Thr Ser Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly 
    1415                 1420                 1425             


Ser Gly  Pro Ile Val Leu Asp  Asp Val Arg Cys Ser  Gly His Glu 
    1430                 1435                 1440             


Ser Tyr  Leu Trp Ser Cys Pro  His Asn Gly Trp Leu  Ser His Asn 
    1445                 1450                 1455             


Cys Gly  His His Glu Asp Ala  Gly Val Ile Cys Ser  Ala Ser Gln 
    1460                 1465                 1470             


Ser Gln  Pro Thr Pro Ser Pro  Asp Thr Trp Pro Thr  Ser Arg Ala 
    1475                 1480                 1485             


Ser Thr  Ala Gly Ser Glu Ser  Thr Leu Ala Leu Arg  Leu Val Asn 
    1490                 1495                 1500             


Gly Gly  Asp Arg Cys Arg Gly  Arg Val Glu Val Leu  Tyr Gln Gly 
    1505                 1510                 1515             


Ser Trp  Gly Thr Val Cys Asp  Asp Tyr Trp Asp Thr  Asn Asp Ala 
    1520                 1525                 1530             


Asn Val  Val Cys Arg Gln Leu  Gly Cys Gly Trp Ala  Met Ser Ala 
    1535                 1540                 1545             


Pro Gly  Asn Ala Gln Phe Gly  Gln Gly Ser Gly Pro  Ile Val Leu 
    1550                 1555                 1560             


Asp Asp  Val Arg Cys Ser Gly  His Glu Ser Tyr Leu  Trp Ser Cys 
    1565                 1570                 1575             


Pro His  Asn Gly Trp Leu Ser  His Asn Cys Gly His  His Glu Asp 
    1580                 1585                 1590             


Ala Gly  Val Ile Cys Ser Ala  Ala Gln Ser Gln Ser  Thr Pro Arg 
    1595                 1600                 1605             


Pro Asp  Thr Trp Leu Thr Thr  Asn Leu Pro Ala Leu  Thr Val Gly 
    1610                 1615                 1620             


Ser Glu  Ser Ser Leu Ala Leu  Arg Leu Val Asn Gly  Gly Asp Arg 
    1625                 1630                 1635             


Cys Arg  Gly Arg Val Glu Val  Leu Tyr Arg Gly Ser  Trp Gly Thr 
    1640                 1645                 1650             


Val Cys  Asp Asp Ser Trp Asp  Thr Asn Asp Ala Asn  Val Val Cys 
    1655                 1660                 1665             


Arg Gln  Leu Gly Cys Gly Trp  Ala Met Ser Ala Pro  Gly Asn Ala 
    1670                 1675                 1680             


Arg Phe  Gly Gln Gly Ser Gly  Pro Ile Val Leu Asp  Asp Val Arg 
    1685                 1690                 1695             


Cys Ser  Gly Asn Glu Ser Tyr  Leu Trp Ser Cys Pro  His Lys Gly 
    1700                 1705                 1710             


Trp Leu  Thr His Asn Cys Gly  His His Glu Asp Ala  Gly Val Ile 
    1715                 1720                 1725             


Cys Ser  Ala Thr Gln Ile Asn  Ser Thr Thr Thr Asp  Trp Trp His 
    1730                 1735                 1740             


Pro Thr  Thr Thr Thr Thr Ala  Arg Pro Ser Ser Asn  Cys Gly Gly 
    1745                 1750                 1755             


Phe Leu  Phe Tyr Ala Ser Gly  Thr Phe Ser Ser Pro  Ser Tyr Pro 
    1760                 1765                 1770             


Ala Tyr  Tyr Pro Asn Asn Ala  Lys Cys Val Trp Glu  Ile Glu Val 
    1775                 1780                 1785             


Asn Ser  Gly Tyr Arg Ile Asn  Leu Gly Phe Ser Asn  Leu Lys Leu 
    1790                 1795                 1800             


Glu Ala  His His Asn Cys Ser  Phe Asp Tyr Val Glu  Ile Phe Asp 
    1805                 1810                 1815             


Gly Ser  Leu Asn Ser Ser Leu  Leu Leu Gly Lys Ile  Cys Asn Asp 
    1820                 1825                 1830             


Thr Arg  Gln Ile Phe Thr Ser  Ser Tyr Asn Arg Met  Thr Ile His 
    1835                 1840                 1845             


Phe Arg  Ser Asp Ile Ser Phe  Gln Asn Thr Gly Phe  Leu Ala Trp 
    1850                 1855                 1860             


Tyr Asn  Ser Phe Pro Ser Asp  Ala Thr Leu Arg Leu  Val Asn Leu 
    1865                 1870                 1875             


Asn Ser  Ser Tyr Gly Leu Cys  Ala Gly Arg Val Glu  Ile Tyr His 
    1880                 1885                 1890             


Gly Gly  Thr Trp Gly Thr Val  Cys Asp Asp Ser Trp  Thr Ile Gln 
    1895                 1900                 1905             


Glu Ala  Glu Val Val Cys Arg  Gln Leu Gly Cys Gly  Arg Ala Val 
    1910                 1915                 1920             


Ser Ala  Leu Gly Asn Ala Tyr  Phe Gly Ser Gly Ser  Gly Pro Ile 
    1925                 1930                 1935             


Thr Leu  Asp Asp Val Glu Cys  Ser Gly Thr Glu Ser  Thr Leu Trp 
    1940                 1945                 1950             


Gln Cys  Arg Asn Arg Gly Trp  Phe Ser His Asn Cys  Asn His Arg 
    1955                 1960                 1965             


Glu Asp  Ala Gly Val Ile Cys  Ser Gly Asn His Leu  Ser Thr Pro 
    1970                 1975                 1980             


Ala Pro  Phe Leu Asn Ile Thr  Arg Pro Asn Thr Asp  Tyr Ser Cys 
    1985                 1990                 1995             


Gly Gly  Phe Leu Ser Gln Pro  Ser Gly Asp Phe Ser  Ser Pro Phe 
    2000                 2005                 2010             


Tyr Pro  Gly Asn Tyr Pro Asn  Asn Ala Lys Cys Val  Trp Asp Ile 
    2015                 2020                 2025             


Glu Val  Gln Asn Asn Tyr Arg  Val Thr Val Ile Phe  Arg Asp Val 
    2030                 2035                 2040             


Gln Leu  Glu Gly Gly Cys Asn  Tyr Asp Tyr Ile Glu  Val Phe Asp 
    2045                 2050                 2055             


Gly Pro  Tyr Arg Ser Ser Pro  Leu Ile Ala Arg Val  Cys Asp Gly 
    2060                 2065                 2070             


Ala Arg  Gly Ser Phe Thr Ser  Ser Ser Asn Phe Met  Ser Ile Arg 
    2075                 2080                 2085             


Phe Ile  Ser Asp His Ser Ile  Thr Arg Arg Gly Phe  Arg Ala Glu 
    2090                 2095                 2100             


Tyr Tyr  Ser Ser Pro Ser Asn  Asp Ser Thr Asn Leu  Leu Cys Leu 
    2105                 2110                 2115             


Pro Asn  His Met Gln Ala Ser  Val Ser Arg Ser Tyr  Leu Gln Ser 
    2120                 2125                 2130             


Leu Gly  Phe Ser Ala Ser Asp  Leu Val Ile Ser Thr  Trp Asn Gly 
    2135                 2140                 2145             


Tyr Tyr  Glu Cys Arg Pro Gln  Ile Thr Pro Asn Leu  Val Ile Phe 
    2150                 2155                 2160             


Thr Ile  Pro Tyr Ser Gly Cys  Gly Thr Phe Lys Gln  Ala Asp Asn 
    2165                 2170                 2175             


Asp Thr  Ile Asp Tyr Ser Asn  Phe Leu Thr Ala Ala  Val Ser Gly 
    2180                 2185                 2190             


Gly Ile  Ile Lys Arg Arg Thr  Asp Leu Arg Ile His  Val Ser Cys 
    2195                 2200                 2205             


Arg Met  Leu Gln Asn Thr Trp  Val Asp Thr Met Tyr  Ile Ala Asn 
    2210                 2215                 2220             


Asp Thr  Ile His Val Ala Asn  Asn Thr Ile Gln Val  Glu Glu Val 
    2225                 2230                 2235             


Gln Tyr  Gly Asn Phe Asp Val  Asn Ile Ser Phe Tyr  Thr Ser Ser 
    2240                 2245                 2250             


Ser Phe  Leu Tyr Pro Val Thr  Ser Arg Pro Tyr Tyr  Val Asp Leu 
    2255                 2260                 2265             


Asn Gln  Asp Leu Tyr Val Gln  Ala Glu Ile Leu His  Ser Asp Ala 
    2270                 2275                 2280             


Val Leu  Thr Leu Phe Val Asp  Thr Cys Val Ala Ser  Pro Tyr Ser 
    2285                 2290                 2295             


Asn Asp  Phe Thr Ser Leu Thr  Tyr Asp Leu Ile Arg  Ser Gly Cys 
    2300                 2305                 2310             


Val Arg  Asp Asp Thr Tyr Gly  Pro Tyr Ser Ser Pro  Ser Leu Arg 
    2315                 2320                 2325             


Ile Ala  Arg Phe Arg Phe Arg  Ala Phe His Phe Leu  Asn Arg Phe 
    2330                 2335                 2340             


Pro Ser  Val Tyr Leu Arg Cys  Lys Met Val Val Cys  Arg Ala Tyr 
    2345                 2350                 2355             


Asp Pro  Ser Ser Arg Cys Tyr  Arg Gly Cys Val Leu  Arg Ser Lys 
    2360                 2365                 2370             


Arg Asp  Val Gly Ser Tyr Gln  Glu Lys Val Asp Val  Val Leu Gly 
    2375                 2380                 2385             


Pro Ile  Gln Leu Gln Thr Pro  Pro Arg Arg Glu Glu  Glu Pro Arg 
    2390                 2395                 2400             


<210>  99
<211>  1527
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
    450                 455                 460                 


Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro Thr Ile Thr 
465                 470                 475                 480 


Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu 
                485                 490                 495     


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
            500                 505                 510         


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala 
        515                 520                 525             


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro 
    530                 535                 540                 


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
545                 550                 555                 560 


Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
                565                 570                 575     


Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly Val Ile 
            580                 585                 590         


Cys Ser Ala Ser Gln Ser Gln Pro Thr Pro Ser Pro Asp Thr Trp Pro 
        595                 600                 605             


Thr Ser Arg Ala Ser Thr Ala Gly Ser Glu Ser Thr Leu Ala Leu Arg 
    610                 615                 620                 


Leu Val Asn Gly Gly Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr 
625                 630                 635                 640 


Gln Gly Ser Trp Gly Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp 
                645                 650                 655     


Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala 
            660                 665                 670         


Pro Gly Asn Ala Gln Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp 
        675                 680                 685             


Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His 
    690                 695                 700                 


Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly Val 
705                 710                 715                 720 


Ile Cys Ser Ala Ala Gln Ser Gln Ser Thr Pro Arg Pro Asp Thr Trp 
                725                 730                 735     


Leu Thr Thr Asn Leu Pro Ala Leu Thr Val Gly Ser Glu Ser Ser Leu 
            740                 745                 750         


Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Arg Gly Arg Val Glu 
        755                 760                 765             


Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp 
    770                 775                 780                 


Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala 
785                 790                 795                 800 


Met Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile 
                805                 810                 815     


Val Leu Asp Asp Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu Trp Ser 
            820                 825                 830         


Cys Pro His Lys Gly Trp Leu Thr His Asn Cys Gly His His Glu Asp 
        835                 840                 845             


Ala Gly Val Ile Cys Ser Ala Thr Gln Ile Asn Ser Thr Thr Thr Asp 
    850                 855                 860                 


Trp Trp His Pro Thr Thr Thr Thr Thr Ala Arg Pro Ser Ser Asn Cys 
865                 870                 875                 880 


Gly Gly Phe Leu Phe Tyr Ala Ser Gly Thr Phe Ser Ser Pro Ser Tyr 
                885                 890                 895     


Pro Ala Tyr Tyr Pro Asn Asn Ala Lys Cys Val Trp Glu Ile Glu Val 
            900                 905                 910         


Asn Ser Gly Tyr Arg Ile Asn Leu Gly Phe Ser Asn Leu Lys Leu Glu 
        915                 920                 925             


Ala His His Asn Cys Ser Phe Asp Tyr Val Glu Ile Phe Asp Gly Ser 
    930                 935                 940                 


Leu Asn Ser Ser Leu Leu Leu Gly Lys Ile Cys Asn Asp Thr Arg Gln 
945                 950                 955                 960 


Ile Phe Thr Ser Ser Tyr Asn Arg Met Thr Ile His Phe Arg Ser Asp 
                965                 970                 975     


Ile Ser Phe Gln Asn Thr Gly Phe Leu Ala Trp Tyr Asn Ser Phe Pro 
            980                 985                 990         


Ser Asp Ala Thr Leu Arg Leu Val  Asn Leu Asn Ser Ser  Tyr Gly Leu 
        995                 1000                 1005             


Cys Ala  Gly Arg Val Glu Ile  Tyr His Gly Gly Thr  Trp Gly Thr 
    1010                 1015                 1020             


Val Cys  Asp Asp Ser Trp Thr  Ile Gln Glu Ala Glu  Val Val Cys 
    1025                 1030                 1035             


Arg Gln  Leu Gly Cys Gly Arg  Ala Val Ser Ala Leu  Gly Asn Ala 
    1040                 1045                 1050             


Tyr Phe  Gly Ser Gly Ser Gly  Pro Ile Thr Leu Asp  Asp Val Glu 
    1055                 1060                 1065             


Cys Ser  Gly Thr Glu Ser Thr  Leu Trp Gln Cys Arg  Asn Arg Gly 
    1070                 1075                 1080             


Trp Phe  Ser His Asn Cys Asn  His Arg Glu Asp Ala  Gly Val Ile 
    1085                 1090                 1095             


Cys Ser  Gly Asn His Leu Ser  Thr Pro Ala Pro Phe  Leu Asn Ile 
    1100                 1105                 1110             


Thr Arg  Pro Asn Thr Asp Tyr  Ser Cys Gly Gly Phe  Leu Ser Gln 
    1115                 1120                 1125             


Pro Ser  Gly Asp Phe Ser Ser  Pro Phe Tyr Pro Gly  Asn Tyr Pro 
    1130                 1135                 1140             


Asn Asn  Ala Lys Cys Val Trp  Asp Ile Glu Val Gln  Asn Asn Tyr 
    1145                 1150                 1155             


Arg Val  Thr Val Ile Phe Arg  Asp Val Gln Leu Glu  Gly Gly Cys 
    1160                 1165                 1170             


Asn Tyr  Asp Tyr Ile Glu Val  Phe Asp Gly Pro Tyr  Arg Ser Ser 
    1175                 1180                 1185             


Pro Leu  Ile Ala Arg Val Cys  Asp Gly Ala Arg Gly  Ser Phe Thr 
    1190                 1195                 1200             


Ser Ser  Ser Asn Phe Met Ser  Ile Arg Phe Ile Ser  Asp His Ser 
    1205                 1210                 1215             


Ile Thr  Arg Arg Gly Phe Arg  Ala Glu Tyr Tyr Ser  Ser Pro Ser 
    1220                 1225                 1230             


Asn Asp  Ser Thr Asn Leu Leu  Cys Leu Pro Asn His  Met Gln Ala 
    1235                 1240                 1245             


Ser Val  Ser Arg Ser Tyr Leu  Gln Ser Leu Gly Phe  Ser Ala Ser 
    1250                 1255                 1260             


Asp Leu  Val Ile Ser Thr Trp  Asn Gly Tyr Tyr Glu  Cys Arg Pro 
    1265                 1270                 1275             


Gln Ile  Thr Pro Asn Leu Val  Ile Phe Thr Ile Pro  Tyr Ser Gly 
    1280                 1285                 1290             


Cys Gly  Thr Phe Lys Gln Ala  Asp Asn Asp Thr Ile  Asp Tyr Ser 
    1295                 1300                 1305             


Asn Phe  Leu Thr Ala Ala Val  Ser Gly Gly Ile Ile  Lys Arg Arg 
    1310                 1315                 1320             


Thr Asp  Leu Arg Ile His Val  Ser Cys Arg Met Leu  Gln Asn Thr 
    1325                 1330                 1335             


Trp Val  Asp Thr Met Tyr Ile  Ala Asn Asp Thr Ile  His Val Ala 
    1340                 1345                 1350             


Asn Asn  Thr Ile Gln Val Glu  Glu Val Gln Tyr Gly  Asn Phe Asp 
    1355                 1360                 1365             


Val Asn  Ile Ser Phe Tyr Thr  Ser Ser Ser Phe Leu  Tyr Pro Val 
    1370                 1375                 1380             


Thr Ser  Arg Pro Tyr Tyr Val  Asp Leu Asn Gln Asp  Leu Tyr Val 
    1385                 1390                 1395             


Gln Ala  Glu Ile Leu His Ser  Asp Ala Val Leu Thr  Leu Phe Val 
    1400                 1405                 1410             


Asp Thr  Cys Val Ala Ser Pro  Tyr Ser Asn Asp Phe  Thr Ser Leu 
    1415                 1420                 1425             


Thr Tyr  Asp Leu Ile Arg Ser  Gly Cys Val Arg Asp  Asp Thr Tyr 
    1430                 1435                 1440             


Gly Pro  Tyr Ser Ser Pro Ser  Leu Arg Ile Ala Arg  Phe Arg Phe 
    1445                 1450                 1455             


Arg Ala  Phe His Phe Leu Asn  Arg Phe Pro Ser Val  Tyr Leu Arg 
    1460                 1465                 1470             


Cys Lys  Met Val Val Cys Arg  Ala Tyr Asp Pro Ser  Ser Arg Cys 
    1475                 1480                 1485             


Tyr Arg  Gly Cys Val Leu Arg  Ser Lys Arg Asp Val  Gly Ser Tyr 
    1490                 1495                 1500             


Gln Glu  Lys Val Asp Val Val  Leu Gly Pro Ile Gln  Leu Gln Thr 
    1505                 1510                 1515             


Pro Pro  Arg Arg Glu Glu Glu  Pro Arg 
    1520                 1525         


<210>  100
<211>  2542
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
    450                 455                 460                 


Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro Thr Ile Thr 
465                 470                 475                 480 


Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu 
                485                 490                 495     


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
            500                 505                 510         


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala 
        515                 520                 525             


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Leu Ala Pro 
    530                 535                 540                 


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
545                 550                 555                 560 


Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
                565                 570                 575     


Gly Trp Leu Ser His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile 
            580                 585                 590         


Cys Ser Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
        595                 600                 605             


Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
    610                 615                 620                 


Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
625                 630                 635                 640 


Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg 
                645                 650                 655     


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
            660                 665                 670         


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro Asn Asn Gly Trp Leu Ser 
        675                 680                 685             


His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Ala 
    690                 695                 700                 


Gln Ser Arg Ser Thr Pro Arg Pro Asp Thr Leu Ser Thr Ile Thr Leu 
705                 710                 715                 720 


Pro Pro Ser Thr Val Gly Ser Glu Ser Ser Leu Thr Leu Arg Leu Val 
                725                 730                 735     


Asn Gly Ser Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly 
            740                 745                 750         


Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn 
        755                 760                 765             


Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly 
    770                 775                 780                 


Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val 
785                 790                 795                 800 


Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly 
                805                 810                 815     


Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys 
            820                 825                 830         


Ser Val Ser Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr 
        835                 840                 845             


Ser His Ala Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu 
    850                 855                 860                 


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
865                 870                 875                 880 


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala 
                885                 890                 895     


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro 
            900                 905                 910         


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
        915                 920                 925             


Val Arg Cys Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
    930                 935                 940                 


Gly Trp Leu Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile 
945                 950                 955                 960 


Cys Ser Ala Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro 
                965                 970                 975     


Thr Ile Thr Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala 
            980                 985                 990         


Leu Arg Leu Val Asn Gly Gly Asp  Arg Cys Gln Gly Arg  Val Glu Val 
        995                 1000                 1005             


Leu Tyr  Gln Gly Ser Trp Gly  Thr Val Cys Asp Asp  Ser Trp Asp 
    1010                 1015                 1020             


Thr Asn  Asp Ala Asn Val Val  Cys Arg Gln Leu Gly  Cys Gly Trp 
    1025                 1030                 1035             


Ala Met  Ser Ala Pro Gly Asn  Ala Arg Phe Gly Gln  Gly Ser Gly 
    1040                 1045                 1050             


Pro Ile  Val Leu Asp Asp Val  Arg Cys Ser Gly His  Glu Ser Tyr 
    1055                 1060                 1065             


Leu Trp  Ser Cys Pro His Asn  Gly Trp Leu Ser His  Asn Cys Gly 
    1070                 1075                 1080             


His Ser  Glu Asp Ala Gly Val  Ile Cys Ser Ala Ser  Gln Ser Arg 
    1085                 1090                 1095             


Pro Thr  Pro Ser Pro Asp Thr  Trp Pro Thr Ser His  Ala Ser Thr 
    1100                 1105                 1110             


Ala Gly  Ser Glu Ser Ser Leu  Ala Leu Arg Leu Val  Asn Gly Gly 
    1115                 1120                 1125             


Asp Arg  Cys Gln Gly Arg Val  Glu Val Leu Tyr Arg  Gly Ser Trp 
    1130                 1135                 1140             


Gly Thr  Val Cys Asp Asp Tyr  Trp Asp Thr Asn Asp  Ala Asn Val 
    1145                 1150                 1155             


Val Cys  Arg Gln Leu Gly Cys  Gly Trp Ala Met Ser  Ala Pro Gly 
    1160                 1165                 1170             


Asn Ala  Arg Phe Gly Gln Gly  Ser Gly Pro Ile Val  Leu Asp Asp 
    1175                 1180                 1185             


Val Arg  Cys Ser Gly His Glu  Ser Tyr Leu Trp Ser  Cys Pro His 
    1190                 1195                 1200             


Asn Gly  Trp Leu Ser His Asn  Cys Gly His His Glu  Asp Ala Gly 
    1205                 1210                 1215             


Val Ile  Cys Ser Ala Ser Gln  Ser Gln Pro Thr Pro  Ser Pro Asp 
    1220                 1225                 1230             


Thr Trp  Pro Thr Ser His Ala  Ser Thr Ala Gly Ser  Glu Ser Ser 
    1235                 1240                 1245             


Leu Ala  Leu Arg Leu Val Asn  Gly Gly Asp Arg Cys  Gln Gly Arg 
    1250                 1255                 1260             


Val Glu  Val Leu Tyr Arg Gly  Ser Trp Gly Thr Val  Cys Asp Asp 
    1265                 1270                 1275             


Tyr Trp  Asp Thr Asn Asp Ala  Asn Val Val Cys Arg  Gln Leu Gly 
    1280                 1285                 1290             


Cys Gly  Trp Ala Thr Ser Ala  Pro Gly Asn Ala Arg  Phe Gly Gln 
    1295                 1300                 1305             


Gly Ser  Gly Pro Ile Val Leu  Asp Asp Val Arg Cys  Ser Gly His 
    1310                 1315                 1320             


Glu Ser  Tyr Leu Trp Ser Cys  Pro His Asn Gly Trp  Leu Ser His 
    1325                 1330                 1335             


Asn Cys  Gly His His Glu Asp  Ala Gly Val Ile Cys  Ser Ala Ser 
    1340                 1345                 1350             


Gln Ser  Gln Pro Thr Pro Ser  Pro Asp Thr Trp Pro  Thr Ser His 
    1355                 1360                 1365             


Ala Ser  Thr Ala Gly Ser Glu  Ser Ser Leu Ala Leu  Arg Leu Val 
    1370                 1375                 1380             


Asn Gly  Gly Asp Arg Cys Gln  Gly Arg Val Glu Val  Leu Tyr Arg 
    1385                 1390                 1395             


Gly Ser  Trp Gly Thr Val Cys  Asp Asp Tyr Trp Asp  Thr Asn Asp 
    1400                 1405                 1410             


Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys Gly Trp  Ala Thr Ser 
    1415                 1420                 1425             


Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly Ser Gly  Pro Ile Val 
    1430                 1435                 1440             


Leu Asp  Asp Val Arg Cys Ser  Gly His Glu Ser Tyr  Leu Trp Ser 
    1445                 1450                 1455             


Cys Pro  His Asn Gly Trp Leu  Ser His Asn Cys Gly  His His Glu 
    1460                 1465                 1470             


Asp Ala  Gly Val Ile Cys Ser  Ala Ser Gln Ser Gln  Pro Thr Pro 
    1475                 1480                 1485             


Ser Pro  Asp Thr Trp Pro Thr  Ser His Ala Ser Thr  Ala Gly Ser 
    1490                 1495                 1500             


Glu Ser  Ser Leu Ala Leu Arg  Leu Val Asn Gly Gly  Asp Arg Cys 
    1505                 1510                 1515             


Gln Gly  Arg Val Glu Val Leu  Tyr Arg Gly Ser Trp  Gly Thr Val 
    1520                 1525                 1530             


Cys Asp  Asp Tyr Trp Asp Thr  Asn Asp Ala Asn Val  Val Cys Arg 
    1535                 1540                 1545             


Gln Leu  Gly Cys Gly Trp Ala  Thr Ser Ala Pro Gly  Asn Ala Arg 
    1550                 1555                 1560             


Phe Gly  Gln Gly Ser Gly Pro  Ile Val Leu Asp Asp  Val Arg Cys 
    1565                 1570                 1575             


Ser Gly  His Glu Ser Tyr Leu  Trp Ser Cys Pro His  Asn Gly Trp 
    1580                 1585                 1590             


Leu Ser  His Asn Cys Gly His  His Glu Asp Ala Gly  Val Ile Cys 
    1595                 1600                 1605             


Ser Ala  Ser Gln Ser Gln Pro  Thr Pro Ser Pro Asp  Thr Trp Pro 
    1610                 1615                 1620             


Thr Ser  Arg Ala Ser Thr Ala  Gly Ser Glu Ser Thr  Leu Ala Leu 
    1625                 1630                 1635             


Arg Leu  Val Asn Gly Gly Asp  Arg Cys Arg Gly Arg  Val Glu Val 
    1640                 1645                 1650             


Leu Tyr  Gln Gly Ser Trp Gly  Thr Val Cys Asp Asp  Tyr Trp Asp 
    1655                 1660                 1665             


Thr Asn  Asp Ala Asn Val Val  Cys Arg Gln Leu Gly  Cys Gly Trp 
    1670                 1675                 1680             


Ala Met  Ser Ala Pro Gly Asn  Ala Gln Phe Gly Gln  Gly Ser Gly 
    1685                 1690                 1695             


Pro Ile  Val Leu Asp Asp Val  Arg Cys Ser Gly His  Glu Ser Tyr 
    1700                 1705                 1710             


Leu Trp  Ser Cys Pro His Asn  Gly Trp Leu Ser His  Asn Cys Gly 
    1715                 1720                 1725             


His His  Glu Asp Ala Gly Val  Ile Cys Ser Ala Ala  Gln Ser Gln 
    1730                 1735                 1740             


Ser Thr  Pro Arg Pro Asp Thr  Trp Leu Thr Thr Asn  Leu Pro Ala 
    1745                 1750                 1755             


Leu Thr  Val Gly Ser Glu Ser  Ser Leu Ala Leu Arg  Leu Val Asn 
    1760                 1765                 1770             


Gly Gly  Asp Arg Cys Arg Gly  Arg Val Glu Val Leu  Tyr Arg Gly 
    1775                 1780                 1785             


Ser Trp  Gly Thr Val Cys Asp  Asp Ser Trp Asp Thr  Asn Asp Ala 
    1790                 1795                 1800             


Asn Val  Val Cys Arg Gln Leu  Gly Cys Gly Trp Ala  Met Ser Ala 
    1805                 1810                 1815             


Pro Gly  Asn Ala Arg Phe Gly  Gln Gly Ser Gly Pro  Ile Val Leu 
    1820                 1825                 1830             


Asp Asp  Val Arg Cys Ser Gly  Asn Glu Ser Tyr Leu  Trp Ser Cys 
    1835                 1840                 1845             


Pro His  Lys Gly Trp Leu Thr  His Asn Cys Gly His  His Glu Asp 
    1850                 1855                 1860             


Ala Gly  Val Ile Cys Ser Ala  Thr Gln Ile Asn Ser  Thr Thr Thr 
    1865                 1870                 1875             


Asp Trp  Trp His Pro Thr Thr  Thr Thr Thr Ala Arg  Pro Ser Ser 
    1880                 1885                 1890             


Asn Cys  Gly Gly Phe Leu Phe  Tyr Ala Ser Gly Thr  Phe Ser Ser 
    1895                 1900                 1905             


Pro Ser  Tyr Pro Ala Tyr Tyr  Pro Asn Asn Ala Lys  Cys Val Trp 
    1910                 1915                 1920             


Glu Ile  Glu Val Asn Ser Gly  Tyr Arg Ile Asn Leu  Gly Phe Ser 
    1925                 1930                 1935             


Asn Leu  Lys Leu Glu Ala His  His Asn Cys Ser Phe  Asp Tyr Val 
    1940                 1945                 1950             


Glu Ile  Phe Asp Gly Ser Leu  Asn Ser Ser Leu Leu  Leu Gly Lys 
    1955                 1960                 1965             


Ile Cys  Asn Asp Thr Arg Gln  Ile Phe Thr Ser Ser  Tyr Asn Arg 
    1970                 1975                 1980             


Met Thr  Ile His Phe Arg Ser  Asp Ile Ser Phe Gln  Asn Thr Gly 
    1985                 1990                 1995             


Phe Leu  Ala Trp Tyr Asn Ser  Phe Pro Ser Asp Ala  Thr Leu Arg 
    2000                 2005                 2010             


Leu Val  Asn Leu Asn Ser Ser  Tyr Gly Leu Cys Ala  Gly Arg Val 
    2015                 2020                 2025             


Glu Ile  Tyr His Gly Gly Thr  Trp Gly Thr Val Cys  Asp Asp Ser 
    2030                 2035                 2040             


Trp Thr  Ile Gln Glu Ala Glu  Val Val Cys Arg Gln  Leu Gly Cys 
    2045                 2050                 2055             


Gly Arg  Ala Val Ser Ala Leu  Gly Asn Ala Tyr Phe  Gly Ser Gly 
    2060                 2065                 2070             


Ser Gly  Pro Ile Thr Leu Asp  Asp Val Glu Cys Ser  Gly Thr Glu 
    2075                 2080                 2085             


Ser Thr  Leu Trp Gln Cys Arg  Asn Arg Gly Trp Phe  Ser His Asn 
    2090                 2095                 2100             


Cys Asn  His Arg Glu Asp Ala  Gly Val Ile Cys Ser  Gly Asn His 
    2105                 2110                 2115             


Leu Ser  Thr Pro Ala Pro Phe  Leu Asn Ile Thr Arg  Pro Asn Thr 
    2120                 2125                 2130             


Asp Tyr  Ser Cys Gly Gly Phe  Leu Ser Gln Pro Ser  Gly Asp Phe 
    2135                 2140                 2145             


Ser Ser  Pro Phe Tyr Pro Gly  Asn Tyr Pro Asn Asn  Ala Lys Cys 
    2150                 2155                 2160             


Val Trp  Asp Ile Glu Val Gln  Asn Asn Tyr Arg Val  Thr Val Ile 
    2165                 2170                 2175             


Phe Arg  Asp Val Gln Leu Glu  Gly Gly Cys Asn Tyr  Asp Tyr Ile 
    2180                 2185                 2190             


Glu Val  Phe Asp Gly Pro Tyr  Arg Ser Ser Pro Leu  Ile Ala Arg 
    2195                 2200                 2205             


Val Cys  Asp Gly Ala Arg Gly  Ser Phe Thr Ser Ser  Ser Asn Phe 
    2210                 2215                 2220             


Met Ser  Ile Arg Phe Ile Ser  Asp His Ser Ile Thr  Arg Arg Gly 
    2225                 2230                 2235             


Phe Arg  Ala Glu Tyr Tyr Ser  Ser Pro Ser Asn Asp  Ser Thr Asn 
    2240                 2245                 2250             


Leu Leu  Cys Leu Pro Asn His  Met Gln Ala Ser Val  Ser Arg Ser 
    2255                 2260                 2265             


Tyr Leu  Gln Ser Leu Gly Phe  Ser Ala Ser Asp Leu  Val Ile Ser 
    2270                 2275                 2280             


Thr Trp  Asn Gly Tyr Tyr Glu  Cys Arg Pro Gln Ile  Thr Pro Asn 
    2285                 2290                 2295             


Leu Val  Ile Phe Thr Ile Pro  Tyr Ser Gly Cys Gly  Thr Phe Lys 
    2300                 2305                 2310             


Gln Ala  Asp Asn Asp Thr Ile  Asp Tyr Ser Asn Phe  Leu Thr Ala 
    2315                 2320                 2325             


Ala Val  Ser Gly Gly Ile Ile  Lys Arg Arg Thr Asp  Leu Arg Ile 
    2330                 2335                 2340             


His Val  Ser Cys Arg Met Leu  Gln Asn Thr Trp Val  Asp Thr Met 
    2345                 2350                 2355             


Tyr Ile  Ala Asn Asp Thr Ile  His Val Ala Asn Asn  Thr Ile Gln 
    2360                 2365                 2370             


Val Glu  Glu Val Gln Tyr Gly  Asn Phe Asp Val Asn  Ile Ser Phe 
    2375                 2380                 2385             


Tyr Thr  Ser Ser Ser Phe Leu  Tyr Pro Val Thr Ser  Arg Pro Tyr 
    2390                 2395                 2400             


Tyr Val  Asp Leu Asn Gln Asp  Leu Tyr Val Gln Ala  Glu Ile Leu 
    2405                 2410                 2415             


His Ser  Asp Ala Val Leu Thr  Leu Phe Val Asp Thr  Cys Val Ala 
    2420                 2425                 2430             


Ser Pro  Tyr Ser Asn Asp Phe  Thr Ser Leu Thr Tyr  Asp Leu Ile 
    2435                 2440                 2445             


Arg Ser  Gly Cys Val Arg Asp  Asp Thr Tyr Gly Pro  Tyr Ser Ser 
    2450                 2455                 2460             


Pro Ser  Leu Arg Ile Ala Arg  Phe Arg Phe Arg Ala  Phe His Phe 
    2465                 2470                 2475             


Leu Asn  Arg Phe Pro Ser Val  Tyr Leu Arg Cys Lys  Met Val Val 
    2480                 2485                 2490             


Cys Arg  Ala Tyr Asp Pro Ser  Ser Arg Cys Tyr Arg  Gly Cys Val 
    2495                 2500                 2505             


Leu Arg  Ser Lys Arg Asp Val  Gly Ser Tyr Gln Glu  Lys Val Asp 
    2510                 2515                 2520             


Val Val  Leu Gly Pro Ile Gln  Leu Gln Thr Pro Pro  Arg Arg Glu 
    2525                 2530                 2535             


Glu Glu  Pro Arg 
    2540         


<210>  101
<211>  2532
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Asp 
    450                 455                 460                 


Thr Leu Pro Thr Ile Thr Leu Pro Ala Ser Thr Val Gly Ser Glu Ser 
465                 470                 475                 480 


Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg 
                485                 490                 495     


Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser 
            500                 505                 510         


Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly 
        515                 520                 525             


Trp Ala Met Leu Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly 
    530                 535                 540                 


Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu 
545                 550                 555                 560 


Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His Ser 
                565                 570                 575     


Glu Asp Ala Gly Val Ile Cys Ser Gly Pro Glu Ser Ser Leu Ala Leu 
            580                 585                 590         


Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu 
        595                 600                 605             


Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn 
    610                 615                 620                 


Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser 
625                 630                 635                 640 


Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu 
                645                 650                 655     


Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro 
            660                 665                 670         


Asn Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly 
        675                 680                 685             


Val Ile Cys Ser Ala Ala Gln Ser Arg Ser Thr Pro Arg Pro Asp Thr 
    690                 695                 700                 


Leu Ser Thr Ile Thr Leu Pro Pro Ser Thr Val Gly Ser Glu Ser Ser 
705                 710                 715                 720 


Leu Thr Leu Arg Leu Val Asn Gly Ser Asp Arg Cys Gln Gly Arg Val 
                725                 730                 735     


Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp 
            740                 745                 750         


Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp 
        755                 760                 765             


Ala Thr Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro 
    770                 775                 780                 


Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu Trp 
785                 790                 795                 800 


Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His His Glu 
                805                 810                 815     


Asp Ala Gly Val Ile Cys Ser Val Ser Gln Ser Arg Pro Thr Pro Ser 
            820                 825                 830         


Pro Asp Thr Trp Pro Thr Ser His Ala Ser Thr Ala Gly Pro Glu Ser 
        835                 840                 845             


Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg 
    850                 855                 860                 


Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp Ser 
865                 870                 875                 880 


Trp Asp Thr Ser Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly 
                885                 890                 895     


Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly 
            900                 905                 910         


Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly Tyr Glu Ser Tyr Leu 
        915                 920                 925             


Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gln His Ser 
    930                 935                 940                 


Glu Asp Ala Gly Val Ile Cys Ser Ala Ala His Ser Trp Ser Thr Pro 
945                 950                 955                 960 


Ser Pro Asp Thr Leu Pro Thr Ile Thr Leu Pro Ala Ser Thr Val Gly 
                965                 970                 975     


Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys 
            980                 985                 990         


Gln Gly Arg Val Glu Val Leu Tyr  Gln Gly Ser Trp Gly  Thr Val Cys 
        995                 1000                 1005             


Asp Asp  Ser Trp Asp Thr Asn  Asp Ala Asn Val Val  Cys Arg Gln 
    1010                 1015                 1020             


Leu Gly  Cys Gly Trp Ala Met  Ser Ala Pro Gly Asn  Ala Arg Phe 
    1025                 1030                 1035             


Gly Gln  Gly Ser Gly Pro Ile  Val Leu Asp Asp Val  Arg Cys Ser 
    1040                 1045                 1050             


Gly His  Glu Ser Tyr Leu Trp  Ser Cys Pro His Asn  Gly Trp Leu 
    1055                 1060                 1065             


Ser His  Asn Cys Gly His Ser  Glu Asp Ala Gly Val  Ile Cys Ser 
    1070                 1075                 1080             


Ala Ser  Gln Ser Arg Pro Thr  Pro Ser Pro Asp Thr  Trp Pro Thr 
    1085                 1090                 1095             


Ser His  Ala Ser Thr Ala Gly  Ser Glu Ser Ser Leu  Ala Leu Arg 
    1100                 1105                 1110             


Leu Val  Asn Gly Gly Asp Arg  Cys Gln Gly Arg Val  Glu Val Leu 
    1115                 1120                 1125             


Tyr Arg  Gly Ser Trp Gly Thr  Val Cys Asp Asp Tyr  Trp Asp Thr 
    1130                 1135                 1140             


Asn Asp  Ala Asn Val Val Cys  Arg Gln Leu Gly Cys  Gly Trp Ala 
    1145                 1150                 1155             


Met Ser  Ala Pro Gly Asn Ala  Arg Phe Gly Gln Gly  Ser Gly Pro 
    1160                 1165                 1170             


Ile Val  Leu Asp Asp Val Arg  Cys Ser Gly His Glu  Ser Tyr Leu 
    1175                 1180                 1185             


Trp Ser  Cys Pro His Asn Gly  Trp Leu Ser His Asn  Cys Gly His 
    1190                 1195                 1200             


His Glu  Asp Ala Gly Val Ile  Cys Ser Ala Ser Gln  Ser Gln Pro 
    1205                 1210                 1215             


Thr Pro  Ser Pro Asp Thr Trp  Pro Thr Ser His Ala  Ser Thr Ala 
    1220                 1225                 1230             


Gly Ser  Glu Ser Ser Leu Ala  Leu Arg Leu Val Asn  Gly Gly Asp 
    1235                 1240                 1245             


Arg Cys  Gln Gly Arg Val Glu  Val Leu Tyr Arg Gly  Ser Trp Gly 
    1250                 1255                 1260             


Thr Val  Cys Asp Asp Tyr Trp  Asp Thr Asn Asp Ala  Asn Val Val 
    1265                 1270                 1275             


Cys Arg  Gln Leu Gly Cys Gly  Trp Ala Thr Ser Ala  Pro Gly Asn 
    1280                 1285                 1290             


Ala Arg  Phe Gly Gln Gly Ser  Gly Pro Ile Val Leu  Asp Asp Val 
    1295                 1300                 1305             


Arg Cys  Ser Gly His Glu Ser  Tyr Leu Trp Ser Cys  Pro His Asn 
    1310                 1315                 1320             


Gly Trp  Leu Ser His Asn Cys  Gly His His Glu Asp  Ala Gly Val 
    1325                 1330                 1335             


Ile Cys  Ser Ala Ser Gln Ser  Gln Pro Thr Pro Ser  Pro Asp Thr 
    1340                 1345                 1350             


Trp Pro  Thr Ser His Ala Ser  Thr Ala Gly Ser Glu  Ser Ser Leu 
    1355                 1360                 1365             


Ala Leu  Arg Leu Val Asn Gly  Gly Asp Arg Cys Gln  Gly Arg Val 
    1370                 1375                 1380             


Glu Val  Leu Tyr Arg Gly Ser  Trp Gly Thr Val Cys  Asp Asp Tyr 
    1385                 1390                 1395             


Trp Asp  Thr Asn Asp Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys 
    1400                 1405                 1410             


Gly Trp  Ala Thr Ser Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly 
    1415                 1420                 1425             


Ser Gly  Pro Ile Val Leu Asp  Asp Val Arg Cys Ser  Gly His Glu 
    1430                 1435                 1440             


Ser Tyr  Leu Trp Ser Cys Pro  His Asn Gly Trp Leu  Ser His Asn 
    1445                 1450                 1455             


Cys Gly  His His Glu Asp Ala  Gly Val Ile Cys Ser  Ala Ser Gln 
    1460                 1465                 1470             


Ser Gln  Pro Thr Pro Ser Pro  Asp Thr Trp Pro Thr  Ser His Ala 
    1475                 1480                 1485             


Ser Thr  Ala Gly Ser Glu Ser  Ser Leu Ala Leu Arg  Leu Val Asn 
    1490                 1495                 1500             


Gly Gly  Asp Arg Cys Gln Gly  Arg Val Glu Val Leu  Tyr Arg Gly 
    1505                 1510                 1515             


Ser Trp  Gly Thr Val Cys Asp  Asp Tyr Trp Asp Thr  Asn Asp Ala 
    1520                 1525                 1530             


Asn Val  Val Cys Arg Gln Leu  Gly Cys Gly Trp Ala  Thr Ser Ala 
    1535                 1540                 1545             


Pro Gly  Asn Ala Arg Phe Gly  Gln Gly Ser Gly Pro  Ile Val Leu 
    1550                 1555                 1560             


Asp Asp  Val Arg Cys Ser Gly  His Glu Ser Tyr Leu  Trp Ser Cys 
    1565                 1570                 1575             


Pro His  Asn Gly Trp Leu Ser  His Asn Cys Gly His  His Glu Asp 
    1580                 1585                 1590             


Ala Gly  Val Ile Cys Ser Ala  Ser Gln Ser Gln Pro  Thr Pro Ser 
    1595                 1600                 1605             


Pro Asp  Thr Trp Pro Thr Ser  Arg Ala Ser Thr Ala  Gly Ser Glu 
    1610                 1615                 1620             


Ser Thr  Leu Ala Leu Arg Leu  Val Asn Gly Gly Asp  Arg Cys Arg 
    1625                 1630                 1635             


Gly Arg  Val Glu Val Leu Tyr  Gln Gly Ser Trp Gly  Thr Val Cys 
    1640                 1645                 1650             


Asp Asp  Tyr Trp Asp Thr Asn  Asp Ala Asn Val Val  Cys Arg Gln 
    1655                 1660                 1665             


Leu Gly  Cys Gly Trp Ala Met  Ser Ala Pro Gly Asn  Ala Gln Phe 
    1670                 1675                 1680             


Gly Gln  Gly Ser Gly Pro Ile  Val Leu Asp Asp Val  Arg Cys Ser 
    1685                 1690                 1695             


Gly His  Glu Ser Tyr Leu Trp  Ser Cys Pro His Asn  Gly Trp Leu 
    1700                 1705                 1710             


Ser His  Asn Cys Gly His His  Glu Asp Ala Gly Val  Ile Cys Ser 
    1715                 1720                 1725             


Ala Ala  Gln Ser Gln Ser Thr  Pro Arg Pro Asp Thr  Trp Leu Thr 
    1730                 1735                 1740             


Thr Asn  Leu Pro Ala Leu Thr  Val Gly Ser Glu Ser  Ser Leu Ala 
    1745                 1750                 1755             


Leu Arg  Leu Val Asn Gly Gly  Asp Arg Cys Arg Gly  Arg Val Glu 
    1760                 1765                 1770             


Val Leu  Tyr Arg Gly Ser Trp  Gly Thr Val Cys Asp  Asp Ser Trp 
    1775                 1780                 1785             


Asp Thr  Asn Asp Ala Asn Val  Val Cys Arg Gln Leu  Gly Cys Gly 
    1790                 1795                 1800             


Trp Ala  Met Ser Ala Pro Gly  Asn Ala Arg Phe Gly  Gln Gly Ser 
    1805                 1810                 1815             


Gly Pro  Ile Val Leu Asp Asp  Val Arg Cys Ser Gly  Asn Glu Ser 
    1820                 1825                 1830             


Tyr Leu  Trp Ser Cys Pro His  Lys Gly Trp Leu Thr  His Asn Cys 
    1835                 1840                 1845             


Gly His  His Glu Asp Ala Gly  Val Ile Cys Ser Ala  Thr Gln Ile 
    1850                 1855                 1860             


Asn Ser  Thr Thr Thr Asp Trp  Trp His Pro Thr Thr  Thr Thr Thr 
    1865                 1870                 1875             


Ala Arg  Pro Ser Ser Asn Cys  Gly Gly Phe Leu Phe  Tyr Ala Ser 
    1880                 1885                 1890             


Gly Thr  Phe Ser Ser Pro Ser  Tyr Pro Ala Tyr Tyr  Pro Asn Asn 
    1895                 1900                 1905             


Ala Lys  Cys Val Trp Glu Ile  Glu Val Asn Ser Gly  Tyr Arg Ile 
    1910                 1915                 1920             


Asn Leu  Gly Phe Ser Asn Leu  Lys Leu Glu Ala His  His Asn Cys 
    1925                 1930                 1935             


Ser Phe  Asp Tyr Val Glu Ile  Phe Asp Gly Ser Leu  Asn Ser Ser 
    1940                 1945                 1950             


Leu Leu  Leu Gly Lys Ile Cys  Asn Asp Thr Arg Gln  Ile Phe Thr 
    1955                 1960                 1965             


Ser Ser  Tyr Asn Arg Met Thr  Ile His Phe Arg Ser  Asp Ile Ser 
    1970                 1975                 1980             


Phe Gln  Asn Thr Gly Phe Leu  Ala Trp Tyr Asn Ser  Phe Pro Ser 
    1985                 1990                 1995             


Asp Ala  Thr Leu Arg Leu Val  Asn Leu Asn Ser Ser  Tyr Gly Leu 
    2000                 2005                 2010             


Cys Ala  Gly Arg Val Glu Ile  Tyr His Gly Gly Thr  Trp Gly Thr 
    2015                 2020                 2025             


Val Cys  Asp Asp Ser Trp Thr  Ile Gln Glu Ala Glu  Val Val Cys 
    2030                 2035                 2040             


Arg Gln  Leu Gly Cys Gly Arg  Ala Val Ser Ala Leu  Gly Asn Ala 
    2045                 2050                 2055             


Tyr Phe  Gly Ser Gly Ser Gly  Pro Ile Thr Leu Asp  Asp Val Glu 
    2060                 2065                 2070             


Cys Ser  Gly Thr Glu Ser Thr  Leu Trp Gln Cys Arg  Asn Arg Gly 
    2075                 2080                 2085             


Trp Phe  Ser His Asn Cys Asn  His Arg Glu Asp Ala  Gly Val Ile 
    2090                 2095                 2100             


Cys Ser  Gly Asn His Leu Ser  Thr Pro Ala Pro Phe  Leu Asn Ile 
    2105                 2110                 2115             


Thr Arg  Pro Asn Thr Asp Tyr  Ser Cys Gly Gly Phe  Leu Ser Gln 
    2120                 2125                 2130             


Pro Ser  Gly Asp Phe Ser Ser  Pro Phe Tyr Pro Gly  Asn Tyr Pro 
    2135                 2140                 2145             


Asn Asn  Ala Lys Cys Val Trp  Asp Ile Glu Val Gln  Asn Asn Tyr 
    2150                 2155                 2160             


Arg Val  Thr Val Ile Phe Arg  Asp Val Gln Leu Glu  Gly Gly Cys 
    2165                 2170                 2175             


Asn Tyr  Asp Tyr Ile Glu Val  Phe Asp Gly Pro Tyr  Arg Ser Ser 
    2180                 2185                 2190             


Pro Leu  Ile Ala Arg Val Cys  Asp Gly Ala Arg Gly  Ser Phe Thr 
    2195                 2200                 2205             


Ser Ser  Ser Asn Phe Met Ser  Ile Arg Phe Ile Ser  Asp His Ser 
    2210                 2215                 2220             


Ile Thr  Arg Arg Gly Phe Arg  Ala Glu Tyr Tyr Ser  Ser Pro Ser 
    2225                 2230                 2235             


Asn Asp  Ser Thr Asn Leu Leu  Cys Leu Pro Asn His  Met Gln Ala 
    2240                 2245                 2250             


Ser Val  Ser Arg Ser Tyr Leu  Gln Ser Leu Gly Phe  Ser Ala Ser 
    2255                 2260                 2265             


Asp Leu  Val Ile Ser Thr Trp  Asn Gly Tyr Tyr Glu  Cys Arg Pro 
    2270                 2275                 2280             


Gln Ile  Thr Pro Asn Leu Val  Ile Phe Thr Ile Pro  Tyr Ser Gly 
    2285                 2290                 2295             


Cys Gly  Thr Phe Lys Gln Ala  Asp Asn Asp Thr Ile  Asp Tyr Ser 
    2300                 2305                 2310             


Asn Phe  Leu Thr Ala Ala Val  Ser Gly Gly Ile Ile  Lys Arg Arg 
    2315                 2320                 2325             


Thr Asp  Leu Arg Ile His Val  Ser Cys Arg Met Leu  Gln Asn Thr 
    2330                 2335                 2340             


Trp Val  Asp Thr Met Tyr Ile  Ala Asn Asp Thr Ile  His Val Ala 
    2345                 2350                 2355             


Asn Asn  Thr Ile Gln Val Glu  Glu Val Gln Tyr Gly  Asn Phe Asp 
    2360                 2365                 2370             


Val Asn  Ile Ser Phe Tyr Thr  Ser Ser Ser Phe Leu  Tyr Pro Val 
    2375                 2380                 2385             


Thr Ser  Arg Pro Tyr Tyr Val  Asp Leu Asn Gln Asp  Leu Tyr Val 
    2390                 2395                 2400             


Gln Ala  Glu Ile Leu His Ser  Asp Ala Val Leu Thr  Leu Phe Val 
    2405                 2410                 2415             


Asp Thr  Cys Val Ala Ser Pro  Tyr Ser Asn Asp Phe  Thr Ser Leu 
    2420                 2425                 2430             


Thr Tyr  Asp Leu Ile Arg Ser  Gly Cys Val Arg Asp  Asp Thr Tyr 
    2435                 2440                 2445             


Gly Pro  Tyr Ser Ser Pro Ser  Leu Arg Ile Ala Arg  Phe Arg Phe 
    2450                 2455                 2460             


Arg Ala  Phe His Phe Leu Asn  Arg Phe Pro Ser Val  Tyr Leu Arg 
    2465                 2470                 2475             


Cys Lys  Met Val Val Cys Arg  Ala Tyr Asp Pro Ser  Ser Arg Cys 
    2480                 2485                 2490             


Tyr Arg  Gly Cys Val Leu Arg  Ser Lys Arg Asp Val  Gly Ser Tyr 
    2495                 2500                 2505             


Gln Glu  Lys Val Asp Val Val  Leu Gly Pro Ile Gln  Leu Gln Thr 
    2510                 2515                 2520             


Pro Pro  Arg Arg Glu Glu Glu  Pro Arg 
    2525                 2530         


<210>  102
<211>  1662
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
    450                 455                 460                 


Ala His Ser Trp Ser Thr Pro Arg Pro Gly Glu Arg Pro Arg Pro Asp 
465                 470                 475                 480 


Thr Leu Pro Thr Ile Thr Leu Pro Ala Ser Thr Val Gly Ser Glu Ser 
                485                 490                 495     


Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly Arg 
            500                 505                 510         


Val Glu Val Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp Asp Ser 
        515                 520                 525             


Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys Gly 
    530                 535                 540                 


Trp Ala Met Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly 
545                 550                 555                 560 


Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr Leu 
                565                 570                 575     


Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His Ser 
            580                 585                 590         


Glu Asp Ala Gly Val Ile Cys Ser Ala Ser Gln Ser Arg Pro Thr Pro 
        595                 600                 605             


Ser Pro Asp Thr Trp Pro Thr Ser His Ala Ser Thr Ala Gly Ser Glu 
    610                 615                 620                 


Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Gln Gly 
625                 630                 635                 640 


Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp Asp 
                645                 650                 655     


Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly Cys 
            660                 665                 670         


Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser 
        675                 680                 685             


Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser Tyr 
    690                 695                 700                 


Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly His 
705                 710                 715                 720 


His Glu Asp Ala Gly Val Ile Cys Ser Ala Ser Gln Ser Gln Pro Thr 
                725                 730                 735     


Pro Ser Pro Asp Thr Trp Pro Thr Ser Arg Ala Ser Thr Ala Gly Ser 
            740                 745                 750         


Glu Ser Thr Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys Arg 
        755                 760                 765             


Gly Arg Val Glu Val Leu Tyr Gln Gly Ser Trp Gly Thr Val Cys Asp 
    770                 775                 780                 


Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
785                 790                 795                 800 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln Phe Gly Gln Gly 
                805                 810                 815     


Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
            820                 825                 830         


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
        835                 840                 845             


His His Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Ser Gln Ser 
    850                 855                 860                 


Thr Pro Arg Pro Asp Thr Trp Leu Thr Thr Asn Leu Pro Ala Leu Thr 
865                 870                 875                 880 


Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp 
                885                 890                 895     


Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr 
            900                 905                 910         


Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg 
        915                 920                 925             


Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Arg Phe 
    930                 935                 940                 


Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly 
945                 950                 955                 960 


Asn Glu Ser Tyr Leu Trp Ser Cys Pro His Lys Gly Trp Leu Thr His 
                965                 970                 975     


Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Thr Gln 
            980                 985                 990         


Ile Asn Ser Thr Thr Thr Asp Trp  Trp His Pro Thr Thr  Thr Thr Thr 
        995                 1000                 1005             


Ala Arg  Pro Ser Ser Asn Cys  Gly Gly Phe Leu Phe  Tyr Ala Ser 
    1010                 1015                 1020             


Gly Thr  Phe Ser Ser Pro Ser  Tyr Pro Ala Tyr Tyr  Pro Asn Asn 
    1025                 1030                 1035             


Ala Lys  Cys Val Trp Glu Ile  Glu Val Asn Ser Gly  Tyr Arg Ile 
    1040                 1045                 1050             


Asn Leu  Gly Phe Ser Asn Leu  Lys Leu Glu Ala His  His Asn Cys 
    1055                 1060                 1065             


Ser Phe  Asp Tyr Val Glu Ile  Phe Asp Gly Ser Leu  Asn Ser Ser 
    1070                 1075                 1080             


Leu Leu  Leu Gly Lys Ile Cys  Asn Asp Thr Arg Gln  Ile Phe Thr 
    1085                 1090                 1095             


Ser Ser  Tyr Asn Arg Met Thr  Ile His Phe Arg Ser  Asp Ile Ser 
    1100                 1105                 1110             


Phe Gln  Asn Thr Gly Phe Leu  Ala Trp Tyr Asn Ser  Phe Pro Ser 
    1115                 1120                 1125             


Asp Ala  Thr Leu Arg Leu Val  Asn Leu Asn Ser Ser  Tyr Gly Leu 
    1130                 1135                 1140             


Cys Ala  Gly Arg Val Glu Ile  Tyr His Gly Gly Thr  Trp Gly Thr 
    1145                 1150                 1155             


Val Cys  Asp Asp Ser Trp Thr  Ile Gln Glu Ala Glu  Val Val Cys 
    1160                 1165                 1170             


Arg Gln  Leu Gly Cys Gly Arg  Ala Val Ser Ala Leu  Gly Asn Ala 
    1175                 1180                 1185             


Tyr Phe  Gly Ser Gly Ser Gly  Pro Ile Thr Leu Asp  Asp Val Glu 
    1190                 1195                 1200             


Cys Ser  Gly Thr Glu Ser Thr  Leu Trp Gln Cys Arg  Asn Arg Gly 
    1205                 1210                 1215             


Trp Phe  Ser His Asn Cys Asn  His Arg Glu Asp Ala  Gly Val Ile 
    1220                 1225                 1230             


Cys Ser  Gly Asn His Leu Ser  Thr Pro Ala Pro Phe  Leu Asn Ile 
    1235                 1240                 1245             


Thr Arg  Pro Asn Thr Asp Tyr  Ser Cys Gly Gly Phe  Leu Ser Gln 
    1250                 1255                 1260             


Pro Ser  Gly Asp Phe Ser Ser  Pro Phe Tyr Pro Gly  Asn Tyr Pro 
    1265                 1270                 1275             


Asn Asn  Ala Lys Cys Val Trp  Asp Ile Glu Val Gln  Asn Asn Tyr 
    1280                 1285                 1290             


Arg Val  Thr Val Ile Phe Arg  Asp Val Gln Leu Glu  Gly Gly Cys 
    1295                 1300                 1305             


Asn Tyr  Asp Tyr Ile Glu Val  Phe Asp Gly Pro Tyr  Arg Ser Ser 
    1310                 1315                 1320             


Pro Leu  Ile Ala Arg Val Cys  Asp Gly Ala Arg Gly  Ser Phe Thr 
    1325                 1330                 1335             


Ser Ser  Ser Asn Phe Met Ser  Ile Arg Phe Ile Ser  Asp His Ser 
    1340                 1345                 1350             


Ile Thr  Arg Arg Gly Phe Arg  Ala Glu Tyr Tyr Ser  Ser Pro Ser 
    1355                 1360                 1365             


Asn Asp  Ser Thr Asn Leu Leu  Cys Leu Pro Asn His  Met Gln Ala 
    1370                 1375                 1380             


Ser Val  Ser Arg Ser Tyr Leu  Gln Ser Leu Gly Phe  Ser Ala Ser 
    1385                 1390                 1395             


Asp Leu  Val Ile Ser Thr Trp  Asn Gly Tyr Tyr Glu  Cys Arg Pro 
    1400                 1405                 1410             


Gln Ile  Thr Pro Asn Leu Val  Ile Phe Thr Ile Pro  Tyr Ser Gly 
    1415                 1420                 1425             


Cys Gly  Thr Phe Lys Gln Ala  Asp Asn Asp Thr Ile  Asp Tyr Ser 
    1430                 1435                 1440             


Asn Phe  Leu Thr Ala Ala Val  Ser Gly Gly Ile Ile  Lys Arg Arg 
    1445                 1450                 1455             


Thr Asp  Leu Arg Ile His Val  Ser Cys Arg Met Leu  Gln Asn Thr 
    1460                 1465                 1470             


Trp Val  Asp Thr Met Tyr Ile  Ala Asn Asp Thr Ile  His Val Ala 
    1475                 1480                 1485             


Asn Asn  Thr Ile Gln Val Glu  Glu Val Gln Tyr Gly  Asn Phe Asp 
    1490                 1495                 1500             


Val Asn  Ile Ser Phe Tyr Thr  Ser Ser Ser Phe Leu  Tyr Pro Val 
    1505                 1510                 1515             


Thr Ser  Arg Pro Tyr Tyr Val  Asp Leu Asn Gln Asp  Leu Tyr Val 
    1520                 1525                 1530             


Gln Ala  Glu Ile Leu His Ser  Asp Ala Val Leu Thr  Leu Phe Val 
    1535                 1540                 1545             


Asp Thr  Cys Val Ala Ser Pro  Tyr Ser Asn Asp Phe  Thr Ser Leu 
    1550                 1555                 1560             


Thr Tyr  Asp Leu Ile Arg Ser  Gly Cys Val Arg Asp  Asp Thr Tyr 
    1565                 1570                 1575             


Gly Pro  Tyr Ser Ser Pro Ser  Leu Arg Ile Ala Arg  Phe Arg Phe 
    1580                 1585                 1590             


Arg Ala  Phe His Phe Leu Asn  Arg Phe Pro Ser Val  Tyr Leu Arg 
    1595                 1600                 1605             


Cys Lys  Met Val Val Cys Arg  Ala Tyr Asp Pro Ser  Ser Arg Cys 
    1610                 1615                 1620             


Tyr Arg  Gly Cys Val Leu Arg  Ser Lys Arg Asp Val  Gly Ser Tyr 
    1625                 1630                 1635             


Gln Glu  Lys Val Asp Val Val  Leu Gly Pro Ile Gln  Leu Gln Thr 
    1640                 1645                 1650             


Pro Pro  Arg Arg Glu Glu Glu  Pro Arg 
    1655                 1660         


<210>  103
<211>  2393
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
    450                 455                 460                 


Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro Thr Ile Thr 
465                 470                 475                 480 


Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu 
                485                 490                 495     


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
            500                 505                 510         


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala 
        515                 520                 525             


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Leu Ala Pro 
    530                 535                 540                 


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
545                 550                 555                 560 


Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
                565                 570                 575     


Gly Trp Leu Ser His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile 
            580                 585                 590         


Cys Ser Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
        595                 600                 605             


Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
    610                 615                 620                 


Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
625                 630                 635                 640 


Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg 
                645                 650                 655     


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
            660                 665                 670         


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro Asn Asn Gly Trp Leu Ser 
        675                 680                 685             


His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Ala 
    690                 695                 700                 


Gln Ser Arg Ser Thr Pro Arg Pro Asp Thr Leu Ser Thr Ile Thr Leu 
705                 710                 715                 720 


Pro Pro Ser Thr Val Gly Ser Glu Ser Ser Leu Thr Leu Arg Leu Val 
                725                 730                 735     


Asn Gly Ser Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly 
            740                 745                 750         


Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn 
        755                 760                 765             


Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly 
    770                 775                 780                 


Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val 
785                 790                 795                 800 


Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly 
                805                 810                 815     


Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys 
            820                 825                 830         


Ser Val Ser Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr 
        835                 840                 845             


Ser His Ala Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu 
    850                 855                 860                 


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
865                 870                 875                 880 


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala 
                885                 890                 895     


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro 
            900                 905                 910         


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
        915                 920                 925             


Val Arg Cys Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
    930                 935                 940                 


Gly Trp Leu Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile 
945                 950                 955                 960 


Cys Ser Ala Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro 
                965                 970                 975     


Thr Ile Thr Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala 
            980                 985                 990         


Leu Arg Leu Val Asn Gly Gly Asp  Arg Cys Gln Gly Arg  Val Glu Val 
        995                 1000                 1005             


Leu Tyr  Gln Gly Ser Trp Gly  Thr Val Cys Asp Asp  Ser Trp Asp 
    1010                 1015                 1020             


Thr Asn  Asp Ala Asn Val Val  Cys Arg Gln Leu Gly  Cys Gly Trp 
    1025                 1030                 1035             


Ala Met  Ser Ala Pro Gly Asn  Ala Arg Phe Gly Gln  Gly Ser Gly 
    1040                 1045                 1050             


Pro Ile  Val Leu Asp Asp Val  Arg Cys Ser Gly His  Glu Ser Tyr 
    1055                 1060                 1065             


Leu Trp  Ser Cys Pro His Asn  Gly Trp Leu Ser His  Asn Cys Gly 
    1070                 1075                 1080             


His Ser  Glu Asp Ala Gly Val  Ile Cys Ser Ala Ser  Gln Ser Arg 
    1085                 1090                 1095             


Pro Thr  Pro Ser Pro Asp Thr  Trp Pro Thr Ser His  Ala Ser Thr 
    1100                 1105                 1110             


Ala Gly  Ser Glu Ser Ser Leu  Ala Leu Arg Leu Val  Asn Gly Gly 
    1115                 1120                 1125             


Asp Arg  Cys Gln Gly Arg Val  Glu Val Leu Tyr Arg  Gly Ser Trp 
    1130                 1135                 1140             


Gly Thr  Val Cys Asp Asp Tyr  Trp Asp Thr Asn Asp  Ala Asn Val 
    1145                 1150                 1155             


Val Cys  Arg Gln Leu Gly Cys  Gly Trp Ala Met Ser  Ala Pro Gly 
    1160                 1165                 1170             


Asn Ala  Arg Phe Gly Gln Gly  Ser Gly Pro Ile Val  Leu Asp Asp 
    1175                 1180                 1185             


Val Arg  Cys Ser Gly His Glu  Ser Tyr Leu Trp Ser  Cys Pro His 
    1190                 1195                 1200             


Asn Gly  Trp Leu Ser His Asn  Cys Gly His His Glu  Asp Ala Gly 
    1205                 1210                 1215             


Val Ile  Cys Ser Ala Ser Gln  Ser Gln Pro Thr Pro  Ser Pro Asp 
    1220                 1225                 1230             


Thr Trp  Pro Thr Ser His Ala  Ser Thr Ala Gly Ser  Glu Ser Ser 
    1235                 1240                 1245             


Leu Ala  Leu Arg Leu Val Asn  Gly Gly Asp Arg Cys  Gln Gly Arg 
    1250                 1255                 1260             


Val Glu  Val Leu Tyr Arg Gly  Ser Trp Gly Thr Val  Cys Asp Asp 
    1265                 1270                 1275             


Tyr Trp  Asp Thr Asn Asp Ala  Asn Val Val Cys Arg  Gln Leu Gly 
    1280                 1285                 1290             


Cys Gly  Trp Ala Thr Ser Ala  Pro Gly Asn Ala Arg  Phe Gly Gln 
    1295                 1300                 1305             


Gly Ser  Gly Pro Ile Val Leu  Asp Asp Val Arg Cys  Ser Gly His 
    1310                 1315                 1320             


Glu Ser  Tyr Leu Trp Ser Cys  Pro His Asn Gly Trp  Leu Ser His 
    1325                 1330                 1335             


Asn Cys  Gly His His Glu Asp  Ala Gly Val Ile Cys  Ser Ala Ser 
    1340                 1345                 1350             


Gln Ser  Gln Pro Thr Pro Ser  Pro Asp Thr Trp Pro  Thr Ser His 
    1355                 1360                 1365             


Ala Ser  Thr Ala Gly Ser Glu  Ser Ser Leu Ala Leu  Arg Leu Val 
    1370                 1375                 1380             


Asn Gly  Gly Asp Arg Cys Gln  Gly Arg Val Glu Val  Leu Tyr Arg 
    1385                 1390                 1395             


Gly Ser  Trp Gly Thr Val Cys  Asp Asp Tyr Trp Asp  Thr Asn Asp 
    1400                 1405                 1410             


Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys Gly Trp  Ala Thr Ser 
    1415                 1420                 1425             


Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly Ser Gly  Pro Ile Val 
    1430                 1435                 1440             


Leu Asp  Asp Val Arg Cys Ser  Gly His Glu Ser Tyr  Leu Trp Ser 
    1445                 1450                 1455             


Cys Pro  His Asn Gly Trp Leu  Ser His Asn Cys Gly  His His Glu 
    1460                 1465                 1470             


Asp Ala  Gly Val Ile Cys Ser  Ala Ser Gln Ser Gln  Pro Thr Pro 
    1475                 1480                 1485             


Ser Pro  Asp Thr Trp Pro Thr  Ser Arg Ala Ser Thr  Ala Gly Ser 
    1490                 1495                 1500             


Glu Ser  Thr Leu Ala Leu Arg  Leu Val Asn Gly Gly  Asp Arg Cys 
    1505                 1510                 1515             


Arg Gly  Arg Val Glu Val Leu  Tyr Gln Gly Ser Trp  Gly Thr Val 
    1520                 1525                 1530             


Cys Asp  Asp Tyr Trp Asp Thr  Asn Asp Ala Asn Val  Val Cys Arg 
    1535                 1540                 1545             


Gln Leu  Gly Cys Gly Trp Ala  Met Ser Ala Pro Gly  Asn Ala Gln 
    1550                 1555                 1560             


Phe Gly  Gln Gly Ser Gly Pro  Ile Val Leu Asp Asp  Val Arg Cys 
    1565                 1570                 1575             


Ser Gly  His Glu Ser Tyr Leu  Trp Ser Cys Pro His  Asn Gly Trp 
    1580                 1585                 1590             


Leu Ser  His Asn Cys Gly His  His Glu Asp Ala Gly  Val Ile Cys 
    1595                 1600                 1605             


Ser Ala  Ala Gln Ser Gln Ser  Thr Pro Arg Pro Asp  Thr Trp Leu 
    1610                 1615                 1620             


Thr Thr  Asn Leu Pro Ala Leu  Thr Val Gly Ser Glu  Ser Ser Leu 
    1625                 1630                 1635             


Ala Leu  Arg Leu Val Asn Gly  Gly Asp Arg Cys Arg  Gly Arg Val 
    1640                 1645                 1650             


Glu Val  Leu Tyr Arg Gly Ser  Trp Gly Thr Val Cys  Asp Asp Ser 
    1655                 1660                 1665             


Trp Asp  Thr Asn Asp Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys 
    1670                 1675                 1680             


Gly Trp  Ala Met Ser Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly 
    1685                 1690                 1695             


Ser Gly  Pro Ile Val Leu Asp  Asp Val Arg Cys Ser  Gly Asn Glu 
    1700                 1705                 1710             


Ser Tyr  Leu Trp Ser Cys Pro  His Lys Gly Trp Leu  Thr His Asn 
    1715                 1720                 1725             


Cys Gly  His His Glu Asp Ala  Gly Val Ile Cys Ser  Gly Pro Ser 
    1730                 1735                 1740             


Ser Asn  Cys Gly Gly Phe Leu  Phe Tyr Ala Ser Gly  Thr Phe Ser 
    1745                 1750                 1755             


Ser Pro  Ser Tyr Pro Ala Tyr  Tyr Pro Asn Asn Ala  Lys Cys Val 
    1760                 1765                 1770             


Trp Glu  Ile Glu Val Asn Ser  Gly Tyr Arg Ile Asn  Leu Gly Phe 
    1775                 1780                 1785             


Ser Asn  Leu Lys Leu Glu Ala  His His Asn Cys Ser  Phe Asp Tyr 
    1790                 1795                 1800             


Val Glu  Ile Phe Asp Gly Ser  Leu Asn Ser Ser Leu  Leu Leu Gly 
    1805                 1810                 1815             


Lys Ile  Cys Asn Asp Thr Arg  Gln Ile Phe Thr Ser  Ser Tyr Asn 
    1820                 1825                 1830             


Arg Met  Thr Ile His Phe Arg  Ser Asp Ile Ser Phe  Gln Asn Thr 
    1835                 1840                 1845             


Gly Phe  Leu Ala Trp Tyr Asn  Ser Phe Pro Ser Asp  Ala Thr Leu 
    1850                 1855                 1860             


Arg Leu  Val Asn Leu Asn Ser  Ser Tyr Gly Leu Cys  Ala Gly Arg 
    1865                 1870                 1875             


Val Glu  Ile Tyr His Gly Gly  Thr Trp Gly Thr Val  Cys Asp Asp 
    1880                 1885                 1890             


Ser Trp  Thr Ile Gln Glu Ala  Glu Val Val Cys Arg  Gln Leu Gly 
    1895                 1900                 1905             


Cys Gly  Arg Ala Val Ser Ala  Leu Gly Asn Ala Tyr  Phe Gly Ser 
    1910                 1915                 1920             


Gly Ser  Gly Pro Ile Thr Leu  Asp Asp Val Glu Cys  Ser Gly Thr 
    1925                 1930                 1935             


Glu Ser  Thr Leu Trp Gln Cys  Arg Asn Arg Gly Trp  Phe Ser His 
    1940                 1945                 1950             


Asn Cys  Asn His Arg Glu Asp  Ala Gly Val Ile Cys  Ser Gly Asn 
    1955                 1960                 1965             


His Leu  Ser Thr Pro Ala Pro  Phe Leu Asn Ile Thr  Arg Pro Asn 
    1970                 1975                 1980             


Thr Asp  Tyr Ser Cys Gly Gly  Phe Leu Ser Gln Pro  Ser Gly Asp 
    1985                 1990                 1995             


Phe Ser  Ser Pro Phe Tyr Pro  Gly Asn Tyr Pro Asn  Asn Ala Lys 
    2000                 2005                 2010             


Cys Val  Trp Asp Ile Glu Val  Gln Asn Asn Tyr Arg  Val Thr Val 
    2015                 2020                 2025             


Ile Phe  Arg Asp Val Gln Leu  Glu Gly Gly Cys Asn  Tyr Asp Tyr 
    2030                 2035                 2040             


Ile Glu  Val Phe Asp Gly Pro  Tyr Arg Ser Ser Pro  Leu Ile Ala 
    2045                 2050                 2055             


Arg Val  Cys Asp Gly Ala Arg  Gly Ser Phe Thr Ser  Ser Ser Asn 
    2060                 2065                 2070             


Phe Met  Ser Ile Arg Phe Ile  Ser Asp His Ser Ile  Thr Arg Arg 
    2075                 2080                 2085             


Gly Phe  Arg Ala Glu Tyr Tyr  Ser Ser Pro Ser Asn  Asp Ser Thr 
    2090                 2095                 2100             


Asn Leu  Leu Cys Leu Pro Asn  His Met Gln Ala Ser  Val Ser Arg 
    2105                 2110                 2115             


Ser Tyr  Leu Gln Ser Leu Gly  Phe Ser Ala Ser Asp  Leu Val Ile 
    2120                 2125                 2130             


Ser Thr  Trp Asn Gly Tyr Tyr  Glu Cys Arg Pro Gln  Ile Thr Pro 
    2135                 2140                 2145             


Asn Leu  Val Ile Phe Thr Ile  Pro Tyr Ser Gly Cys  Gly Thr Phe 
    2150                 2155                 2160             


Lys Gln  Ala Asp Asn Asp Thr  Ile Asp Tyr Ser Asn  Phe Leu Thr 
    2165                 2170                 2175             


Ala Ala  Val Ser Gly Gly Ile  Ile Lys Arg Arg Thr  Asp Leu Arg 
    2180                 2185                 2190             


Ile His  Val Ser Cys Arg Met  Leu Gln Asn Thr Trp  Val Asp Thr 
    2195                 2200                 2205             


Met Tyr  Ile Ala Asn Asp Thr  Ile His Val Ala Asn  Asn Thr Ile 
    2210                 2215                 2220             


Gln Val  Glu Glu Val Gln Tyr  Gly Asn Phe Asp Val  Asn Ile Ser 
    2225                 2230                 2235             


Phe Tyr  Thr Ser Ser Ser Phe  Leu Tyr Pro Val Thr  Ser Arg Pro 
    2240                 2245                 2250             


Tyr Tyr  Val Asp Leu Asn Gln  Asp Leu Tyr Val Gln  Ala Glu Ile 
    2255                 2260                 2265             


Leu His  Ser Asp Ala Val Leu  Thr Leu Phe Val Asp  Thr Cys Val 
    2270                 2275                 2280             


Ala Ser  Pro Tyr Ser Asn Asp  Phe Thr Ser Leu Thr  Tyr Asp Leu 
    2285                 2290                 2295             


Ile Arg  Ser Gly Cys Val Arg  Asp Asp Thr Tyr Gly  Pro Tyr Ser 
    2300                 2305                 2310             


Ser Pro  Ser Leu Arg Ile Ala  Arg Phe Arg Phe Arg  Ala Phe His 
    2315                 2320                 2325             


Phe Leu  Asn Arg Phe Pro Ser  Val Tyr Leu Arg Cys  Lys Met Val 
    2330                 2335                 2340             


Val Cys  Arg Ala Tyr Asp Pro  Ser Ser Arg Cys Tyr  Arg Gly Cys 
    2345                 2350                 2355             


Val Leu  Arg Ser Lys Arg Asp  Val Gly Ser Tyr Gln  Glu Lys Val 
    2360                 2365                 2370             


Asp Val  Val Leu Gly Pro Ile  Gln Leu Gln Thr Pro  Pro Arg Arg 
    2375                 2380                 2385             


Glu Glu  Glu Pro Arg 
    2390             


<210>  104
<211>  1133
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Pro Gln Ser Arg Pro 
        195                 200                 205             


Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala Ser Thr Ala Gly 
    210                 215                 220                 


Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg Cys 
225                 230                 235                 240 


Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys 
                245                 250                 255     


Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu 
            260                 265                 270         


Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg Phe Gly Gln 
        275                 280                 285             


Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly His Glu 
    290                 295                 300                 


Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys 
305                 310                 315                 320 


Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Ser Gln Ser Gln 
                325                 330                 335     


Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser Arg Ala Ser Thr Ala 
            340                 345                 350         


Gly Ser Glu Ser Thr Leu Ala Leu Arg Leu Val Asn Gly Gly Asp Arg 
        355                 360                 365             


Cys Arg Gly Arg Val Glu Val Leu Tyr Gln Gly Ser Trp Gly Thr Val 
    370                 375                 380                 


Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln 
385                 390                 395                 400 


Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln Phe Gly 
                405                 410                 415     


Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser Gly His 
            420                 425                 430         


Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn 
        435                 440                 445             


Cys Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Thr Gln Ile 
    450                 455                 460                 


Asn Ser Thr Thr Thr Asp Trp Trp His Pro Thr Thr Thr Thr Thr Ala 
465                 470                 475                 480 


Arg Pro Ser Ser Asn Cys Gly Gly Phe Leu Phe Tyr Ala Ser Gly Thr 
                485                 490                 495     


Phe Ser Ser Pro Ser Tyr Pro Ala Tyr Tyr Pro Asn Asn Ala Lys Cys 
            500                 505                 510         


Val Trp Glu Ile Glu Val Asn Ser Gly Tyr Arg Ile Asn Leu Gly Phe 
        515                 520                 525             


Ser Asn Leu Lys Leu Glu Ala His His Asn Cys Ser Phe Asp Tyr Val 
    530                 535                 540                 


Glu Ile Phe Asp Gly Ser Leu Asn Ser Ser Leu Leu Leu Gly Lys Ile 
545                 550                 555                 560 


Cys Asn Asp Thr Arg Gln Ile Phe Thr Ser Ser Tyr Asn Arg Met Thr 
                565                 570                 575     


Ile His Phe Arg Ser Asp Ile Ser Phe Gln Asn Thr Gly Phe Leu Ala 
            580                 585                 590         


Trp Tyr Asn Ser Phe Pro Ser Asp Ala Thr Leu Arg Leu Val Asn Leu 
        595                 600                 605             


Asn Ser Ser Tyr Gly Leu Cys Ala Gly Arg Val Glu Ile Tyr His Gly 
    610                 615                 620                 


Gly Thr Trp Gly Thr Val Cys Asp Asp Ser Trp Thr Ile Gln Glu Ala 
625                 630                 635                 640 


Glu Val Val Cys Arg Gln Leu Gly Cys Gly Arg Ala Val Ser Ala Leu 
                645                 650                 655     


Gly Asn Ala Tyr Phe Gly Ser Gly Ser Gly Pro Ile Thr Leu Asp Asp 
            660                 665                 670         


Val Glu Cys Ser Gly Thr Glu Ser Thr Leu Trp Gln Cys Arg Asn Arg 
        675                 680                 685             


Gly Trp Phe Ser His Asn Cys Asn His Arg Glu Asp Ala Gly Val Ile 
    690                 695                 700                 


Cys Ser Gly Asn His Leu Ser Thr Pro Ala Pro Phe Leu Asn Ile Thr 
705                 710                 715                 720 


Arg Pro Asn Thr Asp Tyr Ser Cys Gly Gly Phe Leu Ser Gln Pro Ser 
                725                 730                 735     


Gly Asp Phe Ser Ser Pro Phe Tyr Pro Gly Asn Tyr Pro Asn Asn Ala 
            740                 745                 750         


Lys Cys Val Trp Asp Ile Glu Val Gln Asn Asn Tyr Arg Val Thr Val 
        755                 760                 765             


Ile Phe Arg Asp Val Gln Leu Glu Gly Gly Cys Asn Tyr Asp Tyr Ile 
    770                 775                 780                 


Glu Val Phe Asp Gly Pro Tyr Arg Ser Ser Pro Leu Ile Ala Arg Val 
785                 790                 795                 800 


Cys Asp Gly Ala Arg Gly Ser Phe Thr Ser Ser Ser Asn Phe Met Ser 
                805                 810                 815     


Ile Arg Phe Ile Ser Asp His Ser Ile Thr Arg Arg Gly Phe Arg Ala 
            820                 825                 830         


Glu Tyr Tyr Ser Ser Pro Ser Asn Asp Ser Thr Asn Leu Leu Cys Leu 
        835                 840                 845             


Pro Asn His Met Gln Ala Ser Val Ser Arg Ser Tyr Leu Gln Ser Leu 
    850                 855                 860                 


Gly Phe Ser Ala Ser Asp Leu Val Ile Ser Thr Trp Asn Gly Tyr Tyr 
865                 870                 875                 880 


Glu Cys Arg Pro Gln Ile Thr Pro Asn Leu Val Ile Phe Thr Ile Pro 
                885                 890                 895     


Tyr Ser Gly Cys Gly Thr Phe Lys Gln Ala Asp Asn Asp Thr Ile Asp 
            900                 905                 910         


Tyr Ser Asn Phe Leu Thr Ala Ala Val Ser Gly Gly Ile Ile Lys Arg 
        915                 920                 925             


Arg Thr Asp Leu Arg Ile His Val Ser Cys Arg Met Leu Gln Asn Thr 
    930                 935                 940                 


Trp Val Asp Thr Met Tyr Ile Ala Asn Asp Thr Ile His Val Ala Asn 
945                 950                 955                 960 


Asn Thr Ile Gln Val Glu Glu Val Gln Tyr Gly Asn Phe Asp Val Asn 
                965                 970                 975     


Ile Ser Phe Tyr Thr Ser Ser Ser Phe Leu Tyr Pro Val Thr Ser Arg 
            980                 985                 990         


Pro Tyr Tyr Val Asp Leu Asn Gln  Asp Leu Tyr Val Gln  Ala Glu Ile 
        995                 1000                 1005             


Leu His  Ser Asp Ala Val Leu  Thr Leu Phe Val Asp  Thr Cys Val 
    1010                 1015                 1020             


Ala Ser  Pro Tyr Ser Asn Asp  Phe Thr Ser Leu Thr  Tyr Asp Leu 
    1025                 1030                 1035             


Ile Arg  Ser Gly Cys Val Arg  Asp Asp Thr Tyr Gly  Pro Tyr Ser 
    1040                 1045                 1050             


Ser Pro  Ser Leu Arg Ile Ala  Arg Phe Arg Phe Arg  Ala Phe His 
    1055                 1060                 1065             


Phe Leu  Asn Arg Phe Pro Ser  Val Tyr Leu Arg Cys  Lys Met Val 
    1070                 1075                 1080             


Val Cys  Arg Ala Tyr Asp Pro  Ser Ser Arg Cys Tyr  Arg Gly Cys 
    1085                 1090                 1095             


Val Leu  Arg Ser Lys Arg Asp  Val Gly Ser Tyr Gln  Glu Lys Val 
    1100                 1105                 1110             


Asp Val  Val Leu Gly Pro Ile  Gln Leu Gln Thr Pro  Pro Arg Arg 
    1115                 1120                 1125             


Glu Glu  Glu Pro Arg 
    1130             


<210>  105
<211>  5405
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Gly Ala Leu Trp Ser Trp Trp Ile Leu Trp Ala Gly Ala Thr Leu 
1               5                   10                  15      


Leu Trp Gly Leu Thr Gln Glu Ala Ser Val Asp Leu Lys Asn Thr Gly 
            20                  25                  30          


Arg Glu Glu Phe Leu Thr Ala Phe Leu Gln Asn Tyr Gln Leu Ala Tyr 
        35                  40                  45              


Ser Lys Ala Tyr Pro Arg Leu Leu Ile Ser Ser Leu Ser Glu Ser Pro 
    50                  55                  60                  


Ala Ser Val Ser Ile Leu Ser Gln Ala Asp Asn Thr Ser Lys Lys Val 
65                  70                  75                  80  


Thr Val Arg Pro Gly Glu Ser Val Met Val Asn Ile Ser Ala Lys Ala 
                85                  90                  95      


Glu Met Ile Gly Ser Lys Ile Phe Gln His Ala Val Val Ile His Ser 
            100                 105                 110         


Asp Tyr Ala Ile Ser Val Gln Ala Leu Asn Ala Lys Pro Asp Thr Ala 
        115                 120                 125             


Glu Leu Thr Leu Leu Arg Pro Ile Gln Ala Leu Gly Thr Glu Tyr Phe 
    130                 135                 140                 


Val Leu Thr Pro Pro Gly Thr Ser Ala Arg Asn Val Lys Glu Phe Ala 
145                 150                 155                 160 


Val Val Ala Gly Ala Ala Gly Ala Ser Val Ser Val Thr Leu Lys Gly 
                165                 170                 175     


Ser Val Thr Phe Asn Gly Lys Phe Tyr Pro Ala Gly Asp Val Leu Arg 
            180                 185                 190         


Val Thr Leu Gln Pro Tyr Asn Val Ala Gln Leu Gln Ser Ser Val Asp 
        195                 200                 205             


Leu Ser Gly Ser Lys Val Thr Ala Ser Ser Pro Val Ala Val Leu Ser 
    210                 215                 220                 


Gly His Ser Cys Ala Gln Lys His Thr Thr Cys Asn His Val Val Glu 
225                 230                 235                 240 


Gln Leu Leu Pro Thr Ser Ala Trp Gly Thr His Tyr Val Val Pro Thr 
                245                 250                 255     


Leu Ala Ser Gln Ser Arg Tyr Asp Leu Ala Phe Val Val Ala Ser Gln 
            260                 265                 270         


Ala Thr Lys Leu Thr Tyr Asn His Gly Gly Ile Thr Gly Ser Arg Gly 
        275                 280                 285             


Leu Gln Ala Gly Asp Val Val Glu Phe Glu Val Arg Pro Ser Trp Pro 
    290                 295                 300                 


Leu Tyr Leu Ser Ala Asn Val Gly Ile Gln Val Leu Leu Phe Gly Thr 
305                 310                 315                 320 


Gly Ala Ile Arg Asn Glu Val Thr Tyr Asp Pro Tyr Leu Val Leu Ile 
                325                 330                 335     


Pro Asp Val Ala Ala Tyr Cys Pro Ala Tyr Val Val Lys Ser Val Pro 
            340                 345                 350         


Gly Cys Glu Gly Val Ala Leu Val Val Ala Gln Thr Lys Ala Ile Ser 
        355                 360                 365             


Gly Leu Thr Ile Asp Gly His Ala Val Gly Ala Lys Leu Thr Trp Glu 
    370                 375                 380                 


Ala Val Pro Gly Ser Glu Phe Ser Tyr Ala Glu Val Glu Leu Gly Thr 
385                 390                 395                 400 


Ala Asp Met Ile His Thr Ala Glu Ala Thr Thr Asn Leu Gly Leu Leu 
                405                 410                 415     


Thr Phe Gly Leu Ala Lys Ala Ile Gly Tyr Ala Thr Ala Ala Asp Cys 
            420                 425                 430         


Gly Arg Thr Val Leu Ser Pro Val Glu Pro Ser Cys Glu Gly Met Gln 
        435                 440                 445             


Cys Ala Ala Gly Gln Arg Cys Gln Val Val Gly Gly Lys Ala Gly Cys 
    450                 455                 460                 


Val Ala Glu Ser Thr Ala Val Cys Arg Ala Gln Gly Asp Pro His Tyr 
465                 470                 475                 480 


Thr Thr Phe Asp Gly Arg Arg Tyr Asp Met Met Gly Thr Cys Ser Tyr 
                485                 490                 495     


Thr Met Val Glu Leu Cys Ser Glu Asp Asp Thr Leu Pro Ala Phe Ser 
            500                 505                 510         


Val Glu Ala Lys Asn Glu His Arg Gly Ser Arg Arg Val Ser Tyr Val 
        515                 520                 525             


Gly Leu Val Thr Val Arg Ala Tyr Ser His Ser Val Ser Leu Thr Arg 
    530                 535                 540                 


Gly Glu Val Gly Phe Val Leu Val Asp Asn Gln Arg Ser Arg Leu Pro 
545                 550                 555                 560 


Val Ser Leu Ser Glu Gly Arg Leu Arg Val Tyr Gln Ser Gly Pro Arg 
                565                 570                 575     


Ala Val Val Glu Leu Val Phe Gly Leu Val Val Thr Tyr Asp Trp Asp 
            580                 585                 590         


Cys Gln Leu Ala Leu Ser Leu Pro Ala Arg Phe Gln Asp Gln Val Cys 
        595                 600                 605             


Gly Leu Cys Gly Asn Tyr Asn Gly Asp Pro Ala Asp Asp Phe Leu Thr 
    610                 615                 620                 


Pro Asp Gly Ala Leu Ala Pro Asp Ala Val Glu Phe Ala Ser Ser Trp 
625                 630                 635                 640 


Lys Leu Asp Asp Gly Asp Tyr Leu Cys Glu Asp Gly Cys Gln Asn Asn 
                645                 650                 655     


Cys Pro Ala Cys Thr Pro Gly Gln Ala Gln His Tyr Glu Gly Asp Arg 
            660                 665                 670         


Leu Cys Gly Met Leu Thr Lys Leu Asp Gly Pro Phe Ala Val Cys His 
        675                 680                 685             


Asp Thr Leu Asp Pro Arg Pro Phe Leu Glu Gln Cys Val Tyr Asp Leu 
    690                 695                 700                 


Cys Val Val Gly Gly Glu Arg Leu Ser Leu Cys Arg Gly Leu Ser Ala 
705                 710                 715                 720 


Tyr Ala Gln Ala Cys Leu Glu Leu Gly Ile Ser Val Gly Asp Trp Arg 
                725                 730                 735     


Ser Pro Ala Asn Cys Pro Leu Ser Cys Pro Ala Asn Ser Arg Tyr Glu 
            740                 745                 750         


Leu Cys Gly Pro Ala Cys Pro Thr Ser Cys Asn Gly Ala Ala Ala Pro 
        755                 760                 765             


Ser Asn Cys Ser Gly Arg Pro Cys Val Glu Gly Cys Val Cys Leu Pro 
    770                 775                 780                 


Gly Phe Val Ala Ser Gly Gly Ala Cys Val Pro Ala Ser Ser Cys Gly 
785                 790                 795                 800 


Cys Thr Phe Gln Gly Leu Gln Leu Ala Pro Gly Gln Glu Val Trp Ala 
                805                 810                 815     


Asp Glu Leu Cys Gln Arg Arg Cys Thr Cys Asn Gly Ala Thr His Gln 
            820                 825                 830         


Val Thr Cys Arg Asp Lys Gln Ser Cys Pro Ala Gly Glu Arg Cys Ser 
        835                 840                 845             


Val Gln Asn Gly Leu Leu Gly Cys Tyr Pro Asp Arg Phe Gly Thr Cys 
    850                 855                 860                 


Gln Gly Ser Gly Asp Pro His Tyr Val Ser Phe Asp Gly Arg Arg Phe 
865                 870                 875                 880 


Asp Phe Met Gly Thr Cys Thr Tyr Leu Leu Val Gly Ser Cys Gly Gln 
                885                 890                 895     


Asn Ala Ala Leu Pro Ala Phe Arg Val Leu Val Glu Asn Glu His Arg 
            900                 905                 910         


Gly Ser Gln Thr Val Ser Tyr Thr Arg Ala Val Arg Val Glu Ala Arg 
        915                 920                 925             


Gly Val Lys Val Ala Val Arg Arg Glu Tyr Pro Gly Gln Val Leu Val 
    930                 935                 940                 


Asp Asp Val Leu Gln Tyr Leu Pro Phe Gln Ala Ala Asp Gly Gln Val 
945                 950                 955                 960 


Gln Val Phe Arg Gln Gly Arg Asp Ala Val Val Arg Thr Asp Phe Gly 
                965                 970                 975     


Leu Thr Val Thr Tyr Asp Trp Asn Ala Arg Val Thr Ala Lys Val Pro 
            980                 985                 990         


Ser Ser Tyr Ala Glu Ala Leu Cys  Gly Leu Cys Gly Asn  Phe Asn Gly 
        995                 1000                 1005             


Asp Pro  Ala Asp Asp Leu Ala  Leu Arg Gly Gly Gly  Gln Ala Ala 
    1010                 1015                 1020             


Asn Ala  Leu Ala Phe Gly Asn  Ser Trp Gln Glu Glu  Thr Arg Pro 
    1025                 1030                 1035             


Gly Cys  Gly Ala Thr Glu Pro  Gly Asp Cys Pro Lys  Leu Asp Ser 
    1040                 1045                 1050             


Leu Val  Ala Gln Gln Leu Gln  Ser Lys Asn Glu Cys  Gly Ile Leu 
    1055                 1060                 1065             


Ala Asp  Pro Lys Gly Pro Phe  Arg Glu Cys His Ser  Lys Leu Asp 
    1070                 1075                 1080             


Pro Gln  Gly Ala Val Arg Asp  Cys Val Tyr Asp Arg  Cys Leu Leu 
    1085                 1090                 1095             


Pro Gly  Gln Ser Gly Pro Leu  Cys Asp Ala Leu Ala  Thr Tyr Ala 
    1100                 1105                 1110             


Ala Ala  Cys Gln Ala Ala Gly  Ala Thr Val His Pro  Trp Arg Ser 
    1115                 1120                 1125             


Glu Glu  Leu Cys Pro Leu Ser  Cys Pro Pro His Ser  His Tyr Glu 
    1130                 1135                 1140             


Ala Cys  Ser Tyr Gly Cys Pro  Leu Ser Cys Gly Asp  Leu Pro Val 
    1145                 1150                 1155             


Pro Gly  Gly Cys Gly Ser Glu  Cys His Glu Gly Cys  Val Cys Asp 
    1160                 1165                 1170             


Glu Gly  Phe Ala Leu Ser Gly  Glu Ser Cys Leu Pro  Leu Ala Ser 
    1175                 1180                 1185             


Cys Gly  Cys Val His Gln Gly  Thr Tyr His Pro Pro  Gly Gln Thr 
    1190                 1195                 1200             


Phe Tyr  Pro Gly Pro Gly Cys  Asp Ser Leu Cys His  Cys Gln Glu 
    1205                 1210                 1215             


Gly Gly  Leu Val Ser Cys Glu  Ser Ser Ser Cys Gly  Pro His Glu 
    1220                 1225                 1230             


Ala Cys  Gln Pro Ser Gly Gly  Ser Leu Gly Cys Val  Ala Val Gly 
    1235                 1240                 1245             


Ser Ser  Thr Cys Gln Ala Ser  Gly Asp Pro His Tyr  Thr Thr Phe 
    1250                 1255                 1260             


Asp Gly  Arg Arg Phe Asp Phe  Met Gly Thr Cys Val  Tyr Val Leu 
    1265                 1270                 1275             


Ala Gln  Thr Cys Gly Thr Arg  Pro Gly Leu His Arg  Phe Ala Val 
    1280                 1285                 1290             


Leu Gln  Glu Asn Val Ala Trp  Gly Asn Gly Arg Val  Ser Val Thr 
    1295                 1300                 1305             


Arg Val  Ile Thr Val Gln Val  Ala Asn Phe Thr Leu  Arg Leu Glu 
    1310                 1315                 1320             


Gln Arg  Gln Trp Lys Val Thr  Val Asn Gly Val Asp  Met Lys Leu 
    1325                 1330                 1335             


Pro Val  Val Leu Ala Asn Gly  Gln Ile Arg Ala Ser  Gln His Gly 
    1340                 1345                 1350             


Ser Asp  Val Val Ile Glu Thr  Asp Phe Gly Leu Arg  Val Ala Tyr 
    1355                 1360                 1365             


Asp Leu  Val Tyr Tyr Val Arg  Val Thr Val Pro Gly  Asn Tyr Tyr 
    1370                 1375                 1380             


Gln Gln  Met Cys Gly Leu Cys  Gly Asn Tyr Asn Gly  Asp Pro Lys 
    1385                 1390                 1395             


Asp Asp  Phe Gln Lys Pro Asn  Gly Ser Gln Ala Gly  Asn Ala Asn 
    1400                 1405                 1410             


Glu Phe  Gly Asn Ser Trp Glu  Glu Val Val Pro Asp  Ser Pro Cys 
    1415                 1420                 1425             


Leu Pro  Pro Thr Pro Cys Pro  Pro Gly Ser Glu Asp  Cys Ile Pro 
    1430                 1435                 1440             


Ser His  Lys Cys Pro Pro Glu  Leu Glu Lys Lys Tyr  Gln Lys Glu 
    1445                 1450                 1455             


Glu Phe  Cys Gly Leu Leu Ser  Ser Pro Thr Gly Pro  Leu Ser Ser 
    1460                 1465                 1470             


Cys His  Lys Leu Val Asp Pro  Gln Gly Pro Leu Lys  Asp Cys Ile 
    1475                 1480                 1485             


Phe Asp  Leu Cys Leu Gly Gly  Gly Asn Leu Ser Ile  Leu Cys Ser 
    1490                 1495                 1500             


Asn Ile  His Ala Tyr Val Ser  Ala Cys Gln Ala Ala  Gly Gly His 
    1505                 1510                 1515             


Val Glu  Pro Trp Arg Thr Glu  Thr Phe Cys Pro Met  Glu Cys Pro 
    1520                 1525                 1530             


Pro Asn  Ser His Tyr Glu Leu  Cys Ala Asp Thr Cys  Ser Leu Gly 
    1535                 1540                 1545             


Cys Ser  Ala Leu Ser Ala Pro  Pro Gln Cys Gln Asp  Gly Cys Ala 
    1550                 1555                 1560             


Glu Gly  Cys Gln Cys Asp Ser  Gly Phe Leu Tyr Asn  Gly Gln Ala 
    1565                 1570                 1575             


Cys Val  Pro Ile Gln Gln Cys  Gly Cys Tyr His Asn  Gly Val Tyr 
    1580                 1585                 1590             


Tyr Glu  Pro Glu Gln Thr Val  Leu Ile Asp Asn Cys  Arg Gln Gln 
    1595                 1600                 1605             


Cys Thr  Cys His Ala Gly Lys  Gly Met Val Cys Gln  Glu His Ser 
    1610                 1615                 1620             


Cys Lys  Pro Gly Gln Val Cys  Gln Pro Ser Gly Gly  Ile Leu Ser 
    1625                 1630                 1635             


Cys Val  Thr Lys Asp Pro Cys  His Gly Val Thr Cys  Arg Pro Gln 
    1640                 1645                 1650             


Glu Thr  Cys Lys Glu Gln Gly  Gly Gln Gly Val Cys  Leu Pro Asn 
    1655                 1660                 1665             


Tyr Glu  Ala Thr Cys Trp Leu  Trp Gly Asp Pro His  Tyr His Ser 
    1670                 1675                 1680             


Phe Asp  Gly Arg Lys Phe Asp  Phe Gln Gly Thr Cys  Asn Tyr Val 
    1685                 1690                 1695             


Leu Ala  Thr Thr Gly Cys Pro  Gly Val Ser Thr Gln  Gly Leu Thr 
    1700                 1705                 1710             


Pro Phe  Thr Val Thr Thr Lys  Asn Gln Asn Arg Gly  Asn Pro Ala 
    1715                 1720                 1725             


Val Ser  Tyr Val Arg Val Val  Thr Val Ala Ala Leu  Gly Thr Asn 
    1730                 1735                 1740             


Ile Ser  Ile His Lys Asp Glu  Ile Gly Lys Val Arg  Val Asn Gly 
    1745                 1750                 1755             


Val Leu  Thr Ala Leu Pro Val  Ser Val Ala Asp Gly  Arg Ile Ser 
    1760                 1765                 1770             


Val Thr  Gln Gly Ala Ser Lys  Ala Leu Leu Val Ala  Asp Phe Gly 
    1775                 1780                 1785             


Leu Gln  Val Ser Tyr Asp Trp  Asn Trp Arg Val Asp  Val Thr Leu 
    1790                 1795                 1800             


Pro Ser  Ser Tyr His Gly Ala  Val Cys Gly Leu Cys  Gly Asn Met 
    1805                 1810                 1815             


Asp Arg  Asn Pro Asn Asn Asp  Gln Val Phe Pro Asn  Gly Thr Leu 
    1820                 1825                 1830             


Ala Pro  Ser Ile Pro Ile Trp  Gly Gly Ser Trp Arg  Ala Pro Gly 
    1835                 1840                 1845             


Trp Asp  Pro Leu Cys Trp Asp  Glu Cys Arg Gly Ser  Cys Pro Thr 
    1850                 1855                 1860             


Cys Pro  Glu Asp Arg Leu Glu  Gln Tyr Glu Gly Pro  Gly Phe Cys 
    1865                 1870                 1875             


Gly Pro  Leu Ala Pro Gly Thr  Gly Gly Pro Phe Thr  Thr Cys His 
    1880                 1885                 1890             


Ala His  Val Pro Pro Glu Ser  Phe Phe Lys Gly Cys  Val Leu Asp 
    1895                 1900                 1905             


Val Cys  Met Gly Gly Gly Asp  Arg Asp Ile Leu Cys  Lys Ala Leu 
    1910                 1915                 1920             


Ala Ser  Tyr Val Ala Ala Cys  Gln Ala Ala Gly Val  Val Ile Glu 
    1925                 1930                 1935             


Asp Trp  Arg Ala Gln Val Gly  Cys Glu Ile Thr Cys  Pro Glu Asn 
    1940                 1945                 1950             


Ser His  Tyr Glu Val Cys Gly  Ser Pro Cys Pro Ala  Ser Cys Pro 
    1955                 1960                 1965             


Ser Pro  Ala Pro Leu Thr Thr  Pro Ala Val Cys Glu  Gly Pro Cys 
    1970                 1975                 1980             


Val Glu  Gly Cys Gln Cys Asp  Ala Gly Phe Val Leu  Ser Ala Asp 
    1985                 1990                 1995             


Arg Cys  Val Pro Leu Asn Asn  Gly Cys Gly Cys Trp  Ala Asn Gly 
    2000                 2005                 2010             


Thr Tyr  His Glu Ala Gly Ser  Glu Phe Trp Ala Asp  Gly Thr Cys 
    2015                 2020                 2025             


Ser Gln  Trp Cys Arg Cys Gly  Pro Gly Gly Gly Ser  Leu Val Cys 
    2030                 2035                 2040             


Thr Pro  Ala Ser Cys Gly Leu  Gly Glu Val Cys Gly  Leu Leu Pro 
    2045                 2050                 2055             


Ser Gly  Gln His Gly Cys Gln  Pro Val Ser Thr Ala  Glu Cys Gln 
    2060                 2065                 2070             


Ala Trp  Gly Asp Pro His Tyr  Val Thr Leu Asp Gly  His Arg Phe 
    2075                 2080                 2085             


Asn Phe  Gln Gly Thr Cys Glu  Tyr Leu Leu Ser Ala  Pro Cys His 
    2090                 2095                 2100             


Gly Pro  Pro Leu Gly Ala Glu  Asn Phe Thr Val Thr  Val Ala Asn 
    2105                 2110                 2115             


Glu His  Arg Gly Ser Gln Ala  Val Ser Tyr Thr Arg  Ser Val Thr 
    2120                 2125                 2130             


Leu Gln  Ile Tyr Asn His Ser  Leu Thr Leu Ser Ala  Arg Trp Pro 
    2135                 2140                 2145             


Arg Lys  Leu Gln Val Asp Gly  Val Phe Val Thr Leu  Pro Phe Gln 
    2150                 2155                 2160             


Leu Asp  Ser Leu Leu His Ala  His Leu Ser Gly Ala  Asp Val Val 
    2165                 2170                 2175             


Val Thr  Thr Thr Ser Gly Leu  Ser Leu Ala Phe Asp  Gly Asp Ser 
    2180                 2185                 2190             


Phe Val  Arg Leu Arg Val Pro  Ala Ala Tyr Ala Gly  Ser Leu Cys 
    2195                 2200                 2205             


Gly Leu  Cys Gly Asn Tyr Asn  Gln Asp Pro Ala Asp  Asp Leu Lys 
    2210                 2215                 2220             


Ala Val  Gly Gly Lys Pro Ala  Gly Trp Gln Val Gly  Gly Ala Gln 
    2225                 2230                 2235             


Gly Cys  Gly Glu Cys Val Ser  Lys Pro Cys Pro Ser  Pro Cys Thr 
    2240                 2245                 2250             


Pro Glu  Gln Gln Glu Ser Phe  Gly Gly Pro Asp Ala  Cys Gly Val 
    2255                 2260                 2265             


Ile Ser  Ala Thr Asp Gly Pro  Leu Ala Pro Cys His  Gly Leu Val 
    2270                 2275                 2280             


Pro Pro  Ala Gln Tyr Phe Gln  Gly Cys Leu Leu Asp  Ala Cys Gln 
    2285                 2290                 2295             


Val Gln  Gly His Pro Gly Gly  Leu Cys Pro Ala Val  Ala Thr Tyr 
    2300                 2305                 2310             


Val Ala  Ala Cys Gln Ala Ala  Gly Ala Gln Leu Arg  Glu Trp Arg 
    2315                 2320                 2325             


Arg Pro  Asp Phe Cys Pro Phe  Gln Cys Pro Ala His  Ser His Tyr 
    2330                 2335                 2340             


Glu Leu  Cys Gly Asp Ser Cys  Pro Gly Ser Cys Pro  Ser Leu Ser 
    2345                 2350                 2355             


Ala Pro  Glu Gly Cys Glu Ser  Ala Cys Arg Glu Gly  Cys Val Cys 
    2360                 2365                 2370             


Asp Ala  Gly Phe Val Leu Ser  Gly Asp Thr Cys Val  Pro Val Gly 
    2375                 2380                 2385             


Gln Cys  Gly Cys Leu His Asp  Asp Arg Tyr Tyr Pro  Leu Gly Gln 
    2390                 2395                 2400             


Thr Phe  Tyr Pro Gly Pro Gly  Cys Asp Ser Leu Cys  Arg Cys Arg 
    2405                 2410                 2415             


Glu Gly  Gly Glu Val Ser Cys  Glu Pro Ser Ser Cys  Gly Pro His 
    2420                 2425                 2430             


Glu Thr  Cys Arg Pro Ser Gly  Gly Ser Leu Gly Cys  Val Ala Val 
    2435                 2440                 2445             


Gly Ser  Thr Thr Cys Gln Ala  Ser Gly Asp Pro His  Tyr Thr Thr 
    2450                 2455                 2460             


Phe Asp  Gly Arg Arg Phe Asp  Phe Met Gly Thr Cys  Val Tyr Val 
    2465                 2470                 2475             


Leu Ala  Gln Thr Cys Gly Thr  Arg Pro Gly Leu His  Arg Phe Ala 
    2480                 2485                 2490             


Val Leu  Gln Glu Asn Val Ala  Trp Gly Asn Gly Arg  Val Ser Val 
    2495                 2500                 2505             


Thr Arg  Val Ile Thr Val Gln  Val Ala Asn Phe Thr  Leu Arg Leu 
    2510                 2515                 2520             


Glu Gln  Arg Gln Trp Lys Val  Thr Val Asn Gly Val  Asp Met Lys 
    2525                 2530                 2535             


Leu Pro  Val Val Leu Ala Asn  Gly Gln Ile Arg Ala  Ser Gln His 
    2540                 2545                 2550             


Gly Ser  Asp Val Val Ile Glu  Thr Asp Phe Gly Leu  Arg Val Ala 
    2555                 2560                 2565             


Tyr Asp  Leu Val Tyr Tyr Val  Arg Val Thr Val Pro  Gly Asn Tyr 
    2570                 2575                 2580             


Tyr Gln  Leu Met Cys Gly Leu  Cys Gly Asn Tyr Asn  Gly Asp Pro 
    2585                 2590                 2595             


Lys Asp  Asp Phe Gln Lys Pro  Asn Gly Ser Gln Ala  Gly Asn Ala 
    2600                 2605                 2610             


Asn Glu  Phe Gly Asn Ser Trp  Glu Glu Val Val Pro  Asp Ser Pro 
    2615                 2620                 2625             


Cys Leu  Pro Pro Pro Thr Cys  Pro Pro Gly Ser Glu  Gly Cys Ile 
    2630                 2635                 2640             


Pro Ser  Glu Glu Cys Pro Pro  Glu Leu Glu Lys Lys  Tyr Gln Lys 
    2645                 2650                 2655             


Glu Glu  Phe Cys Gly Leu Leu  Ser Ser Pro Thr Gly  Pro Leu Ser 
    2660                 2665                 2670             


Ser Cys  His Lys Leu Val Asp  Pro Gln Gly Pro Leu  Lys Asp Cys 
    2675                 2680                 2685             


Ile Phe  Asp Leu Cys Leu Gly  Gly Gly Asn Leu Ser  Ile Leu Cys 
    2690                 2695                 2700             


Ser Asn  Ile His Ala Tyr Val  Ser Ala Cys Gln Ala  Ala Gly Gly 
    2705                 2710                 2715             


Gln Val  Glu Pro Trp Arg Asn  Glu Thr Phe Cys Pro  Met Glu Cys 
    2720                 2725                 2730             


Pro Gln  Asn Ser His Tyr Glu  Leu Cys Ala Asp Thr  Cys Ser Leu 
    2735                 2740                 2745             


Gly Cys  Ser Ala Leu Ser Ala  Pro Leu Gln Cys Pro  Asp Gly Cys 
    2750                 2755                 2760             


Ala Glu  Gly Cys Gln Cys Asp  Ser Gly Phe Leu Tyr  Asn Gly Gln 
    2765                 2770                 2775             


Ala Cys  Val Pro Ile Gln Gln  Cys Gly Cys Tyr His  Asn Gly Ala 
    2780                 2785                 2790             


Tyr Tyr  Glu Pro Glu Gln Thr  Val Leu Ile Asp Asn  Cys Arg Gln 
    2795                 2800                 2805             


Gln Cys  Thr Cys His Val Gly  Lys Val Val Val Cys  Gln Glu His 
    2810                 2815                 2820             


Ser Cys  Lys Pro Gly Gln Val  Cys Gln Pro Ser Gly  Gly Ile Leu 
    2825                 2830                 2835             


Ser Cys  Val Asn Lys Asp Pro  Cys His Gly Val Thr  Cys Arg Pro 
    2840                 2845                 2850             


Gln Glu  Thr Cys Lys Glu Gln  Gly Gly Gln Gly Val  Cys Leu Pro 
    2855                 2860                 2865             


Asn Tyr  Glu Ala Thr Cys Trp  Leu Trp Gly Asp Pro  His Tyr His 
    2870                 2875                 2880             


Ser Phe  Asp Gly Arg Lys Phe  Asp Phe Gln Gly Thr  Cys Asn Tyr 
    2885                 2890                 2895             


Val Leu  Ala Thr Thr Gly Cys  Pro Gly Val Ser Thr  Gln Gly Leu 
    2900                 2905                 2910             


Thr Pro  Phe Thr Val Thr Thr  Lys Asn Gln Asn Arg  Gly Asn Pro 
    2915                 2920                 2925             


Ala Val  Ser Tyr Val Arg Val  Val Thr Val Ala Ala  Leu Gly Thr 
    2930                 2935                 2940             


Asn Ile  Ser Ile His Lys Asp  Glu Ile Gly Lys Val  Arg Val Asn 
    2945                 2950                 2955             


Gly Val  Leu Thr Ala Leu Pro  Val Ser Val Ala Asp  Gly Arg Ile 
    2960                 2965                 2970             


Ser Val  Thr Gln Gly Ala Ser  Lys Ala Leu Leu Val  Ala Asp Phe 
    2975                 2980                 2985             


Gly Leu  Gln Val Ser Tyr Asp  Trp Asn Trp Arg Val  Asp Val Thr 
    2990                 2995                 3000             


Leu Pro  Ser Ser Tyr His Gly  Ala Val Cys Gly Leu  Cys Gly Asn 
    3005                 3010                 3015             


Met Asp  Arg Asn Pro Asn Asn  Asp Gln Val Phe Pro  Asn Gly Thr 
    3020                 3025                 3030             


Leu Ala  Pro Ser Ile Pro Ile  Trp Gly Gly Ser Trp  Arg Ala Pro 
    3035                 3040                 3045             


Gly Trp  Asp Pro Leu Cys Trp  Asp Glu Cys Arg Gly  Ser Cys Pro 
    3050                 3055                 3060             


Thr Cys  Pro Glu Asp Arg Leu  Glu Gln Tyr Glu Gly  Pro Gly Phe 
    3065                 3070                 3075             


Cys Gly  Pro Leu Ala Pro Gly  Thr Gly Gly Pro Phe  Thr Thr Cys 
    3080                 3085                 3090             


His Ala  His Val Pro Pro Glu  Ser Phe Phe Lys Gly  Cys Val Leu 
    3095                 3100                 3105             


Asp Val  Cys Met Gly Gly Gly  Asp Arg Asp Ile Leu  Cys Lys Ala 
    3110                 3115                 3120             


Leu Ala  Ser Tyr Val Ala Ala  Cys Gln Ala Ala Gly  Val Val Ile 
    3125                 3130                 3135             


Glu Asp  Trp Arg Ala Gln Val  Gly Cys Glu Ile Thr  Cys Pro Glu 
    3140                 3145                 3150             


Asn Ser  His Tyr Glu Val Cys  Gly Pro Pro Cys Pro  Ala Ser Cys 
    3155                 3160                 3165             


Pro Ser  Pro Ala Pro Leu Thr  Thr Pro Ala Val Cys  Glu Gly Pro 
    3170                 3175                 3180             


Cys Val  Glu Gly Cys Gln Cys  Asp Ala Gly Phe Val  Leu Ser Ala 
    3185                 3190                 3195             


Asp Arg  Cys Val Pro Leu Asn  Asn Gly Cys Gly Cys  Trp Ala Asn 
    3200                 3205                 3210             


Gly Thr  Tyr His Glu Ala Gly  Ser Glu Phe Trp Ala  Asp Gly Thr 
    3215                 3220                 3225             


Cys Ser  Gln Trp Cys Arg Cys  Gly Pro Gly Gly Gly  Ser Leu Val 
    3230                 3235                 3240             


Cys Thr  Pro Ala Ser Cys Gly  Leu Gly Glu Val Cys  Gly Leu Leu 
    3245                 3250                 3255             


Pro Ser  Gly Gln His Gly Cys  Gln Pro Val Ser Thr  Ala Glu Cys 
    3260                 3265                 3270             


Gln Ala  Trp Gly Asp Pro His  Tyr Val Thr Leu Asp  Gly His Arg 
    3275                 3280                 3285             


Phe Asp  Phe Gln Gly Thr Cys  Glu Tyr Leu Leu Ser  Ala Pro Cys 
    3290                 3295                 3300             


His Gly  Pro Pro Leu Gly Ala  Glu Asn Phe Thr Val  Thr Val Ala 
    3305                 3310                 3315             


Asn Glu  His Arg Gly Ser Gln  Ala Val Ser Tyr Thr  Arg Ser Val 
    3320                 3325                 3330             


Thr Leu  Gln Ile Tyr Asn His  Ser Leu Thr Leu Ser  Ala Arg Trp 
    3335                 3340                 3345             


Pro Arg  Lys Leu Gln Val Asp  Gly Val Phe Val Thr  Leu Pro Phe 
    3350                 3355                 3360             


Gln Leu  Asp Ser Leu Leu His  Ala His Leu Ser Gly  Ala Asp Val 
    3365                 3370                 3375             


Val Val  Thr Thr Thr Ser Gly  Leu Ser Leu Ala Phe  Asp Gly Asp 
    3380                 3385                 3390             


Ser Phe  Val Arg Leu Arg Val  Pro Ala Ala Tyr Ala  Gly Ser Leu 
    3395                 3400                 3405             


Cys Gly  Leu Cys Gly Asn Tyr  Asn Gln Asp Pro Ala  Asp Asp Leu 
    3410                 3415                 3420             


Lys Ala  Val Gly Gly Lys Pro  Ala Gly Trp Gln Val  Gly Gly Ala 
    3425                 3430                 3435             


Gln Gly  Cys Gly Glu Cys Val  Ser Lys Pro Cys Pro  Ser Pro Cys 
    3440                 3445                 3450             


Thr Pro  Glu Gln Gln Glu Ser  Phe Gly Gly Pro Asp  Ala Cys Gly 
    3455                 3460                 3465             


Val Ile  Ser Ala Thr Asp Gly  Pro Leu Ala Pro Cys  His Gly Leu 
    3470                 3475                 3480             


Val Pro  Pro Ala Gln Tyr Phe  Gln Gly Cys Leu Leu  Asp Ala Cys 
    3485                 3490                 3495             


Gln Val  Gln Gly His Pro Gly  Gly Leu Cys Pro Ala  Val Ala Thr 
    3500                 3505                 3510             


Tyr Val  Ala Ala Cys Gln Ala  Ala Gly Ala Gln Leu  Arg Glu Trp 
    3515                 3520                 3525             


Arg Arg  Pro Asp Phe Cys Pro  Phe Gln Cys Pro Ala  His Ser His 
    3530                 3535                 3540             


Tyr Glu  Leu Cys Gly Asp Ser  Cys Pro Gly Ser Cys  Pro Ser Leu 
    3545                 3550                 3555             


Ser Ala  Pro Glu Gly Cys Glu  Ser Ala Cys Arg Glu  Gly Cys Val 
    3560                 3565                 3570             


Cys Asp  Ala Gly Phe Val Leu  Ser Gly Asp Thr Cys  Val Pro Val 
    3575                 3580                 3585             


Gly Gln  Cys Gly Cys Leu His  Asp Asp Arg Tyr Tyr  Pro Leu Gly 
    3590                 3595                 3600             


Gln Thr  Phe Tyr Pro Gly Pro  Gly Cys Asp Ser Leu  Cys Arg Cys 
    3605                 3610                 3615             


Arg Glu  Gly Gly Glu Val Ser  Cys Glu Pro Ser Ser  Cys Gly Pro 
    3620                 3625                 3630             


His Glu  Thr Cys Arg Pro Ser  Gly Gly Ser Leu Gly  Cys Val Ala 
    3635                 3640                 3645             


Val Gly  Ser Thr Thr Cys Gln  Ala Ser Gly Asp Pro  His Tyr Thr 
    3650                 3655                 3660             


Thr Phe  Asp Gly His Arg Phe  Asp Phe Met Gly Thr  Cys Val Tyr 
    3665                 3670                 3675             


Val Leu  Ala Gln Thr Cys Gly  Thr Arg Pro Gly Leu  His Arg Phe 
    3680                 3685                 3690             


Ala Val  Leu Gln Glu Asn Val  Ala Trp Gly Asn Gly  Arg Val Ser 
    3695                 3700                 3705             


Val Thr  Arg Val Ile Thr Val  Gln Val Ala Asn Phe  Thr Leu Arg 
    3710                 3715                 3720             


Leu Glu  Gln Arg Gln Trp Lys  Val Thr Val Asn Gly  Val Asp Met 
    3725                 3730                 3735             


Lys Leu  Pro Val Val Leu Ala  Asn Gly Gln Ile Arg  Ala Ser Gln 
    3740                 3745                 3750             


His Gly  Ser Asp Val Val Ile  Glu Thr Asp Phe Gly  Leu Arg Val 
    3755                 3760                 3765             


Ala Tyr  Asp Leu Val Tyr Tyr  Val Arg Val Thr Val  Pro Gly Asn 
    3770                 3775                 3780             


Tyr Tyr  Gln Leu Met Cys Gly  Leu Cys Gly Asn Tyr  Asn Gly Asp 
    3785                 3790                 3795             


Pro Lys  Asp Asp Phe Gln Lys  Pro Asn Gly Ser Gln  Ala Gly Asn 
    3800                 3805                 3810             


Ala Asn  Glu Phe Gly Asn Ser  Trp Glu Glu Val Val  Pro Asp Ser 
    3815                 3820                 3825             


Pro Cys  Leu Pro Pro Pro Thr  Cys Pro Pro Gly Ser  Ala Gly Cys 
    3830                 3835                 3840             


Ile Pro  Ser Asp Lys Cys Pro  Pro Glu Leu Glu Lys  Lys Tyr Gln 
    3845                 3850                 3855             


Lys Glu  Glu Phe Cys Gly Leu  Leu Ser Ser Pro Thr  Gly Pro Leu 
    3860                 3865                 3870             


Ser Ser  Cys His Lys Leu Val  Asp Pro Gln Gly Pro  Leu Lys Asp 
    3875                 3880                 3885             


Cys Ile  Phe Asp Leu Cys Leu  Gly Gly Gly Asn Leu  Ser Ile Leu 
    3890                 3895                 3900             


Cys Ser  Asn Ile His Ala Tyr  Val Ser Ala Cys Gln  Ala Ala Gly 
    3905                 3910                 3915             


Gly His  Val Glu Pro Trp Arg  Asn Glu Thr Phe Cys  Pro Met Glu 
    3920                 3925                 3930             


Cys Pro  Gln Asn Ser His Tyr  Glu Leu Cys Ala Asp  Thr Cys Ser 
    3935                 3940                 3945             


Leu Gly  Cys Ser Ala Leu Ser  Ala Pro Leu Gln Cys  Pro Asp Gly 
    3950                 3955                 3960             


Cys Ala  Glu Gly Cys Gln Cys  Asp Ser Gly Phe Leu  Tyr Asn Gly 
    3965                 3970                 3975             


Gln Ala  Cys Val Pro Ile Gln  Gln Cys Gly Cys Tyr  His Asn Gly 
    3980                 3985                 3990             


Val Tyr  Tyr Glu Pro Glu Gln  Thr Val Leu Ile Asp  Asn Cys Arg 
    3995                 4000                 4005             


Gln Gln  Cys Thr Cys His Val  Gly Lys Val Val Val  Cys Gln Glu 
    4010                 4015                 4020             


His Ser  Cys Lys Pro Gly Gln  Val Cys Gln Pro Ser  Gly Gly Ile 
    4025                 4030                 4035             


Leu Ser  Cys Val Thr Lys Asp  Pro Cys His Gly Val  Thr Cys Arg 
    4040                 4045                 4050             


Pro Gln  Glu Thr Cys Lys Glu  Gln Gly Gly Gln Gly  Val Cys Leu 
    4055                 4060                 4065             


Pro Asn  Tyr Glu Ala Thr Cys  Trp Leu Trp Gly Asp  Pro His Tyr 
    4070                 4075                 4080             


His Ser  Phe Asp Gly Arg Lys  Phe Asp Phe Gln Gly  Thr Cys Asn 
    4085                 4090                 4095             


Tyr Val  Leu Ala Thr Thr Gly  Cys Pro Gly Val Ser  Thr Gln Gly 
    4100                 4105                 4110             


Leu Thr  Pro Phe Thr Val Thr  Thr Lys Asn Gln Asn  Arg Gly Asn 
    4115                 4120                 4125             


Pro Ala  Val Ser Tyr Val Arg  Val Val Thr Val Ala  Ala Leu Gly 
    4130                 4135                 4140             


Thr Asn  Ile Ser Ile His Lys  Asp Glu Ile Gly Lys  Val Arg Val 
    4145                 4150                 4155             


Asn Gly  Val Leu Thr Ala Leu  Pro Val Ser Val Ala  Asp Gly Arg 
    4160                 4165                 4170             


Ile Ser  Val Ala Gln Gly Ala  Ser Lys Ala Leu Leu  Val Ala Asp 
    4175                 4180                 4185             


Phe Gly  Leu Gln Val Ser Tyr  Asp Trp Asn Trp Arg  Val Asp Val 
    4190                 4195                 4200             


Thr Leu  Pro Ser Ser Tyr His  Gly Ala Val Cys Gly  Leu Cys Gly 
    4205                 4210                 4215             


Asn Met  Asp Arg Asn Pro Asn  Asn Asp Gln Val Phe  Pro Asn Gly 
    4220                 4225                 4230             


Thr Leu  Ala Pro Ser Ile Pro  Ile Trp Gly Gly Ser  Trp Arg Ala 
    4235                 4240                 4245             


Pro Gly  Trp Asp Pro Leu Cys  Trp Asp Glu Cys Arg  Gly Ser Cys 
    4250                 4255                 4260             


Pro Thr  Cys Pro Glu Asp Arg  Leu Glu Gln Tyr Glu  Gly Pro Gly 
    4265                 4270                 4275             


Phe Cys  Gly Pro Leu Ser Ser  Gly Thr Gly Gly Pro  Phe Thr Thr 
    4280                 4285                 4290             


Cys His  Ala His Val Pro Pro  Glu Ser Phe Phe Lys  Gly Cys Val 
    4295                 4300                 4305             


Leu Asp  Val Cys Met Gly Gly  Gly Asp Arg Asp Ile  Leu Cys Lys 
    4310                 4315                 4320             


Ala Leu  Ala Ser Tyr Val Ala  Ala Cys Gln Ala Ala  Gly Val Val 
    4325                 4330                 4335             


Ile Glu  Asp Trp Arg Ala Gln  Val Gly Cys Glu Ile  Thr Cys Pro 
    4340                 4345                 4350             


Glu Asn  Ser His Tyr Glu Val  Cys Gly Pro Pro Cys  Pro Ala Ser 
    4355                 4360                 4365             


Cys Pro  Ser Pro Ala Pro Leu  Thr Thr Pro Ala Val  Cys Glu Gly 
    4370                 4375                 4380             


Pro Cys  Val Glu Gly Cys Gln  Cys Asp Ala Gly Phe  Val Leu Ser 
    4385                 4390                 4395             


Ala Asp  Arg Cys Val Pro Leu  Asn Asn Gly Cys Gly  Cys Trp Ala 
    4400                 4405                 4410             


Asn Gly  Thr Tyr His Glu Ala  Gly Ser Glu Phe Trp  Ala Asp Gly 
    4415                 4420                 4425             


Thr Cys  Ser Gln Trp Cys Arg  Cys Gly Pro Gly Gly  Gly Ser Leu 
    4430                 4435                 4440             


Val Cys  Thr Pro Ala Ser Cys  Gly Leu Gly Glu Val  Cys Gly Leu 
    4445                 4450                 4455             


Leu Pro  Ser Gly Gln His Gly  Cys Gln Pro Val Ser  Thr Ala Glu 
    4460                 4465                 4470             


Cys Gln  Ala Trp Gly Asp Pro  His Tyr Val Thr Leu  Asp Gly His 
    4475                 4480                 4485             


Arg Phe  Asp Phe Gln Gly Thr  Cys Glu Tyr Leu Leu  Ser Ala Pro 
    4490                 4495                 4500             


Cys His  Gly Pro Pro Leu Gly  Ala Glu Asn Phe Thr  Val Thr Val 
    4505                 4510                 4515             


Ala Asn  Glu His Arg Gly Ser  Gln Ala Val Ser Tyr  Thr Arg Ser 
    4520                 4525                 4530             


Val Thr  Leu Gln Ile Tyr Asn  His Ser Leu Thr Leu  Ser Ala Arg 
    4535                 4540                 4545             


Trp Pro  Arg Lys Leu Gln Val  Asp Gly Val Phe Val  Ala Leu Pro 
    4550                 4555                 4560             


Phe Gln  Leu Asp Ser Leu Leu  His Ala His Leu Ser  Gly Ala Asp 
    4565                 4570                 4575             


Val Val  Val Thr Thr Thr Ser  Gly Leu Ser Leu Ala  Phe Asp Gly 
    4580                 4585                 4590             


Asp Ser  Phe Val Arg Leu Arg  Val Pro Ala Ala Tyr  Ala Ala Ser 
    4595                 4600                 4605             


Leu Cys  Gly Leu Cys Gly Asn  Tyr Asn Gln Asp Pro  Ala Asp Asp 
    4610                 4615                 4620             


Leu Lys  Ala Val Gly Gly Lys  Pro Ala Gly Trp Gln  Val Gly Gly 
    4625                 4630                 4635             


Ala Gln  Gly Cys Gly Glu Cys  Val Ser Lys Pro Cys  Pro Ser Pro 
    4640                 4645                 4650             


Cys Thr  Pro Glu Gln Gln Glu  Ser Phe Gly Gly Pro  Asp Ala Cys 
    4655                 4660                 4665             


Gly Val  Ile Ser Ala Thr Asp  Gly Pro Leu Ala Pro  Cys His Gly 
    4670                 4675                 4680             


Leu Val  Pro Pro Ala Gln Tyr  Phe Gln Gly Cys Leu  Leu Asp Ala 
    4685                 4690                 4695             


Cys Gln  Val Gln Gly His Pro  Gly Gly Leu Cys Pro  Ala Val Ala 
    4700                 4705                 4710             


Thr Tyr  Val Ala Ala Cys Gln  Ala Ala Gly Ala Gln  Leu Gly Glu 
    4715                 4720                 4725             


Trp Arg  Arg Pro Asp Phe Cys  Pro Leu Gln Cys Pro  Ala His Ser 
    4730                 4735                 4740             


His Tyr  Glu Leu Cys Gly Asp  Ser Cys Pro Val Ser  Cys Pro Ser 
    4745                 4750                 4755             


Leu Ser  Ala Pro Glu Gly Cys  Glu Ser Ala Cys Arg  Glu Gly Cys 
    4760                 4765                 4770             


Val Cys  Asp Ala Gly Phe Val  Leu Ser Gly Asp Thr  Cys Val Pro 
    4775                 4780                 4785             


Val Gly  Gln Cys Gly Cys Leu  His Asp Gly Arg Tyr  Tyr Pro Leu 
    4790                 4795                 4800             


Gly Glu  Val Phe Tyr Pro Gly  Pro Glu Cys Glu Arg  Arg Cys Glu 
    4805                 4810                 4815             


Cys Gly  Pro Gly Gly His Val  Thr Cys Gln Glu Gly  Ala Ala Cys 
    4820                 4825                 4830             


Gly Pro  His Glu Glu Cys Arg  Leu Glu Asp Gly Val  Gln Ala Cys 
    4835                 4840                 4845             


His Ala  Thr Gly Cys Gly Arg  Cys Leu Ala Asn Gly  Gly Ile His 
    4850                 4855                 4860             


Tyr Ile  Thr Leu Asp Gly Arg  Val Tyr Asp Leu His  Gly Ser Cys 
    4865                 4870                 4875             


Ser Tyr  Val Leu Ala Gln Val  Cys His Pro Lys Pro  Gly Asp Glu 
    4880                 4885                 4890             


Asp Phe  Ser Ile Val Leu Glu  Lys Asn Ala Ala Gly  Asp Leu Gln 
    4895                 4900                 4905             


Arg Leu  Leu Val Thr Val Ala  Gly Gln Val Val Ser  Leu Ala Gln 
    4910                 4915                 4920             


Gly Gln  Gln Val Thr Val Asp  Gly Glu Ala Val Ala  Leu Pro Val 
    4925                 4930                 4935             


Ala Val  Gly Arg Val Arg Val  Thr Ala Glu Gly Arg  Asn Met Val 
    4940                 4945                 4950             


Leu Gln  Thr Thr Lys Gly Leu  Arg Leu Leu Phe Asp  Gly Asp Ala 
    4955                 4960                 4965             


His Leu  Leu Met Ser Ile Pro  Ser Pro Phe Arg Gly  Arg Leu Cys 
    4970                 4975                 4980             


Gly Leu  Cys Gly Asn Phe Asn  Gly Asn Trp Ser Asp  Asp Phe Val 
    4985                 4990                 4995             


Leu Pro  Asn Gly Ser Ala Ala  Ser Ser Val Glu Thr  Phe Gly Ala 
    5000                 5005                 5010             


Ala Trp  Arg Ala Pro Gly Ser  Ser Lys Gly Cys Gly  Glu Gly Cys 
    5015                 5020                 5025             


Gly Pro  Gln Gly Cys Pro Val  Cys Leu Ala Glu Glu  Thr Ala Pro 
    5030                 5035                 5040             


Tyr Glu  Ser Asn Glu Ala Cys  Gly Gln Leu Arg Asn  Pro Gln Gly 
    5045                 5050                 5055             


Pro Phe  Ala Thr Cys Gln Ala  Val Leu Ser Pro Ser  Glu Tyr Phe 
    5060                 5065                 5070             


Arg Gln  Cys Val Tyr Asp Leu  Cys Ala Gln Lys Gly  Asp Lys Ala 
    5075                 5080                 5085             


Phe Leu  Cys Arg Ser Leu Ala  Ala Tyr Thr Ala Ala  Cys Gln Ala 
    5090                 5095                 5100             


Ala Gly  Val Ala Val Lys Pro  Trp Arg Thr Asp Ser  Phe Cys Pro 
    5105                 5110                 5115             


Leu His  Cys Pro Ala His Ser  His Tyr Ser Ile Cys  Thr Arg Thr 
    5120                 5125                 5130             


Cys Gln  Gly Ser Cys Ala Ala  Leu Ser Gly Leu Thr  Gly Cys Thr 
    5135                 5140                 5145             


Thr Arg  Cys Phe Glu Gly Cys  Glu Cys Asp Asp Arg  Phe Leu Leu 
    5150                 5155                 5160             


Ser Gln  Gly Val Cys Ile Pro  Val Gln Asp Cys Gly  Cys Thr His 
    5165                 5170                 5175             


Asn Gly  Arg Tyr Leu Pro Val  Asn Ser Ser Leu Leu  Thr Ser Asp 
    5180                 5185                 5190             


Cys Ser  Glu Arg Cys Ser Cys  Ser Ser Ser Ser Gly  Leu Thr Cys 
    5195                 5200                 5205             


Gln Ala  Ala Gly Cys Pro Pro  Gly Arg Val Cys Glu  Val Lys Ala 
    5210                 5215                 5220             


Glu Ala  Arg Asn Cys Trp Ala  Thr Arg Gly Leu Cys  Val Leu Ser 
    5225                 5230                 5235             


Val Gly  Ala Asn Leu Thr Thr  Phe Asp Gly Ala Arg  Gly Ala Thr 
    5240                 5245                 5250             


Thr Ser  Pro Gly Val Tyr Glu  Leu Ser Ser Arg Cys  Pro Gly Leu 
    5255                 5260                 5265             


Gln Asn  Thr Ile Pro Trp Tyr  Arg Val Val Ala Glu  Val Gln Ile 
    5270                 5275                 5280             


Cys His  Gly Lys Thr Glu Ala  Val Gly Gln Val His  Ile Phe Phe 
    5285                 5290                 5295             


Gln Asp  Gly Met Val Thr Leu  Thr Pro Asn Lys Gly  Val Trp Val 
    5300                 5305                 5310             


Asn Gly  Leu Arg Val Asp Leu  Pro Ala Glu Lys Leu  Ala Ser Val 
    5315                 5320                 5325             


Ser Val  Ser Arg Thr Pro Asp  Gly Ser Leu Leu Val  Arg Gln Lys 
    5330                 5335                 5340             


Ala Gly  Val Gln Val Trp Leu  Gly Ala Asn Gly Lys  Val Ala Val 
    5345                 5350                 5355             


Ile Val  Ser Asn Asp His Ala  Gly Lys Leu Cys Gly  Ala Cys Gly 
    5360                 5365                 5370             


Asn Phe  Asp Gly Asp Gln Thr  Asn Asp Trp His Asp  Ser Gln Glu 
    5375                 5380                 5385             


Lys Pro  Ala Met Glu Lys Trp  Arg Ala Gln Asp Phe  Ser Pro Cys 
    5390                 5395                 5400             


Tyr Gly  
    5405 


<210>  106
<211>  979
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Ala Leu Phe Ala Val Phe Gln Thr Thr Phe Phe Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Thr Tyr Gln Ser Glu Val Leu Ala Glu Arg Leu Pro Leu 
            20                  25                  30          


Thr Pro Val Ser Leu Lys Val Ser Thr Asn Ser Thr Arg Gln Ser Leu 
        35                  40                  45              


His Leu Gln Trp Thr Val His Asn Leu Pro Tyr His Gln Glu Leu Lys 
    50                  55                  60                  


Met Val Phe Gln Ile Gln Ile Ser Arg Ile Glu Thr Ser Asn Val Ile 
65                  70                  75                  80  


Trp Val Gly Asn Tyr Ser Thr Thr Val Lys Trp Asn Gln Val Leu His 
                85                  90                  95      


Trp Ser Trp Glu Ser Glu Leu Pro Leu Glu Cys Ala Thr His Phe Val 
            100                 105                 110         


Arg Ile Lys Ser Leu Val Asp Asp Ala Lys Phe Pro Glu Pro Asn Phe 
        115                 120                 125             


Trp Ser Asn Trp Ser Ser Trp Glu Glu Val Ser Val Gln Asp Ser Thr 
    130                 135                 140                 


Gly Gln Asp Ile Leu Phe Val Phe Pro Lys Asp Lys Leu Val Glu Glu 
145                 150                 155                 160 


Gly Thr Asn Val Thr Ile Cys Tyr Val Ser Arg Asn Ile Gln Asn Asn 
                165                 170                 175     


Val Ser Cys Tyr Leu Glu Gly Lys Gln Ile His Gly Glu Gln Leu Asp 
            180                 185                 190         


Pro His Val Thr Ala Phe Asn Leu Asn Ser Val Pro Phe Ile Arg Asn 
        195                 200                 205             


Lys Gly Thr Asn Ile Tyr Cys Glu Ala Ser Gln Gly Asn Val Ser Glu 
    210                 215                 220                 


Gly Met Lys Gly Ile Val Leu Phe Val Ser Lys Val Leu Glu Glu Pro 
225                 230                 235                 240 


Lys Asp Phe Ser Cys Glu Thr Glu Asp Phe Lys Thr Leu His Cys Thr 
                245                 250                 255     


Trp Asp Pro Gly Thr Asp Thr Ala Leu Gly Trp Ser Lys Gln Pro Ser 
            260                 265                 270         


Gln Ser Tyr Thr Leu Phe Glu Ser Phe Ser Gly Glu Lys Lys Leu Cys 
        275                 280                 285             


Thr His Lys Asn Trp Cys Asn Trp Gln Ile Thr Gln Asp Ser Gln Glu 
    290                 295                 300                 


Thr Tyr Asn Phe Thr Leu Ile Ala Glu Asn Tyr Leu Arg Lys Arg Ser 
305                 310                 315                 320 


Val Asn Ile Leu Phe Asn Leu Thr His Arg Val Tyr Leu Met Asn Pro 
                325                 330                 335     


Phe Ser Val Asn Phe Glu Asn Val Asn Ala Thr Asn Ala Ile Met Thr 
            340                 345                 350         


Trp Lys Val His Ser Ile Arg Asn Asn Phe Thr Tyr Leu Cys Gln Ile 
        355                 360                 365             


Glu Leu His Gly Glu Gly Lys Met Met Gln Tyr Asn Val Ser Ile Lys 
    370                 375                 380                 


Val Asn Gly Glu Tyr Phe Leu Ser Glu Leu Glu Pro Ala Thr Glu Tyr 
385                 390                 395                 400 


Met Ala Arg Val Arg Cys Ala Asp Ala Ser His Phe Trp Lys Trp Ser 
                405                 410                 415     


Glu Trp Ser Gly Gln Asn Phe Thr Thr Leu Glu Ala Ala Pro Ser Glu 
            420                 425                 430         


Ala Pro Asp Val Trp Arg Ile Val Ser Leu Glu Pro Gly Asn His Thr 
        435                 440                 445             


Val Thr Leu Phe Trp Lys Pro Leu Ser Lys Leu His Ala Asn Gly Lys 
    450                 455                 460                 


Ile Leu Phe Tyr Asn Val Val Val Glu Asn Leu Asp Lys Pro Ser Ser 
465                 470                 475                 480 


Ser Glu Leu His Ser Ile Pro Ala Pro Ala Asn Ser Thr Lys Leu Ile 
                485                 490                 495     


Leu Asp Arg Cys Ser Tyr Gln Ile Cys Val Ile Ala Asn Asn Ser Val 
            500                 505                 510         


Gly Ala Ser Pro Ala Ser Val Ile Val Ile Ser Ala Asp Pro Glu Asn 
        515                 520                 525             


Lys Glu Val Glu Glu Glu Arg Ile Ala Gly Thr Glu Gly Gly Phe Ser 
    530                 535                 540                 


Leu Ser Trp Lys Pro Gln Pro Gly Asp Val Ile Gly Tyr Val Val Asp 
545                 550                 555                 560 


Trp Cys Asp His Thr Gln Asp Val Leu Gly Asp Phe Gln Trp Lys Asn 
                565                 570                 575     


Val Gly Pro Asn Thr Thr Ser Thr Val Ile Ser Thr Asp Ala Phe Arg 
            580                 585                 590         


Pro Gly Val Arg Tyr Asp Phe Arg Ile Tyr Gly Leu Ser Thr Lys Arg 
        595                 600                 605             


Ile Ala Cys Leu Leu Glu Lys Lys Thr Gly Tyr Ser Gln Glu Leu Ala 
    610                 615                 620                 


Pro Ser Asp Asn Pro His Val Leu Val Asp Thr Leu Thr Ser His Ser 
625                 630                 635                 640 


Phe Thr Leu Ser Trp Lys Asp Tyr Ser Thr Glu Ser Gln Pro Gly Phe 
                645                 650                 655     


Ile Gln Gly Tyr His Val Tyr Leu Lys Ser Lys Ala Arg Gln Cys His 
            660                 665                 670         


Pro Arg Phe Glu Lys Ala Val Leu Ser Asp Gly Ser Glu Cys Cys Lys 
        675                 680                 685             


Tyr Lys Ile Asp Asn Pro Glu Glu Lys Ala Leu Ile Val Asp Asn Leu 
    690                 695                 700                 


Lys Pro Glu Ser Phe Tyr Glu Phe Phe Ile Thr Pro Phe Thr Ser Ala 
705                 710                 715                 720 


Gly Glu Gly Pro Ser Ala Thr Phe Thr Lys Val Thr Thr Pro Asp Glu 
                725                 730                 735     


His Ser Ser Met Leu Ile His Ile Leu Leu Pro Met Val Phe Cys Val 
            740                 745                 750         


Leu Leu Ile Met Val Met Cys Tyr Leu Lys Ser Gln Trp Ile Lys Glu 
        755                 760                 765             


Thr Cys Tyr Pro Asp Ile Pro Asp Pro Tyr Lys Ser Ser Ile Leu Ser 
    770                 775                 780                 


Leu Ile Lys Phe Lys Glu Asn Pro His Leu Ile Ile Met Asn Val Ser 
785                 790                 795                 800 


Asp Cys Ile Pro Asp Ala Ile Glu Val Val Ser Lys Pro Glu Gly Thr 
                805                 810                 815     


Lys Ile Gln Phe Leu Gly Thr Arg Lys Ser Leu Thr Glu Thr Glu Leu 
            820                 825                 830         


Thr Lys Pro Asn Tyr Leu Tyr Leu Leu Pro Thr Glu Lys Asn His Ser 
        835                 840                 845             


Gly Pro Gly Pro Cys Ile Cys Phe Glu Asn Leu Thr Tyr Asn Gln Ala 
    850                 855                 860                 


Ala Ser Asp Ser Gly Ser Cys Gly His Val Pro Val Ser Pro Lys Ala 
865                 870                 875                 880 


Pro Ser Met Leu Gly Leu Met Thr Ser Pro Glu Asn Val Leu Lys Ala 
                885                 890                 895     


Leu Glu Lys Asn Tyr Met Asn Ser Leu Gly Glu Ile Pro Ala Gly Glu 
            900                 905                 910         


Thr Ser Leu Asn Tyr Val Ser Gln Leu Ala Ser Pro Met Phe Gly Asp 
        915                 920                 925             


Lys Asp Ser Leu Pro Thr Asn Pro Val Glu Ala Pro His Cys Ser Glu 
    930                 935                 940                 


Tyr Lys Met Gln Met Ala Val Ser Leu Arg Leu Ala Leu Pro Pro Pro 
945                 950                 955                 960 


Thr Glu Asn Ser Ser Leu Ser Ser Ile Thr Leu Leu Asp Pro Gly Glu 
                965                 970                 975     


His Tyr Cys 
            


<210>  107
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Ala Leu Phe Ala Val Phe Gln Thr Thr Phe Phe Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Thr Tyr Gln Ser Glu Val Leu Ala Glu Arg Leu Pro Leu 
            20                  25                  30          


Thr Pro Val Ser Leu Lys Val Ser Thr Asn Ser Thr Arg Gln Ser Leu 
        35                  40                  45              


His Leu Gln Trp Thr Val His Asn Leu Pro Tyr His Gln Glu Leu Lys 
    50                  55                  60                  


Met Val Phe Gln Ile Gln Ile Ser Arg Ile Glu Thr Ser Asn Val Ile 
65                  70                  75                  80  


Trp Val Gly Asn Tyr Ser Thr Thr Val Lys Trp Asn Gln Val Leu His 
                85                  90                  95      


Trp Ser Trp Glu Ser Glu Leu Pro Leu Glu Cys Ala Thr His Phe Val 
            100                 105                 110         


Arg Ile Lys Ser Leu Val Asp Asp Ala Lys Phe Pro Glu Pro Asn Phe 
        115                 120                 125             


Trp Ser Asn Trp Ser Ser Trp Glu Glu Val Ser Val Gln Asp Ser Thr 
    130                 135                 140                 


Gly Gln Asp Ile Leu Phe Val Phe Pro Lys Asp Lys Leu Val Glu Glu 
145                 150                 155                 160 


Gly Thr Asn Val Thr Ile Cys Tyr Val Ser Arg Asn Ile Gln Asn Asn 
                165                 170                 175     


Val Ser Cys Tyr Leu Glu Gly Lys Gln Ile His Gly Glu Gln Leu Asp 
            180                 185                 190         


Pro His Val Thr Ala Phe Asn Leu Asn Ser Val Pro Phe Ile Arg Asn 
        195                 200                 205             


Lys Gly Thr Asn Ile Tyr Cys Glu Ala Ser Gln Gly Asn Val Ser Glu 
    210                 215                 220                 


Gly Met Lys Gly Ile Val Leu Phe Val Ser Lys Val Leu Glu Glu Pro 
225                 230                 235                 240 


Lys Asp Phe Ser Cys Glu Thr Glu Asp Phe Lys Thr Leu His Cys Thr 
                245                 250                 255     


Trp Asp Pro Gly Thr Asp Thr Ala Leu Gly Trp Ser Lys Gln Pro Ser 
            260                 265                 270         


Gln Ser Tyr Thr Leu Phe Glu Ser Phe Ser Gly Glu Lys Lys Leu Cys 
        275                 280                 285             


Thr His Lys Asn Trp Cys Asn Trp Gln Ile Thr Gln Asp Ser Gln Glu 
    290                 295                 300                 


Thr Tyr Asn Phe Thr Leu Ile Ala Glu Asn Tyr Leu Arg Lys Arg Ser 
305                 310                 315                 320 


Val Asn Ile Leu Phe Asn Leu Thr His Arg Gly Glu Thr Arg Val Val 
                325                 330                 335     


Thr Ala His Arg Gly His 
            340         


<210>  108
<211>  1573
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Arg Val Leu Ala Cys Leu Leu Ala Ala Leu Val Gly Ile Gln Ala 
1               5                   10                  15      


Val Glu Arg Leu Arg Leu Ala Asp Gly Pro His Gly Cys Ala Gly Arg 
            20                  25                  30          


Leu Glu Val Trp His Gly Gly Arg Trp Gly Thr Val Cys Asp Asp Gly 
        35                  40                  45              


Trp Asp Leu Arg Asp Ala Ala Val Ala Cys Arg Gln Leu Gly Cys Gly 
    50                  55                  60                  


Gly Ala Leu Ala Ala Pro Gly Gly Ala Phe Phe Gly Glu Gly Ala Gly 
65                  70                  75                  80  


Pro Val Trp Leu Ser Glu Leu Ala Cys Arg Gly Asn Glu Gly Gln Leu 
                85                  90                  95      


Gly Leu Cys His His Arg Gly Trp Lys Ala His Ile Cys Ser His Glu 
            100                 105                 110         


Glu Asp Ala Gly Val Val Cys Ala Gly Gln Arg Val Ala Asn Ser Arg 
        115                 120                 125             


Asp Asp Ser Thr Ser Pro Leu Asp Gly Ala Pro Trp Pro Gly Leu Leu 
    130                 135                 140                 


Leu Glu Leu Ser Pro Ser Thr Glu Glu Pro Leu Val Thr His Ala Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Asn Pro Gln Asn Ala Ser Arg Lys Lys Ser Pro Arg 
                165                 170                 175     


Pro Lys Gln Ala Lys Ser Thr Arg Ala Pro Leu Leu Thr Thr Gly Ala 
            180                 185                 190         


Pro Arg Gln Glu Arg Leu Arg Leu Val Ser Gly Pro His Arg Cys Ala 
        195                 200                 205             


Gly Arg Leu Glu Val Trp His Gly Gly Arg Trp Gly Thr Val Cys Asp 
    210                 215                 220                 


Asp Gly Trp Asp Leu Arg Asp Ala Ala Val Ala Cys Arg Glu Leu Gly 
225                 230                 235                 240 


Cys Gly Gly Ala Leu Ala Ala Pro Gly Gly Ala Arg Phe Gly Pro Gly 
                245                 250                 255     


Ala Gly Pro Val Trp Met Asp Asp Val Gly Cys Gly Gly Gly Glu Gln 
            260                 265                 270         


Ala Leu Arg Asp Cys Pro Arg Ser Pro Trp Gly Arg Ser Asn Cys Asp 
        275                 280                 285             


His Ser Glu Asp Ala Gly Leu Val Cys Thr Gly Pro Ala Pro Arg Leu 
    290                 295                 300                 


Arg Leu Ala Asp Gly Pro His Gly Cys Ala Gly Arg Leu Glu Val Trp 
305                 310                 315                 320 


His Gly Gly Arg Trp Gly Ser Val Cys Asp Asp Ala Trp Asp Leu Arg 
                325                 330                 335     


Asp Ala Ala Val Ala Cys Arg Glu Leu Gly Cys Gly Gly Ala Leu Ala 
            340                 345                 350         


Ala Pro Gly Gly Ala Phe Phe Gly Glu Gly Ser Gly Pro Ile Ile Leu 
        355                 360                 365             


Asp Asp Leu Arg Cys Arg Gly Asn Glu Thr Ala Leu Arg Phe Cys Pro 
    370                 375                 380                 


Ala Arg Pro Trp Gly Gln His Asp Cys His His Arg Glu Asp Ala Gly 
385                 390                 395                 400 


Ala Val Cys Asp Gly Met Pro Leu Gly Tyr Val Pro Pro Thr Ala Pro 
                405                 410                 415     


Thr Asp Ser Asn Asn Ser Thr Pro Arg Glu Ala Ala Ser Arg Pro Pro 
            420                 425                 430         


Ser Thr Met Thr Ser Gln Ala Pro Gly Thr Ala Gly Val Ser Pro Pro 
        435                 440                 445             


Pro Ala Ser Pro Thr Val Leu Trp Glu Pro Gly Pro Glu Ala Gly Ser 
    450                 455                 460                 


Pro Gln Leu Arg Leu Val Ala Gly Pro Ser Lys Cys Ser Gly Arg Leu 
465                 470                 475                 480 


Glu Val Trp His Asp Gln Arg Trp Gly Thr Val Cys Asp Asp Ser Trp 
                485                 490                 495     


Asp Met Arg Asp Ser Ala Val Val Cys Arg Glu Leu Gly Cys Gly Gly 
            500                 505                 510         


Pro Gln Gln Pro Asp Pro Ala Ala Gly Arg Phe Gly Trp Gly Ala Gly 
        515                 520                 525             


Pro Ile Trp Leu Asp Asp Val Gly Cys Val Gly Thr Glu Ala Ser Leu 
    530                 535                 540                 


Ser Asp Cys Pro Ala Ala Pro Trp Gly Lys His Asn Cys Ala His Asn 
545                 550                 555                 560 


Glu Asp Val Gly Val Thr Cys Thr Gly Pro Pro Gly Leu Asp Ser Ile 
                565                 570                 575     


Ser Asp Pro Phe Ser Trp Ser Trp Ile Pro Gly Leu Gly Arg Asp Arg 
            580                 585                 590         


Asp Ala Trp Leu Pro Gly Glu Leu Ala Thr Lys Pro Ser Ala Ser Val 
        595                 600                 605             


Thr Ala Ser Val Leu Glu Lys Thr Thr Thr Lys Ala Pro Gly Lys Met 
    610                 615                 620                 


Pro Lys Ser Thr Lys Lys Trp Val Thr Lys Asn Ala Lys Arg Pro Thr 
625                 630                 635                 640 


Thr Gln Pro Pro Val Met Pro Thr Thr Lys His Ser Arg Ala Gln Ser 
                645                 650                 655     


Pro Pro Asp Leu Thr Ser Gln Thr Thr Ala Ala Leu Thr Thr Glu Ala 
            660                 665                 670         


Ser Arg Arg Pro Thr Ser Glu Phe Thr Arg Arg Pro Thr Thr Glu Ala 
        675                 680                 685             


Pro Gln Arg Trp Thr Ser His Thr Thr Ala Thr Leu Thr Pro Gln Ala 
    690                 695                 700                 


Pro Arg Glu Arg Thr Thr Lys Thr Met Ala Met Leu Thr Thr Gln Gly 
705                 710                 715                 720 


Pro Gln Glu Met Thr Ser Glu Ser Thr Ile Lys Ser Ile Pro Gln Ala 
                725                 730                 735     


Ser Leu Glu Pro Ser Ala Glu Ile Pro Glu Gly Ser Pro Glu Ser Pro 
            740                 745                 750         


Lys Asp Pro Ala Pro Ser Pro Ser Val Ser Thr Thr Gly Glu Ser Gly 
        755                 760                 765             


Leu Phe Arg Val Arg Leu Ala Asp Gly Pro Asn Arg Cys Ala Gly Arg 
    770                 775                 780                 


Leu Glu Val Trp His Ala Gly Arg Trp Gly Thr Val Cys Asp Asp Asn 
785                 790                 795                 800 


Trp Asp Leu Arg Asp Ala Thr Val Ala Cys Trp Glu Leu Gly Cys Gly 
                805                 810                 815     


Lys Val Arg Pro Arg Val Gly Lys Thr His Tyr Gly Pro Gly Thr Gly 
            820                 825                 830         


Pro Ile Trp Leu Asp Asp Met Gly Cys Lys Gly Ser Glu Ala Ser Leu 
        835                 840                 845             


Ser Asp Cys Pro Ser Gly Ala Trp Gly Lys His Asn Cys Asp His Glu 
    850                 855                 860                 


Glu Asp Val Gly Leu Thr Cys Thr Gly Tyr Thr Asp Tyr Asp Asp Tyr 
865                 870                 875                 880 


Pro Pro Trp Thr Trp Asp Pro Thr Ser Arg Glu Asp Leu Ala Lys Gly 
                885                 890                 895     


Thr Thr Thr Ala Gly Val Pro Gly His Thr Leu Pro Trp Arg Thr Thr 
            900                 905                 910         


Arg Arg Pro Gly Ser Ser Ser Pro Ala Ile Arg Arg Leu Pro Asp Thr 
        915                 920                 925             


Gly Ser Lys Asp Gly Tyr Lys Leu Pro Trp Thr Trp Asp Thr Pro Ser 
    930                 935                 940                 


Gly Arg Gly Leu Ala Glu Gly Thr Pro Thr Ala Gly Lys Leu Gly Pro 
945                 950                 955                 960 


Thr Leu Gly Ala Gly Thr Thr Arg Ser Pro Gly Ser Pro Pro Thr Leu 
                965                 970                 975     


Arg Val His Gly Asp Thr Gly Ser Pro Arg Lys Pro Trp Pro Glu Arg 
            980                 985                 990         


Arg Pro Pro Arg Pro Ala Ala Thr  Arg Thr Ala Pro Pro  Thr Pro Ser 
        995                 1000                 1005             


Pro Gly  Pro Ser Ala Ser Pro  Gly Pro Pro Gly Pro  Ala Leu Thr 
    1010                 1015                 1020             


Ser Asp  Ser Ser Arg Glu Leu  Thr Pro His Ser Ala  Leu Thr Ser 
    1025                 1030                 1035             


Glu Ala  Thr Ser Asp Ala Pro  Asp Thr Ser Pro Pro  Thr Pro Asp 
    1040                 1045                 1050             


Pro Ala  Ser Arg Thr Asn Pro  Asp Leu Ile Leu Thr  Ser Pro Asp 
    1055                 1060                 1065             


Phe Ala  Leu Ser Thr Pro Asp  Ser Ser Val Val Pro  Ala Leu Thr 
    1070                 1075                 1080             


Pro Glu  Pro Ser Pro Thr Pro  Leu Pro Thr Leu Pro  Lys Glu Leu 
    1085                 1090                 1095             


Thr Ser  Asp Pro Ser Thr Pro  Ser Glu Val Thr Ser  Leu Ser Pro 
    1100                 1105                 1110             


Thr Ser  Glu Gln Val Pro Glu  Ser Asp Thr Thr Pro  Asp Leu Asp 
    1115                 1120                 1125             


Thr Thr  Pro Tyr Ser Ser Thr  Val Ser Glu Tyr Ser  Arg Ser Pro 
    1130                 1135                 1140             


Asp Pro  Ser Pro Ser Pro His  Pro Thr Thr Thr Pro  Asp Pro Thr 
    1145                 1150                 1155             


Met Ala  Pro Asp Pro Ile Thr  Thr Leu Asn Pro Thr  Val Thr Pro 
    1160                 1165                 1170             


His Phe  Pro Thr Thr Pro His  Pro Thr Thr Thr Pro  His Pro Thr 
    1175                 1180                 1185             


Thr Ile  Thr His Ser Thr Met  Ile Pro Asp Pro Thr  Thr Thr Pro 
    1190                 1195                 1200             


Gln Pro  Phe Thr Thr Ile Thr  His Ser Thr Met Ile  Pro Asp Pro 
    1205                 1210                 1215             


Thr Thr  Thr Pro Gln Pro Phe  Thr Thr Met Gln Pro  Thr Thr Thr 
    1220                 1225                 1230             


Pro His  Ser Thr Thr Pro His  Pro Thr Thr Thr Pro  His Pro Thr 
    1235                 1240                 1245             


Thr Ile  Thr His Ser Thr Met  Ile Pro Asp Pro Thr  Thr Thr Pro 
    1250                 1255                 1260             


Gln Pro  Phe Thr Thr Met Gln  Pro Thr Thr Met Pro  His Pro Thr 
    1265                 1270                 1275             


Thr Thr  Pro His Pro Thr Thr  Thr Pro His Pro Thr  Thr Thr Pro 
    1280                 1285                 1290             


His Pro  Thr Thr Thr Pro His  Pro Thr Met Thr Pro  Asp Pro Thr 
    1295                 1300                 1305             


Thr Thr  Pro Tyr Pro Thr Thr  Thr Pro Asp Pro Thr  Thr Thr Pro 
    1310                 1315                 1320             


His Pro  Thr Thr Pro Asp Pro  Ser Ser Thr Pro Val  Ile Thr Thr 
    1325                 1330                 1335             


Val Ser  Leu Pro Thr Ser Leu  Gly Thr Glu Leu Ser  Ser Pro Thr 
    1340                 1345                 1350             


Leu Ala  Pro Thr Val Lys Pro  Ser Leu His Pro Gln  Leu Thr Phe 
    1355                 1360                 1365             


Thr Ala  Pro Ala Pro His Thr  Ser Thr Ser Gln Ile  Pro Thr Leu 
    1370                 1375                 1380             


Glu Pro  Ser Pro Ala Leu Glu  Ser Ser Pro Ser Arg  Ser Ser Thr 
    1385                 1390                 1395             


Ala Thr  Ser Met Asp Pro Leu  Ser Thr Glu Asp Phe  Lys Pro Pro 
    1400                 1405                 1410             


Arg Ser  Gln Ser Pro Asn Leu  Thr Pro Pro Pro Thr  His Thr Pro 
    1415                 1420                 1425             


His Ser  Ala Ser Asp Leu Thr  Val Ser Pro Asp Pro  Leu Leu Ser 
    1430                 1435                 1440             


Pro Thr  Ala His Pro Leu Asp  His Pro Pro Leu Asp  Pro Leu Thr 
    1445                 1450                 1455             


Leu Gly  Pro Thr Pro Gly Gln  Ser Pro Gly Pro His  Gly Pro Cys 
    1460                 1465                 1470             


Val Ala  Pro Thr Pro Pro Val  Arg Val Met Ala Cys  Glu Pro Pro 
    1475                 1480                 1485             


Ala Leu  Val Glu Leu Val Ala  Ala Val Arg Asp Val  Gly Gly Gln 
    1490                 1495                 1500             


Leu Gln  Arg Leu Thr Gln Val  Val Glu Gln Glu Arg  Gln Glu Arg 
    1505                 1510                 1515             


Gln Ala  Leu Leu Leu Gly Leu  Thr Gln Leu Val Glu  Ala Ala Arg 
    1520                 1525                 1530             


Gly Leu  Gly Gln Leu Gly Glu  Ala Val Lys Arg Leu  Ala Glu Met 
    1535                 1540                 1545             


Ala Trp  Thr Thr Ser Met Pro  Ala Pro Thr Thr Thr  Thr Pro Glu 
    1550                 1555                 1560             


Glu Glu  Glu Arg Pro Leu Arg  Gly Asp Val 
    1565                 1570             


<210>  109
<211>  951
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Arg Val Leu Ala Cys Leu Leu Ala Ala Leu Val Gly Ile Gln Ala 
1               5                   10                  15      


Val Glu Arg Leu Arg Leu Ala Asp Gly Pro His Gly Cys Ala Gly Arg 
            20                  25                  30          


Leu Glu Val Trp His Gly Gly Arg Trp Gly Thr Val Cys Asp Asp Gly 
        35                  40                  45              


Trp Asp Leu Arg Asp Ala Ala Val Ala Cys Arg Gln Leu Gly Cys Gly 
    50                  55                  60                  


Gly Ala Leu Ala Ala Pro Gly Gly Ala Phe Phe Gly Glu Gly Ala Gly 
65                  70                  75                  80  


Pro Val Trp Leu Ser Glu Leu Ala Cys Arg Gly Asn Glu Gly Gln Leu 
                85                  90                  95      


Gly Leu Cys His His Arg Gly Trp Lys Ala His Ile Cys Ser His Glu 
            100                 105                 110         


Glu Asp Ala Gly Val Val Cys Ala Gly Gln Arg Val Ala Asn Ser Arg 
        115                 120                 125             


Asp Asp Ser Thr Ser Pro Leu Asp Gly Ala Pro Trp Pro Gly Leu Leu 
    130                 135                 140                 


Leu Glu Leu Ser Pro Ser Thr Glu Glu Pro Leu Val Thr His Ala Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Asn Pro Gln Asn Ala Ser Arg Lys Lys Ser Pro Arg 
                165                 170                 175     


Pro Lys Gln Ala Lys Ser Thr Arg Ala Pro Leu Leu Thr Thr Gly Ala 
            180                 185                 190         


Pro Arg Gln Glu Arg Leu Arg Leu Val Ser Gly Pro His Arg Cys Ala 
        195                 200                 205             


Gly Arg Leu Glu Val Trp His Gly Gly Arg Trp Gly Thr Val Cys Asp 
    210                 215                 220                 


Asp Gly Trp Asp Leu Arg Asp Ala Ala Val Ala Cys Arg Glu Leu Gly 
225                 230                 235                 240 


Cys Gly Gly Ala Leu Ala Ala Pro Gly Gly Ala Arg Phe Gly Pro Gly 
                245                 250                 255     


Ala Gly Pro Val Trp Met Asp Asp Val Gly Cys Gly Gly Gly Glu Gln 
            260                 265                 270         


Ala Leu Arg Asp Cys Pro Arg Ser Pro Trp Gly Arg Ser Asn Cys Asp 
        275                 280                 285             


His Ser Glu Asp Ala Gly Leu Val Cys Thr Gly Pro Ala Pro Arg Leu 
    290                 295                 300                 


Arg Leu Ala Asp Gly Pro His Gly Cys Ala Gly Arg Leu Glu Val Trp 
305                 310                 315                 320 


His Gly Gly Arg Trp Gly Ser Val Cys Asp Asp Ala Trp Asp Leu Arg 
                325                 330                 335     


Asp Ala Ala Val Ala Cys Arg Glu Leu Gly Cys Gly Gly Ala Leu Ala 
            340                 345                 350         


Ala Pro Gly Gly Ala Phe Phe Gly Glu Gly Ser Gly Pro Ile Ile Leu 
        355                 360                 365             


Asp Asp Leu Arg Cys Arg Gly Asn Glu Thr Ala Leu Arg Phe Cys Pro 
    370                 375                 380                 


Ala Arg Pro Trp Gly Gln His Asp Cys His His Arg Glu Asp Ala Gly 
385                 390                 395                 400 


Ala Val Cys Asp Gly Met Pro Leu Gly Tyr Val Pro Pro Thr Ala Pro 
                405                 410                 415     


Thr Asp Ser Asn Asn Ser Thr Pro Arg Glu Ala Ala Ser Arg Pro Pro 
            420                 425                 430         


Ser Thr Met Thr Ser Gln Ala Pro Gly Thr Ala Gly Val Ser Pro Pro 
        435                 440                 445             


Pro Ala Ser Pro Thr Val Leu Trp Glu Pro Gly Pro Glu Ala Gly Ser 
    450                 455                 460                 


Pro Gln Leu Arg Leu Val Ala Gly Pro Ser Lys Cys Ser Gly Arg Leu 
465                 470                 475                 480 


Glu Val Trp His Asp Gln Arg Trp Gly Thr Val Cys Asp Asp Ser Trp 
                485                 490                 495     


Asp Met Arg Asp Ser Ala Val Val Cys Arg Glu Leu Gly Cys Gly Gly 
            500                 505                 510         


Pro Gln Gln Pro Asp Pro Ala Ala Gly Arg Phe Gly Trp Gly Ala Gly 
        515                 520                 525             


Pro Ile Trp Leu Asp Asp Val Gly Cys Val Gly Thr Glu Ala Ser Leu 
    530                 535                 540                 


Ser Asp Cys Pro Ala Ala Pro Trp Gly Lys His Asn Cys Ala His Asn 
545                 550                 555                 560 


Glu Asp Val Gly Val Thr Cys Thr Gly Pro Pro Gly Leu Asp Ser Ile 
                565                 570                 575     


Ser Asp Pro Phe Ser Trp Ser Trp Ile Pro Gly Leu Gly Arg Asp Arg 
            580                 585                 590         


Asp Ala Trp Leu Pro Gly Glu Leu Ala Thr Lys Pro Ser Ala Ser Val 
        595                 600                 605             


Thr Ala Ser Val Leu Glu Lys Thr Thr Thr Lys Ala Pro Gly Lys Met 
    610                 615                 620                 


Pro Lys Ser Thr Lys Lys Trp Val Thr Lys Asn Ala Lys Arg Pro Thr 
625                 630                 635                 640 


Thr Gln Pro Pro Val Met Pro Thr Thr Lys His Ser Arg Ala Gln Ser 
                645                 650                 655     


Pro Pro Asp Leu Thr Ser Gln Thr Thr Ala Ala Leu Thr Thr Glu Ala 
            660                 665                 670         


Ser Arg Arg Pro Thr Ser Glu Phe Thr Arg Arg Pro Thr Thr Glu Ala 
        675                 680                 685             


Pro Gln Arg Trp Thr Ser His Thr Thr Ala Thr Leu Thr Pro Gln Ala 
    690                 695                 700                 


Pro Arg Glu Arg Thr Thr Lys Thr Met Ala Met Leu Thr Thr Gln Gly 
705                 710                 715                 720 


Pro Gln Glu Met Thr Ser Glu Ser Thr Ile Lys Ser Ile Pro Gln Ala 
                725                 730                 735     


Ser Leu Glu Pro Ser Ala Glu Ile Pro Glu Gly Ser Pro Glu Ser Pro 
            740                 745                 750         


Lys Asp Pro Ala Pro Ser Pro Ser Val Ser Thr Thr Gly Glu Ser Gly 
        755                 760                 765             


Leu Phe Arg Val Arg Leu Ala Asp Gly Pro Asn Arg Cys Ala Gly Arg 
    770                 775                 780                 


Leu Glu Val Trp His Ala Gly Arg Trp Gly Thr Val Cys Asp Asp Asn 
785                 790                 795                 800 


Trp Asp Leu Arg Asp Ala Thr Val Ala Cys Trp Glu Leu Gly Cys Gly 
                805                 810                 815     


Lys Val Arg Pro Arg Val Gly Lys Thr His Tyr Gly Pro Gly Thr Gly 
            820                 825                 830         


Pro Ile Trp Leu Asp Asp Met Gly Cys Lys Gly Ser Glu Ala Ser Leu 
        835                 840                 845             


Ser Asp Cys Pro Ser Gly Ala Trp Gly Lys His Asn Cys Asp His Glu 
    850                 855                 860                 


Glu Asp Val Gly Leu Thr Cys Thr Gly Tyr Thr Asp Tyr Asp Asp Tyr 
865                 870                 875                 880 


Pro Pro Trp Thr Trp Asp Pro Thr Ser Arg Glu Asp Leu Ala Lys Gly 
                885                 890                 895     


Thr Thr Thr Ala Gly Val Pro Gly His Thr Leu Pro Trp Arg Thr Thr 
            900                 905                 910         


Arg Arg Pro Gly Ser Ser Ser Pro Ala Ile Arg Arg Leu Pro Asp Thr 
        915                 920                 925             


Glu Pro Glu Ala Gly Ala Pro Arg Gly Asp Ala Pro Arg Ser Arg Thr 
    930                 935                 940                 


Ala Arg Val Ala Ala Pro Pro 
945                 950     


<210>  110
<211>  4244
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Met Pro Ala Gln Tyr Ala Leu Thr Ser Ser Leu Val Leu Leu Val 
1               5                   10                  15      


Leu Leu Ser Thr Ala Arg Ala Gly Pro Phe Ser Ser Arg Ser Asn Val 
            20                  25                  30          


Thr Leu Pro Ala Pro Arg Pro Pro Pro Gln Pro Gly Gly His Thr Val 
        35                  40                  45              


Gly Ala Gly Val Gly Ser Pro Ser Ser Gln Leu Tyr Glu His Thr Val 
    50                  55                  60                  


Glu Gly Gly Glu Lys Gln Val Val Phe Thr His Arg Ile Asn Leu Pro 
65                  70                  75                  80  


Pro Ser Thr Gly Cys Gly Cys Pro Pro Gly Thr Glu Pro Pro Val Leu 
                85                  90                  95      


Ala Ser Glu Val Gln Ala Leu Arg Val Arg Leu Glu Ile Leu Glu Glu 
            100                 105                 110         


Leu Val Lys Gly Leu Lys Glu Gln Cys Thr Gly Gly Cys Cys Pro Ala 
        115                 120                 125             


Ser Ala Gln Ala Gly Thr Gly Gln Thr Asp Val Arg Thr Leu Cys Ser 
    130                 135                 140                 


Leu His Gly Val Phe Asp Leu Ser Arg Cys Thr Cys Ser Cys Glu Pro 
145                 150                 155                 160 


Gly Trp Gly Gly Pro Thr Cys Ser Asp Pro Thr Asp Ala Glu Ile Pro 
                165                 170                 175     


Pro Ser Ser Pro Pro Ser Ala Ser Gly Ser Cys Pro Asp Asp Cys Asn 
            180                 185                 190         


Asp Gln Gly Arg Cys Val Arg Gly Arg Cys Val Cys Phe Pro Gly Tyr 
        195                 200                 205             


Thr Gly Pro Ser Cys Gly Trp Pro Ser Cys Pro Gly Asp Cys Gln Gly 
    210                 215                 220                 


Arg Gly Arg Cys Val Gln Gly Val Cys Val Cys Arg Ala Gly Phe Ser 
225                 230                 235                 240 


Gly Pro Asp Cys Ser Gln Arg Ser Cys Pro Arg Gly Cys Ser Gln Arg 
                245                 250                 255     


Gly Arg Cys Glu Gly Gly Arg Cys Val Cys Asp Pro Gly Tyr Thr Gly 
            260                 265                 270         


Asp Asp Cys Gly Met Arg Ser Cys Pro Arg Gly Cys Ser Gln Arg Gly 
        275                 280                 285             


Arg Cys Glu Asn Gly Arg Cys Val Cys Asn Pro Gly Tyr Thr Gly Glu 
    290                 295                 300                 


Asp Cys Gly Val Arg Ser Cys Pro Arg Gly Cys Ser Gln Arg Gly Arg 
305                 310                 315                 320 


Cys Lys Asp Gly Arg Cys Val Cys Asp Pro Gly Tyr Thr Gly Glu Asp 
                325                 330                 335     


Cys Gly Thr Arg Ser Cys Pro Trp Asp Cys Gly Glu Gly Gly Arg Cys 
            340                 345                 350         


Val Asp Gly Arg Cys Val Cys Trp Pro Gly Tyr Thr Gly Glu Asp Cys 
        355                 360                 365             


Ser Thr Arg Thr Cys Pro Arg Asp Cys Arg Gly Arg Gly Arg Cys Glu 
    370                 375                 380                 


Asp Gly Glu Cys Ile Cys Asp Thr Gly Tyr Ser Gly Asp Asp Cys Gly 
385                 390                 395                 400 


Val Arg Ser Cys Pro Gly Asp Cys Asn Gln Arg Gly Arg Cys Glu Asp 
                405                 410                 415     


Gly Arg Cys Val Cys Trp Pro Gly Tyr Thr Gly Thr Asp Cys Gly Ser 
            420                 425                 430         


Arg Ala Cys Pro Arg Asp Cys Arg Gly Arg Gly Arg Cys Glu Asn Gly 
        435                 440                 445             


Val Cys Val Cys Asn Ala Gly Tyr Ser Gly Glu Asp Cys Gly Val Arg 
    450                 455                 460                 


Ser Cys Pro Gly Asp Cys Arg Gly Arg Gly Arg Cys Glu Ser Gly Arg 
465                 470                 475                 480 


Cys Met Cys Trp Pro Gly Tyr Thr Gly Arg Asp Cys Gly Thr Arg Ala 
                485                 490                 495     


Cys Pro Gly Asp Cys Arg Gly Arg Gly Arg Cys Val Asp Gly Arg Cys 
            500                 505                 510         


Val Cys Asn Pro Gly Phe Thr Gly Glu Asp Cys Gly Ser Arg Arg Cys 
        515                 520                 525             


Pro Gly Asp Cys Arg Gly His Gly Leu Cys Glu Asp Gly Val Cys Val 
    530                 535                 540                 


Cys Asp Ala Gly Tyr Ser Gly Glu Asp Cys Ser Thr Arg Ser Cys Pro 
545                 550                 555                 560 


Gly Gly Cys Arg Gly Arg Gly Gln Cys Leu Asp Gly Arg Cys Val Cys 
                565                 570                 575     


Glu Asp Gly Tyr Ser Gly Glu Asp Cys Gly Val Arg Gln Cys Pro Asn 
            580                 585                 590         


Asp Cys Ser Gln His Gly Val Cys Gln Asp Gly Val Cys Ile Cys Trp 
        595                 600                 605             


Glu Gly Tyr Val Ser Glu Asp Cys Ser Ile Arg Thr Cys Pro Ser Asn 
    610                 615                 620                 


Cys His Gly Arg Gly Arg Cys Glu Glu Gly Arg Cys Leu Cys Asp Pro 
625                 630                 635                 640 


Gly Tyr Thr Gly Pro Thr Cys Ala Thr Arg Met Cys Pro Ala Asp Cys 
                645                 650                 655     


Arg Gly Arg Gly Arg Cys Val Gln Gly Val Cys Leu Cys His Val Gly 
            660                 665                 670         


Tyr Gly Gly Glu Asp Cys Gly Gln Glu Glu Pro Pro Ala Ser Ala Cys 
        675                 680                 685             


Pro Gly Gly Cys Gly Pro Arg Glu Leu Cys Arg Ala Gly Gln Cys Val 
    690                 695                 700                 


Cys Val Glu Gly Phe Arg Gly Pro Asp Cys Ala Ile Gln Thr Cys Pro 
705                 710                 715                 720 


Gly Asp Cys Arg Gly Arg Gly Glu Cys His Asp Gly Ser Cys Val Cys 
                725                 730                 735     


Lys Asp Gly Tyr Ala Gly Glu Asp Cys Gly Glu Glu Val Pro Thr Ile 
            740                 745                 750         


Glu Gly Met Arg Met His Leu Leu Glu Glu Thr Thr Val Arg Thr Glu 
        755                 760                 765             


Trp Thr Pro Ala Pro Gly Pro Val Asp Ala Tyr Glu Ile Gln Phe Ile 
    770                 775                 780                 


Pro Thr Thr Glu Gly Ala Ser Pro Pro Phe Thr Ala Arg Val Pro Ser 
785                 790                 795                 800 


Ser Ala Ser Ala Tyr Asp Gln Arg Gly Leu Ala Pro Gly Gln Glu Tyr 
                805                 810                 815     


Gln Val Thr Val Arg Ala Leu Arg Gly Thr Ser Trp Gly Leu Pro Ala 
            820                 825                 830         


Ser Lys Thr Ile Thr Thr Met Ile Asp Gly Pro Gln Asp Leu Arg Val 
        835                 840                 845             


Val Ala Val Thr Pro Thr Thr Leu Glu Leu Gly Trp Leu Arg Pro Gln 
    850                 855                 860                 


Ala Glu Val Asp Arg Phe Val Val Ser Tyr Val Ser Ala Gly Asn Gln 
865                 870                 875                 880 


Arg Val Arg Leu Glu Val Pro Pro Glu Ala Asp Gly Thr Leu Leu Thr 
                885                 890                 895     


Asp Leu Met Pro Gly Val Glu Tyr Val Val Thr Val Thr Ala Glu Arg 
            900                 905                 910         


Gly Arg Ala Val Ser Tyr Pro Ala Ser Val Arg Ala Asn Thr Gly Ser 
        915                 920                 925             


Ser Pro Leu Gly Leu Leu Gly Thr Thr Asp Glu Pro Pro Pro Ser Gly 
    930                 935                 940                 


Pro Ser Thr Thr Gln Gly Ala Gln Ala Pro Leu Leu Gln Gln Arg Pro 
945                 950                 955                 960 


Gln Glu Leu Gly Glu Leu Arg Val Leu Gly Arg Asp Glu Thr Gly Arg 
                965                 970                 975     


Leu Arg Val Val Trp Thr Ala Gln Pro Asp Thr Phe Ala Tyr Phe Gln 
            980                 985                 990         


Leu Arg Met Arg Val Pro Glu Gly  Pro Gly Ala His Glu  Glu Val Leu 
        995                 1000                 1005             


Pro Gly  Asp Val Arg Gln Ala  Leu Val Pro Pro Pro  Pro Pro Gly 
    1010                 1015                 1020             


Thr Pro  Tyr Glu Leu Ser Leu  His Gly Val Pro Pro  Gly Gly Lys 
    1025                 1030                 1035             


Pro Ser  Asp Pro Ile Ile Tyr  Gln Gly Ile Met Asp  Lys Asp Glu 
    1040                 1045                 1050             


Glu Lys  Pro Gly Lys Ser Ser  Gly Pro Pro Arg Leu  Gly Glu Leu 
    1055                 1060                 1065             


Thr Val  Thr Asp Arg Thr Ser  Asp Ser Leu Leu Leu  Arg Trp Thr 
    1070                 1075                 1080             


Val Pro  Glu Gly Glu Phe Asp  Ser Phe Val Ile Gln  Tyr Lys Asp 
    1085                 1090                 1095             


Arg Asp  Gly Gln Pro Gln Val  Val Pro Val Glu Gly  Pro Gln Arg 
    1100                 1105                 1110             


Ser Ala  Val Ile Thr Ser Leu  Asp Pro Gly Arg Lys  Tyr Lys Phe 
    1115                 1120                 1125             


Val Leu  Tyr Gly Phe Val Gly  Lys Lys Arg His Gly  Pro Leu Val 
    1130                 1135                 1140             


Ala Glu  Ala Lys Ile Leu Pro  Gln Ser Asp Pro Ser  Pro Gly Thr 
    1145                 1150                 1155             


Pro Pro  His Leu Gly Asn Leu  Trp Val Thr Asp Pro  Thr Pro Asp 
    1160                 1165                 1170             


Ser Leu  His Leu Ser Trp Thr  Val Pro Glu Gly Gln  Phe Asp Thr 
    1175                 1180                 1185             


Phe Met  Val Gln Tyr Arg Asp  Arg Asp Gly Arg Pro  Gln Val Val 
    1190                 1195                 1200             


Pro Val  Glu Gly Pro Glu Arg  Ser Phe Val Val Ser  Ser Leu Asp 
    1205                 1210                 1215             


Pro Asp  His Lys Tyr Arg Phe  Thr Leu Phe Gly Ile  Ala Asn Lys 
    1220                 1225                 1230             


Lys Arg  Tyr Gly Pro Leu Thr  Ala Asp Gly Thr Thr  Ala Pro Glu 
    1235                 1240                 1245             


Arg Lys  Glu Glu Pro Pro Arg  Pro Glu Phe Leu Glu  Gln Pro Leu 
    1250                 1255                 1260             


Leu Gly  Glu Leu Thr Val Thr  Gly Val Thr Pro Asp  Ser Leu Arg 
    1265                 1270                 1275             


Leu Ser  Trp Thr Val Ala Gln  Gly Pro Phe Asp Ser  Phe Met Val 
    1280                 1285                 1290             


Gln Tyr  Lys Asp Ala Gln Gly  Gln Pro Gln Ala Val  Pro Val Ala 
    1295                 1300                 1305             


Gly Asp  Glu Asn Glu Val Thr  Val Pro Gly Leu Asp  Pro Asp Arg 
    1310                 1315                 1320             


Lys Tyr  Lys Met Asn Leu Tyr  Gly Leu Arg Gly Arg  Gln Arg Val 
    1325                 1330                 1335             


Gly Pro  Glu Ser Val Val Ala  Lys Thr Ala Pro Gln  Glu Asp Val 
    1340                 1345                 1350             


Asp Glu  Thr Pro Ser Pro Thr  Glu Leu Gly Thr Glu  Ala Pro Glu 
    1355                 1360                 1365             


Ser Pro  Glu Glu Pro Leu Leu  Gly Glu Leu Thr Val  Thr Gly Ser 
    1370                 1375                 1380             


Ser Pro  Asp Ser Leu Ser Leu  Phe Trp Thr Val Pro  Gln Gly Ser 
    1385                 1390                 1395             


Phe Asp  Ser Phe Thr Val Gln  Tyr Lys Asp Arg Asp  Gly Arg Pro 
    1400                 1405                 1410             


Arg Ala  Val Arg Val Gly Gly  Lys Glu Ser Glu Val  Thr Val Gly 
    1415                 1420                 1425             


Gly Leu  Glu Pro Gly His Lys  Tyr Lys Met His Leu  Tyr Gly Leu 
    1430                 1435                 1440             


His Glu  Gly Gln Arg Val Gly  Pro Val Ser Ala Val  Gly Val Thr 
    1445                 1450                 1455             


Ala Pro  Gln Gln Glu Glu Thr  Pro Pro Ala Thr Glu  Ser Pro Leu 
    1460                 1465                 1470             


Glu Pro  Arg Leu Gly Glu Leu  Thr Val Thr Asp Val  Thr Pro Asn 
    1475                 1480                 1485             


Ser Val  Gly Leu Ser Trp Thr  Val Pro Glu Gly Gln  Phe Asp Ser 
    1490                 1495                 1500             


Phe Ile  Val Gln Tyr Lys Asp  Lys Asp Gly Gln Pro  Gln Val Val 
    1505                 1510                 1515             


Pro Val  Ala Ala Asp Gln Arg  Glu Val Thr Val Tyr  Asn Leu Glu 
    1520                 1525                 1530             


Pro Glu  Arg Lys Tyr Lys Met  Asn Met Tyr Gly Leu  His Asp Gly 
    1535                 1540                 1545             


Gln Arg  Met Gly Pro Leu Ser  Val Val Ile Val Thr  Ala Pro Leu 
    1550                 1555                 1560             


Pro Pro  Ala Pro Ala Thr Glu  Ala Ser Lys Pro Pro  Leu Glu Pro 
    1565                 1570                 1575             


Arg Leu  Gly Glu Leu Thr Val  Thr Asp Ile Thr Pro  Asp Ser Val 
    1580                 1585                 1590             


Gly Leu  Ser Trp Thr Val Pro  Glu Gly Glu Phe Asp  Ser Phe Val 
    1595                 1600                 1605             


Val Gln  Tyr Lys Asp Arg Asp  Gly Gln Pro Gln Val  Val Pro Val 
    1610                 1615                 1620             


Ala Ala  Asp Gln Arg Glu Val  Thr Ile Pro Asp Leu  Glu Pro Ser 
    1625                 1630                 1635             


Arg Lys  Tyr Lys Phe Leu Leu  Phe Gly Ile Gln Asp  Gly Lys Arg 
    1640                 1645                 1650             


Arg Ser  Pro Val Ser Val Glu  Ala Lys Thr Val Ala  Arg Gly Asp 
    1655                 1660                 1665             


Ala Ser  Pro Gly Ala Pro Pro  Arg Leu Gly Glu Leu  Trp Val Thr 
    1670                 1675                 1680             


Asp Pro  Thr Pro Asp Ser Leu  Arg Leu Ser Trp Thr  Val Pro Glu 
    1685                 1690                 1695             


Gly Gln  Phe Asp Ser Phe Val  Val Gln Phe Lys Asp  Lys Asp Gly 
    1700                 1705                 1710             


Pro Gln  Val Val Pro Val Glu  Gly His Glu Arg Ser  Val Thr Val 
    1715                 1720                 1725             


Thr Pro  Leu Asp Ala Gly Arg  Lys Tyr Arg Phe Leu  Leu Tyr Gly 
    1730                 1735                 1740             


Leu Leu  Gly Lys Lys Arg His  Gly Pro Leu Thr Ala  Asp Gly Thr 
    1745                 1750                 1755             


Thr Glu  Ala Arg Ser Ala Met  Asp Asp Thr Gly Thr  Lys Arg Pro 
    1760                 1765                 1770             


Pro Lys  Pro Arg Leu Gly Glu  Glu Leu Gln Val Thr  Thr Val Thr 
    1775                 1780                 1785             


Gln Asn  Ser Val Gly Leu Ser  Trp Thr Val Pro Glu  Gly Gln Phe 
    1790                 1795                 1800             


Asp Ser  Phe Val Val Gln Tyr  Lys Asp Arg Asp Gly  Gln Pro Gln 
    1805                 1810                 1815             


Val Val  Pro Val Glu Gly Ser  Leu Arg Glu Val Ser  Val Pro Gly 
    1820                 1825                 1830             


Leu Asp  Pro Ala His Arg Tyr  Lys Leu Leu Leu Tyr  Gly Leu His 
    1835                 1840                 1845             


His Gly  Lys Arg Val Gly Pro  Ile Ser Ala Val Ala  Ile Thr Ala 
    1850                 1855                 1860             


Gly Arg  Glu Glu Thr Glu Thr  Glu Thr Thr Ala Pro  Thr Pro Pro 
    1865                 1870                 1875             


Ala Pro  Glu Pro His Leu Gly  Glu Leu Thr Val Glu  Glu Ala Thr 
    1880                 1885                 1890             


Ser His  Thr Leu His Leu Ser  Trp Met Val Thr Glu  Gly Glu Phe 
    1895                 1900                 1905             


Asp Ser  Phe Glu Ile Gln Tyr  Thr Asp Arg Asp Gly  Gln Leu Gln 
    1910                 1915                 1920             


Met Val  Arg Ile Gly Gly Asp  Arg Asn Asp Ile Thr  Leu Ser Gly 
    1925                 1930                 1935             


Leu Glu  Ser Asp His Arg Tyr  Leu Val Thr Leu Tyr  Gly Phe Ser 
    1940                 1945                 1950             


Asp Gly  Lys His Val Gly Pro  Val His Val Glu Ala  Leu Thr Val 
    1955                 1960                 1965             


Pro Glu  Glu Glu Lys Pro Ser  Glu Pro Pro Thr Ala  Thr Pro Glu 
    1970                 1975                 1980             


Pro Pro  Ile Lys Pro Arg Leu  Gly Glu Leu Thr Val  Thr Asp Ala 
    1985                 1990                 1995             


Thr Pro  Asp Ser Leu Ser Leu  Ser Trp Thr Val Pro  Glu Gly Gln 
    2000                 2005                 2010             


Phe Asp  His Phe Leu Val Gln  Tyr Arg Asn Gly Asp  Gly Gln Pro 
    2015                 2020                 2025             


Lys Ala  Val Arg Val Pro Gly  His Glu Glu Gly Val  Thr Ile Ser 
    2030                 2035                 2040             


Gly Leu  Glu Pro Asp His Lys  Tyr Lys Met Asn Leu  Tyr Gly Phe 
    2045                 2050                 2055             


His Gly  Gly Gln Arg Met Gly  Pro Val Ser Val Val  Gly Val Thr 
    2060                 2065                 2070             


Ala Ala  Glu Glu Glu Thr Pro  Ser Pro Thr Glu Pro  Ser Met Glu 
    2075                 2080                 2085             


Ala Pro  Glu Pro Ala Glu Glu  Pro Leu Leu Gly Glu  Leu Thr Val 
    2090                 2095                 2100             


Thr Gly  Ser Ser Pro Asp Ser  Leu Ser Leu Ser Trp  Thr Val Pro 
    2105                 2110                 2115             


Gln Gly  Arg Phe Asp Ser Phe  Thr Val Gln Tyr Lys  Asp Arg Asp 
    2120                 2125                 2130             


Gly Arg  Pro Gln Val Val Arg  Val Gly Gly Glu Glu  Ser Glu Val 
    2135                 2140                 2145             


Thr Val  Gly Gly Leu Glu Pro  Gly Arg Lys Tyr Lys  Met His Leu 
    2150                 2155                 2160             


Tyr Gly  Leu His Glu Gly Arg  Arg Val Gly Pro Val  Ser Ala Val 
    2165                 2170                 2175             


Gly Val  Thr Ala Pro Glu Glu  Glu Ser Pro Asp Ala  Pro Leu Ala 
    2180                 2185                 2190             


Lys Leu  Arg Leu Gly Gln Met  Thr Val Arg Asp Ile  Thr Ser Asp 
    2195                 2200                 2205             


Ser Leu  Ser Leu Ser Trp Thr  Val Pro Glu Gly Gln  Phe Asp His 
    2210                 2215                 2220             


Phe Leu  Val Gln Phe Lys Asn  Gly Asp Gly Gln Pro  Lys Ala Val 
    2225                 2230                 2235             


Arg Val  Pro Gly His Glu Asp  Gly Val Thr Ile Ser  Gly Leu Glu 
    2240                 2245                 2250             


Pro Asp  His Lys Tyr Lys Met  Asn Leu Tyr Gly Phe  His Gly Gly 
    2255                 2260                 2265             


Gln Arg  Val Gly Pro Val Ser  Ala Val Gly Leu Thr  Ala Pro Gly 
    2270                 2275                 2280             


Lys Asp  Glu Glu Met Ala Pro  Ala Ser Thr Glu Pro  Pro Thr Pro 
    2285                 2290                 2295             


Glu Pro  Pro Ile Lys Pro Arg  Leu Glu Glu Leu Thr  Val Thr Asp 
    2300                 2305                 2310             


Ala Thr  Pro Asp Ser Leu Ser  Leu Ser Trp Thr Val  Pro Glu Gly 
    2315                 2320                 2325             


Gln Phe  Asp His Phe Leu Val  Gln Tyr Lys Asn Gly  Asp Gly Gln 
    2330                 2335                 2340             


Pro Lys  Ala Thr Arg Val Pro  Gly His Glu Asp Arg  Val Thr Ile 
    2345                 2350                 2355             


Ser Gly  Leu Glu Pro Asp Asn  Lys Tyr Lys Met Asn  Leu Tyr Gly 
    2360                 2365                 2370             


Phe His  Gly Gly Gln Arg Val  Gly Pro Val Ser Ala  Ile Gly Val 
    2375                 2380                 2385             


Thr Ala  Ala Glu Glu Glu Thr  Pro Ser Pro Thr Glu  Pro Ser Met 
    2390                 2395                 2400             


Glu Ala  Pro Glu Pro Pro Glu  Glu Pro Leu Leu Gly  Glu Leu Thr 
    2405                 2410                 2415             


Val Thr  Gly Ser Ser Pro Asp  Ser Leu Ser Leu Ser  Trp Thr Val 
    2420                 2425                 2430             


Pro Gln  Gly Arg Phe Asp Ser  Phe Thr Val Gln Tyr  Lys Asp Arg 
    2435                 2440                 2445             


Asp Gly  Arg Pro Gln Val Val  Arg Val Gly Gly Glu  Glu Ser Glu 
    2450                 2455                 2460             


Val Thr  Val Gly Gly Leu Glu  Pro Gly Arg Lys Tyr  Lys Met His 
    2465                 2470                 2475             


Leu Tyr  Gly Leu His Glu Gly  Arg Arg Val Gly Pro  Val Ser Thr 
    2480                 2485                 2490             


Val Gly  Val Thr Ala Pro Gln  Glu Asp Val Asp Glu  Thr Pro Ser 
    2495                 2500                 2505             


Pro Thr  Glu Pro Gly Thr Glu  Ala Pro Gly Pro Pro  Glu Glu Pro 
    2510                 2515                 2520             


Leu Leu  Gly Glu Leu Thr Val  Thr Gly Ser Ser Pro  Asp Ser Leu 
    2525                 2530                 2535             


Ser Leu  Ser Trp Thr Val Pro  Gln Gly Arg Phe Asp  Ser Phe Thr 
    2540                 2545                 2550             


Val Gln  Tyr Lys Asp Arg Asp  Gly Arg Pro Gln Ala  Val Arg Val 
    2555                 2560                 2565             


Gly Gly  Gln Glu Ser Lys Val  Thr Val Arg Gly Leu  Glu Pro Gly 
    2570                 2575                 2580             


Arg Lys  Tyr Lys Met His Leu  Tyr Gly Leu His Glu  Gly Arg Arg 
    2585                 2590                 2595             


Leu Gly  Pro Val Ser Ala Val  Gly Val Thr Glu Asp  Glu Ala Glu 
    2600                 2605                 2610             


Thr Thr  Gln Ala Val Pro Thr  Met Thr Pro Glu Pro  Pro Ile Lys 
    2615                 2620                 2625             


Pro Arg  Leu Gly Glu Leu Thr  Met Thr Asp Ala Thr  Pro Asp Ser 
    2630                 2635                 2640             


Leu Ser  Leu Ser Trp Thr Val  Pro Glu Gly Gln Phe  Asp His Phe 
    2645                 2650                 2655             


Leu Val  Gln Tyr Arg Asn Gly  Asp Gly Gln Pro Lys  Ala Val Arg 
    2660                 2665                 2670             


Val Pro  Gly His Glu Asp Gly  Val Thr Ile Ser Gly  Leu Glu Pro 
    2675                 2680                 2685             


Asp His  Lys Tyr Lys Met Asn  Leu Tyr Gly Phe His  Gly Gly Gln 
    2690                 2695                 2700             


Arg Val  Gly Pro Ile Ser Val  Ile Gly Val Thr Ala  Ala Glu Glu 
    2705                 2710                 2715             


Glu Thr  Pro Ser Pro Thr Glu  Leu Ser Thr Glu Ala  Pro Glu Pro 
    2720                 2725                 2730             


Pro Glu  Glu Pro Leu Leu Gly  Glu Leu Thr Val Thr  Gly Ser Ser 
    2735                 2740                 2745             


Pro Asp  Ser Leu Ser Leu Ser  Trp Thr Ile Pro Gln  Gly His Phe 
    2750                 2755                 2760             


Asp Ser  Phe Thr Val Gln Tyr  Lys Asp Arg Asp Gly  Arg Pro Gln 
    2765                 2770                 2775             


Val Met  Arg Val Arg Gly Glu  Glu Ser Glu Val Thr  Val Gly Gly 
    2780                 2785                 2790             


Leu Glu  Pro Gly Arg Lys Tyr  Lys Met His Leu Tyr  Gly Leu His 
    2795                 2800                 2805             


Glu Gly  Arg Arg Val Gly Pro  Val Ser Thr Val Gly  Val Thr Ala 
    2810                 2815                 2820             


Pro Glu  Asp Glu Ala Glu Thr  Thr Gln Ala Val Pro  Thr Thr Thr 
    2825                 2830                 2835             


Pro Glu  Pro Pro Asn Lys Pro  Arg Leu Gly Glu Leu  Thr Val Thr 
    2840                 2845                 2850             


Asp Ala  Thr Pro Asp Ser Leu  Ser Leu Ser Trp Met  Val Pro Glu 
    2855                 2860                 2865             


Gly Gln  Phe Asp His Phe Leu  Val Gln Tyr Arg Asn  Gly Asp Gly 
    2870                 2875                 2880             


Gln Pro  Lys Val Val Arg Val  Pro Gly His Glu Asp  Gly Val Thr 
    2885                 2890                 2895             


Ile Ser  Gly Leu Glu Pro Asp  His Lys Tyr Lys Met  Asn Leu Tyr 
    2900                 2905                 2910             


Gly Phe  His Gly Gly Gln Arg  Val Gly Pro Ile Ser  Val Ile Gly 
    2915                 2920                 2925             


Val Thr  Ala Ala Glu Glu Glu  Thr Pro Ala Pro Thr  Glu Pro Ser 
    2930                 2935                 2940             


Thr Glu  Ala Pro Glu Pro Pro  Glu Glu Pro Leu Leu  Gly Glu Leu 
    2945                 2950                 2955             


Thr Val  Thr Gly Ser Ser Pro  Asp Ser Leu Ser Leu  Ser Trp Thr 
    2960                 2965                 2970             


Ile Pro  Gln Gly Arg Phe Asp  Ser Phe Thr Val Gln  Tyr Lys Asp 
    2975                 2980                 2985             


Arg Asp  Gly Arg Pro Gln Val  Val Arg Val Arg Gly  Glu Glu Ser 
    2990                 2995                 3000             


Glu Val  Thr Val Gly Gly Leu  Glu Pro Gly Cys Lys  Tyr Lys Met 
    3005                 3010                 3015             


His Leu  Tyr Gly Leu His Glu  Gly Gln Arg Val Gly  Pro Val Ser 
    3020                 3025                 3030             


Ala Val  Gly Val Thr Ala Pro  Lys Asp Glu Ala Glu  Thr Thr Gln 
    3035                 3040                 3045             


Ala Val  Pro Thr Met Thr Pro  Glu Pro Pro Ile Lys  Pro Arg Leu 
    3050                 3055                 3060             


Gly Glu  Leu Thr Val Thr Asp  Ala Thr Pro Asp Ser  Leu Ser Leu 
    3065                 3070                 3075             


Ser Trp  Met Val Pro Glu Gly  Gln Phe Asp His Phe  Leu Val Gln 
    3080                 3085                 3090             


Tyr Arg  Asn Gly Asp Gly Gln  Pro Lys Ala Val Arg  Val Pro Gly 
    3095                 3100                 3105             


His Glu  Asp Gly Val Thr Ile  Ser Gly Leu Glu Pro  Asp His Lys 
    3110                 3115                 3120             


Tyr Lys  Met Asn Leu Tyr Gly  Phe His Gly Gly Gln  Arg Val Gly 
    3125                 3130                 3135             


Pro Val  Ser Ala Ile Gly Val  Thr Glu Glu Glu Thr  Pro Ser Pro 
    3140                 3145                 3150             


Thr Glu  Pro Ser Thr Glu Ala  Pro Glu Ala Pro Glu  Glu Pro Leu 
    3155                 3160                 3165             


Leu Gly  Glu Leu Thr Val Thr  Gly Ser Ser Pro Asp  Ser Leu Ser 
    3170                 3175                 3180             


Leu Ser  Trp Thr Val Pro Gln  Gly Arg Phe Asp Ser  Phe Thr Val 
    3185                 3190                 3195             


Gln Tyr  Lys Asp Arg Asp Gly  Gln Pro Gln Val Val  Arg Val Arg 
    3200                 3205                 3210             


Gly Glu  Glu Ser Glu Val Thr  Val Gly Gly Leu Glu  Pro Gly Arg 
    3215                 3220                 3225             


Lys Tyr  Lys Met His Leu Tyr  Gly Leu His Glu Gly  Gln Arg Val 
    3230                 3235                 3240             


Gly Pro  Val Ser Thr Val Gly  Ile Thr Ala Pro Leu  Pro Thr Pro 
    3245                 3250                 3255             


Leu Pro  Val Glu Pro Arg Leu  Gly Glu Leu Ala Val  Ala Ala Val 
    3260                 3265                 3270             


Thr Ser  Asp Ser Val Gly Leu  Ser Trp Thr Val Ala  Gln Gly Pro 
    3275                 3280                 3285             


Phe Asp  Ser Phe Leu Val Gln  Tyr Arg Asp Ala Gln  Gly Gln Pro 
    3290                 3295                 3300             


Gln Ala  Val Pro Val Ser Gly  Asp Leu Arg Ala Val  Ala Val Ser 
    3305                 3310                 3315             


Gly Leu  Asp Pro Ala Arg Lys  Tyr Lys Phe Leu Leu  Phe Gly Leu 
    3320                 3325                 3330             


Gln Asn  Gly Lys Arg His Gly  Pro Val Pro Val Glu  Ala Arg Thr 
    3335                 3340                 3345             


Ala Pro  Asp Thr Lys Pro Ser  Pro Arg Leu Gly Glu  Leu Thr Val 
    3350                 3355                 3360             


Thr Asp  Ala Thr Pro Asp Ser  Val Gly Leu Ser Trp  Thr Val Pro 
    3365                 3370                 3375             


Glu Gly  Glu Phe Asp Ser Phe  Val Val Gln Tyr Lys  Asp Lys Asp 
    3380                 3385                 3390             


Gly Arg  Leu Gln Val Val Pro  Val Ala Ala Asn Gln  Arg Glu Val 
    3395                 3400                 3405             


Thr Val  Gln Gly Leu Glu Pro  Ser Arg Lys Tyr Arg  Phe Leu Leu 
    3410                 3415                 3420             


Tyr Gly  Leu Ser Gly Arg Lys  Arg Leu Gly Pro Ile  Ser Ala Asp 
    3425                 3430                 3435             


Ser Thr  Thr Ala Pro Leu Glu  Lys Glu Leu Pro Pro  His Leu Gly 
    3440                 3445                 3450             


Glu Leu  Thr Val Ala Glu Glu  Thr Ser Ser Ser Leu  Arg Leu Ser 
    3455                 3460                 3465             


Trp Thr  Val Ala Gln Gly Pro  Phe Asp Ser Phe Val  Val Gln Tyr 
    3470                 3475                 3480             


Arg Asp  Thr Asp Gly Gln Pro  Arg Ala Val Pro Val  Ala Ala Asp 
    3485                 3490                 3495             


Gln Arg  Thr Val Thr Val Glu  Asp Leu Glu Pro Gly  Lys Lys Tyr 
    3500                 3505                 3510             


Lys Phe  Leu Leu Tyr Gly Leu  Leu Gly Gly Lys Arg  Leu Gly Pro 
    3515                 3520                 3525             


Val Ser  Ala Leu Gly Met Thr  Ala Pro Glu Glu Asp  Thr Pro Ala 
    3530                 3535                 3540             


Pro Glu  Leu Ala Pro Glu Ala  Pro Glu Pro Pro Glu  Glu Pro Arg 
    3545                 3550                 3555             


Leu Gly  Val Leu Thr Val Thr  Asp Thr Thr Pro Asp  Ser Met Arg 
    3560                 3565                 3570             


Leu Ser  Trp Ser Val Ala Gln  Gly Pro Phe Asp Ser  Phe Val Val 
    3575                 3580                 3585             


Gln Tyr  Glu Asp Thr Asn Gly  Gln Pro Gln Ala Leu  Leu Val Asp 
    3590                 3595                 3600             


Gly Asp  Gln Ser Lys Ile Leu  Ile Ser Gly Leu Glu  Pro Ser Thr 
    3605                 3610                 3615             


Pro Tyr  Arg Phe Leu Leu Tyr  Gly Leu His Glu Gly  Lys Arg Leu 
    3620                 3625                 3630             


Gly Pro  Leu Ser Ala Glu Gly  Thr Thr Gly Leu Ala  Pro Ala Gly 
    3635                 3640                 3645             


Gln Thr  Ser Glu Glu Ser Arg  Pro Arg Leu Ser Gln  Leu Ser Val 
    3650                 3655                 3660             


Thr Asp  Val Thr Thr Ser Ser  Leu Arg Leu Asn Trp  Glu Ala Pro 
    3665                 3670                 3675             


Pro Gly  Ala Phe Asp Ser Phe  Leu Leu Arg Phe Gly  Val Pro Ser 
    3680                 3685                 3690             


Pro Ser  Thr Leu Glu Pro His  Pro Arg Pro Leu Leu  Gln Arg Glu 
    3695                 3700                 3705             


Leu Met  Val Pro Gly Thr Arg  His Ser Ala Val Leu  Arg Asp Leu 
    3710                 3715                 3720             


Arg Ser  Gly Thr Leu Tyr Ser  Leu Thr Leu Tyr Gly  Leu Arg Gly 
    3725                 3730                 3735             


Pro His  Lys Ala Asp Ser Ile  Gln Gly Thr Ala Arg  Thr Leu Ser 
    3740                 3745                 3750             


Pro Val  Leu Glu Ser Pro Arg  Asp Leu Gln Phe Ser  Glu Ile Arg 
    3755                 3760                 3765             


Glu Thr  Ser Ala Lys Val Asn  Trp Met Pro Pro Pro  Ser Arg Ala 
    3770                 3775                 3780             


Asp Ser  Phe Lys Val Ser Tyr  Gln Leu Ala Asp Gly  Gly Glu Pro 
    3785                 3790                 3795             


Gln Ser  Val Gln Val Asp Gly  Gln Ala Arg Thr Gln  Lys Leu Gln 
    3800                 3805                 3810             


Gly Leu  Ile Pro Gly Ala Arg  Tyr Glu Val Thr Val  Val Ser Val 
    3815                 3820                 3825             


Arg Gly  Phe Glu Glu Ser Glu  Pro Leu Thr Gly Phe  Leu Thr Thr 
    3830                 3835                 3840             


Val Pro  Asp Gly Pro Thr Gln  Leu Arg Ala Leu Asn  Leu Thr Glu 
    3845                 3850                 3855             


Gly Phe  Ala Val Leu His Trp  Lys Pro Pro Gln Asn  Pro Val Asp 
    3860                 3865                 3870             


Thr Tyr  Asp Val Gln Val Thr  Ala Pro Gly Ala Pro  Pro Leu Gln 
    3875                 3880                 3885             


Ala Glu  Thr Pro Gly Ser Ala  Val Asp Tyr Pro Leu  His Asp Leu 
    3890                 3895                 3900             


Val Leu  His Thr Asn Tyr Thr  Ala Thr Val Arg Gly  Leu Arg Gly 
    3905                 3910                 3915             


Pro Asn  Leu Thr Ser Pro Ala  Ser Ile Thr Phe Thr  Thr Gly Leu 
    3920                 3925                 3930             


Glu Ala  Pro Arg Asp Leu Glu  Ala Lys Glu Val Thr  Pro Arg Thr 
    3935                 3940                 3945             


Ala Leu  Leu Thr Trp Thr Glu  Pro Pro Val Arg Pro  Ala Gly Tyr 
    3950                 3955                 3960             


Leu Leu  Ser Phe His Thr Pro  Gly Gly Gln Asn Gln  Glu Ile Leu 
    3965                 3970                 3975             


Leu Pro  Gly Gly Ile Thr Ser  His Gln Leu Leu Gly  Leu Phe Pro 
    3980                 3985                 3990             


Ser Thr  Ser Tyr Asn Ala Arg  Leu Gln Ala Met Trp  Gly Gln Ser 
    3995                 4000                 4005             


Leu Leu  Pro Pro Val Ser Thr  Ser Phe Thr Thr Gly  Gly Leu Arg 
    4010                 4015                 4020             


Ile Pro  Phe Pro Arg Asp Cys  Gly Glu Glu Met Gln  Asn Gly Ala 
    4025                 4030                 4035             


Gly Ala  Ser Arg Thr Ser Thr  Ile Phe Leu Asn Gly  Asn Arg Glu 
    4040                 4045                 4050             


Arg Pro  Leu Asn Val Phe Cys  Asp Met Glu Thr Asp  Gly Gly Gly 
    4055                 4060                 4065             


Trp Leu  Val Phe Gln Arg Arg  Met Asp Gly Gln Thr  Asp Phe Trp 
    4070                 4075                 4080             


Arg Asp  Trp Glu Asp Tyr Ala  His Gly Phe Gly Asn  Ile Ser Gly 
    4085                 4090                 4095             


Glu Phe  Trp Leu Gly Asn Glu  Ala Leu His Ser Leu  Thr Gln Ala 
    4100                 4105                 4110             


Gly Asp  Tyr Ser Met Arg Val  Asp Leu Arg Ala Gly  Asp Glu Ala 
    4115                 4120                 4125             


Val Phe  Ala Gln Tyr Asp Ser  Phe His Val Asp Ser  Ala Ala Glu 
    4130                 4135                 4140             


Tyr Tyr  Arg Leu His Leu Glu  Gly Tyr His Gly Thr  Ala Gly Asp 
    4145                 4150                 4155             


Ser Met  Ser Tyr His Ser Gly  Ser Val Phe Ser Ala  Arg Asp Arg 
    4160                 4165                 4170             


Asp Pro  Asn Ser Leu Leu Ile  Ser Cys Ala Val Ser  Tyr Arg Gly 
    4175                 4180                 4185             


Ala Trp  Trp Tyr Arg Asn Cys  His Tyr Ala Asn Leu  Asn Gly Leu 
    4190                 4195                 4200             


Tyr Gly  Ser Thr Val Asp His  Gln Gly Val Ser Trp  Tyr His Trp 
    4205                 4210                 4215             


Lys Gly  Phe Glu Phe Ser Val  Pro Phe Thr Glu Met  Lys Leu Arg 
    4220                 4225                 4230             


Pro Arg  Asn Phe Arg Ser Pro  Ala Gly Gly Gly 
    4235                 4240                 


<210>  111
<211>  4242
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Met Pro Ala Gln Tyr Ala Leu Thr Ser Ser Leu Val Leu Leu Val 
1               5                   10                  15      


Leu Leu Ser Thr Ala Arg Ala Gly Pro Phe Ser Ser Arg Ser Asn Val 
            20                  25                  30          


Thr Leu Pro Ala Pro Arg Pro Pro Pro Gln Pro Gly Gly His Thr Val 
        35                  40                  45              


Gly Ala Gly Val Gly Ser Pro Ser Ser Gln Leu Tyr Glu His Thr Val 
    50                  55                  60                  


Glu Gly Gly Glu Lys Gln Val Val Phe Thr His Arg Ile Asn Leu Pro 
65                  70                  75                  80  


Pro Ser Thr Gly Cys Gly Cys Pro Pro Gly Thr Glu Pro Pro Val Leu 
                85                  90                  95      


Ala Ser Glu Val Gln Ala Leu Arg Val Arg Leu Glu Ile Leu Glu Glu 
            100                 105                 110         


Leu Val Lys Gly Leu Lys Glu Gln Cys Thr Gly Gly Cys Cys Pro Ala 
        115                 120                 125             


Ser Ala Gln Ala Gly Thr Gly Gln Thr Asp Val Arg Thr Leu Cys Ser 
    130                 135                 140                 


Leu His Gly Val Phe Asp Leu Ser Arg Cys Thr Cys Ser Cys Glu Pro 
145                 150                 155                 160 


Gly Trp Gly Gly Pro Thr Cys Ser Asp Pro Thr Asp Ala Glu Ile Pro 
                165                 170                 175     


Pro Ser Ser Pro Pro Ser Ala Ser Gly Ser Cys Pro Asp Asp Cys Asn 
            180                 185                 190         


Asp Gln Gly Arg Cys Val Arg Gly Arg Cys Val Cys Phe Pro Gly Tyr 
        195                 200                 205             


Thr Gly Pro Ser Cys Gly Trp Pro Ser Cys Pro Gly Asp Cys Gln Gly 
    210                 215                 220                 


Arg Gly Arg Cys Val Gln Gly Val Cys Val Cys Arg Ala Gly Phe Ser 
225                 230                 235                 240 


Gly Pro Asp Cys Ser Gln Arg Ser Cys Pro Arg Gly Cys Ser Gln Arg 
                245                 250                 255     


Gly Arg Cys Glu Gly Gly Arg Cys Val Cys Asp Pro Gly Tyr Thr Gly 
            260                 265                 270         


Asp Asp Cys Gly Met Arg Ser Cys Pro Arg Gly Cys Ser Gln Arg Gly 
        275                 280                 285             


Arg Cys Glu Asn Gly Arg Cys Val Cys Asn Pro Gly Tyr Thr Gly Glu 
    290                 295                 300                 


Asp Cys Gly Val Arg Ser Cys Pro Arg Gly Cys Ser Gln Arg Gly Arg 
305                 310                 315                 320 


Cys Lys Asp Gly Arg Cys Val Cys Asp Pro Gly Tyr Thr Gly Glu Asp 
                325                 330                 335     


Cys Gly Thr Arg Ser Cys Pro Trp Asp Cys Gly Glu Gly Gly Arg Cys 
            340                 345                 350         


Val Asp Gly Arg Cys Val Cys Trp Pro Gly Tyr Thr Gly Glu Asp Cys 
        355                 360                 365             


Ser Thr Arg Thr Cys Pro Arg Asp Cys Arg Gly Arg Gly Arg Cys Glu 
    370                 375                 380                 


Asp Gly Glu Cys Ile Cys Asp Thr Gly Tyr Ser Gly Asp Asp Cys Gly 
385                 390                 395                 400 


Val Arg Ser Cys Pro Gly Asp Cys Asn Gln Arg Gly Arg Cys Glu Asp 
                405                 410                 415     


Gly Arg Cys Val Cys Trp Pro Gly Tyr Thr Gly Thr Asp Cys Gly Ser 
            420                 425                 430         


Arg Ala Cys Pro Arg Asp Cys Arg Gly Arg Gly Arg Cys Glu Asn Gly 
        435                 440                 445             


Val Cys Val Cys Asn Ala Gly Tyr Ser Gly Glu Asp Cys Gly Val Arg 
    450                 455                 460                 


Ser Cys Pro Gly Asp Cys Arg Gly Arg Gly Arg Cys Glu Ser Gly Arg 
465                 470                 475                 480 


Cys Met Cys Trp Pro Gly Tyr Thr Gly Arg Asp Cys Gly Thr Arg Ala 
                485                 490                 495     


Cys Pro Gly Asp Cys Arg Gly Arg Gly Arg Cys Val Asp Gly Arg Cys 
            500                 505                 510         


Val Cys Asn Pro Gly Phe Thr Gly Glu Asp Cys Gly Ser Arg Arg Cys 
        515                 520                 525             


Pro Gly Asp Cys Arg Gly His Gly Leu Cys Glu Asp Gly Val Cys Val 
    530                 535                 540                 


Cys Asp Ala Gly Tyr Ser Gly Glu Asp Cys Ser Thr Arg Ser Cys Pro 
545                 550                 555                 560 


Gly Gly Cys Arg Gly Arg Gly Gln Cys Leu Asp Gly Arg Cys Val Cys 
                565                 570                 575     


Glu Asp Gly Tyr Ser Gly Glu Asp Cys Gly Val Arg Gln Cys Pro Asn 
            580                 585                 590         


Asp Cys Ser Gln His Gly Val Cys Gln Asp Gly Val Cys Ile Cys Trp 
        595                 600                 605             


Glu Gly Tyr Val Ser Glu Asp Cys Ser Ile Arg Thr Cys Pro Ser Asn 
    610                 615                 620                 


Cys His Gly Arg Gly Arg Cys Glu Glu Gly Arg Cys Leu Cys Asp Pro 
625                 630                 635                 640 


Gly Tyr Thr Gly Pro Thr Cys Ala Thr Arg Met Cys Pro Ala Asp Cys 
                645                 650                 655     


Arg Gly Arg Gly Arg Cys Val Gln Gly Val Cys Leu Cys His Val Gly 
            660                 665                 670         


Tyr Gly Gly Glu Asp Cys Gly Gln Glu Glu Pro Pro Ala Ser Ala Cys 
        675                 680                 685             


Pro Gly Gly Cys Gly Pro Arg Glu Leu Cys Arg Ala Gly Gln Cys Val 
    690                 695                 700                 


Cys Val Glu Gly Phe Arg Gly Pro Asp Cys Ala Ile Gln Thr Cys Pro 
705                 710                 715                 720 


Gly Asp Cys Arg Gly Arg Gly Glu Cys His Asp Gly Ser Cys Val Cys 
                725                 730                 735     


Lys Asp Gly Tyr Ala Gly Glu Asp Cys Gly Glu Glu Val Pro Thr Ile 
            740                 745                 750         


Glu Gly Met Arg Met His Leu Leu Glu Glu Thr Thr Val Arg Thr Glu 
        755                 760                 765             


Trp Thr Pro Ala Pro Gly Pro Val Asp Ala Tyr Glu Ile Gln Phe Ile 
    770                 775                 780                 


Pro Thr Thr Glu Gly Ala Ser Pro Pro Phe Thr Ala Arg Val Pro Ser 
785                 790                 795                 800 


Ser Ala Ser Ala Tyr Asp Gln Arg Gly Leu Ala Pro Gly Gln Glu Tyr 
                805                 810                 815     


Gln Val Thr Val Arg Ala Leu Arg Gly Thr Ser Trp Gly Leu Pro Ala 
            820                 825                 830         


Ser Lys Thr Ile Thr Thr Met Ile Asp Gly Pro Gln Asp Leu Arg Val 
        835                 840                 845             


Val Ala Val Thr Pro Thr Thr Leu Glu Leu Gly Trp Leu Arg Pro Gln 
    850                 855                 860                 


Ala Glu Val Asp Arg Phe Val Val Ser Tyr Val Ser Ala Gly Asn Gln 
865                 870                 875                 880 


Arg Val Arg Leu Glu Val Pro Pro Glu Ala Asp Gly Thr Leu Leu Thr 
                885                 890                 895     


Asp Leu Met Pro Gly Val Glu Tyr Val Val Thr Val Thr Ala Glu Arg 
            900                 905                 910         


Gly Arg Ala Val Ser Tyr Pro Ala Ser Val Arg Ala Asn Thr Gly Ser 
        915                 920                 925             


Ser Pro Leu Gly Leu Leu Gly Thr Thr Asp Glu Pro Pro Pro Ser Gly 
    930                 935                 940                 


Pro Ser Thr Thr Gln Gly Ala Gln Ala Pro Leu Leu Gln Gln Arg Pro 
945                 950                 955                 960 


Gln Glu Leu Gly Glu Leu Arg Val Leu Gly Arg Asp Glu Thr Gly Arg 
                965                 970                 975     


Leu Arg Val Val Trp Thr Ala Gln Pro Asp Thr Phe Ala Tyr Phe Gln 
            980                 985                 990         


Leu Arg Met Arg Val Pro Glu Gly  Pro Gly Ala His Glu  Glu Val Leu 
        995                 1000                 1005             


Pro Gly  Asp Val Arg Gln Ala  Leu Val Pro Pro Pro  Pro Pro Gly 
    1010                 1015                 1020             


Thr Pro  Tyr Glu Leu Ser Leu  His Gly Val Pro Pro  Gly Gly Lys 
    1025                 1030                 1035             


Pro Ser  Asp Pro Ile Ile Tyr  Gln Gly Ile Met Asp  Lys Asp Glu 
    1040                 1045                 1050             


Glu Lys  Pro Gly Lys Ser Ser  Gly Pro Pro Arg Leu  Gly Glu Leu 
    1055                 1060                 1065             


Thr Val  Thr Asp Arg Thr Ser  Asp Ser Leu Leu Leu  Arg Trp Thr 
    1070                 1075                 1080             


Val Pro  Glu Gly Glu Phe Asp  Ser Phe Val Ile Gln  Tyr Lys Asp 
    1085                 1090                 1095             


Arg Asp  Gly Gln Pro Gln Val  Val Pro Val Glu Gly  Pro Gln Arg 
    1100                 1105                 1110             


Ser Ala  Val Ile Thr Ser Leu  Asp Pro Gly Arg Lys  Tyr Lys Phe 
    1115                 1120                 1125             


Val Leu  Tyr Gly Phe Val Gly  Lys Lys Arg His Gly  Pro Leu Val 
    1130                 1135                 1140             


Ala Glu  Ala Lys Ile Leu Pro  Gln Ser Asp Pro Ser  Pro Gly Thr 
    1145                 1150                 1155             


Pro Pro  His Leu Gly Asn Leu  Trp Val Thr Asp Pro  Thr Pro Asp 
    1160                 1165                 1170             


Ser Leu  His Leu Ser Trp Thr  Val Pro Glu Gly Gln  Phe Asp Thr 
    1175                 1180                 1185             


Phe Met  Val Gln Tyr Arg Asp  Arg Asp Gly Arg Pro  Gln Val Val 
    1190                 1195                 1200             


Pro Val  Glu Gly Pro Glu Arg  Ser Phe Val Val Ser  Ser Leu Asp 
    1205                 1210                 1215             


Pro Asp  His Lys Tyr Arg Phe  Thr Leu Phe Gly Ile  Ala Asn Lys 
    1220                 1225                 1230             


Lys Arg  Tyr Gly Pro Leu Thr  Ala Asp Gly Thr Thr  Ala Pro Glu 
    1235                 1240                 1245             


Arg Lys  Glu Glu Pro Pro Arg  Pro Glu Phe Leu Glu  Gln Pro Leu 
    1250                 1255                 1260             


Leu Gly  Glu Leu Thr Val Thr  Gly Val Thr Pro Asp  Ser Leu Arg 
    1265                 1270                 1275             


Leu Ser  Trp Thr Val Ala Gln  Gly Pro Phe Asp Ser  Phe Met Val 
    1280                 1285                 1290             


Gln Tyr  Lys Asp Ala Gln Gly  Gln Pro Gln Ala Val  Pro Val Ala 
    1295                 1300                 1305             


Gly Asp  Glu Asn Glu Val Thr  Val Pro Gly Leu Asp  Pro Asp Arg 
    1310                 1315                 1320             


Lys Tyr  Lys Met Asn Leu Tyr  Gly Leu Arg Gly Arg  Gln Arg Val 
    1325                 1330                 1335             


Gly Pro  Glu Ser Val Val Ala  Lys Thr Ala Pro Gln  Glu Asp Val 
    1340                 1345                 1350             


Asp Glu  Thr Pro Ser Pro Thr  Glu Leu Gly Thr Glu  Ala Pro Glu 
    1355                 1360                 1365             


Ser Pro  Glu Glu Pro Leu Leu  Gly Glu Leu Thr Val  Thr Gly Ser 
    1370                 1375                 1380             


Ser Pro  Asp Ser Leu Ser Leu  Phe Trp Thr Val Pro  Gln Gly Ser 
    1385                 1390                 1395             


Phe Asp  Ser Phe Thr Val Gln  Tyr Lys Asp Arg Asp  Gly Arg Pro 
    1400                 1405                 1410             


Arg Ala  Val Arg Val Gly Gly  Lys Glu Ser Glu Val  Thr Val Gly 
    1415                 1420                 1425             


Gly Leu  Glu Pro Gly His Lys  Tyr Lys Met His Leu  Tyr Gly Leu 
    1430                 1435                 1440             


His Glu  Gly Gln Arg Val Gly  Pro Val Ser Ala Val  Gly Val Thr 
    1445                 1450                 1455             


Ala Pro  Gln Gln Glu Glu Thr  Pro Pro Ala Thr Glu  Ser Pro Leu 
    1460                 1465                 1470             


Glu Pro  Arg Leu Gly Glu Leu  Thr Val Thr Asp Val  Thr Pro Asn 
    1475                 1480                 1485             


Ser Val  Gly Leu Ser Trp Thr  Val Pro Glu Gly Gln  Phe Asp Ser 
    1490                 1495                 1500             


Phe Ile  Val Gln Tyr Lys Asp  Lys Asp Gly Gln Pro  Gln Val Val 
    1505                 1510                 1515             


Pro Val  Ala Ala Asp Gln Arg  Glu Val Thr Val Tyr  Asn Leu Glu 
    1520                 1525                 1530             


Pro Glu  Arg Lys Tyr Lys Met  Asn Met Tyr Gly Leu  His Asp Gly 
    1535                 1540                 1545             


Gln Arg  Met Gly Pro Leu Ser  Val Val Ile Val Thr  Ala Pro Leu 
    1550                 1555                 1560             


Pro Pro  Ala Pro Ala Thr Glu  Ala Ser Lys Pro Pro  Leu Glu Pro 
    1565                 1570                 1575             


Arg Leu  Gly Glu Leu Thr Val  Thr Asp Ile Thr Pro  Asp Ser Val 
    1580                 1585                 1590             


Gly Leu  Ser Trp Thr Val Pro  Glu Gly Glu Phe Asp  Ser Phe Val 
    1595                 1600                 1605             


Val Gln  Tyr Lys Asp Arg Asp  Gly Gln Pro Gln Val  Val Pro Val 
    1610                 1615                 1620             


Ala Ala  Asp Gln Arg Glu Val  Thr Ile Pro Asp Leu  Glu Pro Ser 
    1625                 1630                 1635             


Arg Lys  Tyr Lys Phe Leu Leu  Phe Gly Ile Gln Asp  Gly Lys Arg 
    1640                 1645                 1650             


Arg Ser  Pro Val Ser Val Glu  Ala Lys Thr Val Ala  Arg Gly Asp 
    1655                 1660                 1665             


Ala Ser  Pro Gly Ala Pro Pro  Arg Leu Gly Glu Leu  Trp Val Thr 
    1670                 1675                 1680             


Asp Pro  Thr Pro Asp Ser Leu  Arg Leu Ser Trp Thr  Val Pro Glu 
    1685                 1690                 1695             


Gly Gln  Phe Asp Ser Phe Val  Val Gln Phe Lys Asp  Lys Asp Gly 
    1700                 1705                 1710             


Pro Gln  Val Val Pro Val Glu  Gly His Glu Arg Ser  Val Thr Val 
    1715                 1720                 1725             


Thr Pro  Leu Asp Ala Gly Arg  Lys Tyr Arg Phe Leu  Leu Tyr Gly 
    1730                 1735                 1740             


Leu Leu  Gly Lys Lys Arg His  Gly Pro Leu Thr Ala  Asp Gly Thr 
    1745                 1750                 1755             


Thr Glu  Ala Arg Ser Ala Met  Asp Asp Thr Gly Thr  Lys Arg Pro 
    1760                 1765                 1770             


Pro Lys  Pro Arg Leu Gly Glu  Glu Leu Gln Val Thr  Thr Val Thr 
    1775                 1780                 1785             


Gln Asn  Ser Val Gly Leu Ser  Trp Thr Val Pro Glu  Gly Gln Phe 
    1790                 1795                 1800             


Asp Ser  Phe Val Val Gln Tyr  Lys Asp Arg Asp Gly  Gln Pro Gln 
    1805                 1810                 1815             


Val Val  Pro Val Glu Gly Ser  Leu Arg Glu Val Ser  Val Pro Gly 
    1820                 1825                 1830             


Leu Asp  Pro Ala His Arg Tyr  Lys Leu Leu Leu Tyr  Gly Leu His 
    1835                 1840                 1845             


His Gly  Lys Arg Val Gly Pro  Ile Ser Ala Val Ala  Ile Thr Ala 
    1850                 1855                 1860             


Gly Arg  Glu Glu Thr Glu Thr  Glu Thr Thr Ala Pro  Thr Pro Pro 
    1865                 1870                 1875             


Ala Pro  Glu Pro His Leu Gly  Glu Leu Thr Val Glu  Glu Ala Thr 
    1880                 1885                 1890             


Ser His  Thr Leu His Leu Ser  Trp Met Val Thr Glu  Gly Glu Phe 
    1895                 1900                 1905             


Asp Ser  Phe Glu Ile Gln Tyr  Thr Asp Arg Asp Gly  Gln Leu Gln 
    1910                 1915                 1920             


Met Val  Arg Ile Gly Gly Asp  Arg Asn Asp Ile Thr  Leu Ser Gly 
    1925                 1930                 1935             


Leu Glu  Ser Asp His Arg Tyr  Leu Val Thr Leu Tyr  Gly Phe Ser 
    1940                 1945                 1950             


Asp Gly  Lys His Val Gly Pro  Val His Val Glu Ala  Leu Thr Val 
    1955                 1960                 1965             


Pro Glu  Glu Glu Lys Pro Ser  Glu Pro Pro Thr Ala  Thr Pro Glu 
    1970                 1975                 1980             


Pro Pro  Ile Lys Pro Arg Leu  Gly Glu Leu Thr Val  Thr Asp Ala 
    1985                 1990                 1995             


Thr Pro  Asp Ser Leu Ser Leu  Ser Trp Thr Val Pro  Glu Gly Gln 
    2000                 2005                 2010             


Phe Asp  His Phe Leu Val Gln  Tyr Arg Asn Gly Asp  Gly Gln Pro 
    2015                 2020                 2025             


Lys Ala  Val Arg Val Pro Gly  His Glu Glu Gly Val  Thr Ile Ser 
    2030                 2035                 2040             


Gly Leu  Glu Pro Asp His Lys  Tyr Lys Met Asn Leu  Tyr Gly Phe 
    2045                 2050                 2055             


His Gly  Gly Gln Arg Met Gly  Pro Val Ser Val Val  Gly Val Thr 
    2060                 2065                 2070             


Ala Ala  Glu Glu Glu Thr Pro  Ser Pro Thr Glu Pro  Ser Met Glu 
    2075                 2080                 2085             


Ala Pro  Glu Pro Ala Glu Glu  Pro Leu Leu Gly Glu  Leu Thr Val 
    2090                 2095                 2100             


Thr Gly  Ser Ser Pro Asp Ser  Leu Ser Leu Ser Trp  Thr Val Pro 
    2105                 2110                 2115             


Gln Gly  Arg Phe Asp Ser Phe  Thr Val Gln Tyr Lys  Asp Arg Asp 
    2120                 2125                 2130             


Gly Arg  Pro Gln Val Val Arg  Val Gly Gly Glu Glu  Ser Glu Val 
    2135                 2140                 2145             


Thr Val  Gly Gly Leu Glu Pro  Gly Arg Lys Tyr Lys  Met His Leu 
    2150                 2155                 2160             


Tyr Gly  Leu His Glu Gly Arg  Arg Val Gly Pro Val  Ser Ala Val 
    2165                 2170                 2175             


Gly Val  Thr Ala Pro Glu Glu  Glu Ser Pro Asp Ala  Pro Leu Ala 
    2180                 2185                 2190             


Lys Leu  Arg Leu Gly Gln Met  Thr Val Arg Asp Ile  Thr Ser Asp 
    2195                 2200                 2205             


Ser Leu  Ser Leu Ser Trp Thr  Val Pro Glu Gly Gln  Phe Asp His 
    2210                 2215                 2220             


Phe Leu  Val Gln Phe Lys Asn  Gly Asp Gly Gln Pro  Lys Ala Val 
    2225                 2230                 2235             


Arg Val  Pro Gly His Glu Asp  Gly Val Thr Ile Ser  Gly Leu Glu 
    2240                 2245                 2250             


Pro Asp  His Lys Tyr Lys Met  Asn Leu Tyr Gly Phe  His Gly Gly 
    2255                 2260                 2265             


Gln Arg  Val Gly Pro Val Ser  Ala Val Gly Leu Thr  Ala Pro Gly 
    2270                 2275                 2280             


Lys Asp  Glu Glu Met Ala Pro  Ala Ser Thr Glu Pro  Pro Thr Pro 
    2285                 2290                 2295             


Glu Pro  Pro Ile Lys Pro Arg  Leu Glu Glu Leu Thr  Val Thr Asp 
    2300                 2305                 2310             


Ala Thr  Pro Asp Ser Leu Ser  Leu Ser Trp Thr Val  Pro Glu Gly 
    2315                 2320                 2325             


Gln Phe  Asp His Phe Leu Val  Gln Tyr Lys Asn Gly  Asp Gly Gln 
    2330                 2335                 2340             


Pro Lys  Ala Thr Arg Val Pro  Gly His Glu Asp Arg  Val Thr Ile 
    2345                 2350                 2355             


Ser Gly  Leu Glu Pro Asp Asn  Lys Tyr Lys Met Asn  Leu Tyr Gly 
    2360                 2365                 2370             


Phe His  Gly Gly Gln Arg Val  Gly Pro Val Ser Ala  Ile Gly Val 
    2375                 2380                 2385             


Thr Ala  Ala Glu Glu Glu Thr  Pro Ser Pro Thr Glu  Pro Ser Met 
    2390                 2395                 2400             


Glu Ala  Pro Glu Pro Pro Glu  Glu Pro Leu Leu Gly  Glu Leu Thr 
    2405                 2410                 2415             


Val Thr  Gly Ser Ser Pro Asp  Ser Leu Ser Leu Ser  Trp Thr Val 
    2420                 2425                 2430             


Pro Gln  Gly Arg Phe Asp Ser  Phe Thr Val Gln Tyr  Lys Asp Arg 
    2435                 2440                 2445             


Asp Gly  Arg Pro Gln Val Val  Arg Val Gly Gly Glu  Glu Ser Glu 
    2450                 2455                 2460             


Val Thr  Val Gly Gly Leu Glu  Pro Gly Arg Lys Tyr  Lys Met His 
    2465                 2470                 2475             


Leu Tyr  Gly Leu His Glu Gly  Arg Arg Val Gly Pro  Val Ser Thr 
    2480                 2485                 2490             


Val Gly  Val Thr Ala Pro Gln  Glu Asp Val Asp Glu  Thr Pro Ser 
    2495                 2500                 2505             


Pro Thr  Glu Pro Gly Thr Glu  Ala Pro Gly Pro Pro  Glu Glu Pro 
    2510                 2515                 2520             


Leu Leu  Gly Glu Leu Thr Val  Thr Gly Ser Ser Pro  Asp Ser Leu 
    2525                 2530                 2535             


Ser Leu  Ser Trp Thr Val Pro  Gln Gly Arg Phe Asp  Ser Phe Thr 
    2540                 2545                 2550             


Val Gln  Tyr Lys Asp Arg Asp  Gly Arg Pro Gln Ala  Val Arg Val 
    2555                 2560                 2565             


Gly Gly  Gln Glu Ser Lys Val  Thr Val Arg Gly Leu  Glu Pro Gly 
    2570                 2575                 2580             


Arg Lys  Tyr Lys Met His Leu  Tyr Gly Leu His Glu  Gly Arg Arg 
    2585                 2590                 2595             


Leu Gly  Pro Val Ser Ala Val  Gly Val Thr Glu Asp  Glu Ala Glu 
    2600                 2605                 2610             


Thr Thr  Gln Ala Val Pro Thr  Met Thr Pro Glu Pro  Pro Ile Lys 
    2615                 2620                 2625             


Pro Arg  Leu Gly Glu Leu Thr  Met Thr Asp Ala Thr  Pro Asp Ser 
    2630                 2635                 2640             


Leu Ser  Leu Ser Trp Thr Val  Pro Glu Gly Gln Phe  Asp His Phe 
    2645                 2650                 2655             


Leu Val  Gln Tyr Arg Asn Gly  Asp Gly Gln Pro Lys  Ala Val Arg 
    2660                 2665                 2670             


Val Pro  Gly His Glu Asp Gly  Val Thr Ile Ser Gly  Leu Glu Pro 
    2675                 2680                 2685             


Asp His  Lys Tyr Lys Met Asn  Leu Tyr Gly Phe His  Gly Gly Gln 
    2690                 2695                 2700             


Arg Val  Gly Pro Ile Ser Val  Ile Gly Val Thr Ala  Ala Glu Glu 
    2705                 2710                 2715             


Glu Thr  Pro Ser Pro Thr Glu  Leu Ser Thr Glu Ala  Pro Glu Pro 
    2720                 2725                 2730             


Pro Glu  Glu Pro Leu Leu Gly  Glu Leu Thr Val Thr  Gly Ser Ser 
    2735                 2740                 2745             


Pro Asp  Ser Leu Ser Leu Ser  Trp Thr Ile Pro Gln  Gly His Phe 
    2750                 2755                 2760             


Asp Ser  Phe Thr Val Gln Tyr  Lys Asp Arg Asp Gly  Arg Pro Gln 
    2765                 2770                 2775             


Val Met  Arg Val Arg Gly Glu  Glu Ser Glu Val Thr  Val Gly Gly 
    2780                 2785                 2790             


Leu Glu  Pro Gly Arg Lys Tyr  Lys Met His Leu Tyr  Gly Leu His 
    2795                 2800                 2805             


Glu Gly  Arg Arg Val Gly Pro  Val Ser Thr Val Gly  Val Thr Glu 
    2810                 2815                 2820             


Asp Glu  Ala Glu Thr Thr Gln  Ala Val Pro Thr Thr  Thr Pro Glu 
    2825                 2830                 2835             


Pro Pro  Asn Lys Pro Arg Leu  Gly Glu Leu Thr Val  Thr Asp Ala 
    2840                 2845                 2850             


Thr Pro  Asp Ser Leu Ser Leu  Ser Trp Met Val Pro  Glu Gly Gln 
    2855                 2860                 2865             


Phe Asp  His Phe Leu Val Gln  Tyr Arg Asn Gly Asp  Gly Gln Pro 
    2870                 2875                 2880             


Lys Val  Val Arg Val Pro Gly  His Glu Asp Gly Val  Thr Ile Ser 
    2885                 2890                 2895             


Gly Leu  Glu Pro Asp His Lys  Tyr Lys Met Asn Leu  Tyr Gly Phe 
    2900                 2905                 2910             


His Gly  Gly Gln Arg Val Gly  Pro Ile Ser Val Ile  Gly Val Thr 
    2915                 2920                 2925             


Ala Ala  Glu Glu Glu Thr Pro  Ala Pro Thr Glu Pro  Ser Thr Glu 
    2930                 2935                 2940             


Ala Pro  Glu Pro Pro Glu Glu  Pro Leu Leu Gly Glu  Leu Thr Val 
    2945                 2950                 2955             


Thr Gly  Ser Ser Pro Asp Ser  Leu Ser Leu Ser Trp  Thr Ile Pro 
    2960                 2965                 2970             


Gln Gly  Arg Phe Asp Ser Phe  Thr Val Gln Tyr Lys  Asp Arg Asp 
    2975                 2980                 2985             


Gly Arg  Pro Gln Val Val Arg  Val Arg Gly Glu Glu  Ser Glu Val 
    2990                 2995                 3000             


Thr Val  Gly Gly Leu Glu Pro  Gly Cys Lys Tyr Lys  Met His Leu 
    3005                 3010                 3015             


Tyr Gly  Leu His Glu Gly Gln  Arg Val Gly Pro Val  Ser Ala Val 
    3020                 3025                 3030             


Gly Val  Thr Ala Pro Lys Asp  Glu Ala Glu Thr Thr  Gln Ala Val 
    3035                 3040                 3045             


Pro Thr  Met Thr Pro Glu Pro  Pro Ile Lys Pro Arg  Leu Gly Glu 
    3050                 3055                 3060             


Leu Thr  Val Thr Asp Ala Thr  Pro Asp Ser Leu Ser  Leu Ser Trp 
    3065                 3070                 3075             


Met Val  Pro Glu Gly Gln Phe  Asp His Phe Leu Val  Gln Tyr Arg 
    3080                 3085                 3090             


Asn Gly  Asp Gly Gln Pro Lys  Ala Val Arg Val Pro  Gly His Glu 
    3095                 3100                 3105             


Asp Gly  Val Thr Ile Ser Gly  Leu Glu Pro Asp His  Lys Tyr Lys 
    3110                 3115                 3120             


Met Asn  Leu Tyr Gly Phe His  Gly Gly Gln Arg Val  Gly Pro Val 
    3125                 3130                 3135             


Ser Ala  Ile Gly Val Thr Glu  Glu Glu Thr Pro Ser  Pro Thr Glu 
    3140                 3145                 3150             


Pro Ser  Thr Glu Ala Pro Glu  Ala Pro Glu Glu Pro  Leu Leu Gly 
    3155                 3160                 3165             


Glu Leu  Thr Val Thr Gly Ser  Ser Pro Asp Ser Leu  Ser Leu Ser 
    3170                 3175                 3180             


Trp Thr  Val Pro Gln Gly Arg  Phe Asp Ser Phe Thr  Val Gln Tyr 
    3185                 3190                 3195             


Lys Asp  Arg Asp Gly Gln Pro  Gln Val Val Arg Val  Arg Gly Glu 
    3200                 3205                 3210             


Glu Ser  Glu Val Thr Val Gly  Gly Leu Glu Pro Gly  Arg Lys Tyr 
    3215                 3220                 3225             


Lys Met  His Leu Tyr Gly Leu  His Glu Gly Gln Arg  Val Gly Pro 
    3230                 3235                 3240             


Val Ser  Thr Val Gly Ile Thr  Ala Pro Leu Pro Thr  Pro Leu Pro 
    3245                 3250                 3255             


Val Glu  Pro Arg Leu Gly Glu  Leu Ala Val Ala Ala  Val Thr Ser 
    3260                 3265                 3270             


Asp Ser  Val Gly Leu Ser Trp  Thr Val Ala Gln Gly  Pro Phe Asp 
    3275                 3280                 3285             


Ser Phe  Leu Val Gln Tyr Arg  Asp Ala Gln Gly Gln  Pro Gln Ala 
    3290                 3295                 3300             


Val Pro  Val Ser Gly Asp Leu  Arg Ala Val Ala Val  Ser Gly Leu 
    3305                 3310                 3315             


Asp Pro  Ala Arg Lys Tyr Lys  Phe Leu Leu Phe Gly  Leu Gln Asn 
    3320                 3325                 3330             


Gly Lys  Arg His Gly Pro Val  Pro Val Glu Ala Arg  Thr Ala Pro 
    3335                 3340                 3345             


Asp Thr  Lys Pro Ser Pro Arg  Leu Gly Glu Leu Thr  Val Thr Asp 
    3350                 3355                 3360             


Ala Thr  Pro Asp Ser Val Gly  Leu Ser Trp Thr Val  Pro Glu Gly 
    3365                 3370                 3375             


Glu Phe  Asp Ser Phe Val Val  Gln Tyr Lys Asp Lys  Asp Gly Arg 
    3380                 3385                 3390             


Leu Gln  Val Val Pro Val Ala  Ala Asn Gln Arg Glu  Val Thr Val 
    3395                 3400                 3405             


Gln Gly  Leu Glu Pro Ser Arg  Lys Tyr Arg Phe Leu  Leu Tyr Gly 
    3410                 3415                 3420             


Leu Ser  Gly Arg Lys Arg Leu  Gly Pro Ile Ser Ala  Asp Ser Thr 
    3425                 3430                 3435             


Thr Ala  Pro Leu Glu Lys Glu  Leu Pro Pro His Leu  Gly Glu Leu 
    3440                 3445                 3450             


Thr Val  Ala Glu Glu Thr Ser  Ser Ser Leu Arg Leu  Ser Trp Thr 
    3455                 3460                 3465             


Val Ala  Gln Gly Pro Phe Asp  Ser Phe Val Val Gln  Tyr Arg Asp 
    3470                 3475                 3480             


Thr Asp  Gly Gln Pro Arg Ala  Val Pro Val Ala Ala  Asp Gln Arg 
    3485                 3490                 3495             


Thr Val  Thr Val Glu Asp Leu  Glu Pro Gly Lys Lys  Tyr Lys Phe 
    3500                 3505                 3510             


Leu Leu  Tyr Gly Leu Leu Gly  Gly Lys Arg Leu Gly  Pro Val Ser 
    3515                 3520                 3525             


Ala Leu  Gly Met Thr Ala Pro  Glu Glu Asp Thr Pro  Ala Pro Glu 
    3530                 3535                 3540             


Leu Ala  Pro Glu Ala Pro Glu  Pro Pro Glu Glu Pro  Arg Leu Gly 
    3545                 3550                 3555             


Val Leu  Thr Val Thr Asp Thr  Thr Pro Asp Ser Met  Arg Leu Ser 
    3560                 3565                 3570             


Trp Ser  Val Ala Gln Gly Pro  Phe Asp Ser Phe Val  Val Gln Tyr 
    3575                 3580                 3585             


Glu Asp  Thr Asn Gly Gln Pro  Gln Ala Leu Leu Val  Asp Gly Asp 
    3590                 3595                 3600             


Gln Ser  Lys Ile Leu Ile Ser  Gly Leu Glu Pro Ser  Thr Pro Tyr 
    3605                 3610                 3615             


Arg Phe  Leu Leu Tyr Gly Leu  His Glu Gly Lys Arg  Leu Gly Pro 
    3620                 3625                 3630             


Leu Ser  Ala Glu Gly Thr Thr  Gly Leu Ala Pro Ala  Gly Gln Thr 
    3635                 3640                 3645             


Ser Glu  Glu Ser Arg Pro Arg  Leu Ser Gln Leu Ser  Val Thr Asp 
    3650                 3655                 3660             


Val Thr  Thr Ser Ser Leu Arg  Leu Asn Trp Glu Ala  Pro Pro Gly 
    3665                 3670                 3675             


Ala Phe  Asp Ser Phe Leu Leu  Arg Phe Gly Val Pro  Ser Pro Ser 
    3680                 3685                 3690             


Thr Leu  Glu Pro His Pro Arg  Pro Leu Leu Gln Arg  Glu Leu Met 
    3695                 3700                 3705             


Val Pro  Gly Thr Arg His Ser  Ala Val Leu Arg Asp  Leu Arg Ser 
    3710                 3715                 3720             


Gly Thr  Leu Tyr Ser Leu Thr  Leu Tyr Gly Leu Arg  Gly Pro His 
    3725                 3730                 3735             


Lys Ala  Asp Ser Ile Gln Gly  Thr Ala Arg Thr Leu  Ser Pro Val 
    3740                 3745                 3750             


Leu Glu  Ser Pro Arg Asp Leu  Gln Phe Ser Glu Ile  Arg Glu Thr 
    3755                 3760                 3765             


Ser Ala  Lys Val Asn Trp Met  Pro Pro Pro Ser Arg  Ala Asp Ser 
    3770                 3775                 3780             


Phe Lys  Val Ser Tyr Gln Leu  Ala Asp Gly Gly Glu  Pro Gln Ser 
    3785                 3790                 3795             


Val Gln  Val Asp Gly Gln Ala  Arg Thr Gln Lys Leu  Gln Gly Leu 
    3800                 3805                 3810             


Ile Pro  Gly Ala Arg Tyr Glu  Val Thr Val Val Ser  Val Arg Gly 
    3815                 3820                 3825             


Phe Glu  Glu Ser Glu Pro Leu  Thr Gly Phe Leu Thr  Thr Val Pro 
    3830                 3835                 3840             


Asp Gly  Pro Thr Gln Leu Arg  Ala Leu Asn Leu Thr  Glu Gly Phe 
    3845                 3850                 3855             


Ala Val  Leu His Trp Lys Pro  Pro Gln Asn Pro Val  Asp Thr Tyr 
    3860                 3865                 3870             


Asp Val  Gln Val Thr Ala Pro  Gly Ala Pro Pro Leu  Gln Ala Glu 
    3875                 3880                 3885             


Thr Pro  Gly Ser Ala Val Asp  Tyr Pro Leu His Asp  Leu Val Leu 
    3890                 3895                 3900             


His Thr  Asn Tyr Thr Ala Thr  Val Arg Gly Leu Arg  Gly Pro Asn 
    3905                 3910                 3915             


Leu Thr  Ser Pro Ala Ser Ile  Thr Phe Thr Thr Gly  Leu Glu Ala 
    3920                 3925                 3930             


Pro Arg  Asp Leu Glu Ala Lys  Glu Val Thr Pro Arg  Thr Ala Leu 
    3935                 3940                 3945             


Leu Thr  Trp Thr Glu Pro Pro  Val Arg Pro Ala Gly  Tyr Leu Leu 
    3950                 3955                 3960             


Ser Phe  His Thr Pro Gly Gly  Gln Asn Gln Glu Ile  Leu Leu Pro 
    3965                 3970                 3975             


Gly Gly  Ile Thr Ser His Gln  Leu Leu Gly Leu Phe  Pro Ser Thr 
    3980                 3985                 3990             


Ser Tyr  Asn Ala Arg Leu Gln  Ala Met Trp Gly Gln  Ser Leu Leu 
    3995                 4000                 4005             


Pro Pro  Val Ser Thr Ser Phe  Thr Thr Gly Gly Leu  Arg Ile Pro 
    4010                 4015                 4020             


Phe Pro  Arg Asp Cys Gly Glu  Glu Met Gln Asn Gly  Ala Gly Ala 
    4025                 4030                 4035             


Ser Arg  Thr Ser Thr Ile Phe  Leu Asn Gly Asn Arg  Glu Arg Pro 
    4040                 4045                 4050             


Leu Asn  Val Phe Cys Asp Met  Glu Thr Asp Gly Gly  Gly Trp Leu 
    4055                 4060                 4065             


Val Phe  Gln Arg Arg Met Asp  Gly Gln Thr Asp Phe  Trp Arg Asp 
    4070                 4075                 4080             


Trp Glu  Asp Tyr Ala His Gly  Phe Gly Asn Ile Ser  Gly Glu Phe 
    4085                 4090                 4095             


Trp Leu  Gly Asn Glu Ala Leu  His Ser Leu Thr Gln  Ala Gly Asp 
    4100                 4105                 4110             


Tyr Ser  Met Arg Val Asp Leu  Arg Ala Gly Asp Glu  Ala Val Phe 
    4115                 4120                 4125             


Ala Gln  Tyr Asp Ser Phe His  Val Asp Ser Ala Ala  Glu Tyr Tyr 
    4130                 4135                 4140             


Arg Leu  His Leu Glu Gly Tyr  His Gly Thr Ala Gly  Asp Ser Met 
    4145                 4150                 4155             


Ser Tyr  His Ser Gly Ser Val  Phe Ser Ala Arg Asp  Arg Asp Pro 
    4160                 4165                 4170             


Asn Ser  Leu Leu Ile Ser Cys  Ala Val Ser Tyr Arg  Gly Ala Trp 
    4175                 4180                 4185             


Trp Tyr  Arg Asn Cys His Tyr  Ala Asn Leu Asn Gly  Leu Tyr Gly 
    4190                 4195                 4200             


Ser Thr  Val Asp His Gln Gly  Val Ser Trp Tyr His  Trp Lys Gly 
    4205                 4210                 4215             


Phe Glu  Phe Ser Val Pro Phe  Thr Glu Met Lys Leu  Arg Pro Arg 
    4220                 4225                 4230             


Asn Phe  Arg Ser Pro Ala Gly  Gly Gly 
    4235                 4240         


<210>  112
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Arg Leu Ser Trp Ser Val Ala Gln Gly Pro Phe Asp Ser Phe Val 
1               5                   10                  15      


Val Gln Tyr Glu Asp Thr Asn Gly Gln Pro Gln Ala Leu Leu Val Asp 
            20                  25                  30          


Gly Asp Gln Ser Lys Ile Leu Ile Ser Gly Leu Glu Pro Ser Thr Pro 
        35                  40                  45              


Tyr Arg Phe Leu Leu Tyr Gly Leu His Glu Gly Lys Arg Leu Gly Pro 
    50                  55                  60                  


Leu Ser Ala Glu Gly Thr Thr Gly Leu Ala Pro Ala Gly Gln Thr Ser 
65                  70                  75                  80  


Glu Glu Ser Arg Pro Arg Leu Ser Gln Leu Ser Val Thr Asp Val Thr 
                85                  90                  95      


Thr Ser Ser Leu Arg Leu Asn Trp Glu Ala Pro Pro Gly Ala Phe Asp 
            100                 105                 110         


Ser Phe Leu Leu Arg Phe Gly Val Pro Ser Pro Ser Thr Leu Glu Pro 
        115                 120                 125             


His Pro Arg Pro Leu Leu Gln Arg Glu Leu Met Val Pro Gly Thr Arg 
    130                 135                 140                 


His Ser Ala Val Leu Arg Asp Leu Arg Ser Gly Thr Leu Tyr Ser Leu 
145                 150                 155                 160 


Thr Leu Tyr Gly Leu Arg Gly Pro His Lys Ala Asp Ser Ile Gln Gly 
                165                 170                 175     


Thr Ala Arg Thr Leu Ser Pro Val Leu Glu Ser Pro Arg Asp Leu Gln 
            180                 185                 190         


Phe Ser Glu Ile Arg Glu Thr Ser Ala Lys Val Asn Trp Met Pro Pro 
        195                 200                 205             


Pro Ser Arg Ala Asp Ser Phe Lys Val Ser Tyr Gln Leu Ala Asp Gly 
    210                 215                 220                 


Gly Glu Pro Gln Ser Val Gln Val Asp Gly Gln Ala Arg Thr Gln Lys 
225                 230                 235                 240 


Leu Gln Gly Leu Ile Pro Gly Ala Arg Tyr Glu Val Thr Val Val Ser 
                245                 250                 255     


Val Arg Gly Phe Glu Glu Ser Glu Pro Leu Thr Gly Phe Leu Thr Thr 
            260                 265                 270         


Val Pro Asp Gly Pro Thr Gln Leu Arg Ala Leu Asn Leu Thr Glu Gly 
        275                 280                 285             


Phe Ala Val Leu His Trp Lys Pro Pro Gln Asn Pro Val Asp Thr Tyr 
    290                 295                 300                 


Asp Val Gln Val Thr Ala Pro Gly Ala Pro Pro Leu Gln Ala Glu Thr 
305                 310                 315                 320 


Pro Gly Ser Ala Val Asp Tyr Pro Leu His Asp Leu Val Leu His Thr 
                325                 330                 335     


Asn Tyr Thr Ala Thr Val Arg Gly Leu Arg Gly Pro Asn Leu Thr Ser 
            340                 345                 350         


Pro Ala Ser Ile Thr Phe Thr Thr Gly Leu Glu Ala Pro Arg Asp Leu 
        355                 360                 365             


Glu Ala Lys Glu Val Thr Pro Arg Thr Ala Leu Leu Thr Trp Thr Glu 
    370                 375                 380                 


Pro Pro Val Arg Pro Ala Gly Tyr Leu Leu Ser Phe His Thr Pro Gly 
385                 390                 395                 400 


Gly Gln Asn Gln Glu Ile Leu Leu Pro Gly Gly Ile Thr Ser His Gln 
                405                 410                 415     


Leu Leu Gly Leu Phe Pro Ser Thr Ser Tyr Asn Ala Arg Leu Gln Ala 
            420                 425                 430         


Met Trp Gly Gln Ser Leu Leu Pro Pro Val Ser Thr Ser Phe Thr Thr 
        435                 440                 445             


Gly Gly Leu Arg Ile Pro Phe Pro Arg Asp Cys Gly Glu Glu Met Gln 
    450                 455                 460                 


Asn Gly Ala Gly Ala Ser Arg Thr Ser Thr Ile Phe Leu Asn Gly Asn 
465                 470                 475                 480 


Arg Glu Arg Pro Leu Asn Val Phe Cys Asp Met Glu Thr Asp Gly Gly 
                485                 490                 495     


Gly Trp Leu Val Phe Gln Arg Arg Met Asp Gly Gln Thr Asp Phe Trp 
            500                 505                 510         


Arg Asp Trp Glu Asp Tyr Ala His Gly Phe Gly Asn Ile Ser Gly Glu 
        515                 520                 525             


Phe Trp Leu Gly Asn Glu Ala Leu His Ser Leu Thr Gln Ala Gly Asp 
    530                 535                 540                 


Tyr Ser Met Arg Val Asp Leu Arg Ala Gly Asp Glu Ala Val Phe Ala 
545                 550                 555                 560 


Gln Tyr Asp Ser Phe His Val Asp Ser Ala Ala Glu Tyr Tyr Arg Leu 
                565                 570                 575     


His Leu Glu Gly Tyr His Gly Thr Ala Gly Asp Ser Met Ser Tyr His 
            580                 585                 590         


Ser Gly Ser Val Phe Ser Ala Arg Asp Arg Asp Pro Asn Ser Leu Leu 
        595                 600                 605             


Ile Ser Cys Ala Val Ser Tyr Arg Gly Ala Trp Trp Tyr Arg Asn Cys 
    610                 615                 620                 


His Tyr Ala Asn Leu Asn Gly Leu Tyr Gly Ser Thr Val Asp His Gln 
625                 630                 635                 640 


Gly Val Ser Trp Tyr His Trp Lys Gly Phe Glu Phe Ser Val Pro Phe 
                645                 650                 655     


Thr Glu Met Lys Leu Arg Pro Arg Asn Phe Arg Ser Pro Ala Gly Gly 
            660                 665                 670         


Gly 
    


<210>  113
<211>  4245
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Met Pro Ala Gln Tyr Ala Leu Thr Ser Ser Leu Val Leu Leu Val 
1               5                   10                  15      


Leu Leu Ser Thr Ala Arg Ala Gly Pro Phe Ser Ser Arg Ser Asn Val 
            20                  25                  30          


Thr Leu Pro Ala Pro Arg Pro Pro Pro Gln Pro Gly Gly His Thr Val 
        35                  40                  45              


Gly Ala Gly Val Gly Ser Pro Ser Ser Gln Leu Tyr Glu His Thr Val 
    50                  55                  60                  


Glu Gly Gly Glu Lys Gln Val Val Phe Thr His Arg Ile Asn Leu Pro 
65                  70                  75                  80  


Pro Ser Thr Gly Cys Gly Cys Pro Pro Gly Thr Glu Pro Pro Val Leu 
                85                  90                  95      


Ala Ser Glu Val Gln Ala Leu Arg Val Arg Leu Glu Ile Leu Glu Glu 
            100                 105                 110         


Leu Val Lys Gly Leu Lys Glu Gln Cys Thr Gly Gly Cys Cys Pro Ala 
        115                 120                 125             


Ser Ala Gln Ala Gly Thr Gly Glu Gln Gly Gln Thr Asp Val Arg Thr 
    130                 135                 140                 


Leu Cys Ser Leu His Gly Val Phe Asp Leu Ser Arg Cys Thr Cys Ser 
145                 150                 155                 160 


Cys Glu Pro Gly Trp Gly Gly Pro Thr Cys Ser Asp Pro Thr Asp Ala 
                165                 170                 175     


Glu Ile Pro Pro Ser Ser Pro Pro Ser Ala Ser Gly Ser Cys Pro Asp 
            180                 185                 190         


Asp Cys Asn Asp Gln Gly Arg Cys Val Arg Gly Arg Cys Val Cys Phe 
        195                 200                 205             


Pro Gly Tyr Thr Gly Pro Ser Cys Gly Trp Pro Ser Cys Pro Gly Asp 
    210                 215                 220                 


Cys Gln Gly Arg Gly Arg Cys Val Gln Gly Val Cys Val Cys Arg Ala 
225                 230                 235                 240 


Gly Phe Ser Gly Pro Asp Cys Ser Gln Arg Ser Cys Pro Arg Gly Cys 
                245                 250                 255     


Ser Gln Arg Gly Arg Cys Glu Gly Gly Arg Cys Val Cys Asp Pro Gly 
            260                 265                 270         


Tyr Thr Gly Asp Asp Cys Gly Met Arg Ser Cys Pro Arg Gly Cys Ser 
        275                 280                 285             


Gln Arg Gly Arg Cys Glu Asn Gly Arg Cys Val Cys Asn Pro Gly Tyr 
    290                 295                 300                 


Thr Gly Glu Asp Cys Gly Val Arg Ser Cys Pro Arg Gly Cys Ser Gln 
305                 310                 315                 320 


Arg Gly Arg Cys Lys Asp Gly Arg Cys Val Cys Asp Pro Gly Tyr Thr 
                325                 330                 335     


Gly Glu Asp Cys Gly Thr Arg Ser Cys Pro Trp Asp Cys Gly Glu Gly 
            340                 345                 350         


Gly Arg Cys Val Asp Gly Arg Cys Val Cys Trp Pro Gly Tyr Thr Gly 
        355                 360                 365             


Glu Asp Cys Ser Thr Arg Thr Cys Pro Arg Asp Cys Arg Gly Arg Gly 
    370                 375                 380                 


Arg Cys Glu Asp Gly Glu Cys Ile Cys Asp Thr Gly Tyr Ser Gly Asp 
385                 390                 395                 400 


Asp Cys Gly Val Arg Ser Cys Pro Gly Asp Cys Asn Gln Arg Gly Arg 
                405                 410                 415     


Cys Glu Asp Gly Arg Cys Val Cys Trp Pro Gly Tyr Thr Gly Thr Asp 
            420                 425                 430         


Cys Gly Ser Arg Ala Cys Pro Arg Asp Cys Arg Gly Arg Gly Arg Cys 
        435                 440                 445             


Glu Asn Gly Val Cys Val Cys Asn Ala Gly Tyr Ser Gly Glu Asp Cys 
    450                 455                 460                 


Gly Val Arg Ser Cys Pro Gly Asp Cys Arg Gly Arg Gly Arg Cys Glu 
465                 470                 475                 480 


Ser Gly Arg Cys Met Cys Trp Pro Gly Tyr Thr Gly Arg Asp Cys Gly 
                485                 490                 495     


Thr Arg Ala Cys Pro Gly Asp Cys Arg Gly Arg Gly Arg Cys Val Asp 
            500                 505                 510         


Gly Arg Cys Val Cys Asn Pro Gly Phe Thr Gly Glu Asp Cys Gly Ser 
        515                 520                 525             


Arg Arg Cys Pro Gly Asp Cys Arg Gly His Gly Leu Cys Glu Asp Gly 
    530                 535                 540                 


Val Cys Val Cys Asp Ala Gly Tyr Ser Gly Glu Asp Cys Ser Thr Arg 
545                 550                 555                 560 


Ser Cys Pro Gly Gly Cys Arg Gly Arg Gly Gln Cys Leu Asp Gly Arg 
                565                 570                 575     


Cys Val Cys Glu Asp Gly Tyr Ser Gly Glu Asp Cys Gly Val Arg Gln 
            580                 585                 590         


Cys Pro Asn Asp Cys Ser Gln His Gly Val Cys Gln Asp Gly Val Cys 
        595                 600                 605             


Ile Cys Trp Glu Gly Tyr Val Ser Glu Asp Cys Ser Ile Arg Thr Cys 
    610                 615                 620                 


Pro Ser Asn Cys His Gly Arg Gly Arg Cys Glu Glu Gly Arg Cys Leu 
625                 630                 635                 640 


Cys Asp Pro Gly Tyr Thr Gly Pro Thr Cys Ala Thr Arg Met Cys Pro 
                645                 650                 655     


Ala Asp Cys Arg Gly Arg Gly Arg Cys Val Gln Gly Val Cys Leu Cys 
            660                 665                 670         


His Val Gly Tyr Gly Gly Glu Asp Cys Gly Gln Glu Glu Pro Pro Ala 
        675                 680                 685             


Ser Ala Cys Pro Gly Gly Cys Gly Pro Arg Glu Leu Cys Arg Ala Gly 
    690                 695                 700                 


Gln Cys Val Cys Val Glu Gly Phe Arg Gly Pro Asp Cys Ala Ile Gln 
705                 710                 715                 720 


Thr Cys Pro Gly Asp Cys Arg Gly Arg Gly Glu Cys His Asp Gly Ser 
                725                 730                 735     


Cys Val Cys Lys Asp Gly Tyr Ala Gly Glu Asp Cys Gly Glu Glu Val 
            740                 745                 750         


Pro Thr Ile Glu Gly Met Arg Met His Leu Leu Glu Glu Thr Thr Val 
        755                 760                 765             


Arg Thr Glu Trp Thr Pro Ala Pro Gly Pro Val Asp Ala Tyr Glu Ile 
    770                 775                 780                 


Gln Phe Ile Pro Thr Thr Glu Gly Ala Ser Pro Pro Phe Thr Ala Arg 
785                 790                 795                 800 


Val Pro Ser Ser Ala Ser Ala Tyr Asp Gln Arg Gly Leu Ala Pro Gly 
                805                 810                 815     


Gln Glu Tyr Gln Val Thr Val Arg Ala Leu Arg Gly Thr Ser Trp Gly 
            820                 825                 830         


Leu Pro Ala Ser Lys Thr Ile Thr Thr Met Ile Asp Gly Pro Gln Asp 
        835                 840                 845             


Leu Arg Val Val Ala Val Thr Pro Thr Thr Leu Glu Leu Gly Trp Leu 
    850                 855                 860                 


Arg Pro Gln Ala Glu Val Asp Arg Phe Val Val Ser Tyr Val Ser Ala 
865                 870                 875                 880 


Gly Asn Gln Arg Val Arg Leu Glu Val Pro Pro Glu Ala Asp Gly Thr 
                885                 890                 895     


Leu Leu Thr Asp Leu Met Pro Gly Val Glu Tyr Val Val Thr Val Thr 
            900                 905                 910         


Ala Glu Arg Gly Arg Ala Val Ser Tyr Pro Ala Ser Val Arg Ala Asn 
        915                 920                 925             


Thr Gly Ser Ser Pro Leu Gly Leu Leu Gly Thr Thr Asp Glu Pro Pro 
    930                 935                 940                 


Pro Ser Gly Pro Ser Thr Thr Gln Gly Ala Gln Ala Pro Leu Leu Gln 
945                 950                 955                 960 


Gln Arg Pro Gln Glu Leu Gly Glu Leu Arg Val Leu Gly Arg Asp Glu 
                965                 970                 975     


Thr Gly Arg Leu Arg Val Val Trp Thr Ala Gln Pro Asp Thr Phe Ala 
            980                 985                 990         


Tyr Phe Gln Leu Arg Met Arg Val  Pro Glu Gly Pro Gly  Ala His Glu 
        995                 1000                 1005             


Glu Val  Leu Pro Gly Asp Val  Arg Gln Ala Leu Val  Pro Pro Pro 
    1010                 1015                 1020             


Pro Pro  Gly Thr Pro Tyr Glu  Leu Ser Leu His Gly  Val Pro Pro 
    1025                 1030                 1035             


Gly Gly  Lys Pro Ser Asp Pro  Ile Ile Tyr Gln Gly  Ile Met Asp 
    1040                 1045                 1050             


Lys Asp  Glu Glu Lys Pro Gly  Lys Ser Ser Gly Pro  Pro Arg Leu 
    1055                 1060                 1065             


Gly Glu  Leu Thr Val Thr Asp  Arg Thr Ser Asp Ser  Leu Leu Leu 
    1070                 1075                 1080             


Arg Trp  Thr Val Pro Glu Gly  Glu Phe Asp Ser Phe  Val Ile Gln 
    1085                 1090                 1095             


Tyr Lys  Asp Arg Asp Gly Gln  Pro Gln Val Val Pro  Val Glu Gly 
    1100                 1105                 1110             


Pro Gln  Arg Ser Ala Val Ile  Thr Ser Leu Asp Pro  Gly Arg Lys 
    1115                 1120                 1125             


Tyr Lys  Phe Val Leu Tyr Gly  Phe Val Gly Lys Lys  Arg His Gly 
    1130                 1135                 1140             


Pro Leu  Val Ala Glu Ala Lys  Ile Leu Pro Gln Ser  Asp Pro Ser 
    1145                 1150                 1155             


Pro Gly  Thr Pro Pro His Leu  Gly Asn Leu Trp Val  Thr Asp Pro 
    1160                 1165                 1170             


Thr Pro  Asp Ser Leu His Leu  Ser Trp Thr Val Pro  Glu Gly Gln 
    1175                 1180                 1185             


Phe Asp  Thr Phe Met Val Gln  Tyr Arg Asp Arg Asp  Gly Arg Pro 
    1190                 1195                 1200             


Gln Val  Val Pro Val Glu Gly  Pro Glu Arg Ser Phe  Val Val Ser 
    1205                 1210                 1215             


Ser Leu  Asp Pro Asp His Lys  Tyr Arg Phe Thr Leu  Phe Gly Ile 
    1220                 1225                 1230             


Ala Asn  Lys Lys Arg Tyr Gly  Pro Leu Thr Ala Asp  Gly Thr Thr 
    1235                 1240                 1245             


Ala Pro  Glu Arg Lys Glu Glu  Pro Pro Arg Pro Glu  Phe Leu Glu 
    1250                 1255                 1260             


Gln Pro  Leu Leu Gly Glu Leu  Thr Val Thr Gly Val  Thr Pro Asp 
    1265                 1270                 1275             


Ser Leu  Arg Leu Ser Trp Thr  Val Ala Gln Gly Pro  Phe Asp Ser 
    1280                 1285                 1290             


Phe Met  Val Gln Tyr Lys Asp  Ala Gln Gly Gln Pro  Gln Ala Val 
    1295                 1300                 1305             


Pro Val  Ala Gly Asp Glu Asn  Glu Val Thr Val Pro  Gly Leu Asp 
    1310                 1315                 1320             


Pro Asp  Arg Lys Tyr Lys Met  Asn Leu Tyr Gly Leu  Arg Gly Arg 
    1325                 1330                 1335             


Gln Arg  Val Gly Pro Glu Ser  Val Val Ala Lys Thr  Ala Pro Gln 
    1340                 1345                 1350             


Glu Asp  Val Asp Glu Thr Pro  Ser Pro Thr Glu Leu  Gly Thr Glu 
    1355                 1360                 1365             


Ala Pro  Glu Ser Pro Glu Glu  Pro Leu Leu Gly Glu  Leu Thr Val 
    1370                 1375                 1380             


Thr Gly  Ser Ser Pro Asp Ser  Leu Ser Leu Phe Trp  Thr Val Pro 
    1385                 1390                 1395             


Gln Gly  Ser Phe Asp Ser Phe  Thr Val Gln Tyr Lys  Asp Arg Asp 
    1400                 1405                 1410             


Gly Arg  Pro Arg Ala Val Arg  Val Gly Gly Lys Glu  Ser Glu Val 
    1415                 1420                 1425             


Thr Val  Gly Gly Leu Glu Pro  Gly His Lys Tyr Lys  Met His Leu 
    1430                 1435                 1440             


Tyr Gly  Leu His Glu Gly Gln  Arg Val Gly Pro Val  Ser Ala Val 
    1445                 1450                 1455             


Gly Val  Thr Ala Pro Gln Gln  Glu Glu Thr Pro Pro  Ala Thr Glu 
    1460                 1465                 1470             


Ser Pro  Leu Glu Pro Arg Leu  Gly Glu Leu Thr Val  Thr Asp Val 
    1475                 1480                 1485             


Thr Pro  Asn Ser Val Gly Leu  Ser Trp Thr Val Pro  Glu Gly Gln 
    1490                 1495                 1500             


Phe Asp  Ser Phe Ile Val Gln  Tyr Lys Asp Lys Asp  Gly Gln Pro 
    1505                 1510                 1515             


Gln Val  Val Pro Val Ala Ala  Asp Gln Arg Glu Val  Thr Val Tyr 
    1520                 1525                 1530             


Asn Leu  Glu Pro Glu Arg Lys  Tyr Lys Met Asn Met  Tyr Gly Leu 
    1535                 1540                 1545             


His Asp  Gly Gln Arg Met Gly  Pro Leu Ser Val Val  Ile Val Thr 
    1550                 1555                 1560             


Ala Pro  Leu Pro Pro Ala Pro  Ala Thr Glu Ala Ser  Lys Pro Pro 
    1565                 1570                 1575             


Leu Glu  Pro Arg Leu Gly Glu  Leu Thr Val Thr Asp  Ile Thr Pro 
    1580                 1585                 1590             


Asp Ser  Val Gly Leu Ser Trp  Thr Val Pro Glu Gly  Glu Phe Asp 
    1595                 1600                 1605             


Ser Phe  Val Val Gln Tyr Lys  Asp Arg Asp Gly Gln  Pro Gln Val 
    1610                 1615                 1620             


Val Pro  Val Ala Ala Asp Gln  Arg Glu Val Thr Ile  Pro Asp Leu 
    1625                 1630                 1635             


Glu Pro  Ser Arg Lys Tyr Lys  Phe Leu Leu Phe Gly  Ile Gln Asp 
    1640                 1645                 1650             


Gly Lys  Arg Arg Ser Pro Val  Ser Val Glu Ala Lys  Thr Val Ala 
    1655                 1660                 1665             


Arg Gly  Asp Ala Ser Pro Gly  Ala Pro Pro Arg Leu  Gly Glu Leu 
    1670                 1675                 1680             


Trp Val  Thr Asp Pro Thr Pro  Asp Ser Leu Arg Leu  Ser Trp Thr 
    1685                 1690                 1695             


Val Pro  Glu Gly Gln Phe Asp  Ser Phe Val Val Gln  Phe Lys Asp 
    1700                 1705                 1710             


Lys Asp  Gly Pro Gln Val Val  Pro Val Glu Gly His  Glu Arg Ser 
    1715                 1720                 1725             


Val Thr  Val Thr Pro Leu Asp  Ala Gly Arg Lys Tyr  Arg Phe Leu 
    1730                 1735                 1740             


Leu Tyr  Gly Leu Leu Gly Lys  Lys Arg His Gly Pro  Leu Thr Ala 
    1745                 1750                 1755             


Asp Gly  Thr Thr Glu Ala Arg  Ser Ala Met Asp Asp  Thr Gly Thr 
    1760                 1765                 1770             


Lys Arg  Pro Pro Lys Pro Arg  Leu Gly Glu Glu Leu  Gln Val Thr 
    1775                 1780                 1785             


Thr Val  Thr Gln Asn Ser Val  Gly Leu Ser Trp Thr  Val Pro Glu 
    1790                 1795                 1800             


Gly Gln  Phe Asp Ser Phe Val  Val Gln Tyr Lys Asp  Arg Asp Gly 
    1805                 1810                 1815             


Gln Pro  Gln Val Val Pro Val  Glu Gly Ser Leu Arg  Glu Val Ser 
    1820                 1825                 1830             


Val Pro  Gly Leu Asp Pro Ala  His Arg Tyr Lys Leu  Leu Leu Tyr 
    1835                 1840                 1845             


Gly Leu  His His Gly Lys Arg  Val Gly Pro Ile Ser  Ala Val Ala 
    1850                 1855                 1860             


Ile Thr  Ala Gly Arg Glu Glu  Thr Glu Thr Glu Thr  Thr Ala Pro 
    1865                 1870                 1875             


Thr Pro  Pro Ala Pro Glu Pro  His Leu Gly Glu Leu  Thr Val Glu 
    1880                 1885                 1890             


Glu Ala  Thr Ser His Thr Leu  His Leu Ser Trp Met  Val Thr Glu 
    1895                 1900                 1905             


Gly Glu  Phe Asp Ser Phe Glu  Ile Gln Tyr Thr Asp  Arg Asp Gly 
    1910                 1915                 1920             


Gln Leu  Gln Met Val Arg Ile  Gly Gly Asp Arg Asn  Asp Ile Thr 
    1925                 1930                 1935             


Leu Ser  Gly Leu Glu Ser Asp  His Arg Tyr Leu Val  Thr Leu Tyr 
    1940                 1945                 1950             


Gly Phe  Ser Asp Gly Lys His  Val Gly Pro Val His  Val Glu Ala 
    1955                 1960                 1965             


Leu Thr  Val Pro Glu Glu Glu  Lys Pro Ser Glu Pro  Pro Thr Ala 
    1970                 1975                 1980             


Thr Pro  Glu Pro Pro Ile Lys  Pro Arg Leu Gly Glu  Leu Thr Val 
    1985                 1990                 1995             


Thr Asp  Ala Thr Pro Asp Ser  Leu Ser Leu Ser Trp  Thr Val Pro 
    2000                 2005                 2010             


Glu Gly  Gln Phe Asp His Phe  Leu Val Gln Tyr Arg  Asn Gly Asp 
    2015                 2020                 2025             


Gly Gln  Pro Lys Ala Val Arg  Val Pro Gly His Glu  Glu Gly Val 
    2030                 2035                 2040             


Thr Ile  Ser Gly Leu Glu Pro  Asp His Lys Tyr Lys  Met Asn Leu 
    2045                 2050                 2055             


Tyr Gly  Phe His Gly Gly Gln  Arg Met Gly Pro Val  Ser Val Val 
    2060                 2065                 2070             


Gly Val  Thr Ala Ala Glu Glu  Glu Thr Pro Ser Pro  Thr Glu Pro 
    2075                 2080                 2085             


Ser Met  Glu Ala Pro Glu Pro  Ala Glu Glu Pro Leu  Leu Gly Glu 
    2090                 2095                 2100             


Leu Thr  Val Thr Gly Ser Ser  Pro Asp Ser Leu Ser  Leu Ser Trp 
    2105                 2110                 2115             


Thr Val  Pro Gln Gly Arg Phe  Asp Ser Phe Thr Val  Gln Tyr Lys 
    2120                 2125                 2130             


Asp Arg  Asp Gly Arg Pro Gln  Val Val Arg Val Gly  Gly Glu Glu 
    2135                 2140                 2145             


Ser Glu  Val Thr Val Gly Gly  Leu Glu Pro Gly Arg  Lys Tyr Lys 
    2150                 2155                 2160             


Met His  Leu Tyr Gly Leu His  Glu Gly Arg Arg Val  Gly Pro Val 
    2165                 2170                 2175             


Ser Ala  Val Gly Val Thr Ala  Pro Glu Glu Glu Ser  Pro Asp Ala 
    2180                 2185                 2190             


Pro Leu  Ala Lys Leu Arg Leu  Gly Gln Met Thr Val  Arg Asp Ile 
    2195                 2200                 2205             


Thr Ser  Asp Ser Leu Ser Leu  Ser Trp Thr Val Pro  Glu Gly Gln 
    2210                 2215                 2220             


Phe Asp  His Phe Leu Val Gln  Phe Lys Asn Gly Asp  Gly Gln Pro 
    2225                 2230                 2235             


Lys Ala  Val Arg Val Pro Gly  His Glu Asp Gly Val  Thr Ile Ser 
    2240                 2245                 2250             


Gly Leu  Glu Pro Asp His Lys  Tyr Lys Met Asn Leu  Tyr Gly Phe 
    2255                 2260                 2265             


His Gly  Gly Gln Arg Val Gly  Pro Val Ser Ala Val  Gly Leu Thr 
    2270                 2275                 2280             


Ala Pro  Gly Lys Asp Glu Glu  Met Ala Pro Ala Ser  Thr Glu Pro 
    2285                 2290                 2295             


Pro Thr  Pro Glu Pro Pro Ile  Lys Pro Arg Leu Glu  Glu Leu Thr 
    2300                 2305                 2310             


Val Thr  Asp Ala Thr Pro Asp  Ser Leu Ser Leu Ser  Trp Thr Val 
    2315                 2320                 2325             


Pro Glu  Gly Gln Phe Asp His  Phe Leu Val Gln Tyr  Lys Asn Gly 
    2330                 2335                 2340             


Asp Gly  Gln Pro Lys Ala Thr  Arg Val Pro Gly His  Glu Asp Arg 
    2345                 2350                 2355             


Val Thr  Ile Ser Gly Leu Glu  Pro Asp Asn Lys Tyr  Lys Met Asn 
    2360                 2365                 2370             


Leu Tyr  Gly Phe His Gly Gly  Gln Arg Val Gly Pro  Val Ser Ala 
    2375                 2380                 2385             


Ile Gly  Val Thr Ala Ala Glu  Glu Glu Thr Pro Ser  Pro Thr Glu 
    2390                 2395                 2400             


Pro Ser  Met Glu Ala Pro Glu  Pro Pro Glu Glu Pro  Leu Leu Gly 
    2405                 2410                 2415             


Glu Leu  Thr Val Thr Gly Ser  Ser Pro Asp Ser Leu  Ser Leu Ser 
    2420                 2425                 2430             


Trp Thr  Val Pro Gln Gly Arg  Phe Asp Ser Phe Thr  Val Gln Tyr 
    2435                 2440                 2445             


Lys Asp  Arg Asp Gly Arg Pro  Gln Val Val Arg Val  Gly Gly Glu 
    2450                 2455                 2460             


Glu Ser  Glu Val Thr Val Gly  Gly Leu Glu Pro Gly  Arg Lys Tyr 
    2465                 2470                 2475             


Lys Met  His Leu Tyr Gly Leu  His Glu Gly Arg Arg  Val Gly Pro 
    2480                 2485                 2490             


Val Ser  Thr Val Gly Val Thr  Ala Pro Gln Glu Asp  Val Asp Glu 
    2495                 2500                 2505             


Thr Pro  Ser Pro Thr Glu Pro  Gly Thr Glu Ala Pro  Gly Pro Pro 
    2510                 2515                 2520             


Glu Glu  Pro Leu Leu Gly Glu  Leu Thr Val Thr Gly  Ser Ser Pro 
    2525                 2530                 2535             


Asp Ser  Leu Ser Leu Ser Trp  Thr Val Pro Gln Gly  Arg Phe Asp 
    2540                 2545                 2550             


Ser Phe  Thr Val Gln Tyr Lys  Asp Arg Asp Gly Arg  Pro Gln Ala 
    2555                 2560                 2565             


Val Arg  Val Gly Gly Gln Glu  Ser Lys Val Thr Val  Arg Gly Leu 
    2570                 2575                 2580             


Glu Pro  Gly Arg Lys Tyr Lys  Met His Leu Tyr Gly  Leu His Glu 
    2585                 2590                 2595             


Gly Arg  Arg Leu Gly Pro Val  Ser Ala Val Gly Val  Thr Glu Asp 
    2600                 2605                 2610             


Glu Ala  Glu Thr Thr Gln Ala  Val Pro Thr Met Thr  Pro Glu Pro 
    2615                 2620                 2625             


Pro Ile  Lys Pro Arg Leu Gly  Glu Leu Thr Met Thr  Asp Ala Thr 
    2630                 2635                 2640             


Pro Asp  Ser Leu Ser Leu Ser  Trp Thr Val Pro Glu  Gly Gln Phe 
    2645                 2650                 2655             


Asp His  Phe Leu Val Gln Tyr  Arg Asn Gly Asp Gly  Gln Pro Lys 
    2660                 2665                 2670             


Ala Val  Arg Val Pro Gly His  Glu Asp Gly Val Thr  Ile Ser Gly 
    2675                 2680                 2685             


Leu Glu  Pro Asp His Lys Tyr  Lys Met Asn Leu Tyr  Gly Phe His 
    2690                 2695                 2700             


Gly Gly  Gln Arg Val Gly Pro  Ile Ser Val Ile Gly  Val Thr Ala 
    2705                 2710                 2715             


Ala Glu  Glu Glu Thr Pro Ser  Pro Thr Glu Leu Ser  Thr Glu Ala 
    2720                 2725                 2730             


Pro Glu  Pro Pro Glu Glu Pro  Leu Leu Gly Glu Leu  Thr Val Thr 
    2735                 2740                 2745             


Gly Ser  Ser Pro Asp Ser Leu  Ser Leu Ser Trp Thr  Ile Pro Gln 
    2750                 2755                 2760             


Gly His  Phe Asp Ser Phe Thr  Val Gln Tyr Lys Asp  Arg Asp Gly 
    2765                 2770                 2775             


Arg Pro  Gln Val Met Arg Val  Arg Gly Glu Glu Ser  Glu Val Thr 
    2780                 2785                 2790             


Val Gly  Gly Leu Glu Pro Gly  Arg Lys Tyr Lys Met  His Leu Tyr 
    2795                 2800                 2805             


Gly Leu  His Glu Gly Arg Arg  Val Gly Pro Val Ser  Thr Val Gly 
    2810                 2815                 2820             


Val Thr  Glu Asp Glu Ala Glu  Thr Thr Gln Ala Val  Pro Thr Thr 
    2825                 2830                 2835             


Thr Pro  Glu Pro Pro Asn Lys  Pro Arg Leu Gly Glu  Leu Thr Val 
    2840                 2845                 2850             


Thr Asp  Ala Thr Pro Asp Ser  Leu Ser Leu Ser Trp  Met Val Pro 
    2855                 2860                 2865             


Glu Gly  Gln Phe Asp His Phe  Leu Val Gln Tyr Arg  Asn Gly Asp 
    2870                 2875                 2880             


Gly Gln  Pro Lys Val Val Arg  Val Pro Gly His Glu  Asp Gly Val 
    2885                 2890                 2895             


Thr Ile  Ser Gly Leu Glu Pro  Asp His Lys Tyr Lys  Met Asn Leu 
    2900                 2905                 2910             


Tyr Gly  Phe His Gly Gly Gln  Arg Val Gly Pro Ile  Ser Val Ile 
    2915                 2920                 2925             


Gly Val  Thr Ala Ala Glu Glu  Glu Thr Pro Ala Pro  Thr Glu Pro 
    2930                 2935                 2940             


Ser Thr  Glu Ala Pro Glu Pro  Pro Glu Glu Pro Leu  Leu Gly Glu 
    2945                 2950                 2955             


Leu Thr  Val Thr Gly Ser Ser  Pro Asp Ser Leu Ser  Leu Ser Trp 
    2960                 2965                 2970             


Thr Ile  Pro Gln Gly Arg Phe  Asp Ser Phe Thr Val  Gln Tyr Lys 
    2975                 2980                 2985             


Asp Arg  Asp Gly Arg Pro Gln  Val Val Arg Val Arg  Gly Glu Glu 
    2990                 2995                 3000             


Ser Glu  Val Thr Val Gly Gly  Leu Glu Pro Gly Cys  Lys Tyr Lys 
    3005                 3010                 3015             


Met His  Leu Tyr Gly Leu His  Glu Gly Gln Arg Val  Gly Pro Val 
    3020                 3025                 3030             


Ser Ala  Val Gly Val Thr Ala  Pro Lys Asp Glu Ala  Glu Thr Thr 
    3035                 3040                 3045             


Gln Ala  Val Pro Thr Met Thr  Pro Glu Pro Pro Ile  Lys Pro Arg 
    3050                 3055                 3060             


Leu Gly  Glu Leu Thr Val Thr  Asp Ala Thr Pro Asp  Ser Leu Ser 
    3065                 3070                 3075             


Leu Ser  Trp Met Val Pro Glu  Gly Gln Phe Asp His  Phe Leu Val 
    3080                 3085                 3090             


Gln Tyr  Arg Asn Gly Asp Gly  Gln Pro Lys Ala Val  Arg Val Pro 
    3095                 3100                 3105             


Gly His  Glu Asp Gly Val Thr  Ile Ser Gly Leu Glu  Pro Asp His 
    3110                 3115                 3120             


Lys Tyr  Lys Met Asn Leu Tyr  Gly Phe His Gly Gly  Gln Arg Val 
    3125                 3130                 3135             


Gly Pro  Val Ser Ala Ile Gly  Val Thr Glu Glu Glu  Thr Pro Ser 
    3140                 3145                 3150             


Pro Thr  Glu Pro Ser Thr Glu  Ala Pro Glu Ala Pro  Glu Glu Pro 
    3155                 3160                 3165             


Leu Leu  Gly Glu Leu Thr Val  Thr Gly Ser Ser Pro  Asp Ser Leu 
    3170                 3175                 3180             


Ser Leu  Ser Trp Thr Val Pro  Gln Gly Arg Phe Asp  Ser Phe Thr 
    3185                 3190                 3195             


Val Gln  Tyr Lys Asp Arg Asp  Gly Gln Pro Gln Val  Val Arg Val 
    3200                 3205                 3210             


Arg Gly  Glu Glu Ser Glu Val  Thr Val Gly Gly Leu  Glu Pro Gly 
    3215                 3220                 3225             


Arg Lys  Tyr Lys Met His Leu  Tyr Gly Leu His Glu  Gly Gln Arg 
    3230                 3235                 3240             


Val Gly  Pro Val Ser Thr Val  Gly Ile Thr Ala Pro  Leu Pro Thr 
    3245                 3250                 3255             


Pro Leu  Pro Val Glu Pro Arg  Leu Gly Glu Leu Ala  Val Ala Ala 
    3260                 3265                 3270             


Val Thr  Ser Asp Ser Val Gly  Leu Ser Trp Thr Val  Ala Gln Gly 
    3275                 3280                 3285             


Pro Phe  Asp Ser Phe Leu Val  Gln Tyr Arg Asp Ala  Gln Gly Gln 
    3290                 3295                 3300             


Pro Gln  Ala Val Pro Val Ser  Gly Asp Leu Arg Ala  Val Ala Val 
    3305                 3310                 3315             


Ser Gly  Leu Asp Pro Ala Arg  Lys Tyr Lys Phe Leu  Leu Phe Gly 
    3320                 3325                 3330             


Leu Gln  Asn Gly Lys Arg His  Gly Pro Val Pro Val  Glu Ala Arg 
    3335                 3340                 3345             


Thr Ala  Pro Asp Thr Lys Pro  Ser Pro Arg Leu Gly  Glu Leu Thr 
    3350                 3355                 3360             


Val Thr  Asp Ala Thr Pro Asp  Ser Val Gly Leu Ser  Trp Thr Val 
    3365                 3370                 3375             


Pro Glu  Gly Glu Phe Asp Ser  Phe Val Val Gln Tyr  Lys Asp Lys 
    3380                 3385                 3390             


Asp Gly  Arg Leu Gln Val Val  Pro Val Ala Ala Asn  Gln Arg Glu 
    3395                 3400                 3405             


Val Thr  Val Gln Gly Leu Glu  Pro Ser Arg Lys Tyr  Arg Phe Leu 
    3410                 3415                 3420             


Leu Tyr  Gly Leu Ser Gly Arg  Lys Arg Leu Gly Pro  Ile Ser Ala 
    3425                 3430                 3435             


Asp Ser  Thr Thr Ala Pro Leu  Glu Lys Glu Leu Pro  Pro His Leu 
    3440                 3445                 3450             


Gly Glu  Leu Thr Val Ala Glu  Glu Thr Ser Ser Ser  Leu Arg Leu 
    3455                 3460                 3465             


Ser Trp  Thr Val Ala Gln Gly  Pro Phe Asp Ser Phe  Val Val Gln 
    3470                 3475                 3480             


Tyr Arg  Asp Thr Asp Gly Gln  Pro Arg Ala Val Pro  Val Ala Ala 
    3485                 3490                 3495             


Asp Gln  Arg Thr Val Thr Val  Glu Asp Leu Glu Pro  Gly Lys Lys 
    3500                 3505                 3510             


Tyr Lys  Phe Leu Leu Tyr Gly  Leu Leu Gly Gly Lys  Arg Leu Gly 
    3515                 3520                 3525             


Pro Val  Ser Ala Leu Gly Met  Thr Ala Pro Glu Glu  Asp Thr Pro 
    3530                 3535                 3540             


Ala Pro  Glu Leu Ala Pro Glu  Ala Pro Glu Pro Pro  Glu Glu Pro 
    3545                 3550                 3555             


Arg Leu  Gly Val Leu Thr Val  Thr Asp Thr Thr Pro  Asp Ser Met 
    3560                 3565                 3570             


Arg Leu  Ser Trp Ser Val Ala  Gln Gly Pro Phe Asp  Ser Phe Val 
    3575                 3580                 3585             


Val Gln  Tyr Glu Asp Thr Asn  Gly Gln Pro Gln Ala  Leu Leu Val 
    3590                 3595                 3600             


Asp Gly  Asp Gln Ser Lys Ile  Leu Ile Ser Gly Leu  Glu Pro Ser 
    3605                 3610                 3615             


Thr Pro  Tyr Arg Phe Leu Leu  Tyr Gly Leu His Glu  Gly Lys Arg 
    3620                 3625                 3630             


Leu Gly  Pro Leu Ser Ala Glu  Gly Thr Thr Gly Leu  Ala Pro Ala 
    3635                 3640                 3645             


Gly Gln  Thr Ser Glu Glu Ser  Arg Pro Arg Leu Ser  Gln Leu Ser 
    3650                 3655                 3660             


Val Thr  Asp Val Thr Thr Ser  Ser Leu Arg Leu Asn  Trp Glu Ala 
    3665                 3670                 3675             


Pro Pro  Gly Ala Phe Asp Ser  Phe Leu Leu Arg Phe  Gly Val Pro 
    3680                 3685                 3690             


Ser Pro  Ser Thr Leu Glu Pro  His Pro Arg Pro Leu  Leu Gln Arg 
    3695                 3700                 3705             


Glu Leu  Met Val Pro Gly Thr  Arg His Ser Ala Val  Leu Arg Asp 
    3710                 3715                 3720             


Leu Arg  Ser Gly Thr Leu Tyr  Ser Leu Thr Leu Tyr  Gly Leu Arg 
    3725                 3730                 3735             


Gly Pro  His Lys Ala Asp Ser  Ile Gln Gly Thr Ala  Arg Thr Leu 
    3740                 3745                 3750             


Ser Pro  Val Leu Glu Ser Pro  Arg Asp Leu Gln Phe  Ser Glu Ile 
    3755                 3760                 3765             


Arg Glu  Thr Ser Ala Lys Val  Asn Trp Met Pro Pro  Pro Ser Arg 
    3770                 3775                 3780             


Ala Asp  Ser Phe Lys Val Ser  Tyr Gln Leu Ala Asp  Gly Gly Glu 
    3785                 3790                 3795             


Pro Gln  Ser Val Gln Val Asp  Gly Gln Ala Arg Thr  Gln Lys Leu 
    3800                 3805                 3810             


Gln Gly  Leu Ile Pro Gly Ala  Arg Tyr Glu Val Thr  Val Val Ser 
    3815                 3820                 3825             


Val Arg  Gly Phe Glu Glu Ser  Glu Pro Leu Thr Gly  Phe Leu Thr 
    3830                 3835                 3840             


Thr Val  Pro Asp Gly Pro Thr  Gln Leu Arg Ala Leu  Asn Leu Thr 
    3845                 3850                 3855             


Glu Gly  Phe Ala Val Leu His  Trp Lys Pro Pro Gln  Asn Pro Val 
    3860                 3865                 3870             


Asp Thr  Tyr Asp Val Gln Val  Thr Ala Pro Gly Ala  Pro Pro Leu 
    3875                 3880                 3885             


Gln Ala  Glu Thr Pro Gly Ser  Ala Val Asp Tyr Pro  Leu His Asp 
    3890                 3895                 3900             


Leu Val  Leu His Thr Asn Tyr  Thr Ala Thr Val Arg  Gly Leu Arg 
    3905                 3910                 3915             


Gly Pro  Asn Leu Thr Ser Pro  Ala Ser Ile Thr Phe  Thr Thr Gly 
    3920                 3925                 3930             


Leu Glu  Ala Pro Arg Asp Leu  Glu Ala Lys Glu Val  Thr Pro Arg 
    3935                 3940                 3945             


Thr Ala  Leu Leu Thr Trp Thr  Glu Pro Pro Val Arg  Pro Ala Gly 
    3950                 3955                 3960             


Tyr Leu  Leu Ser Phe His Thr  Pro Gly Gly Gln Asn  Gln Glu Ile 
    3965                 3970                 3975             


Leu Leu  Pro Gly Gly Ile Thr  Ser His Gln Leu Leu  Gly Leu Phe 
    3980                 3985                 3990             


Pro Ser  Thr Ser Tyr Asn Ala  Arg Leu Gln Ala Met  Trp Gly Gln 
    3995                 4000                 4005             


Ser Leu  Leu Pro Pro Val Ser  Thr Ser Phe Thr Thr  Gly Gly Leu 
    4010                 4015                 4020             


Arg Ile  Pro Phe Pro Arg Asp  Cys Gly Glu Glu Met  Gln Asn Gly 
    4025                 4030                 4035             


Ala Gly  Ala Ser Arg Thr Ser  Thr Ile Phe Leu Asn  Gly Asn Arg 
    4040                 4045                 4050             


Glu Arg  Pro Leu Asn Val Phe  Cys Asp Met Glu Thr  Asp Gly Gly 
    4055                 4060                 4065             


Gly Trp  Leu Val Phe Gln Arg  Arg Met Asp Gly Gln  Thr Asp Phe 
    4070                 4075                 4080             


Trp Arg  Asp Trp Glu Asp Tyr  Ala His Gly Phe Gly  Asn Ile Ser 
    4085                 4090                 4095             


Gly Glu  Phe Trp Leu Gly Asn  Glu Ala Leu His Ser  Leu Thr Gln 
    4100                 4105                 4110             


Ala Gly  Asp Tyr Ser Met Arg  Val Asp Leu Arg Ala  Gly Asp Glu 
    4115                 4120                 4125             


Ala Val  Phe Ala Gln Tyr Asp  Ser Phe His Val Asp  Ser Ala Ala 
    4130                 4135                 4140             


Glu Tyr  Tyr Arg Leu His Leu  Glu Gly Tyr His Gly  Thr Ala Gly 
    4145                 4150                 4155             


Asp Ser  Met Ser Tyr His Ser  Gly Ser Val Phe Ser  Ala Arg Asp 
    4160                 4165                 4170             


Arg Asp  Pro Asn Ser Leu Leu  Ile Ser Cys Ala Val  Ser Tyr Arg 
    4175                 4180                 4185             


Gly Ala  Trp Trp Tyr Arg Asn  Cys His Tyr Ala Asn  Leu Asn Gly 
    4190                 4195                 4200             


Leu Tyr  Gly Ser Thr Val Asp  His Gln Gly Val Ser  Trp Tyr His 
    4205                 4210                 4215             


Trp Lys  Gly Phe Glu Phe Ser  Val Pro Phe Thr Glu  Met Lys Leu 
    4220                 4225                 4230             


Arg Pro  Arg Asn Phe Arg Ser  Pro Ala Gly Gly Gly  
    4235                 4240                 4245 


<210>  114
<211>  408
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Ile Pro Gly Asn Arg Met Leu Met Val Val Leu Leu Cys Gln Val 
1               5                   10                  15      


Leu Leu Gly Gly Ala Ser His Ala Ser Leu Ile Pro Glu Thr Gly Lys 
            20                  25                  30          


Lys Lys Val Ala Glu Ile Gln Gly His Ala Gly Gly Arg Arg Ser Gly 
        35                  40                  45              


Gln Ser His Glu Leu Leu Arg Asp Phe Glu Ala Thr Leu Leu Gln Met 
    50                  55                  60                  


Phe Gly Leu Arg Arg Arg Pro Gln Pro Ser Lys Ser Ala Val Ile Pro 
65                  70                  75                  80  


Asp Tyr Met Arg Asp Leu Tyr Arg Leu Gln Ser Gly Glu Glu Glu Glu 
                85                  90                  95      


Glu Gln Ile His Ser Thr Gly Leu Glu Tyr Pro Glu Arg Pro Ala Ser 
            100                 105                 110         


Arg Ala Asn Thr Val Arg Ser Phe His His Glu Glu His Leu Glu Asn 
        115                 120                 125             


Ile Pro Gly Thr Ser Glu Asn Ser Ala Phe Arg Phe Leu Phe Asn Leu 
    130                 135                 140                 


Ser Ser Ile Pro Glu Asn Glu Val Ile Ser Ser Ala Glu Leu Arg Leu 
145                 150                 155                 160 


Phe Arg Glu Gln Val Asp Gln Gly Pro Asp Trp Glu Arg Gly Phe His 
                165                 170                 175     


Arg Ile Asn Ile Tyr Glu Val Met Lys Pro Pro Ala Glu Val Val Pro 
            180                 185                 190         


Gly His Leu Ile Thr Arg Leu Leu Asp Thr Arg Leu Val His His Asn 
        195                 200                 205             


Val Thr Arg Trp Glu Thr Phe Asp Val Ser Pro Ala Val Leu Arg Trp 
    210                 215                 220                 


Thr Arg Glu Lys Gln Pro Asn Tyr Gly Leu Ala Ile Glu Val Thr His 
225                 230                 235                 240 


Leu His Gln Thr Arg Thr His Gln Gly Gln His Val Arg Ile Ser Arg 
                245                 250                 255     


Ser Leu Pro Gln Gly Ser Gly Asn Trp Ala Gln Leu Arg Pro Leu Leu 
            260                 265                 270         


Val Thr Phe Gly His Asp Gly Arg Gly His Ala Leu Thr Arg Arg Arg 
        275                 280                 285             


Arg Ala Lys Arg Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys 
    290                 295                 300                 


Asn Lys Asn Cys Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val 
305                 310                 315                 320 


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr 
                325                 330                 335     


Cys His Gly Asp Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
            340                 345                 350         


Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser Ile 
        355                 360                 365             


Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
    370                 375                 380                 


Tyr Leu Asp Glu Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met 
385                 390                 395                 400 


Val Val Glu Gly Cys Gly Cys Arg 
                405             


<210>  115
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Lys Thr Pro Trp Lys Val Leu Leu Gly Leu Leu Gly Ala Ala Ala 
1               5                   10                  15      


Leu Val Thr Ile Ile Thr Val Pro Val Val Leu Leu Asn Lys Gly Thr 
            20                  25                  30          


Asp Asp Ala Thr Ala Asp Ser Arg Lys Thr Tyr Thr Leu Thr Asp Tyr 
        35                  40                  45              


Leu Lys Asn Thr Tyr Arg Leu Lys Leu Tyr Ser Leu Arg Trp Ile Ser 
    50                  55                  60                  


Asp His Glu Tyr Leu Tyr Lys Gln Glu Asn Asn Ile Leu Val Phe Asn 
65                  70                  75                  80  


Ala Glu Tyr Gly Asn Ser Ser Val Phe Leu Glu Asn Ser Thr Phe Asp 
                85                  90                  95      


Glu Phe Gly His Ser Ile Asn Asp Tyr Ser Ile Ser Pro Asp Gly Gln 
            100                 105                 110         


Phe Ile Leu Leu Glu Tyr Asn Tyr Val Lys Gln Trp Arg His Ser Tyr 
        115                 120                 125             


Thr Ala Ser Tyr Asp Ile Tyr Asp Leu Asn Lys Arg Gln Leu Ile Thr 
    130                 135                 140                 


Glu Glu Arg Ile Pro Asn Asn Thr Gln Trp Val Thr Trp Ser Pro Val 
145                 150                 155                 160 


Gly His Lys Leu Ala Tyr Val Trp Asn Asn Asp Ile Tyr Val Lys Ile 
                165                 170                 175     


Glu Pro Asn Leu Pro Ser Tyr Arg Ile Thr Trp Thr Gly Lys Glu Asp 
            180                 185                 190         


Ile Ile Tyr Asn Gly Ile Thr Asp Trp Val Tyr Glu Glu Glu Val Phe 
        195                 200                 205             


Ser Ala Tyr Ser Ala Leu Trp Trp Ser Pro Asn Gly Thr Phe Leu Ala 
    210                 215                 220                 


Tyr Ala Gln Phe Asn Asp Thr Glu Val Pro Leu Ile Glu Tyr Ser Phe 
225                 230                 235                 240 


Tyr Ser Asp Glu Ser Leu Gln Tyr Pro Lys Thr Val Arg Val Pro Tyr 
                245                 250                 255     


Pro Lys Ala Gly Ala Val Asn Pro Thr Val Lys Phe Phe Val Val Asn 
            260                 265                 270         


Thr Asp Ser Leu Ser Ser Val Thr Asn Ala Thr Ser Ile Gln Ile Thr 
        275                 280                 285             


Ala Pro Ala Ser Met Leu Ile Gly Asp His Tyr Leu Cys Asp Val Thr 
    290                 295                 300                 


Trp Ala Thr Gln Glu Arg Ile Ser Leu Gln Trp Leu Arg Arg Ile Gln 
305                 310                 315                 320 


Asn Tyr Ser Val Met Asp Ile Cys Asp Tyr Asp Glu Ser Ser Gly Arg 
                325                 330                 335     


Trp Asn Cys Leu Val Ala Arg Gln His Ile Glu Met Ser Thr Thr Gly 
            340                 345                 350         


Trp Val Gly Arg Phe Arg Pro Ser Glu Pro His Phe Thr Leu Asp Gly 
        355                 360                 365             


Asn Ser Phe Tyr Lys Ile Ile Ser Asn Glu Glu Gly Tyr Arg His Ile 
    370                 375                 380                 


Cys Tyr Phe Gln Ile Asp Lys Lys Asp Cys Thr Phe Ile Thr Lys Gly 
385                 390                 395                 400 


Thr Trp Glu Val Ile Gly Ile Glu Ala Leu Thr Ser Asp Tyr Leu Tyr 
                405                 410                 415     


Tyr Ile Ser Asn Glu Tyr Lys Gly Met Pro Gly Gly Arg Asn Leu Tyr 
            420                 425                 430         


Lys Ile Gln Leu Ser Asp Tyr Thr Lys Val Thr Cys Leu Ser Cys Glu 
        435                 440                 445             


Leu Asn Pro Glu Arg Cys Gln Tyr Tyr Ser Val Ser Phe Ser Lys Glu 
    450                 455                 460                 


Ala Lys Tyr Tyr Gln Leu Arg Cys Ser Gly Pro Gly Leu Pro Leu Tyr 
465                 470                 475                 480 


Thr Leu His Ser Ser Val Asn Asp Lys Gly Leu Arg Val Leu Glu Asp 
                485                 490                 495     


Asn Ser Ala Leu Asp Lys Met Leu Gln Asn Val Gln Met Pro Ser Lys 
            500                 505                 510         


Lys Leu Asp Phe Ile Ile Leu Asn Glu Thr Lys Phe Trp Tyr Gln Met 
        515                 520                 525             


Ile Leu Pro Pro His Phe Asp Lys Ser Lys Lys Tyr Pro Leu Leu Leu 
    530                 535                 540                 


Asp Val Tyr Ala Gly Pro Cys Ser Gln Lys Ala Asp Thr Val Phe Arg 
545                 550                 555                 560 


Leu Asn Trp Ala Thr Tyr Leu Ala Ser Thr Glu Asn Ile Ile Val Ala 
                565                 570                 575     


Ser Phe Asp Gly Arg Gly Ser Gly Tyr Gln Gly Asp Lys Ile Met His 
            580                 585                 590         


Ala Ile Asn Arg Arg Leu Gly Thr Phe Glu Val Glu Asp Gln Ile Glu 
        595                 600                 605             


Ala Ala Arg Gln Phe Ser Lys Met Gly Phe Val Asp Asn Lys Arg Ile 
    610                 615                 620                 


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Thr Ser Met Val Leu 
625                 630                 635                 640 


Gly Ser Gly Ser Gly Val Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
                645                 650                 655     


Ser Arg Trp Glu Tyr Tyr Asp Ser Val Tyr Thr Glu Arg Tyr Met Gly 
            660                 665                 670         


Leu Pro Thr Pro Glu Asp Asn Leu Asp His Tyr Arg Asn Ser Thr Val 
        675                 680                 685             


Met Ser Arg Ala Glu Asn Phe Lys Gln Val Glu Tyr Leu Leu Ile His 
    690                 695                 700                 


Gly Thr Ala Asp Asp Asn Val His Phe Gln Gln Ser Ala Gln Ile Ser 
705                 710                 715                 720 


Lys Ala Leu Val Asp Val Gly Val Asp Phe Gln Ala Met Trp Tyr Thr 
                725                 730                 735     


Asp Glu Asp His Gly Ile Ala Ser Ser Thr Ala His Gln His Ile Tyr 
            740                 745                 750         


Thr His Met Ser His Phe Ile Lys Gln Cys Phe Ser Leu Pro 
        755                 760                 765     


<210>  116
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Ala Thr Glu Asn Gly Ala Val Glu Leu Gly Ile Gln Asn Pro Ser 
1               5                   10                  15      


Thr Asp Lys Ala Pro Lys Gly Pro Thr Gly Glu Arg Pro Leu Ala Ala 
            20                  25                  30          


Gly Lys Asp Pro Gly Pro Pro Asp Pro Lys Lys Ala Pro Asp Pro Pro 
        35                  40                  45              


Thr Leu Lys Lys Asp Ala Lys Ala Pro Ala Ser Glu Lys Gly Asp Gly 
    50                  55                  60                  


Thr Leu Ala Gln Pro Ser Thr Ser Ser Gln Gly Pro Lys Gly Glu Gly 
65                  70                  75                  80  


Asp Arg Gly Gly Gly Pro Ala Glu Gly Ser Ala Gly Pro Pro Ala Ala 
                85                  90                  95      


Leu Pro Gln Gln Thr Ala Thr Pro Glu Thr Ser Val Lys Lys Pro Lys 
            100                 105                 110         


Ala Glu Gln Gly Ala Ser Gly Ser Gln Asp Pro Gly Lys Pro Arg Val 
        115                 120                 125             


Gly Lys Lys Ala Ala Glu Gly Gln Ala Ala Ala Arg Arg Gly Ser Pro 
    130                 135                 140                 


Ala Phe Leu His Ser Pro Ser Cys Pro Ala Ile Ile Ser Ser Ser Glu 
145                 150                 155                 160 


Lys Leu Leu Ala Lys Lys Pro Pro Ser Glu Ala Ser Glu Leu Thr Phe 
                165                 170                 175     


Glu Gly Val Pro Met Thr His Ser Pro Thr Asp Pro Arg Pro Ala Lys 
            180                 185                 190         


Ala Glu Glu Gly Lys Asn Ile Leu Ala Glu Ser Gln Lys Glu Val Gly 
        195                 200                 205             


Glu Lys Thr Pro Gly Gln Ala Gly Gln Ala Lys Met Gln Gly Asp Thr 
    210                 215                 220                 


Ser Arg Gly Ile Glu Phe Gln Ala Val Pro Ser Glu Lys Ser Glu Val 
225                 230                 235                 240 


Gly Gln Ala Leu Cys Leu Thr Ala Arg Glu Glu Asp Cys Phe Gln Ile 
                245                 250                 255     


Leu Asp Asp Cys Pro Pro Pro Pro Ala Pro Phe Pro His Arg Met Val 
            260                 265                 270         


Glu Leu Arg Thr Gly Asn Val Ser Ser Glu Phe Ser Met Asn Ser Lys 
        275                 280                 285             


Glu Ala Leu Gly Gly Gly Lys Phe Gly Ala Val Cys Thr Cys Met Glu 
    290                 295                 300                 


Lys Ala Thr Gly Leu Lys Leu Ala Ala Lys Val Ile Lys Lys Gln Thr 
305                 310                 315                 320 


Pro Lys Asp Lys Glu Met Val Leu Leu Glu Ile Glu Val Met Asn Gln 
                325                 330                 335     


Leu Asn His Arg Asn Leu Ile Gln Leu Tyr Ala Ala Ile Glu Thr Pro 
            340                 345                 350         


His Glu Ile Val Leu Phe Met Glu Tyr Ile Glu Gly Gly Glu Leu Phe 
        355                 360                 365             


Glu Arg Ile Val Asp Glu Asp Tyr His Leu Thr Glu Val Asp Thr Met 
    370                 375                 380                 


Val Phe Val Arg Gln Ile Cys Asp Gly Ile Leu Phe Met His Lys Met 
385                 390                 395                 400 


Arg Val Leu His Leu Asp Leu Lys Pro Glu Asn Ile Leu Cys Val Asn 
                405                 410                 415     


Thr Thr Gly His Leu Val Lys Ile Ile Asp Phe Gly Leu Ala Arg Arg 
            420                 425                 430         


Tyr Asn Pro Asn Glu Lys Leu Lys Val Asn Phe Gly Thr Pro Glu Phe 
        435                 440                 445             


Leu Ser Pro Glu Val Val Asn Tyr Asp Gln Ile Ser Asp Lys Thr Asp 
    450                 455                 460                 


Met Trp Ser Met Gly Val Ile Thr Tyr Met Leu Leu Ser Gly Leu Ser 
465                 470                 475                 480 


Pro Phe Leu Gly Asp Asp Asp Thr Glu Thr Leu Asn Asn Val Leu Ser 
                485                 490                 495     


Gly Asn Trp Tyr Phe Asp Glu Glu Thr Phe Glu Ala Val Ser Asp Glu 
            500                 505                 510         


Ala Lys Asp Phe Val Ser Asn Leu Ile Val Lys Asp Gln Arg Ala Arg 
        515                 520                 525             


Met Asn Ala Ala Gln Cys Leu Ala His Pro Trp Leu Asn Asn Leu Ala 
    530                 535                 540                 


Glu Lys Ala Lys Arg Cys Asn Arg Arg Leu Lys Ser Gln Ile Leu Leu 
545                 550                 555                 560 


Lys Lys Tyr Leu Met Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val 
                565                 570                 575     


Ser Ala Ala Asn Arg Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu Met 
            580                 585                 590         


Ala Leu Gly Val 
        595     


<210>  117
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Leu Lys Val Lys Arg Leu Glu Glu Phe Asn Thr Cys Tyr Asn Ser 
1               5                   10                  15      


Asn Gln Leu Glu Lys Met Ala Phe Phe Gln Cys Arg Glu Glu Val Glu 
            20                  25                  30          


Lys Val Lys Cys Phe Leu Glu Lys Asn Ser Gly Asp Gln Asp Ser Arg 
        35                  40                  45              


Ser Gly His Asn Glu Ala Lys Glu Val Trp Ser Asn Ala Asp Leu Thr 
    50                  55                  60                  


Glu Arg Met Pro Val Lys Ser Lys Arg Thr Ser Ala Leu Ala Val Asp 
65                  70                  75                  80  


Ile Pro Ala Pro Pro Ala Pro Phe Asp His Arg Ile Val Thr Ala Lys 
                85                  90                  95      


Gln Gly Ala Val Asn Ser Phe Tyr Thr Val Ser Lys Thr Glu Ile Leu 
            100                 105                 110         


Gly Gly Gly Arg Phe Gly Gln Val His Lys Cys Glu Glu Thr Ala Thr 
        115                 120                 125             


Gly Leu Lys Leu Ala Ala Lys Ile Ile Lys Thr Arg Gly Met Lys Asp 
    130                 135                 140                 


Lys Glu Glu Val Lys Asn Glu Ile Ser Val Met Asn Gln Leu Asp His 
145                 150                 155                 160 


Ala Asn Leu Ile Gln Leu Tyr Asp Ala Phe Glu Ser Lys Asn Asp Ile 
                165                 170                 175     


Val Leu Val Met Glu Tyr Val Asp Gly Gly Glu Leu Phe Asp Arg Ile 
            180                 185                 190         


Ile Asp Glu Ser Tyr Asn Leu Thr Glu Leu Asp Thr Ile Leu Phe Met 
        195                 200                 205             


Lys Gln Ile Cys Glu Gly Ile Arg His Met His Gln Met Tyr Ile Leu 
    210                 215                 220                 


His Leu Asp Leu Lys Pro Glu Asn Ile Leu Cys Val Asn Arg Asp Ala 
225                 230                 235                 240 


Lys Gln Ile Lys Ile Ile Asp Phe Gly Leu Ala Arg Arg Tyr Lys Pro 
                245                 250                 255     


Arg Glu Lys Leu Lys Val Asn Phe Gly Thr Pro Glu Phe Leu Ala Pro 
            260                 265                 270         


Glu Val Val Asn Tyr Asp Phe Val Ser Phe Pro Thr Asp Met Trp Ser 
        275                 280                 285             


Val Gly Val Ile Ala Tyr Met Leu Leu Ser Gly Leu Ser Pro Phe Leu 
    290                 295                 300                 


Gly Asp Asn Asp Ala Glu Thr Leu Asn Asn Ile Leu Ala Cys Arg Trp 
305                 310                 315                 320 


Asp Leu Glu Asp Glu Glu Phe Gln Asp Ile Ser Glu Glu Ala Lys Glu 
                325                 330                 335     


Phe Ile Ser Lys Leu Leu Ile Lys Glu Lys Ser Trp Arg Ile Ser Ala 
            340                 345                 350         


Ser Glu Ala Leu Lys His Pro Trp Leu Ser Asp His Lys Leu His Ser 
        355                 360                 365             


Arg Leu Asn Ala Gln Lys Lys Lys Asn Arg Gly Ser Asp Ala Gln Asp 
    370                 375                 380                 


Phe Val Thr Lys 
385             


<210>  118
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Leu Lys Val Lys Arg Leu Glu Glu Phe Asn Thr Cys Tyr Asn Ser 
1               5                   10                  15      


Asn Gln Leu Glu Lys Met Ala Phe Phe Gln Cys Arg Glu Glu Val Glu 
            20                  25                  30          


Lys Val Lys Cys Phe Leu Glu Lys Asn Ser Gly Asp Gln Asp Ser Arg 
        35                  40                  45              


Ser Gly His Asn Glu Ala Lys Glu Val Trp Ser Asn Ala Asp Leu Thr 
    50                  55                  60                  


Glu Arg Met Pro Val Lys Ser Lys Arg Thr Ser Ala Leu Ala Val Asp 
65                  70                  75                  80  


Ile Pro Ala Pro Pro Ala Pro Phe Asp His Arg Ile Val Thr Ala Lys 
                85                  90                  95      


Gln Gly Ala Val Asn Ser Phe Tyr Thr Val Ser Lys Thr Glu Ile Leu 
            100                 105                 110         


Gly Gly Gly Arg Phe Gly Gln Val His Lys Cys Glu Glu Thr Ala Thr 
        115                 120                 125             


Gly Leu Lys Leu Ala Ala Lys Ile Ile Lys Thr Arg Gly Met Lys Asp 
    130                 135                 140                 


Lys Glu Glu Val Lys Asn Glu Ile Ser Val Met Asn Gln Leu Asp His 
145                 150                 155                 160 


Ala Asn Leu Ile Gln Leu Tyr Asp Ala Phe Glu Ser Lys Asn Asp Ile 
                165                 170                 175     


Val Leu Val Met Glu Tyr Val Asp Gly Gly Glu Leu Phe Asp Arg Ile 
            180                 185                 190         


Ile Asp Glu Ser Tyr Asn Leu Thr Glu Leu Asp Thr Ile Leu Phe Met 
        195                 200                 205             


Lys Gln Ile Cys Glu Gly Ile Arg His Met His Gln Met Tyr Ile Leu 
    210                 215                 220                 


His Leu Asp Leu Lys Pro Glu Asn Ile Gln Cys Ser Arg Phe Leu Ile 
225                 230                 235                 240 


Asp Thr Ser Ile Leu Pro Leu Cys Leu Leu Asn Cys Arg Tyr Lys Pro 
                245                 250                 255     


Arg Glu Lys Leu Lys Val Asn Phe Gly Thr Pro Glu Phe Leu Ala Pro 
            260                 265                 270         


Glu Val Val Asn Tyr Asp Phe Val Ser Phe Pro Thr Asp Met Trp Ser 
        275                 280                 285             


Val Gly Val Ile Ala Tyr Met Leu Leu Ser Gly Leu Ser Pro Phe Leu 
    290                 295                 300                 


Gly Asp Asn Asp Ala Glu Thr Leu Asn Asn Ile Leu Ala Cys Arg Trp 
305                 310                 315                 320 


Asp Leu Glu Asp Glu Glu Phe Gln Asp Ile Ser Glu Glu Ala Lys Glu 
                325                 330                 335     


Phe Ile Ser Lys Leu Leu Ile Lys Glu Lys Ser Trp Arg Ile Ser Ala 
            340                 345                 350         


Ser Glu Ala Leu Lys His Pro Trp Leu Ser Asp His Lys Leu His Ser 
        355                 360                 365             


Arg Leu Asn Ala Gln Lys Lys Lys Asn Arg Gly Ser Asp Ala Gln Asp 
    370                 375                 380                 


Phe Val Thr Lys 
385             


<210>  119
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Gly Ala Gly Val Leu Val Leu Gly Ala Ser Glu Pro Gly Asn Leu 
1               5                   10                  15      


Ser Ser Ala Ala Pro Leu Pro Asp Gly Ala Ala Thr Ala Ala Arg Leu 
            20                  25                  30          


Leu Val Pro Ala Ser Pro Pro Ala Ser Leu Leu Pro Pro Ala Ser Glu 
        35                  40                  45              


Ser Pro Glu Pro Leu Ser Gln Gln Trp Thr Ala Gly Met Gly Leu Leu 
    50                  55                  60                  


Met Ala Leu Ile Val Leu Leu Ile Val Ala Gly Asn Val Leu Val Ile 
65                  70                  75                  80  


Val Ala Ile Ala Lys Thr Pro Arg Leu Gln Thr Leu Thr Asn Leu Phe 
                85                  90                  95      


Ile Met Ser Leu Ala Ser Ala Asp Leu Val Met Gly Leu Leu Val Val 
            100                 105                 110         


Pro Phe Gly Ala Thr Ile Val Val Trp Gly Arg Trp Glu Tyr Gly Ser 
        115                 120                 125             


Phe Phe Cys Glu Leu Trp Thr Ser Val Asp Val Leu Cys Val Thr Ala 
    130                 135                 140                 


Ser Ile Glu Thr Leu Cys Val Ile Ala Leu Asp Arg Tyr Leu Ala Ile 
145                 150                 155                 160 


Thr Ser Pro Phe Arg Tyr Gln Ser Leu Leu Thr Arg Ala Arg Ala Arg 
                165                 170                 175     


Gly Leu Val Cys Thr Val Trp Ala Ile Ser Ala Leu Val Ser Phe Leu 
            180                 185                 190         


Pro Ile Leu Met His Trp Trp Arg Ala Glu Ser Asp Glu Ala Arg Arg 
        195                 200                 205             


Cys Tyr Asn Asp Pro Lys Cys Cys Asp Phe Val Thr Asn Arg Ala Tyr 
    210                 215                 220                 


Ala Ile Ala Ser Ser Val Val Ser Phe Tyr Val Pro Leu Cys Ile Met 
225                 230                 235                 240 


Ala Phe Val Tyr Leu Arg Val Phe Arg Glu Ala Gln Lys Gln Val Lys 
                245                 250                 255     


Lys Ile Asp Ser Cys Glu Arg Arg Phe Leu Gly Gly Pro Ala Arg Pro 
            260                 265                 270         


Pro Ser Pro Ser Pro Ser Pro Val Pro Ala Pro Ala Pro Pro Pro Gly 
        275                 280                 285             


Pro Pro Arg Pro Ala Ala Ala Ala Ala Thr Ala Pro Leu Ala Asn Gly 
    290                 295                 300                 


Arg Ala Gly Lys Arg Arg Pro Ser Arg Leu Val Ala Leu Arg Glu Gln 
305                 310                 315                 320 


Lys Ala Leu Lys Thr Leu Gly Ile Ile Met Gly Val Phe Thr Leu Cys 
                325                 330                 335     


Trp Leu Pro Phe Phe Leu Ala Asn Val Val Lys Ala Phe His Arg Glu 
            340                 345                 350         


Leu Val Pro Asp Arg Leu Phe Val Phe Phe Asn Trp Leu Gly Tyr Ala 
        355                 360                 365             


Asn Ser Ala Phe Asn Pro Ile Ile Tyr Cys Arg Ser Pro Asp Phe Arg 
    370                 375                 380                 


Lys Ala Phe Gln Arg Leu Leu Cys Cys Ala Arg Arg Ala Ala Arg Arg 
385                 390                 395                 400 


Arg His Ala Thr His Gly Asp Arg Pro Arg Ala Ser Gly Cys Leu Ala 
                405                 410                 415     


Arg Pro Gly Pro Pro Pro Ser Pro Gly Ala Ala Ser Asp Asp Asp Asp 
            420                 425                 430         


Asp Asp Val Val Gly Ala Thr Pro Pro Ala Arg Leu Leu Glu Pro Trp 
        435                 440                 445             


Ala Gly Cys Asn Gly Gly Ala Ala Ala Asp Ser Asp Ser Ser Leu Asp 
    450                 455                 460                 


Glu Pro Cys Arg Pro Gly Phe Ala Ser Glu Ser Lys Val 
465                 470                 475         


<210>  120
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Thr Ser Ser Lys Ile Glu Met Pro Gly Glu Val Lys Ala Asp Pro 
1               5                   10                  15      


Ala Ala Leu Met Ala Ser Leu His Leu Leu Pro Ser Pro Thr Pro Asn 
            20                  25                  30          


Leu Glu Ile Lys Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp Gln Asn 
        35                  40                  45              


Ser Glu Ser Gly Arg Val Phe Pro Val Tyr Asn Pro Ala Thr Gly Glu 
    50                  55                  60                  


Gln Val Cys Glu Val Gln Glu Ala Asp Lys Ala Asp Ile Asp Lys Ala 
65                  70                  75                  80  


Val Gln Ala Ala Arg Leu Ala Phe Ser Leu Gly Ser Val Trp Arg Arg 
                85                  90                  95      


Met Asp Ala Ser Glu Arg Gly Arg Leu Leu Asp Lys Leu Ala Asp Leu 
            100                 105                 110         


Val Glu Arg Asp Arg Ala Val Leu Ala Thr Met Glu Ser Leu Asn Gly 
        115                 120                 125             


Gly Lys Pro Phe Leu Gln Ala Phe Tyr Val Asp Leu Gln Gly Val Ile 
    130                 135                 140                 


Lys Thr Phe Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Ile His Gly Met 
145                 150                 155                 160 


Thr Ile Pro Val Asp Gly Asp Tyr Phe Thr Phe Thr Arg His Glu Pro 
                165                 170                 175     


Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met 
            180                 185                 190         


Phe Ala Trp Lys Ile Ala Pro Ala Leu Cys Cys Gly Asn Thr Val Val 
        195                 200                 205             


Ile Lys Pro Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Met Gly Ala 
    210                 215                 220                 


Leu Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Ile Asn Ile Leu Pro 
225                 230                 235                 240 


Gly Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ala Ser His Ile Gly Ile 
                245                 250                 255     


Asp Lys Ile Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Gln 
            260                 265                 270         


Glu Ala Ala Gly Arg Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly 
        275                 280                 285             


Gly Lys Ser Pro Asn Ile Ile Phe Ala Asp Ala Asp Leu Asp Tyr Ala 
    290                 295                 300                 


Val Glu Gln Ala His Gln Gly Val Phe Phe Asn Gln Gly Gln Cys Cys 
305                 310                 315                 320 


Thr Ala Gly Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Glu Glu Phe 
                325                 330                 335     


Val Arg Arg Ser Val Glu Arg Ala Lys Arg Arg Val Val Gly Ser Pro 
            340                 345                 350         


Phe Asp Pro Thr Thr Glu Gln Gly Pro Gln Ile Asp Lys Lys Gln Tyr 
        355                 360                 365             


Asn Lys Ile Leu Glu Leu Ile Gln Ser Gly Val Ala Glu Gly Ala Lys 
    370                 375                 380                 


Leu Glu Cys Gly Gly Lys Gly Leu Gly Arg Lys Gly Phe Phe Ile Glu 
385                 390                 395                 400 


Pro Thr Val Phe Ser Asn Val Thr Asp Asp Met Arg Ile Ala Lys Glu 
                405                 410                 415     


Glu Ile Phe Gly Pro Val Gln Glu Ile Leu Arg Phe Lys Thr Met Asp 
            420                 425                 430         


Glu Val Ile Glu Arg Ala Asn Asn Ser Asp Phe Gly Leu Val Ala Ala 
        435                 440                 445             


Val Phe Thr Asn Asp Ile Asn Lys Ala Leu Thr Val Ser Ser Ala Met 
    450                 455                 460                 


Gln Ala Gly Thr Val Trp Ile Asn Cys Tyr Asn Ala Leu Asn Ala Gln 
465                 470                 475                 480 


Ser Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Met Gly 
                485                 490                 495     


Glu Phe Gly Leu Arg Glu Tyr Ser Glu Val Lys Thr Val Thr Val Lys 
            500                 505                 510         


Ile Pro Gln Lys Asn Ser 
        515             


<210>  121
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Thr Ser Ser Lys Ile Glu Met Pro Gly Glu Val Lys Ala Asp Pro 
1               5                   10                  15      


Ala Ala Leu Met Ala Ser Leu His Leu Leu Pro Ser Pro Thr Pro Asn 
            20                  25                  30          


Leu Glu Ile Lys Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp Gln Asn 
        35                  40                  45              


Ser Glu Ser Gly Arg Val Phe Pro Val Tyr Asn Pro Ala Thr Gly Glu 
    50                  55                  60                  


Gln Val Cys Glu Val Gln Glu Ala Asp Lys Ala Asp Ile Asp Lys Ala 
65                  70                  75                  80  


Val Gln Ala Ala Arg Leu Ala Phe Ser Leu Gly Ser Val Trp Arg Arg 
                85                  90                  95      


Met Asp Ala Ser Glu Arg Gly Arg Leu Leu Asp Lys Leu Ala Asp Leu 
            100                 105                 110         


Val Glu Arg Asp Arg Ala Val Leu Ala Thr Met Glu Ser Leu Asn Gly 
        115                 120                 125             


Gly Lys Pro Phe Leu Gln Ala Phe Tyr Val Asp Leu Gln Gly Val Ile 
    130                 135                 140                 


Lys Thr Phe Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Ile His Gly Met 
145                 150                 155                 160 


Thr Ile Pro Val Asp Gly Asp Tyr Phe Thr Phe Thr Arg His Glu Pro 
                165                 170                 175     


Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met 
            180                 185                 190         


Phe Ala Trp Lys Ile Ala Pro Ala Leu Cys Cys Gly Asn Thr Val Val 
        195                 200                 205             


Ile Lys Pro Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Met Gly Ala 
    210                 215                 220                 


Leu Ile Lys Glu Val Gly Lys Leu Ile Gln Glu Ala Ala Gly Arg Ser 
225                 230                 235                 240 


Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Asn Ile 
                245                 250                 255     


Ile Phe Ala Asp Ala Asp Leu Asp Tyr Ala Val Glu Gln Ala His Gln 
            260                 265                 270         


Gly Val Phe Phe Asn Gln Gly Gln Cys Cys Thr Ala Gly Ser Arg Ile 
        275                 280                 285             


Phe Val Glu Glu Ser Ile Tyr Glu Glu Phe Val Arg Arg Ser Val Glu 
    290                 295                 300                 


Arg Ala Lys Arg Arg Val Val Gly Ser Pro Phe Asp Pro Thr Thr Glu 
305                 310                 315                 320 


Gln Gly Pro Gln Ile Asp Lys Lys Gln Tyr Asn Lys Ile Leu Glu Leu 
                325                 330                 335     


Ile Gln Ser Gly Val Ala Glu Gly Ala Lys Leu Glu Cys Gly Gly Lys 
            340                 345                 350         


Gly Leu Gly Arg Lys Gly Phe Phe Ile Glu Pro Thr Val Phe Ser Asn 
        355                 360                 365             


Val Thr Asp Asp Met Arg Ile Ala Lys Glu Glu Ile Phe Gly Pro Val 
    370                 375                 380                 


Gln Glu Ile Leu Arg Phe Lys Thr Met Asp Glu Val Ile Glu Arg Ala 
385                 390                 395                 400 


Asn Asn Ser Asp Phe Gly Leu Val Ala Ala Val Phe Thr Asn Asp Ile 
                405                 410                 415     


Asn Lys Ala Leu Thr Val Ser Ser Ala Met Gln Ala Gly Thr Val Trp 
            420                 425                 430         


Ile Asn Cys Tyr Asn Ala Leu Asn Ala Gln Ser Pro Phe Gly Gly Phe 
        435                 440                 445             


Lys Met Ser Gly Asn Gly Arg Glu Met Gly Glu Phe Gly Leu Arg Glu 
    450                 455                 460                 


Tyr Ser Glu Val Lys Thr Val Thr Val Lys Ile Pro Gln Lys Asn Ser 
465                 470                 475                 480 


<210>  122
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Lys Asn Gln Cys Glu Thr Val Trp Leu Lys Ser Pro Ile Lys Leu 
1               5                   10                  15      


Lys Leu Ile Phe Ile Asn Asn Glu Trp Gln Asn Ser Glu Ser Gly Arg 
            20                  25                  30          


Val Phe Pro Val Tyr Asn Pro Ala Thr Gly Glu Gln Val Cys Glu Val 
        35                  40                  45              


Gln Glu Ala Asp Lys Ala Asp Ile Asp Lys Ala Val Gln Ala Ala Arg 
    50                  55                  60                  


Leu Ala Phe Ser Leu Gly Ser Val Trp Arg Arg Met Asp Ala Ser Glu 
65                  70                  75                  80  


Arg Gly Arg Leu Leu Asp Lys Leu Ala Asp Leu Val Glu Arg Asp Arg 
                85                  90                  95      


Ala Val Leu Ala Thr Met Glu Ser Leu Asn Gly Gly Lys Pro Phe Leu 
            100                 105                 110         


Gln Ala Phe Tyr Val Asp Leu Gln Gly Val Ile Lys Thr Phe Arg Tyr 
        115                 120                 125             


Tyr Ala Gly Trp Ala Asp Lys Ile His Gly Met Thr Ile Pro Val Asp 
    130                 135                 140                 


Gly Asp Tyr Phe Thr Phe Thr Arg His Glu Pro Ile Gly Val Cys Gly 
145                 150                 155                 160 


Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Phe Ala Trp Lys Ile 
                165                 170                 175     


Ala Pro Ala Leu Cys Cys Gly Asn Thr Val Val Ile Lys Pro Ala Glu 
            180                 185                 190         


Gln Thr Pro Leu Ser Ala Leu Tyr Met Gly Ala Leu Ile Lys Glu Ala 
        195                 200                 205             


Gly Phe Pro Pro Gly Val Ile Asn Ile Leu Pro Gly Tyr Gly Pro Thr 
    210                 215                 220                 


Ala Gly Ala Ala Ile Ala Ser His Ile Gly Ile Asp Lys Ile Ala Phe 
225                 230                 235                 240 


Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Gln Glu Ala Ala Gly Arg 
                245                 250                 255     


Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Asn 
            260                 265                 270         


Ile Ile Phe Ala Asp Ala Asp Leu Asp Tyr Ala Val Glu Gln Ala His 
        275                 280                 285             


Gln Gly Val Phe Phe Asn Gln Gly Gln Cys Cys Thr Ala Gly Ser Arg 
    290                 295                 300                 


Ile Phe Val Glu Glu Ser Ile Tyr Glu Glu Phe Val Arg Arg Ser Val 
305                 310                 315                 320 


Glu Arg Ala Lys Arg Arg Val Val Gly Ser Pro Phe Asp Pro Thr Thr 
                325                 330                 335     


Glu Gln Gly Pro Gln Ile Asp Lys Lys Gln Tyr Asn Lys Ile Leu Glu 
            340                 345                 350         


Leu Ile Gln Ser Gly Val Ala Glu Gly Ala Lys Leu Glu Cys Gly Gly 
        355                 360                 365             


Lys Gly Leu Gly Arg Lys Gly Phe Phe Ile Glu Pro Thr Val Phe Ser 
    370                 375                 380                 


Asn Val Thr Asp Asp Met Arg Ile Ala Lys Glu Glu Ile Phe Gly Pro 
385                 390                 395                 400 


Val Gln Glu Ile Leu Arg Phe Lys Thr Met Asp Glu Val Ile Glu Arg 
                405                 410                 415     


Ala Asn Asn Ser Asp Phe Gly Leu Val Ala Ala Val Phe Thr Asn Asp 
            420                 425                 430         


Ile Asn Lys Ala Leu Thr Val Ser Ser Ala Met Gln Ala Gly Thr Val 
        435                 440                 445             


Trp Ile Asn Cys Tyr Asn Ala Leu Asn Ala Gln Ser Pro Phe Gly Gly 
    450                 455                 460                 


Phe Lys Met Ser Gly Asn Gly Arg Glu Met Gly Glu Phe Gly Leu Arg 
465                 470                 475                 480 


Glu Tyr Ser Glu Val Lys Thr Val Thr Val Lys Ile Pro Gln Lys Asn 
                485                 490                 495     


Ser 
    


<210>  123
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Asp Ala Ser Glu Arg Gly Arg Leu Leu Asp Lys Leu Ala Asp Leu 
1               5                   10                  15      


Val Glu Arg Asp Arg Ala Val Leu Ala Thr Met Glu Ser Leu Asn Gly 
            20                  25                  30          


Gly Lys Pro Phe Leu Gln Ala Phe Tyr Val Asp Leu Gln Gly Val Ile 
        35                  40                  45              


Lys Thr Phe Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Ile His Gly Met 
    50                  55                  60                  


Thr Ile Pro Val Asp Gly Asp Tyr Phe Thr Phe Thr Arg His Glu Pro 
65                  70                  75                  80  


Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met 
                85                  90                  95      


Phe Ala Trp Lys Ile Ala Pro Ala Leu Cys Cys Gly Asn Thr Val Val 
            100                 105                 110         


Ile Lys Pro Ala Glu Gln Thr Pro Leu Ser Ala Leu Tyr Met Gly Ala 
        115                 120                 125             


Leu Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Ile Asn Ile Leu Pro 
    130                 135                 140                 


Gly Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ala Ser His Ile Gly Ile 
145                 150                 155                 160 


Asp Lys Ile Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Gln 
                165                 170                 175     


Glu Ala Ala Gly Arg Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly 
            180                 185                 190         


Gly Lys Ser Pro Asn Ile Ile Phe Ala Asp Ala Asp Leu Asp Tyr Ala 
        195                 200                 205             


Val Glu Gln Ala His Gln Gly Val Phe Phe Asn Gln Gly Gln Cys Cys 
    210                 215                 220                 


Thr Ala Gly Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Glu Glu Phe 
225                 230                 235                 240 


Val Arg Arg Ser Val Glu Arg Ala Lys Arg Arg Val Val Gly Ser Pro 
                245                 250                 255     


Phe Asp Pro Thr Thr Glu Gln Gly Pro Gln Ile Asp Lys Lys Gln Tyr 
            260                 265                 270         


Asn Lys Ile Leu Glu Leu Ile Gln Ser Gly Val Ala Glu Gly Ala Lys 
        275                 280                 285             


Leu Glu Cys Gly Gly Lys Gly Leu Gly Arg Lys Gly Phe Phe Ile Glu 
    290                 295                 300                 


Pro Thr Val Phe Ser Asn Val Thr Asp Asp Met Arg Ile Ala Lys Glu 
305                 310                 315                 320 


Glu Ile Phe Gly Pro Val Gln Glu Ile Leu Arg Phe Lys Thr Met Asp 
                325                 330                 335     


Glu Val Ile Glu Arg Ala Asn Asn Ser Asp Phe Gly Leu Val Ala Ala 
            340                 345                 350         


Val Phe Thr Asn Asp Ile Asn Lys Ala Leu Thr Val Ser Ser Ala Met 
        355                 360                 365             


Gln Ala Gly Thr Val Trp Ile Asn Cys Tyr Asn Ala Leu Asn Ala Gln 
    370                 375                 380                 


Ser Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Met Gly 
385                 390                 395                 400 


Glu Phe Gly Leu Arg Glu Tyr Ser Glu Val Lys Thr Val Thr Val Lys 
                405                 410                 415     


Ile Pro Gln Lys Asn Ser 
            420         


<210>  124
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Met Arg Gln Ala Thr Met Asp Phe Ser Thr Pro Ser Val Phe Asp 
1               5                   10                  15      


Gln Gln Arg Gly Asp Ser Ser Glu Glu Val Asp Leu Thr Met Val Tyr 
            20                  25                  30          


Gln Ala Ala Ser Asn Gly Asp Val Asn Ala Leu Thr Ala Val Ile Arg 
        35                  40                  45              


Glu Asp Pro Ser Ile Leu Glu Cys Cys Asp Ser Glu Gly Cys Thr Pro 
    50                  55                  60                  


Leu Met His Ala Val Ser Gly Arg Gln Ala Asp Thr Val Lys Leu Leu 
65                  70                  75                  80  


Leu Lys Met Gly Ala Asn Ile Asn Met Gln Asp Ala Tyr Gly Arg Thr 
                85                  90                  95      


Ser Leu Cys Leu Ala Thr Tyr Leu Gly Trp Leu Glu Gly Cys Val Ser 
            100                 105                 110         


Leu Leu Arg Asn Gly Ala Lys His Asn Ile Pro Asp Lys Asn Gly Arg 
        115                 120                 125             


Leu Pro Leu His Ala Ala Thr Ala Glu Pro Asp Met Arg Leu Leu Thr 
    130                 135                 140                 


Val Leu Leu Gln Gln Ser Asn Ile Ser Glu Ile Asn His Gln Asp Asn 
145                 150                 155                 160 


Glu Gly Met Thr Pro Leu His Trp Ala Ala Phe His Asn Gln Pro Gln 
                165                 170                 175     


His Thr Gln Met Leu Leu Lys Lys Gly Ala Asp Pro Thr Leu Val Asp 
            180                 185                 190         


Lys Asp Phe Lys Thr Ala Leu His Trp Ala Val Gln Ser Gly Asn Arg 
        195                 200                 205             


Ile Leu Cys Ser Ile Ile Leu Ser His His Gln Gly Pro Ser Ile Ile 
    210                 215                 220                 


Asn Tyr Asp Asp Glu Ser Gly Lys Thr Cys Val His Ile Ala Ala Ala 
225                 230                 235                 240 


Ala Gly Phe Ser Asp Ile Ile His Glu Leu Ala Arg Val Pro Glu Cys 
                245                 250                 255     


Asn Leu Gln Ala Leu Asp Val Asp Asp Arg Thr Pro Leu His Trp Ala 
            260                 265                 270         


Ala Ala Ala Gly Lys Ala Glu Cys Val Gln Ser Leu Leu Glu Leu Gly 
        275                 280                 285             


Met Asp Ser Asn Leu Arg Asp Ile Asn Glu Ser Thr Pro Leu Ala Tyr 
    290                 295                 300                 


Ala Leu Tyr Cys Gly His Thr Ala Cys Val Lys Leu Leu Ser Gln Glu 
305                 310                 315                 320 


Ser Arg Thr Glu Pro Thr Arg Pro Pro Pro Ser Gln Ser Ser Arg Pro 
                325                 330                 335     


Gln Lys Lys Glu Arg Arg Phe Asn Val Leu Asn Gln Ile Phe Cys Lys 
            340                 345                 350         


Asn Lys Lys Glu Glu Gln Arg Ala His Gln Lys Asp Pro Ser Arg Asp 
        355                 360                 365             


Arg Tyr Arg Glu Glu Asp Thr Ser Glu Val Asn Asp Ile Ile Thr Thr 
    370                 375                 380                 


Phe Asp Ser Ile Val Gly Thr Asn Cys Gln Glu Gln Pro Gly Asp Gln 
385                 390                 395                 400 


Val Ala Met Val Glu Phe Lys Lys Lys Thr Ser Asp Asn Ser Lys Tyr 
                405                 410                 415     


Leu Leu Pro Glu Lys Lys Pro Leu Ala Arg Lys Gly Leu Pro Pro Ile 
            420                 425                 430         


Arg Thr Gln Ser Leu Pro Pro Ile Thr Leu Gly Asn Asn Phe Leu Thr 
        435                 440                 445             


Ala Ser His Arg Ala Thr Ser His Ala Gly Leu Ser Ser Ala Pro His 
    450                 455                 460                 


His Met Ala Gln Arg Ser Gln Lys Ser Arg Ser Glu Gln Asp Leu Leu 
465                 470                 475                 480 


Asn Asn Arg Thr Gly Cys Gln Met Leu Leu Asp Asn Pro Trp Lys Ser 
                485                 490                 495     


Asp Ser Asn Gln Val Phe Ser Tyr Lys Val Trp Thr Val Ser Ser Ser 
            500                 505                 510         


Asp Lys Leu Leu Asp Arg Leu Leu Ser Val Arg Pro Gly His Gln Glu 
        515                 520                 525             


Val Ser Val Pro Pro His Leu Arg His Leu His Asn Pro Ser Ser Gly 
    530                 535                 540                 


Gln Asn Phe Gln His Leu Ser Pro Asn Arg His Lys Ile Arg Asp Leu 
545                 550                 555                 560 


Pro Phe Thr Arg Asn Asn Leu Ala Pro Leu Pro Asp Gln Lys Phe Leu 
                565                 570                 575     


Ser Gly Glu Pro Leu Arg Thr Asn Arg Val Leu Pro Ala Ile Pro Ser 
            580                 585                 590         


Gln Arg Arg His Ser Thr Ala Ala Glu Glu Ser Glu His Ser Ala Asn 
        595                 600                 605             


Pro Thr Ser Asp Glu Asn 
    610                 


<210>  125
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Asp Ser Asn Leu Arg Asp Ile Asn Glu Ser Thr Pro Leu Ala Tyr 
1               5                   10                  15      


Ala Leu Tyr Cys Gly His Thr Ala Cys Val Lys Leu Leu Ser Gln Glu 
            20                  25                  30          


Ser Arg Thr Glu Pro Thr Arg Pro Pro Pro Ser Gln Ser Ser Arg Pro 
        35                  40                  45              


Gln Lys Lys Glu Arg Arg Phe Asn Val Leu Asn Gln Ile Phe Cys Lys 
    50                  55                  60                  


Asn Lys Lys Glu Glu Gln Arg Ala His Gln Lys Asp Pro Ser Arg Asp 
65                  70                  75                  80  


Arg Tyr Arg Glu Glu Asp Thr Ser Glu Val Asn Asp Ile Ile Thr Thr 
                85                  90                  95      


Phe Asp Ser Ile Val Gly Thr Asn Cys Gln Glu Gln Pro Gly Asp Gln 
            100                 105                 110         


Val Ala Met Val Glu Phe Lys Lys Lys Thr Ser Asp Asn Ser Lys Tyr 
        115                 120                 125             


Leu Leu Pro Glu Lys Lys Pro Leu Ala Arg Lys Gly Leu Pro Pro Ile 
    130                 135                 140                 


Arg Thr Gln Ser Leu Pro Pro Ile Thr Leu Gly Asn Asn Phe Leu Thr 
145                 150                 155                 160 


Ala Ser His Arg Ala Thr Ser His Ala Gly Leu Ser Ser Ala Pro His 
                165                 170                 175     


His Met Ala Gln Arg Ser Gln Lys Ser Arg Ser Glu Gln Asp Leu Leu 
            180                 185                 190         


Asn Asn Arg Thr Gly Cys Gln Met Leu Leu Asp Asn Pro Trp Lys Ser 
        195                 200                 205             


Asp Ser Asn Gln Val Phe Ser Tyr Lys Val Trp Thr Val Ser Ser Ser 
    210                 215                 220                 


Asp Lys Leu Leu Asp Arg Leu Leu Ser Val Arg Pro Gly His Gln Glu 
225                 230                 235                 240 


Val Ser Val Pro Pro His Leu Arg His Leu His Asn Pro Ser Ser Gly 
                245                 250                 255     


Gln Asn Phe Gln His Leu Ser Pro Asn Arg His Lys Ile Arg Asp Leu 
            260                 265                 270         


Pro Phe Thr Arg Asn Asn Leu Ala Pro Leu Pro Asp Gln Lys Phe Leu 
        275                 280                 285             


Ser Gly Glu Pro Leu Arg Thr Asn Arg Val Leu Pro Ala Ile Pro Ser 
    290                 295                 300                 


Gln Arg Arg His Ser Thr Ala Ala Glu Glu Ser Glu His Ser Ala Asn 
305                 310                 315                 320 


Pro Thr Ser Asp Glu Asn 
                325     


<210>  126
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Leu Arg Thr Glu Pro Thr Arg Pro Pro Pro Ser Gln Ser Ser Arg 
1               5                   10                  15      


Pro Gln Lys Lys Glu Arg Arg Phe Asn Val Leu Asn Gln Ile Phe Cys 
            20                  25                  30          


Lys Asn Lys Lys Glu Glu Gln Arg Ala His Gln Lys Asp Pro Ser Arg 
        35                  40                  45              


Asp Arg Tyr Arg Glu Glu Asp Thr Ser Glu Val Asn Asp Ile Ile Thr 
    50                  55                  60                  


Thr Phe Asp Ser Ile Val Gly Thr Asn Cys Gln Glu Gln Pro Gly Asp 
65                  70                  75                  80  


Gln Val Ala Met Val Glu Phe Lys Lys Lys Thr Ser Asp Asn Ser Lys 
                85                  90                  95      


Tyr Leu Leu Pro Glu Lys Lys Pro Leu Ala Arg Lys Gly Leu Pro Pro 
            100                 105                 110         


Ile Arg Thr Gln Ser Leu Pro Pro Ile Thr Leu Gly Asn Asn Phe Leu 
        115                 120                 125             


Thr Ala Ser His Arg Ala Thr Ser His Ala Gly Leu Ser Ser Ala Pro 
    130                 135                 140                 


His His Met Ala Gln Arg Ser Gln Lys Ser Arg Ser Glu Gln Asp Leu 
145                 150                 155                 160 


Leu Asn Asn Arg Thr Gly Cys Gln Met Leu Leu Asp Asn Pro Trp Lys 
                165                 170                 175     


Ser Asp Ser Asn Gln Val Phe Ser Tyr Lys Val Trp Thr Val Ser Ser 
            180                 185                 190         


Ser Asp Lys Leu Leu Asp Arg Leu Leu Ser Val Arg Pro Gly His Gln 
        195                 200                 205             


Glu Val Ser Val Pro Pro His Leu Arg His Leu His Asn Pro Ser Ser 
    210                 215                 220                 


Gly Gln Asn Phe Gln His Leu Ser Pro Asn Arg His Lys Ile Arg Asp 
225                 230                 235                 240 


Leu Pro Phe Thr Arg Asn Asn Leu Ala Pro Leu Pro Asp Gln Lys Phe 
                245                 250                 255     


Leu Ser Gly Glu Pro Leu Arg Thr Asn Arg Val Leu Pro Ala Ile Pro 
            260                 265                 270         


Ser Gln Arg Arg His Ser Thr Ala Ala Glu Glu Ser Glu His Ser Ala 
        275                 280                 285             


Asn Pro Thr Ser Asp Glu Asn 
    290                 295 


<210>  127
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu 
    


<210>  128
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Gln Val Cys Ser Gln Pro Gln Arg Gly Cys Val Arg Glu Gln Ser 
1               5                   10                  15      


Ala Ile Asn Thr Ala Pro Pro Ser Ala His Asn Ala Ala Ser Pro Gly 
            20                  25                  30          


Gly Ala Arg Gly His Arg Val Pro Leu Thr Glu Ala Cys Lys Asp Ser 
        35                  40                  45              


Arg Ile Gly Gly Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu 
    50                  55                  60                  


Leu Thr Trp Glu Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp 
65                  70                  75                  80  


Asn Glu Leu Gln Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys 
                85                  90                  95      


Glu Ile Gln Asn Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile 
            100                 105                 110         


Glu Lys Thr Asn Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu 
        115                 120                 125             


Ala Lys Lys Lys Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu 
    130                 135                 140                 


Thr Lys Leu Lys Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala 
145                 150                 155                 160 


Leu Trp Glu Glu Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe 
                165                 170                 175     


Tyr Ala Arg Val Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu 
            180                 185                 190         


Glu Glu Phe Leu Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly 
        195                 200                 205             


Asp Arg Ile Asp Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met 
    210                 215                 220                 


Leu Asp Val Met Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp 
225                 230                 235                 240 


Glu Leu Phe Gln Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr 
                245                 250                 255     


His Tyr Leu Pro Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe 
            260                 265                 270         


Pro Lys Ser Arg Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu 
        275                 280                 285             


Pro Leu Asn Phe His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His 
    290                 295                 300                 


Glu Ala Gln Gln Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln 
305                 310                 315                 320 


His Pro Pro Thr Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val 
                325                 330                 335     


Cys Arg Glu Ile Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp 
            340                 345                 350         


Gln Cys Asp Lys Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn 
        355                 360                 365             


Asn Pro Ser Gln Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln 
    370                 375                 380                 


Val Ala Glu Arg Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr 
385                 390                 395                 400 


Gln Trp Lys Met Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu 
                405                 410                 415     


Gln Phe Asn Trp Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp 
            420                 425                 430         


Gln Tyr Tyr Leu Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser 
        435                 440                 445             


Asp Val Pro Ser Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser 
    450                 455                 460                 


Asp Pro Ile Thr Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro 
465                 470                 475                 480 


Lys Phe Met Glu Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys 
                485                 490                 495     


Lys His Arg Glu Glu 
            500     


<210>  129
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe 
1               5                   10                  15      


Gln Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu 
            20                  25                  30          


Pro Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser 
        35                  40                  45              


Arg Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn 
    50                  55                  60                  


Phe His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln 
65                  70                  75                  80  


Gln Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro 
                85                  90                  95      


Thr Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu 
            100                 105                 110         


Ile Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp 
        115                 120                 125             


Lys Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser 
    130                 135                 140                 


Gln Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu 
145                 150                 155                 160 


Arg Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys 
                165                 170                 175     


Met Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn 
            180                 185                 190         


Trp Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr 
        195                 200                 205             


Leu Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro 
    210                 215                 220                 


Ser Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile 
225                 230                 235                 240 


Thr Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met 
                245                 250                 255     


Glu Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg 
            260                 265                 270         


Glu Glu 
        


<210>  130
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn Ala 
1               5                   10                  15      


Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn Glu 
            20                  25                  30          


Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys Lys 
        35                  40                  45              


Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys Glu 
    50                  55                  60                  


Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu Cys 
65                  70                  75                  80  


Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val Cys 
                85                  90                  95      


Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn 
            100                 105                 110         


Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser 
        115                 120                 125             


Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met Gln 
    130                 135                 140                 


Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln Asp 
145                 150                 155                 160 


Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe 
                165                 170                 175     


Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg Ile 
            180                 185                 190         


Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe His 
        195                 200                 205             


Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln Ala 
    210                 215                 220                 


Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr Glu 
225                 230                 235                 240 


Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile Arg 
                245                 250                 255     


His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys Cys 
            260                 265                 270         


Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln Ala 
        275                 280                 285             


Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg Leu 
    290                 295                 300                 


Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met Leu 
305                 310                 315                 320 


Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp Val 
                325                 330                 335     


Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu Arg 
            340                 345                 350         


Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser Gly 
        355                 360                 365             


Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr Val 
    370                 375                 380                 


Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu Thr 
385                 390                 395                 400 


Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu Glu 
                405                 410                 415     


<210>  131
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Glu Ala Cys Lys Asp Ser Arg Ile Gly Gly Met Met Lys Thr Leu 
1               5                   10                  15      


Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu Ser Gly Gln Val Leu 
            20                  25                  30          


Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln Glu Met Ser Asn Gln 
        35                  40                  45              


Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn Ala Val Asn Gly Val 
    50                  55                  60                  


Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn Glu Glu Arg Lys Thr 
65                  70                  75                  80  


Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys Lys Glu Asp Ala Leu 
                85                  90                  95      


Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys Glu Leu Pro Gly Val 
            100                 105                 110         


Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu Cys Lys Pro Cys Leu 
        115                 120                 125             


Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val Cys Arg Ser Gly Ser 
    130                 135                 140                 


Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu Asn 
                165                 170                 175     


Asp Arg Gln Gln Thr His Met Leu Asp Val Met Gln Asp His Phe Ser 
            180                 185                 190         


Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe Thr 
        195                 200                 205             


Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe Ser Leu Pro His 
    210                 215                 220                 


Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg Ile Val Arg Ser Leu 
225                 230                 235                 240 


Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe His Ala Met Phe Gln 
                245                 250                 255     


Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln Ala Met Asp Ile His 
            260                 265                 270         


Phe His Ser Pro Ala Phe Gln His Pro Pro Thr Glu Phe Ile Arg Glu 
        275                 280                 285             


Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile Arg His Asn Ser Thr 
    290                 295                 300                 


Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys Cys Arg Glu Ile Leu 
305                 310                 315                 320 


Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln Ala Lys Leu Arg Arg 
                325                 330                 335     


Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg Leu Thr Arg Lys Tyr 
            340                 345                 350         


Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met Leu Asn Thr Ser Ser 
        355                 360                 365             


Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp Val Ser Arg Leu Ala 
    370                 375                 380                 


Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu Arg Val Thr Thr Val 
385                 390                 395                 400 


Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser Gly Val Thr Glu Val 
                405                 410                 415     


Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr Val Thr Val Pro Val 
            420                 425                 430         


Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu Thr Val Ala Glu Lys 
        435                 440                 445             


Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu Glu 
    450                 455                 460 


<210>  132
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln Glu Met Ser Asn 
1               5                   10                  15      


Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn Ala Val Asn Gly 
            20                  25                  30          


Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn Glu Glu Arg Lys 
        35                  40                  45              


Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys Lys Glu Asp Ala 
    50                  55                  60                  


Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys Glu Leu Pro Gly 
65                  70                  75                  80  


Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu Cys Lys Pro Cys 
                85                  90                  95      


Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val Cys Arg Ser Gly 
            100                 105                 110         


Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu Asn Gln Ser Ser 
        115                 120                 125             


Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp Ser Leu Leu Glu 
    130                 135                 140                 


Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met Gln Asp His Phe 
145                 150                 155                 160 


Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln Asp Arg Phe Phe 
                165                 170                 175     


Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro Phe Ser Leu Pro 
            180                 185                 190         


His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg Ile Val Arg Ser 
        195                 200                 205             


Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe His Ala Met Phe 
    210                 215                 220                 


Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln Ala Met Asp Ile 
225                 230                 235                 240 


His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr Glu Phe Ile Arg 
                245                 250                 255     


Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile Arg His Asn Ser 
            260                 265                 270         


Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys Cys Arg Glu Ile 
        275                 280                 285             


Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln Ala Lys Leu Arg 
    290                 295                 300                 


Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg Leu Thr Arg Lys 
305                 310                 315                 320 


Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met Leu Asn Thr Ser 
                325                 330                 335     


Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp Val Ser Arg Leu 
            340                 345                 350         


Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu Arg Val Thr Thr 
        355                 360                 365             


Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser Gly Val Thr Glu 
    370                 375                 380                 


Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr Val Thr Val Pro 
385                 390                 395                 400 


Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu Thr Val Ala Glu 
                405                 410                 415     


Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu Glu 
            420                 425                 


<210>  133
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Asp Gly Pro Ala Ile Ile Thr Gln Val Thr Asn Pro Lys Glu Asp 
1               5                   10                  15      


Glu Gly Arg Leu Pro Gly Ala Gly Glu Lys Ala Ser Gln Cys Asn Val 
            20                  25                  30          


Ser Leu Lys Lys Gln Arg Ser Arg Ser Ile Leu Ser Ser Phe Phe Cys 
        35                  40                  45              


Cys Phe Arg Asp Tyr Asn Val Glu Ala Pro Pro Pro Ser Ser Pro Ser 
    50                  55                  60                  


Val Leu Pro Pro Leu Val Glu Glu Asn Gly Gly Leu Gln Lys Gly Asp 
65                  70                  75                  80  


Gln Arg Gln Val Ile Pro Ile Pro Ser Pro Pro Ala Lys Tyr Leu Leu 
                85                  90                  95      


Pro Glu Val Thr Val Leu Asp Tyr Gly Lys Lys Cys Val Val Ile Asp 
            100                 105                 110         


Leu Asp Glu Thr Leu Val His Ser Ser Phe Lys Pro Ile Ser Asn Ala 
        115                 120                 125             


Asp Phe Ile Val Pro Val Glu Ile Asp Gly Thr Ile His Gln Val Tyr 
    130                 135                 140                 


Val Leu Lys Arg Pro His Val Asp Glu Phe Leu Gln Arg Met Gly Gln 
145                 150                 155                 160 


Leu Phe Glu Cys Val Leu Phe Thr Ala Ser Leu Ala Lys Tyr Ala Asp 
                165                 170                 175     


Pro Val Ala Asp Leu Leu Asp Arg Trp Gly Val Phe Arg Ala Arg Leu 
            180                 185                 190         


Phe Arg Glu Ser Cys Val Phe His Arg Gly Asn Tyr Val Lys Asp Leu 
        195                 200                 205             


Ser Arg Leu Gly Arg Glu Leu Ser Lys Val Ile Ile Val Asp Asn Ser 
    210                 215                 220                 


Pro Ala Ser Tyr Ile Phe His Pro Glu Asn Ala Val Pro Val Gln Ser 
225                 230                 235                 240 


Trp Phe Asp Asp Met Thr Asp Thr Glu Leu Leu Asp Leu Ile Pro Phe 
                245                 250                 255     


Phe Glu Gly Leu Ser Arg Glu Asp Asp Val Tyr Ser Met Leu His Arg 
            260                 265                 270         


Leu Cys Asn Arg 
        275     


<210>  134
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Asp Gly Pro Ala Ile Ile Thr Gln Val Thr Asn Pro Lys Glu Asp 
1               5                   10                  15      


Glu Gly Arg Leu Pro Gly Ala Gly Glu Lys Ala Ser Gln Cys Asn Val 
            20                  25                  30          


Ser Leu Lys Lys Gln Arg Ser Arg Ser Ile Leu Ser Ser Phe Phe Cys 
        35                  40                  45              


Cys Phe Arg Asp Tyr Asn Val Glu Ala Pro Pro Pro Ser Ser Pro Ser 
    50                  55                  60                  


Val Leu Pro Pro Leu Val Glu Glu Asn Gly Gly Leu Gln Lys Pro Pro 
65                  70                  75                  80  


Ala Lys Tyr Leu Leu Pro Glu Val Thr Val Leu Asp Tyr Gly Lys Lys 
                85                  90                  95      


Cys Val Val Ile Asp Leu Asp Glu Thr Leu Val His Ser Ser Phe Lys 
            100                 105                 110         


Pro Ile Ser Asn Ala Asp Phe Ile Val Pro Val Glu Ile Asp Gly Thr 
        115                 120                 125             


Ile His Gln Val Tyr Val Leu Lys Arg Pro His Val Asp Glu Phe Leu 
    130                 135                 140                 


Gln Arg Met Gly Gln Leu Phe Glu Cys Val Leu Phe Thr Ala Ser Leu 
145                 150                 155                 160 


Ala Lys Tyr Ala Asp Pro Val Ala Asp Leu Leu Asp Arg Trp Gly Val 
                165                 170                 175     


Phe Arg Ala Arg Leu Phe Arg Glu Ser Cys Val Phe His Arg Gly Asn 
            180                 185                 190         


Tyr Val Lys Asp Leu Ser Arg Leu Gly Arg Glu Leu Ser Lys Val Ile 
        195                 200                 205             


Ile Val Asp Asn Ser Pro Ala Ser Tyr Ile Phe His Pro Glu Asn Ala 
    210                 215                 220                 


Val Pro Val Gln Ser Trp Phe Asp Asp Met Thr Asp Thr Glu Leu Leu 
225                 230                 235                 240 


Asp Leu Ile Pro Phe Phe Glu Gly Leu Ser Arg Glu Asp Asp Val Tyr 
                245                 250                 255     


Ser Met Leu His Arg Leu Cys Asn Arg 
            260                 265 


<210>  135
<211>  734
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Ala Ala Ser Pro Gly Pro Ala Gly Val Gly Gly Ala Gly Ala Val 
1               5                   10                  15      


Tyr Gly Ser Gly Ser Ser Gly Phe Ala Leu Asp Ser Gly Leu Glu Ile 
            20                  25                  30          


Lys Thr Arg Ser Val Glu Gln Thr Leu Leu Pro Leu Val Ser Gln Ile 
        35                  40                  45              


Thr Thr Leu Ile Asn His Lys Asp Asn Thr Lys Lys Ser Asp Lys Thr 
    50                  55                  60                  


Leu Gln Ala Ile Gln Arg Val Gly Gln Ala Val Asn Leu Ala Val Gly 
65                  70                  75                  80  


Arg Phe Val Lys Val Gly Glu Ala Ile Ala Asn Glu Asn Trp Asp Leu 
                85                  90                  95      


Lys Glu Glu Ile Asn Ile Ala Cys Ile Glu Ala Lys Gln Ala Gly Glu 
            100                 105                 110         


Thr Ile Ala Ala Leu Thr Asp Ile Thr Asn Leu Asn His Leu Glu Ser 
        115                 120                 125             


Asp Gly Gln Ile Thr Ile Phe Thr Asp Lys Thr Gly Val Ile Lys Ala 
    130                 135                 140                 


Ala Arg Leu Leu Leu Ser Ser Val Thr Lys Val Leu Leu Leu Ala Asp 
145                 150                 155                 160 


Arg Val Val Ile Lys Gln Ile Ile Thr Ser Arg Asn Lys Val Leu Ala 
                165                 170                 175     


Thr Met Glu Arg Leu Glu Lys Val Asn Ser Phe Gln Glu Phe Val Gln 
            180                 185                 190         


Ile Phe Ser Gln Phe Gly Asn Glu Met Val Glu Phe Ala His Leu Ser 
        195                 200                 205             


Gly Asp Arg Gln Asn Asp Leu Lys Asp Glu Lys Lys Lys Ala Lys Met 
    210                 215                 220                 


Ala Ala Ala Arg Ala Val Leu Glu Lys Cys Thr Met Met Leu Leu Thr 
225                 230                 235                 240 


Ala Ser Lys Thr Cys Leu Arg His Pro Asn Cys Glu Ser Ala His Lys 
                245                 250                 255     


Asn Lys Glu Gly Val Phe Asp Arg Met Lys Val Ala Leu Asp Lys Val 
            260                 265                 270         


Ile Glu Ile Val Thr Asp Cys Lys Pro Asn Gly Glu Thr Asp Ile Ser 
        275                 280                 285             


Ser Ile Ser Ile Phe Thr Gly Ile Lys Glu Phe Lys Met Asn Ile Glu 
    290                 295                 300                 


Ala Leu Arg Glu Asn Leu Tyr Phe Gln Ser Lys Glu Asn Leu Ser Val 
305                 310                 315                 320 


Thr Leu Glu Val Ile Leu Glu Arg Met Glu Asp Phe Thr Asp Ser Ala 
                325                 330                 335     


Tyr Thr Ser His Glu His Arg Glu Arg Ile Leu Glu Leu Ser Thr Gln 
            340                 345                 350         


Ala Arg Met Glu Leu Gln Gln Leu Ile Ser Val Trp Ile Gln Ala Gln 
        355                 360                 365             


Ser Lys Lys Thr Lys Ser Ile Ala Glu Glu Leu Glu Leu Ser Ile Leu 
    370                 375                 380                 


Lys Ile Ser His Ser Leu Asn Glu Leu Lys Lys Glu Leu His Ser Thr 
385                 390                 395                 400 


Ala Thr Gln Leu Ala Ala Asp Leu Leu Lys Tyr His Ala Asp His Val 
                405                 410                 415     


Val Leu Lys Ala Leu Lys Leu Thr Gly Val Glu Gly Asn Leu Glu Ala 
            420                 425                 430         


Leu Ala Glu Tyr Ala Cys Lys Leu Ser Glu Gln Lys Glu Gln Leu Val 
        435                 440                 445             


Glu Thr Cys Arg Leu Leu Arg His Ile Ser Gly Thr Glu Pro Leu Glu 
    450                 455                 460                 


Ile Thr Cys Ile His Ala Glu Glu Thr Phe Gln Val Thr Gly Gln Gln 
465                 470                 475                 480 


Ile Ile Ser Ala Ala Glu Thr Leu Thr Leu His Pro Ser Ser Lys Ile 
                485                 490                 495     


Ala Lys Glu Asn Leu Asp Val Phe Cys Glu Ala Trp Glu Ser Gln Ile 
            500                 505                 510         


Ser Asp Met Ser Thr Leu Leu Arg Glu Ile Asn Asp Val Phe Glu Gly 
        515                 520                 525             


Arg Arg Gly Glu Lys Tyr Gly Tyr Leu Ser Leu Pro Lys Pro Met Lys 
    530                 535                 540                 


Asn Asn Ala Asn Leu Lys Ser Leu Lys Pro Asp Lys Pro Asp Ser Glu 
545                 550                 555                 560 


Glu Gln Ala Lys Ile Ala Lys Leu Gly Leu Lys Leu Gly Leu Leu Thr 
                565                 570                 575     


Ser Asp Ala Asp Cys Glu Ile Glu Lys Trp Glu Asp Gln Glu Asn Glu 
            580                 585                 590         


Ile Val Gln Tyr Gly Arg Asn Met Ser Ser Met Ala Tyr Ser Leu Tyr 
        595                 600                 605             


Leu Phe Thr Arg Gly Glu Gly Pro Leu Lys Thr Ser Gln Asp Leu Ile 
    610                 615                 620                 


His Gln Leu Glu Val Phe Ala Ala Glu Gly Leu Lys Leu Thr Ser Ser 
625                 630                 635                 640 


Val Gln Ala Phe Ser Lys Gln Leu Lys Asp Asp Asp Lys Leu Met Leu 
                645                 650                 655     


Leu Leu Glu Ile Asn Lys Leu Ile Pro Leu Cys His Gln Leu Gln Thr 
            660                 665                 670         


Val Thr Lys Thr Ser Leu Gln Asn Lys Val Phe Leu Lys Val Asp Lys 
        675                 680                 685             


Cys Ile Thr Lys Thr Arg Ser Met Met Ala Leu Leu Val Gln Leu Leu 
    690                 695                 700                 


Ser Leu Cys Tyr Lys Leu Leu Lys Lys Leu Gln Met Glu Asn Asn Gly 
705                 710                 715                 720 


Trp Val Ser Val Thr Asn Lys Asp Thr Met Asp Ser Lys Thr 
                725                 730                 


<210>  136
<211>  718
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Ala Ala Ser Pro Gly Pro Ala Gly Val Gly Gly Ala Gly Ala Val 
1               5                   10                  15      


Tyr Gly Ser Gly Ser Ser Gly Phe Ala Leu Asp Ser Gly Leu Glu Ile 
            20                  25                  30          


Lys Thr Arg Ser Val Glu Gln Thr Leu Leu Pro Leu Val Ser Gln Ile 
        35                  40                  45              


Thr Thr Leu Ile Asn His Lys Asp Asn Thr Lys Lys Ser Asp Lys Thr 
    50                  55                  60                  


Leu Gln Ala Ile Gln Arg Val Gly Gln Ala Val Asn Leu Ala Val Gly 
65                  70                  75                  80  


Arg Phe Val Lys Val Gly Glu Ala Ile Ala Asn Glu Asn Trp Asp Leu 
                85                  90                  95      


Lys Glu Glu Ile Asn Ile Ala Cys Ile Glu Ala Lys Gln Ala Gly Glu 
            100                 105                 110         


Thr Ile Ala Ala Leu Thr Asp Ile Thr Asn Leu Asn His Leu Glu Ser 
        115                 120                 125             


Asp Gly Gln Ile Thr Ile Phe Thr Asp Lys Thr Gly Val Ile Lys Ala 
    130                 135                 140                 


Ala Arg Leu Leu Leu Ser Ser Val Thr Lys Val Leu Leu Leu Ala Asp 
145                 150                 155                 160 


Arg Val Val Ile Lys Gln Ile Ile Thr Ser Arg Asn Lys Val Leu Ala 
                165                 170                 175     


Thr Met Glu Arg Leu Glu Lys Val Asn Ser Phe Gln Glu Phe Val Gln 
            180                 185                 190         


Ile Phe Ser Gln Phe Gly Asn Glu Met Val Glu Phe Ala His Leu Ser 
        195                 200                 205             


Gly Asp Arg Gln Asn Asp Leu Lys Asp Glu Lys Lys Lys Ala Lys Met 
    210                 215                 220                 


Ala Ala Ala Arg Ala Val Leu Glu Lys Cys Thr Met Met Leu Leu Thr 
225                 230                 235                 240 


Ala Ser Lys Thr Cys Leu Arg His Pro Asn Cys Glu Ser Ala His Lys 
                245                 250                 255     


Asn Lys Glu Gly Val Phe Asp Arg Met Lys Val Ala Leu Asp Lys Val 
            260                 265                 270         


Ile Glu Ile Val Thr Asp Cys Lys Pro Asn Gly Glu Thr Asp Ile Ser 
        275                 280                 285             


Ser Ile Ser Ile Phe Thr Gly Ile Lys Glu Phe Lys Met Asn Ile Glu 
    290                 295                 300                 


Ala Leu Arg Glu Asn Leu Tyr Phe Gln Ser Lys Glu Asn Leu Ser Val 
305                 310                 315                 320 


Thr Leu Glu Val Ile Leu Glu Arg Met Glu Asp Phe Thr Asp Ser Ala 
                325                 330                 335     


Tyr Thr Ser His Glu His Arg Glu Arg Ile Leu Glu Leu Ser Thr Gln 
            340                 345                 350         


Ala Arg Met Glu Leu Gln Gln Leu Ile Ser Val Trp Ile Gln Ala Gln 
        355                 360                 365             


Ser Lys Lys Thr Lys Ser Ile Ala Glu Glu Leu Glu Leu Ser Ile Leu 
    370                 375                 380                 


Lys Ile Ser His Ser Leu Asn Glu Leu Lys Lys Glu Leu His Ser Thr 
385                 390                 395                 400 


Ala Thr Gln Leu Ala Ala Asp Leu Leu Lys Tyr His Ala Asp His Val 
                405                 410                 415     


Val Leu Lys Ala Leu Lys Leu Thr Gly Val Glu Gly Asn Leu Glu Ala 
            420                 425                 430         


Leu Ala Glu Tyr Ala Cys Lys Leu Ser Glu Gln Lys Glu Gln Leu Val 
        435                 440                 445             


Glu Thr Cys Arg Leu Leu Arg His Ile Ser Gly Thr Glu Pro Leu Glu 
    450                 455                 460                 


Ile Thr Cys Ile His Ala Glu Glu Thr Phe Gln Val Thr Gly Gln Gln 
465                 470                 475                 480 


Ile Ile Ser Ala Ala Glu Thr Leu Thr Leu His Pro Ser Ser Lys Ile 
                485                 490                 495     


Ala Lys Glu Asn Leu Asp Val Phe Cys Glu Ala Trp Glu Ser Gln Ile 
            500                 505                 510         


Ser Asp Met Ser Thr Leu Leu Arg Glu Ile Asn Asp Val Phe Glu Gly 
        515                 520                 525             


Arg Arg Gly Glu Lys Tyr Gly Tyr Leu Ser Leu Pro Lys Pro Met Lys 
    530                 535                 540                 


Asn Asn Ala Asn Leu Lys Ser Leu Lys Pro Asp Lys Pro Asp Ser Glu 
545                 550                 555                 560 


Glu Gln Ala Lys Ile Ala Lys Leu Gly Leu Lys Leu Gly Leu Leu Thr 
                565                 570                 575     


Ser Asp Ala Asp Cys Glu Ile Glu Lys Trp Glu Asp Gln Glu Asn Glu 
            580                 585                 590         


Ile Val Gln Tyr Gly Arg Asn Met Ser Ser Met Ala Tyr Ser Leu Tyr 
        595                 600                 605             


Leu Phe Thr Arg Gly Glu Gly Pro Leu Lys Thr Ser Gln Asp Leu Ile 
    610                 615                 620                 


His Gln Leu Glu Val Phe Ala Ala Glu Gly Leu Lys Leu Thr Ser Ser 
625                 630                 635                 640 


Val Gln Ala Phe Ser Lys Gln Leu Lys Asp Asp Asp Lys Leu Met Leu 
                645                 650                 655     


Leu Leu Glu Ile Asn Lys Leu Ile Pro Leu Cys His Gln Leu Gln Thr 
            660                 665                 670         


Val Thr Lys Thr Ser Leu Gln Asn Lys Val Phe Leu Lys Val Asp Lys 
        675                 680                 685             


Cys Ile Thr Lys Thr Arg Ser Met Met Ala Leu Leu Val Gln Leu Leu 
    690                 695                 700                 


Ser Leu Cys Tyr Lys Leu Leu Lys Lys Ser Glu Thr Arg Tyr 
705                 710                 715             


<210>  137
<211>  650
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Ala Ala Ser Pro Gly Pro Ala Gly Val Gly Gly Ala Gly Ala Val 
1               5                   10                  15      


Tyr Gly Ser Gly Ser Ser Gly Phe Ala Leu Asp Ser Gly Leu Glu Ile 
            20                  25                  30          


Lys Thr Arg Ser Val Glu Gln Thr Leu Leu Pro Leu Val Ser Gln Ile 
        35                  40                  45              


Thr Thr Leu Ile Asn His Lys Asp Asn Thr Lys Lys Ser Asp Lys Thr 
    50                  55                  60                  


Leu Gln Ala Ile Gln Arg Val Gly Gln Ala Val Asn Leu Ala Val Gly 
65                  70                  75                  80  


Arg Phe Val Lys Val Gly Glu Ala Ile Ala Asn Glu Asn Trp Asp Leu 
                85                  90                  95      


Lys Glu Glu Ile Asn Ile Ala Cys Ile Glu Ala Lys Gln Ala Gly Glu 
            100                 105                 110         


Thr Ile Ala Ala Leu Thr Asp Ile Thr Asn Leu Asn His Leu Glu Ser 
        115                 120                 125             


Asp Gly Gln Ile Thr Ile Phe Thr Asp Lys Thr Gly Val Ile Lys Ala 
    130                 135                 140                 


Ala Arg Leu Leu Leu Ser Ser Val Thr Lys Val Leu Leu Leu Ala Asp 
145                 150                 155                 160 


Arg Val Val Ile Lys Gln Ile Ile Thr Ser Arg Asn Lys Val Leu Ala 
                165                 170                 175     


Thr Met Glu Arg Leu Glu Lys Val Asn Ser Phe Gln Glu Phe Val Gln 
            180                 185                 190         


Ile Phe Ser Gln Phe Gly Asn Glu Met Val Glu Phe Ala His Leu Ser 
        195                 200                 205             


Gly Asp Arg Gln Asn Asp Leu Lys Asp Glu Lys Lys Lys Ala Lys Met 
    210                 215                 220                 


Ala Ala Ala Arg Ala Val Leu Glu Lys Cys Thr Met Met Leu Leu Thr 
225                 230                 235                 240 


Ala Ser Lys Thr Cys Leu Arg His Pro Asn Cys Glu Ser Ala His Lys 
                245                 250                 255     


Asn Lys Glu Gly Val Phe Asp Arg Met Lys Val Ala Leu Asp Lys Val 
            260                 265                 270         


Ile Glu Ile Val Thr Asp Cys Lys Pro Asn Gly Glu Thr Asp Ile Ser 
        275                 280                 285             


Ser Ile Ser Ile Phe Thr Gly Ile Lys Glu Phe Lys Met Asn Ile Glu 
    290                 295                 300                 


Ala Leu Arg Glu Asn Leu Tyr Phe Gln Ser Lys Glu Asn Leu Ser Val 
305                 310                 315                 320 


Thr Leu Glu Val Ile Leu Glu Arg Met Glu Asp Phe Thr Asp Ser Ala 
                325                 330                 335     


Tyr Thr Ser His Glu His Arg Glu Arg Ile Leu Glu Leu Ser Thr Gln 
            340                 345                 350         


Ala Arg Met Glu Leu Gln Gln Leu Ile Ser Val Trp Ile Gln Ala Gln 
        355                 360                 365             


Ser Lys Lys Thr Lys Ser Ile Ala Glu Glu Leu Glu Leu Ser Ile Leu 
    370                 375                 380                 


Lys Ile Ser His Ser Leu Asn Glu Leu Lys Lys Glu Ile Ile Ser Ala 
385                 390                 395                 400 


Ala Glu Thr Leu Thr Leu His Pro Ser Ser Lys Ile Ala Lys Glu Asn 
                405                 410                 415     


Leu Asp Val Phe Cys Glu Ala Trp Glu Ser Gln Ile Ser Asp Met Ser 
            420                 425                 430         


Thr Leu Leu Arg Glu Ile Asn Asp Val Phe Glu Gly Arg Arg Gly Glu 
        435                 440                 445             


Lys Tyr Gly Tyr Leu Ser Leu Pro Lys Pro Met Lys Asn Asn Ala Asn 
    450                 455                 460                 


Leu Lys Ser Leu Lys Pro Asp Lys Pro Asp Ser Glu Glu Gln Ala Lys 
465                 470                 475                 480 


Ile Ala Lys Leu Gly Leu Lys Leu Gly Leu Leu Thr Ser Asp Ala Asp 
                485                 490                 495     


Cys Glu Ile Glu Lys Trp Glu Asp Gln Glu Asn Glu Ile Val Gln Tyr 
            500                 505                 510         


Gly Arg Asn Met Ser Ser Met Ala Tyr Ser Leu Tyr Leu Phe Thr Arg 
        515                 520                 525             


Gly Glu Gly Pro Leu Lys Thr Ser Gln Asp Leu Ile His Gln Leu Glu 
    530                 535                 540                 


Val Phe Ala Ala Glu Gly Leu Lys Leu Thr Ser Ser Val Gln Ala Phe 
545                 550                 555                 560 


Ser Lys Gln Leu Lys Asp Asp Asp Lys Leu Met Leu Leu Leu Glu Ile 
                565                 570                 575     


Asn Lys Leu Ile Pro Leu Cys His Gln Leu Gln Thr Val Thr Lys Thr 
            580                 585                 590         


Ser Leu Gln Asn Lys Val Phe Leu Lys Val Asp Lys Cys Ile Thr Lys 
        595                 600                 605             


Thr Arg Ser Met Met Ala Leu Leu Val Gln Leu Leu Ser Leu Cys Tyr 
    610                 615                 620                 


Lys Leu Leu Lys Lys Leu Gln Met Glu Asn Asn Gly Trp Val Ser Val 
625                 630                 635                 640 


Thr Asn Lys Asp Thr Met Asp Ser Lys Thr 
                645                 650 


<210>  138
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210>  139
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu 
1               5                   10                  15      


Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro 
            20                  25                  30          


Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu 
        35                  40                  45              


Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val 
    50                  55                  60                  


Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro Gly His Leu 
65                  70                  75                  80  


Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe 
                85                  90                  95      


Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro 
            100                 105                 110         


Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe 
        115                 120                 125             


Glu Val Tyr Glu Lys Asn Asp 
    130                 135 


<210>  140
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Gly Lys Asp Tyr Tyr Cys Ile Leu Gly Ile Glu Lys Gly Ala Ser 
1               5                   10                  15      


Asp Glu Asp Ile Lys Lys Ala Tyr Arg Lys Gln Ala Leu Lys Phe His 
            20                  25                  30          


Pro Asp Lys Asn Lys Ser Pro Gln Ala Glu Glu Lys Phe Lys Glu Val 
        35                  40                  45              


Ala Glu Ala Tyr Glu Val Leu Ser Asp Pro Lys Lys Arg Glu Ile Tyr 
    50                  55                  60                  


Asp Gln Phe Gly Glu Glu Gly Leu Lys Gly Gly Ala Gly Gly Thr Asp 
65                  70                  75                  80  


Gly Gln Gly Gly Thr Phe Arg Tyr Thr Phe His Gly Asp Pro His Ala 
                85                  90                  95      


Thr Phe Ala Ala Phe Phe Gly Gly Ser Asn Pro Phe Glu Ile Phe Phe 
            100                 105                 110         


Gly Arg Arg Met Gly Gly Gly Arg Asp Ser Glu Glu Met Glu Ile Asp 
        115                 120                 125             


Gly Asp Pro Phe Ser Ala Phe Gly Phe Ser Met Asn Gly Tyr Pro Arg 
    130                 135                 140                 


Asp Arg Asn Ser Val Gly Pro Ser Arg Leu Lys Gln Asp Pro Pro Val 
145                 150                 155                 160 


Ile His Glu Leu Arg Val Ser Leu Glu Glu Ile Tyr Ser Gly Cys Thr 
                165                 170                 175     


Lys Arg Met Lys Ile Ser Arg Lys Arg Leu Asn Ala Asp Gly Arg Ser 
            180                 185                 190         


Tyr Arg Ser Glu Asp Lys Ile Leu Thr Ile Glu Ile Lys Lys Gly Trp 
        195                 200                 205             


Lys Glu Gly Thr Lys Ile Thr Phe Pro Arg Glu Gly Asp Glu Thr Pro 
    210                 215                 220                 


Asn Ser Ile Pro Ala Asp Ile Val Phe Ile Ile Lys Asp Lys Asp His 
225                 230                 235                 240 


Pro Lys Phe Lys Arg Asp Gly Ser Asn Ile Ile Tyr Thr Ala Lys Ile 
                245                 250                 255     


Ser Leu Arg Glu Ala Leu Cys Gly Cys Ser Ile Asn Val Pro Thr Leu 
            260                 265                 270         


Asp Gly Arg Asn Ile Pro Met Ser Val Asn Asp Ile Val Lys Pro Gly 
        275                 280                 285             


Met Arg Arg Arg Ile Ile Gly Tyr Gly Leu Pro Phe Pro Lys Asn Pro 
    290                 295                 300                 


Asp Gln Arg Gly Asp Leu Leu Ile Glu Phe Glu Val Ser Phe Pro Asp 
305                 310                 315                 320 


Thr Ile Ser Ser Ser Ser Lys Glu Val Leu Arg Lys His Leu Pro Ala 
                325                 330                 335     


Ser 
    


<210>  141
<211>  1025
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Ala Pro Val Leu Ser Lys Asp Ser Ala Asp Ile Glu Ser Ile Leu 
1               5                   10                  15      


Ala Leu Asn Pro Arg Thr Gln Thr His Ala Thr Leu Cys Ser Thr Ser 
            20                  25                  30          


Ala Lys Lys Leu Asp Lys Lys His Trp Lys Arg Asn Pro Asp Lys Asn 
        35                  40                  45              


Cys Phe Asn Cys Glu Lys Leu Glu Asn Asn Phe Asp Asp Ile Lys His 
    50                  55                  60                  


Thr Thr Leu Gly Glu Arg Gly Ala Leu Arg Glu Ala Met Arg Cys Leu 
65                  70                  75                  80  


Lys Cys Ala Asp Ala Pro Cys Gln Lys Ser Cys Pro Thr Asn Leu Asp 
                85                  90                  95      


Ile Lys Ser Phe Ile Thr Ser Ile Ala Asn Lys Asn Tyr Tyr Gly Ala 
            100                 105                 110         


Ala Lys Met Ile Phe Ser Asp Asn Pro Leu Gly Leu Thr Cys Gly Met 
        115                 120                 125             


Val Cys Pro Thr Ser Asp Leu Cys Val Gly Gly Cys Asn Leu Tyr Ala 
    130                 135                 140                 


Thr Glu Glu Gly Pro Ile Asn Ile Gly Gly Leu Gln Gln Phe Ala Thr 
145                 150                 155                 160 


Glu Val Phe Lys Ala Met Ser Ile Pro Gln Ile Arg Asn Pro Ser Leu 
                165                 170                 175     


Pro Pro Pro Glu Lys Met Ser Glu Ala Tyr Ser Ala Lys Ile Ala Leu 
            180                 185                 190         


Phe Gly Ala Gly Pro Ala Ser Ile Ser Cys Ala Ser Phe Leu Ala Arg 
        195                 200                 205             


Leu Gly Tyr Ser Asp Ile Thr Ile Phe Glu Lys Gln Glu Tyr Val Gly 
    210                 215                 220                 


Gly Leu Ser Thr Ser Glu Ile Pro Gln Phe Arg Leu Pro Tyr Asp Val 
225                 230                 235                 240 


Val Asn Phe Glu Ile Glu Leu Met Lys Asp Leu Gly Val Lys Ile Ile 
                245                 250                 255     


Cys Gly Lys Ser Leu Ser Val Asn Glu Met Thr Leu Ser Thr Leu Lys 
            260                 265                 270         


Glu Lys Gly Tyr Lys Ala Ala Phe Ile Gly Ile Gly Leu Pro Glu Pro 
        275                 280                 285             


Asn Lys Asp Ala Ile Phe Gln Gly Leu Thr Gln Asp Gln Gly Phe Tyr 
    290                 295                 300                 


Thr Ser Lys Asp Phe Leu Pro Leu Val Ala Lys Gly Ser Lys Ala Gly 
305                 310                 315                 320 


Met Cys Ala Cys His Ser Pro Leu Pro Ser Ile Arg Gly Val Val Ile 
                325                 330                 335     


Val Leu Gly Ala Gly Asp Thr Ala Phe Asp Cys Ala Thr Ser Ala Leu 
            340                 345                 350         


Arg Cys Gly Ala Arg Arg Val Phe Ile Val Phe Arg Lys Gly Phe Val 
        355                 360                 365             


Asn Ile Arg Ala Val Pro Glu Glu Met Glu Leu Ala Lys Glu Glu Lys 
    370                 375                 380                 


Cys Glu Phe Leu Pro Phe Leu Ser Pro Arg Lys Val Ile Val Lys Gly 
385                 390                 395                 400 


Gly Arg Ile Val Ala Met Gln Phe Val Arg Thr Glu Gln Asp Glu Thr 
                405                 410                 415     


Gly Lys Trp Asn Glu Asp Glu Asp Gln Met Val His Leu Lys Ala Asp 
            420                 425                 430         


Val Val Ile Ser Ala Phe Gly Ser Val Leu Ser Asp Pro Lys Val Lys 
        435                 440                 445             


Glu Ala Leu Ser Pro Ile Lys Phe Asn Arg Trp Gly Leu Pro Glu Val 
    450                 455                 460                 


Asp Pro Glu Thr Met Gln Thr Ser Glu Ala Trp Val Phe Ala Gly Gly 
465                 470                 475                 480 


Asp Val Val Gly Leu Ala Asn Thr Thr Val Glu Ser Val Asn Asp Gly 
                485                 490                 495     


Lys Gln Ala Ser Trp Tyr Ile His Lys Tyr Val Gln Ser Gln Tyr Gly 
            500                 505                 510         


Ala Ser Val Ser Ala Lys Pro Glu Leu Pro Leu Phe Tyr Thr Pro Ile 
        515                 520                 525             


Asp Leu Val Asp Ile Ser Val Glu Met Ala Gly Leu Lys Phe Ile Asn 
    530                 535                 540                 


Pro Phe Gly Leu Ala Ser Ala Thr Pro Ala Thr Ser Thr Ser Met Ile 
545                 550                 555                 560 


Arg Arg Ala Phe Glu Ala Gly Trp Gly Phe Ala Leu Thr Lys Thr Phe 
                565                 570                 575     


Ser Leu Asp Lys Asp Ile Val Thr Asn Val Ser Pro Arg Ile Ile Arg 
            580                 585                 590         


Gly Thr Thr Ser Gly Pro Met Tyr Gly Pro Gly Gln Ser Ser Phe Leu 
        595                 600                 605             


Asn Ile Glu Leu Ile Ser Glu Lys Thr Ala Ala Tyr Trp Cys Gln Ser 
    610                 615                 620                 


Val Thr Glu Leu Lys Ala Asp Phe Pro Asp Asn Ile Val Ile Ala Ser 
625                 630                 635                 640 


Ile Met Cys Ser Tyr Asn Lys Asn Asp Trp Thr Glu Leu Ala Lys Lys 
                645                 650                 655     


Ser Glu Asp Ser Gly Ala Asp Ala Leu Glu Leu Asn Leu Ser Cys Pro 
            660                 665                 670         


His Gly Met Gly Glu Arg Gly Met Gly Leu Ala Cys Gly Gln Asp Pro 
        675                 680                 685             


Glu Leu Val Arg Asn Ile Cys Arg Trp Val Arg Gln Ala Val Gln Ile 
    690                 695                 700                 


Pro Phe Phe Ala Lys Leu Thr Pro Asn Val Thr Asp Ile Val Ser Ile 
705                 710                 715                 720 


Ala Arg Ala Ala Lys Glu Gly Gly Ala Asn Gly Val Thr Ala Thr Asn 
                725                 730                 735     


Thr Val Ser Gly Leu Met Gly Leu Lys Ser Asp Gly Thr Pro Trp Pro 
            740                 745                 750         


Ala Val Gly Ile Ala Lys Arg Thr Thr Tyr Gly Gly Val Ser Gly Thr 
        755                 760                 765             


Ala Ile Arg Pro Ile Ala Leu Arg Ala Val Thr Ser Ile Ala Arg Ala 
    770                 775                 780                 


Leu Pro Gly Phe Pro Ile Leu Ala Thr Gly Gly Ile Asp Ser Ala Glu 
785                 790                 795                 800 


Ser Gly Leu Gln Phe Leu His Ser Gly Ala Ser Val Leu Gln Val Cys 
                805                 810                 815     


Ser Ala Ile Gln Asn Gln Asp Phe Thr Val Ile Glu Asp Tyr Cys Thr 
            820                 825                 830         


Gly Leu Lys Ala Leu Leu Tyr Leu Lys Ser Ile Glu Glu Leu Gln Asp 
        835                 840                 845             


Trp Asp Gly Gln Ser Pro Ala Thr Val Ser His Gln Lys Gly Lys Pro 
    850                 855                 860                 


Val Pro Arg Ile Ala Glu Leu Met Asp Lys Lys Leu Pro Ser Phe Gly 
865                 870                 875                 880 


Pro Tyr Leu Glu Gln Arg Lys Lys Ile Ile Ala Glu Asn Lys Ile Arg 
                885                 890                 895     


Leu Lys Glu Gln Asn Val Ala Phe Ser Pro Leu Lys Arg Asn Cys Phe 
            900                 905                 910         


Ile Pro Lys Arg Pro Ile Pro Thr Ile Lys Asp Val Ile Gly Lys Ala 
        915                 920                 925             


Leu Gln Tyr Leu Gly Thr Phe Gly Glu Leu Ser Asn Val Glu Gln Val 
    930                 935                 940                 


Val Ala Met Ile Asp Glu Glu Met Cys Ile Asn Cys Gly Lys Cys Tyr 
945                 950                 955                 960 


Met Thr Cys Asn Asp Ser Gly Tyr Gln Ala Ile Gln Phe Asp Pro Glu 
                965                 970                 975     


Thr His Leu Pro Thr Ile Thr Asp Thr Cys Thr Gly Cys Thr Leu Cys 
            980                 985                 990         


Leu Ser Val Cys Pro Ile Val Asp  Cys Ile Lys Met Val  Ser Arg Thr 
        995                 1000                 1005             


Thr Pro  Tyr Glu Pro Lys Arg  Gly Val Pro Leu Ser  Val Asn Pro 
    1010                 1015                 1020             


Val Cys  
    1025 


<210>  142
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Ala Pro Val Leu Ser Lys Asp Ser Ala Asp Ile Glu Ser Ile Leu 
1               5                   10                  15      


Ala Leu Asn Pro Arg Thr Gln Thr His Ala Thr Leu Cys Ser Thr Ser 
            20                  25                  30          


Ala Lys Lys Leu Asp Lys Lys His Trp Lys Arg Asn Pro Asp Lys Asn 
        35                  40                  45              


Cys Phe Asn Cys Glu Lys Leu Glu Asn Asn Phe Asp Asp Ile Lys His 
    50                  55                  60                  


Thr Thr Leu Gly Glu Arg Gly Ala Leu Arg Glu Ala Met Arg Cys Leu 
65                  70                  75                  80  


Lys Cys Ala Asp Ala Pro Cys Gln Lys Ser Cys Pro Thr Asn Leu Asp 
                85                  90                  95      


Ile Lys Ser Phe Ile Thr Ser Ile Ala Asn Lys Asn Tyr Tyr Gly Ala 
            100                 105                 110         


Ala Lys Met Ile Phe Ser Asp Asn Pro Leu Gly Leu Thr Cys Gly Met 
        115                 120                 125             


Val Cys Pro Thr Ser Asp Leu Cys Val Gly Gly Cys Asn Leu Tyr Ala 
    130                 135                 140                 


Thr Glu Glu Gly Pro Ile Asn Ile Gly Gly Leu Gln Gln Phe Ala Thr 
145                 150                 155                 160 


Glu Thr Leu Ile Leu Ala Phe Ser Leu Met Asn His Leu 
                165                 170             


<210>  143
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Gln Arg Pro Gly Pro Arg Leu Trp Leu Val Leu Gln Val Met Gly 
1               5                   10                  15      


Ser Cys Ala Ala Ile Ser Ser Met Asp Met Glu Arg Pro Gly Asp Gly 
            20                  25                  30          


Lys Cys Gln Pro Ile Glu Ile Pro Met Cys Lys Asp Ile Gly Tyr Asn 
        35                  40                  45              


Met Thr Arg Met Pro Asn Leu Met Gly His Glu Asn Gln Arg Glu Ala 
    50                  55                  60                  


Ala Ile Gln Leu His Glu Phe Ala Pro Leu Val Glu Tyr Gly Cys His 
65                  70                  75                  80  


Gly His Leu Arg Phe Phe Leu Cys Ser Leu Tyr Ala Pro Met Cys Thr 
                85                  90                  95      


Glu Gln Val Ser Thr Pro Ile Pro Ala Cys Arg Val Met Cys Glu Gln 
            100                 105                 110         


Ala Arg Leu Lys Cys Ser Pro Ile Met Glu Gln Phe Asn Phe Lys Trp 
        115                 120                 125             


Pro Asp Ser Leu Asp Cys Arg Lys Leu Pro Asn Lys Asn Asp Pro Asn 
    130                 135                 140                 


Tyr Leu Cys Met Glu Ala Pro Asn Asn Gly Ser Asp Glu Pro Thr Arg 
145                 150                 155                 160 


Gly Ser Gly Leu Phe Pro Pro Leu Phe Arg Pro Gln Arg Pro His Ser 
                165                 170                 175     


Ala Gln Glu His Pro Leu Lys Asp Gly Gly Pro Gly Arg Gly Gly Cys 
            180                 185                 190         


Asp Asn Pro Gly Lys Phe His His Val Glu Lys Ser Ala Ser Cys Ala 
        195                 200                 205             


Pro Leu Cys Thr Pro Gly Val Asp Val Tyr Trp Ser Arg Glu Asp Lys 
    210                 215                 220                 


Arg Phe Ala Val Val Trp Leu Ala Ile Trp Ala Val Leu Cys Phe Phe 
225                 230                 235                 240 


Ser Ser Ala Phe Thr Val Leu Thr Phe Leu Ile Asp Pro Ala Arg Phe 
                245                 250                 255     


Arg Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Met Cys Tyr Cys Val 
            260                 265                 270         


Tyr Ser Val Gly Tyr Leu Ile Arg Leu Phe Ala Gly Ala Glu Ser Ile 
        275                 280                 285             


Ala Cys Asp Arg Asp Ser Gly Gln Leu Tyr Val Ile Gln Glu Gly Leu 
    290                 295                 300                 


Glu Ser Thr Gly Cys Thr Leu Val Phe Leu Val Leu Tyr Tyr Phe Gly 
305                 310                 315                 320 


Met Ala Ser Ser Leu Trp Trp Val Val Leu Thr Leu Thr Trp Phe Leu 
                325                 330                 335     


Ala Ala Gly Lys Lys Trp Gly His Glu Ala Ile Glu Ala Asn Ser Ser 
            340                 345                 350         


Tyr Phe His Leu Ala Ala Trp Ala Ile Pro Ala Val Lys Thr Ile Leu 
        355                 360                 365             


Ile Leu Val Met Arg Arg Val Ala Gly Asp Glu Leu Thr Gly Val Cys 
    370                 375                 380                 


Tyr Val Gly Ser Met Asp Val Asn Ala Leu Thr Gly Phe Val Leu Ile 
385                 390                 395                 400 


Pro Leu Ala Cys Tyr Leu Val Ile Gly Thr Ser Phe Ile Leu Ser Gly 
                405                 410                 415     


Phe Val Ala Leu Phe His Ile Arg Arg Val Met Lys Thr Gly Gly Glu 
            420                 425                 430         


Asn Thr Asp Lys Leu Glu Lys Leu Met Val Arg Ile Gly Leu Phe Ser 
        435                 440                 445             


Val Leu Tyr Thr Val Pro Ala Thr Cys Val Ile Ala Cys Tyr Phe Tyr 
    450                 455                 460                 


Glu Arg Leu Asn Met Asp Tyr Trp Lys Ile Leu Ala Ala Gln His Lys 
465                 470                 475                 480 


Cys Lys Met Asn Asn Gln Thr Lys Thr Leu Asp Cys Leu Met Ala Ala 
                485                 490                 495     


Ser Ile Pro Ala Val Glu Ile Phe Met Val Lys Ile Phe Met Leu Leu 
            500                 505                 510         


Val Val Gly Ile Thr Ser Gly Met Trp Ile Trp Thr Ser Lys Thr Leu 
        515                 520                 525             


Gln Ser Trp Gln Gln Val Cys Ser Arg Arg Leu Lys Lys Lys Ser Arg 
    530                 535                 540                 


Arg Lys Pro Ala Ser Val Ile Thr Ser Gly Gly Ile Tyr Lys Lys Ala 
545                 550                 555                 560 


Gln His Pro Gln Lys Thr His His Gly Lys Tyr Glu Ile Pro Ala Gln 
                565                 570                 575     


Ser Pro Thr Cys Val 
            580     


<210>  144
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Ser Gly Gly Glu Val Val Cys Ser Gly Trp Leu Arg Lys Ser Pro 
1               5                   10                  15      


Pro Glu Lys Lys Leu Lys Arg Tyr Ala Trp Lys Arg Arg Trp Phe Val 
            20                  25                  30          


Leu Arg Ser Gly Arg Leu Thr Gly Asp Pro Asp Val Leu Glu Tyr Tyr 
        35                  40                  45              


Lys Asn Asp His Ala Lys Lys Pro Ile Arg Ile Ile Asp Leu Asn Leu 
    50                  55                  60                  


Cys Gln Gln Val Asp Ala Gly Leu Thr Phe Asn Lys Lys Glu Phe Glu 
65                  70                  75                  80  


Asn Ser Tyr Ile Phe Asp Ile Asn Thr Ile Asp Arg Ile Phe Tyr Leu 
                85                  90                  95      


Val Ala Asp Ser Glu Glu Glu Met Asn Lys Trp Val Arg Cys Ile Cys 
            100                 105                 110         


Asp Ile Cys Gly Phe Asn Pro Thr Glu Glu Asp Pro Val Lys Pro Pro 
        115                 120                 125             


Gly Ser Ser Leu Gln Ala Pro Ala Asp Leu Pro Leu Ala Ile Asn Thr 
    130                 135                 140                 


Ala Pro Pro Ser Thr Gln Ala Asp Ser Ser Ser Ala Thr Leu Pro Pro 
145                 150                 155                 160 


Pro Tyr Gln Leu Ile Asn Val Pro Pro His Leu Glu Thr Leu Gly Ile 
                165                 170                 175     


Gln Glu Asp Pro Gln Asp Tyr Leu Leu Leu Ile Asn Cys Gln Ser Lys 
            180                 185                 190         


Lys Pro Glu Pro Thr Arg Thr His Ala Asp Ser Ala Lys Ser Thr Ser 
        195                 200                 205             


Ser Glu Thr Asp Cys Asn Asp Asn Val Pro Ser His Lys Asn Pro Ala 
    210                 215                 220                 


Ser Ser Gln Ser Lys His Gly Met Asn Gly Phe Phe Gln Gln Gln Met 
225                 230                 235                 240 


Ile Tyr Asp Ser Pro Pro Ser Arg Ala Pro Ser Ala Ser Val Asp Ser 
                245                 250                 255     


Ser Leu Tyr Asn Leu Pro Arg Ser Tyr Ser His Asp Val Leu Pro Lys 
            260                 265                 270         


Val Ser Pro Ser Ser Thr Glu Ala Asp Gly Glu Leu Tyr Val Phe Asn 
        275                 280                 285             


Thr Pro Ser Gly Thr Ser Ser Val Glu Thr Gln Met Arg His Val Ser 
    290                 295                 300                 


Ile Ser Tyr Asp Ile Pro Pro Thr Pro Gly Asn Thr Tyr Gln Ile Pro 
305                 310                 315                 320 


Arg Thr Phe Pro Glu Gly Thr Leu Gly Gln Thr Ser Lys Leu Asp Thr 
                325                 330                 335     


Ile Pro Asp Ile Pro Pro Pro Arg Pro Pro Lys Pro His Pro Ala His 
            340                 345                 350         


Asp Arg Ser Pro Val Glu Thr Cys Ser Ile Pro Arg Thr Ala Ser Asp 
        355                 360                 365             


Thr Asp Ser Ser Tyr Cys Ile Pro Thr Ala Gly Met Ser Pro Ser Arg 
    370                 375                 380                 


Ser Asn Thr Ile Ser Thr Val Asp Leu Asn Lys Leu Arg Lys Asp Ala 
385                 390                 395                 400 


Ser Ser Gln Asp Cys Tyr Asp Ile Pro Arg Ala Phe Pro Ser Asp Arg 
                405                 410                 415     


Ser Ser Ser Leu Glu Gly Phe His Asn His Phe Lys Val Lys Asn Val 
            420                 425                 430         


Leu Thr Val Gly Ser Val Ser Ser Glu Glu Leu Asp Glu Asn Tyr Val 
        435                 440                 445             


Pro Met Asn Pro Asn Ser Pro Pro Arg Gln His Ser Ser Ser Phe Thr 
    450                 455                 460                 


Glu Pro Ile Gln Glu Ala Asn Tyr Val Pro Met Thr Pro Gly Thr Phe 
465                 470                 475                 480 


Asp Phe Ser Ser Phe Gly Met Gln Val Pro Pro Pro Ala His Met Gly 
                485                 490                 495     


Phe Arg Ser Ser Pro Lys Thr Pro Pro Arg Arg Pro Val Pro Val Ala 
            500                 505                 510         


Asp Cys Glu Pro Pro Pro Val Asp Arg Asn Leu Lys Pro Asp Arg Lys 
        515                 520                 525             


Val Lys Pro Ala Pro Leu Glu Ile Lys Pro Leu Pro Glu Trp Glu Glu 
    530                 535                 540                 


Leu Gln Ala Pro Val Arg Ser Pro Ile Thr Arg Ser Phe Ala Arg Asp 
545                 550                 555                 560 


Ser Ser Arg Phe Pro Met Ser Pro Arg Pro Asp Ser Val His Ser Thr 
                565                 570                 575     


Thr Ser Ser Ser Asp Ser His Asp Ser Glu Glu Asn Tyr Val Pro Met 
            580                 585                 590         


Asn Pro Asn Leu Ser Ser Glu Asp Pro Asn Leu Phe Gly Ser Asn Ser 
        595                 600                 605             


Leu Asp Gly Gly Ser Ser Pro Met Ile Lys Pro Lys Gly Asp Lys Gln 
    610                 615                 620                 


Val Glu Tyr Leu Asp Leu Asp Leu Asp Ser Gly Lys Ser Thr Pro Pro 
625                 630                 635                 640 


Arg Lys Gln Lys Ser Ser Gly Ser Gly Ser Ser Val Ala Asp Glu Arg 
                645                 650                 655     


Val Asp Tyr Val Val Val Asp Gln Gln Lys Thr Leu Ala Leu Lys Ser 
            660                 665                 670         


Thr Arg Glu Ala Trp Thr Asp Gly Arg Gln Ser Thr Glu Ser Glu Thr 
        675                 680                 685             


Pro Ala Lys Ser Val Lys 
    690                 


<210>  145
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Ser Gly Gly Glu Val Val Cys Ser Gly Trp Leu Arg Lys Ser Pro 
1               5                   10                  15      


Pro Glu Lys Lys Leu Lys Arg Tyr Ala Trp Lys Arg Arg Trp Phe Val 
            20                  25                  30          


Leu Arg Ser Gly Arg Leu Thr Gly Asp Pro Asp Val Leu Glu Tyr Tyr 
        35                  40                  45              


Lys Asn Asp His Ala Lys Lys Pro Ile Arg Ile Ile Asp Leu Asn Leu 
    50                  55                  60                  


Cys Gln Gln Val Asp Ala Gly Leu Thr Phe Asn Lys Lys Glu Phe Glu 
65                  70                  75                  80  


Asn Ser Tyr Ile Phe Asp Ile Asn Thr Ile Asp Arg Ile Phe Tyr Leu 
                85                  90                  95      


Val Ala Asp Ser Glu Glu Glu Met Asn Lys Trp Val Arg Cys Ile Cys 
            100                 105                 110         


Asp Ile Cys Gly Phe Asn Pro Thr Glu Glu Asp Pro Val Lys Pro Pro 
        115                 120                 125             


Gly Ser Ser Leu Gln Ala Pro Ala Asp Leu Pro Leu Ala Ile Asn Thr 
    130                 135                 140                 


Ala Pro Pro Ser Thr Gln Ala Asp Ser Ser Ser Ala Thr Leu Pro Pro 
145                 150                 155                 160 


Pro Tyr Gln Leu Ile Asn Val Pro Pro His Leu Glu Thr Leu Gly Ile 
                165                 170                 175     


Gln Glu Asp Pro Gln Asp Tyr Leu Leu Leu Ile Asn Cys Gln Ser Lys 
            180                 185                 190         


Lys Pro Glu Pro Thr Arg Thr His Ala Asp Ser Ala Lys Ser Thr Ser 
        195                 200                 205             


Ser Glu Thr Asp Cys Asn Asp Asn Val Pro Ser His Lys Asn Pro Ala 
    210                 215                 220                 


Ser Ser Gln Ser Lys His Gly Met Asn Gly Phe Phe Gln Gln Gln Met 
225                 230                 235                 240 


Ile Tyr Asp Ser Pro Pro Ser Arg Ala Pro Ser Ala Ser Val Asp Ser 
                245                 250                 255     


Ser Leu Tyr Asn Leu Pro Arg Ser Tyr Ser His Asp Val Leu Pro Lys 
            260                 265                 270         


Val Ser Pro Ser Ser Thr Glu Ala Asp Gly Glu Leu Tyr Val Phe Asn 
        275                 280                 285             


Thr Pro Ser Gly Thr Ser Ser Val Glu Thr Gln Met Arg His Val Ser 
    290                 295                 300                 


Ile Ser Tyr Asp Ile Pro Pro Thr Pro Gly Asn Thr Tyr Gln Ile Pro 
305                 310                 315                 320 


Arg Thr Phe Pro Glu Gly Thr Leu Gly Gln Thr Ser Lys Leu Asp Thr 
                325                 330                 335     


Ile Pro Asp Ile Pro Pro Pro Arg Pro Pro Lys Pro His Pro Ala His 
            340                 345                 350         


Asp Arg Ser Pro Val Glu Thr Cys Ser Ile Pro Arg Thr Ala Ser Asp 
        355                 360                 365             


Thr Asp Ser Ser Tyr Cys Ile Pro Thr Ala Gly Met Ser Pro Ser Arg 
    370                 375                 380                 


Ser Asn Thr Ile Ser Thr Val Asp Leu Asn Lys Leu Arg Lys Asp Ala 
385                 390                 395                 400 


Ser Ser Gln Asp Cys Tyr Asp Ile Pro Arg Ala Phe Pro Ser Asp Arg 
                405                 410                 415     


Ser Ser Ser Leu Glu Gly Phe His Asn His Phe Lys Val Lys Asn Val 
            420                 425                 430         


Leu Thr Val Gly Ser Val Ser Ser Glu Glu Leu Asp Glu Asn Tyr Val 
        435                 440                 445             


Pro Met Asn Pro Asn Ser Pro Pro Arg Gln His Ser Ser Ser Phe Thr 
    450                 455                 460                 


Glu Pro Ile Gln Glu Ala Asn Tyr Val Pro Met Thr Pro Gly Thr Phe 
465                 470                 475                 480 


Asp Phe Ser Ser Phe Gly Met Gln Val Pro Pro Pro Ala His Met Gly 
                485                 490                 495     


Phe Arg Ser Ser Pro Lys Thr Pro Pro Arg Arg Pro Val Pro Val Ala 
            500                 505                 510         


Asp Cys Glu Pro Pro Pro Val Asp Arg Asn Leu Lys Pro Asp Arg Lys 
        515                 520                 525             


Gly Gln Ser Pro Lys Ile Leu Arg Leu Lys Pro His Gly Leu Glu Arg 
    530                 535                 540                 


Thr Asp Ser Gln Thr Ile Gly Asp Phe Ala Thr Arg Arg Lys Val Lys 
545                 550                 555                 560 


Pro Ala Pro Leu Glu Ile Lys Pro Leu Pro Glu Trp Glu Glu Leu Gln 
                565                 570                 575     


Ala Pro Val Arg Ser Pro Ile Thr Arg Ser Phe Ala Arg Asp Ser Ser 
            580                 585                 590         


Arg Phe Pro Met Ser Pro Arg Pro Asp Ser Val His Ser Thr Thr Ser 
        595                 600                 605             


Ser Ser Asp Ser His Asp Ser Glu Glu Asn Tyr Val Pro Met Asn Pro 
    610                 615                 620                 


Asn Leu Ser Ser Glu Asp Pro Asn Leu Phe Gly Ser Asn Ser Leu Asp 
625                 630                 635                 640 


Gly Gly Ser Ser Pro Met Ile Lys Pro Lys Gly Asp Lys Gln Val Glu 
                645                 650                 655     


Tyr Leu Asp Leu Asp Leu Asp Ser Gly Lys Ser Thr Pro Pro Arg Lys 
            660                 665                 670         


Gln Lys Ser Ser Gly Ser Gly Ser Ser Val Ala Asp Glu Arg Val Asp 
        675                 680                 685             


Tyr Val Val Val Asp Gln Gln Lys Thr Leu Ala Leu Lys Ser Thr Arg 
    690                 695                 700                 


Glu Ala Trp Thr Asp Gly Arg Gln Ser Thr Glu Ser Glu Thr Pro Ala 
705                 710                 715                 720 


Lys Ser Val Lys 
                


<210>  146
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Glu Pro Ser Ala Thr Pro Gly Ala Gln Met Gly Val Pro Pro Gly 
1               5                   10                  15      


Ser Arg Glu Pro Ser Pro Val Pro Pro Asp Tyr Glu Asp Glu Phe Leu 
            20                  25                  30          


Arg Tyr Leu Trp Arg Asp Tyr Leu Tyr Pro Lys Gln Tyr Glu Trp Val 
        35                  40                  45              


Leu Ile Ala Ala Tyr Val Ala Val Phe Val Val Ala Leu Val Gly Asn 
    50                  55                  60                  


Thr Leu Val Cys Leu Ala Val Trp Arg Asn His His Met Arg Thr Val 
65                  70                  75                  80  


Thr Asn Tyr Phe Ile Val Asn Leu Ser Leu Ala Asp Val Leu Val Thr 
                85                  90                  95      


Ala Ile Cys Leu Pro Ala Ser Leu Leu Val Asp Ile Thr Glu Ser Trp 
            100                 105                 110         


Leu Phe Gly His Ala Leu Cys Lys Val Ile Pro Tyr Leu Gln Ala Val 
        115                 120                 125             


Ser Val Ser Val Ala Val Leu Thr Leu Ser Phe Ile Ala Leu Asp Arg 
    130                 135                 140                 


Trp Tyr Ala Ile Cys His Pro Leu Leu Phe Lys Ser Thr Ala Arg Arg 
145                 150                 155                 160 


Ala Arg Gly Ser Ile Leu Gly Ile Trp Ala Val Ser Leu Ala Ile Met 
                165                 170                 175     


Val Pro Gln Ala Ala Val Met Glu Cys Ser Ser Val Leu Pro Glu Leu 
            180                 185                 190         


Ala Asn Arg Thr Arg Leu Phe Ser Val Cys Asp Glu Arg Trp Ala Asp 
        195                 200                 205             


Asp Leu Tyr Pro Lys Ile Tyr His Ser Cys Phe Phe Ile Val Thr Tyr 
    210                 215                 220                 


Leu Ala Pro Leu Gly Leu Met Ala Met Ala Tyr Phe Gln Ile Phe Arg 
225                 230                 235                 240 


Lys Leu Trp Gly Arg Gln Ile Pro Gly Thr Thr Ser Ala Leu Val Arg 
                245                 250                 255     


Asn Trp Lys Arg Pro Ser Asp Gln Leu Gly Asp Leu Glu Gln Gly Leu 
            260                 265                 270         


Ser Gly Glu Pro Gln Pro Arg Ala Arg Ala Phe Leu Ala Glu Val Lys 
        275                 280                 285             


Gln Met Arg Ala Arg Arg Lys Thr Ala Lys Met Leu Met Val Val Leu 
    290                 295                 300                 


Leu Val Phe Ala Leu Cys Tyr Leu Pro Ile Ser Val Leu Asn Val Leu 
305                 310                 315                 320 


Lys Arg Val Phe Gly Met Phe Arg Gln Ala Ser Asp Arg Glu Ala Val 
                325                 330                 335     


Tyr Ala Cys Phe Thr Phe Ser His Trp Leu Val Tyr Ala Asn Ser Ala 
            340                 345                 350         


Ala Asn Pro Ile Ile Tyr Asn Phe Leu Ser Gly Lys Phe Arg Glu Gln 
        355                 360                 365             


Phe Lys Ala Ala Phe Ser Cys Cys Leu Pro Gly Leu Gly Pro Cys Gly 
    370                 375                 380                 


Ser Leu Lys Ala Pro Ser Pro Arg Ser Ser Ala Ser His Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Gln Ser Arg Cys Ser Ile Ser Lys Ile Ser Glu His Val Val 
                405                 410                 415     


Leu Thr Ser Val Thr Thr Val Leu Pro 
            420                 425 


<210>  147
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210>  148
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Val Lys Gly Arg 
65                  70                  75                  80  


Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu 
                85                  90                  95      


Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu 
            100                 105                 110         


Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met 
        115                 120                 125             


Gly Thr Lys Glu His 
    130             


<210>  149
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe 
1               5                   10                  15      


Lys Arg His Ile Cys Asp Ala Asn Lys Glu Glu Asn Lys Ser Leu Lys 
            20                  25                  30          


Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln 
        35                  40                  45              


Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His 
    50                  55                  60                  


<210>  150
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Phe His Cys Ile Pro Leu Trp Arg Cys Asn Arg His Val Glu Ser 
1               5                   10                  15      


Ile Asp Lys Arg His Cys Ser Leu Val Tyr Val Pro Glu Glu Ile Tyr 
            20                  25                  30          


Arg Tyr Ala Arg Ser Leu Glu Glu Leu Leu Leu Asp Ala Asn Gln Leu 
        35                  40                  45              


Arg Glu Leu Pro Glu Gln Phe Phe Gln Leu Val Lys Leu Arg Lys Leu 
    50                  55                  60                  


Gly Leu Ser Asp Asn Glu Ile Gln Arg Leu Pro Pro Glu Ile Ala Asn 
65                  70                  75                  80  


Phe Met Gln Leu Val Glu Leu Asp Val Ser Arg Asn Glu Ile Pro Glu 
                85                  90                  95      


Ile Pro Glu Ser Ile Ser Phe Cys Lys Ala Leu Gln Val Ala Asp Phe 
            100                 105                 110         


Ser Gly Asn Pro Leu Thr Arg Leu Pro Glu Ser Phe Pro Glu Leu Gln 
        115                 120                 125             


Asn Leu Thr Cys Leu Ser Val Asn Asp Ile Ser Leu Gln Ser Leu Pro 
    130                 135                 140                 


Glu Asn Ile Gly Asn Leu Tyr Asn Leu Ala Ser Leu Glu Leu Arg Glu 
145                 150                 155                 160 


Asn Leu Leu Thr Tyr Leu Pro Asp Ser Leu Thr Gln Leu Arg Arg Leu 
                165                 170                 175     


Glu Glu Leu Asp Leu Gly Asn Asn Glu Ile Tyr Asn Leu Pro Glu Ser 
            180                 185                 190         


Ile Gly Ala Leu Leu His Leu Lys Asp Leu Trp Leu Asp Gly Asn Gln 
        195                 200                 205             


Leu Ser Glu Leu Pro Gln Glu Ile Gly Asn Leu Lys Asn Leu Leu Cys 
    210                 215                 220                 


Leu Asp Val Ser Glu Asn Arg Leu Glu Arg Leu Pro Glu Glu Ile Ser 
225                 230                 235                 240 


Gly Leu Thr Ser Leu Thr Asp Leu Val Ile Ser Gln Asn Leu Leu Glu 
                245                 250                 255     


Thr Ile Pro Asp Gly Ile Gly Lys Leu Lys Lys Leu Ser Ile Leu Lys 
            260                 265                 270         


Val Asp Gln Asn Arg Leu Thr Gln Leu Pro Glu Ala Val Gly Glu Cys 
        275                 280                 285             


Glu Ser Leu Thr Glu Leu Val Leu Thr Glu Asn Gln Leu Leu Thr Leu 
    290                 295                 300                 


Pro Lys Ser Ile Gly Lys Leu Lys Lys Leu Ser Asn Leu Asn Ala Asp 
305                 310                 315                 320 


Arg Asn Lys Leu Val Ser Leu Pro Lys Glu Ile Gly Gly Cys Cys Ser 
                325                 330                 335     


Leu Thr Val Phe Cys Val Arg Asp Asn Arg Leu Thr Arg Ile Pro Ala 
            340                 345                 350         


Glu Val Ser Gln Ala Thr Glu Leu His Val Leu Asp Val Ala Gly Asn 
        355                 360                 365             


Arg Leu Leu His Leu Pro Leu Ser Leu Thr Ala Leu Lys Leu Lys Ala 
    370                 375                 380                 


Leu Trp Leu Ser Asp Asn Gln Ser Gln Pro Leu Leu Thr Phe Gln Thr 
385                 390                 395                 400 


Asp Thr Asp Tyr Thr Thr Gly Glu Lys Ile Leu Thr Cys Val Leu Leu 
                405                 410                 415     


Pro Gln Leu Pro Ser Glu Pro Thr Cys Gln Glu Asn Leu Pro Arg Cys 
            420                 425                 430         


Gly Ala Leu Glu Asn Leu Val Asn Asp Val Ser Asp Glu Ala Trp Asn 
        435                 440                 445             


Glu Arg Ala Val Asn Arg Val Ser Ala Ile Arg Phe Val Glu Asp Glu 
    450                 455                 460                 


Lys Asp Glu Glu Asp Asn Glu Thr Arg Thr Leu Leu Arg Arg Ala Thr 
465                 470                 475                 480 


Pro His Pro Gly Glu Leu Lys His Met Lys Lys Thr Val Glu Asn Leu 
                485                 490                 495     


Arg Asn Asp Met Asn Ala Ala Lys Gly Leu Asp Ser Asn Lys Asn Glu 
            500                 505                 510         


Val Asn His Ala Ile Asp Arg Val Thr Thr Ser Val 
        515                 520                 


<210>  151
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Phe His Cys Ile Pro Leu Trp Arg Cys Asn Arg His Val Glu Ser 
1               5                   10                  15      


Ile Asp Lys Arg His Cys Ser Leu Val Tyr Val Pro Glu Glu Ile Tyr 
            20                  25                  30          


Arg Tyr Ala Arg Ser Leu Glu Glu Leu Leu Leu Asp Ala Asn Gln Leu 
        35                  40                  45              


Arg Glu Leu Pro Glu Gln Phe Phe Gln Leu Val Lys Leu Arg Lys Leu 
    50                  55                  60                  


Gly Leu Ser Asp Asn Glu Ile Gln Arg Leu Pro Pro Glu Ile Ala Asn 
65                  70                  75                  80  


Phe Met Gln Leu Val Glu Leu Asp Val Ser Arg Asn Glu Ile Pro Glu 
                85                  90                  95      


Ile Pro Glu Ser Ile Ser Phe Cys Lys Ala Leu Gln Val Ala Asp Phe 
            100                 105                 110         


Ser Gly Asn Pro Leu Thr Arg Leu Pro Glu Ser Phe Pro Glu Leu Gln 
        115                 120                 125             


Asn Leu Thr Cys Leu Ser Val Asn Asp Ile Ser Leu Gln Ser Leu Pro 
    130                 135                 140                 


Glu Asn Ile Gly Asn Leu Tyr Asn Leu Ala Ser Leu Glu Leu Arg Glu 
145                 150                 155                 160 


Asn Leu Leu Thr Tyr Leu Pro Asp Ser Leu Thr Gln Leu Arg Arg Leu 
                165                 170                 175     


Glu Glu Leu Asp Leu Gly Asn Asn Glu Ile Tyr Asn Leu Asn Gln Leu 
            180                 185                 190         


Glu Pro Ser Tyr Ile 
        195         


<210>  152
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Leu Cys Tyr Val Thr Arg Pro Asp Ala Val Leu Met Glu Val Glu 
1               5                   10                  15      


Val Glu Ala Lys Ala Asn Gly Glu Asp Cys Leu Asn Gln Val Cys Arg 
            20                  25                  30          


Arg Leu Gly Ile Ile Glu Val Asp Tyr Phe Gly Leu Gln Phe Thr Gly 
        35                  40                  45              


Ser Lys Gly Glu Ser Leu Trp Leu Asn Leu Arg Asn Arg Ile Ser Gln 
    50                  55                  60                  


Gln Met Asp Gly Leu Ala Pro Tyr Arg Leu Lys Leu Arg Val Lys Phe 
65                  70                  75                  80  


Phe Val Glu Pro His Leu Ile Leu Gln Glu Gln Thr Arg His Ile Phe 
                85                  90                  95      


Phe Leu His Ile Lys Glu Ala Leu Leu Ala Gly His Leu Leu Cys Ser 
            100                 105                 110         


Pro Glu Gln Ala Val Glu Leu Ser Ala Leu Leu Ala Gln Thr Lys Phe 
        115                 120                 125             


Gly Asp Tyr Asn Gln Asn Thr Ala Lys Tyr Asn Tyr Glu Glu Leu Cys 
    130                 135                 140                 


Ala Lys Glu Leu Ser Ser Ala Thr Leu Asn Ser Ile Val Ala Lys His 
145                 150                 155                 160 


Lys Glu Leu Glu Gly Thr Ser Gln Ala Ser Ala Glu Tyr Gln Val Leu 
                165                 170                 175     


Gln Ile Val Ser Ala Met Glu Asn Tyr Gly Ile Glu Trp His Ser Val 
            180                 185                 190         


Arg Asp Ser Glu Gly Gln Lys Leu Leu Ile Gly Val Gly Pro Glu Gly 
        195                 200                 205             


Ile Ser Ile Cys Lys Asp Asp Phe Ser Pro Ile Asn Arg Ile Ala Tyr 
    210                 215                 220                 


Pro Val Val Gln Met Ala Thr Gln Ser Gly Lys Asn Val Tyr Leu Thr 
225                 230                 235                 240 


Val Thr Lys Glu Ser Gly Asn Ser Ile Val Leu Leu Phe Lys Met Ile 
                245                 250                 255     


Ser Thr Arg Ala Ala Ser Gly Leu Tyr Arg Ala Ile Thr Glu Thr His 
            260                 265                 270         


Ala Phe Tyr Arg Cys Asp Thr Val Thr Ser Ala Val Met Met Gln Tyr 
        275                 280                 285             


Ser Arg Asp Leu Lys Gly His Leu Ala Ser Leu Phe Leu Asn Glu Asn 
    290                 295                 300                 


Ile Asn Leu Gly Lys Lys Tyr Val Phe Asp Ile Lys Arg Thr Ser Lys 
305                 310                 315                 320 


Glu Val Tyr Asp His Ala Arg Arg Ala Leu Tyr Asn Ala Gly Val Val 
                325                 330                 335     


Asp Leu Val Ser Arg Asn Asn Gln Ser Pro Ser His Ser Pro Leu Lys 
            340                 345                 350         


Ser Ser Glu Ser Ser Met Asn Cys Ser Ser Cys Glu Gly Leu Ser Cys 
        355                 360                 365             


Gln Gln Thr Arg Val Leu Gln Glu Lys Leu Arg Lys Leu Lys Glu Ala 
    370                 375                 380                 


Met Leu Cys Met Val Cys Cys Glu Glu Glu Ile Asn Ser Thr Phe Cys 
385                 390                 395                 400 


Pro Cys Gly His Thr Val Cys Cys Glu Ser Cys Ala Ala Gln Leu Gln 
                405                 410                 415     


Ser Cys Pro Val Cys Arg Ser Arg Val Glu His Val Gln His Val Tyr 
            420                 425                 430         


Leu Pro Thr His Thr Ser Leu Leu Asn Leu Thr Val Ile 
        435                 440                 445 


<210>  153
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Glu Asn Tyr Gly Ile Glu Trp His Ser Val Arg Asp Ser Glu Gly 
1               5                   10                  15      


Gln Lys Leu Leu Ile Gly Val Gly Pro Glu Gly Ile Ser Ile Cys Lys 
            20                  25                  30          


Asp Asp Phe Ser Pro Ile Asn Arg Ile Ala Tyr Pro Val Val Gln Met 
        35                  40                  45              


Ala Thr Gln Ser Gly Lys Asn Val Tyr Leu Thr Val Thr Lys Glu Ser 
    50                  55                  60                  


Gly Asn Ser Ile Val Leu Leu Phe Lys Met Ile Ser Thr Arg Ala Ala 
65                  70                  75                  80  


Ser Gly Leu Tyr Arg Ala Ile Thr Glu Thr His Ala Phe Tyr Arg Cys 
                85                  90                  95      


Asp Thr Val Thr Ser Ala Val Met Met Gln Tyr Ser Arg Asp Leu Lys 
            100                 105                 110         


Gly His Leu Ala Ser Leu Phe Leu Asn Glu Asn Ile Asn Leu Gly Lys 
        115                 120                 125             


Lys Tyr Val Phe Asp Ile 
    130                 


<210>  154
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Ser Leu Trp Leu Gly Ala Pro Val Pro Asp Ile Pro Pro Asp Ser 
1               5                   10                  15      


Ala Val Glu Leu Trp Lys Pro Gly Ala Gln Asp Ala Ser Ser Gln Ala 
            20                  25                  30          


Gln Gly Gly Ser Ser Cys Ile Leu Arg Glu Glu Ala Arg Met Pro His 
        35                  40                  45              


Ser Ala Gly Gly Thr Ala Gly Val Gly Leu Glu Ala Ala Glu Pro Thr 
    50                  55                  60                  


Ala Leu Leu Thr Arg Ala Glu Pro Pro Ser Glu Pro Thr Glu Ile Arg 
65                  70                  75                  80  


Pro Gln Lys Arg Lys Lys Gly Pro Ala Pro Lys Met Leu Gly Asn Glu 
                85                  90                  95      


Leu Cys Ser Val Cys Gly Asp Lys Ala Ser Gly Phe His Tyr Asn Val 
            100                 105                 110         


Leu Ser Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Val Ile Lys 
        115                 120                 125             


Gly Ala His Tyr Ile Cys His Ser Gly Gly His Cys Pro Met Asp Thr 
    130                 135                 140                 


Tyr Met Arg Arg Lys Cys Gln Glu Cys Arg Leu Arg Lys Cys Arg Gln 
145                 150                 155                 160 


Ala Gly Met Arg Glu Glu Cys Val Leu Ser Glu Glu Gln Ile Arg Leu 
                165                 170                 175     


Lys Lys Leu Lys Arg Gln Glu Glu Glu Gln Ala His Ala Thr Ser Leu 
            180                 185                 190         


Pro Pro Arg Ala Ser Ser Pro Pro Gln Ile Leu Pro Gln Leu Ser Pro 
        195                 200                 205             


Glu Gln Leu Gly Met Ile Glu Lys Leu Val Ala Ala Gln Gln Gln Cys 
    210                 215                 220                 


Asn Arg Arg Ser Phe Ser Asp Arg Leu Arg Val Thr Pro Trp Pro Met 
225                 230                 235                 240 


Ala Pro Asp Pro His Ser Arg Glu Ala Arg Gln Gln Arg Phe Ala His 
                245                 250                 255     


Phe Thr Glu Leu Ala Ile Val Ser Val Gln Glu Ile Val Asp Phe Ala 
            260                 265                 270         


Lys Gln Leu Pro Gly Phe Leu Gln Leu Ser Arg Glu Asp Gln Ile Ala 
        275                 280                 285             


Leu Leu Lys Thr Ser Ala Ile Glu Val Met Leu Leu Glu Thr Ser Arg 
    290                 295                 300                 


Arg Tyr Asn Pro Gly Ser Glu Ser Ile Thr Phe Leu Lys Asp Phe Ser 
305                 310                 315                 320 


Tyr Asn Arg Glu Asp Phe Ala Lys Ala Gly Leu Gln Val Glu Phe Ile 
                325                 330                 335     


Asn Pro Ile Phe Glu Phe Ser Arg Ala Met Asn Glu Leu Gln Leu Asn 
            340                 345                 350         


Asp Ala Glu Phe Ala Leu Leu Ile Ala Ile Ser Ile Phe Ser Ala Asp 
        355                 360                 365             


Arg Pro Asn Val Gln Asp Gln Leu Gln Val Glu Arg Leu Gln His Thr 
    370                 375                 380                 


Tyr Val Glu Ala Leu His Ala Tyr Val Ser Ile His His Pro His Asp 
385                 390                 395                 400 


Arg Leu Met Phe Pro Arg Met Leu Met Lys Leu Val Ser Leu Arg Thr 
                405                 410                 415     


Leu Ser Ser Val His Ser Glu Gln Val Phe Ala Leu Arg Leu Gln Asp 
            420                 425                 430         


Lys Lys Leu Pro Pro Leu Leu Ser Glu Ile Trp Asp Val His Glu 
        435                 440                 445         


<210>  155
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Ser Leu Trp Leu Gly Ala Pro Val Pro Asp Ile Pro Pro Asp Ser 
1               5                   10                  15      


Ala Val Glu Leu Trp Lys Pro Gly Ala Gln Asp Ala Ser Ser Gln Ala 
            20                  25                  30          


Gln Gly Gly Ser Ser Cys Ile Leu Arg Glu Glu Ala Arg Met Pro His 
        35                  40                  45              


Ser Ala Gly Gly Thr Ala Gly Val Gly Leu Glu Ala Ala Glu Pro Thr 
    50                  55                  60                  


Ala Leu Leu Thr Arg Ala Glu Pro Pro Ser Glu Pro Thr Glu Ile Arg 
65                  70                  75                  80  


Pro Gln Lys Arg Lys Lys Gly Pro Ala Pro Lys Met Leu Gly Asn Glu 
                85                  90                  95      


Leu Cys Ser Val Cys Gly Asp Lys Ala Ser Gly Phe His Tyr Asn Val 
            100                 105                 110         


Leu Ser Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Val Ile Lys 
        115                 120                 125             


Gly Ala His Tyr Ile Cys His Ser Gly Gly His Cys Pro Met Asp Thr 
    130                 135                 140                 


Tyr Met Arg Arg Lys Cys Gln Glu Cys Arg Leu Arg Lys Cys Arg Gln 
145                 150                 155                 160 


Ala Gly Met Arg Glu Glu Cys Val Leu Ser Glu Glu Gln Ile Arg Leu 
                165                 170                 175     


Lys Lys Leu Lys Arg Gln Glu Glu Glu Gln Ala His Ala Thr Ser Leu 
            180                 185                 190         


Pro Pro Arg Ala Ser Ser Pro Pro Gln Ile Leu Pro Gln Leu Ser Pro 
        195                 200                 205             


Glu Gln Leu Gly Met Ile Glu Lys Leu Val Ala Ala Gln Gln Gln Cys 
    210                 215                 220                 


Asn Arg Arg Ser Phe Ser Asp Arg Leu Arg Val Thr Val Met Leu Leu 
225                 230                 235                 240 


Glu Thr Ser Arg Arg Tyr Asn Pro Gly Ser Glu Ser Ile Thr Phe Leu 
                245                 250                 255     


Lys Asp Phe Ser Tyr Asn Arg Glu Asp Phe Ala Lys Ala Gly Leu Gln 
            260                 265                 270         


Val Glu Phe Ile Asn Pro Ile Phe Glu Phe Ser Arg Ala Met Asn Glu 
        275                 280                 285             


Leu Gln Leu Asn Asp Ala Glu Phe Ala Leu Leu Ile Ala Ile Ser Ile 
    290                 295                 300                 


Phe Ser Ala Asp Arg Pro Asn Val Gln Asp Gln Leu Gln Val Glu Arg 
305                 310                 315                 320 


Leu Gln His Thr Tyr Val Glu Ala Leu His Ala Tyr Val Ser Ile His 
                325                 330                 335     


His Pro His Asp Arg Leu Met Phe Pro Arg Met Leu Met Lys Leu Val 
            340                 345                 350         


Ser Leu Arg Thr Leu Ser Ser Val His Ser Glu Gln Val Phe Ala Leu 
        355                 360                 365             


Arg Leu Gln Asp Lys Lys Leu Pro Pro Leu Leu Ser Glu Ile Trp Asp 
    370                 375                 380                 


Val His Glu 
385         


<210>  156
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Pro His Ser Ala Gly Gly Thr Ala Gly Val Gly Leu Glu Ala Ala 
1               5                   10                  15      


Glu Pro Thr Ala Leu Leu Thr Arg Ala Glu Pro Pro Ser Glu Pro Thr 
            20                  25                  30          


Glu Ile Arg Pro Gln Lys Arg Lys Lys Gly Pro Ala Pro Lys Met Leu 
        35                  40                  45              


Gly Asn Glu Leu Cys Ser Val Cys Gly Asp Lys Ala Ser Gly Phe His 
    50                  55                  60                  


Tyr Asn Val Leu Ser Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser 
65                  70                  75                  80  


Val Ile Lys Gly Ala His Tyr Ile Cys His Ser Gly Gly His Cys Pro 
                85                  90                  95      


Met Asp Thr Tyr Met Arg Arg Lys Cys Gln Glu Cys Arg Leu Arg Lys 
            100                 105                 110         


Cys Arg Gln Ala Gly Met Arg Glu Glu Cys Val Leu Ser Glu Glu Gln 
        115                 120                 125             


Ile Arg Leu Lys Lys Leu Lys Arg Gln Glu Glu Glu Gln Ala His Ala 
    130                 135                 140                 


Thr Ser Leu Pro Pro Arg Ala Ser Ser Pro Pro Gln Ile Leu Pro Gln 
145                 150                 155                 160 


Leu Ser Pro Glu Gln Leu Gly Met Ile Glu Lys Leu Val Ala Ala Gln 
                165                 170                 175     


Gln Gln Cys Asn Arg Arg Ser Phe Ser Asp Arg Leu Arg Val Thr Pro 
            180                 185                 190         


Trp Pro Met Ala Pro Asp Pro His Ser Arg Glu Ala Arg Gln Gln Arg 
        195                 200                 205             


Phe Ala His Phe Thr Glu Leu Ala Ile Val Ser Val Gln Glu Ile Val 
    210                 215                 220                 


Asp Phe Ala Lys Gln Leu Pro Gly Phe Leu Gln Leu Ser Arg Glu Asp 
225                 230                 235                 240 


Gln Ile Ala Leu Leu Lys Thr Ser Ala Ile Glu Val Met Leu Leu Glu 
                245                 250                 255     


Thr Ser Arg Arg Tyr Asn Pro Gly Ser Glu Ser Ile Thr Phe Leu Lys 
            260                 265                 270         


Asp Phe Ser Tyr Asn Arg Glu Asp Phe Ala Lys Ala Gly Leu Gln Val 
        275                 280                 285             


Glu Phe Ile Asn Pro Ile Phe Glu Phe Ser Arg Ala Met Asn Glu Leu 
    290                 295                 300                 


Gln Leu Asn Asp Ala Glu Phe Ala Leu Leu Ile Ala Ile Ser Ile Phe 
305                 310                 315                 320 


Ser Ala Asp Arg Pro Asn Val Gln Asp Gln Leu Gln Val Glu Arg Leu 
                325                 330                 335     


Gln His Thr Tyr Val Glu Ala Leu His Ala Tyr Val Ser Ile His His 
            340                 345                 350         


Pro His Asp Arg Leu Met Phe Pro Arg Met Leu Met Lys Leu Val Ser 
        355                 360                 365             


Leu Arg Thr Leu Ser Ser Val His Ser Glu Gln Val Phe Ala Leu Arg 
    370                 375                 380                 


Leu Gln Asp Lys Lys Leu Pro Pro Leu Leu Ser Glu Ile Trp Asp Val 
385                 390                 395                 400 


His Glu 
        


<210>  157
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Ala Thr Gln Arg Lys His Leu Val Lys Asp Phe Asn Pro Tyr Ile 
1               5                   10                  15      


Thr Cys Tyr Ile Cys Lys Gly Tyr Leu Ile Lys Pro Thr Thr Val Thr 
            20                  25                  30          


Glu Cys Leu His Thr Phe Cys Lys Thr Cys Ile Val Gln His Phe Glu 
        35                  40                  45              


Asp Ser Asn Asp Cys Pro Arg Cys Gly Asn Gln Val His Glu Thr Asn 
    50                  55                  60                  


Pro Leu Glu Met Leu Arg Leu Asp Asn Thr Leu Glu Glu Ile Ile Phe 
65                  70                  75                  80  


Lys Leu Val Pro Gly Leu Arg Glu Gln Glu Leu Glu Arg Glu Ser Glu 
                85                  90                  95      


Phe Trp Lys Lys Asn Lys Pro Gln Glu Asn Gly Gln Asp Asp Thr Ser 
            100                 105                 110         


Lys Ala Asp Lys Pro Lys Val Asp Glu Glu Gly Asp Glu Asn Glu Asp 
        115                 120                 125             


Asp Lys Asp Tyr His Arg Ser Asp Pro Gln Ile Ala Ile Cys Leu Asp 
    130                 135                 140                 


Cys Leu Arg Asn Asn Gly Gln Ser Gly Asp Asn Val Val Lys Gly Leu 
145                 150                 155                 160 


Met Lys Lys Phe Ile Arg Cys Ser Thr Arg Val Thr Val Gly Thr Ile 
                165                 170                 175     


Lys Lys Phe Leu Ser Leu Lys Leu Lys Leu Pro Ser Ser Tyr Glu Leu 
            180                 185                 190         


Asp Val Leu Cys Asn Gly Glu Ile Met Gly Lys Asp His Thr Met Glu 
        195                 200                 205             


Phe Ile Tyr Met Thr Arg Trp Arg Leu Arg Gly Glu Asn Phe Arg Cys 
    210                 215                 220                 


Leu Asn Cys Ser Ala Ser Gln Val Cys Ser Gln Asp Gly Pro Leu Tyr 
225                 230                 235                 240 


Gln Ser Tyr Pro Met Val Leu Gln Tyr Arg Pro Arg Ile Asp Phe Gly 
                245                 250                 255     


<210>  158
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Ala Thr Gln Arg Lys His Leu Val Lys Asp Phe Asn Pro Tyr Ile 
1               5                   10                  15      


Thr Cys Tyr Ile Cys Lys Gly Tyr Leu Ile Lys Pro Thr Thr Val Thr 
            20                  25                  30          


Glu Cys Leu His Thr Ser Ala Glu Ser Tyr Trp Met Ser Thr Trp Met 
        35                  40                  45              


Ser 
    


<210>  159
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Ser Gly Val Val Pro Thr Ala Pro Glu Gln Pro Ala Gly Glu Met 
1               5                   10                  15      


Glu Asn Gln Thr Lys Pro Pro Asp Pro Arg Pro Asp Ala Pro Pro Glu 
            20                  25                  30          


Tyr Asn Ser His Phe Leu Pro Gly Pro Pro Gly Thr Ala Val Pro Pro 
        35                  40                  45              


Pro Thr Gly Tyr Pro Gly Gly Leu Pro Met Gly Tyr Tyr Ser Pro Gln 
    50                  55                  60                  


Gln Pro Ser Thr Phe Pro Leu Tyr Gln Pro Val Gly Gly Ile His Pro 
65                  70                  75                  80  


Val Arg Tyr Gln Pro Gly Lys Tyr Pro Met Pro Asn Gln Ser Val Pro 
                85                  90                  95      


Ile Thr Trp Met Pro Gly Pro Thr Pro Met Ala Asn Cys Pro Pro Gly 
            100                 105                 110         


Leu Glu Tyr Leu Val Gln Leu Asp Asn Ile His Val Leu Gln His Phe 
        115                 120                 125             


Glu Pro Leu Glu Met Met Thr Cys Phe Glu Thr Asn Asn Arg Tyr Asp 
    130                 135                 140                 


Ile Lys Asn Asn Ser Asp Gln Met Val Tyr Ile Val Thr Glu Asp Thr 
145                 150                 155                 160 


Asp Asp Phe Thr Arg Asn Ala Tyr Arg Thr Leu Arg Pro Phe Val Leu 
                165                 170                 175     


Arg Val Thr Asp Cys Met Gly Arg Glu Ile Met Thr Met Gln Arg Pro 
            180                 185                 190         


Phe Arg Cys Thr Cys Cys Cys Phe Cys Cys Pro Ser Ala Arg Gln Glu 
        195                 200                 205             


Leu Glu Val Gln Cys Pro Pro Gly Val Thr Ile Gly Phe Val Ala Glu 
    210                 215                 220                 


His Trp Asn Leu Cys Arg Ala Val Tyr Ser Ile Gln Asn Glu Lys Lys 
225                 230                 235                 240 


Glu Asn Val Met Arg Val Arg Gly Pro Cys Ser Thr Tyr Gly Cys Gly 
                245                 250                 255     


Ser Asp Ser Val Phe Glu Val Lys Ser Leu Asp Gly Ile Ser Asn Ile 
            260                 265                 270         


Gly Ser Ile Ile Arg Lys Trp Asn Gly Leu Leu Ser Ala Met Ala Asp 
        275                 280                 285             


Ala Asp His Phe Asp Ile His Phe Pro Leu Asp Leu Asp Val Lys Met 
    290                 295                 300                 


Lys Ala Met Ile Phe Gly Ala Cys Phe Leu Ile Asp Phe Met Tyr Phe 
305                 310                 315                 320 


Glu Arg Ser Pro Pro Gln Arg Ser Arg 
                325                 


<210>  160
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Glu Asn Gln Thr Lys Pro Pro Asp Pro Arg Pro Asp Ala Pro Pro 
1               5                   10                  15      


Glu Tyr Asn Ser His Phe Leu Pro Gly Pro Pro Gly Thr Ala Val Pro 
            20                  25                  30          


Pro Pro Thr Gly Tyr Pro Gly Gly Leu Pro Met Gly Tyr Tyr Ser Pro 
        35                  40                  45              


Gln Gln Pro Ser Thr Phe Pro Leu Tyr Gln Pro Val Gly Gly Ile His 
    50                  55                  60                  


Pro Val Arg Tyr Gln Pro Gly Lys Tyr Pro Met Pro Asn Gln Ser Val 
65                  70                  75                  80  


Pro Ile Thr Trp Met Pro Gly Pro Thr Pro Met Ala Asn Cys Pro Pro 
                85                  90                  95      


Gly Leu Glu Tyr Leu Val Gln Leu Glu Val Gln Cys Pro Pro Gly Val 
            100                 105                 110         


Thr Ile Gly Phe Val Ala Glu His Trp Asn Leu Cys Arg Ala Val Tyr 
        115                 120                 125             


Ser Ile Gln Asn Glu Lys Lys Glu Asn Val Met Arg Val Arg Gly Pro 
    130                 135                 140                 


Cys Ser Thr Tyr Gly Cys Gly Ser Asp Ser Val Phe Glu Val Lys Ser 
145                 150                 155                 160 


Leu Asp Gly Ile Ser Asn Ile Gly Ser Ile Ile Arg Lys Trp Asn Gly 
                165                 170                 175     


Leu Leu Ser Ala Met Ala Asp Ala Asp His Phe Asp Ile His Phe Pro 
            180                 185                 190         


Leu Asp Leu Asp Val Lys Met Lys Ala Met Ile Phe Gly Ala Cys Phe 
        195                 200                 205             


Leu Ile Asp Phe Met Tyr Phe Glu Arg Ser Pro Pro Gln Arg Ser Arg 
    210                 215                 220                 


<210>  161
<211>  1283
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Ser Leu Met Val Ser Ala Gly Arg Gly Leu Gly Ala Val Trp Ser 
1               5                   10                  15      


Pro Thr His Val Gln Val Thr Val Leu Gln Ala Arg Gly Leu Arg Ala 
            20                  25                  30          


Lys Gly Pro Gly Gly Thr Ser Asp Ala Tyr Ala Val Ile Gln Val Gly 
        35                  40                  45              


Lys Glu Lys Tyr Ala Thr Ser Val Ser Glu Arg Ser Leu Gly Ala Pro 
    50                  55                  60                  


Val Trp Arg Glu Glu Ala Thr Phe Glu Leu Pro Ser Leu Leu Ser Ser 
65                  70                  75                  80  


Gly Pro Ala Ala Ala Ala Thr Leu Gln Leu Thr Val Leu His Arg Ala 
                85                  90                  95      


Leu Leu Gly Leu Asp Lys Phe Leu Gly Arg Ala Glu Val Asp Leu Arg 
            100                 105                 110         


Asp Leu His Arg Asp Gln Gly Arg Arg Lys Thr Gln Trp Tyr Lys Leu 
        115                 120                 125             


Lys Ser Lys Pro Gly Lys Lys Asp Lys Glu Arg Gly Glu Ile Glu Val 
    130                 135                 140                 


Asp Ile Gln Phe Met Arg Asn Asn Met Thr Ala Ser Met Phe Asp Leu 
145                 150                 155                 160 


Ser Met Lys Asp Lys Ser Arg Asn Pro Phe Gly Lys Leu Lys Asp Lys 
                165                 170                 175     


Ile Lys Gly Lys Asn Lys Asp Ser Gly Ser Asp Thr Ala Ser Ala Ile 
            180                 185                 190         


Ile Pro Ser Thr Thr Pro Ser Val Asp Ser Asp Asp Glu Ser Val Val 
        195                 200                 205             


Lys Asp Lys Lys Lys Lys Ser Lys Ile Lys Thr Leu Leu Ser Lys Ser 
    210                 215                 220                 


Asn Leu Gln Lys Thr Pro Leu Ser Gln Ser Met Ser Val Leu Pro Thr 
225                 230                 235                 240 


Ser Lys Pro Glu Lys Val Leu Leu Arg Pro Gly Asp Phe Gln Ser Gln 
                245                 250                 255     


Trp Asp Glu Asp Asp Asn Glu Asp Glu Ser Ser Ser Ala Ser Asp Val 
            260                 265                 270         


Met Ser His Lys Arg Thr Ala Ser Thr Asp Leu Lys Gln Leu Asn Gln 
        275                 280                 285             


Val Asn Phe Thr Leu Pro Lys Lys Glu Gly Leu Ser Phe Leu Gly Gly 
    290                 295                 300                 


Leu Arg Ser Lys Asn Asp Val Leu Ser Arg Ser Asn Val Cys Ile Asn 
305                 310                 315                 320 


Gly Asn His Val Tyr Leu Glu Gln Pro Glu Ala Lys Gly Glu Ile Lys 
                325                 330                 335     


Asp Ser Ser Pro Ser Ser Ser Pro Ser Pro Lys Gly Phe Arg Lys Lys 
            340                 345                 350         


His Leu Phe Ser Ser Thr Glu Asn Leu Ala Ala Gly Ser Trp Lys Glu 
        355                 360                 365             


Pro Ala Glu Gly Gly Gly Leu Ser Ser Asp Arg Gln Leu Ser Glu Ser 
    370                 375                 380                 


Ser Thr Lys Asp Ser Leu Lys Ser Met Thr Leu Pro Ser Tyr Arg Pro 
385                 390                 395                 400 


Ala Pro Leu Val Ser Gly Asp Leu Arg Glu Asn Met Ala Pro Ala Asn 
                405                 410                 415     


Ser Glu Ala Thr Lys Glu Ala Lys Glu Ser Lys Lys Pro Glu Ser Arg 
            420                 425                 430         


Arg Ser Ser Leu Leu Ser Leu Met Thr Gly Lys Lys Asp Val Ala Lys 
        435                 440                 445             


Gly Ser Glu Gly Glu Asn Pro Leu Thr Val Pro Gly Arg Glu Lys Glu 
    450                 455                 460                 


Gly Met Leu Met Gly Val Lys Pro Gly Glu Asp Ala Ser Gly Pro Ala 
465                 470                 475                 480 


Glu Asp Leu Val Arg Arg Ser Glu Lys Asp Thr Ala Ala Val Val Ser 
                485                 490                 495     


Arg Gln Gly Ser Ser Leu Asn Leu Phe Glu Asp Val Gln Ile Thr Glu 
            500                 505                 510         


Pro Glu Ala Glu Pro Glu Ser Lys Ser Glu Pro Arg Pro Pro Ile Ser 
        515                 520                 525             


Ser Pro Arg Ala Pro Gln Thr Arg Ala Val Lys Pro Arg Leu Glu Val 
    530                 535                 540                 


Ser Pro Glu Ala Gln Pro Thr Ala Arg Leu Pro Ser Pro Thr Asp Ser 
545                 550                 555                 560 


Pro Ser Ser Leu Pro Pro Leu Pro Ser Ser Ser Gly Gln Ala Ser Val 
                565                 570                 575     


Pro Ser Glu Leu Gly His Gly Ala Asp Thr Gln Ser Ser Glu Ser Pro 
            580                 585                 590         


Ser Val Phe Ser Ser Leu Ser Ser Pro Ile Ala Ala Pro Ile Ser Thr 
        595                 600                 605             


Ser Thr Pro Ile Glu Ser Trp Pro Leu Val Asp Arg Gly Gln Ala Lys 
    610                 615                 620                 


Ser Glu Gly Pro Pro Leu Leu Pro Lys Ala Glu Leu Gln Thr Glu Ser 
625                 630                 635                 640 


Leu Thr Pro Val Pro Asn Ser Gly Ser Ser Ala Leu Gly Ser Leu Phe 
                645                 650                 655     


Lys Gln Pro Ser Phe Pro Ala Asn Lys Gly Thr Glu Asp Ser Leu Met 
            660                 665                 670         


Gly Arg Thr Arg Glu Thr Gly Thr Glu Lys Asn Thr Ser Ser Leu Glu 
        675                 680                 685             


Leu Glu Glu Ser Leu Pro Glu Gln Pro Glu Thr Gly Arg Gln Glu Glu 
    690                 695                 700                 


Glu Leu Pro Arg Phe Pro Cys Lys Lys Gln Asp Tyr Ser Pro Ser Ser 
705                 710                 715                 720 


Gly Glu Ala Gln Glu Val Pro Phe Ala Leu Ser Leu Ser Ser Asp Gly 
                725                 730                 735     


Ala Val Ser Pro Val Gly Glu Leu Ala Ala Gly Gly Asp Arg Asp Leu 
            740                 745                 750         


Glu Ser Gln Ala Gly Ser Leu Val Glu Ser Lys Ala Arg Asp Ala Ala 
        755                 760                 765             


Glu Glu Val Ala Pro Pro Leu Pro Met Gly Ala Ser Val Pro Ser Ile 
    770                 775                 780                 


Asp Ser Met Met Arg Lys Leu Glu Glu Met Gly Leu Asn Leu Arg Lys 
785                 790                 795                 800 


Asp Gln Lys Lys Thr Lys Lys Arg Val Ser Phe Ser Glu Gln Leu Phe 
                805                 810                 815     


Thr Glu Glu Ala Val Ala Gly Ala Ala Leu Leu Val Glu Gly His Ser 
            820                 825                 830         


Ser Cys Pro Gln Glu Leu Asn Pro Ala Trp Ser Val Ala Gly Asn Ala 
        835                 840                 845             


Ser Asp Gly Glu Pro Pro Glu Ser Pro His Ala Glu Asp Ser Glu Arg 
    850                 855                 860                 


Glu Ser Val Thr Thr Pro Gly Pro Ala Thr Cys Gly Ala Pro Ala Ser 
865                 870                 875                 880 


Pro Ala Asp His Leu Leu Leu Pro Ser Gln Glu Glu Ser Phe Ser Glu 
                885                 890                 895     


Val Pro Met Ser Glu Ala Ser Ser Ala Lys Asp Thr Pro Leu Phe Arg 
            900                 905                 910         


Met Glu Gly Glu Asp Ala Leu Val Thr Gln Tyr Gln Ser Lys Ala Ser 
        915                 920                 925             


Asp His Glu Gly Leu Leu Ser Asp Pro Leu Ser Asp Leu Gln Leu Val 
    930                 935                 940                 


Ser Asp Phe Lys Ser Pro Ile Met Ala Asp Leu Asn Leu Ser Leu Pro 
945                 950                 955                 960 


Ser Ile Pro Glu Val Ala Ser Asp Asp Glu Arg Ile Asp Gln Val Glu 
                965                 970                 975     


Asp Asp Gly Asp Gln Val Glu Asp Asp Gly Glu Thr Ala Lys Ser Ser 
            980                 985                 990         


Thr Leu Asp Ile Gly Ala Leu Ser  Leu Gly Leu Val Val  Pro Cys Pro 
        995                 1000                 1005             


Glu Arg  Gly Lys Gly Pro Ser  Gly Glu Ala Asp Arg  Leu Val Leu 
    1010                 1015                 1020             


Gly Glu  Gly Leu Cys Asp Phe  Arg Leu Gln Ala Pro  Gln Ala Ser 
    1025                 1030                 1035             


Val Thr  Ala Pro Ser Glu Gln  Thr Thr Glu Phe Gly  Ile His Lys 
    1040                 1045                 1050             


Pro His  Leu Gly Lys Ser Ser  Ser Leu Asp Lys Gln  Leu Pro Gly 
    1055                 1060                 1065             


Pro Ser  Gly Gly Glu Glu Glu  Lys Pro Met Gly Asn  Gly Ser Pro 
    1070                 1075                 1080             


Ser Pro  Pro Pro Gly Thr Ser  Leu Asp Asn Pro Val  Pro Ser Pro 
    1085                 1090                 1095             


Ser Pro  Ser Glu Ile Phe Pro  Val Thr His Ser Phe  Pro Ser Ser 
    1100                 1105                 1110             


Ala His  Ser Asp Thr His His  Thr Ser Thr Ala Glu  Ser Gln Lys 
    1115                 1120                 1125             


Lys Ala  Thr Ala Glu Gly Ser  Ala Gly Arg Val Glu  Asn Phe Gly 
    1130                 1135                 1140             


Lys Arg  Lys Pro Leu Leu Gln  Ala Trp Val Ser Pro  Ser Glu Thr 
    1145                 1150                 1155             


His Pro  Val Ser Ala Gln Pro  Gly Ala Gly Thr Gly  Ser Ala Lys 
    1160                 1165                 1170             


His Arg  Leu His Pro Val Lys  Pro Met Asn Ala Met  Ala Thr Lys 
    1175                 1180                 1185             


Val Ala  Asn Cys Ser Leu Gly  Thr Ala Thr Ile Ile  Ser Glu Asn 
    1190                 1195                 1200             


Leu Asn  Asn Glu Val Met Met  Lys Lys Tyr Ser Pro  Ser Asp Pro 
    1205                 1210                 1215             


Ala Phe  Ala Tyr Ala Gln Leu  Thr His Asp Glu Leu  Ile Gln Leu 
    1220                 1225                 1230             


Val Leu  Lys Gln Lys Glu Thr  Ile Ser Lys Lys Glu  Phe Gln Val 
    1235                 1240                 1245             


Arg Glu  Leu Glu Asp Tyr Ile  Asp Asn Leu Leu Val  Arg Val Met 
    1250                 1255                 1260             


Glu Glu  Thr Pro Asn Ile Leu  Arg Ile Pro Thr Gln  Val Gly Lys 
    1265                 1270                 1275             


Lys Ala  Gly Lys Met 
    1280             


<210>  162
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Ser Leu Met Val Ser Ala Gly Arg Gly Leu Gly Ala Val Trp Ser 
1               5                   10                  15      


Pro Thr His Val Gln Val Thr Val Leu Gln Ala Arg Gly Leu Arg Ala 
            20                  25                  30          


Lys Gly Pro Gly Gly Thr Ser Asp Ala Tyr Ala Val Ile Gln Val Gly 
        35                  40                  45              


Lys Glu Lys Tyr Ala Thr Ser Val Ser Glu Arg Ser Leu Gly Ala Pro 
    50                  55                  60                  


Val Trp Arg Glu Glu Ala Thr Phe Glu Leu Pro Ser Leu Leu Ser Ser 
65                  70                  75                  80  


Gly Pro Ala Ala Ala Ala Thr Leu Gln Leu Thr Val Leu His Arg Ala 
                85                  90                  95      


Leu Leu Gly Leu Asp Lys Phe Leu Gly Arg Ala Glu Val Asp Leu Arg 
            100                 105                 110         


Asp Leu His Arg Asp Gln Gly Arg Arg Lys Thr Gln Trp Tyr Lys Leu 
        115                 120                 125             


Lys Ser Lys Pro Gly Lys Lys Asp Lys Glu Arg Gly Glu Ile Glu Val 
    130                 135                 140                 


Asp Ile Gln Phe Met Arg Asn Asn Met Thr Ala Ser Met Phe Asp Leu 
145                 150                 155                 160 


Ser Met Lys Asp Lys Ser Arg Asn Pro Phe Gly Lys Leu Lys Asp Lys 
                165                 170                 175     


Ile Lys Gly Lys Asn Lys Asp Ser Gly Ser Asp Thr Ala Ser Ala Ile 
            180                 185                 190         


Ile Pro Ser Thr Thr Pro Ser Val Asp Ser Asp Asp Glu Ser Val Val 
        195                 200                 205             


Lys Asp Lys Lys Lys Lys Ser Lys Ile Lys Thr Leu Leu Ser Lys Ser 
    210                 215                 220                 


Asn Leu Gln Lys Thr Pro Leu Ser Gln Ser Met Ser Val Leu Pro Thr 
225                 230                 235                 240 


Ser Lys Pro Glu Lys Val Leu Leu Arg Pro Gly Asp Phe Gln Ser Gln 
                245                 250                 255     


Trp Asp Glu Asp Asp Asn Glu Asp Glu Ser Ser Ser Ala Ser Asp Val 
            260                 265                 270         


Met Ser His Lys Arg Thr Ala Ser Thr Asp Leu Lys Gln Leu Asn Gln 
        275                 280                 285             


Val Asn Phe Thr Leu Pro Lys Lys Glu Gly Leu Ser Phe Leu Gly Gly 
    290                 295                 300                 


Leu Arg Ser Lys Asn Asp Val Leu Ser Arg Ser Asn Val Cys Ile Asn 
305                 310                 315                 320 


Gly Asn His Val Tyr Leu Glu Gln Pro Glu Ala Lys Gly Glu Ile Lys 
                325                 330                 335     


Asp Ser Ser Pro Ser Ser Ser Pro Ser Pro Lys Gly Phe Arg Lys Lys 
            340                 345                 350         


His Leu Phe Ser Ser Thr Glu Asn Leu Ala Ala Gly Ser Trp Lys Glu 
        355                 360                 365             


Pro Ala Glu Gly Gly Gly Leu Ser Ser Asp Arg Gln Leu Ser Glu Ser 
    370                 375                 380                 


Ser Thr Lys Asp Ser Leu Lys Ser Met Thr Leu Pro Ser Tyr Arg Pro 
385                 390                 395                 400 


Ala Pro Leu Val Ser Gly Asp Leu Arg Glu Asn Met Ala Pro Ala Asn 
                405                 410                 415     


Ser Glu Ala Thr Lys Glu Ala Lys Glu Ser Lys Lys Pro Glu Ser Arg 
            420                 425                 430         


Arg Ser Ser Leu Leu Ser Leu Met Thr Gly Lys Lys Asp Val Ala Lys 
        435                 440                 445             


Gly Ser Glu Gly Glu Asn Pro Leu Thr Val Pro Gly Arg Glu Lys Glu 
    450                 455                 460                 


Gly Met Leu Met Gly Val Lys Pro Gly Glu Asp Ala Ser Gly Pro Ala 
465                 470                 475                 480 


Glu Asp Leu Val Arg Arg Ser Glu Lys Asp Thr Ala Ala Val Val Ser 
                485                 490                 495     


Arg Gln Gly Ser Ser Leu Asn Leu Phe Glu Asp Val Gln Ile Thr Glu 
            500                 505                 510         


Pro Glu Ala Glu Pro Glu Ser Lys Ser Glu Pro Arg Pro Pro Ile Ser 
        515                 520                 525             


Ser Pro Arg Ala Pro Gln Thr Arg Ala Val Lys Pro Arg Leu His Pro 
    530                 535                 540                 


Val Lys Pro Met Asn Ala Met Ala Thr Lys Val Ala Asn Cys Ser Leu 
545                 550                 555                 560 


Gly Thr Ala Thr Ile Ile Ser Glu Asn Leu Asn Asn Glu Val Met Met 
                565                 570                 575     


Lys Lys Tyr Ser Pro Ser Asp Pro Ala Phe Ala Tyr Ala Gln Leu Thr 
            580                 585                 590         


His Asp Glu Leu Ile Gln Leu Val Leu Lys Gln Lys Glu Thr Ile Ser 
        595                 600                 605             


Lys Lys Glu Phe Gln Val Arg Glu Leu Glu Asp Tyr Ile Asp Asn Leu 
    610                 615                 620                 


Leu Val Arg Val Met Glu Glu Thr Pro Asn Ile Leu Arg Ile Pro Thr 
625                 630                 635                 640 


Gln Val Gly Lys Lys Ala Gly Lys Met 
                645                 


<210>  163
<211>  612
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Gly Arg Thr Arg Glu Thr Gly Thr Glu Lys Asn Thr Ser Ser Leu 
1               5                   10                  15      


Glu Leu Glu Glu Ser Leu Pro Glu Gln Pro Glu Thr Gly Arg Gln Glu 
            20                  25                  30          


Glu Glu Leu Pro Arg Phe Pro Cys Lys Lys Gln Asp Tyr Ser Pro Ser 
        35                  40                  45              


Ser Gly Glu Ala Gln Glu Val Pro Phe Ala Leu Ser Leu Ser Ser Asp 
    50                  55                  60                  


Gly Ala Val Ser Pro Val Gly Glu Leu Ala Ala Gly Gly Asp Arg Asp 
65                  70                  75                  80  


Leu Glu Ser Gln Ala Gly Ser Leu Val Glu Ser Lys Ala Arg Asp Ala 
                85                  90                  95      


Ala Glu Glu Val Ala Pro Pro Leu Pro Met Gly Ala Ser Val Pro Ser 
            100                 105                 110         


Ile Asp Ser Met Met Arg Lys Leu Glu Glu Met Gly Leu Asn Leu Arg 
        115                 120                 125             


Lys Asp Gln Lys Lys Thr Lys Lys Arg Val Ser Phe Ser Glu Gln Leu 
    130                 135                 140                 


Phe Thr Glu Glu Ala Val Ala Gly Ala Ala Leu Leu Val Glu Gly His 
145                 150                 155                 160 


Ser Ser Cys Pro Gln Glu Leu Asn Pro Ala Trp Ser Val Ala Gly Asn 
                165                 170                 175     


Ala Ser Asp Gly Glu Pro Pro Glu Ser Pro His Ala Glu Asp Ser Glu 
            180                 185                 190         


Arg Glu Ser Val Thr Thr Pro Gly Pro Ala Thr Cys Gly Ala Pro Ala 
        195                 200                 205             


Ser Pro Ala Asp His Leu Leu Leu Pro Ser Gln Glu Glu Ser Phe Ser 
    210                 215                 220                 


Glu Val Pro Met Ser Glu Ala Ser Ser Ala Lys Asp Thr Pro Leu Phe 
225                 230                 235                 240 


Arg Met Glu Gly Glu Asp Ala Leu Val Thr Gln Tyr Gln Ser Lys Ala 
                245                 250                 255     


Ser Asp His Glu Gly Leu Leu Ser Asp Pro Leu Ser Asp Leu Gln Leu 
            260                 265                 270         


Val Ser Asp Phe Lys Ser Pro Ile Met Ala Asp Leu Asn Leu Ser Leu 
        275                 280                 285             


Pro Ser Ile Pro Glu Val Ala Ser Asp Asp Glu Arg Ile Asp Gln Val 
    290                 295                 300                 


Glu Asp Asp Gly Asp Gln Val Glu Asp Asp Gly Glu Thr Ala Lys Ser 
305                 310                 315                 320 


Ser Thr Leu Asp Ile Gly Ala Leu Ser Leu Gly Leu Val Val Pro Cys 
                325                 330                 335     


Pro Glu Arg Gly Lys Gly Pro Ser Gly Glu Ala Asp Arg Leu Val Leu 
            340                 345                 350         


Gly Glu Gly Leu Cys Asp Phe Arg Leu Gln Ala Pro Gln Ala Ser Val 
        355                 360                 365             


Thr Ala Pro Ser Glu Gln Thr Thr Glu Phe Gly Ile His Lys Pro His 
    370                 375                 380                 


Leu Gly Lys Ser Ser Ser Leu Asp Lys Gln Leu Pro Gly Pro Ser Gly 
385                 390                 395                 400 


Gly Glu Glu Glu Lys Pro Met Gly Asn Gly Ser Pro Ser Pro Pro Pro 
                405                 410                 415     


Gly Thr Ser Leu Asp Asn Pro Val Pro Ser Pro Ser Pro Ser Glu Ile 
            420                 425                 430         


Phe Pro Val Thr His Ser Phe Pro Ser Ser Ala His Ser Asp Thr His 
        435                 440                 445             


His Thr Ser Thr Ala Glu Ser Gln Lys Lys Ala Thr Ala Glu Gly Ser 
    450                 455                 460                 


Ala Gly Arg Val Glu Asn Phe Gly Lys Arg Lys Pro Leu Leu Gln Ala 
465                 470                 475                 480 


Trp Val Ser Pro Ser Glu Thr His Pro Val Ser Ala Gln Pro Gly Ala 
                485                 490                 495     


Gly Thr Gly Ser Ala Lys His Arg Leu His Pro Val Lys Pro Met Asn 
            500                 505                 510         


Ala Met Ala Thr Lys Val Ala Asn Cys Ser Leu Gly Thr Ala Thr Ile 
        515                 520                 525             


Ile Ser Glu Asn Leu Asn Asn Glu Val Met Met Lys Lys Tyr Ser Pro 
    530                 535                 540                 


Ser Asp Pro Ala Phe Ala Tyr Ala Gln Leu Thr His Asp Glu Leu Ile 
545                 550                 555                 560 


Gln Leu Val Leu Lys Gln Lys Glu Thr Ile Ser Lys Lys Glu Phe Gln 
                565                 570                 575     


Val Arg Glu Leu Glu Asp Tyr Ile Asp Asn Leu Leu Val Arg Val Met 
            580                 585                 590         


Glu Glu Thr Pro Asn Ile Leu Arg Ile Pro Thr Gln Val Gly Lys Lys 
        595                 600                 605             


Ala Gly Lys Met 
    610         


<210>  164
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Arg Asn Asn Met Thr Ala Ser Met Phe Asp Leu Ser Met Lys Asp 
1               5                   10                  15      


Lys Ser Arg Asn Pro Phe Gly Lys Leu Lys Asp Lys Ile Lys Gly Lys 
            20                  25                  30          


Asn Lys Asp Ser Gly Ser Asp Thr Ala Ser Ala Ile Ile Pro Ser Thr 
        35                  40                  45              


Thr Pro Ser Val Asp Ser Asp Asp Glu Ser Val Val Lys Asp Lys Lys 
    50                  55                  60                  


Lys Lys Ser Lys Ile Lys Thr Leu Leu Ser Lys Ser Asn Leu Gln Lys 
65                  70                  75                  80  


Thr Pro Leu Ser Gln Ser Met Ser Val Leu Pro Thr Ser Lys Pro Glu 
                85                  90                  95      


Lys Val Leu Leu Arg Pro Gly Asp Phe Gln Ser Gln Trp Asp Glu Asp 
            100                 105                 110         


Asp Asn Glu Asp Glu Ser Ser Ser Ala Ser Asp Val Met Ser His Lys 
        115                 120                 125             


Arg Thr Ala Ser Thr Asp Leu Lys Gln Leu Asn Gln Val Asn Phe Thr 
    130                 135                 140                 


Leu Pro Lys Lys Glu Gly Leu Ser Phe Leu Gly Gly Leu Arg Ser Lys 
145                 150                 155                 160 


Asn Asp Val Leu Ser Arg Ser Asn Val Cys Ile Asn Gly Asn His Val 
                165                 170                 175     


Tyr Leu Glu Gln Pro Glu Ala Lys Gly Glu Ile Lys Asp Ser Ser Pro 
            180                 185                 190         


Ser Ser Ser Pro Ser Pro Lys Gly Phe Arg Lys Lys His Leu Phe Ser 
        195                 200                 205             


Ser Thr Glu Asn Leu Ala Ala Gly Ser Trp Lys Glu Pro Ala Glu Gly 
    210                 215                 220                 


Gly Gly Leu Ser Ser Asp Arg Gln Leu Ser Glu Ser Ser Thr Lys Asp 
225                 230                 235                 240 


Ser Leu Lys Ser Met Thr Leu Pro Ser Tyr Arg Pro Ala Pro Leu Val 
                245                 250                 255     


Ser Gly Asp Leu Arg Glu Asn Met Ala Pro Ala Asn Ser Glu Ala Thr 
            260                 265                 270         


Lys Glu Ala Lys Glu Ser Lys Lys Pro Glu Ser Arg Arg Ser Ser Leu 
        275                 280                 285             


Leu Ser Leu Met Thr Gly Lys Lys Asp Val Ala Lys Gly Ser Glu Gly 
    290                 295                 300                 


Glu Asn Pro Leu Thr Val Pro Gly Arg Glu Lys Glu Gly Met Leu Met 
305                 310                 315                 320 


Gly Val Lys Pro Gly Glu Asp Ala Ser Gly Pro Ala Glu Asp Leu Val 
                325                 330                 335     


Arg Arg Ser Glu Lys Asp Thr Ala Ala Val Val Ser Arg Gln Gly Ser 
            340                 345                 350         


Ser Leu Asn Leu Phe Glu Asp Val Gln Ile Thr Glu Pro Glu Ala Glu 
        355                 360                 365             


Pro Glu Ser Lys Ser Glu Pro Arg Pro Pro Ile Ser Ser Pro Arg Ala 
    370                 375                 380                 


Pro Gln Thr Arg Ala Val Lys Pro Arg Leu His Pro Val Lys Pro Met 
385                 390                 395                 400 


Asn Ala Met Ala Thr Lys Val Ala Asn Cys Ser Leu Gly Thr Ala Thr 
                405                 410                 415     


Ile Ile Ser Glu Asn Leu Asn Asn Glu Val Met Met Lys Val Cys Pro 
            420                 425                 430         


Leu Arg Ser Trp Cys Val Arg 
        435                 


<210>  165
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Ser Leu Met Val Ser Ala Gly Arg Gly Leu Gly Ala Val Trp Ser 
1               5                   10                  15      


Pro Thr His Val Gln Val Thr Val Leu Gln Ala Arg Gly Leu Arg Ala 
            20                  25                  30          


Lys Gly Pro Gly Gly Thr Ser Asp Ala Tyr Ala Val Ile Gln Val Gly 
        35                  40                  45              


Lys Glu Lys Tyr Ala Thr Ser Val Ser Glu Arg Ser Leu Gly Ala Pro 
    50                  55                  60                  


Val Trp Arg Glu Glu Ala Thr Phe Glu Leu Pro Ser Leu Leu Ser Ser 
65                  70                  75                  80  


Gly Pro Ala Ala Ala Ala Thr Leu Gln Leu Thr Val Leu His Arg Ala 
                85                  90                  95      


Leu Leu Gly Leu Asp Lys Phe Leu Gly Arg Ala Glu Val Asp Leu Arg 
            100                 105                 110         


Asp Leu His Ser Ser Leu Gly Lys Ser Phe Phe Lys Thr Leu Lys Lys 
        115                 120                 125             


Arg Ala Trp Ala Ile Phe Leu Arg Leu Cys Leu Lys Lys Asn 
    130                 135                 140         


<210>  166
<211>  1020
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr 
1               5                   10                  15      


Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe 
            20                  25                  30          


Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala 
        35                  40                  45              


Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp 
    50                  55                  60                  


Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys 
65                  70                  75                  80  


Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg 
                85                  90                  95      


Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly 
            100                 105                 110         


Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn 
        115                 120                 125             


Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln 
    130                 135                 140                 


Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn 
                165                 170                 175     


Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val 
            180                 185                 190         


Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp 
        195                 200                 205             


Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu 
    210                 215                 220                 


Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu 
225                 230                 235                 240 


Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val 
                245                 250                 255     


Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly 
            260                 265                 270         


Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val 
        275                 280                 285             


Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu 
    290                 295                 300                 


Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly 
305                 310                 315                 320 


Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn 
                325                 330                 335     


His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys 
            340                 345                 350         


Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His 
        355                 360                 365             


Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys 
    370                 375                 380                 


Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn 
385                 390                 395                 400 


Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu 
                405                 410                 415     


Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu 
            420                 425                 430         


Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro 
        435                 440                 445             


Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp 
    450                 455                 460                 


Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met Thr Lys 
465                 470                 475                 480 


Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly Glu Thr 
                485                 490                 495     


Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser Asn Glu 
            500                 505                 510         


Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln Gln Thr 
        515                 520                 525             


Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp Asp Ser 
    530                 535                 540                 


Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala Cys Lys 
545                 550                 555                 560 


Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr Thr Ile 
                565                 570                 575     


Glu Ala Phe Ser Asp Glu Glu Val Gly Asn Asp Thr Gly Gln Val Gly 
            580                 585                 590         


Pro Gln Ala Asp Thr Asp Gly Glu Gly Leu Gln Lys Glu Val Tyr Arg 
        595                 600                 605             


His Glu Asn Asn Asn Gly Val Asp Gln Leu Asp Ala Lys Glu Ile Glu 
    610                 615                 620                 


Lys Glu Ser Asp Gly Gly His Ser Gln Lys Glu Ser Glu Ala Glu Glu 
625                 630                 635                 640 


Ile Asp Ser Glu Lys Glu Thr Lys Leu Ala Glu Ile Ala Gly Met Lys 
                645                 650                 655     


Asp Leu Arg Glu Arg Glu Lys Ser Thr Lys Lys Met Ser Pro Phe Phe 
            660                 665                 670         


Gly Asn Leu Pro Asp Arg Gly Met Asn Thr Glu Ser Glu Glu Asn Lys 
        675                 680                 685             


Asp Phe Val Lys Lys Arg Glu Ser Cys Lys Gln Asp Val Ile Phe Asp 
    690                 695                 700                 


Ser Glu Arg Glu Ser Val Glu Lys Pro Asp Ser Tyr Met Glu Gly Ala 
705                 710                 715                 720 


Ser Glu Ser Gln Gln Gly Ile Ala Asp Gly Phe Gln Gln Pro Glu Ala 
                725                 730                 735     


Ile Glu Phe Ser Ser Gly Glu Lys Glu Asp Asp Glu Val Glu Thr Asp 
            740                 745                 750         


Gln Asn Ile Arg Tyr Gly Arg Lys Leu Ile Glu Gln Gly Asn Glu Lys 
        755                 760                 765             


Glu Thr Lys Pro Ile Ile Ser Lys Ser Met Ala Lys Tyr Asp Phe Lys 
    770                 775                 780                 


Cys Asp Arg Leu Ser Glu Ile Pro Glu Glu Lys Glu Gly Ala Glu Asp 
785                 790                 795                 800 


Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val Glu Ala Asn Glu Glu 
                805                 810                 815     


Asn Val Lys Val His Gly Gly Arg Lys Glu Lys Thr Glu Ile Leu Ser 
            820                 825                 830         


Asp Asp Leu Thr Asp Lys Ala Glu Asp His Glu Phe Ser Lys Thr Glu 
        835                 840                 845             


Glu Leu Lys Leu Glu Asp Val Asp Glu Glu Ile Asn Ala Glu Asn Val 
    850                 855                 860                 


Glu Ser Lys Lys Lys Thr Val Gly Asp Asp Glu Ser Val Pro Thr Gly 
865                 870                 875                 880 


Tyr His Ser Lys Thr Glu Gly Ala Glu Arg Thr Asn Asp Asp Ser Ser 
                885                 890                 895     


Ala Glu Thr Ile Glu Lys Lys Glu Lys Ala Asn Leu Glu Glu Arg Ala 
            900                 905                 910         


Ile Cys Glu Tyr Asn Glu Asn Pro Lys Gly Tyr Met Leu Asp Asp Ala 
        915                 920                 925             


Asp Ser Ser Ser Leu Glu Ile Leu Glu Asn Ser Glu Thr Thr Pro Ser 
    930                 935                 940                 


Lys Asp Met Lys Lys Thr Lys Lys Ile Phe Leu Phe Lys Arg Val Pro 
945                 950                 955                 960 


Ser Ile Asn Gln Lys Ile Val Lys Asn Asn Asn Glu Pro Leu Pro Glu 
                965                 970                 975     


Ile Lys Ser Ile Gly Asp Gln Ile Ile Leu Lys Ser Asp Asn Lys Asp 
            980                 985                 990         


Ala Asp Gln Asn His Met Ser Gln  Asn His Gln Asn Ile  Pro Pro Thr 
        995                 1000                 1005             


Asn Thr  Glu Arg Arg Ser Lys  Ser Cys Thr Ile Leu  
    1010                 1015                 1020 


<210>  167
<211>  815
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr 
1               5                   10                  15      


Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe 
            20                  25                  30          


Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala 
        35                  40                  45              


Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp 
    50                  55                  60                  


Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys 
65                  70                  75                  80  


Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg 
                85                  90                  95      


Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly 
            100                 105                 110         


Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn 
        115                 120                 125             


Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln 
    130                 135                 140                 


Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn 
                165                 170                 175     


Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val 
            180                 185                 190         


Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp 
        195                 200                 205             


Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu 
    210                 215                 220                 


Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu 
225                 230                 235                 240 


Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val 
                245                 250                 255     


Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly 
            260                 265                 270         


Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val 
        275                 280                 285             


Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu 
    290                 295                 300                 


Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly 
305                 310                 315                 320 


Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn 
                325                 330                 335     


His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys 
            340                 345                 350         


Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His 
        355                 360                 365             


Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys 
    370                 375                 380                 


Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn 
385                 390                 395                 400 


Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu 
                405                 410                 415     


Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu 
            420                 425                 430         


Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro 
        435                 440                 445             


Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp 
    450                 455                 460                 


Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met Thr Lys 
465                 470                 475                 480 


Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly Glu Thr 
                485                 490                 495     


Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser Asn Glu 
            500                 505                 510         


Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln Gln Thr 
        515                 520                 525             


Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp Asp Ser 
    530                 535                 540                 


Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala Cys Lys 
545                 550                 555                 560 


Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr Thr Ile 
                565                 570                 575     


Glu Ala Phe Ser Asp Glu Glu Val Glu Ile Pro Glu Glu Lys Glu Gly 
            580                 585                 590         


Ala Glu Asp Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val Glu Ala 
        595                 600                 605             


Asn Glu Glu Asn Val Lys Val His Gly Gly Arg Lys Glu Lys Thr Glu 
    610                 615                 620                 


Ile Leu Ser Asp Asp Leu Thr Asp Lys Ala Glu Asp His Glu Phe Ser 
625                 630                 635                 640 


Lys Thr Glu Glu Leu Lys Leu Glu Asp Val Asp Glu Glu Ile Asn Ala 
                645                 650                 655     


Glu Asn Val Glu Ser Lys Lys Lys Thr Val Gly Asp Asp Glu Ser Val 
            660                 665                 670         


Pro Thr Gly Tyr His Ser Lys Thr Glu Gly Ala Glu Arg Thr Asn Asp 
        675                 680                 685             


Asp Ser Ser Ala Glu Thr Ile Glu Lys Lys Glu Lys Ala Asn Leu Glu 
    690                 695                 700                 


Glu Arg Ala Ile Cys Glu Tyr Asn Glu Asn Pro Lys Gly Tyr Met Leu 
705                 710                 715                 720 


Asp Asp Ala Asp Ser Ser Ser Leu Glu Ile Leu Glu Asn Ser Glu Thr 
                725                 730                 735     


Thr Pro Ser Lys Asp Met Lys Lys Thr Lys Lys Ile Phe Leu Phe Lys 
            740                 745                 750         


Arg Val Pro Ser Ile Asn Gln Lys Ile Val Lys Asn Asn Asn Glu Pro 
        755                 760                 765             


Leu Pro Glu Ile Lys Ser Ile Gly Asp Gln Ile Ile Leu Lys Ser Asp 
    770                 775                 780                 


Asn Lys Asp Ala Asp Gln Asn His Met Ser Gln Asn His Gln Asn Ile 
785                 790                 795                 800 


Pro Pro Thr Asn Thr Glu Arg Arg Ser Lys Ser Cys Thr Ile Leu 
                805                 810                 815 


<210>  168
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr 
1               5                   10                  15      


Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe 
            20                  25                  30          


Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala 
        35                  40                  45              


Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp 
    50                  55                  60                  


Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys 
65                  70                  75                  80  


Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg 
                85                  90                  95      


Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly 
            100                 105                 110         


Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn 
        115                 120                 125             


Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln 
    130                 135                 140                 


Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn 
                165                 170                 175     


Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val 
            180                 185                 190         


Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp 
        195                 200                 205             


Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu 
    210                 215                 220                 


Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu 
225                 230                 235                 240 


Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val 
                245                 250                 255     


Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly 
            260                 265                 270         


Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val 
        275                 280                 285             


Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu 
    290                 295                 300                 


Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly 
305                 310                 315                 320 


Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn 
                325                 330                 335     


His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys 
            340                 345                 350         


Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His 
        355                 360                 365             


Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys 
    370                 375                 380                 


Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn 
385                 390                 395                 400 


Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu 
                405                 410                 415     


Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu 
            420                 425                 430         


Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro 
        435                 440                 445             


Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp 
    450                 455                 460                 


Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met Thr Lys 
465                 470                 475                 480 


Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly Glu Thr 
                485                 490                 495     


Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser Asn Glu 
            500                 505                 510         


Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln Gln Thr 
        515                 520                 525             


Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp Asp Ser 
    530                 535                 540                 


Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala Cys Lys 
545                 550                 555                 560 


Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr Thr Ile 
                565                 570                 575     


Glu Ala Phe Ser Asp Glu Glu Val Glu Ile Pro Glu Glu Lys Glu Gly 
            580                 585                 590         


Ala Glu Asp Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val Glu Ala 
        595                 600                 605             


Asn Glu Glu Asn Val Lys Val His Gly Gly Arg Lys Glu Lys Thr Glu 
    610                 615                 620                 


Ile Leu Ser Asp Asp Leu Thr Asp Lys Ala Glu Tyr Ser Ala Ser His 
625                 630                 635                 640 


Ser Gln Ile Val Ser Val 
                645     


<210>  169
<211>  753
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr 
1               5                   10                  15      


Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe 
            20                  25                  30          


Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala 
        35                  40                  45              


Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp 
    50                  55                  60                  


Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys 
65                  70                  75                  80  


Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg 
                85                  90                  95      


Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly 
            100                 105                 110         


Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn 
        115                 120                 125             


Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln 
    130                 135                 140                 


Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn 
                165                 170                 175     


Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val 
            180                 185                 190         


Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp 
        195                 200                 205             


Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu 
    210                 215                 220                 


Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu 
225                 230                 235                 240 


Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val 
                245                 250                 255     


Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly 
            260                 265                 270         


Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val 
        275                 280                 285             


Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu 
    290                 295                 300                 


Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly 
305                 310                 315                 320 


Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn 
                325                 330                 335     


His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys 
            340                 345                 350         


Leu Glu Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro 
        355                 360                 365             


Ile Glu Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val 
    370                 375                 380                 


Phe Pro Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu 
385                 390                 395                 400 


Gln Asp Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met 
                405                 410                 415     


Thr Lys Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly 
            420                 425                 430         


Glu Thr Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser 
        435                 440                 445             


Asn Glu Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln 
    450                 455                 460                 


Gln Thr Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp 
465                 470                 475                 480 


Asp Ser Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala 
                485                 490                 495     


Cys Lys Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr 
            500                 505                 510         


Thr Ile Glu Ala Phe Ser Asp Glu Glu Val Glu Ile Pro Glu Glu Lys 
        515                 520                 525             


Glu Gly Ala Glu Asp Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val 
    530                 535                 540                 


Glu Ala Asn Glu Glu Asn Val Lys Val His Gly Gly Arg Lys Glu Lys 
545                 550                 555                 560 


Thr Glu Ile Leu Ser Asp Asp Leu Thr Asp Lys Ala Glu Asp His Glu 
                565                 570                 575     


Phe Ser Lys Thr Glu Glu Leu Lys Leu Glu Asp Val Asp Glu Glu Ile 
            580                 585                 590         


Asn Ala Glu Asn Val Glu Ser Lys Lys Lys Thr Val Gly Asp Asp Glu 
        595                 600                 605             


Ser Val Pro Thr Gly Tyr His Ser Lys Thr Glu Gly Ala Glu Arg Thr 
    610                 615                 620                 


Asn Asp Asp Ser Ser Ala Glu Thr Ile Glu Lys Lys Glu Lys Ala Asn 
625                 630                 635                 640 


Leu Glu Glu Arg Ala Ile Cys Glu Tyr Asn Glu Asn Pro Lys Gly Tyr 
                645                 650                 655     


Met Leu Asp Asp Ala Asp Ser Ser Ser Leu Glu Ile Leu Glu Asn Ser 
            660                 665                 670         


Glu Thr Thr Pro Ser Lys Asp Met Lys Lys Thr Lys Lys Ile Phe Leu 
        675                 680                 685             


Phe Lys Arg Val Pro Ser Ile Asn Gln Lys Ile Val Lys Asn Asn Asn 
    690                 695                 700                 


Glu Pro Leu Pro Glu Ile Lys Ser Ile Gly Asp Gln Ile Ile Leu Lys 
705                 710                 715                 720 


Ser Asp Asn Lys Asp Ala Asp Gln Asn His Met Ser Gln Asn His Gln 
                725                 730                 735     


Asn Ile Pro Pro Thr Asn Thr Glu Arg Arg Ser Lys Ser Cys Thr Ile 
            740                 745                 750         


Leu 
    


<210>  170
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr 
1               5                   10                  15      


Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe 
            20                  25                  30          


Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala 
        35                  40                  45              


Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp 
    50                  55                  60                  


Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys 
65                  70                  75                  80  


Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg 
                85                  90                  95      


Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly 
            100                 105                 110         


Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn 
        115                 120                 125             


Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln 
    130                 135                 140                 


Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn 
                165                 170                 175     


Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val 
            180                 185                 190         


Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp 
        195                 200                 205             


Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu 
    210                 215                 220                 


Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu 
225                 230                 235                 240 


Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val 
                245                 250                 255     


Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly 
            260                 265                 270         


Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val 
        275                 280                 285             


Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu 
    290                 295                 300                 


Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly 
305                 310                 315                 320 


Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn 
                325                 330                 335     


His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys 
            340                 345                 350         


Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His 
        355                 360                 365             


Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys 
    370                 375                 380                 


Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn 
385                 390                 395                 400 


Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu 
                405                 410                 415     


Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu 
            420                 425                 430         


Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro 
        435                 440                 445             


Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp 
    450                 455                 460                 


Leu Met Gln Pro Glu Glu Pro Asp Thr His His Glu Pro Glu Phe Gln 
465                 470                 475                 480 


<210>  171
<211>  1152
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr 
1               5                   10                  15      


Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe 
            20                  25                  30          


Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala 
        35                  40                  45              


Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp 
    50                  55                  60                  


Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys 
65                  70                  75                  80  


Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg 
                85                  90                  95      


Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly 
            100                 105                 110         


Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn 
        115                 120                 125             


Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln 
    130                 135                 140                 


Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn 
                165                 170                 175     


Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val 
            180                 185                 190         


Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp 
        195                 200                 205             


Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu 
    210                 215                 220                 


Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu 
225                 230                 235                 240 


Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val 
                245                 250                 255     


Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly 
            260                 265                 270         


Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val 
        275                 280                 285             


Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu 
    290                 295                 300                 


Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly 
305                 310                 315                 320 


Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn 
                325                 330                 335     


His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys 
            340                 345                 350         


Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His 
        355                 360                 365             


Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys 
    370                 375                 380                 


Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn 
385                 390                 395                 400 


Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu 
                405                 410                 415     


Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu 
            420                 425                 430         


Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro 
        435                 440                 445             


Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp 
    450                 455                 460                 


Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met Thr Lys 
465                 470                 475                 480 


Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly Glu Thr 
                485                 490                 495     


Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser Asn Glu 
            500                 505                 510         


Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln Gln Thr 
        515                 520                 525             


Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp Asp Ser 
    530                 535                 540                 


Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala Cys Lys 
545                 550                 555                 560 


Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr Thr Ile 
                565                 570                 575     


Glu Ala Phe Ser Asp Glu Glu Val Glu Ile Pro Glu Glu Lys Glu Gly 
            580                 585                 590         


Ala Glu Asp Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val Glu Ala 
        595                 600                 605             


Asn Glu Glu Asn Val Lys Val His Gly Gly Arg Lys Glu Lys Thr Glu 
    610                 615                 620                 


Ile Leu Ser Asp Asp Leu Thr Asp Lys Ala Glu Val Ser Glu Gly Lys 
625                 630                 635                 640 


Ala Lys Ser Val Gly Glu Ala Glu Asp Gly Pro Glu Gly Arg Gly Asp 
                645                 650                 655     


Gly Thr Cys Glu Glu Gly Ser Ser Gly Ala Glu His Trp Gln Asp Glu 
            660                 665                 670         


Glu Arg Glu Lys Gly Glu Lys Asp Lys Gly Arg Gly Glu Met Glu Arg 
        675                 680                 685             


Pro Gly Glu Gly Glu Lys Glu Leu Ala Glu Lys Glu Glu Trp Lys Lys 
    690                 695                 700                 


Arg Asp Gly Glu Glu Gln Glu Gln Lys Glu Arg Glu Gln Gly His Gln 
705                 710                 715                 720 


Lys Glu Arg Asn Gln Glu Met Glu Glu Gly Gly Glu Glu Glu His Gly 
                725                 730                 735     


Glu Gly Glu Glu Glu Glu Gly Asp Arg Glu Glu Glu Glu Glu Lys Glu 
            740                 745                 750         


Gly Glu Gly Lys Glu Glu Gly Glu Gly Glu Glu Val Glu Gly Glu Arg 
        755                 760                 765             


Glu Lys Glu Glu Gly Glu Arg Lys Lys Glu Glu Arg Ala Gly Lys Glu 
    770                 775                 780                 


Glu Lys Gly Glu Glu Glu Gly Asp Gln Gly Glu Gly Glu Glu Glu Glu 
785                 790                 795                 800 


Thr Glu Gly Arg Gly Glu Glu Lys Glu Glu Gly Gly Glu Val Glu Gly 
                805                 810                 815     


Gly Glu Val Glu Glu Gly Lys Gly Glu Arg Glu Glu Glu Glu Glu Glu 
            820                 825                 830         


Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu 
        835                 840                 845             


Gly Glu Glu Glu Glu Gly Glu Gly Lys Gly Glu Glu Glu Gly Glu Glu 
    850                 855                 860                 


Gly Glu Gly Glu Glu Glu Gly Glu Glu Gly Glu Gly Glu Gly Glu Glu 
865                 870                 875                 880 


Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly Glu 
                885                 890                 895     


Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly 
            900                 905                 910         


Glu Glu Glu Glu Gly Glu Gly Lys Gly Glu Glu Glu Gly Glu Glu Gly 
        915                 920                 925             


Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Asp Gly 
    930                 935                 940                 


Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Trp Glu Gly Glu Glu Glu 
945                 950                 955                 960 


Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu 
                965                 970                 975     


Gly Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu 
            980                 985                 990         


Glu Glu Gly Glu Glu Glu Gly Glu  Glu Glu Gly Glu Gly  Glu Glu Glu 
        995                 1000                 1005             


Gly Glu  Gly Glu Gly Glu Glu  Glu Glu Glu Gly Glu  Val Glu Gly 
    1010                 1015                 1020             


Glu Val  Glu Gly Glu Glu Gly  Glu Gly Glu Gly Glu  Glu Glu Glu 
    1025                 1030                 1035             


Gly Glu  Glu Glu Gly Glu Glu  Arg Glu Lys Glu Gly  Glu Gly Glu 
    1040                 1045                 1050             


Glu Asn  Arg Arg Asn Arg Glu  Glu Glu Glu Glu Glu  Glu Gly Lys 
    1055                 1060                 1065             


Tyr Gln  Glu Thr Gly Glu Glu  Glu Asn Glu Arg Gln  Asp Gly Glu 
    1070                 1075                 1080             


Glu Tyr  Lys Lys Val Ser Lys  Ile Lys Gly Ser Val  Lys Tyr Gly 
    1085                 1090                 1095             


Lys His  Lys Thr Tyr Gln Lys  Lys Ser Val Thr Asn  Thr Gln Gly 
    1100                 1105                 1110             


Asn Gly  Lys Glu Gln Arg Ser  Lys Met Pro Val Gln  Ser Lys Arg 
    1115                 1120                 1125             


Leu Leu  Lys Asn Gly Pro Ser  Gly Ser Lys Lys Phe  Trp Asn Asn 
    1130                 1135                 1140             


Val Leu  Pro His Tyr Leu Glu  Leu Lys 
    1145                 1150         


<210>  172
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Ile Ser Val Lys Arg Asn Thr Trp Arg Ala Leu Ser Leu Val Ile 
1               5                   10                  15      


Gly Asp Cys Arg Lys Lys Gly Asn Phe Glu Tyr Cys Gln Asp Arg Thr 
            20                  25                  30          


Glu Lys His Ser Thr Met Pro Asp Ser Pro Val Asp Val Lys Thr Gln 
        35                  40                  45              


Ser Arg Leu Thr Pro Pro Thr Met Pro Pro Pro Pro Thr Thr Gln Gly 
    50                  55                  60                  


Ala Pro Arg Thr Ser Ser Phe Thr Pro Thr Thr Leu Thr Asn Gly Thr 
65                  70                  75                  80  


Ser His Ser Pro Thr Ala Leu Asn Gly Ala Pro Ser Pro Pro Asn Gly 
                85                  90                  95      


Phe Ser Asn Gly Pro Ser Ser Ser Ser Ser Ser Ser Leu Ala Asn Gln 
            100                 105                 110         


Gln Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu Ser Lys Leu Lys Arg 
        115                 120                 125             


Phe Leu Thr Thr Leu Gln Gln Phe Gly Asn Asp Ile Ser Pro Glu Ile 
    130                 135                 140                 


Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu Val Asn Ser Thr Leu 
145                 150                 155                 160 


Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu Ala Thr Asn Phe Pro 
                165                 170                 175     


Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn Leu Pro Leu Leu 
            180                 185                 190         


Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala Lys Gln Asn Pro Ala 
        195                 200                 205             


Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu Asp Ala Ser Thr Thr 
    210                 215                 220                 


Ser Pro Val Asp Ser Ser Glu Leu Leu Leu Asp Val Asn Glu Asn Gly 
225                 230                 235                 240 


Lys Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn Gly Phe Asp Arg Glu 
                245                 250                 255     


Pro Leu His Ser Glu His Pro Ser Lys Arg Pro Cys Thr Ile Ser Pro 
            260                 265                 270         


Gly Gln Arg Tyr Ser Pro Asn Asn Gly Leu Ser Tyr Gln Pro Asn Gly 
        275                 280                 285             


Leu Pro His Pro Thr Pro Pro Pro Pro Gln His Tyr Arg Leu Asp Asp 
    290                 295                 300                 


Met Ala Ile Ala His His Tyr Arg Asp Ser Tyr Arg His Pro Ser His 
305                 310                 315                 320 


Arg Asp Leu Arg Asp Arg Asn Arg Pro Met Gly Leu His Gly Thr Arg 
                325                 330                 335     


Gln Glu Glu Met Ile Asp His Arg Leu Thr Asp Arg Glu Trp Ala Glu 
            340                 345                 350         


Glu Trp Lys His Leu Asp His Leu Leu Asn Cys Ile Met Asp Met Val 
        355                 360                 365             


Glu Lys Thr Arg Arg Ser Leu Thr Val Leu Arg Arg Cys Gln Glu Ala 
    370                 375                 380                 


Asp Arg Glu Glu Leu Asn Tyr Trp Ile Arg Arg Tyr Ser Asp Ala Glu 
385                 390                 395                 400 


Asp Leu Lys Lys Gly Gly Gly Ser Ser Ser Ser His Ser Arg Gln Gln 
                405                 410                 415     


Ser Pro Val Asn Pro Asp Pro Val Ala Leu Asp Ala His Arg Glu Phe 
            420                 425                 430         


Leu His Arg Pro Ala Ser Gly Tyr Val Pro Glu Glu Ile Trp Lys Lys 
        435                 440                 445             


Ala Glu Glu Ala Val Asn Glu Val Lys Arg Gln Ala Met Thr Glu Leu 
    450                 455                 460                 


Gln Lys Ala Val Ser Glu Ala Glu Arg Lys Ala His Asp Met Ile Thr 
465                 470                 475                 480 


Thr Glu Arg Ala Lys Met Glu Arg Thr Val Ala Glu Ala Lys Arg Gln 
                485                 490                 495     


Ala Ala Glu Asp Ala Leu Ala Val Ile Asn Gln Gln Glu Asp Ser Ser 
            500                 505                 510         


Glu Ser Cys Trp Asn Cys Gly Arg Lys Ala Ser Glu Thr Cys Ser Gly 
        515                 520                 525             


Cys Asn Thr Ala Arg Tyr Cys Gly Ser Phe Cys Gln His Lys Asp Trp 
    530                 535                 540                 


Glu Lys His His His Ile Cys Gly Gln Thr Leu Gln Ala Gln Gln Gln 
545                 550                 555                 560 


Gly Asp Thr Pro Ala Val Ser Ser Ser Val Thr Pro Asn Ser Gly Ala 
                565                 570                 575     


Gly Ser Pro Met Asp Thr Pro Pro Ala Ala Thr Pro Arg Ser Thr Thr 
            580                 585                 590         


Pro Gly Thr Pro Ser Thr Ile Glu Thr Thr Pro Arg 
        595                 600                 


<210>  173
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Pro Asp Arg Thr Glu Lys His Ser Thr Met Pro Asp Ser Pro Val 
1               5                   10                  15      


Asp Val Lys Thr Gln Ser Arg Leu Thr Pro Pro Thr Met Pro Pro Pro 
            20                  25                  30          


Pro Thr Thr Gln Gly Ala Pro Arg Thr Ser Ser Phe Thr Pro Thr Thr 
        35                  40                  45              


Leu Thr Asn Gly Thr Ser His Ser Pro Thr Ala Leu Asn Gly Ala Pro 
    50                  55                  60                  


Ser Pro Pro Asn Gly Phe Ser Asn Gly Pro Ser Ser Ser Ser Ser Ser 
65                  70                  75                  80  


Ser Leu Ala Asn Gln Gln Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu 
                85                  90                  95      


Ser Lys Leu Lys Arg Phe Leu Thr Thr Leu Gln Gln Phe Gly Asn Asp 
            100                 105                 110         


Ile Ser Pro Glu Ile Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu 
        115                 120                 125             


Val Asn Ser Thr Leu Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu 
    130                 135                 140                 


Ala Thr Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala 
145                 150                 155                 160 


Asn Leu Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala 
                165                 170                 175     


Lys Gln Asn Pro Ala Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu 
            180                 185                 190         


Asp Ala Ser Thr Thr Ser Pro Val Asp Ser Ser Glu Leu Leu Leu Asp 
        195                 200                 205             


Val Asn Glu Asn Gly Lys Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn 
    210                 215                 220                 


Gly Phe Asp Arg Glu Pro Leu His Ser Glu His Pro Ser Lys Arg Pro 
225                 230                 235                 240 


Cys Thr Ile Ser Pro Gly Gln Arg Tyr Ser Pro Asn Asn Gly Leu Ser 
                245                 250                 255     


Tyr Gln Pro Asn Gly Leu Pro His Pro Thr Pro Pro Pro Pro Gln His 
            260                 265                 270         


Tyr Arg Leu Asp Asp Met Ala Ile Ala His His Tyr Arg Asp Ser Tyr 
        275                 280                 285             


Arg His Pro Ser His Arg Asp Leu Arg Asp Arg Asn Arg Pro Met Gly 
    290                 295                 300                 


Leu His Gly Thr Arg Gln Glu Glu Met Ile Asp His Arg Leu Thr Asp 
305                 310                 315                 320 


Arg Glu Trp Ala Glu Glu Trp Lys His Leu Asp His Leu Leu Asn Cys 
                325                 330                 335     


Ile Met Asp Met Val Glu Lys Thr Arg Arg Ser Leu Thr Val Leu Arg 
            340                 345                 350         


Arg Cys Gln Glu Ala Asp Arg Glu Glu Leu Asn Tyr Trp Ile Arg Arg 
        355                 360                 365             


Tyr Ser Asp Ala Glu Asp Leu Lys Lys Gly Gly Gly Ser Ser Ser Ser 
    370                 375                 380                 


His Ser Arg Gln Gln Ser Pro Val Asn Pro Asp Pro Val Ala Leu Asp 
385                 390                 395                 400 


Ala His Arg Glu Phe Leu His Arg Pro Ala Ser Gly Tyr Val Pro Glu 
                405                 410                 415     


Glu Ile Trp Lys Lys Ala Glu Glu Ala Val Asn Glu Val Lys Arg Gln 
            420                 425                 430         


Ala Met Thr Glu Leu Gln Lys Ala Val Ser Glu Ala Glu Arg Lys Ala 
        435                 440                 445             


His Asp Met Ile Thr Thr Glu Arg Ala Lys Met Glu Arg Thr Val Ala 
    450                 455                 460                 


Glu Ala Lys Arg Gln Ala Ala Glu Asp Ala Leu Ala Val Ile Asn Gln 
465                 470                 475                 480 


Gln Glu Asp Ser Ser Glu Ser Cys Trp Asn Cys Gly Arg Lys Ala Ser 
                485                 490                 495     


Glu Thr Cys Ser Gly Cys Asn Thr Ala Arg Tyr Cys Gly Ser Phe Cys 
            500                 505                 510         


Gln His Lys Asp Trp Glu Lys His His His Ile Cys Gly Gln Thr Leu 
        515                 520                 525             


Gln Ala Gln Gln Gln Gly Asp Thr Pro Ala Val Ser Ser Ser Val Thr 
    530                 535                 540                 


Pro Asn Ser Gly Ala Gly Ser Pro Met Asp Thr Pro Pro Ala Ala Thr 
545                 550                 555                 560 


Pro Arg Ser Thr Thr Pro Gly Thr Pro Ser Thr Ile Glu Thr Thr Pro 
                565                 570                 575     


Arg 
    


<210>  174
<211>  615
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Cys His Pro Asp Lys Ala Phe Thr Ser Asp Lys Leu Gln Cys Val 
1               5                   10                  15      


Phe Asn Glu Tyr Lys Ala Ala Val Trp Val Pro Pro Arg Pro Arg Pro 
            20                  25                  30          


Leu Ser Arg Ala Pro Leu Pro Glu Asp Arg Thr Glu Lys His Ser Thr 
        35                  40                  45              


Met Pro Asp Ser Pro Val Asp Val Lys Thr Gln Ser Arg Leu Thr Pro 
    50                  55                  60                  


Pro Thr Met Pro Pro Pro Pro Thr Thr Gln Gly Ala Pro Arg Thr Ser 
65                  70                  75                  80  


Ser Phe Thr Pro Thr Thr Leu Thr Asn Gly Thr Ser His Ser Pro Thr 
                85                  90                  95      


Ala Leu Asn Gly Ala Pro Ser Pro Pro Asn Gly Phe Ser Asn Gly Pro 
            100                 105                 110         


Ser Ser Ser Ser Ser Ser Ser Leu Ala Asn Gln Gln Leu Pro Pro Ala 
        115                 120                 125             


Cys Gly Ala Arg Gln Leu Ser Lys Leu Lys Arg Phe Leu Thr Thr Leu 
    130                 135                 140                 


Gln Gln Phe Gly Asn Asp Ile Ser Pro Glu Ile Gly Glu Arg Val Arg 
145                 150                 155                 160 


Thr Leu Val Leu Gly Leu Val Asn Ser Thr Leu Thr Ile Glu Glu Phe 
                165                 170                 175     


His Ser Lys Leu Gln Glu Ala Thr Asn Phe Pro Leu Arg Pro Phe Val 
            180                 185                 190         


Ile Pro Phe Leu Lys Ala Asn Leu Pro Leu Leu Gln Arg Glu Leu Leu 
        195                 200                 205             


His Cys Ala Arg Leu Ala Lys Gln Asn Pro Ala Gln Tyr Leu Ala Gln 
    210                 215                 220                 


His Glu Gln Leu Leu Leu Asp Ala Ser Thr Thr Ser Pro Val Asp Ser 
225                 230                 235                 240 


Ser Glu Leu Leu Leu Asp Val Asn Glu Asn Gly Lys Arg Arg Thr Pro 
                245                 250                 255     


Asp Arg Thr Lys Glu Asn Gly Phe Asp Arg Glu Pro Leu His Ser Glu 
            260                 265                 270         


His Pro Ser Lys Arg Pro Cys Thr Ile Ser Pro Gly Gln Arg Tyr Ser 
        275                 280                 285             


Pro Asn Asn Gly Leu Ser Tyr Gln Pro Asn Gly Leu Pro His Pro Thr 
    290                 295                 300                 


Pro Pro Pro Pro Gln His Tyr Arg Leu Asp Asp Met Ala Ile Ala His 
305                 310                 315                 320 


His Tyr Arg Asp Ser Tyr Arg His Pro Ser His Arg Asp Leu Arg Asp 
                325                 330                 335     


Arg Asn Arg Pro Met Gly Leu His Gly Thr Arg Gln Glu Glu Met Ile 
            340                 345                 350         


Asp His Arg Leu Thr Asp Arg Glu Trp Ala Glu Glu Trp Lys His Leu 
        355                 360                 365             


Asp His Leu Leu Asn Cys Ile Met Asp Met Val Glu Lys Thr Arg Arg 
    370                 375                 380                 


Ser Leu Thr Val Leu Arg Arg Cys Gln Glu Ala Asp Arg Glu Glu Leu 
385                 390                 395                 400 


Asn Tyr Trp Ile Arg Arg Tyr Ser Asp Ala Glu Asp Leu Lys Lys Gly 
                405                 410                 415     


Gly Gly Ser Ser Ser Ser His Ser Arg Gln Gln Ser Pro Val Asn Pro 
            420                 425                 430         


Asp Pro Val Ala Leu Asp Ala His Arg Glu Phe Leu His Arg Pro Ala 
        435                 440                 445             


Ser Gly Tyr Val Pro Glu Glu Ile Trp Lys Lys Ala Glu Glu Ala Val 
    450                 455                 460                 


Asn Glu Val Lys Arg Gln Ala Met Thr Glu Leu Gln Lys Ala Val Ser 
465                 470                 475                 480 


Glu Ala Glu Arg Lys Ala His Asp Met Ile Thr Thr Glu Arg Ala Lys 
                485                 490                 495     


Met Glu Arg Thr Val Ala Glu Ala Lys Arg Gln Ala Ala Glu Asp Ala 
            500                 505                 510         


Leu Ala Val Ile Asn Gln Gln Glu Asp Ser Ser Glu Ser Cys Trp Asn 
        515                 520                 525             


Cys Gly Arg Lys Ala Ser Glu Thr Cys Ser Gly Cys Asn Thr Ala Arg 
    530                 535                 540                 


Tyr Cys Gly Ser Phe Cys Gln His Lys Asp Trp Glu Lys His His His 
545                 550                 555                 560 


Ile Cys Gly Gln Thr Leu Gln Ala Gln Gln Gln Gly Asp Thr Pro Ala 
                565                 570                 575     


Val Ser Ser Ser Val Thr Pro Asn Ser Gly Ala Gly Ser Pro Met Asp 
            580                 585                 590         


Thr Pro Pro Ala Ala Thr Pro Arg Ser Thr Thr Pro Gly Thr Pro Ser 
        595                 600                 605             


Thr Ile Glu Thr Thr Pro Arg 
    610                 615 


<210>  175
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Pro Asp Ser Pro Val Asp Val Lys Thr Gln Ser Arg Leu Thr Pro 
1               5                   10                  15      


Pro Thr Met Pro Pro Pro Pro Thr Thr Gln Gly Ala Pro Arg Thr Ser 
            20                  25                  30          


Ser Phe Thr Pro Thr Thr Leu Thr Asn Gly Thr Ser His Ser Pro Thr 
        35                  40                  45              


Ala Leu Asn Gly Ala Pro Ser Pro Pro Asn Gly Phe Ser Asn Gly Pro 
    50                  55                  60                  


Ser Ser Ser Ser Ser Ser Ser Leu Ala Asn Gln Gln Leu Pro Pro Ala 
65                  70                  75                  80  


Cys Gly Ala Arg Gln Leu Ser Lys Leu Lys Arg Phe Leu Thr Thr Leu 
                85                  90                  95      


Gln Gln Phe Gly Asn Asp Ile Ser Pro Glu Ile Gly Glu Arg Val Arg 
            100                 105                 110         


Thr Leu Val Leu Gly Leu Val Asn Ser Thr Leu Thr Ile Glu Glu Phe 
        115                 120                 125             


His Ser Lys Leu Gln Glu Ala Thr Asn Phe Pro Leu Arg Pro Phe Val 
    130                 135                 140                 


Ile Pro Phe Leu Lys Ala Asn Leu Pro Leu Leu Gln Arg Glu Leu Leu 
145                 150                 155                 160 


His Cys Ala Arg Leu Ala Lys Gln Asn Pro Ala Gln Tyr Leu Ala Gln 
                165                 170                 175     


His Glu Gln Leu Leu Leu Asp Ala Ser Thr Thr Ser Pro Val Asp Ser 
            180                 185                 190         


Ser Glu Leu Leu Leu Asp Val Asn Glu Asn Gly Lys Arg Arg Thr Pro 
        195                 200                 205             


Asp Arg Thr Lys Glu Asn Gly Phe Asp Arg Glu Pro Leu His Ser Glu 
    210                 215                 220                 


His Pro Ser Lys Arg Pro Cys Thr Ile Ser Pro Gly Gln Arg Tyr Ser 
225                 230                 235                 240 


Pro Asn Asn Gly Leu Ser Tyr Gln Pro Asn Gly Leu Pro His Pro Thr 
                245                 250                 255     


Pro Pro Pro Pro Gln His Tyr Arg Leu Asp Asp Met Ala Ile Ala His 
            260                 265                 270         


His Tyr Arg Asp Ser Tyr Arg His Pro Ser His Arg Asp Leu Arg Asp 
        275                 280                 285             


Arg Asn Arg Pro Met Gly Leu His Gly Thr Arg Gln Glu Glu Met Ile 
    290                 295                 300                 


Asp His Arg Leu Thr Asp Arg Glu Trp Ala Glu Glu Trp Lys His Leu 
305                 310                 315                 320 


Asp His Leu Leu Asn Cys Ile Met Asp Met Val Glu Lys Thr Arg Arg 
                325                 330                 335     


Ser Leu Thr Val Leu Arg Arg Cys Gln Glu Ala Asp Arg Glu Glu Leu 
            340                 345                 350         


Asn Tyr Trp Ile Arg Arg Tyr Ser Asp Ala Glu Asp Leu Lys Lys Gly 
        355                 360                 365             


Gly Gly Ser Ser Ser Ser His Ser Arg Gln Gln Ser Pro Val Asn Pro 
    370                 375                 380                 


Asp Pro Val Ala Leu Asp Ala His Arg Glu Phe Leu His Arg Pro Ala 
385                 390                 395                 400 


Ser Gly Tyr Val Pro Glu Glu Ile Trp Lys Lys Ala Glu Glu Ala Val 
                405                 410                 415     


Asn Glu Val Lys Arg Gln Ala Met Thr Glu Leu Gln Lys Ala Val Ser 
            420                 425                 430         


Glu Ala Glu Arg Lys Ala His Asp Met Ile Thr Thr Glu Arg Ala Lys 
        435                 440                 445             


Met Glu Arg Thr Val Ala Glu Ala Lys Arg Gln Ala Ala Glu Asp Ala 
    450                 455                 460                 


Leu Ala Val Ile Asn Gln Gln Glu Asp Ser Ser Glu Ser Cys Trp Asn 
465                 470                 475                 480 


Cys Gly Arg Lys Ala Ser Glu Thr Cys Ser Gly Cys Asn Thr Ala Arg 
                485                 490                 495     


Tyr Cys Gly Ser Phe Cys Gln His Lys Asp Trp Glu Lys His His His 
            500                 505                 510         


Ile Cys Gly Gln Thr Leu Gln Ala Gln Gln Gln Gly Asp Thr Pro Ala 
        515                 520                 525             


Val Ser Ser Ser Val Thr Pro Asn Ser Gly Ala Gly Ser Pro Met Asp 
    530                 535                 540                 


Thr Pro Pro Ala Ala Thr Pro Arg Ser Thr Thr Pro Gly Thr Pro Ser 
545                 550                 555                 560 


Thr Ile Glu Thr Thr Pro Arg 
                565         


<210>  176
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Ile Ser Val Lys Arg Asn Thr Trp Arg Ala Leu Ser Leu Val Ile 
1               5                   10                  15      


Gly Asp Cys Arg Lys Lys Gly Asn Phe Glu Tyr Cys Gln Asp Arg Thr 
            20                  25                  30          


Glu Lys His Ser Thr Met Pro Asp Ser Pro Val Asp Val Lys Thr Gln 
        35                  40                  45              


Ser Arg Leu Thr Pro Pro Thr Met Pro Pro Pro Pro Thr Thr Gln Gly 
    50                  55                  60                  


Ala Pro Arg Thr Ser Ser Phe Thr Pro Thr Thr Leu Thr Asn Gly Thr 
65                  70                  75                  80  


Ser His Ser Pro Thr Ala Leu Asn Gly Ala Pro Ser Pro Pro Asn Gly 
                85                  90                  95      


Phe Ser Asn Gly Pro Ser Ser Ser Ser Ser Ser Ser Leu Ala Asn Gln 
            100                 105                 110         


Gln Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu Ser Lys Leu Lys Arg 
        115                 120                 125             


Phe Leu Thr Thr Leu Gln Gln Phe Gly Asn Asp Ile Ser Pro Glu Ile 
    130                 135                 140                 


Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu Val Asn Ser Thr Leu 
145                 150                 155                 160 


Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu Ala Thr Asn Phe Pro 
                165                 170                 175     


Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn Leu Pro Leu Leu 
            180                 185                 190         


Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala Lys Gln Asn Pro Ala 
        195                 200                 205             


Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu Asp Ala Ser Thr Thr 
    210                 215                 220                 


Ser Pro Val Asp Ser Ser Glu Leu Leu Leu Asp Val Asn Glu Asn Gly 
225                 230                 235                 240 


Lys Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn Gly Phe Asp Arg Glu 
                245                 250                 255     


Pro Leu His Ser Glu His Pro Ser Lys Arg Pro Cys Thr Ile Ser Pro 
            260                 265                 270         


Gly Gln Arg Tyr Ser Pro Asn Asn Gly Leu Ser Tyr Gln Pro Asn Gly 
        275                 280                 285             


Leu Pro His Pro Thr Pro Pro Pro Pro Gln His Tyr Arg Leu Asp Asp 
    290                 295                 300                 


Met Ala Ile Ala His His Tyr Arg Asp Ser Tyr Arg His Pro Ser His 
305                 310                 315                 320 


Arg Asp Leu Arg Asp Arg Asn Arg Pro Met Gly Leu His Gly Thr Arg 
                325                 330                 335     


Gln Glu Glu Met Ile Asp His Arg Leu Thr Asp Arg Glu Trp Ala Glu 
            340                 345                 350         


Glu Trp Lys His Leu Asp His Leu Leu Asn Cys Ile Met Asp Met Val 
        355                 360                 365             


Glu Lys Thr Arg Arg Ser Leu Thr Val Leu Arg Arg Cys Gln Glu Ala 
    370                 375                 380                 


Asp Arg Glu Glu Leu Asn Tyr Trp Ile Arg Arg Tyr Ser Asp Ala Glu 
385                 390                 395                 400 


Asp Leu Lys Lys Gly Gly Gly Ser Ser Ser Ser His Ser Arg Gln Gln 
                405                 410                 415     


Ser Pro Val Asn Pro Asp Pro Val Ala Leu Gly 
            420                 425         


<210>  177
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Pro Asp Arg Thr Glu Lys His Ser Thr Met Pro Asp Ser Pro Val 
1               5                   10                  15      


Asp Val Lys Thr Gln Ser Arg Leu Thr Pro Pro Thr Met Pro Pro Pro 
            20                  25                  30          


Pro Thr Thr Gln Gly Ala Pro Arg Thr Ser Ser Phe Thr Pro Thr Thr 
        35                  40                  45              


Leu Thr Asn Gly Thr Ser His Ser Pro Thr Ala Leu Asn Gly Ala Pro 
    50                  55                  60                  


Ser Pro Pro Asn Gly Phe Ser Asn Gly Pro Ser Ser Ser Ser Ser Ser 
65                  70                  75                  80  


Ser Leu Ala Asn Gln Gln Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu 
                85                  90                  95      


Ser Lys Leu Lys Arg Phe Leu Thr Thr Leu Gln Gln Phe Gly Asn Asp 
            100                 105                 110         


Ile Ser Pro Glu Ile Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu 
        115                 120                 125             


Val Asn Ser Thr Leu Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu 
    130                 135                 140                 


Ala Thr Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala 
145                 150                 155                 160 


Asn Leu Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala 
                165                 170                 175     


Lys Gln Asn Pro Ala Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu 
            180                 185                 190         


Asp Ala Ser Thr Thr Ser Pro Val Asp Ser Ser Glu Leu Leu Leu Asp 
        195                 200                 205             


Val Asn Glu Asn Gly Lys Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn 
    210                 215                 220                 


Gly Phe Asp Arg Glu Pro Leu His Ser Glu His Pro Ser Lys Arg Pro 
225                 230                 235                 240 


Cys Thr Ile Ser Pro Gly Gln Arg Tyr Ser Pro Asn Asn Gly Leu Ser 
                245                 250                 255     


Tyr Gln Pro Asn Gly Leu Pro His Pro Thr Pro Pro Pro Pro Gln His 
            260                 265                 270         


Tyr Arg Leu Asp Asp Met Ala Ile Ala His His Tyr Arg Asp Ser Tyr 
        275                 280                 285             


Arg His Pro Ser His Arg Asp Leu Arg Asp Arg Asn Arg Pro Met Gly 
    290                 295                 300                 


Leu His Gly Thr Arg Gln Glu Glu Met Ile Asp His Arg Leu Thr Asp 
305                 310                 315                 320 


Arg Glu Trp Ala Glu Glu Trp Lys His Leu Asp His Leu Leu Asn Cys 
                325                 330                 335     


Ile Met Asp Met Val Glu Lys Thr Arg Arg Ser Leu Thr Val Leu Arg 
            340                 345                 350         


Arg Cys Gln Glu Ala Asp Arg Glu Glu Leu Asn Tyr Trp Ile Arg Arg 
        355                 360                 365             


Tyr Ser Asp Ala Glu Asp Leu Lys Lys Gly Gly Gly Ser Ser Ser Ser 
    370                 375                 380                 


His Ser Arg Gln Gln Ser Pro Val Asn Pro Asp Pro Val Ala Leu Gly 
385                 390                 395                 400 


<210>  178
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Thr Arg Ala Gly Asp His Asn Arg Gln Arg Gly Cys Cys Gly Ser 
1               5                   10                  15      


Leu Ala Asp Tyr Leu Thr Ser Ala Lys Phe Leu Leu Tyr Leu Gly His 
            20                  25                  30          


Ser Leu Ser Thr Trp Gly Asp Arg Met Trp His Phe Ala Val Ser Val 
        35                  40                  45              


Phe Leu Val Glu Leu Tyr Gly Asn Ser Leu Leu Leu Thr Ala Val Tyr 
    50                  55                  60                  


Gly Leu Val Val Ala Gly Ser Val Leu Val Leu Gly Ala Ile Ile Gly 
65                  70                  75                  80  


Asp Trp Val Asp Lys Asn Ala Arg Leu Lys Val Ala Gln Thr Ser Leu 
                85                  90                  95      


Val Val Gln Asn Val Ser Val Ile Leu Cys Gly Ile Ile Leu Met Met 
            100                 105                 110         


Val Phe Leu His Lys His Glu Leu Leu Thr Met Tyr His Gly Trp Val 
        115                 120                 125             


Leu Thr Ser Cys Tyr Ile Leu Ile Ile Thr Ile Ala Asn Ile Ala Asn 
    130                 135                 140                 


Leu Ala Ser Thr Ala Thr Ala Ile Thr Ile Gln Arg Asp Trp Ile Val 
145                 150                 155                 160 


Val Val Ala Gly Glu Asp Arg Ser Lys Leu Ala Asn Met Asn Ala Thr 
                165                 170                 175     


Ile Arg Arg Ile Asp Gln Leu Thr Asn Ile Leu Ala Pro Met Ala Val 
            180                 185                 190         


Gly Gln Ile Met Thr Phe Gly Ser Pro Val Ile Gly Cys Gly Phe Ile 
        195                 200                 205             


Ser Gly Trp Asn Leu Val Ser Met Cys Val Glu Tyr Val Leu Leu Trp 
    210                 215                 220                 


Lys Val Tyr Gln Lys Thr Pro Ala Leu Ala Val Lys Ala Gly Leu Lys 
225                 230                 235                 240 


Glu Glu Glu Thr Glu Leu Lys Gln Leu Asn Leu His Lys Asp Thr Glu 
                245                 250                 255     


Pro Lys Pro Leu Glu Gly Thr His Leu Met Gly Val Lys Asp Ser Asn 
            260                 265                 270         


Ile His Glu Leu Glu His Glu Gln Glu Pro Thr Cys Ala Ser Gln Met 
        275                 280                 285             


Ala Glu Pro Phe Arg Thr Phe Arg Asp Gly Trp Val Ser Tyr Tyr Asn 
    290                 295                 300                 


Gln Pro Val Phe Leu Ala Gly Met Gly Leu Ala Phe Leu Tyr Met Thr 
305                 310                 315                 320 


Val Leu Gly Phe Asp Cys Ile Thr Thr Gly Tyr Ala Tyr Thr Gln Gly 
                325                 330                 335     


Leu Ser Gly Ser Ile Leu Ser Ile Leu Met Gly Ala Ser Ala Ile Thr 
            340                 345                 350         


Gly Ile Met Gly Thr Val Ala Phe Thr Trp Leu Arg Arg Lys Cys Gly 
        355                 360                 365             


Leu Val Arg Thr Gly Leu Ile Ser Gly Leu Ala Gln Leu Ser Cys Leu 
    370                 375                 380                 


Ile Leu Cys Val Ile Ser Val Phe Met Pro Gly Ser Pro Leu Asp Leu 
385                 390                 395                 400 


Ser Val Ser Pro Phe Glu Asp Ile Arg Ser Arg Phe Ile Gln Gly Glu 
                405                 410                 415     


Ser Ile Thr Pro Thr Lys Ile Pro Glu Ile Thr Thr Glu Ile Tyr Met 
            420                 425                 430         


Ser Asn Gly Ser Asn Ser Ala Asn Ile Val Pro Glu Thr Ser Pro Glu 
        435                 440                 445             


Ser Val Pro Ile Ile Ser Val Ser Leu Leu Phe Ala Gly Val Ile Ala 
    450                 455                 460                 


Ala Arg Ile Gly Leu Trp Ser Phe Asp Leu Thr Val Thr Gln Leu Leu 
465                 470                 475                 480 


Gln Glu Asn Val Ile Glu Ser Glu Arg Gly Ile Ile Asn Gly Val Gln 
                485                 490                 495     


Asn Ser Met Asn Tyr Leu Leu Asp Leu Leu His Phe Ile Met Val Ile 
            500                 505                 510         


Leu Ala Pro Asn Pro Glu Ala Phe Gly Leu Leu Val Leu Ile Ser Val 
        515                 520                 525             


Ser Phe Val Ala Met Gly His Ile Met Tyr Phe Arg Phe Ala Gln Asn 
    530                 535                 540                 


Thr Leu Gly Asn Lys Leu Phe Ala Cys Gly Pro Asp Ala Lys Glu Val 
545                 550                 555                 560 


Arg Lys Glu Asn Gln Ala Asn Thr Ser Val Val 
                565                 570     


<210>  179
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Gly Leu Leu Pro Lys Leu Gly Ala Ser Gln Gly Ser Asp Thr Ser 
1               5                   10                  15      


Thr Ser Arg Ala Gly Arg Cys Ala Arg Ser Val Phe Gly Asn Ile Lys 
            20                  25                  30          


Val Phe Val Leu Cys Gln Gly Leu Leu Gln Leu Cys Gln Leu Leu Tyr 
        35                  40                  45              


Ser Ala Tyr Phe Lys Ser Ser Leu Thr Thr Ile Glu Lys Arg Phe Gly 
    50                  55                  60                  


Leu Ser Ser Ser Ser Ser Gly Leu Ile Ser Ser Leu Asn Glu Ile Ser 
65                  70                  75                  80  


Asn Ala Ile Leu Ile Ile Phe Val Ser Tyr Phe Gly Ser Arg Val His 
                85                  90                  95      


Arg Pro Arg Leu Ile Gly Ile Gly Gly Leu Phe Leu Ala Ala Gly Ala 
            100                 105                 110         


Phe Ile Leu Thr Leu Pro His Phe Leu Ser Glu Pro Tyr Gln Tyr Thr 
        115                 120                 125             


Leu Ala Ser Thr Gly Asn Asn Ser Arg Leu Gln Ala Glu Leu Cys Gln 
    130                 135                 140                 


Lys His Trp Gln Asp Leu Pro Pro Ser Lys Cys His Ser Thr Thr Gln 
145                 150                 155                 160 


Asn Pro Gln Lys Glu Thr Ser Ser Met Trp Gly Leu Met Val Val Ala 
                165                 170                 175     


Gln Leu Leu Ala Gly Ile Gly Thr Val Pro Ile Gln Pro Phe Gly Ile 
            180                 185                 190         


Ser Tyr Val Asp Asp Phe Ser Glu Pro Ser Asn Ser Pro Leu Tyr Ile 
        195                 200                 205             


Ser Ile Leu Phe Ala Ile Ser Val Phe Gly Pro Ala Phe Gly Tyr Leu 
    210                 215                 220                 


Leu Gly Ser Val Met Leu Gln Ile Phe Val Asp Tyr Gly Arg Val Asn 
225                 230                 235                 240 


Thr Ala Ala Val Asn Leu Val Pro Gly Asp Pro Arg Trp Ile Gly Ala 
                245                 250                 255     


Trp Trp Leu Gly Leu Leu Ile Ser Ser Ala Leu Leu Val Leu Thr Ser 
            260                 265                 270         


Phe Pro Phe Phe Phe Phe Pro Arg Ala Met Pro Ile Gly Ala Lys Arg 
        275                 280                 285             


Ala Pro Ala Thr Ala Asp Glu Ala Arg Lys Leu Glu Glu Ala Lys Ser 
    290                 295                 300                 


Arg Gly Ser Leu Val Asp Phe Ile Lys Arg Phe Pro Cys Ile Phe Leu 
305                 310                 315                 320 


Arg Leu Leu Met Asn Ser Leu Phe Val Leu Val Val Leu Ala Gln Cys 
                325                 330                 335     


Thr Phe Ser Ser Val Ile Ala Gly Leu Ser Thr Phe Leu Asn Lys Phe 
            340                 345                 350         


Leu Glu Lys Gln Tyr Gly Thr Ser Ala Ala Tyr Ala Asn Phe Leu Ile 
        355                 360                 365             


Gly Ala Val Asn Leu Pro Ala Ala Ala Leu Gly Met Leu Phe Gly Gly 
    370                 375                 380                 


Ile Leu Met Lys Arg Phe Val Phe Ser Leu Gln Ala Ile Pro Arg Ile 
385                 390                 395                 400 


Ala Thr Thr Ile Ile Thr Ile Ser Met Ile Leu Cys Val Pro Leu Phe 
                405                 410                 415     


Phe Met Gly Cys Ser Thr Pro Thr Val Ala Glu Val Tyr Pro Pro Ser 
            420                 425                 430         


Thr Ser Ser Ser Ile His Pro Gln Ser Pro Ala Cys Arg Arg Asp Cys 
        435                 440                 445             


Ser Cys Pro Asp Ser Ile Phe His Pro Val Cys Gly Asp Asn Gly Ile 
    450                 455                 460                 


Glu Tyr Leu Ser Pro Cys His Ala Gly Cys Ser Asn Ile Asn Met Ser 
465                 470                 475                 480 


Ser Ala Thr Ser Lys Gln Leu Ile Tyr Leu Asn Cys Ser Cys Val Thr 
                485                 490                 495     


Gly Gly Ser Ala Ser Ala Lys Thr Gly Ser Cys Pro Val Pro Cys Ala 
            500                 505                 510         


His Phe Leu Leu Pro Ala Ile Phe Leu Ile Ser Phe Val Ser Leu Ile 
        515                 520                 525             


Ala Cys Ile Ser His Asn Pro Leu Tyr Met Met Val Leu Arg Val Val 
    530                 535                 540                 


Asn Gln Glu Glu Lys Ser Phe Ala Ile Gly Val Gln Phe Leu Leu Met 
545                 550                 555                 560 


Arg Leu Leu Ala Trp Leu Pro Ser Pro Ala Leu Tyr Gly Leu Thr Ile 
                565                 570                 575     


Asp His Ser Cys Ile Arg Trp Asn Ser Leu Cys Leu Gly Arg Arg Gly 
            580                 585                 590         


Ala Cys Ala Tyr Tyr Asp Asn Asp Ala Leu Arg Asp Arg Tyr Leu Gly 
        595                 600                 605             


Leu Gln Met Gly Tyr Lys Ala Leu Gly Met Leu Leu Leu Cys Phe Ile 
    610                 615                 620                 


Ser Trp Arg Val Lys Lys Asn Lys Glu Tyr Asn Val Gln Lys Ala Ala 
625                 630                 635                 640 


Gly Leu Ile 
            


<210>  180
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 
705                 710                 715                 720 


Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg 
                725                 730                 735     


Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val 
            740                 745                 750 


<210>  181
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val 
705                 710         


<210>  182
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Leu Ser Pro Lys Asp Ile Leu Arg Lys Asp Leu Lys Leu Val His 
1               5                   10                  15      


Gly Tyr Pro Met Thr Cys Ala Phe Ala Ser Asn Trp Glu Lys Ile Glu 
            20                  25                  30          


Gln Phe His Ser Arg Pro Asp Asp Ile Val Ile Ala Thr Tyr Pro Lys 
        35                  40                  45              


Ser Gly Thr Thr Trp Val Ser Glu Ile Ile Asp Met Ile Leu Asn Asp 
    50                  55                  60                  


Gly Asp Ile Glu Lys Cys Lys Arg Gly Phe Ile Thr Glu Lys Val Pro 
65                  70                  75                  80  


Met Leu Glu Met Thr Leu Pro Gly Leu Arg Thr Ser Gly Ile Glu Gln 
                85                  90                  95      


Leu Glu Lys Asn Pro Ser Pro Arg Ile Val Lys Thr His Leu Pro Thr 
            100                 105                 110         


Asp Leu Leu Pro Lys Ser Phe Trp Glu Asn Asn Cys Lys Met Ile Tyr 
        115                 120                 125             


Leu Ala Arg Asn Ala Lys Asp Val Ser Val Ser Tyr Tyr His Phe Asp 
    130                 135                 140                 


Leu Met Asn Asn Leu Gln Pro Phe Pro Gly Thr Trp Glu Glu Tyr Leu 
145                 150                 155                 160 


Glu Lys Phe Leu Thr Gly Lys Val Ala Tyr Gly Ser Trp Phe Thr His 
                165                 170                 175     


Val Lys Asn Trp Trp Lys Lys Lys Glu Glu His Pro Ile Leu Phe Leu 
            180                 185                 190         


Tyr Tyr Glu Asp Met Lys Glu Asn Pro Lys Glu Glu Ile Lys Lys Ile 
        195                 200                 205             


Ile Arg Phe Leu Glu Lys Asn Leu Asn Asp Glu Ile Leu Asp Arg Ile 
    210                 215                 220                 


Ile His His Thr Ser Phe Glu Val Met Lys Asp Asn Pro Leu Val Asn 
225                 230                 235                 240 


Tyr Thr His Leu Pro Thr Thr Val Met Asp His Ser Lys Ser Pro Phe 
                245                 250                 255     


Met Arg Lys Gly Thr Ala Gly Asp Trp Lys Asn Tyr Phe Thr Val Ala 
            260                 265                 270         


Gln Asn Glu Lys Phe Asp Ala Ile Tyr Glu Thr Glu Met Ser Lys Thr 
        275                 280                 285             


Ala Leu Gln Phe Arg Thr Glu Ile 
    290                 295     


<210>  183
<211>  1140
<212>  PRT
<213>  Homo sapiens

<400>  183

Met Trp Leu Lys Pro Glu Glu Val Leu Leu Lys Asn Ala Leu Lys Leu 
1               5                   10                  15      


Trp Val Thr Gln Lys Ser Ser Cys Tyr Phe Ile Leu Gln Arg Arg Arg 
            20                  25                  30          


Gly His Gly Glu Gly Gly Gly Arg Leu Thr Gly Arg Leu Val Gly Ala 
        35                  40                  45              


Leu Asp Ala Val Leu Asp Ser Asn Ala Arg Val Ala Pro Phe Arg Ile 
    50                  55                  60                  


Leu Leu Gln Val Pro Gly Ser Gln Val Tyr Ser Pro Ile Ala Cys Gly 
65                  70                  75                  80  


Ala Thr Leu Glu Glu Ile Asn Gln His Trp Asp Trp Leu Glu Gln Asn 
                85                  90                  95      


Leu Leu His Thr Leu Ser Val Phe Asp Asn Lys Asp Asp Ile Ala Ser 
            100                 105                 110         


Phe Val Lys Gly Lys Val Lys Ala Leu Ile Ala Glu Glu Thr Ser Ser 
        115                 120                 125             


Arg Leu Ala Glu Gln Glu Glu Glu Pro Glu Lys Phe Arg Glu Ala Leu 
    130                 135                 140                 


Val Lys Phe Glu Ala Arg Phe Asn Phe Pro Glu Ala Glu Lys Leu Val 
145                 150                 155                 160 


Thr Tyr Tyr Ser Cys Cys Cys Trp Lys Gly Arg Val Pro Arg Gln Gly 
                165                 170                 175     


Trp Leu Tyr Leu Ser Ile Asn His Leu Cys Phe Tyr Ser Phe Phe Leu 
            180                 185                 190         


Gly Lys Glu Leu Lys Leu Val Val Pro Trp Val Asp Ile Gln Lys Leu 
        195                 200                 205             


Glu Arg Thr Ser Asn Val Phe Leu Thr Asp Thr Ile Arg Ile Thr Thr 
    210                 215                 220                 


Gln Asn Lys Glu Arg Asp Phe Ser Met Phe Leu Asn Leu Asp Glu Val 
225                 230                 235                 240 


Phe Lys Val Met Glu Gln Leu Ala Asp Val Thr Leu Arg Arg Leu Leu 
                245                 250                 255     


Asp Asn Glu Val Phe Asp Leu Asp Pro Asp Leu Gln Glu Pro Ser Gln 
            260                 265                 270         


Ile Thr Lys Arg Asp Leu Glu Ala Arg Ala Gln Asn Glu Phe Phe Arg 
        275                 280                 285             


Ala Phe Phe Arg Leu Pro Arg Lys Glu Lys Leu His Ala Val Val Asp 
    290                 295                 300                 


Cys Ser Leu Trp Thr Pro Phe Ser Arg Cys His Thr Thr Gly Arg Met 
305                 310                 315                 320 


Phe Ala Ser Asp Ser Tyr Ile Cys Phe Ala Ser Arg Glu Asp Gly Cys 
                325                 330                 335     


Cys Lys Ile Ile Leu Pro Leu Arg Glu Val Val Ser Ile Glu Lys Met 
            340                 345                 350         


Glu Asp Thr Ser Leu Leu Pro His Pro Ile Ile Val Ser Ile Arg Ser 
        355                 360                 365             


Lys Val Ala Phe Gln Phe Ile Glu Leu Arg Asp Arg Asp Ser Leu Val 
    370                 375                 380                 


Glu Ala Leu Leu Ala Arg Leu Lys Gln Val His Ala Asn His Pro Val 
385                 390                 395                 400 


His Tyr Asp Thr Ser Ala Asp Asp Asp Met Ala Ser Leu Val Phe His 
                405                 410                 415     


Ser Thr Ser Met Cys Ser Asp His Arg Phe Gly Asp Leu Glu Met Met 
            420                 425                 430         


Ser Ser Gln Asn Ser Glu Glu Ser Glu Lys Glu Lys Ser Pro Leu Met 
        435                 440                 445             


His Pro Asp Ala Leu Val Thr Ala Phe Gln Gln Ser Gly Ser Gln Ser 
    450                 455                 460                 


Pro Asp Ser Arg Met Ser Arg Glu Gln Ile Lys Ile Ser Leu Trp Asn 
465                 470                 475                 480 


Asp His Phe Val Glu Tyr Gly Arg Thr Val Cys Met Phe Arg Thr Glu 
                485                 490                 495     


Lys Ile Arg Lys Leu Val Ala Met Gly Ile Pro Glu Ser Leu Arg Gly 
            500                 505                 510         


Arg Leu Trp Leu Leu Phe Ser Asp Ala Val Thr Asp Leu Ala Ser His 
        515                 520                 525             


Pro Gly Tyr Tyr Gly Asn Leu Val Glu Glu Ser Leu Gly Lys Cys Cys 
    530                 535                 540                 


Leu Val Thr Glu Glu Ile Glu Arg Asp Leu His Arg Ser Leu Pro Glu 
545                 550                 555                 560 


His Pro Ala Phe Gln Asn Glu Thr Gly Ile Ala Ala Leu Arg Arg Val 
                565                 570                 575     


Leu Thr Ala Tyr Ala His Arg Asn Pro Lys Ile Gly Tyr Cys Gln Ser 
            580                 585                 590         


Met Asn Ile Leu Thr Ser Val Leu Leu Leu Tyr Thr Lys Glu Glu Glu 
        595                 600                 605             


Ala Phe Trp Leu Leu Val Ala Val Cys Glu Arg Met Leu Pro Asp Tyr 
    610                 615                 620                 


Phe Asn His Arg Val Ile Gly Ala Gln Val Asp Gln Ser Val Phe Glu 
625                 630                 635                 640 


Glu Leu Ile Lys Gly His Leu Pro Glu Leu Ala Glu His Met Asn Asp 
                645                 650                 655     


Leu Ser Ala Leu Ala Ser Val Ser Leu Ser Trp Phe Leu Thr Leu Phe 
            660                 665                 670         


Leu Ser Ile Met Pro Leu Glu Ser Ala Val Asn Val Val Asp Cys Phe 
        675                 680                 685             


Phe Tyr Asp Gly Ile Lys Ala Ile Phe Gln Leu Gly Leu Ala Val Leu 
    690                 695                 700                 


Glu Ala Asn Ala Glu Asp Leu Cys Ser Ser Lys Asp Asp Gly Gln Ala 
705                 710                 715                 720 


Leu Met Ile Leu Ser Arg Phe Leu Asp His Ile Lys Asn Glu Asp Ser 
                725                 730                 735     


Pro Gly Pro Pro Val Gly Ser His His Ala Phe Phe Ser Asp Asp Gln 
            740                 745                 750         


Glu Pro Tyr Pro Val Thr Asp Ile Ser Asp Leu Ile Arg Asp Ser Tyr 
        755                 760                 765             


Glu Lys Phe Gly Asp Gln Ser Val Glu Gln Ile Glu His Leu Arg Tyr 
    770                 775                 780                 


Lys His Arg Ile Arg Val Leu Gln Gly His Glu Asp Thr Thr Lys Gln 
785                 790                 795                 800 


Asn Val Leu Arg Val Val Ile Pro Glu Val Ser Ile Leu Pro Glu Asp 
                805                 810                 815     


Leu Glu Glu Leu Tyr Asp Leu Phe Lys Arg Glu His Met Met Ser Cys 
            820                 825                 830         


Tyr Trp Glu Gln Pro Arg Pro Met Ala Ser Arg His Asp Pro Ser Arg 
        835                 840                 845             


Pro Tyr Ala Glu Gln Tyr Arg Ile Asp Ala Arg Gln Phe Ala His Leu 
    850                 855                 860                 


Phe Gln Leu Val Ser Pro Trp Thr Cys Gly Ala His Thr Glu Ile Leu 
865                 870                 875                 880 


Ala Glu Arg Thr Phe Arg Leu Leu Asp Asp Asn Met Asp Gln Leu Ile 
                885                 890                 895     


Glu Phe Lys Ala Phe Val Ser Cys Leu Asp Ile Met Tyr Asn Gly Glu 
            900                 905                 910         


Met Asn Glu Lys Ile Lys Leu Leu Tyr Arg Leu His Ile Pro Pro Ala 
        915                 920                 925             


Leu Thr Glu Asn Asp Arg Asp Ser Gln Ser Pro Leu Arg Asn Pro Leu 
    930                 935                 940                 


Leu Ser Thr Ser Arg Pro Leu Val Phe Gly Lys Pro Asn Gly Asp Ala 
945                 950                 955                 960 


Val Asp Tyr Gln Lys Gln Leu Lys Gln Met Ile Lys Asp Leu Ala Lys 
                965                 970                 975     


Glu Lys Asp Lys Thr Glu Lys Glu Leu Pro Lys Met Ser Gln Arg Glu 
            980                 985                 990         


Phe Ile Gln Phe Cys Lys Thr Leu  Tyr Ser Met Phe His  Glu Asp Pro 
        995                 1000                 1005             


Glu Glu  Asn Asp Leu Tyr Gln  Ala Ile Ala Thr Val  Thr Thr Leu 
    1010                 1015                 1020             


Leu Leu  Gln Ile Gly Glu Val  Gly Gln Arg Gly Ser  Ser Ser Gly 
    1025                 1030                 1035             


Ser Cys  Ser Gln Glu Cys Gly  Glu Glu Leu Arg Ala  Ser Ala Pro 
    1040                 1045                 1050             


Ser Pro  Glu Asp Ser Val Phe  Ala Asp Thr Gly Lys  Thr Pro Gln 
    1055                 1060                 1065             


Asp Ser  Gln Ala Phe Pro Glu  Ala Ala Glu Arg Asp  Trp Thr Val 
    1070                 1075                 1080             


Ser Leu  Glu His Ile Leu Ala  Ser Leu Leu Thr Glu  Gln Ser Leu 
    1085                 1090                 1095             


Val Asn  Phe Phe Glu Lys Pro  Leu Asp Met Lys Ser  Lys Leu Glu 
    1100                 1105                 1110             


Asn Ala  Lys Ile Asn Gln Tyr  Asn Leu Lys Thr Phe  Glu Met Ser 
    1115                 1120                 1125             


His Gln  Ser Gln Ser Glu Leu  Lys Leu Ser Asn Leu  
    1130                 1135                 1140 


<210>  184
<211>  897
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Glu Gln Leu Ala Asp Val Thr Leu Arg Arg Leu Leu Asp Asn Glu 
1               5                   10                  15      


Val Phe Asp Leu Asp Pro Asp Leu Gln Glu Pro Ser Gln Ile Thr Lys 
            20                  25                  30          


Arg Asp Leu Glu Ala Arg Ala Gln Asn Glu Phe Phe Arg Ala Phe Phe 
        35                  40                  45              


Arg Leu Pro Arg Lys Glu Lys Leu His Ala Val Val Asp Cys Ser Leu 
    50                  55                  60                  


Trp Thr Pro Phe Ser Arg Cys His Thr Thr Gly Arg Met Phe Ala Ser 
65                  70                  75                  80  


Asp Ser Tyr Ile Cys Phe Ala Ser Arg Glu Asp Gly Cys Cys Lys Ile 
                85                  90                  95      


Ile Leu Pro Leu Arg Glu Val Val Ser Ile Glu Lys Met Glu Asp Thr 
            100                 105                 110         


Ser Leu Leu Pro His Pro Ile Ile Val Ser Ile Arg Ser Lys Val Ala 
        115                 120                 125             


Phe Gln Phe Ile Glu Leu Arg Asp Arg Asp Ser Leu Val Glu Ala Leu 
    130                 135                 140                 


Leu Ala Arg Leu Lys Gln Val His Ala Asn His Pro Val His Tyr Asp 
145                 150                 155                 160 


Thr Ser Ala Asp Asp Asp Met Ala Ser Leu Val Phe His Ser Thr Ser 
                165                 170                 175     


Met Cys Ser Asp His Arg Phe Gly Asp Leu Glu Met Met Ser Ser Gln 
            180                 185                 190         


Asn Ser Glu Glu Ser Glu Lys Glu Lys Ser Pro Leu Met His Pro Asp 
        195                 200                 205             


Ala Leu Val Thr Ala Phe Gln Gln Ser Gly Ser Gln Ser Pro Asp Ser 
    210                 215                 220                 


Arg Met Ser Arg Glu Gln Ile Lys Ile Ser Leu Trp Asn Asp His Phe 
225                 230                 235                 240 


Val Glu Tyr Gly Arg Thr Val Cys Met Phe Arg Thr Glu Lys Ile Arg 
                245                 250                 255     


Lys Leu Val Ala Met Gly Ile Pro Glu Ser Leu Arg Gly Arg Leu Trp 
            260                 265                 270         


Leu Leu Phe Ser Asp Ala Val Thr Asp Leu Ala Ser His Pro Gly Tyr 
        275                 280                 285             


Tyr Gly Asn Leu Val Glu Glu Ser Leu Gly Lys Cys Cys Leu Val Thr 
    290                 295                 300                 


Glu Glu Ile Glu Arg Asp Leu His Arg Ser Leu Pro Glu His Pro Ala 
305                 310                 315                 320 


Phe Gln Asn Glu Thr Gly Ile Ala Ala Leu Arg Arg Val Leu Thr Ala 
                325                 330                 335     


Tyr Ala His Arg Asn Pro Lys Ile Gly Tyr Cys Gln Ser Met Asn Ile 
            340                 345                 350         


Leu Thr Ser Val Leu Leu Leu Tyr Thr Lys Glu Glu Glu Ala Phe Trp 
        355                 360                 365             


Leu Leu Val Ala Val Cys Glu Arg Met Leu Pro Asp Tyr Phe Asn His 
    370                 375                 380                 


Arg Val Ile Gly Ala Gln Val Asp Gln Ser Val Phe Glu Glu Leu Ile 
385                 390                 395                 400 


Lys Gly His Leu Pro Glu Leu Ala Glu His Met Asn Asp Leu Ser Ala 
                405                 410                 415     


Leu Ala Ser Val Ser Leu Ser Trp Phe Leu Thr Leu Phe Leu Ser Ile 
            420                 425                 430         


Met Pro Leu Glu Ser Ala Val Asn Val Val Asp Cys Phe Phe Tyr Asp 
        435                 440                 445             


Gly Ile Lys Ala Ile Phe Gln Leu Gly Leu Ala Val Leu Glu Ala Asn 
    450                 455                 460                 


Ala Glu Asp Leu Cys Ser Ser Lys Asp Asp Gly Gln Ala Leu Met Ile 
465                 470                 475                 480 


Leu Ser Arg Phe Leu Asp His Ile Lys Asn Glu Asp Ser Pro Gly Pro 
                485                 490                 495     


Pro Val Gly Ser His His Ala Phe Phe Ser Asp Asp Gln Glu Pro Tyr 
            500                 505                 510         


Pro Val Thr Asp Ile Ser Asp Leu Ile Arg Asp Ser Tyr Glu Lys Phe 
        515                 520                 525             


Gly Asp Gln Ser Val Glu Gln Ile Glu His Leu Arg Tyr Lys His Arg 
    530                 535                 540                 


Ile Arg Val Leu Gln Gly His Glu Asp Thr Thr Lys Gln Asn Val Leu 
545                 550                 555                 560 


Arg Val Val Ile Pro Glu Val Ser Ile Leu Pro Glu Asp Leu Glu Glu 
                565                 570                 575     


Leu Tyr Asp Leu Phe Lys Arg Glu His Met Met Ser Cys Tyr Trp Glu 
            580                 585                 590         


Gln Pro Arg Pro Met Ala Ser Arg His Asp Pro Ser Arg Pro Tyr Ala 
        595                 600                 605             


Glu Gln Tyr Arg Ile Asp Ala Arg Gln Phe Ala His Leu Phe Gln Leu 
    610                 615                 620                 


Val Ser Pro Trp Thr Cys Gly Ala His Thr Glu Ile Leu Ala Glu Arg 
625                 630                 635                 640 


Thr Phe Arg Leu Leu Asp Asp Asn Met Asp Gln Leu Ile Glu Phe Lys 
                645                 650                 655     


Ala Phe Val Ser Cys Leu Asp Ile Met Tyr Asn Gly Glu Met Asn Glu 
            660                 665                 670         


Lys Ile Lys Leu Leu Tyr Arg Leu His Ile Pro Pro Ala Leu Thr Glu 
        675                 680                 685             


Asn Asp Arg Asp Ser Gln Ser Pro Leu Arg Asn Pro Leu Leu Ser Thr 
    690                 695                 700                 


Ser Arg Pro Leu Val Phe Gly Lys Pro Asn Gly Asp Ala Val Asp Tyr 
705                 710                 715                 720 


Gln Lys Gln Leu Lys Gln Met Ile Lys Asp Leu Ala Lys Glu Lys Asp 
                725                 730                 735     


Lys Thr Glu Lys Glu Leu Pro Lys Met Ser Gln Arg Glu Phe Ile Gln 
            740                 745                 750         


Phe Cys Lys Thr Leu Tyr Ser Met Phe His Glu Asp Pro Glu Glu Asn 
        755                 760                 765             


Asp Leu Tyr Gln Ala Ile Ala Thr Val Thr Thr Leu Leu Leu Gln Ile 
    770                 775                 780                 


Gly Glu Val Gly Gln Arg Gly Ser Ser Ser Gly Ser Cys Ser Gln Glu 
785                 790                 795                 800 


Cys Gly Glu Glu Leu Arg Ala Ser Ala Pro Ser Pro Glu Asp Ser Val 
                805                 810                 815     


Phe Ala Asp Thr Gly Lys Thr Pro Gln Asp Ser Gln Ala Phe Pro Glu 
            820                 825                 830         


Ala Ala Glu Arg Asp Trp Thr Val Ser Leu Glu His Ile Leu Ala Ser 
        835                 840                 845             


Leu Leu Thr Glu Gln Ser Leu Val Asn Phe Phe Glu Lys Pro Leu Asp 
    850                 855                 860                 


Met Lys Ser Lys Leu Glu Asn Ala Lys Ile Asn Gln Tyr Asn Leu Lys 
865                 870                 875                 880 


Thr Phe Glu Met Ser His Gln Ser Gln Ser Glu Leu Lys Leu Ser Asn 
                885                 890                 895     


Leu 
    


<210>  185
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Ala Glu Glu Leu Val Leu Glu Arg Cys Asp Leu Glu Leu Glu Thr 
1               5                   10                  15      


Asn Gly Arg Asp His His Thr Ala Asp Leu Cys Arg Glu Lys Leu Val 
            20                  25                  30          


Val Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg 
        35                  40                  45              


Asn Tyr Glu Ala Ser Val Asp Ser Leu Thr Phe Ser Val Val Thr Gly 
    50                  55                  60                  


Pro Ala Pro Ser Gln Glu Ala Gly Thr Lys Ala Arg Phe Pro Leu Arg 
65                  70                  75                  80  


Asp Ala Val Glu Glu Gly Asp Trp Thr Ala Thr Val Val Asp Gln Gln 
                85                  90                  95      


Asp Cys Thr Leu Ser Leu Gln Leu Thr Thr Pro Ala Asn Ala Pro Ile 
            100                 105                 110         


Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser 
        115                 120                 125             


Ser Phe Val Leu Gly His Phe Ile Leu Leu Phe Asn Ala Trp Cys Pro 
    130                 135                 140                 


Ala Asp Ala Val Tyr Leu Asp Ser Glu Glu Glu Arg Gln Glu Tyr Val 
145                 150                 155                 160 


Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Lys 
                165                 170                 175     


Asn Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile 
            180                 185                 190         


Cys Leu Ile Leu Leu Asp Val Asn Pro Lys Phe Leu Lys Asn Ala Gly 
        195                 200                 205             


Arg Asp Cys Ser Arg Arg Ser Ser Pro Val Tyr Val Gly Arg Val Val 
    210                 215                 220                 


Ser Gly Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Leu Gly Arg 
225                 230                 235                 240 


Trp Asp Asn Asn Tyr Gly Asp Gly Val Ser Pro Met Ser Trp Ile Gly 
                245                 250                 255     


Ser Val Asp Ile Leu Arg Arg Trp Lys Asn His Gly Cys Gln Arg Val 
            260                 265                 270         


Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu 
        275                 280                 285             


Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Tyr Asn Ser Ala 
    290                 295                 300                 


His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Phe 
305                 310                 315                 320 


Gly Glu Ile Gln Gly Asp Lys Ser Glu Met Ile Trp Asn Phe His Cys 
                325                 330                 335     


Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Gln Pro Gly Tyr Glu 
            340                 345                 350         


Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr 
        355                 360                 365             


Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly Asp Leu 
    370                 375                 380                 


Ser Thr Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp 
385                 390                 395                 400 


Val Val Asp Trp Ile Gln Gln Asp Asp Gly Ser Val His Lys Ser Ile 
                405                 410                 415     


Asn Arg Ser Leu Ile Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly 
            420                 425                 430         


Arg Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly 
        435                 440                 445             


Ser Ser Glu Glu Arg Glu Ala Phe Thr Arg Ala Asn His Leu Asn Lys 
    450                 455                 460                 


Leu Ala Glu Lys Glu Glu Thr Gly Met Ala Met Arg Ile Arg Val Gly 
465                 470                 475                 480 


Gln Ser Met Asn Met Gly Ser Asp Phe Asp Val Phe Ala His Ile Thr 
                485                 490                 495     


Asn Asn Thr Ala Glu Glu Tyr Val Cys Arg Leu Leu Leu Cys Ala Arg 
            500                 505                 510         


Thr Val Ser Tyr Asn Gly Ile Leu Gly Pro Glu Cys Gly Thr Lys Tyr 
        515                 520                 525             


Leu Leu Asn Leu Asn Leu Glu Pro Phe Ser Glu Lys Ser Val Pro Leu 
    530                 535                 540                 


Cys Ile Leu Tyr Glu Lys Tyr Arg Asp Cys Leu Thr Glu Ser Asn Leu 
545                 550                 555                 560 


Ile Lys Val Arg Ala Leu Leu Val Glu Pro Val Ile Asn Ser Tyr Leu 
                565                 570                 575     


Leu Ala Glu Arg Asp Leu Tyr Leu Glu Asn Pro Glu Ile Lys Ile Arg 
            580                 585                 590         


Ile Leu Gly Glu Pro Lys Gln Lys Arg Lys Leu Val Ala Glu Val Ser 
        595                 600                 605             


Leu Gln Asn Pro Leu Pro Val Ala Leu Glu Gly Cys Thr Phe Thr Val 
    610                 615                 620                 


Glu Gly Ala Gly Leu Thr Glu Glu Gln Lys Thr Val Glu Ile Pro Asp 
625                 630                 635                 640 


Pro Val Glu Ala Gly Glu Glu Val Lys Val Arg Met Asp Leu Leu Pro 
                645                 650                 655     


Leu His Met Gly Leu His Lys Leu Val Val Asn Phe Glu Ser Asp Lys 
            660                 665                 670         


Leu Lys Ala Val Lys Gly Phe Arg Asn Val Ile Ile Gly Pro Ala 
        675                 680                 685         


<210>  186
<211>  548
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Ala Glu Glu Leu Val Leu Glu Arg Cys Asp Leu Glu Leu Glu Thr 
1               5                   10                  15      


Asn Gly Arg Asp His His Thr Ala Asp Leu Cys Arg Glu Lys Leu Val 
            20                  25                  30          


Val Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg 
        35                  40                  45              


Asn Tyr Glu Ala Ser Val Asp Ser Leu Thr Phe Ser Val Val Thr Gly 
    50                  55                  60                  


Pro Ala Pro Ser Gln Glu Ala Gly Thr Lys Ala Arg Phe Pro Leu Arg 
65                  70                  75                  80  


Asp Ala Val Glu Glu Gly Asp Trp Thr Ala Thr Val Val Asp Gln Gln 
                85                  90                  95      


Asp Cys Thr Leu Ser Leu Gln Leu Thr Thr Pro Ala Asn Ala Pro Ile 
            100                 105                 110         


Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser 
        115                 120                 125             


Ser Phe Val Leu Gly His Phe Ile Leu Leu Phe Asn Ala Trp Cys Pro 
    130                 135                 140                 


Ala Asp Ala Val Tyr Leu Asp Ser Glu Glu Glu Arg Gln Glu Tyr Val 
145                 150                 155                 160 


Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Lys 
                165                 170                 175     


Asn Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile 
            180                 185                 190         


Cys Leu Ile Leu Leu Asp Val Asn Pro Lys Phe Leu Lys Asn Ala Gly 
        195                 200                 205             


Arg Asp Cys Ser Arg Arg Ser Ser Pro Val Tyr Val Gly Arg Val Val 
    210                 215                 220                 


Ser Gly Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Leu Gly Arg 
225                 230                 235                 240 


Trp Asp Asn Asn Tyr Gly Asp Gly Val Ser Pro Met Ser Trp Ile Gly 
                245                 250                 255     


Ser Val Asp Ile Leu Arg Arg Trp Lys Asn His Gly Cys Gln Arg Val 
            260                 265                 270         


Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu 
        275                 280                 285             


Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Tyr Asn Ser Ala 
    290                 295                 300                 


His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Phe 
305                 310                 315                 320 


Gly Glu Ile Gln Gly Asp Lys Ser Glu Met Ile Trp Asn Phe His Cys 
                325                 330                 335     


Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Gln Pro Gly Tyr Glu 
            340                 345                 350         


Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr 
        355                 360                 365             


Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly Asp Leu 
    370                 375                 380                 


Ser Thr Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp 
385                 390                 395                 400 


Val Val Asp Trp Ile Gln Gln Asp Asp Gly Ser Val His Lys Ser Ile 
                405                 410                 415     


Asn Arg Ser Leu Ile Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly 
            420                 425                 430         


Arg Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly 
        435                 440                 445             


Ser Ser Glu Glu Arg Glu Ala Phe Thr Arg Ala Asn His Leu Asn Lys 
    450                 455                 460                 


Leu Ala Glu Lys Glu Glu Thr Gly Met Ala Met Arg Ile Arg Val Gly 
465                 470                 475                 480 


Gln Ser Met Asn Met Gly Ser Asp Phe Asp Val Phe Ala His Ile Thr 
                485                 490                 495     


Asn Asn Thr Ala Glu Glu Tyr Val Cys Arg Leu Leu Leu Cys Ala Arg 
            500                 505                 510         


Thr Val Ser Tyr Asn Gly Ile Leu Gly Pro Glu Cys Gly Thr Lys Tyr 
        515                 520                 525             


Leu Leu Asn Leu Asn Leu Glu Pro Phe Ser Gly Lys Ala Leu Cys Ser 
    530                 535                 540                 


Trp Ser Ile Cys 
545             


<210>  187
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Ala Glu Glu Leu Val Leu Glu Arg Cys Asp Leu Glu Leu Glu Thr 
1               5                   10                  15      


Asn Gly Arg Asp His His Thr Ala Asp Leu Cys Arg Glu Lys Leu Val 
            20                  25                  30          


Val Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg 
        35                  40                  45              


Asn Tyr Glu Ala Ser Val Asp Ser Leu Thr Phe Ser Val Val Thr Gly 
    50                  55                  60                  


Pro Ala Pro Ser Gln Glu Ala Gly Thr Lys Ala Arg Phe Pro Leu Arg 
65                  70                  75                  80  


Asp Ala Val Glu Glu Gly Asp Trp Thr Ala Thr Val Val Asp Gln Gln 
                85                  90                  95      


Asp Cys Thr Leu Ser Leu Gln Leu Thr Thr Pro Ala Asn Ala Pro Ile 
            100                 105                 110         


Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser 
        115                 120                 125             


Ser Phe Val Leu Gly His Phe Ile Leu Leu Phe Asn Ala Trp Cys Pro 
    130                 135                 140                 


Ala Asp Ala Val Tyr Leu Asp Ser Glu Glu Glu Arg Gln Glu Tyr Val 
145                 150                 155                 160 


Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Lys 
                165                 170                 175     


Asn Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile 
            180                 185                 190         


Cys Leu Ile Leu Leu Asp Val Asn Pro Lys Phe Leu Lys Asn Ala Gly 
        195                 200                 205             


Arg Asp Cys Ser Arg Arg Ser Ser Pro Val Tyr Val Gly Arg Val Val 
    210                 215                 220                 


Ser Gly Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Leu Gly Arg 
225                 230                 235                 240 


Trp Asp Asn Asn Tyr Gly Asp Gly Val Ser Pro Met Ser Trp Ile Gly 
                245                 250                 255     


Ser Val Asp Ile Leu Arg Arg Trp Lys Asn His Gly Cys Gln Arg Val 
            260                 265                 270         


Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Gly Glu 
        275                 280                 285             


Leu His Ala Gly Met Trp Val Met Ser Pro Gly Arg Gly His Glu Glu 
    290                 295                 300                 


His Trp Ser Arg Asn Gln Asp Ile Pro Ala Leu Val Leu Pro Pro Ala 
305                 310                 315                 320 


Thr Asn Thr Leu Asn Ala Leu Cys Gly Leu Glu Pro Val Thr Thr Leu 
                325                 330                 335     


Ser Gly Pro Leu Ser Asn Ser His Pro Ser Ser Gly Cys 
            340                 345                 


<210>  188
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Ser Pro Arg Ser Cys Leu Arg Ser Leu Arg Leu Leu Val Phe Ala 
1               5                   10                  15      


Val Phe Ser Ala Ala Ala Ser Asn Trp Leu Tyr Leu Ala Lys Leu Ser 
            20                  25                  30          


Ser Val Gly Ser Ile Ser Glu Glu Glu Thr Cys Glu Lys Leu Lys Gly 
        35                  40                  45              


Leu Ile Gln Arg Gln Val Gln Met Cys Lys Arg Asn Leu Glu Val Met 
    50                  55                  60                  


Asp Ser Val Arg Arg Gly Ala Gln Leu Ala Ile Glu Glu Cys Gln Tyr 
65                  70                  75                  80  


Gln Phe Arg Asn Arg Arg Trp Asn Cys Ser Thr Leu Asp Ser Leu Pro 
                85                  90                  95      


Val Phe Gly Lys Val Val Thr Gln Gly Thr Arg Glu Ala Ala Phe Val 
            100                 105                 110         


Tyr Ala Ile Ser Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ala Cys 
        115                 120                 125             


Ser Ser Gly Glu Leu Glu Lys Cys Gly Cys Asp Arg Thr Val His Gly 
    130                 135                 140                 


Val Ser Pro Gln Gly Phe Gln Trp Ser Gly Cys Ser Asp Asn Ile Ala 
145                 150                 155                 160 


Tyr Gly Val Ala Phe Ser Gln Ser Phe Val Asp Val Arg Glu Arg Ser 
                165                 170                 175     


Lys Gly Ala Ser Ser Ser Arg Ala Leu Met Asn Leu His Asn Asn Glu 
            180                 185                 190         


Ala Gly Arg Lys Ala Ile Leu Thr His Met Arg Val Glu Cys Lys Cys 
        195                 200                 205             


His Gly Val Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Arg Ala Val 
    210                 215                 220                 


Pro Pro Phe Arg Gln Val Gly His Ala Leu Lys Glu Lys Phe Asp Gly 
225                 230                 235                 240 


Ala Thr Glu Val Glu Pro Arg Arg Val Gly Ser Ser Arg Ala Leu Val 
                245                 250                 255     


Pro Arg Asn Ala Gln Phe Lys Pro His Thr Asp Glu Asp Leu Val Tyr 
            260                 265                 270         


Leu Glu Pro Ser Pro Asp Phe Cys Glu Gln Asp Met Arg Ser Gly Val 
        275                 280                 285             


Leu Gly Thr Arg Gly Arg Thr Cys Asn Lys Thr Ser Lys Ala Ile Asp 
    290                 295                 300                 


Gly Cys Glu Leu Leu Cys Cys Gly Arg Gly Phe His Thr Ala Gln Val 
305                 310                 315                 320 


Glu Leu Ala Glu Arg Cys Ser Cys Lys Phe His Trp Cys Cys Phe Val 
                325                 330                 335     


Lys Cys Arg Gln Cys Gln Arg Leu Val Glu Leu His Thr Cys Arg 
            340                 345                 350     


<210>  189
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Cys Lys Arg Asn Leu Glu Val Met Asp Ser Val Arg Arg Gly Ala 
1               5                   10                  15      


Gln Leu Ala Ile Glu Glu Cys Gln Tyr Gln Phe Arg Asn Arg Arg Trp 
            20                  25                  30          


Asn Cys Ser Thr Leu Asp Ser Leu Pro Val Phe Gly Lys Val Val Thr 
        35                  40                  45              


Gln Gly Thr Arg Glu Ala Ala Phe Val Tyr Ala Ile Ser Ser Ala Gly 
    50                  55                  60                  


Val Ala Phe Ala Val Thr Arg Ala Cys Ser Ser Gly Glu Leu Glu Lys 
65                  70                  75                  80  


Cys Gly Cys Asp Arg Thr Val His Gly Val Ser Pro Gln Gly Phe Gln 
                85                  90                  95      


Trp Ser Gly Cys Ser Asp Asn Ile Ala Tyr Gly Val Ala Phe Ser Gln 
            100                 105                 110         


Ser Phe Val Asp Val Arg Glu Arg Ser Lys Gly Ala Ser Ser Ser Arg 
        115                 120                 125             


Ala Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ala Ile Leu 
    130                 135                 140                 


Thr His Met Arg Val Glu Cys Lys Cys His Gly Val Ser Gly Ser Cys 
145                 150                 155                 160 


Glu Val Lys Thr Cys Trp Arg Ala Val Pro Pro Phe Arg Gln Val Gly 
                165                 170                 175     


His Ala Leu Lys Glu Lys Phe Asp Gly Ala Thr Glu Val Glu Pro Arg 
            180                 185                 190         


Arg Val Gly Ser Ser Arg Ala Leu Val Pro Arg Asn Ala Gln Phe Lys 
        195                 200                 205             


Pro His Thr Asp Glu Asp Leu Val Tyr Leu Glu Pro Ser Pro Asp Phe 
    210                 215                 220                 


Cys Glu Gln Asp Met Arg Ser Gly Val Leu Gly Thr Arg Gly Arg Thr 
225                 230                 235                 240 


Cys Asn Lys Thr Ser Lys Ala Ile Asp Gly Cys Glu Leu Leu Cys Cys 
                245                 250                 255     


Gly Arg Gly Phe His Thr Ala Gln Val Glu Leu Ala Glu Arg Cys Ser 
            260                 265                 270         


Cys Lys Phe His Trp Cys Cys Phe Val Lys Cys Arg Gln Cys Gln Arg 
        275                 280                 285             


Leu Val Glu Leu His Thr Cys Arg 
    290                 295     


<210>  190
<211>  1279
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Ala Ser Ser Asn Pro Pro Pro Gln Pro Ala Ile Gly Asp Gln Leu 
1               5                   10                  15      


Val Pro Gly Val Pro Gly Pro Ser Ser Glu Ala Glu Asp Asp Pro Gly 
            20                  25                  30          


Glu Ala Phe Glu Phe Asp Asp Ser Asp Asp Glu Glu Asp Thr Ser Ala 
        35                  40                  45              


Ala Leu Gly Val Pro Ser Leu Ala Pro Glu Arg Asp Thr Asp Pro Pro 
    50                  55                  60                  


Leu Ile His Leu Asp Ser Ile Pro Val Thr Asp Pro Asp Pro Ala Ala 
65                  70                  75                  80  


Ala Pro Pro Gly Thr Gly Val Pro Ala Trp Val Ser Asn Gly Asp Ala 
                85                  90                  95      


Ala Asp Ala Ala Phe Ser Gly Ala Arg His Ser Ser Trp Lys Arg Lys 
            100                 105                 110         


Ser Ser Arg Arg Ile Asp Arg Phe Thr Phe Pro Ala Leu Glu Glu Asp 
        115                 120                 125             


Val Ile Tyr Asp Asp Val Pro Cys Glu Ser Pro Asp Ala His Gln Pro 
    130                 135                 140                 


Gly Ala Glu Arg Asn Leu Leu Tyr Glu Asp Ala His Arg Ala Gly Ala 
145                 150                 155                 160 


Pro Arg Gln Ala Glu Asp Leu Gly Trp Ser Ser Ser Glu Phe Glu Ser 
                165                 170                 175     


Tyr Ser Glu Asp Ser Gly Glu Glu Ala Lys Pro Glu Val Glu Val Glu 
            180                 185                 190         


Pro Ala Lys His Arg Val Ser Phe Gln Pro Lys Leu Ser Pro Asp Leu 
        195                 200                 205             


Thr Arg Leu Lys Glu Arg Tyr Ala Arg Thr Lys Arg Asp Ile Leu Ala 
    210                 215                 220                 


Leu Arg Val Gly Gly Arg Asp Met Gln Glu Leu Lys His Lys Tyr Asp 
225                 230                 235                 240 


Cys Lys Met Thr Gln Leu Met Lys Ala Ala Lys Ser Gly Thr Lys Asp 
                245                 250                 255     


Gly Leu Glu Lys Thr Arg Met Ala Val Met Arg Lys Val Ser Phe Leu 
            260                 265                 270         


His Arg Lys Asp Val Leu Gly Asp Ser Glu Glu Glu Asp Met Gly Leu 
        275                 280                 285             


Leu Glu Val Ser Val Ser Asp Ile Lys Pro Pro Ala Pro Glu Leu Gly 
    290                 295                 300                 


Pro Met Pro Glu Gly Leu Ser Pro Gln Gln Val Val Arg Arg His Ile 
305                 310                 315                 320 


Leu Gly Ser Ile Val Gln Ser Glu Gly Ser Tyr Val Glu Ser Leu Lys 
                325                 330                 335     


Arg Ile Leu Gln Asp Tyr Arg Asn Pro Leu Met Glu Met Glu Pro Lys 
            340                 345                 350         


Ala Leu Ser Ala Arg Lys Cys Gln Val Val Phe Phe Arg Val Lys Glu 
        355                 360                 365             


Ile Leu His Cys His Ser Met Phe Gln Ile Ala Leu Ser Ser Arg Val 
    370                 375                 380                 


Ala Glu Trp Asp Ser Thr Glu Lys Ile Gly Asp Leu Phe Val Ala Ser 
385                 390                 395                 400 


Phe Ser Lys Ser Met Val Leu Asp Val Tyr Ser Asp Tyr Val Asn Asn 
                405                 410                 415     


Phe Thr Ser Ala Met Ser Ile Ile Lys Lys Ala Cys Leu Thr Lys Pro 
            420                 425                 430         


Ala Phe Leu Glu Phe Leu Lys Arg Arg Gln Val Cys Ser Pro Asp Arg 
        435                 440                 445             


Val Thr Leu Tyr Gly Leu Met Val Lys Pro Ile Gln Arg Phe Pro Gln 
    450                 455                 460                 


Phe Ile Leu Leu Leu Gln Asp Met Leu Lys Asn Thr Pro Arg Gly His 
465                 470                 475                 480 


Pro Asp Arg Leu Ser Leu Gln Leu Ala Leu Thr Glu Leu Glu Thr Leu 
                485                 490                 495     


Ala Glu Lys Leu Asn Glu Gln Lys Arg Leu Ala Asp Gln Val Ala Glu 
            500                 505                 510         


Ile Gln Gln Leu Thr Lys Ser Val Ser Asp Arg Ser Ser Leu Asn Lys 
        515                 520                 525             


Leu Leu Thr Ser Gly Gln Arg Gln Leu Leu Leu Cys Glu Thr Leu Thr 
    530                 535                 540                 


Glu Thr Val Tyr Gly Asp Arg Gly Gln Leu Ile Lys Ser Lys Glu Arg 
545                 550                 555                 560 


Arg Val Phe Leu Leu Asn Asp Met Leu Val Cys Ala Asn Ile Asn Phe 
                565                 570                 575     


Lys Pro Ala Asn His Arg Gly Gln Leu Glu Ile Ser Ser Leu Val Pro 
            580                 585                 590         


Leu Gly Pro Lys Tyr Val Val Lys Trp Asn Thr Ala Leu Pro Gln Val 
        595                 600                 605             


Gln Val Val Glu Val Gly Gln Asp Gly Gly Thr Tyr Asp Lys Asp Asn 
    610                 615                 620                 


Val Leu Ile Gln His Ser Gly Ala Lys Lys Ala Ser Ala Ser Gly Gln 
625                 630                 635                 640 


Ala Gln Asn Lys Val Tyr Leu Gly Pro Pro Arg Leu Phe Gln Glu Leu 
                645                 650                 655     


Gln Asp Leu Gln Lys Asp Leu Ala Val Val Glu Gln Ile Thr Leu Leu 
            660                 665                 670         


Ile Ser Thr Leu His Gly Thr Tyr Gln Asn Leu Asn Met Thr Val Ala 
        675                 680                 685             


Gln Asp Trp Cys Leu Ala Leu Gln Arg Leu Met Arg Val Lys Glu Glu 
    690                 695                 700                 


Glu Ile His Ser Ala Asn Lys Cys Arg Leu Arg Leu Leu Leu Pro Gly 
705                 710                 715                 720 


Lys Pro Asp Lys Ser Gly Arg Pro Ile Ser Phe Met Val Val Phe Ile 
                725                 730                 735     


Thr Pro Asn Pro Leu Ser Lys Ile Ser Trp Val Asn Arg Leu His Leu 
            740                 745                 750         


Ala Lys Ile Gly Leu Arg Glu Glu Asn Gln Pro Gly Trp Leu Cys Pro 
        755                 760                 765             


Asp Glu Asp Lys Lys Ser Lys Ala Pro Phe Trp Cys Pro Ile Leu Ala 
    770                 775                 780                 


Cys Cys Ile Pro Ala Phe Ser Ser Arg Ala Leu Ser Leu Gln Leu Gly 
785                 790                 795                 800 


Ala Leu Val His Ser Pro Val Asn Cys Pro Leu Leu Gly Phe Ser Ala 
                805                 810                 815     


Val Ser Thr Ser Leu Pro Gln Gly Tyr Leu Trp Val Gly Gly Gly Gln 
            820                 825                 830         


Glu Gly Ala Gly Gly Gln Val Glu Ile Phe Ser Leu Asn Arg Pro Ser 
        835                 840                 845             


Pro Arg Thr Val Lys Ser Phe Pro Leu Ala Ala Pro Val Leu Cys Met 
    850                 855                 860                 


Glu Tyr Ile Pro Glu Leu Glu Glu Glu Ala Glu Ser Arg Asp Glu Ser 
865                 870                 875                 880 


Pro Thr Val Ala Asp Pro Ser Ala Thr Val His Pro Thr Ile Cys Leu 
                885                 890                 895     


Gly Leu Gln Asp Gly Ser Ile Leu Leu Tyr Ser Ser Val Asp Thr Gly 
            900                 905                 910         


Thr Gln Cys Leu Val Ser Cys Arg Ser Pro Gly Leu Gln Pro Val Leu 
        915                 920                 925             


Cys Leu Arg His Ser Pro Phe His Leu Leu Ala Gly Leu Gln Asp Gly 
    930                 935                 940                 


Thr Leu Ala Ala Tyr Pro Arg Thr Ser Gly Gly Val Leu Trp Asp Leu 
945                 950                 955                 960 


Glu Ser Pro Pro Val Cys Leu Thr Val Gly Pro Gly Pro Val Arg Thr 
                965                 970                 975     


Leu Leu Ser Leu Glu Asp Ala Val Trp Ala Ser Cys Gly Pro Arg Val 
            980                 985                 990         


Thr Val Leu Glu Ala Thr Thr Leu  Gln Pro Gln Gln Ser  Phe Glu Ala 
        995                 1000                 1005             


His Gln  Asp Glu Ala Val Ser  Val Thr His Met Val  Lys Ala Gly 
    1010                 1015                 1020             


Ser Gly  Val Trp Met Ala Phe  Ser Ser Gly Thr Ser  Ile Arg Leu 
    1025                 1030                 1035             


Phe His  Thr Glu Thr Leu Glu  His Leu Gln Glu Ile  Asn Ile Ala 
    1040                 1045                 1050             


Thr Arg  Thr Thr Phe Leu Leu  Pro Gly Gln Lys His  Leu Cys Val 
    1055                 1060                 1065             


Thr Ser  Leu Leu Ile Cys Gln  Gly Leu Leu Trp Val  Gly Thr Asp 
    1070                 1075                 1080             


Gln Gly  Val Ile Val Leu Leu  Pro Val Pro Arg Leu  Glu Gly Ile 
    1085                 1090                 1095             


Pro Lys  Ile Thr Gly Lys Gly  Met Val Ser Leu Asn  Gly His Cys 
    1100                 1105                 1110             


Gly Pro  Val Ala Phe Leu Ala  Val Ala Thr Ser Ile  Leu Ala Pro 
    1115                 1120                 1125             


Asp Ile  Leu Arg Ser Asp Gln  Glu Glu Ala Glu Gly  Pro Arg Ala 
    1130                 1135                 1140             


Glu Glu  Asp Lys Pro Asp Gly  Gln Ala His Glu Pro  Met Pro Asp 
    1145                 1150                 1155             


Ser His  Val Gly Arg Glu Leu  Thr Arg Lys Lys Gly  Ile Leu Leu 
    1160                 1165                 1170             


Gln Tyr  Arg Leu Arg Ser Thr  Ala His Leu Pro Gly  Pro Leu Leu 
    1175                 1180                 1185             


Ser Met  Arg Glu Pro Ala Pro  Ala Asp Gly Ala Ala  Leu Glu His 
    1190                 1195                 1200             


Ser Glu  Glu Asp Gly Ser Ile  Tyr Glu Met Ala Asp  Asp Pro Asp 
    1205                 1210                 1215             


Ile Trp  Val Arg Ser Arg Pro  Cys Ala Arg Asp Ala  His Arg Lys 
    1220                 1225                 1230             


Glu Ile  Cys Ser Val Ala Ile  Ile Ser Gly Gly Gln  Gly Tyr Arg 
    1235                 1240                 1245             


Asn Phe  Gly Ser Ala Leu Gly  Ser Ser Gly Arg Gln  Ala Pro Cys 
    1250                 1255                 1260             


Gly Glu  Thr Asp Ser Thr Leu  Leu Ile Trp Gln Val  Pro Leu Met 
    1265                 1270                 1275             


Leu 
    


<210>  191
<211>  1240
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Ala Ser Ser Asn Pro Pro Pro Gln Pro Ala Ile Gly Asp Gln Leu 
1               5                   10                  15      


Val Pro Gly Val Pro Gly Pro Ser Ser Glu Ala Glu Asp Asp Pro Gly 
            20                  25                  30          


Glu Ala Phe Glu Phe Asp Asp Ser Asp Asp Glu Glu Asp Thr Ser Ala 
        35                  40                  45              


Ala Leu Gly Val Pro Ser Leu Ala Pro Glu Arg Asp Thr Asp Pro Pro 
    50                  55                  60                  


Leu Ile His Leu Asp Ser Ile Pro Val Thr Asp Pro Asp Pro Ala Ala 
65                  70                  75                  80  


Ala Pro Pro Gly Thr Gly Val Pro Ala Trp Val Ser Asn Gly Asp Ala 
                85                  90                  95      


Ala Asp Ala Ala Phe Ser Gly Ala Arg His Ser Ser Trp Lys Arg Lys 
            100                 105                 110         


Ser Ser Arg Arg Ile Asp Arg Phe Thr Phe Pro Ala Leu Glu Glu Asp 
        115                 120                 125             


Val Ile Tyr Asp Asp Val Pro Cys Glu Ser Pro Asp Ala His Gln Pro 
    130                 135                 140                 


Gly Ala Glu Arg Asn Leu Leu Tyr Glu Asp Ala His Arg Ala Gly Ala 
145                 150                 155                 160 


Pro Arg Gln Ala Glu Asp Leu Gly Trp Ser Ser Ser Glu Phe Glu Ser 
                165                 170                 175     


Tyr Ser Glu Asp Ser Gly Glu Glu Ala Lys Pro Glu Val Glu Val Glu 
            180                 185                 190         


Pro Ala Lys His Arg Val Ser Phe Gln Pro Lys Met Thr Gln Leu Met 
        195                 200                 205             


Lys Ala Ala Lys Ser Gly Thr Lys Asp Gly Leu Glu Lys Thr Arg Met 
    210                 215                 220                 


Ala Val Met Arg Lys Val Ser Phe Leu His Arg Lys Asp Val Leu Gly 
225                 230                 235                 240 


Asp Ser Glu Glu Glu Asp Met Gly Leu Leu Glu Val Ser Val Ser Asp 
                245                 250                 255     


Ile Lys Pro Pro Ala Pro Glu Leu Gly Pro Met Pro Glu Gly Leu Ser 
            260                 265                 270         


Pro Gln Gln Val Val Arg Arg His Ile Leu Gly Ser Ile Val Gln Ser 
        275                 280                 285             


Glu Gly Ser Tyr Val Glu Ser Leu Lys Arg Ile Leu Gln Asp Tyr Arg 
    290                 295                 300                 


Asn Pro Leu Met Glu Met Glu Pro Lys Ala Leu Ser Ala Arg Lys Cys 
305                 310                 315                 320 


Gln Val Val Phe Phe Arg Val Lys Glu Ile Leu His Cys His Ser Met 
                325                 330                 335     


Phe Gln Ile Ala Leu Ser Ser Arg Val Ala Glu Trp Asp Ser Thr Glu 
            340                 345                 350         


Lys Ile Gly Asp Leu Phe Val Ala Ser Phe Ser Lys Ser Met Val Leu 
        355                 360                 365             


Asp Val Tyr Ser Asp Tyr Val Asn Asn Phe Thr Ser Ala Met Ser Ile 
    370                 375                 380                 


Ile Lys Lys Ala Cys Leu Thr Lys Pro Ala Phe Leu Glu Phe Leu Lys 
385                 390                 395                 400 


Arg Arg Gln Val Cys Ser Pro Asp Arg Val Thr Leu Tyr Gly Leu Met 
                405                 410                 415     


Val Lys Pro Ile Gln Arg Phe Pro Gln Phe Ile Leu Leu Leu Gln Asp 
            420                 425                 430         


Met Leu Lys Asn Thr Pro Arg Gly His Pro Asp Arg Leu Ser Leu Gln 
        435                 440                 445             


Leu Ala Leu Thr Glu Leu Glu Thr Leu Ala Glu Lys Leu Asn Glu Gln 
    450                 455                 460                 


Lys Arg Leu Ala Asp Gln Val Ala Glu Ile Gln Gln Leu Thr Lys Ser 
465                 470                 475                 480 


Val Ser Asp Arg Ser Ser Leu Asn Lys Leu Leu Thr Ser Gly Gln Arg 
                485                 490                 495     


Gln Leu Leu Leu Cys Glu Thr Leu Thr Glu Thr Val Tyr Gly Asp Arg 
            500                 505                 510         


Gly Gln Leu Ile Lys Ser Lys Glu Arg Arg Val Phe Leu Leu Asn Asp 
        515                 520                 525             


Met Leu Val Cys Ala Asn Ile Asn Phe Lys Pro Ala Asn His Arg Gly 
    530                 535                 540                 


Gln Leu Glu Ile Ser Ser Leu Val Pro Leu Gly Pro Lys Tyr Val Val 
545                 550                 555                 560 


Lys Trp Asn Thr Ala Leu Pro Gln Val Gln Val Val Glu Val Gly Gln 
                565                 570                 575     


Asp Gly Gly Thr Tyr Asp Lys Asp Asn Val Leu Ile Gln His Ser Gly 
            580                 585                 590         


Ala Lys Lys Ala Ser Ala Ser Gly Gln Ala Gln Asn Lys Val Tyr Leu 
        595                 600                 605             


Gly Pro Pro Arg Leu Phe Gln Glu Leu Gln Asp Leu Gln Lys Asp Leu 
    610                 615                 620                 


Ala Val Val Glu Gln Ile Thr Leu Leu Ile Ser Thr Leu His Gly Thr 
625                 630                 635                 640 


Tyr Gln Asn Leu Asn Met Thr Val Ala Gln Asp Trp Cys Leu Ala Leu 
                645                 650                 655     


Gln Arg Leu Met Arg Val Lys Glu Glu Glu Ile His Ser Ala Asn Lys 
            660                 665                 670         


Cys Arg Leu Arg Leu Leu Leu Pro Gly Lys Pro Asp Lys Ser Gly Arg 
        675                 680                 685             


Pro Ile Ser Phe Met Val Val Phe Ile Thr Pro Asn Pro Leu Ser Lys 
    690                 695                 700                 


Ile Ser Trp Val Asn Arg Leu His Leu Ala Lys Ile Gly Leu Arg Glu 
705                 710                 715                 720 


Glu Asn Gln Pro Gly Trp Leu Cys Pro Asp Glu Asp Lys Lys Ser Lys 
                725                 730                 735     


Ala Pro Phe Trp Cys Pro Ile Leu Ala Cys Cys Ile Pro Ala Phe Ser 
            740                 745                 750         


Ser Arg Ala Leu Ser Leu Gln Leu Gly Ala Leu Val His Ser Pro Val 
        755                 760                 765             


Asn Cys Pro Leu Leu Gly Phe Ser Ala Val Ser Thr Ser Leu Pro Gln 
    770                 775                 780                 


Gly Tyr Leu Trp Val Gly Gly Gly Gln Glu Gly Ala Gly Gly Gln Val 
785                 790                 795                 800 


Glu Ile Phe Ser Leu Asn Arg Pro Ser Pro Arg Thr Val Lys Ser Phe 
                805                 810                 815     


Pro Leu Ala Ala Pro Val Leu Cys Met Glu Tyr Ile Pro Glu Leu Glu 
            820                 825                 830         


Glu Glu Ala Glu Ser Arg Asp Glu Ser Pro Thr Val Ala Asp Pro Ser 
        835                 840                 845             


Ala Thr Val His Pro Thr Ile Cys Leu Gly Leu Gln Asp Gly Ser Ile 
    850                 855                 860                 


Leu Leu Tyr Ser Ser Val Asp Thr Gly Thr Gln Cys Leu Val Ser Cys 
865                 870                 875                 880 


Arg Ser Pro Gly Leu Gln Pro Val Leu Cys Leu Arg His Ser Pro Phe 
                885                 890                 895     


His Leu Leu Ala Gly Leu Gln Asp Gly Thr Leu Ala Ala Tyr Pro Arg 
            900                 905                 910         


Thr Ser Gly Gly Val Leu Trp Asp Leu Glu Ser Pro Pro Val Cys Leu 
        915                 920                 925             


Thr Val Gly Pro Gly Pro Val Arg Thr Leu Leu Ser Leu Glu Asp Ala 
    930                 935                 940                 


Val Trp Ala Ser Cys Gly Pro Arg Val Thr Val Leu Glu Ala Thr Thr 
945                 950                 955                 960 


Leu Gln Pro Gln Gln Ser Phe Glu Ala His Gln Asp Glu Ala Val Ser 
                965                 970                 975     


Val Thr His Met Val Lys Ala Gly Ser Gly Val Trp Met Ala Phe Ser 
            980                 985                 990         


Ser Gly Thr Ser Ile Arg Leu Phe  His Thr Glu Thr Leu  Glu His Leu 
        995                 1000                 1005             


Gln Glu  Ile Asn Ile Ala Thr  Arg Thr Thr Phe Leu  Leu Pro Gly 
    1010                 1015                 1020             


Gln Lys  His Leu Cys Val Thr  Ser Leu Leu Ile Cys  Gln Gly Leu 
    1025                 1030                 1035             


Leu Trp  Val Gly Thr Asp Gln  Gly Val Ile Val Leu  Leu Pro Val 
    1040                 1045                 1050             


Pro Arg  Leu Glu Gly Ile Pro  Lys Ile Thr Gly Lys  Gly Met Val 
    1055                 1060                 1065             


Ser Leu  Asn Gly His Cys Gly  Pro Val Ala Phe Leu  Ala Val Ala 
    1070                 1075                 1080             


Thr Ser  Ile Leu Ala Pro Asp  Ile Leu Arg Ser Asp  Gln Glu Glu 
    1085                 1090                 1095             


Ala Glu  Gly Pro Arg Ala Glu  Glu Asp Lys Pro Asp  Gly Gln Ala 
    1100                 1105                 1110             


His Glu  Pro Met Pro Asp Ser  His Val Gly Arg Glu  Leu Thr Arg 
    1115                 1120                 1125             


Lys Lys  Gly Ile Leu Leu Gln  Tyr Arg Leu Arg Ser  Thr Ala His 
    1130                 1135                 1140             


Leu Pro  Gly Pro Leu Leu Ser  Met Arg Glu Pro Ala  Pro Ala Asp 
    1145                 1150                 1155             


Gly Ala  Ala Leu Glu His Ser  Glu Glu Asp Gly Ser  Ile Tyr Glu 
    1160                 1165                 1170             


Met Ala  Asp Asp Pro Asp Ile  Trp Val Arg Ser Arg  Pro Cys Ala 
    1175                 1180                 1185             


Arg Asp  Ala His Arg Lys Glu  Ile Cys Ser Val Ala  Ile Ile Ser 
    1190                 1195                 1200             


Gly Gly  Gln Gly Tyr Arg Asn  Phe Gly Ser Ala Leu  Gly Ser Ser 
    1205                 1210                 1215             


Gly Arg  Gln Ala Pro Cys Gly  Glu Thr Asp Ser Thr  Leu Leu Ile 
    1220                 1225                 1230             


Trp Gln  Val Pro Leu Met Leu  
    1235                 1240 


<210>  192
<211>  1235
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Ala Ser Ser Asn Pro Pro Pro Gln Pro Ala Ile Gly Asp Gln Leu 
1               5                   10                  15      


Val Pro Gly Val Pro Gly Pro Ser Ser Glu Ala Glu Asp Asp Pro Gly 
            20                  25                  30          


Glu Ala Phe Glu Phe Asp Asp Ser Asp Asp Glu Glu Asp Thr Ser Ala 
        35                  40                  45              


Ala Leu Gly Val Pro Ser Leu Ala Pro Glu Arg Asp Thr Asp Pro Pro 
    50                  55                  60                  


Leu Ile His Leu Asp Ser Ile Pro Val Thr Asp Pro Asp Pro Ala Ala 
65                  70                  75                  80  


Ala Pro Pro Gly Thr Gly Val Pro Ala Trp Val Ser Asn Gly Asp Ala 
                85                  90                  95      


Ala Asp Ala Ala Phe Ser Gly Ala Arg His Ser Ser Trp Lys Arg Lys 
            100                 105                 110         


Ser Ser Arg Arg Ile Asp Arg Phe Thr Phe Pro Ala Leu Glu Glu Asp 
        115                 120                 125             


Val Ile Tyr Asp Asp Val Pro Cys Glu Ser Pro Asp Ala His Gln Pro 
    130                 135                 140                 


Gly Ala Glu Arg Asn Leu Leu Tyr Glu Asp Ala His Arg Ala Gly Ala 
145                 150                 155                 160 


Pro Arg Gln Ala Glu Asp Leu Gly Trp Ser Ser Ser Glu Phe Glu Ser 
                165                 170                 175     


Tyr Ser Glu Asp Ser Gly Glu Glu Ala Lys Pro Glu Val Glu Val Glu 
            180                 185                 190         


Pro Ala Lys His Arg Val Ser Phe Gln Pro Lys Met Thr Gln Leu Met 
        195                 200                 205             


Lys Ala Ala Lys Ser Gly Thr Lys Asp Gly Leu Glu Lys Thr Arg Met 
    210                 215                 220                 


Ala Val Met Arg Lys Val Ser Phe Leu His Arg Lys Asp Val Leu Gly 
225                 230                 235                 240 


Asp Ser Glu Glu Glu Asp Met Gly Leu Leu Glu Val Ser Val Ser Asp 
                245                 250                 255     


Ile Lys Pro Pro Ala Pro Glu Leu Gly Pro Met Pro Glu Gly Leu Ser 
            260                 265                 270         


Pro Gln Gln Val Val Arg Arg His Ile Leu Gly Ser Ile Val Gln Ser 
        275                 280                 285             


Glu Gly Ser Tyr Val Glu Ser Leu Lys Arg Ile Leu Gln Asp Tyr Arg 
    290                 295                 300                 


Asn Pro Leu Met Glu Met Glu Pro Lys Ala Leu Ser Ala Arg Lys Cys 
305                 310                 315                 320 


Gln Val Val Phe Phe Arg Val Lys Glu Ile Leu His Cys His Ser Met 
                325                 330                 335     


Phe Gln Ile Ala Leu Ser Ser Arg Val Ala Glu Trp Asp Ser Thr Glu 
            340                 345                 350         


Lys Ile Gly Asp Leu Phe Val Ala Ser Phe Ser Lys Ser Met Val Leu 
        355                 360                 365             


Asp Val Tyr Ser Asp Tyr Val Asn Asn Phe Thr Ser Ala Met Ser Ile 
    370                 375                 380                 


Ile Lys Lys Ala Cys Leu Thr Lys Pro Ala Phe Leu Glu Phe Leu Lys 
385                 390                 395                 400 


Arg Arg Gln Val Cys Ser Pro Asp Arg Val Thr Leu Tyr Gly Leu Met 
                405                 410                 415     


Val Lys Pro Ile Gln Arg Phe Pro Gln Phe Ile Leu Leu Leu Gln Asp 
            420                 425                 430         


Met Leu Lys Asn Thr Pro Arg Gly His Pro Asp Arg Leu Ser Leu Gln 
        435                 440                 445             


Leu Ala Leu Thr Glu Leu Glu Thr Leu Ala Glu Lys Leu Asn Glu Gln 
    450                 455                 460                 


Lys Arg Leu Ala Asp Gln Val Ala Glu Ile Gln Gln Leu Thr Lys Ser 
465                 470                 475                 480 


Val Ser Asp Arg Ser Ser Leu Asn Lys Leu Leu Thr Ser Gly Gln Arg 
                485                 490                 495     


Gln Leu Leu Leu Cys Glu Thr Leu Thr Glu Thr Val Tyr Gly Asp Arg 
            500                 505                 510         


Gly Gln Leu Ile Lys Ser Lys Glu Arg Arg Val Phe Leu Leu Asn Asp 
        515                 520                 525             


Met Leu Val Cys Ala Asn Ile Asn Phe Lys Gly Gln Leu Glu Ile Ser 
    530                 535                 540                 


Ser Leu Val Pro Leu Gly Pro Lys Tyr Val Val Lys Trp Asn Thr Ala 
545                 550                 555                 560 


Leu Pro Gln Val Gln Val Val Glu Val Gly Gln Asp Gly Gly Thr Tyr 
                565                 570                 575     


Asp Lys Asp Asn Val Leu Ile Gln His Ser Gly Ala Lys Lys Ala Ser 
            580                 585                 590         


Ala Ser Gly Gln Ala Gln Asn Lys Val Tyr Leu Gly Pro Pro Arg Leu 
        595                 600                 605             


Phe Gln Glu Leu Gln Asp Leu Gln Lys Asp Leu Ala Val Val Glu Gln 
    610                 615                 620                 


Ile Thr Leu Leu Ile Ser Thr Leu His Gly Thr Tyr Gln Asn Leu Asn 
625                 630                 635                 640 


Met Thr Val Ala Gln Asp Trp Cys Leu Ala Leu Gln Arg Leu Met Arg 
                645                 650                 655     


Val Lys Glu Glu Glu Ile His Ser Ala Asn Lys Cys Arg Leu Arg Leu 
            660                 665                 670         


Leu Leu Pro Gly Lys Pro Asp Lys Ser Gly Arg Pro Ile Ser Phe Met 
        675                 680                 685             


Val Val Phe Ile Thr Pro Asn Pro Leu Ser Lys Ile Ser Trp Val Asn 
    690                 695                 700                 


Arg Leu His Leu Ala Lys Ile Gly Leu Arg Glu Glu Asn Gln Pro Gly 
705                 710                 715                 720 


Trp Leu Cys Pro Asp Glu Asp Lys Lys Ser Lys Ala Pro Phe Trp Cys 
                725                 730                 735     


Pro Ile Leu Ala Cys Cys Ile Pro Ala Phe Ser Ser Arg Ala Leu Ser 
            740                 745                 750         


Leu Gln Leu Gly Ala Leu Val His Ser Pro Val Asn Cys Pro Leu Leu 
        755                 760                 765             


Gly Phe Ser Ala Val Ser Thr Ser Leu Pro Gln Gly Tyr Leu Trp Val 
    770                 775                 780                 


Gly Gly Gly Gln Glu Gly Ala Gly Gly Gln Val Glu Ile Phe Ser Leu 
785                 790                 795                 800 


Asn Arg Pro Ser Pro Arg Thr Val Lys Ser Phe Pro Leu Ala Ala Pro 
                805                 810                 815     


Val Leu Cys Met Glu Tyr Ile Pro Glu Leu Glu Glu Glu Ala Glu Ser 
            820                 825                 830         


Arg Asp Glu Ser Pro Thr Val Ala Asp Pro Ser Ala Thr Val His Pro 
        835                 840                 845             


Thr Ile Cys Leu Gly Leu Gln Asp Gly Ser Ile Leu Leu Tyr Ser Ser 
    850                 855                 860                 


Val Asp Thr Gly Thr Gln Cys Leu Val Ser Cys Arg Ser Pro Gly Leu 
865                 870                 875                 880 


Gln Pro Val Leu Cys Leu Arg His Ser Pro Phe His Leu Leu Ala Gly 
                885                 890                 895     


Leu Gln Asp Gly Thr Leu Ala Ala Tyr Pro Arg Thr Ser Gly Gly Val 
            900                 905                 910         


Leu Trp Asp Leu Glu Ser Pro Pro Val Cys Leu Thr Val Gly Pro Gly 
        915                 920                 925             


Pro Val Arg Thr Leu Leu Ser Leu Glu Asp Ala Val Trp Ala Ser Cys 
    930                 935                 940                 


Gly Pro Arg Val Thr Val Leu Glu Ala Thr Thr Leu Gln Pro Gln Gln 
945                 950                 955                 960 


Ser Phe Glu Ala His Gln Asp Glu Ala Val Ser Val Thr His Met Val 
                965                 970                 975     


Lys Ala Gly Ser Gly Val Trp Met Ala Phe Ser Ser Gly Thr Ser Ile 
            980                 985                 990         


Arg Leu Phe His Thr Glu Thr Leu  Glu His Leu Gln Glu  Ile Asn Ile 
        995                 1000                 1005             


Ala Thr  Arg Thr Thr Phe Leu  Leu Pro Gly Gln Lys  His Leu Cys 
    1010                 1015                 1020             


Val Thr  Ser Leu Leu Ile Cys  Gln Gly Leu Leu Trp  Val Gly Thr 
    1025                 1030                 1035             


Asp Gln  Gly Val Ile Val Leu  Leu Pro Val Pro Arg  Leu Glu Gly 
    1040                 1045                 1050             


Ile Pro  Lys Ile Thr Gly Lys  Gly Met Val Ser Leu  Asn Gly His 
    1055                 1060                 1065             


Cys Gly  Pro Val Ala Phe Leu  Ala Val Ala Thr Ser  Ile Leu Ala 
    1070                 1075                 1080             


Pro Asp  Ile Leu Arg Ser Asp  Gln Glu Glu Ala Glu  Gly Pro Arg 
    1085                 1090                 1095             


Ala Glu  Glu Asp Lys Pro Asp  Gly Gln Ala His Glu  Pro Met Pro 
    1100                 1105                 1110             


Asp Ser  His Val Gly Arg Glu  Leu Thr Arg Lys Lys  Gly Ile Leu 
    1115                 1120                 1125             


Leu Gln  Tyr Arg Leu Arg Ser  Thr Ala His Leu Pro  Gly Pro Leu 
    1130                 1135                 1140             


Leu Ser  Met Arg Glu Pro Ala  Pro Ala Asp Gly Ala  Ala Leu Glu 
    1145                 1150                 1155             


His Ser  Glu Glu Asp Gly Ser  Ile Tyr Glu Met Ala  Asp Asp Pro 
    1160                 1165                 1170             


Asp Ile  Trp Val Arg Ser Arg  Pro Cys Ala Arg Asp  Ala His Arg 
    1175                 1180                 1185             


Lys Glu  Ile Cys Ser Val Ala  Ile Ile Ser Gly Gly  Gln Gly Tyr 
    1190                 1195                 1200             


Arg Asn  Phe Gly Ser Ala Leu  Gly Ser Ser Gly Arg  Gln Ala Pro 
    1205                 1210                 1215             


Cys Gly  Glu Thr Asp Ser Thr  Leu Leu Ile Trp Gln  Val Pro Leu 
    1220                 1225                 1230             


Met Leu  
    1235 


<210>  193
<211>  982
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Leu Pro Ser Ser Ser Trp Gly Lys Arg Lys Leu Arg Gly Arg Leu 
1               5                   10                  15      


Gly Trp Val Arg Ser Asp Ala Arg Gly Val Met Trp Ala Arg Gln Glu 
            20                  25                  30          


Gly Leu His His Pro His Pro His Ala Val Ile Arg Cys Pro Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Val Ser Cys Ser Gly Asp Ser Glu Glu Glu Asp Met 
    50                  55                  60                  


Gly Leu Leu Glu Val Ser Val Ser Asp Ile Lys Pro Pro Ala Pro Glu 
65                  70                  75                  80  


Leu Gly Pro Met Pro Glu Gly Leu Ser Pro Gln Gln Val Val Arg Arg 
                85                  90                  95      


His Ile Leu Gly Ser Ile Val Gln Ser Glu Gly Ser Tyr Val Glu Ser 
            100                 105                 110         


Leu Lys Arg Ile Leu Gln Asp Tyr Arg Asn Pro Leu Met Glu Met Glu 
        115                 120                 125             


Pro Lys Ala Leu Ser Ala Arg Lys Cys Gln Val Val Phe Phe Arg Val 
    130                 135                 140                 


Lys Glu Ile Leu His Cys His Ser Met Phe Gln Ile Ala Leu Ser Ser 
145                 150                 155                 160 


Arg Val Ala Glu Trp Asp Ser Thr Glu Lys Ile Gly Asp Leu Phe Val 
                165                 170                 175     


Ala Ser Asp Met Leu Lys Asn Thr Pro Arg Gly His Pro Asp Arg Leu 
            180                 185                 190         


Ser Leu Gln Leu Ala Leu Thr Glu Leu Glu Thr Leu Ala Glu Lys Leu 
        195                 200                 205             


Asn Glu Gln Lys Arg Leu Ala Asp Gln Val Ala Glu Ile Gln Gln Leu 
    210                 215                 220                 


Thr Lys Ser Val Ser Asp Arg Ser Ser Leu Asn Lys Leu Leu Thr Ser 
225                 230                 235                 240 


Gly Gln Arg Gln Leu Leu Leu Cys Glu Thr Leu Thr Glu Thr Val Tyr 
                245                 250                 255     


Gly Asp Arg Gly Gln Leu Ile Lys Ser Lys Glu Arg Arg Val Phe Leu 
            260                 265                 270         


Leu Asn Asp Met Leu Val Cys Ala Asn Ile Asn Phe Lys Gly Gln Leu 
        275                 280                 285             


Glu Ile Ser Ser Leu Val Pro Leu Gly Pro Lys Tyr Val Val Lys Trp 
    290                 295                 300                 


Asn Thr Ala Leu Pro Gln Val Gln Val Val Glu Val Gly Gln Asp Gly 
305                 310                 315                 320 


Gly Thr Tyr Asp Lys Asp Asn Val Leu Ile Gln His Ser Gly Ala Lys 
                325                 330                 335     


Lys Ala Ser Ala Ser Gly Gln Ala Gln Asn Lys Val Tyr Leu Gly Pro 
            340                 345                 350         


Pro Arg Leu Phe Gln Glu Leu Gln Asp Leu Gln Lys Asp Leu Ala Val 
        355                 360                 365             


Val Glu Gln Ile Thr Leu Leu Ile Ser Thr Leu His Gly Thr Tyr Gln 
    370                 375                 380                 


Asn Leu Asn Met Thr Val Ala Gln Asp Trp Cys Leu Ala Leu Gln Arg 
385                 390                 395                 400 


Leu Met Arg Val Lys Glu Glu Glu Ile His Ser Ala Asn Lys Cys Arg 
                405                 410                 415     


Leu Arg Leu Leu Leu Pro Gly Lys Pro Asp Lys Ser Gly Arg Pro Ile 
            420                 425                 430         


Ser Phe Met Val Val Phe Ile Thr Pro Asn Pro Leu Ser Lys Ile Ser 
        435                 440                 445             


Trp Val Asn Arg Leu His Leu Ala Lys Ile Gly Leu Arg Glu Glu Asn 
    450                 455                 460                 


Gln Pro Gly Trp Leu Cys Pro Asp Glu Asp Lys Lys Ser Lys Ala Pro 
465                 470                 475                 480 


Phe Trp Cys Pro Ile Leu Ala Cys Cys Ile Pro Ala Phe Ser Ser Arg 
                485                 490                 495     


Ala Leu Ser Leu Gln Leu Gly Ala Leu Val His Ser Pro Val Asn Cys 
            500                 505                 510         


Pro Leu Leu Gly Phe Ser Ala Val Ser Thr Ser Leu Pro Gln Gly Tyr 
        515                 520                 525             


Leu Trp Val Gly Gly Gly Gln Glu Gly Ala Gly Gly Gln Val Glu Ile 
    530                 535                 540                 


Phe Ser Leu Asn Arg Pro Ser Pro Arg Thr Val Lys Ser Phe Pro Leu 
545                 550                 555                 560 


Ala Ala Pro Val Leu Cys Met Glu Tyr Ile Pro Glu Leu Glu Glu Glu 
                565                 570                 575     


Ala Glu Ser Arg Asp Glu Ser Pro Thr Val Ala Asp Pro Ser Ala Thr 
            580                 585                 590         


Val His Pro Thr Ile Cys Leu Gly Leu Gln Asp Gly Ser Ile Leu Leu 
        595                 600                 605             


Tyr Ser Ser Val Asp Thr Gly Thr Gln Cys Leu Val Ser Cys Arg Ser 
    610                 615                 620                 


Pro Gly Leu Gln Pro Val Leu Cys Leu Arg His Ser Pro Phe His Leu 
625                 630                 635                 640 


Leu Ala Gly Leu Gln Asp Gly Thr Leu Ala Ala Tyr Pro Arg Thr Ser 
                645                 650                 655     


Gly Gly Val Leu Trp Asp Leu Glu Ser Pro Pro Val Cys Leu Thr Val 
            660                 665                 670         


Gly Pro Gly Pro Val Arg Thr Leu Leu Ser Leu Glu Asp Ala Val Trp 
        675                 680                 685             


Ala Ser Cys Gly Pro Arg Val Thr Val Leu Glu Ala Thr Thr Leu Gln 
    690                 695                 700                 


Pro Gln Gln Ser Phe Glu Ala His Gln Asp Glu Ala Val Ser Val Thr 
705                 710                 715                 720 


His Met Val Lys Ala Gly Ser Gly Val Trp Met Ala Phe Ser Ser Gly 
                725                 730                 735     


Thr Ser Ile Arg Leu Phe His Thr Glu Thr Leu Glu His Leu Gln Glu 
            740                 745                 750         


Ile Asn Ile Ala Thr Arg Thr Thr Phe Leu Leu Pro Gly Gln Lys His 
        755                 760                 765             


Leu Cys Val Thr Ser Leu Leu Ile Cys Gln Gly Leu Leu Trp Val Gly 
    770                 775                 780                 


Thr Asp Gln Gly Val Ile Val Leu Leu Pro Val Pro Arg Leu Glu Gly 
785                 790                 795                 800 


Ile Pro Lys Ile Thr Gly Lys Gly Met Val Ser Leu Asn Gly His Cys 
                805                 810                 815     


Gly Pro Val Ala Phe Leu Ala Val Ala Thr Ser Ile Leu Ala Pro Asp 
            820                 825                 830         


Ile Leu Arg Ser Asp Gln Glu Glu Ala Glu Gly Pro Arg Ala Glu Glu 
        835                 840                 845             


Asp Lys Pro Asp Gly Gln Ala His Glu Pro Met Pro Asp Ser His Val 
    850                 855                 860                 


Gly Arg Glu Leu Thr Arg Lys Lys Gly Ile Leu Leu Gln Tyr Arg Leu 
865                 870                 875                 880 


Arg Ser Thr Ala His Leu Pro Gly Pro Leu Leu Ser Met Arg Glu Pro 
                885                 890                 895     


Ala Pro Ala Asp Gly Ala Ala Leu Glu His Ser Glu Glu Asp Gly Ser 
            900                 905                 910         


Ile Tyr Glu Met Ala Asp Asp Pro Asp Ile Trp Val Arg Ser Arg Pro 
        915                 920                 925             


Cys Ala Arg Asp Ala His Arg Lys Glu Ile Cys Ser Val Ala Ile Ile 
    930                 935                 940                 


Ser Gly Gly Gln Gly Tyr Arg Asn Phe Gly Ser Ala Leu Gly Ser Ser 
945                 950                 955                 960 


Gly Arg Gln Ala Pro Cys Gly Glu Thr Asp Ser Thr Leu Leu Ile Trp 
                965                 970                 975     


Gln Val Pro Leu Met Leu 
            980         


<210>  194
<211>  1067
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Ala Ser Ser Asn Pro Pro Pro Gln Pro Ala Ile Gly Asp Gln Leu 
1               5                   10                  15      


Val Pro Gly Val Pro Gly Pro Ser Ser Glu Ala Glu Asp Asp Pro Gly 
            20                  25                  30          


Glu Ala Phe Glu Phe Asp Asp Ser Asp Asp Glu Glu Asp Thr Ser Ala 
        35                  40                  45              


Ala Leu Gly Val Pro Ser Leu Ala Pro Glu Arg Asp Thr Asp Pro Pro 
    50                  55                  60                  


Leu Ile His Leu Asp Ser Ile Pro Val Thr Asp Pro Asp Pro Ala Ala 
65                  70                  75                  80  


Ala Pro Pro Gly Thr Gly Val Pro Ala Trp Val Ser Asn Gly Asp Ala 
                85                  90                  95      


Ala Asp Ala Ala Phe Ser Gly Ala Arg His Ser Ser Trp Lys Arg Lys 
            100                 105                 110         


Ser Ser Arg Arg Ile Asp Arg Phe Thr Phe Pro Ala Leu Glu Glu Asp 
        115                 120                 125             


Val Ile Tyr Asp Asp Val Pro Cys Glu Ser Pro Asp Ala His Gln Pro 
    130                 135                 140                 


Gly Ala Glu Arg Asn Leu Leu Tyr Glu Asp Ala His Arg Ala Gly Ala 
145                 150                 155                 160 


Pro Arg Gln Ala Glu Asp Leu Gly Trp Ser Ser Ser Glu Phe Glu Ser 
                165                 170                 175     


Tyr Ser Glu Asp Ser Gly Glu Glu Ala Lys Pro Glu Val Glu Val Glu 
            180                 185                 190         


Pro Ala Lys His Arg Val Ser Phe Gln Pro Lys Leu Ser Pro Asp Leu 
        195                 200                 205             


Thr Arg Leu Lys Glu Arg Tyr Ala Arg Thr Lys Arg Asp Ile Leu Ala 
    210                 215                 220                 


Leu Arg Val Gly Gly Arg Asp Met Gln Glu Leu Lys His Lys Tyr Asp 
225                 230                 235                 240 


Cys Lys Met Thr Gln Leu Met Lys Ala Ala Lys Ser Gly Thr Lys Asp 
                245                 250                 255     


Gly Leu Glu Lys Thr Arg Met Ala Val Met Arg Lys Val Ser Phe Leu 
            260                 265                 270         


His Arg Lys Asp Val Leu Gly Asp Ser Glu Glu Glu Asp Met Gly Leu 
        275                 280                 285             


Leu Glu Val Ser Val Ser Asp Ile Lys Pro Pro Ala Pro Glu Leu Gly 
    290                 295                 300                 


Pro Met Pro Glu Gly Leu Ser Pro Gln Gln Val Val Arg Arg His Ile 
305                 310                 315                 320 


Leu Gly Ser Ile Val Gln Ser Glu Gly Ser Tyr Val Glu Ser Leu Lys 
                325                 330                 335     


Arg Ile Leu Gln Asp Tyr Arg Asn Pro Leu Met Glu Met Glu Pro Lys 
            340                 345                 350         


Ala Leu Ser Ala Arg Lys Cys Gln Val Val Phe Phe Arg Val Lys Glu 
        355                 360                 365             


Ile Leu His Cys His Ser Met Phe Gln Ile Ala Leu Ser Ser Arg Val 
    370                 375                 380                 


Ala Glu Trp Asp Ser Thr Glu Lys Ile Gly Asp Leu Phe Val Ala Ser 
385                 390                 395                 400 


Phe Ser Lys Ser Met Val Leu Asp Val Tyr Ser Asp Tyr Val Asn Asn 
                405                 410                 415     


Phe Thr Ser Ala Met Ser Ile Ile Lys Lys Ala Cys Leu Thr Lys Pro 
            420                 425                 430         


Ala Phe Leu Glu Phe Leu Lys Arg Arg Gln Val Cys Ser Pro Asp Arg 
        435                 440                 445             


Val Thr Leu Tyr Gly Leu Met Val Lys Pro Ile Gln Arg Phe Pro Gln 
    450                 455                 460                 


Phe Ile Leu Leu Leu Gln Asp Met Leu Lys Asn Thr Pro Arg Gly His 
465                 470                 475                 480 


Pro Asp Arg Leu Ser Leu Gln Leu Ala Leu Thr Glu Leu Glu Thr Leu 
                485                 490                 495     


Ala Glu Lys Leu Asn Glu Gln Lys Arg Leu Ala Asp Gln Val Ala Glu 
            500                 505                 510         


Ile Gln Gln Leu Thr Lys Ser Val Ser Asp Arg Ser Ser Leu Asn Lys 
        515                 520                 525             


Leu Leu Thr Ser Gly Gln Arg Gln Leu Leu Leu Cys Glu Thr Leu Thr 
    530                 535                 540                 


Glu Thr Val Tyr Gly Asp Arg Gly Gln Leu Ile Lys Ser Lys Glu Arg 
545                 550                 555                 560 


Arg Val Phe Leu Leu Asn Asp Met Leu Val Cys Ala Asn Ile Asn Phe 
                565                 570                 575     


Lys Gly Gln Leu Glu Ile Ser Ser Leu Val Pro Leu Gly Pro Lys Tyr 
            580                 585                 590         


Val Val Lys Trp Asn Thr Ala Leu Pro Gln Val Gln Val Val Glu Val 
        595                 600                 605             


Gly Gln Asp Gly Gly Thr Tyr Asp Lys Asp Asn Val Leu Ile Gln His 
    610                 615                 620                 


Ser Gly Ala Lys Lys Ala Ser Ala Ser Gly Gln Ala Gln Asn Lys Val 
625                 630                 635                 640 


Tyr Leu Gly Pro Pro Arg Leu Phe Gln Glu Leu Gln Asp Leu Gln Lys 
                645                 650                 655     


Asp Leu Ala Val Val Glu Gln Ile Thr Leu Leu Ile Ser Thr Leu His 
            660                 665                 670         


Gly Thr Tyr Gln Asn Leu Asn Met Thr Val Ala Gln Asp Trp Cys Leu 
        675                 680                 685             


Ala Leu Gln Arg Leu Met Arg Val Lys Glu Glu Glu Ile His Ser Ala 
    690                 695                 700                 


Asn Lys Cys Arg Leu Arg Leu Leu Leu Pro Gly Lys Pro Asp Lys Ser 
705                 710                 715                 720 


Gly Arg Pro Ile Ser Phe Met Val Val Phe Ile Thr Pro Asn Pro Leu 
                725                 730                 735     


Ser Lys Ile Ser Trp Val Asn Arg Leu His Leu Ala Lys Ile Gly Leu 
            740                 745                 750         


Arg Glu Glu Asn Gln Pro Gly Trp Leu Cys Pro Asp Glu Asp Lys Lys 
        755                 760                 765             


Ser Lys Ala Pro Phe Trp Cys Pro Ile Leu Ala Cys Cys Ile Pro Ala 
    770                 775                 780                 


Phe Ser Ser Arg Ala Leu Ser Leu Gln Leu Gly Ala Leu Val His Ser 
785                 790                 795                 800 


Pro Val Asn Cys Pro Leu Leu Gly Phe Ser Ala Val Ser Thr Ser Leu 
                805                 810                 815     


Pro Gln Gly Tyr Leu Trp Val Gly Gly Gly Gln Glu Gly Ala Gly Gly 
            820                 825                 830         


Gln Val Glu Ile Phe Ser Leu Asn Arg Pro Ser Pro Arg Thr Val Lys 
        835                 840                 845             


Ser Phe Pro Leu Ala Ala Pro Val Leu Cys Met Glu Tyr Ile Pro Glu 
    850                 855                 860                 


Leu Glu Glu Glu Ala Glu Ser Arg Asp Glu Ser Pro Thr Val Ala Asp 
865                 870                 875                 880 


Pro Ser Ala Thr Val His Pro Thr Ile Cys Leu Gly Leu Gln Asp Gly 
                885                 890                 895     


Ser Ile Leu Leu Tyr Ser Ser Val Asp Thr Gly Thr Gln Cys Leu Val 
            900                 905                 910         


Ser Cys Arg Ser Pro Gly Leu Gln Pro Val Leu Cys Leu Arg His Ser 
        915                 920                 925             


Pro Phe His Leu Leu Ala Gly Leu Gln Asp Gly Thr Leu Ala Ala Tyr 
    930                 935                 940                 


Pro Arg Thr Ser Gly Gly Val Leu Trp Asp Leu Glu Ser Pro Pro Val 
945                 950                 955                 960 


Cys Leu Thr Val Gly Pro Gly Pro Val Arg Thr Leu Leu Ser Leu Glu 
                965                 970                 975     


Asp Ala Val Trp Ala Ser Cys Gly Pro Arg Val Thr Val Leu Glu Ala 
            980                 985                 990         


Thr Thr Leu Gln Pro Gln Gln Ser  Phe Glu Ala His Gln  Asp Glu Ala 
        995                 1000                 1005             


Val Ser  Val Thr His Met Val  Lys Ala Gly Ser Gly  Val Trp Met 
    1010                 1015                 1020             


Ala Phe  Ser Ser Gly Thr Ser  Ile Arg Leu Phe His  Thr Glu Thr 
    1025                 1030                 1035             


Leu Glu  His Leu Gln Glu Ile  Asn Ile Ala Thr Arg  Thr Thr Phe 
    1040                 1045                 1050             


Leu Leu  Pro Asp Arg Ser Leu  Ile Lys Cys Ser Pro  Arg Ala 
    1055                 1060                 1065         


<210>  195
<211>  973
<212>  PRT
<213>  Homo sapiens

<400>  195

Met Tyr Asn Met Arg Arg Leu Ser Leu Ser Pro Thr Phe Ser Met Gly 
1               5                   10                  15      


Phe His Leu Leu Val Thr Val Ser Leu Leu Phe Ser His Val Asp His 
            20                  25                  30          


Val Ile Ala Glu Thr Glu Met Glu Gly Glu Gly Asn Glu Thr Gly Glu 
        35                  40                  45              


Cys Thr Gly Ser Tyr Tyr Cys Lys Lys Gly Val Ile Leu Pro Ile Trp 
    50                  55                  60                  


Glu Pro Gln Asp Pro Ser Phe Gly Asp Lys Ile Ala Arg Ala Thr Val 
65                  70                  75                  80  


Tyr Phe Val Ala Met Val Tyr Met Phe Leu Gly Val Ser Ile Ile Ala 
                85                  90                  95      


Asp Arg Phe Met Ser Ser Ile Glu Val Ile Thr Ser Gln Glu Lys Glu 
            100                 105                 110         


Ile Thr Ile Lys Lys Pro Asn Gly Glu Thr Thr Lys Thr Thr Val Arg 
        115                 120                 125             


Ile Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser 
    130                 135                 140                 


Ser Ala Pro Glu Ile Leu Leu Ser Val Ile Glu Val Cys Gly His Asn 
145                 150                 155                 160 


Phe Thr Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala 
                165                 170                 175     


Phe Asn Met Phe Ile Ile Ile Ala Leu Cys Val Tyr Val Val Pro Asp 
            180                 185                 190         


Gly Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Val Thr Ala 
        195                 200                 205             


Ala Trp Ser Ile Phe Ala Tyr Thr Trp Leu Tyr Ile Ile Leu Ser Val 
    210                 215                 220                 


Ile Ser Pro Gly Val Val Glu Val Trp Glu Gly Leu Leu Thr Phe Phe 
225                 230                 235                 240 


Phe Phe Pro Ile Cys Val Val Phe Ala Trp Val Ala Asp Arg Arg Leu 
                245                 250                 255     


Leu Phe Tyr Lys Tyr Val Tyr Lys Arg Tyr Arg Ala Gly Lys Gln Arg 
            260                 265                 270         


Gly Met Ile Ile Glu His Glu Gly Asp Arg Pro Ser Ser Lys Thr Glu 
        275                 280                 285             


Ile Glu Met Asp Gly Lys Val Val Asn Ser His Val Glu Asn Phe Leu 
    290                 295                 300                 


Asp Gly Ala Leu Val Leu Glu Val Asp Glu Arg Asp Gln Asp Asp Glu 
305                 310                 315                 320 


Glu Ala Arg Arg Glu Met Ala Arg Ile Leu Lys Glu Leu Lys Gln Lys 
                325                 330                 335     


His Pro Asp Lys Glu Ile Glu Gln Leu Ile Glu Leu Ala Asn Tyr Gln 
            340                 345                 350         


Val Leu Ser Gln Gln Gln Lys Ser Arg Ala Phe Tyr Arg Ile Gln Ala 
        355                 360                 365             


Thr Arg Leu Met Thr Gly Ala Gly Asn Ile Leu Lys Arg His Ala Ala 
    370                 375                 380                 


Asp Gln Ala Arg Lys Ala Val Ser Met His Glu Val Asn Thr Glu Val 
385                 390                 395                 400 


Thr Glu Asn Asp Pro Val Ser Lys Ile Phe Phe Glu Gln Gly Thr Tyr 
                405                 410                 415     


Gln Cys Leu Glu Asn Cys Gly Thr Val Ala Leu Thr Ile Ile Arg Arg 
            420                 425                 430         


Gly Gly Asp Leu Thr Asn Thr Val Phe Val Asp Phe Arg Thr Glu Asp 
        435                 440                 445             


Gly Thr Ala Asn Ala Gly Ser Asp Tyr Glu Phe Thr Glu Gly Thr Val 
    450                 455                 460                 


Val Phe Lys Pro Gly Asp Thr Gln Lys Glu Ile Arg Val Gly Ile Ile 
465                 470                 475                 480 


Asp Asp Asp Ile Phe Glu Glu Asp Glu Asn Phe Leu Val His Leu Ser 
                485                 490                 495     


Asn Val Lys Val Ser Ser Glu Ala Ser Glu Asp Gly Ile Leu Glu Ala 
            500                 505                 510         


Asn His Val Ser Thr Leu Ala Cys Leu Gly Ser Pro Ser Thr Ala Thr 
        515                 520                 525             


Val Thr Ile Phe Asp Asp Asp His Ala Gly Ile Phe Thr Phe Glu Glu 
    530                 535                 540                 


Pro Val Thr His Val Ser Glu Ser Ile Gly Ile Met Glu Val Lys Val 
545                 550                 555                 560 


Leu Arg Thr Ser Gly Ala Arg Gly Asn Val Ile Val Pro Tyr Lys Thr 
                565                 570                 575     


Ile Glu Gly Thr Ala Arg Gly Gly Gly Glu Asp Phe Glu Asp Thr Cys 
            580                 585                 590         


Gly Glu Leu Glu Phe Gln Asn Asp Glu Ile Val Lys Thr Ile Ser Val 
        595                 600                 605             


Lys Val Ile Asp Asp Glu Glu Tyr Glu Lys Asn Lys Thr Phe Phe Leu 
    610                 615                 620                 


Glu Ile Gly Glu Pro Arg Leu Val Glu Met Ser Glu Lys Lys Ala Leu 
625                 630                 635                 640 


Leu Leu Asn Glu Leu Gly Gly Phe Thr Ile Thr Gly Lys Tyr Leu Phe 
                645                 650                 655     


Gly Gln Pro Val Phe Arg Lys Val His Ala Arg Glu His Pro Ile Leu 
            660                 665                 670         


Ser Thr Val Ile Thr Ile Ala Asp Glu Tyr Asp Asp Lys Gln Pro Leu 
        675                 680                 685             


Thr Ser Lys Glu Glu Glu Glu Arg Arg Ile Ala Glu Met Gly Arg Pro 
    690                 695                 700                 


Ile Leu Gly Glu His Thr Lys Leu Glu Val Ile Ile Glu Glu Ser Tyr 
705                 710                 715                 720 


Glu Phe Lys Ser Thr Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala 
                725                 730                 735     


Leu Val Val Gly Thr Asn Ser Trp Arg Glu Gln Phe Ile Glu Ala Ile 
            740                 745                 750         


Thr Val Ser Ala Gly Glu Asp Asp Asp Asp Asp Glu Cys Gly Glu Glu 
        755                 760                 765             


Lys Leu Pro Ser Cys Phe Asp Tyr Val Met His Phe Leu Thr Val Phe 
    770                 775                 780                 


Trp Lys Val Leu Phe Ala Phe Val Pro Pro Thr Glu Tyr Trp Asn Gly 
785                 790                 795                 800 


Trp Ala Cys Phe Ile Val Ser Ile Leu Met Ile Gly Leu Leu Thr Ala 
                805                 810                 815     


Phe Ile Gly Asp Leu Ala Ser His Phe Gly Cys Thr Ile Gly Leu Lys 
            820                 825                 830         


Asp Ser Val Thr Ala Val Val Phe Val Ala Leu Gly Thr Ser Val Pro 
        835                 840                 845             


Asp Thr Phe Ala Ser Lys Val Ala Ala Thr Gln Asp Gln Tyr Ala Asp 
    850                 855                 860                 


Ala Ser Ile Gly Asn Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu 
865                 870                 875                 880 


Gly Ile Gly Val Ala Trp Ser Ile Ala Ala Ile Tyr His Ala Ala Asn 
                885                 890                 895     


Gly Glu Gln Phe Lys Val Ser Pro Gly Thr Leu Ala Phe Ser Val Thr 
            900                 905                 910         


Leu Phe Thr Ile Phe Ala Phe Ile Asn Val Gly Val Leu Leu Tyr Arg 
        915                 920                 925             


Arg Arg Pro Glu Ile Gly Gly Glu Leu Gly Gly Pro Arg Thr Ala Lys 
    930                 935                 940                 


Leu Leu Thr Ser Cys Leu Phe Val Leu Leu Trp Leu Leu Tyr Ile Phe 
945                 950                 955                 960 


Phe Ser Ser Leu Glu Ala Tyr Cys His Ile Lys Gly Phe 
                965                 970             


<210>  196
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Tyr Asn Met Arg Arg Leu Ser Leu Ser Pro Thr Phe Ser Met Gly 
1               5                   10                  15      


Phe His Leu Leu Val Thr Val Ser Leu Leu Phe Ser His Val Asp His 
            20                  25                  30          


Val Ile Ala Glu Thr Glu Met Glu Gly Glu Gly Asn Glu Thr Gly Glu 
        35                  40                  45              


Cys Thr Gly Ser Tyr Tyr Cys Lys Lys Gly Val Ile Leu Pro Ile Trp 
    50                  55                  60                  


Glu Pro Gln Asp Pro Ser Phe Gly Asp Lys Ile Ala Arg Ala Thr Val 
65                  70                  75                  80  


Tyr Phe Val Ala Met Val Tyr Met Phe Leu Gly Val Ser Ile Ile Ala 
                85                  90                  95      


Asp Arg Phe Met Ser Ser Ile Glu Val Ile Thr Ser Gln Glu Lys Glu 
            100                 105                 110         


Ile Thr Ile Lys Lys Pro Asn Gly Glu Thr Thr Lys Thr Thr Val Arg 
        115                 120                 125             


Ile Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser 
    130                 135                 140                 


Ser Ala Pro Glu Ile Leu Leu Ser Val Ile Glu Val Cys Gly His Asn 
145                 150                 155                 160 


Phe Thr Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala 
                165                 170                 175     


Phe Asn Met Phe Ile Ile Ile Ala Leu Cys Val Tyr Val Val Pro Asp 
            180                 185                 190         


Gly Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Val Thr Ala 
        195                 200                 205             


Ala Trp Ser Ile Phe Ala Tyr Thr Trp Leu Tyr Ile Ile Leu Ser Val 
    210                 215                 220                 


Ile Ser Pro Gly Val Val Glu Val Trp Glu Gly Leu Leu Thr Phe Phe 
225                 230                 235                 240 


Phe Phe Pro Ile Cys Val Val Phe Ala Trp Val Ala Asp Arg Arg Leu 
                245                 250                 255     


Leu Phe Tyr Lys Tyr Val Tyr Lys Arg Tyr Arg Ala Gly Lys Gln Arg 
            260                 265                 270         


Gly Met Ile Ile Glu His Glu Gly Asp Arg Pro Ser Ser Lys Thr Glu 
        275                 280                 285             


Ile Glu Met Asp Gly Lys Val Val Asn Ser His Val Glu Asn Phe Leu 
    290                 295                 300                 


Asp Gly Ala Leu Val Leu Glu Val Asp Glu Arg Asp Gln Asp Asp Glu 
305                 310                 315                 320 


Glu Ala Arg Arg Glu Met Ala Arg Ile Leu Lys Glu Leu Lys Gln Lys 
                325                 330                 335     


His Pro Asp Lys Glu Ile Glu Gln Leu Ile Glu Leu Ala Asn Tyr Gln 
            340                 345                 350         


Val Leu Ser Gln Gln Gln Lys Ser Arg Ala Phe Tyr Arg Ile Gln Ala 
        355                 360                 365             


Thr Arg Leu Met Thr Gly Ala Gly Asn Ile Leu Lys Arg His Ala Ala 
    370                 375                 380                 


Asp Gln Ala Arg Lys Ala Val Ser Met His Glu Val Asn Thr Glu Val 
385                 390                 395                 400 


Thr Glu Asn Asp Pro Val Ser Lys Ile Phe Phe Glu Gln Gly Thr Tyr 
                405                 410                 415     


Gln Cys Leu Glu Asn Cys Gly Thr Val Ala Leu Thr Ile Ile Arg Arg 
            420                 425                 430         


Gly Gly Asp Leu Thr Asn Thr Val Phe Val Asp Phe Arg Thr Glu Asp 
        435                 440                 445             


Gly Thr Ala Asn Ala Gly Ser Asp Tyr Glu Phe Thr Glu Gly Thr Val 
    450                 455                 460                 


Val Phe Lys Pro Gly Asp Thr Gln Lys Glu Ile Arg Val Gly Ile Ile 
465                 470                 475                 480 


Asp Asp Asp Ile Phe Glu Glu Asp Glu Asn Phe Leu Val His Leu Ser 
                485                 490                 495     


Asn Val Lys Val Ser Ser Glu Ala Ser Glu Asp Gly Ile Leu Glu Ala 
            500                 505                 510         


Asn His Val Ser Thr Leu Ala Cys Leu Gly Ser Pro Ser Thr Ala Thr 
        515                 520                 525             


Val Thr Ile Phe Asp Asp Asp His Ala Gly Ile Phe Thr Phe Glu Glu 
    530                 535                 540                 


Pro Val Thr His Val Ser Glu Ser Ile Gly Ile Met Glu Val Lys Val 
545                 550                 555                 560 


Leu Arg Thr Ser Gly Ala Arg Gly Asn Val Ile Val Pro Tyr Lys Thr 
                565                 570                 575     


Ile Glu Gly Thr Ala Arg Gly Gly Gly Glu Asp Phe Glu Asp Thr Cys 
            580                 585                 590         


Gly Glu Leu Glu Phe Gln Asn Asp Glu Ile Val Lys Ile Ile Thr Ile 
        595                 600                 605             


Arg Ile Phe Asp Arg Glu Glu Tyr Glu Lys Glu Cys Ser Phe Ser Leu 
    610                 615                 620                 


Val Leu Glu Glu Pro Lys Trp Ile Arg Arg Gly Met Lys Gly Gly Phe 
625                 630                 635                 640 


Thr Ile Thr Asp Glu Tyr Asp Asp Lys Gln Pro Leu Thr Ser Lys Glu 
                645                 650                 655     


Glu Glu Glu Arg Arg Ile Ala Glu Met Gly Arg Pro Ile Leu Gly Glu 
            660                 665                 670         


His Thr Lys Leu Glu Val Ile Ile Glu Glu Ser Tyr Glu Phe Lys Ser 
        675                 680                 685             


Thr Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala Leu Val Val Gly 
    690                 695                 700                 


Thr Asn Ser Trp Arg Glu Gln Phe Ile Glu Ala Ile Thr Val Ser Ala 
705                 710                 715                 720 


Gly Glu Asp Asp Asp Asp Asp Glu Cys Gly Glu Glu Lys Leu Pro Ser 
                725                 730                 735     


Cys Phe Asp Tyr Val Met His Phe Leu Thr Val Phe Trp Lys Val Leu 
            740                 745                 750         


Phe Ala Phe Val Pro Pro Thr Glu Tyr Trp Asn Gly Trp Ala Cys Phe 
        755                 760                 765             


Ile Val Ser Ile Leu Met Ile Gly Leu Leu Thr Ala Phe Ile Gly Asp 
    770                 775                 780                 


Leu Ala Ser His Phe Gly Cys Thr Ile Gly Leu Lys Asp Ser Val Thr 
785                 790                 795                 800 


Ala Val Val Phe Val Ala Leu Gly Thr Ser Val Pro Asp Thr Phe Ala 
                805                 810                 815     


Ser Lys Val Ala Ala Thr Gln Asp Gln Tyr Ala Asp Ala Ser Ile Gly 
            820                 825                 830         


Asn Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu Gly Ile Gly Val 
        835                 840                 845             


Ala Trp Ser Ile Ala Ala Ile Tyr His Ala Ala Asn Gly Glu Gln Phe 
    850                 855                 860                 


Lys Val Ser Pro Gly Thr Leu Ala Phe Ser Val Thr Leu Phe Thr Ile 
865                 870                 875                 880 


Phe Ala Phe Ile Asn Val Gly Val Leu Leu Tyr Arg Arg Arg Pro Glu 
                885                 890                 895     


Ile Gly Gly Glu Leu Gly Gly Pro Arg Thr Ala Lys Leu Leu Thr Ser 
            900                 905                 910         


Cys Leu Phe Val Leu Leu Trp Leu Leu Tyr Ile Phe Phe Ser Ser Leu 
        915                 920                 925             


Glu Ala Tyr Cys His Ile Lys Gly Phe 
    930                 935         


<210>  197
<211>  960
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Tyr Asn Met Arg Arg Leu Ser Leu Ser Pro Thr Phe Ser Met Gly 
1               5                   10                  15      


Phe His Leu Leu Val Thr Val Ser Leu Leu Phe Ser His Val Asp His 
            20                  25                  30          


Val Ile Ala Glu Thr Glu Met Glu Gly Glu Gly Asn Glu Thr Gly Glu 
        35                  40                  45              


Cys Thr Gly Ser Tyr Tyr Cys Lys Lys Gly Val Ile Leu Pro Ile Trp 
    50                  55                  60                  


Glu Pro Gln Asp Pro Ser Phe Gly Asp Lys Ile Ala Arg Ala Thr Val 
65                  70                  75                  80  


Tyr Phe Val Ala Met Val Tyr Met Phe Leu Gly Val Ser Ile Ile Ala 
                85                  90                  95      


Asp Arg Phe Met Ser Ser Ile Glu Val Ile Thr Ser Gln Glu Lys Glu 
            100                 105                 110         


Ile Thr Ile Lys Lys Pro Asn Gly Glu Thr Thr Lys Thr Thr Val Arg 
        115                 120                 125             


Ile Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser 
    130                 135                 140                 


Ser Ala Pro Glu Ile Leu Leu Ser Val Ile Glu Val Cys Gly His Asn 
145                 150                 155                 160 


Phe Thr Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala 
                165                 170                 175     


Phe Asn Met Phe Ile Ile Ile Ala Leu Cys Val Tyr Val Val Pro Asp 
            180                 185                 190         


Gly Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Val Thr Ala 
        195                 200                 205             


Ala Trp Ser Ile Phe Ala Tyr Thr Trp Leu Tyr Ile Ile Leu Ser Val 
    210                 215                 220                 


Ile Ser Pro Gly Val Val Glu Val Trp Glu Gly Leu Leu Thr Phe Phe 
225                 230                 235                 240 


Phe Phe Pro Ile Cys Val Val Phe Ala Trp Val Ala Asp Arg Arg Leu 
                245                 250                 255     


Leu Phe Tyr Lys Tyr Val Tyr Lys Arg Tyr Arg Ala Gly Lys Gln Arg 
            260                 265                 270         


Gly Met Ile Ile Glu His Glu Gly Asp Arg Pro Ser Ser Lys Thr Glu 
        275                 280                 285             


Ile Glu Met Asp Gly Lys Val Val Asn Ser His Val Glu Asn Phe Leu 
    290                 295                 300                 


Asp Gly Ala Leu Val Leu Glu Val Asp Glu Arg Asp Gln Asp Asp Glu 
305                 310                 315                 320 


Glu Ala Arg Arg Glu Met Ala Arg Ile Leu Lys Glu Leu Lys Gln Lys 
                325                 330                 335     


His Pro Asp Lys Glu Ile Glu Gln Leu Ile Glu Leu Ala Asn Tyr Gln 
            340                 345                 350         


Val Leu Ser Gln Gln Gln Lys Ser Arg Ala Phe Tyr Arg Ile Gln Ala 
        355                 360                 365             


Thr Arg Leu Met Thr Gly Ala Gly Asn Ile Leu Lys Arg His Ala Ala 
    370                 375                 380                 


Asp Gln Ala Arg Lys Ala Val Ser Met His Glu Val Asn Thr Glu Val 
385                 390                 395                 400 


Thr Glu Asn Asp Pro Val Ser Lys Ile Phe Phe Glu Gln Gly Thr Tyr 
                405                 410                 415     


Gln Cys Leu Glu Asn Cys Gly Thr Val Ala Leu Thr Ile Ile Arg Arg 
            420                 425                 430         


Gly Gly Asp Leu Thr Asn Thr Val Phe Val Asp Phe Arg Thr Glu Asp 
        435                 440                 445             


Gly Thr Ala Asn Ala Gly Ser Asp Tyr Glu Phe Thr Glu Gly Thr Val 
    450                 455                 460                 


Val Phe Lys Pro Gly Asp Thr Gln Lys Glu Ile Arg Val Gly Ile Ile 
465                 470                 475                 480 


Asp Asp Asp Ile Phe Glu Glu Asp Glu Asn Phe Leu Val His Leu Ser 
                485                 490                 495     


Asn Val Lys Val Ser Ser Glu Ala Ser Glu Asp Gly Ile Leu Glu Ala 
            500                 505                 510         


Asn His Val Ser Thr Leu Ala Cys Leu Gly Ser Pro Ser Thr Ala Thr 
        515                 520                 525             


Val Thr Ile Phe Asp Asp Asp His Ala Gly Ile Phe Thr Phe Glu Glu 
    530                 535                 540                 


Pro Val Thr His Val Ser Glu Ser Ile Gly Ile Met Glu Val Lys Val 
545                 550                 555                 560 


Leu Arg Thr Ser Gly Ala Arg Gly Asn Val Ile Val Pro Tyr Lys Thr 
                565                 570                 575     


Ile Glu Gly Thr Ala Arg Gly Gly Gly Glu Asp Phe Glu Asp Thr Cys 
            580                 585                 590         


Gly Glu Leu Glu Phe Gln Asn Asp Glu Ile Val Lys Ile Ile Thr Ile 
        595                 600                 605             


Arg Ile Phe Asp Arg Glu Glu Tyr Glu Lys Glu Cys Ser Phe Ser Leu 
    610                 615                 620                 


Val Leu Glu Glu Pro Lys Trp Ile Arg Arg Gly Met Lys Gly Gly Phe 
625                 630                 635                 640 


Thr Ile Thr Gly Gln Pro Val Phe Arg Lys Val His Ala Arg Glu His 
                645                 650                 655     


Pro Ile Leu Ser Thr Val Ile Thr Ile Ala Asp Glu Tyr Asp Asp Lys 
            660                 665                 670         


Gln Pro Leu Thr Ser Lys Glu Glu Glu Glu Arg Arg Ile Ala Glu Met 
        675                 680                 685             


Gly Arg Pro Ile Leu Gly Glu His Thr Lys Leu Glu Val Ile Ile Glu 
    690                 695                 700                 


Glu Ser Tyr Glu Phe Lys Ser Thr Val Asp Lys Leu Ile Lys Lys Thr 
705                 710                 715                 720 


Asn Leu Ala Leu Val Val Gly Thr Asn Ser Trp Arg Glu Gln Phe Ile 
                725                 730                 735     


Glu Ala Ile Thr Val Ser Ala Gly Glu Asp Asp Asp Asp Asp Glu Cys 
            740                 745                 750         


Gly Glu Glu Lys Leu Pro Ser Cys Phe Asp Tyr Val Met His Phe Leu 
        755                 760                 765             


Thr Val Phe Trp Lys Val Leu Phe Ala Phe Val Pro Pro Thr Glu Tyr 
    770                 775                 780                 


Trp Asn Gly Trp Ala Cys Phe Ile Val Ser Ile Leu Met Ile Gly Leu 
785                 790                 795                 800 


Leu Thr Ala Phe Ile Gly Asp Leu Ala Ser His Phe Gly Cys Thr Ile 
                805                 810                 815     


Gly Leu Lys Asp Ser Val Thr Ala Val Val Phe Val Ala Leu Gly Thr 
            820                 825                 830         


Ser Val Pro Asp Thr Phe Ala Ser Lys Val Ala Ala Thr Gln Asp Gln 
        835                 840                 845             


Tyr Ala Asp Ala Ser Ile Gly Asn Val Thr Gly Ser Asn Ala Val Asn 
    850                 855                 860                 


Val Phe Leu Gly Ile Gly Val Ala Trp Ser Ile Ala Ala Ile Tyr His 
865                 870                 875                 880 


Ala Ala Asn Gly Glu Gln Phe Lys Val Ser Pro Gly Thr Leu Ala Phe 
                885                 890                 895     


Ser Val Thr Leu Phe Thr Ile Phe Ala Phe Ile Asn Val Gly Val Leu 
            900                 905                 910         


Leu Tyr Arg Arg Arg Pro Glu Ile Gly Gly Glu Leu Gly Gly Pro Arg 
        915                 920                 925             


Thr Ala Lys Leu Leu Thr Ser Cys Leu Phe Val Leu Leu Trp Leu Leu 
    930                 935                 940                 


Tyr Ile Phe Phe Ser Ser Leu Glu Ala Tyr Cys His Ile Lys Gly Phe 
945                 950                 955                 960 


<210>  198
<211>  965
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Tyr Asn Met Arg Arg Leu Ser Leu Ser Pro Thr Phe Ser Met Gly 
1               5                   10                  15      


Phe His Leu Leu Val Thr Val Ser Leu Leu Phe Ser His Val Asp His 
            20                  25                  30          


Val Ile Ala Glu Thr Glu Met Glu Gly Glu Gly Asn Glu Thr Gly Glu 
        35                  40                  45              


Cys Thr Gly Ser Tyr Tyr Cys Lys Lys Gly Val Ile Leu Pro Ile Trp 
    50                  55                  60                  


Glu Pro Gln Asp Pro Ser Phe Gly Asp Lys Ile Ala Arg Ala Thr Val 
65                  70                  75                  80  


Tyr Phe Val Ala Met Val Tyr Met Phe Leu Gly Val Ser Ile Ile Ala 
                85                  90                  95      


Asp Arg Phe Met Ser Ser Ile Glu Val Ile Thr Ser Gln Glu Lys Glu 
            100                 105                 110         


Ile Thr Ile Lys Lys Pro Asn Gly Glu Thr Thr Lys Thr Thr Val Arg 
        115                 120                 125             


Ile Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser 
    130                 135                 140                 


Ser Ala Pro Glu Ile Leu Leu Ser Val Ile Glu Val Cys Gly His Asn 
145                 150                 155                 160 


Phe Thr Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala 
                165                 170                 175     


Phe Asn Met Phe Ile Ile Ile Ala Leu Cys Val Tyr Val Val Pro Asp 
            180                 185                 190         


Gly Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Val Thr Ala 
        195                 200                 205             


Ala Trp Ser Ile Phe Ala Tyr Thr Trp Leu Tyr Ile Ile Leu Ser Val 
    210                 215                 220                 


Ile Ser Pro Gly Val Val Glu Val Trp Glu Gly Leu Leu Thr Phe Phe 
225                 230                 235                 240 


Phe Phe Pro Ile Cys Val Val Phe Ala Trp Val Ala Asp Arg Arg Leu 
                245                 250                 255     


Leu Phe Tyr Lys Tyr Val Tyr Lys Arg Tyr Arg Ala Gly Lys Gln Arg 
            260                 265                 270         


Gly Met Ile Ile Glu His Glu Gly Asp Arg Pro Ser Ser Lys Thr Glu 
        275                 280                 285             


Ile Glu Met Asp Gly Lys Val Val Asn Ser His Val Glu Asn Phe Leu 
    290                 295                 300                 


Asp Gly Ala Leu Val Leu Glu Val Asp Glu Arg Asp Gln Asp Asp Glu 
305                 310                 315                 320 


Glu Ala Arg Arg Glu Met Ala Arg Ile Leu Lys Glu Leu Lys Gln Lys 
                325                 330                 335     


His Pro Asp Lys Glu Ile Glu Gln Leu Ile Glu Leu Ala Asn Tyr Gln 
            340                 345                 350         


Val Leu Ser Gln Gln Gln Lys Ser Arg Ala Phe Tyr Arg Ile Gln Ala 
        355                 360                 365             


Thr Arg Leu Met Thr Gly Ala Gly Asn Ile Leu Lys Arg His Ala Ala 
    370                 375                 380                 


Asp Gln Ala Arg Lys Ala Val Ser Met His Glu Val Asn Thr Glu Val 
385                 390                 395                 400 


Thr Glu Asn Asp Pro Val Ser Lys Ile Phe Phe Glu Gln Gly Thr Tyr 
                405                 410                 415     


Gln Cys Leu Glu Asn Cys Gly Thr Val Ala Leu Thr Ile Ile Arg Arg 
            420                 425                 430         


Gly Gly Asp Leu Thr Asn Thr Val Phe Val Asp Phe Arg Thr Glu Asp 
        435                 440                 445             


Gly Thr Ala Asn Ala Gly Ser Asp Tyr Glu Phe Thr Glu Gly Thr Val 
    450                 455                 460                 


Val Phe Lys Pro Gly Asp Thr Gln Lys Glu Ile Arg Val Gly Ile Ile 
465                 470                 475                 480 


Asp Asp Asp Ile Phe Glu Glu Asp Glu Asn Phe Leu Val His Leu Ser 
                485                 490                 495     


Asn Val Lys Val Ser Ser Glu Ala Ser Glu Asp Gly Ile Leu Glu Ala 
            500                 505                 510         


Asn His Val Ser Thr Leu Ala Cys Leu Gly Ser Pro Ser Thr Ala Thr 
        515                 520                 525             


Val Thr Ile Phe Asp Asp Asp His Ala Gly Ile Phe Thr Phe Glu Glu 
    530                 535                 540                 


Pro Val Thr His Val Ser Glu Ser Ile Gly Ile Met Glu Val Lys Val 
545                 550                 555                 560 


Leu Arg Thr Ser Gly Ala Arg Gly Asn Val Ile Val Pro Tyr Lys Thr 
                565                 570                 575     


Ile Glu Gly Thr Ala Arg Gly Gly Gly Glu Asp Phe Glu Asp Thr Cys 
            580                 585                 590         


Gly Glu Leu Glu Phe Gln Asn Asp Glu Ile Val Lys Ile Ile Thr Ile 
        595                 600                 605             


Arg Ile Phe Asp Arg Glu Glu Tyr Glu Lys Glu Cys Ser Phe Ser Leu 
    610                 615                 620                 


Val Leu Glu Glu Pro Lys Trp Ile Arg Arg Gly Met Lys Gly Gly Phe 
625                 630                 635                 640 


Thr Ile Thr Gly Lys Tyr Leu Phe Gly Gln Pro Val Phe Arg Lys Val 
                645                 650                 655     


His Ala Arg Glu His Pro Ile Leu Ser Thr Val Ile Thr Ile Ala Asp 
            660                 665                 670         


Glu Tyr Asp Asp Lys Gln Pro Leu Thr Ser Lys Glu Glu Glu Glu Arg 
        675                 680                 685             


Arg Ile Ala Glu Met Gly Arg Pro Ile Leu Gly Glu His Thr Lys Leu 
    690                 695                 700                 


Glu Val Ile Ile Glu Glu Ser Tyr Glu Phe Lys Ser Thr Val Asp Lys 
705                 710                 715                 720 


Leu Ile Lys Lys Thr Asn Leu Ala Leu Val Val Gly Thr Asn Ser Trp 
                725                 730                 735     


Arg Glu Gln Phe Ile Glu Ala Ile Thr Val Ser Ala Gly Glu Asp Asp 
            740                 745                 750         


Asp Asp Asp Glu Cys Gly Glu Glu Lys Leu Pro Ser Cys Phe Asp Tyr 
        755                 760                 765             


Val Met His Phe Leu Thr Val Phe Trp Lys Val Leu Phe Ala Phe Val 
    770                 775                 780                 


Pro Pro Thr Glu Tyr Trp Asn Gly Trp Ala Cys Phe Ile Val Ser Ile 
785                 790                 795                 800 


Leu Met Ile Gly Leu Leu Thr Ala Phe Ile Gly Asp Leu Ala Ser His 
                805                 810                 815     


Phe Gly Cys Thr Ile Gly Leu Lys Asp Ser Val Thr Ala Val Val Phe 
            820                 825                 830         


Val Ala Leu Gly Thr Ser Val Pro Asp Thr Phe Ala Ser Lys Val Ala 
        835                 840                 845             


Ala Thr Gln Asp Gln Tyr Ala Asp Ala Ser Ile Gly Asn Val Thr Gly 
    850                 855                 860                 


Ser Asn Ala Val Asn Val Phe Leu Gly Ile Gly Val Ala Trp Ser Ile 
865                 870                 875                 880 


Ala Ala Ile Tyr His Ala Ala Asn Gly Glu Gln Phe Lys Val Ser Pro 
                885                 890                 895     


Gly Thr Leu Ala Phe Ser Val Thr Leu Phe Thr Ile Phe Ala Phe Ile 
            900                 905                 910         


Asn Val Gly Val Leu Leu Tyr Arg Arg Arg Pro Glu Ile Gly Gly Glu 
        915                 920                 925             


Leu Gly Gly Pro Arg Thr Ala Lys Leu Leu Thr Ser Cys Leu Phe Val 
    930                 935                 940                 


Leu Leu Trp Leu Leu Tyr Ile Phe Phe Ser Ser Leu Glu Ala Tyr Cys 
945                 950                 955                 960 


His Ile Lys Gly Phe 
                965 


<210>  199
<211>  968
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Tyr Asn Met Arg Arg Leu Ser Leu Ser Pro Thr Phe Ser Met Gly 
1               5                   10                  15      


Phe His Leu Leu Val Thr Val Ser Leu Leu Phe Ser His Val Asp His 
            20                  25                  30          


Val Ile Ala Glu Thr Glu Met Glu Gly Glu Gly Asn Glu Thr Gly Glu 
        35                  40                  45              


Cys Thr Gly Ser Tyr Tyr Cys Lys Lys Gly Val Ile Leu Pro Ile Trp 
    50                  55                  60                  


Glu Pro Gln Asp Pro Ser Phe Gly Asp Lys Ile Ala Arg Ala Thr Val 
65                  70                  75                  80  


Tyr Phe Val Ala Met Val Tyr Met Phe Leu Gly Val Ser Ile Ile Ala 
                85                  90                  95      


Asp Arg Phe Met Ser Ser Ile Glu Val Ile Thr Ser Gln Glu Lys Glu 
            100                 105                 110         


Ile Thr Ile Lys Lys Pro Asn Gly Glu Thr Thr Lys Thr Thr Val Arg 
        115                 120                 125             


Ile Trp Asn Glu Thr Val Ser Asn Leu Thr Leu Met Ala Leu Gly Ser 
    130                 135                 140                 


Ser Ala Pro Glu Ile Leu Leu Ser Val Ile Glu Val Cys Gly His Asn 
145                 150                 155                 160 


Phe Thr Ala Gly Asp Leu Gly Pro Ser Thr Ile Val Gly Ser Ala Ala 
                165                 170                 175     


Phe Asn Met Phe Ile Ile Ile Ala Leu Cys Val Tyr Val Val Pro Asp 
            180                 185                 190         


Gly Glu Thr Arg Lys Ile Lys His Leu Arg Val Phe Phe Val Thr Ala 
        195                 200                 205             


Ala Trp Ser Ile Phe Ala Tyr Thr Trp Leu Tyr Ile Ile Leu Ser Val 
    210                 215                 220                 


Ile Ser Pro Gly Val Val Glu Val Trp Glu Gly Leu Leu Thr Phe Phe 
225                 230                 235                 240 


Phe Phe Pro Ile Cys Val Val Phe Ala Trp Val Ala Asp Arg Arg Leu 
                245                 250                 255     


Leu Phe Tyr Lys Tyr Val Tyr Lys Arg Tyr Arg Ala Gly Lys Gln Arg 
            260                 265                 270         


Gly Met Ile Ile Glu His Glu Gly Asp Arg Pro Ser Ser Lys Thr Glu 
        275                 280                 285             


Ile Glu Met Asp Gly Lys Val Val Asn Ser His Val Glu Asn Phe Leu 
    290                 295                 300                 


Asp Gly Ala Leu Val Leu Glu Val Asp Glu Arg Asp Gln Asp Asp Glu 
305                 310                 315                 320 


Glu Ala Arg Arg Glu Met Ala Arg Ile Leu Lys Glu Leu Lys Gln Lys 
                325                 330                 335     


His Pro Asp Lys Glu Ile Glu Gln Leu Ile Glu Leu Ala Asn Tyr Gln 
            340                 345                 350         


Val Leu Ser Gln Gln Gln Lys Ser Arg Ala Phe Tyr Arg Ile Gln Ala 
        355                 360                 365             


Thr Arg Leu Met Thr Gly Ala Gly Asn Ile Leu Lys Arg His Ala Ala 
    370                 375                 380                 


Asp Gln Ala Arg Lys Ala Val Ser Met His Glu Val Asn Thr Glu Val 
385                 390                 395                 400 


Thr Glu Asn Asp Pro Val Ser Lys Ile Phe Phe Glu Gln Gly Thr Tyr 
                405                 410                 415     


Gln Cys Leu Glu Asn Cys Gly Thr Val Ala Leu Thr Ile Ile Arg Arg 
            420                 425                 430         


Gly Gly Asp Leu Thr Asn Thr Val Phe Val Asp Phe Arg Thr Glu Asp 
        435                 440                 445             


Gly Thr Ala Asn Ala Gly Ser Asp Tyr Glu Phe Thr Glu Gly Thr Val 
    450                 455                 460                 


Val Phe Lys Pro Gly Asp Thr Gln Lys Glu Ile Arg Val Gly Ile Ile 
465                 470                 475                 480 


Asp Asp Asp Ile Phe Glu Glu Asp Glu Asn Phe Leu Val His Leu Ser 
                485                 490                 495     


Asn Val Lys Val Ser Ser Glu Ala Ser Glu Asp Gly Ile Leu Glu Ala 
            500                 505                 510         


Asn His Val Ser Thr Leu Ala Cys Leu Gly Ser Pro Ser Thr Ala Thr 
        515                 520                 525             


Val Thr Ile Phe Asp Asp Asp His Ala Gly Ile Phe Thr Phe Glu Glu 
    530                 535                 540                 


Pro Val Thr His Val Ser Glu Ser Ile Gly Ile Met Glu Val Lys Val 
545                 550                 555                 560 


Leu Arg Thr Ser Gly Ala Arg Gly Asn Val Ile Val Pro Tyr Lys Thr 
                565                 570                 575     


Ile Glu Gly Thr Ala Arg Gly Gly Gly Glu Asp Phe Glu Asp Thr Cys 
            580                 585                 590         


Gly Glu Leu Glu Phe Gln Asn Asp Glu Ile Val Lys Thr Ile Ser Val 
        595                 600                 605             


Lys Val Ile Asp Asp Glu Glu Tyr Glu Lys Asn Lys Thr Phe Phe Leu 
    610                 615                 620                 


Glu Ile Gly Glu Pro Arg Leu Val Glu Met Ser Glu Lys Lys Ala Leu 
625                 630                 635                 640 


Leu Leu Asn Glu Leu Gly Gly Phe Thr Ile Thr Gly Gln Pro Val Phe 
                645                 650                 655     


Arg Lys Val His Ala Arg Glu His Pro Ile Leu Ser Thr Val Ile Thr 
            660                 665                 670         


Ile Ala Asp Glu Tyr Asp Asp Lys Gln Pro Leu Thr Ser Lys Glu Glu 
        675                 680                 685             


Glu Glu Arg Arg Ile Ala Glu Met Gly Arg Pro Ile Leu Gly Glu His 
    690                 695                 700                 


Thr Lys Leu Glu Val Ile Ile Glu Glu Ser Tyr Glu Phe Lys Ser Thr 
705                 710                 715                 720 


Val Asp Lys Leu Ile Lys Lys Thr Asn Leu Ala Leu Val Val Gly Thr 
                725                 730                 735     


Asn Ser Trp Arg Glu Gln Phe Ile Glu Ala Ile Thr Val Ser Ala Gly 
            740                 745                 750         


Glu Asp Asp Asp Asp Asp Glu Cys Gly Glu Glu Lys Leu Pro Ser Cys 
        755                 760                 765             


Phe Asp Tyr Val Met His Phe Leu Thr Val Phe Trp Lys Val Leu Phe 
    770                 775                 780                 


Ala Phe Val Pro Pro Thr Glu Tyr Trp Asn Gly Trp Ala Cys Phe Ile 
785                 790                 795                 800 


Val Ser Ile Leu Met Ile Gly Leu Leu Thr Ala Phe Ile Gly Asp Leu 
                805                 810                 815     


Ala Ser His Phe Gly Cys Thr Ile Gly Leu Lys Asp Ser Val Thr Ala 
            820                 825                 830         


Val Val Phe Val Ala Leu Gly Thr Ser Val Pro Asp Thr Phe Ala Ser 
        835                 840                 845             


Lys Val Ala Ala Thr Gln Asp Gln Tyr Ala Asp Ala Ser Ile Gly Asn 
    850                 855                 860                 


Val Thr Gly Ser Asn Ala Val Asn Val Phe Leu Gly Ile Gly Val Ala 
865                 870                 875                 880 


Trp Ser Ile Ala Ala Ile Tyr His Ala Ala Asn Gly Glu Gln Phe Lys 
                885                 890                 895     


Val Ser Pro Gly Thr Leu Ala Phe Ser Val Thr Leu Phe Thr Ile Phe 
            900                 905                 910         


Ala Phe Ile Asn Val Gly Val Leu Leu Tyr Arg Arg Arg Pro Glu Ile 
        915                 920                 925             


Gly Gly Glu Leu Gly Gly Pro Arg Thr Ala Lys Leu Leu Thr Ser Cys 
    930                 935                 940                 


Leu Phe Val Leu Leu Trp Leu Leu Tyr Ile Phe Phe Ser Ser Leu Glu 
945                 950                 955                 960 


Ala Tyr Cys His Ile Lys Gly Phe 
                965             


<210>  200
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Gly Leu Thr Leu Leu Leu Leu Leu Leu Leu Gly Leu Glu Gly Gln 
1               5                   10                  15      


Gly Ile Val Gly Ser Leu Pro Glu Val Leu Gln Ala Pro Val Gly Ser 
            20                  25                  30          


Ser Ile Leu Val Gln Cys His Tyr Arg Leu Gln Asp Val Lys Ala Gln 
        35                  40                  45              


Lys Val Trp Cys Arg Phe Leu Pro Glu Gly Cys Gln Pro Leu Val Ser 
    50                  55                  60                  


Ser Ala Val Asp Arg Arg Ala Pro Ala Gly Arg Arg Thr Phe Leu Thr 
65                  70                  75                  80  


Asp Leu Gly Gly Gly Leu Leu Gln Val Glu Met Val Thr Leu Gln Glu 
                85                  90                  95      


Glu Asp Ala Gly Glu Tyr Gly Cys Met Val Asp Gly Ala Arg Gly Pro 
            100                 105                 110         


Gln Ile Leu His Arg Val Ser Leu Asn Ile Leu Pro Pro Glu Glu Glu 
        115                 120                 125             


Glu Glu Thr His Lys Ile Gly Ser Leu Ala Glu Asn Ala Phe Ser Asp 
    130                 135                 140                 


Pro Ala Gly Ser Ala Asn Pro Leu Glu Pro Ser Gln Asp Glu Lys Ser 
145                 150                 155                 160 


Ile Pro Leu Ile Trp Gly Ala Val Leu Leu Val Gly Leu Leu Val Ala 
                165                 170                 175     


Ala Val Val Leu Phe Ala Val Met Ala Lys Arg Lys Gln Gly Asn Arg 
            180                 185                 190         


Leu Gly Val Cys Gly Arg Phe Leu Ser Ser Arg Val Ser Gly Met Asn 
        195                 200                 205             


Pro Ser Ser Val Val His His Val Ser Asp Ser Gly Pro Ala Ala Glu 
    210                 215                 220                 


Leu Pro Leu Asp Val Pro His Ile Arg Leu Asp Ser Pro Pro Ser Phe 
225                 230                 235                 240 


Asp Asn Thr Thr Tyr Thr Ser Leu Pro Leu Asp Ser Pro Ser Gly Lys 
                245                 250                 255     


Pro Ser Leu Pro Ala Pro Ser Ser Leu Pro Pro Leu Pro Pro Lys Val 
            260                 265                 270         


Leu Val Cys Ser Lys Pro Val Thr Tyr Ala Thr Val Ile Phe Pro Gly 
        275                 280                 285             


Gly Asn Lys Gly Gly Gly Thr Ser Cys Gly Pro Ala Gln Asn Pro Pro 
    290                 295                 300                 


Asn Asn Gln Thr Pro Ser Ser 
305                 310     


<210>  201
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Gly Leu Thr Leu Leu Leu Leu Leu Leu Leu Gly Leu Glu Gly Gln 
1               5                   10                  15      


Gly Ile Val Gly Ser Leu Pro Glu Val Leu Gln Ala Pro Val Gly Ser 
            20                  25                  30          


Ser Ile Leu Val Gln Cys His Tyr Arg Leu Gln Asp Val Lys Ala Gln 
        35                  40                  45              


Lys Val Trp Cys Arg Phe Leu Pro Glu Gly Cys Gln Pro Leu Val Ser 
    50                  55                  60                  


Ser Ala Val Asp Arg Arg Ala Pro Ala Gly Arg Arg Thr Phe Leu Thr 
65                  70                  75                  80  


Asp Leu Gly Gly Gly Leu Leu Gln Val Glu Met Val Thr Leu Gln Glu 
                85                  90                  95      


Glu Asp Ala Gly Glu Tyr Gly Cys Met Val Asp Gly Ala Arg Gly Pro 
            100                 105                 110         


Gln Ile Leu His Arg Val Ser Leu Asn Ile Leu Pro Pro Glu Glu Glu 
        115                 120                 125             


Glu Glu Thr His Lys Ile Gly Ser Leu Ala Glu Asn Ala Phe Ser Asp 
    130                 135                 140                 


Pro Ala Gly Ser Ala Asn Pro Leu Glu Pro Ser Gln Asp Glu Lys Ser 
145                 150                 155                 160 


Ile Pro Leu Ile Trp Gly Ala Val Leu Leu Val Gly Leu Leu Val Ala 
                165                 170                 175     


Ala Val Val Leu Phe Ala Val Met Ala Lys Arg Lys Gln Glu Ser Leu 
            180                 185                 190         


Leu Ser Gly Pro Pro Arg Gln 
        195                 


<210>  202
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Gly Leu Thr Leu Leu Leu Leu Leu Leu Leu Gly Leu Glu Glu Glu 
1               5                   10                  15      


Glu Glu Glu Thr His Lys Ile Gly Ser Leu Ala Glu Asn Ala Phe Ser 
            20                  25                  30          


Asp Pro Ala Gly Ser Ala Asn Pro Leu Glu Pro Ser Gln Asp Glu Lys 
        35                  40                  45              


Ser Ile Pro Leu Ile Trp Gly Ala Val Leu Leu Val Gly Leu Leu Val 
    50                  55                  60                  


Ala Ala Val Val Leu Phe Ala Val Met Ala Lys Arg Lys Gln Gly Asn 
65                  70                  75                  80  


Arg Leu Gly Val Cys Gly Arg Phe Leu Ser Ser Arg Val Ser Gly Met 
                85                  90                  95      


Asn Pro Ser Ser Val Val His His Val Ser Asp Ser Gly Pro Ala Ala 
            100                 105                 110         


Glu Leu Pro Leu Asp Val Pro His Ile Arg Leu Asp Ser Pro Pro Ser 
        115                 120                 125             


Phe Asp Asn Thr Thr Tyr Thr Ser Leu Pro Leu Asp Ser Pro Ser Gly 
    130                 135                 140                 


Lys Pro Ser Leu Pro Ala Pro Ser Ser Leu Pro Pro Leu Pro Pro Lys 
145                 150                 155                 160 


Val Leu Val Cys Ser Lys Pro Val Thr Tyr Ala Thr Val Ile Phe Pro 
                165                 170                 175     


Gly Gly Asn Lys Gly Gly Gly Thr Ser Cys Gly Pro Ala Gln Asn Pro 
            180                 185                 190         


Pro Asn Asn Gln Thr Pro Ser Ser 
        195                 200 


<210>  203
<211>  1037
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Ser Pro Pro Leu Cys Pro Leu Leu Leu Leu Ala Val Gly Leu Arg 
1               5                   10                  15      


Leu Ala Gly Thr Leu Asn Pro Ser Asp Pro Asn Thr Cys Ser Phe Trp 
            20                  25                  30          


Glu Ser Phe Thr Thr Thr Thr Lys Glu Ser His Ser Arg Pro Phe Ser 
        35                  40                  45              


Leu Leu Pro Ser Glu Pro Cys Glu Arg Pro Trp Glu Gly Pro His Thr 
    50                  55                  60                  


Cys Pro Gln Pro Thr Val Val Tyr Arg Thr Val Tyr Arg Gln Val Val 
65                  70                  75                  80  


Lys Thr Asp His Arg Gln Arg Leu Gln Cys Cys His Gly Phe Tyr Glu 
                85                  90                  95      


Ser Arg Gly Phe Cys Val Pro Leu Cys Ala Gln Glu Cys Val His Gly 
            100                 105                 110         


Arg Cys Val Ala Pro Asn Gln Cys Gln Cys Val Pro Gly Trp Arg Gly 
        115                 120                 125             


Asp Asp Cys Ser Ser Glu Cys Ala Pro Gly Met Trp Gly Pro Gln Cys 
    130                 135                 140                 


Asp Lys Pro Cys Ser Cys Gly Asn Asn Ser Ser Cys Asp Pro Lys Ser 
145                 150                 155                 160 


Gly Val Cys Ser Cys Pro Ser Gly Leu Gln Pro Pro Asn Cys Leu Gln 
                165                 170                 175     


Pro Cys Thr Pro Gly Tyr Tyr Gly Pro Ala Cys Gln Phe Arg Cys Gln 
            180                 185                 190         


Cys His Gly Ala Pro Cys Asp Pro Gln Thr Gly Ala Cys Phe Cys Pro 
        195                 200                 205             


Ala Glu Arg Thr Gly Pro Ser Cys Asp Val Ser Cys Ser Gln Gly Thr 
    210                 215                 220                 


Ser Gly Phe Phe Cys Pro Ser Thr His Ser Cys Gln Asn Gly Gly Val 
225                 230                 235                 240 


Phe Gln Thr Pro Gln Gly Ser Cys Ser Cys Pro Pro Gly Trp Met Gly 
                245                 250                 255     


Thr Ile Cys Ser Leu Pro Cys Pro Glu Gly Phe His Gly Pro Asn Cys 
            260                 265                 270         


Ser Gln Glu Cys Arg Cys His Asn Gly Gly Leu Cys Asp Arg Phe Thr 
        275                 280                 285             


Gly Gln Cys Arg Cys Ala Pro Gly Tyr Thr Gly Asp Arg Cys Arg Glu 
    290                 295                 300                 


Glu Cys Pro Val Gly Arg Phe Gly Gln Asp Cys Ala Glu Thr Cys Asp 
305                 310                 315                 320 


Cys Ala Pro Asp Ala Arg Cys Phe Pro Ala Asn Gly Ala Cys Leu Cys 
                325                 330                 335     


Glu His Gly Phe Thr Gly Asp Arg Cys Thr Asp Arg Leu Cys Pro Asp 
            340                 345                 350         


Gly Phe Tyr Gly Leu Ser Cys Gln Ala Pro Cys Thr Cys Asp Arg Glu 
        355                 360                 365             


His Ser Leu Ser Cys His Pro Met Asn Gly Glu Cys Ser Cys Leu Pro 
    370                 375                 380                 


Gly Trp Ala Gly Leu His Cys Asn Glu Ser Cys Pro Gln Asp Thr His 
385                 390                 395                 400 


Gly Pro Gly Cys Gln Glu His Cys Leu Cys Leu His Gly Gly Val Cys 
                405                 410                 415     


Gln Ala Thr Ser Gly Leu Cys Gln Cys Ala Pro Gly Tyr Thr Gly Pro 
            420                 425                 430         


His Cys Ala Ser Leu Cys Pro Pro Asp Thr Tyr Gly Val Asn Cys Ser 
        435                 440                 445             


Ala Arg Cys Ser Cys Glu Asn Ala Ile Ala Cys Ser Pro Ile Asp Gly 
    450                 455                 460                 


Glu Cys Val Cys Lys Glu Gly Trp Gln Arg Gly Asn Cys Ser Val Pro 
465                 470                 475                 480 


Cys Pro Pro Gly Thr Trp Gly Phe Ser Cys Asn Ala Ser Cys Gln Cys 
                485                 490                 495     


Ala His Glu Ala Val Cys Ser Pro Gln Thr Gly Ala Cys Thr Cys Thr 
            500                 505                 510         


Pro Gly Trp His Gly Ala His Cys Gln Leu Pro Cys Pro Lys Gly Gln 
        515                 520                 525             


Phe Gly Glu Gly Cys Ala Ser Arg Cys Asp Cys Asp His Ser Asp Gly 
    530                 535                 540                 


Cys Asp Pro Val His Gly Arg Cys Gln Cys Gln Ala Gly Trp Met Gly 
545                 550                 555                 560 


Ala Arg Cys His Leu Ser Cys Pro Glu Gly Leu Trp Gly Val Asn Cys 
                565                 570                 575     


Ser Asn Thr Cys Thr Cys Lys Asn Gly Gly Thr Cys Leu Pro Glu Asn 
            580                 585                 590         


Gly Asn Cys Val Cys Ala Pro Gly Phe Arg Gly Pro Ser Cys Gln Arg 
        595                 600                 605             


Ser Cys Gln Pro Gly Arg Tyr Gly Lys Arg Cys Val Pro Cys Lys Cys 
    610                 615                 620                 


Ala Asn His Ser Phe Cys His Pro Ser Asn Gly Thr Cys Tyr Cys Leu 
625                 630                 635                 640 


Ala Gly Trp Thr Gly Pro Asp Cys Ser Gln Pro Cys Pro Pro Gly His 
                645                 650                 655     


Trp Gly Glu Asn Cys Ala Gln Thr Cys Gln Cys His His Gly Gly Thr 
            660                 665                 670         


Cys His Pro Gln Asp Gly Ser Cys Ile Cys Pro Leu Gly Trp Thr Gly 
        675                 680                 685             


His His Cys Leu Glu Gly Cys Pro Leu Gly Thr Phe Gly Ala Asn Cys 
    690                 695                 700                 


Ser Gln Pro Cys Gln Cys Gly Pro Gly Glu Lys Cys His Pro Glu Thr 
705                 710                 715                 720 


Gly Ala Cys Val Cys Pro Pro Gly His Ser Gly Ala Pro Cys Arg Ile 
                725                 730                 735     


Gly Ile Gln Glu Pro Phe Thr Val Met Pro Thr Thr Pro Val Ala Tyr 
            740                 745                 750         


Asn Ser Leu Gly Ala Val Ile Gly Ile Ala Val Leu Gly Ser Leu Val 
        755                 760                 765             


Val Ala Leu Val Ala Leu Phe Ile Gly Tyr Arg His Trp Gln Lys Gly 
    770                 775                 780                 


Lys Glu His His His Leu Ala Val Ala Tyr Ser Ser Gly Arg Leu Asp 
785                 790                 795                 800 


Gly Ser Glu Tyr Val Met Pro Asp Val Pro Pro Ser Tyr Ser His Tyr 
                805                 810                 815     


Tyr Ser Asn Pro Ser Tyr His Thr Leu Ser Gln Cys Ser Pro Asn Pro 
            820                 825                 830         


Pro Pro Pro Asn Lys Val Pro Gly Pro Leu Phe Ala Ser Leu Gln Asn 
        835                 840                 845             


Pro Glu Arg Pro Gly Gly Ala Gln Gly His Asp Asn His Thr Thr Leu 
    850                 855                 860                 


Pro Ala Asp Trp Lys His Arg Arg Glu Pro Pro Pro Gly Pro Leu Asp 
865                 870                 875                 880 


Arg Gly Ser Ser Arg Leu Asp Arg Ser Tyr Ser Tyr Ser Tyr Ser Asn 
                885                 890                 895     


Gly Pro Gly Pro Phe Tyr Asn Lys Gly Leu Ile Ser Glu Glu Glu Leu 
            900                 905                 910         


Gly Ala Ser Val Ala Ser Leu Ser Ser Glu Asn Pro Tyr Ala Thr Ile 
        915                 920                 925             


Arg Asp Leu Pro Ser Leu Pro Gly Gly Pro Arg Glu Ser Ser Tyr Met 
    930                 935                 940                 


Glu Met Lys Gly Pro Pro Ser Gly Ser Pro Pro Arg Gln Pro Pro Gln 
945                 950                 955                 960 


Phe Trp Asp Ser Gln Arg Arg Arg Gln Pro Gln Pro Gln Arg Asp Ser 
                965                 970                 975     


Gly Thr Tyr Glu Gln Pro Ser Pro Leu Ile His Asp Arg Asp Ser Val 
            980                 985                 990         


Gly Ser Gln Pro Pro Leu Pro Pro  Gly Leu Pro Pro Gly  His Tyr Asp 
        995                 1000                 1005             


Ser Pro  Lys Asn Ser His Ile  Pro Gly His Tyr Asp  Leu Pro Pro 
    1010                 1015                 1020             


Val Arg  His Pro Pro Ser Pro  Pro Leu Arg Arg Gln  Asp Arg 
    1025                 1030                 1035         


<210>  204
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Glu Arg Ala Ser Leu Ile Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Glu Asp Met Ala Ala Phe Met Lys Gly Ala Val Glu Lys 
            20                  25                  30          


Gly Glu Glu Leu Ser Cys Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Gly Gln Arg Ala Ala Trp Arg Val Leu Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Ser Asn Glu Glu Gly Ser Glu Glu Lys Gly Pro Glu 
65                  70                  75                  80  


Val Arg Glu Tyr Arg Glu Lys Val Glu Thr Glu Leu Gln Gly Val Cys 
                85                  90                  95      


Asp Thr Val Leu Gly Leu Leu Asp Ser His Leu Ile Lys Glu Ala Gly 
            100                 105                 110         


Asp Ala Glu Ser Arg Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr 
        115                 120                 125             


Arg Tyr Leu Ala Glu Val Ala Thr Gly Asp Asp Lys Lys Arg Ile Ile 
    130                 135                 140                 


Asp Ser Ala Arg Ser Ala Tyr Gln Glu Ala Met Asp Ile Ser Lys Lys 
145                 150                 155                 160 


Glu Met Pro Pro Thr Asn Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe 
                165                 170                 175     


Ser Val Phe His Tyr Glu Ile Ala Asn Ser Pro Glu Glu Ala Ile Ser 
            180                 185                 190         


Leu Ala Lys Thr Thr Phe Asp Glu Ala Met Ala Asp Leu His Thr Leu 
        195                 200                 205             


Ser Glu Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg 
    210                 215                 220                 


Asp Asn Leu Thr Leu Trp Thr Ala Asp Asn Ala Gly Glu Glu Gly Gly 
225                 230                 235                 240 


Glu Ala Pro Gln Glu Pro Gln Ser 
                245             


<210>  205
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Glu Arg Ala Ser Leu Ile Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Glu Asp Met Ala Ala Phe Met Lys Gly Ala Val Glu Lys 
            20                  25                  30          


Gly Glu Glu Leu Ser Cys Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Gly Gln Arg Ala Ala Trp Arg Val Leu Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Ser Asn Glu Glu Gly Ser Glu Glu Lys Gly Pro Glu 
65                  70                  75                  80  


Val Arg Glu Tyr Arg Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr 
                85                  90                  95      


Arg Tyr Leu Ala Glu Val Ala Thr Gly Asp Asp Lys Lys Arg Ile Ile 
            100                 105                 110         


Asp Ser Ala Arg Ser Ala Tyr Gln Glu Ala Met Asp Ile Ser Lys Lys 
        115                 120                 125             


Glu Met Pro Pro Thr Asn Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe 
    130                 135                 140                 


Ser Val Phe His Tyr Glu Ile Ala Asn Ser Pro Glu Glu Ala Ile Ser 
145                 150                 155                 160 


Leu Ala Lys Thr Thr Phe Asp Glu Ala Met Ala Asp Leu His Thr Leu 
                165                 170                 175     


Ser Glu Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg 
            180                 185                 190         


Asp Asn Leu Thr Leu Trp Thr Ala Asp Asn Ala Gly Glu Glu Gly Gly 
        195                 200                 205             


Glu Ala Pro Gln Glu Pro Gln Ser 
    210                 215     


<210>  206
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val 
                85                  90                  95      


Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 
            100                 105                 110         


Leu Ala Tyr Ser Arg Leu Lys Glu Leu Thr Leu Glu Asp Leu Lys Ile 
        115                 120                 125             


Thr Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu 
    130                 135                 140                 


Ser Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp 
145                 150                 155                 160 


Leu Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser 
                165                 170                 175     


Ile Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala 
            180                 185                 190         


Phe Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly 
        195                 200                 205             


Glu Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile 
    210                 215                 220                 


Gln Asn Leu Ala Leu Arg Asn Thr Gly Met Glu Thr Pro Thr Gly Val 
225                 230                 235                 240 


Cys Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu 
                245                 250                 255     


Ser His Asn Ser Leu Arg Ala Thr Val Asn Pro Ser Ala Pro Arg Cys 
            260                 265                 270         


Met Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu 
        275                 280                 285             


Glu Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu 
    290                 295                 300                 


Ser Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu 
305                 310                 315                 320 


Val Asp Asn Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr 
                325                 330                 335     


Ala Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys 
            340                 345                 350         


Ala Arg Ser Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu 
        355                 360                 365             


Gln Gly Ala Arg Gly Phe Ala 
    370                 375 


<210>  207
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Gln Ser Pro Trp Lys Ile Leu Thr Val Ala Pro Leu Phe Leu Leu 
1               5                   10                  15      


Leu Ser Leu Gln Ser Ser Ala Ser Pro Ala Asn Asp Asp Gln Ser Arg 
            20                  25                  30          


Pro Ser Leu Ser Asn Gly His Thr Cys Val Gly Cys Val Leu Val Val 
        35                  40                  45              


Ser Val Ile Glu Gln Leu Ala Gln Val His Asn Ser Thr Val Gln Ala 
    50                  55                  60                  


Ser Met Glu Arg Leu Cys Ser Tyr Leu Pro Glu Lys Leu Phe Leu Lys 
65                  70                  75                  80  


Thr Thr Cys Tyr Leu Val Ile Asp Lys Phe Gly Ser Asp Ile Ile Lys 
                85                  90                  95      


Leu Leu Ser Ala Asp Met Asn Ala Asp Val Val Cys His Thr Leu Glu 
            100                 105                 110         


Phe Cys Lys Gln Asn Thr Gly Gln Pro Leu Cys His Leu Tyr Pro Leu 
        115                 120                 125             


Pro Lys Glu Thr Trp Lys Phe Thr Leu Gln Lys Ala Arg Gln Ile Val 
    130                 135                 140                 


Lys Lys Ser Pro Ile Leu Lys Tyr Ser Arg Ser Gly Ser Asp Ile Cys 
145                 150                 155                 160 


Ser Leu Pro Val Leu Ala Lys Ile Cys Gln Lys Ile Lys Leu Ala Met 
                165                 170                 175     


Glu Gln Ser Val Pro Phe Lys Asp Val Asp Ser Asp Lys Tyr Ser Val 
            180                 185                 190         


Phe Pro Thr Leu Arg Gly Tyr His Trp Arg Gly Arg Asp Cys Asn Asp 
        195                 200                 205             


Ser Asp Glu Ser Val Tyr Pro Gly Arg Arg Pro Asn Asn Trp Asp Val 
    210                 215                 220                 


His Gln Asp Ser Asn Cys Asn Gly Ile Trp Gly Val Asp Pro Lys Asp 
225                 230                 235                 240 


Gly Val Pro Tyr Glu Lys Lys Phe Cys Glu Gly Ser Gln Pro Arg Gly 
                245                 250                 255     


Ile Ile Leu Leu Gly Asp Ser Ala Gly Ala His Phe His Ile Ser Pro 
            260                 265                 270         


Glu Trp Ile Thr Ala Ser Gln Met Ser Leu Asn Ser Phe Ile Asn Leu 
        275                 280                 285             


Pro Thr Ala Leu Thr Asn Glu Leu Asp Trp Pro Gln Leu Ser Gly Ala 
    290                 295                 300                 


Thr Gly Phe Leu Asp Ser Thr Val Gly Ile Lys Glu Lys Ser Ile Tyr 
305                 310                 315                 320 


Leu Arg Leu Trp Lys Arg Asn His Cys Asn His Arg Asp Tyr Gln Asn 
                325                 330                 335     


Ile Ser Arg Asn Gly Ala Ser Ser Arg Asn Leu Lys Lys Phe Ile Glu 
            340                 345                 350         


Ser Leu Ser Arg Asn Lys Val Leu Asp Tyr Pro Ala Ile Val Ile Tyr 
        355                 360                 365             


Ala Met Ile Gly Asn Asp Val Cys Ser Gly Lys Ser Asp Pro Val Pro 
    370                 375                 380                 


Ala Met Thr Thr Pro Glu Lys Leu Tyr Ser Asn Val Met Gln Thr Leu 
385                 390                 395                 400 


Lys His Leu Asn Ser His Leu Pro Asn Gly Ser His Val Ile Leu Tyr 
                405                 410                 415     


Gly Leu Pro Asp Gly Thr Phe Leu Trp Asp Asn Leu His Asn Arg Tyr 
            420                 425                 430         


His Pro Leu Gly Gln Leu Asn Lys Asp Met Thr Tyr Ala Gln Leu Tyr 
        435                 440                 445             


Ser Phe Leu Asn Cys Leu Gln Val Ser Pro Cys His Gly Trp Met Ser 
    450                 455                 460                 


Ser Asn Lys Thr Leu Arg Thr Leu Thr Ser Glu Arg Ala Glu Gln Leu 
465                 470                 475                 480 


Ser Asn Thr Leu Lys Lys Ile Ala Ala Ser Glu Lys Phe Thr Asn Phe 
                485                 490                 495     


Asn Leu Phe Tyr Met Asp Phe Ala Phe His Glu Ile Ile Gln Glu Trp 
            500                 505                 510         


Gln Lys Arg Gly Gly Gln Pro Trp Gln Leu Ile Glu Pro Val Asp Gly 
        515                 520                 525             


Phe His Pro Asn Glu Val Ala Leu Leu Leu Leu Ala Asp His Phe Trp 
    530                 535                 540                 


Lys Lys Val Gln Leu Gln Trp Pro Gln Ile Leu Gly Lys Glu Asn Pro 
545                 550                 555                 560 


Phe Asn Pro Gln Ile Lys Gln Val Phe Gly Asp Gln Gly Gly His 
                565                 570                 575 


<210>  208
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Gln Ser Pro Trp Lys Ile Leu Thr Val Ala Pro Leu Phe Leu Leu 
1               5                   10                  15      


Leu Ser Leu Gln Ser Ser Ala Ser Pro Ala Asn Asp Asp Gln Ser Arg 
            20                  25                  30          


Pro Ser Leu Ser Asn Gly His Thr Cys Val Glu Lys Leu Phe Leu Lys 
        35                  40                  45              


Thr Thr Cys Tyr Leu Val Ile Asp Lys Phe Gly Ser Asp Ile Ile Lys 
    50                  55                  60                  


Leu Leu Ser Ala Asp Met Asn Ala Asp Val Val Cys His Thr Leu Glu 
65                  70                  75                  80  


Phe Cys Lys Gln Asn Thr Gly Gln Pro Leu Cys His Leu Tyr Pro Leu 
                85                  90                  95      


Pro Lys Glu Thr Trp Lys Phe Thr Leu Gln Lys Ala Arg Gln Ile Val 
            100                 105                 110         


Lys Lys Ser Pro Ile Leu Lys Tyr Ser Arg Ser Gly Ser Asp Ile Cys 
        115                 120                 125             


Ser Leu Pro Val Leu Ala Lys Ile Cys Gln Lys Ile Lys Leu Ala Met 
    130                 135                 140                 


Glu Gln Ser Val Pro Phe Lys Asp Val Asp Ser Asp Lys Tyr Ser Val 
145                 150                 155                 160 


Phe Pro Thr Leu Arg Gly Tyr His Trp Arg Gly Arg Asp Cys Asn Asp 
                165                 170                 175     


Ser Asp Glu Ser Val Tyr Pro Gly Arg Arg Pro Asn Asn Trp Asp Val 
            180                 185                 190         


His Gln Asp Ser Asn Cys Asn Gly Ile Trp Gly Val Asp Pro Lys Asp 
        195                 200                 205             


Gly Val Pro Tyr Glu Lys Lys Phe Cys Glu Gly Ser Gln Pro Arg Gly 
    210                 215                 220                 


Ile Ile Leu Leu Gly Asp Ser Ala Gly Ala His Phe His Ile Ser Pro 
225                 230                 235                 240 


Glu Trp Ile Thr Ala Ser Gln Met Ser Leu Asn Ser Phe Ile Asn Leu 
                245                 250                 255     


Pro Thr Ala Leu Thr Asn Glu Leu Asp Trp Pro Gln Leu Ser Gly Ala 
            260                 265                 270         


Thr Gly Phe Leu Asp Ser Thr Val Gly Ile Lys Glu Lys Ser Ile Tyr 
        275                 280                 285             


Leu Arg Leu Trp Lys Arg Asn His Cys Asn His Arg Asp Tyr Gln Asn 
    290                 295                 300                 


Ile Ser Arg Asn Gly Ala Ser Ser Arg Asn Leu Lys Lys Phe Ile Glu 
305                 310                 315                 320 


Ser Leu Ser Arg Asn Lys Val Leu Asp Tyr Pro Ala Ile Val Ile Tyr 
                325                 330                 335     


Ala Met Ile Gly Asn Asp Val Cys Ser Gly Lys Ser Asp Pro Val Pro 
            340                 345                 350         


Ala Met Thr Thr Pro Glu Lys Leu Tyr Ser Asn Val Met Gln Thr Leu 
        355                 360                 365             


Lys His Leu Asn Ser His Leu Pro Asn Gly Ser His Val Ile Leu Tyr 
    370                 375                 380                 


Gly Leu Pro Asp Gly Thr Phe Leu Trp Asp Asn Leu His Asn Arg Tyr 
385                 390                 395                 400 


His Pro Leu Gly Gln Leu Asn Lys Asp Met Thr Tyr Ala Gln Leu Tyr 
                405                 410                 415     


Ser Phe Leu Asn Cys Leu Gln Val Ser Pro Cys His Gly Trp Met Ser 
            420                 425                 430         


Ser Asn Lys Thr Leu Arg Thr Leu Thr Ser Glu Arg Ala Glu Gln Leu 
        435                 440                 445             


Ser Asn Thr Leu Lys Lys Ile Ala Ala Ser Glu Lys Phe Thr Asn Phe 
    450                 455                 460                 


Asn Leu Phe Tyr Met Asp Phe Ala Phe His Glu Ile Ile Gln Glu Trp 
465                 470                 475                 480 


Gln Lys Arg Gly Gly Gln Pro Trp Gln Leu Ile Glu Pro Val Asp Gly 
                485                 490                 495     


Phe His Pro Asn Glu Val Ala Leu Leu Leu Leu Ala Asp His Phe Trp 
            500                 505                 510         


Lys Lys Val Gln Leu Gln Trp Pro Gln Ile Leu Gly Lys Glu Asn Pro 
        515                 520                 525             


Phe Asn Pro Gln Ile Lys Gln Val Phe Gly Asp Gln Gly Gly His 
    530                 535                 540             


<210>  209
<211>  339
<212>  PRT
<213>  Mus musculus

<400>  209

Met Arg Asn Pro Gly Gly Pro Gly Trp Ala Ser Lys Arg Pro Leu Gln 
1               5                   10                  15      


Lys Lys Gln Asn Thr Ala Cys Leu Cys Ala Gln Gln Pro Ala Arg His 
            20                  25                  30          


Phe Val Pro Ala Pro Phe Asn Ser Ser Arg Gln Gly Lys Asn Thr Ala 
        35                  40                  45              


Gln Pro Thr Glu Pro Ser Leu Ser Ser Val Ile Ala Pro Thr Leu Phe 
    50                  55                  60                  


Cys Ala Phe Leu Tyr Leu Ala Cys Val Thr Ala Glu Leu Pro Glu Val 
65                  70                  75                  80  


Ser Arg Arg Met Ala Thr Ser Gly Val Arg Ser Lys Glu Gly Arg Arg 
                85                  90                  95      


Glu His Ala Phe Val Pro Glu Pro Phe Thr Gly Thr Asn Leu Ala Pro 
            100                 105                 110         


Ser Leu Trp Leu His Arg Phe Glu Val Ile Asp Asp Leu Asn His Trp 
        115                 120                 125             


Asp His Ala Thr Lys Leu Arg Phe Leu Lys Glu Ser Leu Lys Gly Asp 
    130                 135                 140                 


Ala Leu Asp Val Tyr Asn Gly Leu Ser Ser Gln Ala Gln Gly Asp Phe 
145                 150                 155                 160 


Ser Phe Val Lys Gln Ala Leu Leu Arg Ala Phe Gly Ala Pro Gly Glu 
                165                 170                 175     


Ala Phe Ser Glu Pro Glu Glu Ile Leu Phe Ala Asn Ser Met Gly Lys 
            180                 185                 190         


Gly Tyr Tyr Leu Lys Gly Lys Val Gly His Val Pro Val Arg Phe Leu 
        195                 200                 205             


Val Asp Ser Gly Ala Gln Val Ser Val Val His Pro Ala Leu Trp Glu 
    210                 215                 220                 


Glu Val Thr Asp Gly Asp Leu Asp Thr Leu Arg Pro Phe Asn Asn Val 
225                 230                 235                 240 


Val Lys Val Ala Asn Gly Ala Glu Met Lys Ile Leu Gly Val Trp Asp 
                245                 250                 255     


Thr Glu Ile Ser Leu Gly Lys Thr Lys Leu Lys Ala Glu Phe Leu Val 
            260                 265                 270         


Ala Asn Ala Ser Ala Glu Glu Ala Ile Ile Gly Thr Asp Val Leu Gln 
        275                 280                 285             


Asp His Asn Ala Val Leu Asp Phe Glu His Arg Thr Cys Thr Leu Lys 
    290                 295                 300                 


Gly Lys Lys Phe Arg Leu Leu Pro Val Gly Ser Ser Leu Glu Asp Glu 
305                 310                 315                 320 


Phe Asp Leu Glu Leu Ile Glu Glu Glu Glu Gly Ser Ser Ala Pro Glu 
                325                 330                 335     


Gly Ser His 
            


<210>  210
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Phe Ser Trp Val Ser Lys Asp Ala Arg Arg Lys Lys Glu Pro Glu 
1               5                   10                  15      


Leu Phe Gln Thr Val Ala Glu Gly Leu Arg Gln Leu Tyr Ala Gln Lys 
            20                  25                  30          


Leu Leu Pro Leu Glu Glu His Tyr Arg Phe His Glu Phe His Ser Pro 
        35                  40                  45              


Ala Leu Glu Asp Ala Asp Phe Asp Asn Lys Pro Met Val Leu Leu Val 
    50                  55                  60                  


Gly Gln Tyr Ser Thr Gly Lys Thr Thr Phe Ile Arg His Leu Ile Glu 
65                  70                  75                  80  


Gln Asp Phe Pro Gly Met Arg Ile Gly Pro Glu Pro Thr Thr Asp Ser 
                85                  90                  95      


Phe Ile Ala Val Met His Gly Pro Thr Glu Gly Val Val Pro Gly Asn 
            100                 105                 110         


Ala Leu Val Val Asp Pro Arg Arg Pro Phe Arg Lys Leu Asn Ala Phe 
        115                 120                 125             


Gly Asn Ala Phe Leu Asn Arg Phe Met Cys Ala Gln Leu Pro Asn Pro 
    130                 135                 140                 


Val Leu Asp Ser Ile Ser Ile Ile Asp Thr Pro Gly Ile Leu Ser Gly 
145                 150                 155                 160 


Glu Lys Gln Arg Ile Ser Arg Gly Tyr Asp Phe Ala Ala Val Leu Glu 
                165                 170                 175     


Trp Phe Ala Glu Arg Val Asp Arg Ile Ile Leu Leu Phe Asp Ala His 
            180                 185                 190         


Lys Leu Asp Ile Ser Asp Glu Phe Ser Glu Val Ile Lys Ala Leu Lys 
        195                 200                 205             


Asn His Glu Asp Lys Ile Arg Val Val Leu Asn Lys Ala Asp Gln Ile 
    210                 215                 220                 


Glu Thr Gln Gln Leu Met Arg Val Tyr Gly Ala Leu Met Trp Ser Leu 
225                 230                 235                 240 


Gly Lys Ile Ile Asn Thr Pro Glu Val Val Arg Val Tyr Ile Gly Ser 
                245                 250                 255     


Phe Trp Ser His Pro Leu Leu Ile Pro Asp Asn Arg Lys Leu Phe Glu 
            260                 265                 270         


Ala Glu Glu Gln Asp Leu Phe Lys Asp Ile Gln Ser Leu Pro Arg Asn 
        275                 280                 285             


Ala Ala Leu Arg Lys Leu Asn Asp Leu Ile Lys Arg Ala Arg Leu Ala 
    290                 295                 300                 


Lys Val His Ala Tyr Ile Ile Ser Ser Leu Lys Lys Glu Met Pro Asn 
305                 310                 315                 320 


Val Phe Gly Lys Glu Ser Lys Lys Lys Glu Leu Val Asn Asn Leu Gly 
                325                 330                 335     


Glu Ile Tyr Gln Lys Ile Glu Arg Glu His Gln Ile Ser Pro Gly Asp 
            340                 345                 350         


Phe Pro Ser Leu Arg Lys Met Gln Glu Leu Leu Gln Thr Gln Asp Phe 
        355                 360                 365             


Ser Lys Phe Gln Ala Leu Lys Pro Lys Leu Leu Asp Thr Val Asp Asp 
    370                 375                 380                 


Met Leu Ala Asn Asp Ile Ala Arg Leu Met Val Met Val Arg Gln Glu 
385                 390                 395                 400 


Glu Ser Leu Met Pro Ser Gln Val Val Lys Gly Gly Ala Phe Asp Gly 
                405                 410                 415     


Thr Met Asn Gly Pro Phe Gly His Gly Tyr Gly Glu Gly Ala Gly Glu 
            420                 425                 430         


Gly Ile Asp Asp Val Glu Trp Val Val Gly Lys Asp Lys Pro Thr Tyr 
        435                 440                 445             


Asp Glu Ile Phe Tyr Thr Leu Ser Pro Val Asn Gly Lys Ile Thr Gly 
    450                 455                 460                 


Ala Asn Ala Lys Lys Glu Met Val Lys Ser Lys Leu Pro Asn Thr Val 
465                 470                 475                 480 


Leu Gly Lys Ile Trp Lys Leu Ala Asp Val Asp Lys Asp Gly Leu Leu 
                485                 490                 495     


Asp Asp Glu Glu Phe Ala Leu Ala Asn His Leu Ile Lys Val Lys Leu 
            500                 505                 510         


Glu Gly His Glu Leu Pro Ala Asp Leu Pro Pro His Leu Val Pro Pro 
        515                 520                 525             


Ser Lys Arg Arg His Glu 
    530                 


<210>  211
<211>  200
<212>  PRT
<213>  Mus musculus

<400>  211

Met Ala Leu Ser Val Met Cys Leu Gly Leu Ala Leu Leu Gly Val Leu 
1               5                   10                  15      


Gln Ser Gln Ala Gln Asp Ser Thr Gln Asn Leu Ile Pro Ala Pro Ser 
            20                  25                  30          


Leu Leu Thr Val Pro Leu Gln Pro Asp Phe Arg Ser Asp Gln Phe Arg 
        35                  40                  45              


Gly Arg Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Val Gln Lys Lys 
    50                  55                  60                  


Thr Glu Gly Ser Phe Thr Met Tyr Ser Thr Ile Tyr Glu Leu Gln Glu 
65                  70                  75                  80  


Asn Asn Ser Tyr Asn Val Thr Ser Ile Leu Val Arg Asp Gln Asp Gln 
                85                  90                  95      


Gly Cys Arg Tyr Trp Ile Arg Thr Phe Val Pro Ser Ser Arg Ala Gly 
            100                 105                 110         


Gln Phe Thr Leu Gly Asn Met His Arg Tyr Pro Gln Val Gln Ser Tyr 
        115                 120                 125             


Asn Val Gln Val Ala Thr Thr Asp Tyr Asn Gln Phe Ala Met Val Phe 
    130                 135                 140                 


Phe Arg Lys Thr Ser Glu Asn Lys Gln Tyr Phe Lys Ile Thr Leu Tyr 
145                 150                 155                 160 


Gly Arg Thr Lys Glu Leu Ser Pro Glu Leu Lys Glu Arg Phe Thr Arg 
                165                 170                 175     


Phe Ala Lys Ser Leu Gly Leu Lys Asp Asp Asn Ile Ile Phe Ser Val 
            180                 185                 190         


Pro Thr Asp Gln Cys Ile Asp Asn 
        195                 200 


<210>  212
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Arg Gly Tyr Leu Val Ala Ile Phe Leu Ser Ala Val Phe Leu Tyr 
1               5                   10                  15      


Tyr Val Leu His Cys Ile Leu Trp Gly Thr Asn Val Tyr Trp Val Ala 
            20                  25                  30          


Pro Val Glu Met Lys Arg Arg Asn Lys Ile Gln Pro Cys Leu Ser Lys 
        35                  40                  45              


Pro Ala Phe Ala Ser Leu Leu Arg Phe His Gln Phe His Pro Phe Leu 
    50                  55                  60                  


Cys Ala Ala Asp Phe Arg Lys Ile Ala Ser Leu Tyr Gly Ser Asp Lys 
65                  70                  75                  80  


Phe Asp Leu Pro Tyr Gly Met Arg Thr Ser Ala Glu Tyr Phe Arg Leu 
                85                  90                  95      


Ala Leu Ser Lys Leu Gln Ser Cys Asp Leu Phe Asp Glu Phe Asp Asn 
            100                 105                 110         


Ile Pro Cys Lys Lys Cys Val Val Val Gly Asn Gly Gly Val Leu Lys 
        115                 120                 125             


Asn Lys Thr Leu Gly Glu Lys Ile Asp Ser Tyr Asp Val Ile Ile Arg 
    130                 135                 140                 


Met Asn Asn Gly Pro Val Leu Gly His Glu Glu Glu Val Gly Arg Arg 
145                 150                 155                 160 


Thr Thr Phe Arg Leu Phe Tyr Pro Glu Ser Val Phe Ser Asp Pro Ile 
                165                 170                 175     


His Asn Asp Pro Asn Thr Thr Val Ile Leu Thr Ala Phe Lys Pro His 
            180                 185                 190         


Asp Leu Arg Trp Leu Leu Glu Leu Leu Met Gly Asp Lys Ile Asn Thr 
        195                 200                 205             


Asn Gly Phe Trp Lys Lys Pro Ala Leu Asn Leu Ile Tyr Lys Pro Tyr 
    210                 215                 220                 


Gln Ile Arg Ile Leu Asp Pro Phe Ile Ile Arg Thr Ala Ala Tyr Glu 
225                 230                 235                 240 


Leu Leu His Phe Pro Lys Val Phe Pro Lys Asn Gln Lys Pro Lys His 
                245                 250                 255     


Pro Thr Thr Gly Ile Ile Ala Ile Thr Leu Ala Phe Tyr Ile Cys His 
            260                 265                 270         


Glu Val His Leu Ala Gly Phe Lys Tyr Asn Phe Ser Asp Leu Lys Ser 
        275                 280                 285             


Pro Leu His Tyr Tyr Gly Asn Ala Thr Met Ser Leu Met Asn Lys Asn 
    290                 295                 300                 


Ala Tyr His Asn Val Thr Ala Glu Gln Leu Phe Leu Lys Asp Ile Ile 
305                 310                 315                 320 


Glu Lys Asn Leu Val Ile Asn Leu Thr Gln Asp 
                325                 330     


<210>  213
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Arg Thr Ser Ala Glu Tyr Phe Arg Leu Ala Leu Ser Lys Leu Gln 
1               5                   10                  15      


Ser Cys Asp Leu Phe Asp Glu Phe Asp Lys Met Asn Asn Gly Pro Val 
            20                  25                  30          


Leu Gly His Glu Glu Glu Val Gly Arg Arg Thr Thr Phe Arg Leu Phe 
        35                  40                  45              


Tyr Pro Glu Ser Val Phe Ser Asp Pro Ile His Asn Asp Pro Asn Thr 
    50                  55                  60                  


Thr Val Ile Leu Thr Ala Phe Lys Pro His Asp Leu Arg Trp Leu Leu 
65                  70                  75                  80  


Glu Leu Leu Met Gly Asp Lys Ile Asn Thr Asn Gly Phe Trp Lys Lys 
                85                  90                  95      


Pro Ala Leu Asn Leu Ile Tyr Lys Pro Tyr Gln Ile Arg Ile Leu Asp 
            100                 105                 110         


Pro Phe Ile Ile Arg Thr Ala Ala Tyr Glu Leu Leu His Phe Pro Lys 
        115                 120                 125             


Val Phe Pro Lys Asn Gln Lys Pro Lys His Pro Thr Thr Gly Ile Ile 
    130                 135                 140                 


Ala Ile Thr Leu Ala Phe Tyr Ile Cys His Glu Val His Leu Ala Gly 
145                 150                 155                 160 


Phe Lys Tyr Asn Phe Ser Asp Leu Lys Ser Pro Leu His Tyr Tyr Gly 
                165                 170                 175     


Asn Ala Thr Met Ser Leu Met Asn Lys Asn Ala Tyr His Asn Val Thr 
            180                 185                 190         


Ala Glu Gln Leu Phe Leu Lys Asp Ile Ile Glu Lys Asn Leu Val Ile 
        195                 200                 205             


Asn Leu Thr Gln Asp 
    210             


<210>  214
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Glu Glu Glu Asp Glu Glu Ala Arg Ala Leu Leu Ala Gly Gly Pro 
1               5                   10                  15      


Asp Glu Ala Asp Arg Gly Ala Pro Ala Ala Pro Gly Ala Leu Pro Ala 
            20                  25                  30          


Leu Cys Asp Pro Ser Arg Leu Ala His Arg Leu Leu Val Leu Leu Leu 
        35                  40                  45              


Met Cys Phe Leu Gly Phe Gly Ser Tyr Phe Cys Tyr Asp Asn Pro Ala 
    50                  55                  60                  


Ala Leu Gln Thr Gln Val Lys Arg Asp Met Gln Val Asn Thr Thr Lys 
65                  70                  75                  80  


Phe Met Leu Leu Tyr Ala Trp Tyr Ser Trp Pro Asn Val Val Leu Cys 
                85                  90                  95      


Phe Phe Gly Gly Phe Leu Ile Asp Arg Val Phe Gly Ile Arg Trp Gly 
            100                 105                 110         


Thr Ile Ile Phe Ser Cys Phe Val Cys Ile Gly Gln Val Val Phe Ala 
        115                 120                 125             


Leu Gly Gly Ile Phe Asn Ala Phe Trp Leu Met Glu Phe Gly Arg Phe 
    130                 135                 140                 


Val Phe Gly Ile Gly Gly Glu Ser Leu Ala Val Ala Gln Asn Thr Tyr 
145                 150                 155                 160 


Ala Val Ser Trp Phe Lys Gly Lys Glu Leu Asn Leu Val Phe Gly Leu 
                165                 170                 175     


Gln Leu Ser Met Ala Arg Ile Gly Ser Thr Val Asn Met Asn Leu Met 
            180                 185                 190         


Gly Trp Leu Tyr Ser Lys Ile Glu Ala Leu Leu Gly Ser Ala Gly His 
        195                 200                 205             


Thr Thr Leu Gly Ile Thr Leu Met Ile Gly Gly Ile Thr Cys Ile Leu 
    210                 215                 220                 


Ser Leu Ile Cys Ala Leu Ala Leu Ala Tyr Leu Asp Gln Arg Ala Glu 
225                 230                 235                 240 


Arg Ile Leu His Lys Glu Gln Gly Lys Thr Gly Glu Val Ile Lys Leu 
                245                 250                 255     


Thr Asp Val Lys Asp Phe Ser Leu Pro Leu Trp Leu Ile Phe Ile Ile 
            260                 265                 270         


Cys Val Cys Tyr Tyr Val Ala Val Phe Pro Phe Ile Gly Leu Gly Lys 
        275                 280                 285             


Val Phe Phe Thr Glu Lys Phe Gly Phe Ser Ser Gln Ala Ala Ser Ala 
    290                 295                 300                 


Ile Asn Ser Val Val Tyr Val Ile Ser Ala Pro Met Ser Pro Val Phe 
305                 310                 315                 320 


Gly Leu Leu Val Asp Lys Thr Gly Lys Asn Ile Ile Trp Val Leu Cys 
                325                 330                 335     


Ala Val Ala Ala Thr Leu Val Ser His Met Met Leu Ala Phe Thr Met 
            340                 345                 350         


Trp Asn Pro Trp Ile Ala Met Cys Leu Leu Gly Leu Ser Tyr Ser Leu 
        355                 360                 365             


Leu Ala Cys Ala Leu Trp Pro Met Val Ala Phe Val Val Pro Glu His 
    370                 375                 380                 


Gln Leu Gly Thr Ala Tyr Gly Phe Met Gln Ser Ile Gln Asn Leu Gly 
385                 390                 395                 400 


Leu Ala Ile Ile Ser Ile Ile Ala Gly Met Ile Leu Asp Ser Arg Gly 
                405                 410                 415     


Tyr Leu Phe Leu Glu Val Phe Phe Ile Ala Cys Val Ser Leu Ser Leu 
            420                 425                 430         


Leu Ser Val Val Leu Leu Tyr Leu Val Asn Arg Ala Gln Gly Gly Asn 
        435                 440                 445             


Leu Asn Tyr Ser Ala Arg Gln Arg Glu Glu Ile Lys Phe Ser His Thr 
    450                 455                 460                 


Glu 
465 


<210>  215
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Glu Glu Glu Asp Glu Glu Ala Arg Ala Leu Leu Ala Gly Gly Pro 
1               5                   10                  15      


Asp Glu Ala Asp Arg Gly Ala Pro Ala Ala Pro Gly Ala Leu Pro Ala 
            20                  25                  30          


Leu Cys Asp Pro Ser Arg Leu Ala His Arg Leu Leu Val Leu Leu Leu 
        35                  40                  45              


Met Cys Phe Leu Gly Phe Gly Ser Tyr Phe Cys Tyr Asp Asn Pro Ala 
    50                  55                  60                  


Ala Leu Gln Thr Gln Val Lys Arg Met Gly His Asn His Phe 
65                  70                  75              


<210>  216
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Glu Glu Glu Asp Glu Glu Ala Arg Ala Leu Leu Ala Gly Gly Pro 
1               5                   10                  15      


Asp Glu Ala Asp Arg Gly Ala Pro Ala Ala Pro Gly Ala Leu Pro Ala 
            20                  25                  30          


Leu Cys Asp Pro Ser Arg Leu Ala His Arg Leu Leu Val Leu Leu Leu 
        35                  40                  45              


Met Cys Phe Leu Gly Phe Ala Ile Phe Ala Met Ile Ile Leu Leu Pro 
    50                  55                  60                  


Phe Arg Leu Lys Leu Asp Glu Trp Gly Thr Ile Ile Phe Ser Cys Phe 
65                  70                  75                  80  


Val Cys Ile Gly Gln Val Val Phe Ala Leu Gly Gly Ile Phe Asn Ala 
                85                  90                  95      


Phe Trp Leu Met Glu Phe Gly Arg Phe Val Phe Gly Ile Gly Gly Glu 
            100                 105                 110         


Ser Leu Ala Val Ala Gln Asn Thr Tyr Ala Val Ser Trp Phe Lys Gly 
        115                 120                 125             


Lys Glu Leu Asn Leu Val Phe Gly Leu Gln Leu Ser Met Ala Arg Ile 
    130                 135                 140                 


Gly Ser Thr Val Asn Met Asn Leu Met Gly Trp Leu Tyr Ser Lys Ile 
145                 150                 155                 160 


Glu Ala Leu Leu Gly Ser Ala Gly His Thr Thr Leu Gly Ile Thr Leu 
                165                 170                 175     


Met Ile Gly Gly Ile Thr Cys Ile Leu Ser Leu Ile Cys Ala Leu Ala 
            180                 185                 190         


Leu Ala Tyr Leu Asp Gln Arg Ala Glu Arg Ile Leu His Lys Glu Gln 
        195                 200                 205             


Gly Lys Thr Gly Glu Val Ile Lys Leu Thr Asp Val Lys Asp Phe Ser 
    210                 215                 220                 


Leu Pro Leu Trp Leu Ile Phe Ile Ile Cys Val Cys Tyr Tyr Val Ala 
225                 230                 235                 240 


Val Phe Pro Phe Ile Gly Leu Gly Lys Val Phe Phe Thr Glu Lys Phe 
                245                 250                 255     


Gly Phe Ser Ser Gln Ala Ala Ser Ala Ile Asn Ser Val Val Tyr Val 
            260                 265                 270         


Ile Ser Ala Pro Met Ser Pro Val Phe Gly Leu Leu Val Asp Lys Thr 
        275                 280                 285             


Gly Lys Asn Ile Ile Trp Val Leu Cys Ala Val Ala Ala Thr Leu Val 
    290                 295                 300                 


Ser His Met Met Leu Ala Phe Thr Met Trp Asn Pro Trp Ile Ala Met 
305                 310                 315                 320 


Cys Leu Leu Gly Leu Ser Tyr Ser Leu Leu Ala Cys Ala Leu Trp Pro 
                325                 330                 335     


Met Val Ala Phe Val Val Pro Glu His Gln Leu Gly Thr Ala Tyr Gly 
            340                 345                 350         


Phe Met Gln Ser Ile Gln Asn Leu Gly Leu Ala Ile Ile Ser Ile Ile 
        355                 360                 365             


Ala Gly Met Ile Leu Asp Ser Arg Gly Tyr Leu Phe Leu Glu Val Phe 
    370                 375                 380                 


Phe Ile Ala Cys Val Ser Leu Ser Leu Leu Ser Val Val Leu Leu Tyr 
385                 390                 395                 400 


Leu Val Asn Arg Ala Gln Gly Gly Asn Leu Asn Tyr Ser Ala Arg Gln 
                405                 410                 415     


Arg Glu Glu Ile Lys Phe Ser His Thr Glu 
            420                 425     


<210>  217
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Gln Val Asn Thr Thr Lys Phe Met Leu Leu Tyr Ala Trp Tyr Ser 
1               5                   10                  15      


Trp Pro Asn Val Val Leu Cys Phe Phe Gly Gly Phe Leu Ile Asp Arg 
            20                  25                  30          


Val Phe Gly Ile Arg Trp Gly Thr Ile Ile Phe Ser Cys Phe Val Cys 
        35                  40                  45              


Ile Gly Gln Val Val Phe Ala Leu Gly Gly Ile Phe Asn Ala Phe Trp 
    50                  55                  60                  


Leu Met Glu Phe Gly Arg Phe Val Phe Gly Ile Gly Gly Glu Ser Leu 
65                  70                  75                  80  


Ala Val Ala Gln Asn Thr Tyr Ala Val Ser Trp Phe Lys Gly Lys Glu 
                85                  90                  95      


Leu Asn Leu Val Phe Gly Leu Gln Leu Ser Met Ala Arg Ile Gly Ser 
            100                 105                 110         


Thr Val Asn Met Asn Leu Met Gly Trp Leu Tyr Ser Lys Ile Glu Ala 
        115                 120                 125             


Leu Leu Gly Ser Ala Gly His Thr Thr Leu Gly Ile Thr Leu Met Ile 
    130                 135                 140                 


Gly Gly Ile Thr Cys Ile Leu Ser Leu Ile Cys Ala Leu Ala Leu Ala 
145                 150                 155                 160 


Tyr Leu Asp Gln Arg Ala Glu Arg Ile Leu His Lys Glu Gln Gly Lys 
                165                 170                 175     


Thr Gly Glu Val Ile Lys Leu Thr Asp Val Lys Asp Phe Ser Leu Pro 
            180                 185                 190         


Leu Trp Leu Ile Phe Ile Ile Cys Val Cys Tyr Tyr Val Ala Val Phe 
        195                 200                 205             


Pro Phe Ile Gly Leu Gly Lys Val Phe Phe Thr Glu Lys Phe Gly Phe 
    210                 215                 220                 


Ser Ser Gln Ala Ala Ser Ala Ile Asn Ser Val Val Tyr Val Ile Ser 
225                 230                 235                 240 


Ala Pro Met Ser Pro Val Phe Gly Leu Leu Val Asp Lys Thr Gly Lys 
                245                 250                 255     


Asn Ile Ile Trp Val Leu Cys Ala Val Ala Ala Thr Leu Val Ser His 
            260                 265                 270         


Met Met Leu Ala Phe Thr Met Trp Asn Pro Trp Ile Ala Met Cys Leu 
        275                 280                 285             


Leu Gly Leu Ser Tyr Ser Leu Leu Ala Cys Ala Leu Trp Pro Met Val 
    290                 295                 300                 


Ala Phe Val Val Pro Glu His Gln Leu Gly Thr Ala Tyr Gly Phe Met 
305                 310                 315                 320 


Gln Ser Ile Gln Asn Leu Gly Leu Ala Ile Ile Ser Ile Ile Ala Gly 
                325                 330                 335     


Met Ile Leu Asp Ser Arg Gly Tyr Leu Phe Leu Glu Val Phe Phe Ile 
            340                 345                 350         


Ala Cys Val Ser Leu Ser Leu Leu Ser Val Val Leu Leu Tyr Leu Val 
        355                 360                 365             


Asn Arg Ala Gln Gly Gly Asn Leu Asn Tyr Ser Ala Arg Gln Arg Glu 
    370                 375                 380                 


Glu Ile Lys Phe Ser His Thr Glu 
385                 390         


<210>  218
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Gly Val Ala Leu Arg Asp Leu Pro Gly Arg His Val Ser Ser Arg 
1               5                   10                  15      


Ser His Val Thr Ala Val Leu Thr Val Phe His Gly Arg Cys Phe Leu 
            20                  25                  30          


Pro Gly Phe Gly Val Val Thr Thr Phe Pro Ser Pro Ser Pro Ala Gly 
        35                  40                  45              


Ala Met Glu Glu Glu Asp Glu Glu Ala Arg Ala Leu Leu Ala Gly Gly 
    50                  55                  60                  


Pro Asp Glu Ala Asp Arg Gly Ala Pro Ala Ala Pro Gly Ala Leu Pro 
65                  70                  75                  80  


Ala Leu Cys Asp Pro Ser Arg Leu Ala His Arg Leu Leu Val Leu Leu 
                85                  90                  95      


Leu Met Cys Phe Leu Gly Phe Ala Ile Phe Ala Met Ile Ile Leu Leu 
            100                 105                 110         


Pro Phe Arg Leu Lys Leu Asn Glu Trp Gly Thr Ile Ile Phe Ser Cys 
        115                 120                 125             


Phe Val Cys Ile Gly Gln Val Val Phe Ala Leu Gly Gly Ile Phe Asn 
    130                 135                 140                 


Ala Phe Trp Leu Met Glu Phe Gly Arg Phe Val Phe Gly Ile Gly Gly 
145                 150                 155                 160 


Glu Ser Leu Ala Val Ala Gln Asn Thr Tyr Ala Val Ser Trp Phe Lys 
                165                 170                 175     


Gly Lys Glu Leu Asn Leu Val Phe Gly Leu Gln Leu Ser Met Ala Arg 
            180                 185                 190         


Ile Gly Ser Thr Val Asn Met Asn Leu Met Gly Trp Leu Tyr Ser Lys 
        195                 200                 205             


Ile Glu Ala Leu Leu Gly Ser Ala Gly His Thr Thr Leu Gly Ile Thr 
    210                 215                 220                 


Leu Met Ile Gly Gly Ile Thr Cys Ile Leu Ser Leu Ile Cys Ala Leu 
225                 230                 235                 240 


Ala Leu Ala Tyr Leu Asp Gln Arg Ala Glu Arg Ile Leu His Lys Glu 
                245                 250                 255     


Gln Gly Lys Thr Gly Glu Val Ile Lys Leu Thr Asp Val Lys Asp Phe 
            260                 265                 270         


Ser Leu Pro Leu Trp Leu Ile Phe Ile Ile Cys Val Cys Tyr Tyr Val 
        275                 280                 285             


Ala Val Phe Pro Phe Ile Gly Leu Gly Lys Val Phe Phe Thr Glu Lys 
    290                 295                 300                 


Phe Gly Phe Ser Ser Gln Ala Ala Ser Ala Ile Asn Ser Val Val Tyr 
305                 310                 315                 320 


Val Ile Ser Ala Pro Met Ser Pro Val Phe Gly Leu Leu Val Asp Lys 
                325                 330                 335     


Thr Gly Lys Asn Ile Ile Trp Val Leu Cys Ala Val Ala Ala Thr Leu 
            340                 345                 350         


Val Ser His Met Met Leu Ala Phe Thr Met Trp Asn Pro Trp Ile Ala 
        355                 360                 365             


Met Cys Leu Leu Gly Leu Ser Tyr Ser Leu Leu Ala Cys Ala Leu Trp 
    370                 375                 380                 


Pro Met Val Ala Phe Val Val Pro Glu His Gln Leu Gly Thr Ala Tyr 
385                 390                 395                 400 


Gly Phe Met Gln Ser Ile Gln Asn Leu Gly Leu Ala Ile Ile Ser Ile 
                405                 410                 415     


Ile Ala Gly Met Ile Leu Asp Ser Arg Gly Tyr Leu Phe Leu Glu Val 
            420                 425                 430         


Phe Phe Ile Ala Cys Val Ser Leu Ser Leu Leu Ser Val Val Leu Leu 
        435                 440                 445             


Tyr Leu Val Asn Arg Ala Gln Gly Gly Asn Leu Asn Tyr Ser Ala Arg 
    450                 455                 460                 


Gln Arg Glu Glu Ile Lys Phe Ser His Thr Glu 
465                 470                 475 


<210>  219
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Gly Val Ala Leu Arg Asp Leu Pro Gly Arg His Val Ser Ser Arg 
1               5                   10                  15      


Ser His Val Thr Ala Val Leu Thr Val Phe His Gly Arg Cys Phe Leu 
            20                  25                  30          


Pro Gly Phe Gly Val Val Thr Thr Phe Pro Ser Pro Ser Pro Ala Gly 
        35                  40                  45              


Ala Met Glu Glu Glu Asp Glu Glu Ala Arg Ala Leu Leu Ala Gly Gly 
    50                  55                  60                  


Pro Asp Glu Ala Asp Arg Gly Ala Pro Ala Ala Pro Gly Ala Leu Pro 
65                  70                  75                  80  


Ala Leu Cys Asp Pro Ser Arg Leu Ala His Arg Leu Leu Val Leu Leu 
                85                  90                  95      


Leu Met Cys Phe Leu Gly Phe Gly Ser Tyr Phe Cys Tyr Asp Asn Pro 
            100                 105                 110         


Ala Ala Leu Gln Thr Gln Val Lys Arg Asp Met Gln Val Asn Thr Thr 
        115                 120                 125             


Lys Phe Met Leu Leu Tyr Ala Trp Tyr Ser Trp Pro Asn Val Val Leu 
    130                 135                 140                 


Cys Phe Phe Gly Gly Phe Leu Ile Asp Arg Val Phe Gly Ile Arg Trp 
145                 150                 155                 160 


Gly Thr Ile Ile Phe Ser Cys Phe Val Cys Ile Gly Gln Val Val Phe 
                165                 170                 175     


Ala Leu Gly Gly Ile Phe Asn Ala Phe Trp Leu Met Glu Phe Gly Arg 
            180                 185                 190         


Phe Val Phe Gly Ile Gly Gly Glu Ser Leu Ala Val Ala Gln Asn Thr 
        195                 200                 205             


Tyr Ala Val Ser Trp Phe Lys Gly Lys Glu Leu Asn Leu Val Phe Gly 
    210                 215                 220                 


Leu Gln Leu Ser Met Ala Arg Ile Gly Ser Thr Val Asn Met Asn Leu 
225                 230                 235                 240 


Met Gly Trp Leu Tyr Ser Lys Ile Glu Ala Leu Leu Gly Ser Ala Gly 
                245                 250                 255     


His Thr Thr Leu Gly Ile Thr Leu Met Ile Gly Gly Ile Thr Cys Ile 
            260                 265                 270         


Leu Ser Leu Ile Cys Ala Leu Ala Leu Ala Tyr Leu Asp Gln Arg Ala 
        275                 280                 285             


Glu Arg Ile Leu His Lys Glu Gln Gly Lys Thr Gly Glu Val Ile Lys 
    290                 295                 300                 


Leu Thr Asp Val Lys Asp Phe Ser Leu Pro Leu Trp Leu Ile Phe Ile 
305                 310                 315                 320 


Ile Cys Val Cys Tyr Tyr Val Ala Val Phe Pro Phe Ile Gly Leu Gly 
                325                 330                 335     


Lys Val Phe Phe Thr Glu Lys Phe Gly Phe Ser Ser Gln Ala Ala Ser 
            340                 345                 350         


Ala Ile Asn Ser Val Val Tyr Val Ile Ser Ala Pro Met Ser Pro Val 
        355                 360                 365             


Phe Gly Leu Leu Val Asp Lys Thr Gly Lys Asn Ile Ile Trp Val Leu 
    370                 375                 380                 


Cys Ala Val Ala Ala Thr Leu Val Ser His Met Met Leu Ala Phe Thr 
385                 390                 395                 400 


Met Trp Asn Pro Trp Ile Ala Met Cys Leu Leu Gly Leu Ser Tyr Ser 
                405                 410                 415     


Leu Leu Ala Cys Ala Leu Trp Pro Met Val Ala Phe Val Val Pro Glu 
            420                 425                 430         


His Gln Leu Gly Thr Ala Tyr Gly Phe Met Gln Ser Ile Gln Asn Leu 
        435                 440                 445             


Gly Leu Ala Ile Ile Ser Ile Ile Ala Gly Met Ile Leu Asp Ser Arg 
    450                 455                 460                 


Gly Tyr Leu Phe Leu Glu Val Phe Phe Ile Ala Cys Val Ser Leu Ser 
465                 470                 475                 480 


Leu Leu Ser Val Val Leu Leu Tyr Leu Val Asn Arg Ala Gln Gly Gly 
                485                 490                 495     


Asn Leu Asn Tyr Ser Ala Arg Gln Arg Glu Glu Ile Lys Phe Ser His 
            500                 505                 510         


Thr Glu 
        


<210>  220
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Val Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Leu 
    690                 695                 700                 


Gly Lys Lys Asp Thr Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val 
705                 710                 715                 720 


Pro Asp Ala Val Glu Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp 
                725                 730                 735     


Gly Thr 
        


<210>  221
<211>  720
<212>  PRT
<213>  Homo sapiens

<400>  221

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Val Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Glu Pro Leu Asn Ser Asp Val Gln Tyr 
            660                 665                 670         


Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Leu Gly Lys 
        675                 680                 685             


Lys Asp Thr Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val Pro Asp 
    690                 695                 700                 


Ala Val Glu Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp Gly Thr 
705                 710                 715                 720 


<210>  222
<211>  717
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Val Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Asp Leu Gly Lys Lys Asp Thr 
        675                 680                 685             


Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val Pro Asp Ala Val Glu 
    690                 695                 700                 


Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp Gly Thr 
705                 710                 715         


<210>  223
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Val Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Ala 
    690                 695                 700                 


Val Glu Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp Gly Thr 
705                 710                 715                 


<210>  224
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Val Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Glu Asn 
    690                 695                 700                 


Gly Arg Leu Pro 
705             


<210>  225
<211>  727
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Val Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Leu 
    690                 695                 700                 


Gly Lys Lys Asp Thr Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val 
705                 710                 715                 720 


Pro Glu Asn Gly Arg Leu Pro 
                725         


<210>  226
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Ile Ser Leu Pro Gly Pro Leu Val Thr Asn Leu Leu Arg Phe Leu 
1               5                   10                  15      


Phe Leu Gly Leu Ser Ala Leu Ala Pro Pro Ser Arg Ala Gln Leu Gln 
            20                  25                  30          


Leu His Leu Pro Ala Asn Arg Leu Gln Ala Val Glu Gly Gly Glu Val 
        35                  40                  45              


Val Leu Pro Ala Trp Tyr Thr Leu His Gly Glu Val Ser Ser Ser Gln 
    50                  55                  60                  


Pro Trp Glu Val Pro Phe Val Met Trp Phe Phe Lys Gln Lys Glu Lys 
65                  70                  75                  80  


Glu Asp Gln Val Leu Ser Tyr Ile Asn Gly Val Thr Thr Ser Lys Pro 
                85                  90                  95      


Gly Val Ser Leu Val Tyr Ser Met Pro Ser Arg Asn Leu Ser Leu Arg 
            100                 105                 110         


Leu Glu Gly Leu Gln Glu Lys Asp Ser Gly Pro Tyr Ser Cys Ser Val 
        115                 120                 125             


Asn Val Gln Asp Lys Gln Gly Lys Ser Arg Gly His Ser Ile Lys Thr 
    130                 135                 140                 


Leu Glu Leu Asn Val Leu Val Pro Pro Ala Pro Pro Ser Cys Arg Leu 
145                 150                 155                 160 


Gln Gly Val Pro His Val Gly Ala Asn Val Thr Leu Ser Cys Gln Ser 
                165                 170                 175     


Pro Arg Ser Lys Pro Ala Val Gln Tyr Gln Trp Asp Arg Gln Leu Pro 
            180                 185                 190         


Ser Phe Gln Thr Phe Phe Ala Pro Ala Leu Asp Val Ile Arg Gly Ser 
        195                 200                 205             


Leu Ser Leu Thr Asn Leu Ser Ser Ser Met Ala Gly Val Tyr Val Cys 
    210                 215                 220                 


Lys Ala His Asn Glu Val Gly Thr Ala Gln Cys Asn Val Thr Leu Glu 
225                 230                 235                 240 


Val Ser Thr Gly Pro Gly Ala Ala Val Val Ala Gly Ala Val Val Gly 
                245                 250                 255     


Thr Leu Val Gly Leu Gly Leu Leu Ala Gly Leu Val Leu Leu Tyr His 
            260                 265                 270         


Arg Arg Gly Lys Ala Leu Glu Glu Pro Ala Asn Asp Ile Lys Glu Asp 
        275                 280                 285             


Ala Ile Ala Pro Arg Thr Leu Pro Trp Pro Lys Ser Ser Asp Thr Ile 
    290                 295                 300                 


Ser Lys Asn Gly Thr Leu Ser Ser Val Thr Ser Ala Arg Ala Leu Arg 
305                 310                 315                 320 


Pro Pro His Gly Pro Pro Arg Pro Gly Ala Leu Thr Pro Thr Pro Ser 
                325                 330                 335     


Leu Ser Ser Gln Ala Leu Pro Ser Pro Arg Leu Pro Thr Thr Asp Gly 
            340                 345                 350         


Ala His Pro Gln Pro Ile Ser Pro Ile Pro Gly Gly Val Ser Ser Ser 
        355                 360                 365             


Gly Leu Ser Arg Met Gly Ala Val Pro Val Met Val Pro Ala Gln Ser 
    370                 375                 380                 


Gln Ala Gly Ser Leu Val 
385                 390 


<210>  227
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  227

Met Ile Ser Leu Pro Gly Pro Leu Val Thr Asn Leu Leu Arg Phe Leu 
1               5                   10                  15      


Phe Leu Gly Leu Ser Ala Leu Asp Val Ile Arg Gly Ser Leu Ser Leu 
            20                  25                  30          


Thr Asn Leu Ser Ser Ser Met Ala Gly Val Tyr Val Cys Lys Ala His 
        35                  40                  45              


Asn Glu Val Gly Thr Ala Gln Cys Asn Val Thr Leu Glu Val Ser Thr 
    50                  55                  60                  


Gly Pro Gly Ala Ala Val Val Ala Gly Ala Val Val Gly Thr Leu Val 
65                  70                  75                  80  


Gly Leu Gly Leu Leu Ala Gly Leu Val Leu Leu Tyr His Arg Arg Gly 
                85                  90                  95      


Lys Ala Leu Glu Glu Pro Ala Asn Asp Ile Lys Val Arg Ser Pro Leu 
            100                 105                 110         


Gly Leu Ser Phe Ser Ala Pro Lys Met Glu Trp Leu Trp Lys Trp Arg 
        115                 120                 125             


Asp Ala His Phe Tyr Arg Asp Ser Tyr Leu Ser Lys Trp 
    130                 135                 140     


<210>  228
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Lys Leu Leu Lys Leu Thr Gly Phe Ile Phe Phe Leu Phe Phe Leu 
1               5                   10                  15      


Thr Glu Ser Leu Thr Leu Pro Thr Gln Pro Arg Asp Ile Glu Asn Phe 
            20                  25                  30          


Asn Ser Thr Gln Lys Phe Ile Glu Asp Asn Ile Glu Tyr Ile Thr Ile 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Val Gln Glu Ala Thr Phe Glu Glu Met Glu 
    50                  55                  60                  


Lys Leu Val Lys Asp Met Val Glu Tyr Lys Asp Arg Cys Met Ala Asp 
65                  70                  75                  80  


Lys Thr Leu Pro Glu Cys Ser Lys Leu Pro Asn Asn Val Leu Gln Glu 
                85                  90                  95      


Lys Ile Cys Ala Met Glu Gly Leu Pro Gln Lys His Asn Phe Ser His 
            100                 105                 110         


Cys Cys Ser Lys Val Asp Ala Gln Arg Arg Leu Cys Phe Phe Tyr Asn 
        115                 120                 125             


Lys Lys Ser Asp Val Gly Phe Leu Pro Pro Phe Pro Thr Leu Asp Pro 
    130                 135                 140                 


Glu Glu Lys Cys Gln Ala Tyr Glu Ser Asn Arg Glu Ser Leu Leu Asn 
145                 150                 155                 160 


His Phe Leu Tyr Glu Val Ala Arg Arg Asn Pro Phe Val Phe Ala Pro 
                165                 170                 175     


Thr Leu Leu Thr Val Ala Val His Phe Glu Glu Val Ala Lys Ser Cys 
            180                 185                 190         


Cys Glu Glu Gln Asn Lys Val Asn Cys Leu Gln Thr Arg Ala Ile Pro 
        195                 200                 205             


Val Thr Gln Tyr Leu Lys Ala Phe Ser Ser Tyr Gln Lys His Val Cys 
    210                 215                 220                 


Gly Ala Leu Leu Lys Phe Gly Thr Lys Val Val His Phe Ile Tyr Ile 
225                 230                 235                 240 


Ala Ile Leu Ser Gln Lys Phe Pro Lys Ile Glu Phe Lys Glu Leu Ile 
                245                 250                 255     


Ser Leu Val Glu Asp Val Ser Ser Asn Tyr Asp Gly Cys Cys Glu Gly 
            260                 265                 270         


Asp Val Val Gln Cys Ile Arg Asp Thr Ser Lys Val Met Asn His Ile 
        275                 280                 285             


Cys Ser Lys Gln Asp Ser Ile Ser Ser Lys Ile Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Lys Ile Pro Glu Arg Gly Gln Cys Ile Ile Asn Ser Asn Lys Asp 
305                 310                 315                 320 


Asp Arg Pro Lys Asp Leu Ser Leu Arg Glu Gly Lys Phe Thr Asp Ser 
                325                 330                 335     


Glu Asn Val Cys Gln Glu Arg Asp Ala Asp Pro Asp Thr Phe Phe Ala 
            340                 345                 350         


Lys Phe Thr Phe Glu Tyr Ser Arg Arg His Pro Asp Leu Ser Ile Pro 
        355                 360                 365             


Glu Leu Leu Arg Ile Val Gln Ile Tyr Lys Asp Leu Leu Arg Asn Cys 
    370                 375                 380                 


Cys Asn Thr Glu Asn Pro Pro Gly Cys Tyr Arg Tyr Ala Glu Asp Lys 
385                 390                 395                 400 


Phe Asn Glu Thr Thr Glu Lys Ser Leu Lys Met Val Gln Gln Glu Cys 
                405                 410                 415     


Lys His Phe Gln Asn Leu Gly Lys Asp Gly Leu Lys Tyr His Tyr Leu 
            420                 425                 430         


Ile Arg Leu Thr Lys Ile Ala Pro Gln Leu Ser Thr Glu Glu Leu Val 
        435                 440                 445             


Ser Leu Gly Glu Lys Met Val Thr Ala Phe Thr Thr Cys Cys Thr Leu 
    450                 455                 460                 


Ser Glu Glu Phe Ala Cys Val Asp Asn Leu Ala Asp Leu Val Phe Gly 
465                 470                 475                 480 


Glu Leu Cys Gly Val Asn Glu Asn Arg Thr Ile Asn Pro Ala Val Asp 
                485                 490                 495     


His Cys Cys Lys Thr Asn Phe Ala Phe Arg Arg Pro Cys Phe Glu Ser 
            500                 505                 510         


Leu Lys Ala Asp Lys Thr Tyr Val Pro Pro Pro Phe Ser Gln Asp Leu 
        515                 520                 525             


Phe Thr Phe His Ala Asp Met Cys Gln Ser Gln Asn Glu Glu Leu Gln 
    530                 535                 540                 


Arg Lys Thr Asp Arg Phe Leu Val Asn Leu Val Lys Leu Lys His Glu 
545                 550                 555                 560 


Leu Thr Asp Glu Glu Leu Gln Ser Leu Phe Thr Asn Phe Ala Asn Val 
                565                 570                 575     


Val Asp Lys Cys Cys Lys Ala Glu Ser Pro Glu Val Cys Phe Asn Glu 
            580                 585                 590         


Glu Ser Pro Lys Ile Gly Asn 
        595                 


<210>  229
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  229

Met Asn Lys Pro Leu Leu Trp Ile Ser Val Leu Thr Ser Leu Leu Glu 
1               5                   10                  15      


Ala Phe Ala His Thr Asp Leu Ser Gly Lys Val Phe Val Phe Pro Arg 
            20                  25                  30          


Glu Ser Val Thr Asp His Val Asn Leu Ile Thr Pro Leu Glu Lys Pro 
        35                  40                  45              


Leu Gln Asn Phe Thr Leu Cys Phe Arg Ala Tyr Ser Asp Leu Ser Arg 
    50                  55                  60                  


Ala Tyr Ser Leu Phe Ser Tyr Asn Thr Gln Gly Arg Asp Asn Glu Leu 
65                  70                  75                  80  


Leu Val Tyr Lys Glu Arg Val Gly Glu Tyr Ser Leu Tyr Ile Gly Arg 
                85                  90                  95      


His Lys Val Thr Ser Lys Val Ile Glu Lys Phe Pro Ala Pro Val His 
            100                 105                 110         


Ile Cys Val Ser Trp Glu Ser Ser Ser Gly Ile Ala Glu Phe Trp Ile 
        115                 120                 125             


Asn Gly Thr Pro Leu Val Lys Lys Gly Leu Arg Gln Gly Tyr Phe Val 
    130                 135                 140                 


Glu Ala Gln Pro Lys Ile Val Leu Gly Gln Glu Gln Asp Ser Tyr Gly 
145                 150                 155                 160 


Gly Lys Phe Asp Arg Ser Gln Ser Phe Val Gly Glu Ile Gly Asp Leu 
                165                 170                 175     


Tyr Met Trp Asp Ser Val Leu Pro Pro Glu Asn Ile Leu Ser Ala Tyr 
            180                 185                 190         


Gln Gly Thr Pro Leu Pro Ala Asn Ile Leu Asp Trp Gln Ala Leu Asn 
        195                 200                 205             


Tyr Glu Ile Arg Gly Tyr Val Ile Ile Lys Pro Leu Val Trp Val 
    210                 215                 220             


<210>  230
<211>  615
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Arg Ala Leu Leu Leu Leu Gly Phe Leu Leu Val Ser Leu Glu Ser 
1               5                   10                  15      


Thr Leu Ser Ile Pro Pro Trp Glu Ala Pro Lys Glu His Lys Tyr Lys 
            20                  25                  30          


Ala Glu Glu His Thr Val Val Leu Thr Val Thr Gly Glu Pro Cys His 
        35                  40                  45              


Phe Pro Phe Gln Tyr His Arg Gln Leu Tyr His Lys Cys Thr His Lys 
    50                  55                  60                  


Gly Arg Pro Gly Pro Gln Pro Trp Cys Ala Thr Thr Pro Asn Phe Asp 
65                  70                  75                  80  


Gln Asp Gln Arg Trp Gly Tyr Cys Leu Glu Pro Lys Lys Val Lys Asp 
                85                  90                  95      


His Cys Ser Lys His Ser Pro Cys Gln Lys Gly Gly Thr Cys Val Asn 
            100                 105                 110         


Met Pro Ser Gly Pro His Cys Leu Cys Pro Gln His Leu Thr Gly Asn 
        115                 120                 125             


His Cys Gln Lys Glu Lys Cys Phe Glu Pro Gln Leu Leu Arg Phe Phe 
    130                 135                 140                 


His Lys Asn Glu Ile Trp Tyr Arg Thr Glu Gln Ala Ala Val Ala Arg 
145                 150                 155                 160 


Cys Gln Cys Lys Gly Pro Asp Ala His Cys Gln Arg Leu Ala Ser Gln 
                165                 170                 175     


Ala Cys Arg Thr Asn Pro Cys Leu His Gly Gly Arg Cys Leu Glu Val 
            180                 185                 190         


Glu Gly His Arg Leu Cys His Cys Pro Val Gly Tyr Thr Gly Ala Phe 
        195                 200                 205             


Cys Asp Val Asp Thr Lys Ala Ser Cys Tyr Asp Gly Arg Gly Leu Ser 
    210                 215                 220                 


Tyr Arg Gly Leu Ala Arg Thr Thr Leu Ser Gly Ala Pro Cys Gln Pro 
225                 230                 235                 240 


Trp Ala Ser Glu Ala Thr Tyr Arg Asn Val Thr Ala Glu Gln Ala Arg 
                245                 250                 255     


Asn Trp Gly Leu Gly Gly His Ala Phe Cys Arg Asn Pro Asp Asn Asp 
            260                 265                 270         


Ile Arg Pro Trp Cys Phe Val Leu Asn Arg Asp Arg Leu Ser Trp Glu 
        275                 280                 285             


Tyr Cys Asp Leu Ala Gln Cys Gln Thr Pro Thr Gln Ala Ala Pro Pro 
    290                 295                 300                 


Thr Pro Val Ser Pro Arg Leu His Val Pro Leu Met Pro Ala Gln Pro 
305                 310                 315                 320 


Ala Pro Pro Lys Pro Gln Pro Thr Thr Arg Thr Pro Pro Gln Ser Gln 
                325                 330                 335     


Thr Pro Gly Ala Leu Pro Ala Lys Arg Glu Gln Pro Pro Ser Leu Thr 
            340                 345                 350         


Arg Asn Gly Pro Leu Ser Cys Gly Gln Arg Leu Arg Lys Ser Leu Ser 
        355                 360                 365             


Ser Met Thr Arg Val Val Gly Gly Leu Val Ala Leu Arg Gly Ala His 
    370                 375                 380                 


Pro Tyr Ile Ala Ala Leu Tyr Trp Gly His Ser Phe Cys Ala Gly Ser 
385                 390                 395                 400 


Leu Ile Ala Pro Cys Trp Val Leu Thr Ala Ala His Cys Leu Gln Asp 
                405                 410                 415     


Arg Pro Ala Pro Glu Asp Leu Thr Val Val Leu Gly Gln Glu Arg Arg 
            420                 425                 430         


Asn His Ser Cys Glu Pro Cys Gln Thr Leu Ala Val Arg Ser Tyr Arg 
        435                 440                 445             


Leu His Glu Ala Phe Ser Pro Val Ser Tyr Gln His Asp Leu Ala Leu 
    450                 455                 460                 


Leu Arg Leu Gln Glu Asp Ala Asp Gly Ser Cys Ala Leu Leu Ser Pro 
465                 470                 475                 480 


Tyr Val Gln Pro Val Cys Leu Pro Ser Gly Ala Ala Arg Pro Ser Glu 
                485                 490                 495     


Thr Thr Leu Cys Gln Val Ala Gly Trp Gly His Gln Phe Glu Gly Ala 
            500                 505                 510         


Glu Glu Tyr Ala Ser Phe Leu Gln Glu Ala Gln Val Pro Phe Leu Ser 
        515                 520                 525             


Leu Glu Arg Cys Ser Ala Pro Asp Val His Gly Ser Ser Ile Leu Pro 
    530                 535                 540                 


Gly Met Leu Cys Ala Gly Phe Leu Glu Gly Gly Thr Asp Ala Cys Gln 
545                 550                 555                 560 


Gly Asp Ser Gly Gly Pro Leu Val Cys Glu Asp Gln Ala Ala Glu Arg 
                565                 570                 575     


Arg Leu Thr Leu Gln Gly Ile Ile Ser Trp Gly Ser Gly Cys Gly Asp 
            580                 585                 590         


Arg Asn Lys Pro Gly Val Tyr Thr Asp Val Ala Tyr Tyr Leu Ala Trp 
        595                 600                 605             


Ile Arg Glu His Thr Val Ser 
    610                 615 


<210>  231
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  231

Met Ala Tyr Pro Gly Tyr Gly Gly Gly Phe Gly Asn Phe Ser Ile Gln 
1               5                   10                  15      


Val Pro Gly Met Gln Met Gly Gln Pro Val Pro Glu Thr Gly Pro Ala 
            20                  25                  30          


Ile Leu Leu Asp Gly Tyr Ser Gly Pro Ala Tyr Ser Asp Thr Tyr Ser 
        35                  40                  45              


Ser Ala Gly Asp Ser Val Tyr Thr Tyr Phe Ser Ala Val Ala Gly Gln 
    50                  55                  60                  


Asp Gly Glu Val Asp Ala Glu Glu Leu Gln Arg Cys Leu Thr Gln Ser 
65                  70                  75                  80  


Gly Ile Asn Gly Thr Tyr Ser Pro Phe Ser Leu Glu Thr Cys Arg Ile 
                85                  90                  95      


Met Ile Ala Met Leu Asp Arg Asp His Thr Gly Lys Met Gly Phe Asn 
            100                 105                 110         


Ala Phe Lys Glu Leu Trp Ala Ala Leu Asn Ala Trp Lys Glu Asn Phe 
        115                 120                 125             


Met Thr Val Asp Gln Asp Gly Ser Gly Thr Val Glu His His Glu Leu 
    130                 135                 140                 


Arg Gln Ala Ile Gly Leu Met Gly Tyr Arg Leu Ser Pro Gln Thr Leu 
145                 150                 155                 160 


Thr Thr Ile Val Lys Arg Tyr Ser Lys Asn Gly Arg Ile Phe Phe Asp 
                165                 170                 175     


Asp Tyr Val Ala Cys Cys Val Lys Leu Arg Ala Leu Thr Asp Phe Phe 
            180                 185                 190         


Arg Lys Arg Asp His Leu Gln Gln Gly Ser Ala Asn Phe Ile Tyr Asp 
        195                 200                 205             


Asp Phe Leu Gln Gly Thr Met Ala Ile 
    210                 215         


<210>  232
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Ala Ala Arg Arg Ala Leu His Phe Val Phe Lys Val Gly Asn Arg 
1               5                   10                  15      


Phe Gln Thr Ala Arg Phe Tyr Arg Asp Val Leu Gly Met Lys Val Glu 
            20                  25                  30          


Ser Cys Ser Val Ala Arg Leu Glu Cys Ser Gly Ala Ile Ser Ala His 
        35                  40                  45              


Cys Ser Asp Tyr Thr Arg Ile Thr Glu Asp Ser Phe Ser Lys Pro Tyr 
    50                  55                  60                  


Asp Gly Lys Trp Ser Lys Thr Met Val Gly Phe Gly Pro Glu Asp Asp 
65                  70                  75                  80  


His Phe Val Ala Glu Leu Thr Tyr Asn Tyr Gly Val Gly Asp Tyr Lys 
                85                  90                  95      


Leu Gly Asn Asp Phe Met Gly Ile Thr Leu Ala Ser Ser Gln Ala Val 
            100                 105                 110         


Ser Asn Ala Arg Lys Leu Glu Trp Pro Leu Thr Glu Val Ala Glu Gly 
        115                 120                 125             


Val Phe Glu Thr Glu Ala Pro Gly Gly Tyr Lys Phe Tyr Leu Gln Asn 
    130                 135                 140                 


Arg Ser Leu Pro Gln Ser Asp Pro Val Leu Lys Val Thr Leu Ala Val 
145                 150                 155                 160 


Ser Asp Leu Gln Lys Ser Leu Asn Tyr Trp Cys Asn Leu Leu Gly Met 
                165                 170                 175     


Lys Ile Tyr Glu Lys Asp Glu Glu Lys Gln Arg Ala Leu Leu Gly Tyr 
            180                 185                 190         


Ala Asp Asn Gln Cys Lys Leu Glu Leu Gln Gly Val Lys Gly Gly Val 
        195                 200                 205             


Asp His Ala Ala Ala Phe Gly Arg Ile Ala Phe Ser Cys Pro Gln Lys 
    210                 215                 220                 


Glu Leu Pro Asp Leu Glu Asp Leu Met Lys Arg Glu Asn Gln Lys Ile 
225                 230                 235                 240 


Leu Thr Pro Leu Val Ser Leu Asp Thr Pro Gly Lys Ala Thr Val Gln 
                245                 250                 255     


Val Val Ile Leu Ala Asp Pro Asp Gly His Glu Ile Cys Phe Val Gly 
            260                 265                 270         


Asp Glu Ala Phe Arg Glu Leu Ser Lys Met Asp Pro Glu Gly Ser Lys 
        275                 280                 285             


Leu Leu Asp Asp Ala Met Ala Ala Asp Lys Ser Asp Glu Trp Phe Ala 
    290                 295                 300                 


Lys His Asn Lys Pro Lys Ala Ser Gly 
305                 310             


<210>  233
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  233

Met Ala Ala Arg Arg Ala Leu His Phe Val Phe Lys Val Gly Asn Arg 
1               5                   10                  15      


Phe Gln Thr Ala Arg Phe Tyr Arg Asp Val Leu Gly Met Lys Val Leu 
            20                  25                  30          


Arg His Glu Glu Phe Glu Glu Gly Cys Lys Ala Ala Cys Asn Gly Pro 
        35                  40                  45              


Tyr Asp Gly Lys Trp Ser Lys Thr Met Val Gly Phe Gly Pro Glu Asp 
    50                  55                  60                  


Asp His Phe Val Ala Glu Leu Thr Tyr Asn Tyr Gly Val Gly Asp Tyr 
65                  70                  75                  80  


Lys Leu Gly Asn Asp Phe Met Gly Ile Thr Leu Ala Ser Ser Gln Ala 
                85                  90                  95      


Val Ser Asn Ala Arg Lys Leu Glu Trp Pro Leu Thr Glu Val Ala Glu 
            100                 105                 110         


Gly Val Phe Glu Thr Glu Ala Pro Gly Gly Tyr Lys Phe Tyr Leu Gln 
        115                 120                 125             


Asn Arg Ser Leu Pro Gln Ser Asp Pro Val Leu Lys Val Thr Leu Ala 
    130                 135                 140                 


Val Ser Asp Leu Gln Lys Ser Leu Asn Tyr Trp Cys Asn Leu Leu Gly 
145                 150                 155                 160 


Met Lys Ile Tyr Glu Lys Asp Glu Glu Lys Gln Arg Ala Leu Leu Gly 
                165                 170                 175     


Tyr Ala Asp Asn Gln Cys Lys Leu Glu Leu Gln Gly Val Lys Gly Gly 
            180                 185                 190         


Val Asp His Ala Ala Ala Phe Gly Arg Ile Ala Phe Ser Cys Pro Gln 
        195                 200                 205             


Lys Glu Leu Pro Asp Leu Glu Asp Leu Met Lys Arg Glu Asn Gln Lys 
    210                 215                 220                 


Ile Leu Thr Pro Leu Val Ser Leu Asp Thr Pro Gly Lys Ala Thr Val 
225                 230                 235                 240 


Gln Val Val Ile Leu Ala Asp Pro Asp Gly His Glu Ile Cys Phe Val 
                245                 250                 255     


Gly Asp Glu Ala Phe Arg Glu Leu Ser Lys Met Asp Pro Glu Gly Ser 
            260                 265                 270         


Lys Leu Leu Asp Asp Ala Met Ala Ala Asp Lys Ser Asp Glu Trp Phe 
        275                 280                 285             


Ala Lys His Asn Lys Pro Lys Ala Ser Gly 
    290                 295             


<210>  234
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Ala Ala Arg Arg Ala Leu His Phe Val Phe Lys Val Gly Asn Arg 
1               5                   10                  15      


Phe Gln Thr Ala Arg Phe Tyr Arg Asp Val Leu Gly Met Lys Val Leu 
            20                  25                  30          


Arg His Glu Glu Phe Glu Glu Gly Cys Lys Ala Ala Cys Asn Gly Pro 
        35                  40                  45              


Tyr Asp Gly Lys Trp Ser Lys Thr Met Val Gly Phe Gly Pro Glu Asp 
    50                  55                  60                  


Asp His Phe Val Ala Glu Leu Thr Tyr Asn Tyr Gly Val Gly Asp Tyr 
65                  70                  75                  80  


Lys Leu Gly Asn Asp Phe Met Gly Ile Thr Leu Ala Ser Ser Gln Ala 
                85                  90                  95      


Val Ser Asn Ala Arg Lys Leu Glu Trp Pro Leu Thr Glu Val Ala Glu 
            100                 105                 110         


Gly Val Phe Glu Thr Glu Ala Pro Gly Gly Tyr Lys Phe Tyr Leu Gln 
        115                 120                 125             


Asn Arg Ser Leu Pro Gln Ser Asp Pro Val Leu Lys Val Thr Leu Ala 
    130                 135                 140                 


Val Ser Asp Leu Gln Lys Ser Leu Asn Tyr Trp Cys Asn Leu Leu Gly 
145                 150                 155                 160 


Met Lys Ile Tyr Glu Lys Asp Glu Glu Lys Gln Arg Ala Leu Leu Gly 
                165                 170                 175     


Tyr Ala Asp Asn Gln Val Ser Asn Leu Gly Glu Glu 
            180                 185             


<210>  235
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Leu Arg Gly Thr Leu Leu Cys Ala Val Leu Gly Leu Leu Arg Ala 
1               5                   10                  15      


Gln Pro Phe Pro Cys Pro Pro Ala Cys Lys Cys Val Phe Arg Asp Ala 
            20                  25                  30          


Ala Gln Cys Ser Gly Gly Asp Val Ala Arg Ile Ser Ala Leu Gly Leu 
        35                  40                  45              


Pro Thr Asn Leu Thr His Ile Leu Leu Phe Gly Met Gly Arg Gly Val 
    50                  55                  60                  


Leu Gln Ser Gln Ser Phe Ser Gly Met Thr Val Leu Gln Arg Leu Met 
65                  70                  75                  80  


Ile Ser Asp Ser His Ile Ser Ala Val Ala Pro Gly Thr Phe Ser Asp 
                85                  90                  95      


Leu Ile Lys Leu Lys Thr Leu Arg Leu Ser Arg Asn Lys Ile Thr His 
            100                 105                 110         


Leu Pro Gly Ala Leu Leu Asp Lys Met Val Leu Leu Glu Gln Leu Phe 
        115                 120                 125             


Leu Asp His Asn Ala Leu Arg Gly Ile Asp Gln Asn Met Phe Gln Lys 
    130                 135                 140                 


Leu Val Asn Leu Gln Glu Leu Ala Leu Asn Gln Asn Gln Leu Asp Phe 
145                 150                 155                 160 


Leu Pro Ala Ser Leu Phe Thr Asn Leu Glu Asn Leu Lys Leu Leu Asp 
                165                 170                 175     


Leu Ser Gly Asn Asn Leu Thr His Leu Pro Lys Gly Leu Leu Gly Ala 
            180                 185                 190         


Gln Ala Lys Leu Glu Arg Leu Leu Leu His Ser Asn Arg Leu Val Ser 
        195                 200                 205             


Leu Asp Ser Gly Leu Leu Asn Ser Leu Gly Ala Leu Thr Glu Leu Gln 
    210                 215                 220                 


Phe His Arg Asn His Ile Arg Ser Ile Ala Pro Gly Ala Phe Asp Arg 
225                 230                 235                 240 


Leu Pro Asn Leu Ser Ser Leu Thr Leu Ser Arg Asn His Leu Ala Phe 
                245                 250                 255     


Leu Pro Ser Ala Leu Phe Leu His Ser His Asn Leu Thr Leu Leu Thr 
            260                 265                 270         


Leu Phe Glu Asn Pro Leu Ala Glu Leu Pro Gly Val Leu Phe Gly Glu 
        275                 280                 285             


Met Gly Gly Leu Gln Glu Leu Trp Leu Asn Arg Thr Gln Leu Arg Thr 
    290                 295                 300                 


Leu Pro Ala Ala Ala Phe Arg Asn Leu Ser Arg Leu Arg Tyr Leu Gly 
305                 310                 315                 320 


Val Thr Leu Ser Pro Arg Leu Ser Ala Leu Pro Gln Gly Ala Phe Gln 
                325                 330                 335     


Gly Leu Gly Glu Leu Gln Val Leu Ala Leu His Ser Asn Gly Leu Thr 
            340                 345                 350         


Ala Leu Pro Asp Gly Leu Leu Arg Gly Leu Gly Lys Leu Arg Gln Val 
        355                 360                 365             


Ser Leu Arg Arg Asn Arg Leu Arg Ala Leu Pro Arg Ala Leu Phe Arg 
    370                 375                 380                 


Asn Leu Ser Ser Leu Glu Ser Val Gln Leu Asp His Asn Gln Leu Glu 
385                 390                 395                 400 


Thr Leu Pro Gly Asp Val Phe Gly Ala Leu Pro Arg Leu Thr Glu Val 
                405                 410                 415     


Leu Leu Gly His Asn Ser Trp Arg Cys Asp Cys Gly Leu Gly Pro Phe 
            420                 425                 430         


Leu Gly Trp Leu Arg Gln His Leu Gly Leu Val Gly Gly Glu Glu Pro 
        435                 440                 445             


Pro Arg Cys Ala Gly Pro Gly Ala His Ala Gly Leu Pro Leu Trp Ala 
    450                 455                 460                 


Leu Pro Gly Gly Asp Ala Glu Cys Pro Gly Pro Arg Gly Pro Pro Pro 
465                 470                 475                 480 


Arg Pro Ala Ala Asp Ser Ser Ser Glu Ala Pro Val His Pro Ala Leu 
                485                 490                 495     


Ala Pro Asn Ser Ser Glu Pro Trp Val Trp Ala Gln Pro Val Thr Thr 
            500                 505                 510         


Gly Lys Gly Gln Asp His Ser Pro Phe Trp Gly Phe Tyr Phe Leu Leu 
        515                 520                 525             


Leu Ala Val Gln Ala Met Ile Thr Val Ile Ile Val Phe Ala Met Ile 
    530                 535                 540                 


Lys Ile Gly Gln Leu Phe Arg Lys Leu Ile Arg Glu Arg Ala Leu Gly 
545                 550                 555                 560 


<210>  236
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Gly Arg Trp Ala Trp Val Pro Ser Pro Trp Pro Pro Pro Gly Leu 
1               5                   10                  15      


Gly Pro Phe Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Pro Arg Gly 
            20                  25                  30          


Phe Gln Pro Gln Pro Gly Gly Asn Arg Thr Glu Ser Pro Glu Pro Asn 
        35                  40                  45              


Ala Thr Ala Thr Pro Ala Ile Pro Thr Ile Leu Val Thr Ser Val Thr 
    50                  55                  60                  


Ser Glu Thr Pro Ala Thr Ser Ala Pro Glu Ala Glu Gly Pro Gln Ser 
65                  70                  75                  80  


Gly Gly Leu Pro Pro Pro Pro Arg Ala Val Pro Ser Ser Ser Ser Pro 
                85                  90                  95      


Gln Ala Gln Ala Leu Thr Glu Asp Gly Arg Pro Cys Arg Phe Pro Phe 
            100                 105                 110         


Arg Tyr Gly Gly Arg Met Leu His Ala Cys Thr Ser Glu Gly Ser Ala 
        115                 120                 125             


His Arg Lys Trp Cys Ala Thr Thr His Asn Tyr Asp Arg Asp Arg Ala 
    130                 135                 140                 


Trp Gly Tyr Cys Val Glu Ala Thr Pro Pro Pro Gly Gly Pro Ala Ala 
145                 150                 155                 160 


Leu Asp Pro Cys Ala Ser Gly Pro Cys Leu Asn Gly Gly Ser Cys Ser 
                165                 170                 175     


Asn Thr Gln Asp Pro Gln Ser Tyr His Cys Ser Cys Pro Arg Ala Phe 
            180                 185                 190         


Thr Gly Lys Asp Cys Gly Thr Glu Lys Cys Phe Asp Glu Thr Arg Tyr 
        195                 200                 205             


Glu Tyr Leu Glu Gly Gly Asp Arg Trp Ala Arg Val Arg Gln Gly His 
    210                 215                 220                 


Val Glu Gln Cys Glu Cys Phe Gly Gly Arg Thr Trp Cys Glu Gly Thr 
225                 230                 235                 240 


Arg His Thr Ala Cys Leu Ser Ser Pro Cys Leu Asn Gly Gly Thr Cys 
                245                 250                 255     


His Leu Ile Val Ala Thr Gly Thr Thr Val Cys Ala Cys Pro Pro Gly 
            260                 265                 270         


Phe Ala Gly Arg Leu Cys Asn Ile Glu Pro Asp Glu Arg Cys Phe Leu 
        275                 280                 285             


Gly Asn Gly Thr Gly Tyr Arg Gly Val Ala Ser Thr Ser Ala Ser Gly 
    290                 295                 300                 


Leu Ser Cys Leu Ala Trp Asn Ser Asp Leu Leu Tyr Gln Glu Leu His 
305                 310                 315                 320 


Val Asp Ser Val Gly Ala Ala Ala Leu Leu Gly Leu Gly Pro His Ala 
                325                 330                 335     


Tyr Cys Arg Asn Pro Asp Asn Asp Glu Arg Pro Trp Cys Tyr Val Val 
            340                 345                 350         


Lys Asp Ser Ala Leu Ser Trp Glu Tyr Cys Arg Leu Glu Ala Cys Glu 
        355                 360                 365             


Ser Leu Thr Arg Val Gln Leu Ser Pro Asp Leu Leu Ala Thr Leu Pro 
    370                 375                 380                 


Glu Pro Ala Ser Pro Gly Arg Gln Ala Cys Gly Arg Arg His Lys Lys 
385                 390                 395                 400 


Arg Thr Phe Leu Arg Pro Arg Ile Ile Gly Gly Ser Ser Ser Leu Pro 
                405                 410                 415     


Gly Ser His Pro Trp Leu Ala Ala Ile Tyr Ile Gly Asp Ser Phe Cys 
            420                 425                 430         


Ala Gly Ser Leu Val His Thr Cys Trp Val Val Ser Ala Ala His Cys 
        435                 440                 445             


Phe Ser His Ser Pro Pro Arg Asp Ser Val Ser Val Val Leu Gly Gln 
    450                 455                 460                 


His Phe Phe Asn Arg Thr Thr Asp Val Thr Gln Thr Phe Gly Ile Glu 
465                 470                 475                 480 


Lys Tyr Ile Pro Tyr Thr Leu Tyr Ser Val Phe Asn Pro Ser Asp His 
                485                 490                 495     


Asp Leu Val Leu Ile Arg Leu Lys Lys Lys Gly Asp Arg Cys Ala Thr 
            500                 505                 510         


Arg Ser Gln Phe Val Gln Pro Ile Cys Leu Pro Glu Pro Gly Ser Thr 
        515                 520                 525             


Phe Pro Ala Gly His Lys Cys Gln Ile Ala Gly Trp Gly His Leu Asp 
    530                 535                 540                 


Glu Asn Val Ser Gly Tyr Ser Ser Ser Leu Arg Glu Ala Leu Val Pro 
545                 550                 555                 560 


Leu Val Ala Asp His Lys Cys Ser Ser Pro Glu Val Tyr Gly Ala Asp 
                565                 570                 575     


Ile Ser Pro Asn Met Leu Cys Ala Gly Tyr Phe Asp Cys Lys Ser Asp 
            580                 585                 590         


Ala Cys Gln Gly Asp Ser Gly Gly Pro Leu Ala Cys Glu Lys Asn Gly 
        595                 600                 605             


Val Ala Tyr Leu Tyr Gly Ile Ile Ser Trp Gly Asp Gly Cys Gly Arg 
    610                 615                 620                 


Leu His Lys Pro Gly Val Tyr Thr Arg Val Ala Asn Tyr Val Asp Trp 
625                 630                 635                 640 


Ile Asn Asp Arg Ile Arg Pro Pro Arg Arg Leu Val Ala Pro Ser 
                645                 650                 655 


<210>  237
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 
    130                 135                 140                 


Lys Ser Gln Arg Arg Lys Gly Trp Pro Lys Thr His Pro Gly Gly Glu 
145                 150                 155                 160 


Gln Lys Glu Gly Thr Glu Ala Ser Leu Gln Ile Arg Gly Lys Lys Lys 
                165                 170                 175     


Glu Gln Arg Arg Glu Ile Gly Ser Arg Asn Ala Glu Cys Arg Gly Lys 
            180                 185                 190         


Lys Gly Lys 
        195 


<210>  238
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  238

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 
    130                 135                 140                 


Ser Ala Gly Asn Lys Asn Tyr Arg Met 
145                 150             


<210>  239
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  239

Met Ile Thr Pro Thr Val Lys Met His Thr Met Ser Ser Ser His Leu 
1               5                   10                  15      


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
            20                  25                  30          


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
        35                  40                  45              


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
    50                  55                  60                  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
65                  70                  75                  80  


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
                85                  90                  95      


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
            100                 105                 110         


Met Pro Lys Thr Gln Lys Glu Val His Leu Lys Asn Ala Ser Arg Gly 
        115                 120                 125             


Ser Ala Gly Asn Lys Asn Tyr Arg Met 
    130                 135         


<210>  240
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Gly Lys Ile Ser Ser Leu Pro Thr Gln Leu Phe Lys Cys Cys Phe 
1               5                   10                  15      


Cys Asp Phe Leu Lys Val Lys Met His Thr Met Ser Ser Ser His Leu 
            20                  25                  30          


Phe Tyr Leu Ala Leu Cys Leu Leu Thr Phe Thr Ser Ser Ala Thr Ala 
        35                  40                  45              


Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
    50                  55                  60                  


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
65                  70                  75                  80  


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
                85                  90                  95      


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
            100                 105                 110         


Lys Pro Ala Lys Ser Ala Arg Ser Val Arg Ala Gln Arg His Thr Asp 
        115                 120                 125             


Met Pro Lys Thr Gln Lys Tyr Gln Pro Pro Ser Thr Asn Lys Asn Thr 
    130                 135                 140                 


Lys Ser Gln Arg Arg Lys Gly Ser Thr Phe Glu Glu Arg Lys 
145                 150                 155             


<210>  241
<211>  949
<212>  PRT
<213>  Homo sapiens

<400>  241

Met Ile Leu Ser Leu Leu Phe Ser Leu Gly Gly Pro Leu Gly Trp Gly 
1               5                   10                  15      


Leu Leu Gly Ala Trp Ala Gln Ala Ser Ser Thr Ser Leu Ser Asp Leu 
            20                  25                  30          


Gln Ser Ser Arg Thr Pro Gly Val Trp Lys Ala Glu Ala Glu Asp Thr 
        35                  40                  45              


Gly Lys Asp Pro Val Gly Arg Asn Trp Cys Pro Tyr Pro Met Ser Lys 
    50                  55                  60                  


Leu Val Thr Leu Leu Ala Leu Cys Lys Thr Glu Lys Phe Leu Ile His 
65                  70                  75                  80  


Ser Gln Gln Pro Cys Pro Gln Gly Ala Pro Asp Cys Gln Lys Val Lys 
                85                  90                  95      


Val Met Tyr Arg Met Ala His Lys Pro Val Tyr Gln Val Lys Gln Lys 
            100                 105                 110         


Val Leu Thr Ser Leu Ala Trp Arg Cys Cys Pro Gly Tyr Thr Gly Pro 
        115                 120                 125             


Asn Cys Glu His His Asp Ser Met Ala Ile Pro Glu Pro Ala Asp Pro 
    130                 135                 140                 


Gly Asp Ser His Gln Glu Pro Gln Asp Gly Pro Val Ser Phe Lys Pro 
145                 150                 155                 160 


Gly His Leu Ala Ala Val Ile Asn Glu Val Glu Val Gln Gln Glu Gln 
                165                 170                 175     


Gln Glu His Leu Leu Gly Asp Leu Gln Asn Asp Val His Arg Val Ala 
            180                 185                 190         


Asp Ser Leu Pro Gly Leu Trp Lys Ala Leu Pro Gly Asn Leu Thr Ala 
        195                 200                 205             


Ala Val Met Glu Ala Asn Gln Thr Gly His Glu Phe Pro Asp Arg Ser 
    210                 215                 220                 


Leu Glu Gln Val Leu Leu Pro His Val Asp Thr Phe Leu Gln Val His 
225                 230                 235                 240 


Phe Ser Pro Ile Trp Arg Ser Phe Asn Gln Ser Leu His Ser Leu Thr 
                245                 250                 255     


Gln Ala Ile Arg Asn Leu Ser Leu Asp Val Glu Ala Asn Arg Gln Ala 
            260                 265                 270         


Ile Ser Arg Val Gln Asp Ser Ala Val Ala Arg Ala Asp Phe Gln Glu 
        275                 280                 285             


Leu Gly Ala Lys Phe Glu Ala Lys Val Gln Glu Asn Thr Gln Arg Val 
    290                 295                 300                 


Gly Gln Leu Arg Gln Asp Val Glu Asp Arg Leu His Ala Gln His Phe 
305                 310                 315                 320 


Thr Leu His Arg Ser Ile Ser Glu Leu Gln Ala Asp Val Asp Thr Lys 
                325                 330                 335     


Leu Lys Arg Leu His Lys Ala Gln Glu Ala Pro Gly Thr Asn Gly Ser 
            340                 345                 350         


Leu Val Leu Ala Thr Pro Gly Ala Gly Ala Arg Pro Glu Pro Asp Ser 
        355                 360                 365             


Leu Gln Ala Arg Leu Gly Gln Leu Gln Arg Asn Leu Ser Glu Leu His 
    370                 375                 380                 


Met Thr Thr Ala Arg Arg Glu Glu Glu Leu Gln Tyr Thr Leu Glu Asp 
385                 390                 395                 400 


Met Arg Ala Thr Leu Thr Arg His Val Asp Glu Ile Lys Glu Leu Tyr 
                405                 410                 415     


Ser Glu Ser Asp Glu Thr Phe Asp Gln Ile Ser Lys Val Glu Arg Gln 
            420                 425                 430         


Val Glu Glu Leu Gln Val Asn His Thr Ala Leu Arg Glu Leu Arg Val 
        435                 440                 445             


Ile Leu Met Glu Lys Ser Leu Ile Met Glu Glu Asn Lys Glu Glu Val 
    450                 455                 460                 


Glu Arg Gln Leu Leu Glu Leu Asn Leu Thr Leu Gln His Leu Gln Gly 
465                 470                 475                 480 


Gly His Ala Asp Leu Ile Lys Tyr Val Lys Asp Cys Asn Cys Gln Lys 
                485                 490                 495     


Leu Tyr Leu Asp Leu Asp Val Ile Arg Glu Gly Gln Arg Asp Ala Thr 
            500                 505                 510         


Arg Ala Leu Glu Glu Thr Gln Val Ser Leu Asp Glu Arg Arg Gln Leu 
        515                 520                 525             


Asp Gly Ser Ser Leu Gln Ala Leu Gln Asn Ala Val Asp Ala Val Ser 
    530                 535                 540                 


Leu Ala Val Asp Ala His Lys Ala Glu Gly Glu Arg Ala Arg Ala Ala 
545                 550                 555                 560 


Thr Ser Arg Leu Arg Ser Gln Val Gln Ala Leu Asp Asp Glu Val Gly 
                565                 570                 575     


Ala Leu Lys Ala Ala Ala Ala Glu Ala Arg His Glu Val Arg Gln Leu 
            580                 585                 590         


His Ser Ala Phe Ala Ala Leu Leu Glu Asp Ala Leu Arg His Glu Ala 
        595                 600                 605             


Val Leu Ala Ala Leu Phe Gly Glu Glu Val Leu Glu Glu Met Ser Glu 
    610                 615                 620                 


Gln Thr Pro Gly Pro Leu Pro Leu Ser Tyr Glu Gln Ile Arg Val Ala 
625                 630                 635                 640 


Leu Gln Asp Ala Ala Ser Gly Leu Gln Glu Gln Ala Leu Gly Trp Asp 
                645                 650                 655     


Glu Leu Ala Ala Arg Val Thr Ala Leu Glu Gln Ala Ser Glu Pro Pro 
            660                 665                 670         


Arg Pro Ala Glu His Leu Glu Pro Ser His Asp Ala Gly Arg Glu Glu 
        675                 680                 685             


Ala Ala Thr Thr Ala Leu Ala Gly Leu Ala Arg Glu Leu Gln Ser Leu 
    690                 695                 700                 


Ser Asn Asp Val Lys Asn Val Gly Arg Cys Cys Glu Ala Glu Ala Gly 
705                 710                 715                 720 


Ala Gly Ala Ala Ser Leu Asn Ala Ser Leu His Gly Leu His Asn Ala 
                725                 730                 735     


Leu Phe Ala Thr Gln Arg Ser Leu Glu Gln His Gln Arg Leu Phe His 
            740                 745                 750         


Ser Leu Phe Gly Asn Phe Gln Gly Leu Met Glu Ala Asn Val Ser Leu 
        755                 760                 765             


Asp Leu Gly Lys Leu Gln Thr Met Leu Ser Arg Lys Gly Lys Lys Gln 
    770                 775                 780                 


Gln Lys Asp Leu Glu Ala Pro Arg Lys Arg Asp Lys Lys Glu Ala Glu 
785                 790                 795                 800 


Pro Leu Val Asp Ile Arg Val Thr Gly Pro Val Pro Gly Ala Leu Gly 
                805                 810                 815     


Ala Ala Leu Trp Glu Ala Gly Ser Pro Val Ala Phe Tyr Ala Ser Phe 
            820                 825                 830         


Ser Glu Gly Thr Ala Ala Leu Gln Thr Val Lys Phe Asn Thr Thr Tyr 
        835                 840                 845             


Ile Asn Ile Gly Ser Ser Tyr Phe Pro Glu His Gly Tyr Phe Arg Ala 
    850                 855                 860                 


Pro Glu Arg Gly Val Tyr Leu Phe Ala Val Ser Val Glu Phe Gly Pro 
865                 870                 875                 880 


Gly Pro Gly Thr Gly Gln Leu Val Phe Gly Gly His His Arg Thr Pro 
                885                 890                 895     


Val Cys Thr Thr Gly Gln Gly Ser Gly Ser Thr Ala Thr Val Phe Ala 
            900                 905                 910         


Met Ala Glu Leu Gln Lys Gly Glu Arg Val Trp Phe Glu Leu Thr Gln 
        915                 920                 925             


Gly Ser Ile Thr Lys Arg Ser Leu Ser Gly Thr Ala Phe Gly Gly Phe 
    930                 935                 940                 


Leu Met Phe Lys Thr 
945                 


<210>  242
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Ser Ser Ala Ala Arg Ser Arg Leu Thr Arg Ala Thr Arg Gln Glu 
1               5                   10                  15      


Met Leu Phe Leu Ala Leu Leu Leu Leu Pro Val Val Val Ala Phe Ala 
            20                  25                  30          


Arg Ala Glu Ala Glu Glu Asp Gly Asp Leu Gln Cys Leu Cys Val Lys 
        35                  40                  45              


Thr Thr Ser Gln Val Arg Pro Arg His Ile Thr Ser Leu Glu Val Ile 
    50                  55                  60                  


Lys Ala Gly Pro His Cys Pro Thr Ala Gln Leu Ile Ala Thr Leu Lys 
65                  70                  75                  80  


Asn Gly Arg Lys Ile Cys Leu Asp Leu Gln Ala Leu Leu Tyr Lys Lys 
                85                  90                  95      


Ile Ile Lys Glu His Leu Glu Ser 
            100                 


<210>  243
<211>  780
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Ala Ala Val Asp Leu Glu Lys Leu Arg Ala Ser Gly Ala Gly Lys 
1               5                   10                  15      


Ala Ile Gly Val Leu Thr Ser Gly Gly Asp Ala Gln Gly Met Asn Ala 
            20                  25                  30          


Ala Val Arg Ala Val Thr Arg Met Gly Ile Tyr Val Gly Ala Lys Val 
        35                  40                  45              


Phe Leu Ile Tyr Glu Gly Tyr Glu Gly Leu Val Glu Gly Gly Glu Asn 
    50                  55                  60                  


Ile Lys Gln Ala Asn Trp Leu Ser Val Ser Asn Ile Ile Gln Leu Gly 
65                  70                  75                  80  


Gly Thr Ile Ile Gly Ser Ala Arg Cys Lys Ala Phe Thr Thr Arg Glu 
                85                  90                  95      


Gly Arg Arg Ala Ala Ala Tyr Asn Leu Val Gln His Gly Ile Thr Asn 
            100                 105                 110         


Leu Cys Val Ile Gly Gly Asp Gly Ser Leu Thr Gly Ala Asn Ile Phe 
        115                 120                 125             


Arg Ser Glu Trp Gly Ser Leu Leu Glu Glu Leu Val Ala Glu Gly Lys 
    130                 135                 140                 


Ile Ser Glu Thr Thr Ala Arg Thr Tyr Ser His Leu Asn Ile Ala Gly 
145                 150                 155                 160 


Leu Val Gly Ser Ile Asp Asn Asp Phe Cys Gly Thr Asp Met Thr Ile 
                165                 170                 175     


Gly Thr Asp Ser Ala Leu His Arg Ile Met Glu Val Ile Asp Ala Ile 
            180                 185                 190         


Thr Thr Thr Ala Gln Ser His Gln Arg Thr Phe Val Leu Glu Val Met 
        195                 200                 205             


Gly Arg His Cys Gly Tyr Leu Ala Leu Val Ser Ala Leu Ala Ser Gly 
    210                 215                 220                 


Ala Asp Trp Leu Phe Ile Pro Glu Ala Pro Pro Glu Asp Gly Trp Glu 
225                 230                 235                 240 


Asn Phe Met Cys Glu Arg Leu Gly Glu Thr Arg Ser Arg Gly Ser Arg 
                245                 250                 255     


Leu Asn Ile Ile Ile Ile Ala Glu Gly Ala Ile Asp Arg Asn Gly Lys 
            260                 265                 270         


Pro Ile Ser Ser Ser Tyr Val Lys Asp Leu Val Val Gln Arg Leu Gly 
        275                 280                 285             


Phe Asp Thr Arg Val Thr Val Leu Gly His Val Gln Arg Gly Gly Thr 
    290                 295                 300                 


Pro Ser Ala Phe Asp Arg Ile Leu Ser Ser Lys Met Gly Met Glu Ala 
305                 310                 315                 320 


Val Met Ala Leu Leu Glu Ala Thr Pro Asp Thr Pro Ala Cys Val Val 
                325                 330                 335     


Thr Leu Ser Gly Asn Gln Ser Val Arg Leu Pro Leu Met Glu Cys Val 
            340                 345                 350         


Gln Met Thr Lys Glu Val Gln Lys Ala Met Asp Asp Lys Arg Phe Asp 
        355                 360                 365             


Glu Ala Thr Gln Leu Arg Gly Gly Ser Phe Glu Asn Asn Trp Asn Ile 
    370                 375                 380                 


Tyr Lys Leu Leu Ala His Gln Lys Pro Pro Lys Glu Lys Ser Asn Phe 
385                 390                 395                 400 


Ser Leu Ala Ile Leu Asn Val Gly Ala Pro Ala Ala Gly Met Asn Ala 
                405                 410                 415     


Ala Val Arg Ser Ala Val Arg Thr Gly Ile Ser His Gly His Thr Val 
            420                 425                 430         


Tyr Val Val His Asp Gly Phe Glu Gly Leu Ala Lys Gly Gln Val Gln 
        435                 440                 445             


Glu Val Gly Trp His Asp Val Ala Gly Trp Leu Gly Arg Gly Gly Ser 
    450                 455                 460                 


Met Leu Gly Thr Lys Arg Thr Leu Pro Lys Gly Gln Leu Glu Ser Ile 
465                 470                 475                 480 


Val Glu Asn Ile Arg Ile Tyr Gly Ile His Ala Leu Leu Val Val Gly 
                485                 490                 495     


Gly Phe Glu Ala Tyr Glu Gly Val Leu Gln Leu Val Glu Ala Arg Gly 
            500                 505                 510         


Arg Tyr Glu Glu Leu Cys Ile Val Met Cys Val Ile Pro Ala Thr Ile 
        515                 520                 525             


Ser Asn Asn Val Pro Gly Thr Asp Phe Ser Leu Gly Ser Asp Thr Ala 
    530                 535                 540                 


Val Asn Ala Ala Met Glu Ser Cys Asp Arg Ile Lys Gln Ser Ala Ser 
545                 550                 555                 560 


Gly Thr Lys Arg Arg Val Phe Ile Val Glu Thr Met Gly Gly Tyr Cys 
                565                 570                 575     


Gly Tyr Leu Ala Thr Val Thr Gly Ile Ala Val Gly Ala Asp Ala Ala 
            580                 585                 590         


Tyr Val Phe Glu Asp Pro Phe Asn Ile His Asp Leu Lys Val Asn Val 
        595                 600                 605             


Glu His Met Thr Glu Lys Met Lys Thr Asp Ile Gln Arg Gly Leu Val 
    610                 615                 620                 


Leu Arg Asn Glu Lys Cys His Asp Tyr Tyr Thr Thr Glu Phe Leu Tyr 
625                 630                 635                 640 


Asn Leu Tyr Ser Ser Glu Gly Lys Gly Val Phe Asp Cys Arg Thr Asn 
                645                 650                 655     


Val Leu Gly His Leu Gln Gln Gly Gly Ala Pro Thr Pro Phe Asp Arg 
            660                 665                 670         


Asn Tyr Gly Thr Lys Leu Gly Val Lys Ala Met Leu Trp Leu Ser Glu 
        675                 680                 685             


Lys Leu Arg Glu Val Tyr Arg Lys Gly Arg Val Phe Ala Asn Ala Pro 
    690                 695                 700                 


Asp Ser Ala Cys Val Ile Gly Leu Lys Lys Lys Ala Val Ala Phe Ser 
705                 710                 715                 720 


Pro Val Thr Glu Leu Lys Lys Asp Thr Asp Phe Glu His Arg Met Pro 
                725                 730                 735     


Arg Glu Gln Trp Trp Leu Ser Leu Arg Leu Met Leu Lys Met Leu Ala 
            740                 745                 750         


Gln Tyr Arg Ile Ser Met Ala Ala Tyr Val Ser Gly Glu Leu Glu His 
        755                 760                 765             


Val Thr Arg Arg Thr Leu Ser Met Asp Lys Gly Phe 
    770                 775                 780 


<210>  244
<211>  827
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Cys Asn Gln Gly Arg Gly Arg Glu Ser Ser Arg Gly Gly Leu His 
1               5                   10                  15      


Val Gln Gly Ser Cys Arg Gly Leu Ser Arg Ser Pro Gln Gln Glu Thr 
            20                  25                  30          


Gly Phe Ala Lys Ala Pro Ala Gly Thr Asp Cys Phe Phe His Cys Ser 
        35                  40                  45              


Pro Gly Ser Arg Gly Gln Gly Asp Arg Lys Glu Glu Val Thr Ser Glu 
    50                  55                  60                  


Pro Gly Gly Thr Ser Ile Met Ser Arg Leu Gly Gly Met Asn Ala Ala 
65                  70                  75                  80  


Val Arg Ala Val Thr Arg Met Gly Ile Tyr Val Gly Ala Lys Val Phe 
                85                  90                  95      


Leu Ile Tyr Glu Gly Tyr Glu Gly Leu Val Glu Gly Gly Glu Asn Ile 
            100                 105                 110         


Lys Gln Ala Asn Trp Leu Ser Val Ser Asn Ile Ile Gln Leu Gly Gly 
        115                 120                 125             


Thr Ile Ile Gly Ser Ala Arg Cys Lys Ala Phe Thr Thr Arg Glu Gly 
    130                 135                 140                 


Arg Arg Ala Ala Ala Tyr Asn Leu Val Gln His Gly Ile Thr Asn Leu 
145                 150                 155                 160 


Cys Val Ile Gly Gly Asp Gly Ser Leu Thr Gly Ala Asn Ile Phe Arg 
                165                 170                 175     


Ser Glu Trp Gly Ser Leu Leu Glu Glu Leu Val Ala Glu Gly Lys Ile 
            180                 185                 190         


Ser Glu Thr Thr Ala Arg Thr Tyr Ser His Leu Asn Ile Ala Gly Leu 
        195                 200                 205             


Val Gly Ser Ile Asp Asn Asp Phe Cys Gly Thr Asp Met Thr Ile Gly 
    210                 215                 220                 


Thr Asp Ser Ala Leu His Arg Ile Met Glu Val Ile Asp Ala Ile Thr 
225                 230                 235                 240 


Thr Thr Ala Gln Ser His Gln Arg Thr Phe Val Leu Glu Val Met Gly 
                245                 250                 255     


Arg His Cys Gly Tyr Leu Ala Leu Val Ser Ala Leu Ala Ser Gly Ala 
            260                 265                 270         


Asp Trp Leu Phe Ile Pro Glu Ala Pro Pro Glu Asp Gly Trp Glu Asn 
        275                 280                 285             


Phe Met Cys Glu Arg Leu Gly Glu Thr Arg Ser Arg Gly Ser Arg Leu 
    290                 295                 300                 


Asn Ile Ile Ile Ile Ala Glu Gly Ala Ile Asp Arg Asn Gly Lys Pro 
305                 310                 315                 320 


Ile Ser Ser Ser Tyr Val Lys Asp Leu Val Val Gln Arg Leu Gly Phe 
                325                 330                 335     


Asp Thr Arg Val Thr Val Leu Gly His Val Gln Arg Gly Gly Thr Pro 
            340                 345                 350         


Ser Ala Phe Asp Arg Ile Leu Ser Ser Lys Met Gly Met Glu Ala Val 
        355                 360                 365             


Met Ala Leu Leu Glu Ala Thr Pro Asp Thr Pro Ala Cys Val Val Thr 
    370                 375                 380                 


Leu Ser Gly Asn Gln Ser Val Arg Leu Pro Leu Met Glu Cys Val Gln 
385                 390                 395                 400 


Met Thr Lys Glu Val Gln Lys Ala Met Asp Asp Lys Arg Phe Asp Glu 
                405                 410                 415     


Ala Thr Gln Leu Arg Gly Gly Ser Phe Glu Asn Asn Trp Asn Ile Tyr 
            420                 425                 430         


Lys Leu Leu Ala His Gln Lys Pro Pro Lys Glu Lys Ser Asn Phe Ser 
        435                 440                 445             


Leu Ala Ile Leu Asn Val Gly Ala Pro Ala Ala Gly Met Asn Ala Ala 
    450                 455                 460                 


Val Arg Ser Ala Val Arg Thr Gly Ile Ser His Gly His Thr Val Tyr 
465                 470                 475                 480 


Val Val His Asp Gly Phe Glu Gly Leu Ala Lys Gly Gln Val Gln Glu 
                485                 490                 495     


Val Gly Trp His Asp Val Ala Gly Trp Leu Gly Arg Gly Gly Ser Met 
            500                 505                 510         


Leu Gly Thr Lys Arg Thr Leu Pro Lys Gly Gln Leu Glu Ser Ile Val 
        515                 520                 525             


Glu Asn Ile Arg Ile Tyr Gly Ile His Ala Leu Leu Val Val Gly Gly 
    530                 535                 540                 


Phe Glu Ala Tyr Glu Gly Val Leu Gln Leu Val Glu Ala Arg Gly Arg 
545                 550                 555                 560 


Tyr Glu Glu Leu Cys Ile Val Met Cys Val Ile Pro Ala Thr Ile Ser 
                565                 570                 575     


Asn Asn Val Pro Gly Thr Asp Phe Ser Leu Gly Ser Asp Thr Ala Val 
            580                 585                 590         


Asn Ala Ala Met Glu Ser Cys Asp Arg Ile Lys Gln Ser Ala Ser Gly 
        595                 600                 605             


Thr Lys Arg Arg Val Phe Ile Val Glu Thr Met Gly Gly Tyr Cys Gly 
    610                 615                 620                 


Tyr Leu Ala Thr Val Thr Gly Ile Ala Val Gly Ala Asp Ala Ala Tyr 
625                 630                 635                 640 


Val Phe Glu Asp Pro Phe Asn Ile His Asp Leu Lys Val Asn Val Glu 
                645                 650                 655     


His Met Thr Glu Lys Met Lys Thr Asp Ile Gln Arg Gly Leu Val Leu 
            660                 665                 670         


Arg Asn Glu Lys Cys His Asp Tyr Tyr Thr Thr Glu Phe Leu Tyr Asn 
        675                 680                 685             


Leu Tyr Ser Ser Glu Gly Lys Gly Val Phe Asp Cys Arg Thr Asn Val 
    690                 695                 700                 


Leu Gly His Leu Gln Gln Gly Gly Ala Pro Thr Pro Phe Asp Arg Asn 
705                 710                 715                 720 


Tyr Gly Thr Lys Leu Gly Val Lys Ala Met Leu Trp Leu Ser Glu Lys 
                725                 730                 735     


Leu Arg Glu Val Tyr Arg Lys Gly Arg Val Phe Ala Asn Ala Pro Asp 
            740                 745                 750         


Ser Ala Cys Val Ile Gly Leu Lys Lys Lys Ala Val Ala Phe Ser Pro 
        755                 760                 765             


Val Thr Glu Leu Lys Lys Asp Thr Asp Phe Glu His Arg Met Pro Arg 
    770                 775                 780                 


Glu Gln Trp Trp Leu Ser Leu Arg Leu Met Leu Lys Met Leu Ala Gln 
785                 790                 795                 800 


Tyr Arg Ile Ser Met Ala Ala Tyr Val Ser Gly Glu Leu Glu His Val 
                805                 810                 815     


Thr Arg Arg Thr Leu Ser Met Asp Lys Gly Phe 
            820                 825         


<210>  245
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  245

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Thr Thr Lys 
            660                 665                 670         


Ile Ile Thr Lys Val Val Glu Pro Lys Ile Lys Val Ile Glu Gly Ser 
        675                 680                 685             


Leu Gln Pro Ile Ile Lys Thr Glu Gly Pro Thr Leu Thr Lys Val Lys 
    690                 695                 700                 


Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys Glu Gly Glu Thr Ile 
705                 710                 715                 720 


Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys Lys Tyr Thr Lys Ile 
                725                 730                 735     


Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys Glu Thr Arg Glu Glu 
            740                 745                 750         


Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr Arg Ile Ser Thr Gly 
        755                 760                 765             


Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu Leu Gln Glu Glu Val 
    770                 775                 780                 


Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp Gly His Leu Phe Glu 
785                 790                 795                 800 


Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp Thr Pro Val Arg Lys 
                805                 810                 815     


Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu 
            820                 825                 830         


Gly Arg Ser Gln 
        835     


<210>  246
<211>  779
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Lys Pro Ile 
            660                 665                 670         


Ile Lys Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr 
        675                 680                 685             


Glu Lys Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys 
    690                 695                 700                 


Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys 
705                 710                 715                 720 


Lys Leu Leu Gln Glu Glu Val Thr Lys Val Thr Lys Phe Ile Glu Gly 
                725                 730                 735     


Gly Asp Gly His Leu Phe Glu Asp Glu Glu Ile Lys Arg Leu Leu Gln 
            740                 745                 750         


Gly Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys Val Gln Gly 
        755                 760                 765             


Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
    770                 775                 


<210>  247
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  247

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Arg Pro Thr 
            660                 665                 670         


Leu Thr Lys Val Lys Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys 
        675                 680                 685             


Glu Gly Glu Thr Ile Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys 
    690                 695                 700                 


Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys 
705                 710                 715                 720 


Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr 
                725                 730                 735     


Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu 
            740                 745                 750         


Leu Gln Glu Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys Val 
        755                 760                 765             


Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
    770                 775                 780     


<210>  248
<211>  751
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Lys Pro Ile 
            660                 665                 670         


Ile Lys Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr 
        675                 680                 685             


Glu Lys Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys 
    690                 695                 700                 


Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys 
705                 710                 715                 720 


Lys Leu Leu Gln Glu Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys 
                725                 730                 735     


Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
            740                 745                 750     


<210>  249
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  249

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Arg Pro Thr 
            660                 665                 670         


Leu Thr Lys Val Lys Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys 
        675                 680                 685             


Glu Gly Glu Thr Ile Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys 
    690                 695                 700                 


Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys 
705                 710                 715                 720 


Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr 
                725                 730                 735     


Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu 
            740                 745                 750         


Leu Gln Glu Glu Val Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp 
        755                 760                 765             


Gly His Leu Phe Glu Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp 
    770                 775                 780                 


Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg 
785                 790                 795                 800 


Arg Arg Leu Arg Glu Gly Arg Ser Gln 
                805                 


<210>  250
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Ser Pro Glu 
            660                 665                 670         


Ile Lys Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr 
        675                 680                 685             


Leu Lys Lys Leu Leu Gln Glu Glu Val Thr Lys Val Thr Lys Phe Ile 
    690                 695                 700                 


Glu Gly Gly Asp Gly His Leu Phe Glu Asp Glu Glu Ile Lys Arg Leu 
705                 710                 715                 720 


Leu Gln Gly Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys Val 
                725                 730                 735     


Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
            740                 745                 


<210>  251
<211>  721
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Ser Pro Glu 
            660                 665                 670         


Ile Lys Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr 
        675                 680                 685             


Leu Lys Lys Leu Leu Gln Glu Asp Thr Pro Val Arg Lys Leu Gln Ala 
    690                 695                 700                 


Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser 
705                 710                 715                 720 


Gln 
    


<210>  252
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Arg Leu Phe Thr Gly Ile Val Phe Cys Ser Leu Val Met Gly Val 
1               5                   10                  15      


Thr Ser Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala Leu Gln Gly Val 
            20                  25                  30          


Gly Asp Met Gly Arg Ala Tyr Trp Asp Ile Met Ile Ser Asn His Gln 
        35                  40                  45              


Asn Ser Asn Arg Tyr Leu Tyr Ala Arg Gly Asn Tyr Asp Ala Ala Gln 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Lys Leu Ile Ser Arg Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Gly Leu Ile Asp Cys Tyr Leu Phe Gly Asn Ser Ser 
                85                  90                  95      


Thr Val Leu Glu Asp Ser Lys Ser Asn Glu Lys Ala Glu Glu Trp Gly 
            100                 105                 110         


Arg Ser Gly Lys Asp Pro Asp Arg Phe Arg Pro Asp Gly Leu Pro Lys 
        115                 120                 125             


Lys Tyr 
    130 


<210>  253
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  253

Met Thr Pro Trp Leu Gly Leu Ile Val Leu Leu Gly Ser Trp Ser Leu 
1               5                   10                  15      


Gly Asp Trp Gly Ala Glu Ala Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210>  254
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Val Asp Arg Glu Gln Leu Val Gln Lys Ala Arg Leu Ala Glu Gln 
1               5                   10                  15      


Ala Glu Arg Tyr Asp Asp Met Ala Ala Ala Met Lys Asn Val Thr Glu 
            20                  25                  30          


Leu Asn Glu Pro Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala 
        35                  40                  45              


Tyr Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Ile Ser 
    50                  55                  60                  


Ser Ile Glu Gln Lys Thr Ser Ala Asp Gly Asn Glu Lys Lys Ile Glu 
65                  70                  75                  80  


Met Val Arg Ala Tyr Arg Glu Lys Ile Glu Lys Glu Leu Glu Ala Val 
                85                  90                  95      


Cys Gln Asp Val Leu Ser Leu Leu Asp Asn Tyr Leu Ile Lys Asn Cys 
            100                 105                 110         


Ser Glu Thr Gln Tyr Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly 
        115                 120                 125             


Asp Tyr Tyr Arg Tyr Leu Ala Glu Val Ala Thr Gly Glu Lys Arg Ala 
    130                 135                 140                 


Thr Val Val Glu Ser Ser Glu Lys Ala Tyr Ser Glu Ala His Glu Ile 
145                 150                 155                 160 


Ser Lys Glu His Met Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala 
                165                 170                 175     


Leu Asn Tyr Ser Val Phe Tyr Tyr Glu Ile Gln Asn Ala Pro Glu Gln 
            180                 185                 190         


Ala Cys His Leu Ala Lys Thr Ala Phe Asp Asp Ala Ile Ala Glu Leu 
        195                 200                 205             


Asp Thr Leu Asn Glu Asp Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln 
    210                 215                 220                 


Leu Leu Arg Asp Asn Leu Thr Leu Trp Thr Ser Asp Gln Gln Asp Asp 
225                 230                 235                 240 


Asp Gly Gly Glu Gly Asn Asn 
                245         


<210>  255
<211>  909
<212>  PRT
<213>  Homo sapiens

<400>  255

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Val Ile Leu Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr 
        115                 120                 125             


Ser Asp Ser Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu 
    130                 135                 140                 


Ile Val Phe Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala 
145                 150                 155                 160 


Thr Asn Arg Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg 
                165                 170                 175     


Gly Ser Cys Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn 
            180                 185                 190         


Val Phe Pro Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu 
        195                 200                 205             


Thr Leu Lys Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn 
    210                 215                 220                 


Arg Glu Phe Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg 
225                 230                 235                 240 


Leu Ile Glu Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn 
                245                 250                 255     


Ile Arg Ile Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys 
            260                 265                 270         


Cys Ser Val Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp 
        275                 280                 285             


Trp Arg Lys Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln 
    290                 295                 300                 


Leu Val Ser Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro 
305                 310                 315                 320 


Ile Met Ser Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp 
                325                 330                 335     


His Ser Asp Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu 
            340                 345                 350         


Gly His Asn Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser 
        355                 360                 365             


Cys Gln Met Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr 
    370                 375                 380                 


Gly Tyr Pro Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu 
385                 390                 395                 400 


Glu Thr Ser Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro 
                405                 410                 415     


Glu Val Arg Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val 
            420                 425                 430         


Glu Glu Gly Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn 
        435                 440                 445             


Arg Cys Cys Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys 
    450                 455                 460                 


Ala His Gly Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr 
465                 470                 475                 480 


Ala Cys Arg Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr 
                485                 490                 495     


Gly Ala Ser Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His 
            500                 505                 510         


Ser Cys Gln Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr 
        515                 520                 525             


His Glu Gln Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala 
    530                 535                 540                 


Pro Gly Ile Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly 
545                 550                 555                 560 


Asn Cys Gly Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg 
                565                 570                 575     


Asp Ala Lys Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro 
            580                 585                 590         


Val Ile Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln 
        595                 600                 605             


Gln Gly Gly Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp 
    610                 615                 620                 


Asp Met Pro Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp 
625                 630                 635                 640 


Gly Lys Ile Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly 
                645                 650                 655     


Val His Glu Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn 
            660                 665                 670         


Arg Lys Asn Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp 
        675                 680                 685             


Lys Phe Gly Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala 
    690                 695                 700                 


Asp Asn Gln Gly Leu Thr Ile Gly Ile Leu Val Thr Ile Leu Cys Leu 
705                 710                 715                 720 


Leu Ala Ala Gly Phe Val Val Tyr Leu Lys Arg Lys Thr Leu Ile Arg 
                725                 730                 735     


Leu Leu Phe Thr Asn Lys Lys Thr Thr Ile Glu Lys Leu Arg Cys Val 
            740                 745                 750         


Arg Pro Ser Arg Pro Pro Arg Gly Phe Gln Pro Cys Gln Ala His Leu 
        755                 760                 765             


Gly His Leu Gly Lys Gly Leu Met Arg Lys Pro Pro Asp Ser Tyr Pro 
    770                 775                 780                 


Pro Lys Asp Asn Pro Arg Arg Leu Leu Gln Cys Gln Asn Val Asp Ile 
785                 790                 795                 800 


Ser Arg Pro Leu Asn Gly Leu Asn Val Pro Gln Pro Gln Ser Thr Gln 
                805                 810                 815     


Arg Val Leu Pro Pro Leu His Arg Ala Pro Arg Ala Pro Ser Val Pro 
            820                 825                 830         


Ala Arg Pro Leu Pro Ala Lys Pro Ala Leu Arg Gln Ala Gln Gly Thr 
        835                 840                 845             


Cys Lys Pro Asn Pro Pro Gln Lys Pro Leu Pro Ala Asp Pro Leu Ala 
    850                 855                 860                 


Arg Thr Thr Arg Leu Thr His Ala Leu Ala Arg Thr Pro Gly Gln Trp 
865                 870                 875                 880 


Glu Thr Gly Leu Arg Leu Ala Pro Leu Arg Pro Ala Pro Gln Tyr Pro 
                885                 890                 895     


His Gln Val Pro Arg Ser Thr His Thr Ala Tyr Ile Lys 
            900                 905                 


<210>  256
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Val Ile Leu Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr 
        115                 120                 125             


Ser Asp Ser Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu 
    130                 135                 140                 


Ile Val Phe Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala 
145                 150                 155                 160 


Thr Asn Arg Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg 
                165                 170                 175     


Gly Ser Cys Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn 
            180                 185                 190         


Val Phe Pro Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu 
        195                 200                 205             


Thr Leu Lys Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn 
    210                 215                 220                 


Arg Glu Phe Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg 
225                 230                 235                 240 


Leu Ile Glu Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn 
                245                 250                 255     


Ile Arg Ile Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys 
            260                 265                 270         


Cys Ser Val Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp 
        275                 280                 285             


Trp Arg Lys Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln 
    290                 295                 300                 


Leu Val Ser Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro 
305                 310                 315                 320 


Ile Met Ser Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp 
                325                 330                 335     


His Ser Asp Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu 
            340                 345                 350         


Gly His Asn Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser 
        355                 360                 365             


Cys Gln Met Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr 
    370                 375                 380                 


Gly Tyr Pro Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu 
385                 390                 395                 400 


Glu Thr Ser Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro 
                405                 410                 415     


Glu Val Arg Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val 
            420                 425                 430         


Glu Glu Gly Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn 
        435                 440                 445             


Arg Cys Cys Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys 
    450                 455                 460                 


Ala His Gly Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr 
465                 470                 475                 480 


Ala Cys Arg Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr 
                485                 490                 495     


Gly Ala Ser Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His 
            500                 505                 510         


Ser Cys Gln Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr 
        515                 520                 525             


His Glu Gln Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala 
    530                 535                 540                 


Pro Gly Ile Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly 
545                 550                 555                 560 


Asn Cys Gly Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg 
                565                 570                 575     


Asp Ala Lys Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro 
            580                 585                 590         


Val Ile Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln 
        595                 600                 605             


Gln Gly Gly Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp 
    610                 615                 620                 


Asp Met Pro Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp 
625                 630                 635                 640 


Gly Lys Ile Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly 
                645                 650                 655     


Val His Glu Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn 
            660                 665                 670         


Arg Lys Asn Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp 
        675                 680                 685             


Lys Phe Gly Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala 
    690                 695                 700                 


Glu Ala Arg Gln Glu Ala Ala Glu Ser Asn Arg Glu Arg Gly Gln Gly 
705                 710                 715                 720 


Gln Glu Pro Val Gly Ser Gln Glu His Ala Ser Thr Ala Ser Leu Thr 
                725                 730                 735     


Leu Ile 
        


<210>  257
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr Ser Asp Ser 
        115                 120                 125             


Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu Ile Val Phe 
    130                 135                 140                 


Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala Thr Asn Arg 
145                 150                 155                 160 


Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg Gly Ser Cys 
                165                 170                 175     


Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn Val Phe Pro 
            180                 185                 190         


Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu Thr Leu Lys 
        195                 200                 205             


Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn Arg Glu Phe 
    210                 215                 220                 


Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg Leu Ile Glu 
225                 230                 235                 240 


Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn Ile Arg Ile 
                245                 250                 255     


Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys Cys Ser Val 
            260                 265                 270         


Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp Trp Arg Lys 
        275                 280                 285             


Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln Leu Val Ser 
    290                 295                 300                 


Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro Ile Met Ser 
305                 310                 315                 320 


Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp His Ser Asp 
                325                 330                 335     


Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser Cys Gln Met 
        355                 360                 365             


Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr Gly Tyr Pro 
    370                 375                 380                 


Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu Glu Thr Ser 
385                 390                 395                 400 


Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro Glu Val Arg 
                405                 410                 415     


Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val Glu Glu Gly 
            420                 425                 430         


Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn Arg Cys Cys 
        435                 440                 445             


Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys Ala His Gly 
    450                 455                 460                 


Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr Ala Cys Arg 
465                 470                 475                 480 


Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr Gly Ala Ser 
                485                 490                 495     


Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His Ser Cys Gln 
            500                 505                 510         


Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr His Glu Gln 
        515                 520                 525             


Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala Pro Gly Ile 
    530                 535                 540                 


Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly Asn Cys Gly 
545                 550                 555                 560 


Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg Asp Ala Lys 
                565                 570                 575     


Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro Val Ile Gly 
            580                 585                 590         


Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln Gln Gly Gly 
        595                 600                 605             


Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp Asp Met Pro 
    610                 615                 620                 


Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp Gly Lys Ile 
625                 630                 635                 640 


Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly Val His Glu 
                645                 650                 655     


Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn Arg Lys Asn 
            660                 665                 670         


Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp Lys Phe Gly 
        675                 680                 685             


Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala Glu Ala Arg 
    690                 695                 700                 


Gln Glu Ala Ala Glu Ser Asn Arg Glu Arg Gly Gln Gly Gln Glu Pro 
705                 710                 715                 720 


Val Gly Ser Gln Glu His Ala Ser Thr Ala Ser Leu Thr Leu Ile 
                725                 730                 735 


<210>  258
<211>  737
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Ala Ala Arg Pro Leu Pro Val Ser Pro Ala Arg Ala Leu Leu Leu 
1               5                   10                  15      


Ala Leu Ala Gly Ala Leu Leu Ala Pro Cys Glu Ala Arg Gly Val Ser 
            20                  25                  30          


Leu Trp Asn Gln Gly Arg Ala Asp Glu Val Val Ser Ala Ser Val Gly 
        35                  40                  45              


Ser Gly Asp Leu Trp Ile Pro Val Lys Ser Phe Asp Ser Lys Asn His 
    50                  55                  60                  


Pro Glu Val Leu Asn Ile Arg Leu Gln Arg Glu Ser Lys Glu Leu Ile 
65                  70                  75                  80  


Ile Asn Leu Glu Arg Asn Glu Gly Leu Ile Ala Ser Ser Phe Thr Glu 
                85                  90                  95      


Thr His Tyr Leu Gln Asp Gly Thr Asp Val Ser Leu Ala Arg Asn Tyr 
            100                 105                 110         


Thr Gly His Cys Tyr Tyr His Gly His Val Arg Gly Tyr Ser Asp Ser 
        115                 120                 125             


Ala Val Ser Leu Ser Thr Cys Ser Gly Leu Arg Gly Leu Ile Val Phe 
    130                 135                 140                 


Glu Asn Glu Ser Tyr Val Leu Glu Pro Met Lys Ser Ala Thr Asn Arg 
145                 150                 155                 160 


Tyr Lys Leu Phe Pro Ala Lys Lys Leu Lys Ser Val Arg Gly Ser Cys 
                165                 170                 175     


Gly Ser His His Asn Thr Pro Asn Leu Ala Ala Lys Asn Val Phe Pro 
            180                 185                 190         


Pro Pro Ser Gln Thr Trp Ala Arg Arg His Lys Arg Glu Thr Leu Lys 
        195                 200                 205             


Ala Thr Lys Tyr Val Glu Leu Val Ile Val Ala Asp Asn Arg Glu Phe 
    210                 215                 220                 


Gln Arg Gln Gly Lys Asp Leu Glu Lys Val Lys Gln Arg Leu Ile Glu 
225                 230                 235                 240 


Ile Ala Asn His Val Asp Lys Phe Tyr Arg Pro Leu Asn Ile Arg Ile 
                245                 250                 255     


Val Leu Val Gly Val Glu Val Trp Asn Asp Met Asp Lys Cys Ser Val 
            260                 265                 270         


Ser Gln Asp Pro Phe Thr Ser Leu His Glu Phe Leu Asp Trp Arg Lys 
        275                 280                 285             


Met Lys Leu Leu Pro Arg Lys Ser His Asp Asn Ala Gln Leu Val Ser 
    290                 295                 300                 


Gly Val Tyr Phe Gln Gly Thr Thr Ile Gly Met Ala Pro Ile Met Ser 
305                 310                 315                 320 


Met Cys Thr Ala Asp Gln Ser Gly Gly Ile Val Met Asp His Ser Asp 
                325                 330                 335     


Asn Pro Leu Gly Ala Ala Val Thr Leu Ala His Glu Leu Gly His Asn 
            340                 345                 350         


Phe Gly Met Asn His Asp Thr Leu Asp Arg Gly Cys Ser Cys Gln Met 
        355                 360                 365             


Ala Val Glu Lys Gly Gly Cys Ile Met Asn Ala Ser Thr Gly Tyr Pro 
    370                 375                 380                 


Phe Pro Met Val Phe Ser Ser Cys Ser Arg Lys Asp Leu Glu Thr Ser 
385                 390                 395                 400 


Leu Glu Lys Gly Met Gly Val Cys Leu Phe Asn Leu Pro Glu Val Arg 
                405                 410                 415     


Glu Ser Phe Gly Gly Gln Lys Cys Gly Asn Arg Phe Val Glu Glu Gly 
            420                 425                 430         


Glu Glu Cys Asp Cys Gly Glu Pro Glu Glu Cys Met Asn Arg Cys Cys 
        435                 440                 445             


Asn Ala Thr Thr Cys Thr Leu Lys Pro Asp Ala Val Cys Ala His Gly 
    450                 455                 460                 


Leu Cys Cys Glu Asp Cys Gln Leu Lys Pro Ala Gly Thr Ala Cys Arg 
465                 470                 475                 480 


Asp Ser Ser Asn Ser Cys Asp Leu Pro Glu Phe Cys Thr Gly Ala Ser 
                485                 490                 495     


Pro His Cys Pro Ala Asn Val Tyr Leu His Asp Gly His Ser Cys Gln 
            500                 505                 510         


Asp Val Asp Gly Tyr Cys Tyr Asn Gly Ile Cys Gln Thr His Glu Gln 
        515                 520                 525             


Gln Cys Val Thr Leu Trp Gly Pro Gly Ala Lys Pro Ala Pro Gly Ile 
    530                 535                 540                 


Cys Phe Glu Arg Val Asn Ser Ala Gly Asp Pro Tyr Gly Asn Cys Gly 
545                 550                 555                 560 


Lys Val Ser Lys Ser Ser Phe Ala Lys Cys Glu Met Arg Asp Ala Lys 
                565                 570                 575     


Cys Gly Lys Ile Gln Cys Gln Gly Gly Ala Ser Arg Pro Val Ile Gly 
            580                 585                 590         


Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Pro Leu Gln Gln Gly Gly 
        595                 600                 605             


Arg Ile Leu Cys Arg Gly Thr His Val Tyr Leu Gly Asp Asp Met Pro 
    610                 615                 620                 


Asp Pro Gly Leu Val Leu Ala Gly Thr Lys Cys Ala Asp Gly Lys Ile 
625                 630                 635                 640 


Cys Leu Asn Arg Gln Cys Gln Asn Ile Ser Val Phe Gly Val His Glu 
                645                 650                 655     


Cys Ala Met Gln Cys His Gly Arg Gly Val Cys Asn Asn Arg Lys Asn 
            660                 665                 670         


Cys His Cys Glu Ala His Trp Ala Pro Pro Phe Cys Asp Lys Phe Gly 
        675                 680                 685             


Phe Gly Gly Ser Thr Asp Ser Gly Pro Ile Arg Gln Ala Gly Lys Glu 
    690                 695                 700                 


Ala Arg Gln Glu Ala Ala Glu Ser Asn Arg Glu Arg Gly Gln Gly Gln 
705                 710                 715                 720 


Glu Pro Val Gly Ser Gln Glu His Ala Ser Thr Ala Ser Leu Thr Leu 
                725                 730                 735     


Ile 
    


<210>  259
<211>  955
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Pro Gly Gly Ala Gly Ala Ala Arg Leu Cys Leu Leu Ala Phe Ala 
1               5                   10                  15      


Leu Gln Pro Leu Arg Pro Arg Ala Ala Arg Glu Pro Gly Trp Thr Arg 
            20                  25                  30          


Gly Ser Glu Glu Gly Ser Pro Lys Leu Gln His Glu Leu Ile Ile Pro 
        35                  40                  45              


Gln Trp Lys Thr Ser Glu Ser Pro Val Arg Glu Lys His Pro Leu Lys 
    50                  55                  60                  


Ala Glu Leu Arg Val Met Ala Glu Gly Arg Glu Leu Ile Leu Asp Leu 
65                  70                  75                  80  


Glu Lys Asn Glu Gln Leu Phe Ala Pro Ser Tyr Thr Glu Thr His Tyr 
                85                  90                  95      


Thr Ser Ser Gly Asn Pro Gln Thr Thr Thr Arg Lys Leu Glu Asp His 
            100                 105                 110         


Cys Phe Tyr His Gly Thr Val Arg Glu Thr Glu Leu Ser Ser Val Thr 
        115                 120                 125             


Leu Ser Thr Cys Arg Gly Ile Arg Gly Leu Ile Thr Val Ser Ser Asn 
    130                 135                 140                 


Leu Ser Tyr Val Ile Glu Pro Leu Pro Asp Ser Lys Gly Gln His Leu 
145                 150                 155                 160 


Ile Tyr Arg Ser Glu His Leu Lys Pro Pro Pro Gly Asn Cys Gly Phe 
                165                 170                 175     


Glu His Ser Lys Pro Thr Thr Arg Asp Trp Ala Leu Gln Phe Thr Gln 
            180                 185                 190         


Gln Thr Lys Lys Arg Pro Arg Arg Met Lys Arg Glu Asp Leu Asn Ser 
        195                 200                 205             


Met Lys Tyr Val Glu Leu Tyr Leu Val Ala Asp Tyr Leu Glu Phe Gln 
    210                 215                 220                 


Lys Asn Arg Arg Asp Gln Asp Ala Thr Lys His Lys Leu Ile Glu Ile 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Lys Phe Tyr Arg Ser Leu Asn Ile Arg Ile Ala 
                245                 250                 255     


Leu Val Gly Leu Glu Val Trp Thr His Gly Asn Met Cys Glu Val Ser 
            260                 265                 270         


Glu Asn Pro Tyr Ser Thr Leu Trp Ser Phe Leu Ser Trp Arg Arg Lys 
        275                 280                 285             


Leu Leu Ala Gln Lys Tyr His Asp Asn Ala Gln Leu Ile Thr Gly Met 
    290                 295                 300                 


Ser Phe His Gly Thr Thr Ile Gly Leu Ala Pro Leu Met Ala Met Cys 
305                 310                 315                 320 


Ser Val Tyr Gln Ser Gly Gly Val Asn Met Asp His Ser Glu Asn Ala 
                325                 330                 335     


Ile Gly Val Ala Ala Thr Met Ala His Glu Met Gly His Asn Phe Gly 
            340                 345                 350         


Met Thr His Asp Ser Ala Asp Cys Cys Ser Ala Ser Ala Ala Asp Gly 
        355                 360                 365             


Gly Cys Ile Met Ala Ala Ala Thr Gly His Pro Phe Pro Lys Val Phe 
    370                 375                 380                 


Asn Gly Cys Asn Arg Arg Glu Leu Asp Arg Tyr Leu Gln Ser Gly Gly 
385                 390                 395                 400 


Gly Met Cys Leu Ser Asn Met Pro Asp Thr Arg Met Leu Tyr Gly Gly 
                405                 410                 415     


Arg Arg Cys Gly Asn Gly Tyr Leu Glu Asp Gly Glu Glu Cys Asp Cys 
            420                 425                 430         


Gly Glu Glu Glu Glu Cys Asn Asn Pro Cys Cys Asn Ala Ser Asn Cys 
        435                 440                 445             


Thr Leu Arg Pro Gly Ala Glu Cys Ala His Gly Ser Cys Cys His Gln 
    450                 455                 460                 


Cys Lys Leu Leu Ala Pro Gly Thr Leu Cys Arg Glu Gln Ala Arg Gln 
465                 470                 475                 480 


Cys Asp Leu Pro Glu Phe Cys Thr Gly Lys Ser Pro His Cys Pro Thr 
                485                 490                 495     


Asn Phe Tyr Gln Met Asp Gly Thr Pro Cys Glu Gly Gly Gln Ala Tyr 
            500                 505                 510         


Cys Tyr Asn Gly Met Cys Leu Thr Tyr Gln Glu Gln Cys Gln Gln Leu 
        515                 520                 525             


Trp Gly Pro Gly Ala Arg Pro Ala Pro Asp Leu Cys Phe Glu Lys Val 
    530                 535                 540                 


Asn Val Ala Gly Asp Thr Phe Gly Asn Cys Gly Lys Asp Met Asn Gly 
545                 550                 555                 560 


Glu His Arg Lys Cys Asn Met Arg Asp Ala Lys Cys Gly Lys Ile Gln 
                565                 570                 575     


Cys Gln Ser Ser Glu Ala Arg Pro Leu Glu Ser Asn Ala Val Pro Ile 
            580                 585                 590         


Asp Thr Thr Ile Ile Met Asn Gly Arg Gln Ile Gln Cys Arg Gly Thr 
        595                 600                 605             


His Val Tyr Arg Gly Pro Glu Glu Glu Gly Asp Met Leu Asp Pro Gly 
    610                 615                 620                 


Leu Val Met Thr Gly Thr Lys Cys Gly Tyr Asn His Ile Cys Phe Glu 
625                 630                 635                 640 


Gly Gln Cys Arg Asn Thr Ser Phe Phe Glu Thr Glu Gly Cys Gly Lys 
                645                 650                 655     


Lys Cys Asn Gly His Gly Val Cys Asn Asn Asn Gln Asn Cys His Cys 
            660                 665                 670         


Leu Pro Gly Trp Ala Pro Pro Phe Cys Asn Thr Pro Gly His Gly Gly 
        675                 680                 685             


Ser Ile Asp Ser Gly Pro Met Pro Pro Glu Ser Val Gly Pro Val Val 
    690                 695                 700                 


Ala Gly Val Leu Val Ala Ile Leu Val Leu Ala Val Leu Met Leu Met 
705                 710                 715                 720 


Tyr Tyr Cys Cys Arg Gln Asn Asn Lys Leu Gly Gln Leu Lys Pro Ser 
                725                 730                 735     


Ala Leu Pro Ser Lys Leu Arg Gln Gln Phe Ser Cys Pro Phe Arg Val 
            740                 745                 750         


Ser Gln Asn Ser Gly Thr Gly His Ala Asn Pro Thr Phe Lys Leu Gln 
        755                 760                 765             


Thr Pro Gln Gly Lys Arg Lys Val Ile Asn Thr Pro Glu Ile Leu Arg 
    770                 775                 780                 


Lys Pro Ser Gln Pro Pro Pro Arg Pro Pro Pro Asp Tyr Leu Arg Gly 
785                 790                 795                 800 


Gly Ser Pro Pro Ala Pro Leu Pro Ala His Leu Ser Arg Ala Ala Arg 
                805                 810                 815     


Asn Ser Pro Gly Pro Gly Ser Gln Ile Glu Arg Thr Glu Ser Ser Arg 
            820                 825                 830         


Arg Pro Pro Pro Ser Arg Pro Ile Pro Pro Ala Pro Asn Cys Ile Val 
        835                 840                 845             


Ser Gln Asp Phe Ser Arg Pro Arg Pro Pro Gln Lys Ala Leu Pro Ala 
    850                 855                 860                 


Asn Pro Val Pro Gly Arg Arg Ser Leu Pro Arg Pro Gly Gly Ala Ser 
865                 870                 875                 880 


Pro Leu Arg Pro Pro Gly Ala Gly Pro Gln Gln Ser Arg Pro Leu Ala 
                885                 890                 895     


Ala Leu Ala Pro Lys Val Ser Pro Arg Glu Ala Leu Lys Val Lys Ala 
            900                 905                 910         


Gly Thr Arg Gly Leu Gln Gly Gly Arg Cys Arg Val Glu Lys Thr Lys 
        915                 920                 925             


Gln Phe Met Leu Leu Val Val Trp Thr Glu Leu Pro Glu Gln Lys Pro 
    930                 935                 940                 


Arg Ala Lys His Ser Cys Phe Leu Val Pro Ala 
945                 950                 955 


<210>  260
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Pro Gly Gly Ala Gly Ala Ala Arg Leu Cys Leu Leu Ala Phe Ala 
1               5                   10                  15      


Leu Gln Pro Leu Arg Pro Arg Ala Ala Arg Glu Pro Gly Trp Thr Arg 
            20                  25                  30          


Gly Ser Glu Glu Gly Ser Pro Lys Leu Gln His Glu Leu Ile Ile Pro 
        35                  40                  45              


Gln Trp Lys Thr Ser Glu Ser Pro Val Arg Glu Lys His Pro Leu Lys 
    50                  55                  60                  


Ala Glu Leu Arg Val Met Ala Glu Gly Arg Glu Leu Ile Leu Asp Leu 
65                  70                  75                  80  


Glu Lys Asn Glu Gln Leu Phe Ala Pro Ser Tyr Thr Glu Thr His Tyr 
                85                  90                  95      


Thr Ser Ser Gly Asn Pro Gln Thr Thr Thr Arg Lys Leu Glu Asp His 
            100                 105                 110         


Cys Phe Tyr His Gly Thr Val Arg Glu Thr Glu Leu Ser Ser Val Thr 
        115                 120                 125             


Leu Ser Thr Cys Arg Gly Ile Arg Gly Leu Ile Thr Val Ser Ser Asn 
    130                 135                 140                 


Leu Ser Tyr Val Ile Glu Pro Leu Pro Asp Ser Lys Gly Gln His Leu 
145                 150                 155                 160 


Ile Tyr Arg Ser Glu His Leu Lys Pro Pro Pro Gly Asn Cys Gly Phe 
                165                 170                 175     


Glu His Ser Lys Pro Thr Thr Arg Asp Trp Ala Leu Gln Phe Thr Gln 
            180                 185                 190         


Gln Thr Lys Lys Arg Pro Arg Arg Met Lys Arg Glu Asp Leu Asn Ser 
        195                 200                 205             


Met Lys Tyr Val Glu Leu Tyr Leu Val Ala Asp Tyr Leu Glu Phe Gln 
    210                 215                 220                 


Lys Asn Arg Arg Asp Gln Asp Ala Thr Lys His Lys Leu Ile Glu Ile 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Lys Phe Tyr Arg Ser Leu Asn Ile Arg Ile Ala 
                245                 250                 255     


Leu Val Gly Leu Glu Val Trp Thr His Gly Asn Met Cys Glu Val Ser 
            260                 265                 270         


Glu Asn Pro Tyr Ser Thr Leu Trp Ser Phe Leu Ser Trp Arg Arg Lys 
        275                 280                 285             


Leu Leu Ala Gln Lys Tyr His Asp Asn Ala Gln Leu Ile Thr Gly Met 
    290                 295                 300                 


Ser Phe His Gly Thr Thr Ile Gly Leu Ala Pro Leu Met Ala Met Cys 
305                 310                 315                 320 


Ser Val Tyr Gln Ser Gly Gly Val Asn Met Asp His Ser Glu Asn Ala 
                325                 330                 335     


Ile Gly Val Ala Ala Thr Met Ala His Glu Met Gly His Asn Phe Gly 
            340                 345                 350         


Met Thr His Asp Ser Ala Asp Cys Cys Ser Ala Ser Ala Ala Asp Gly 
        355                 360                 365             


Gly Cys Ile Met Ala Ala Ala Thr Gly His Pro Phe Pro Lys Val Phe 
    370                 375                 380                 


Asn Gly Cys Asn Arg Arg Glu Leu Asp Arg Tyr Leu Gln Ser Gly Gly 
385                 390                 395                 400 


Gly Met Cys Leu Ser Asn Met Pro Asp Thr Arg Met Leu Tyr Gly Gly 
                405                 410                 415     


Arg Arg Cys Gly Asn Gly Tyr Leu Glu Asp Gly Glu Glu Cys Asp Cys 
            420                 425                 430         


Gly Glu Glu Glu Glu Cys Asn Asn Pro Cys Cys Asn Ala Ser Asn Cys 
        435                 440                 445             


Thr Leu Arg Pro Gly Ala Glu Cys Ala His Gly Ser Cys Cys His Gln 
    450                 455                 460                 


Cys Lys Leu Leu Ala Pro Gly Thr Leu Cys Arg Glu Gln Ala Arg Gln 
465                 470                 475                 480 


Cys Asp Leu Pro Glu Phe Cys Thr Gly Lys Ser Pro His Cys Pro Thr 
                485                 490                 495     


Asn Phe Tyr Gln Met Asp Gly Thr Pro Cys Glu Gly Gly Gln Ala Tyr 
            500                 505                 510         


Cys Tyr Asn Gly Met Cys Leu Thr Tyr Gln Glu Gln Cys Gln Gln Leu 
        515                 520                 525             


Trp Gly Pro Gly Ala Arg Pro Ala Pro Asp Leu Cys Phe Glu Lys Val 
    530                 535                 540                 


Asn Val Ala Gly Asp Thr Phe Gly Asn Cys Gly Lys Asp Met Asn Gly 
545                 550                 555                 560 


Glu His Arg Lys Cys Asn Met Arg Asp Ala Lys Cys Gly Lys Ile Gln 
                565                 570                 575     


Cys Gln Ser Ser Glu Ala Arg Pro Leu Glu Ser Asn Ala Val Pro Ile 
            580                 585                 590         


Asp Thr Thr Ile Ile Met Asn Gly Arg Gln Ile Gln Cys Arg Gly Thr 
        595                 600                 605             


His Val Tyr Arg Gly Pro Glu Glu Glu Gly Asp Met Leu Asp Pro Gly 
    610                 615                 620                 


Leu Val Met Thr Gly Thr Lys Cys Gly Tyr Asn His Ile Cys Phe Glu 
625                 630                 635                 640 


Gly Gln Cys Arg Asn Thr Ser Phe Phe Glu Thr Glu Gly Cys Gly Lys 
                645                 650                 655     


Lys Cys Asn Gly His Gly Val Cys Asn Asn Asn Gln Asn Cys His Cys 
            660                 665                 670         


Leu Pro Gly Trp Ala Pro Pro Phe Cys Asn Thr Pro Gly His Gly Gly 
        675                 680                 685             


Ser Ile Asp Ser Gly Pro Met Pro Pro Glu Ser Val Gly Pro Val Val 
    690                 695                 700                 


Ala Gly Val Leu Val Ala Ile Leu Val Leu Ala Val Leu Met Leu Met 
705                 710                 715                 720 


Tyr Tyr Cys Cys Arg Gln Asn Asn Lys Leu Gly Gln Leu Lys Pro Ser 
                725                 730                 735     


Ala Leu Pro Ser Lys Leu Arg Gln Gln Phe Ser Cys Pro Phe Arg Val 
            740                 745                 750         


Ser Gln Asn Ser Gly Thr Gly His Ala Asn Pro Thr Phe Lys Leu Gln 
        755                 760                 765             


Thr Pro Gln Gly Lys Arg Lys Val Ile Asn Thr Pro Glu Ile Leu Arg 
    770                 775                 780                 


Lys Pro Ser Gln Pro Pro Pro Arg Pro Pro Pro Asp Tyr Leu Arg Gly 
785                 790                 795                 800 


Gly Ser Pro Pro Ala Pro Leu Pro Ala His Leu Ser Arg Ala Ala Arg 
                805                 810                 815     


Asn Ser Pro Gly Pro Gly Ser Gln Ile Glu Arg Thr Glu Ser Ser Arg 
            820                 825                 830         


Arg Pro Pro Pro Ser Arg Pro Ile Pro Pro Ala Pro Asn Cys Ile Val 
        835                 840                 845             


Ser Gln Asp Phe Ser Arg Pro Arg Pro Pro Gln Lys Ala Leu Pro Ala 
    850                 855                 860                 


Asn Pro Val Pro Gly Arg Arg Ser Leu Pro Arg Pro Gly Gly Ala Ser 
865                 870                 875                 880 


Pro Leu Arg Pro Pro Gly Ala Gly Pro Gln Gln Ser Arg Pro Leu Ala 
                885                 890                 895     


Ala Leu Ala Pro Lys Phe Pro Glu Tyr Arg Ser Gln Arg Ala Gly Gly 
            900                 905                 910         


Met Ile Ser Ser Lys Ile 
        915             


<210>  261
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  261

Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210>  262
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Thr Asp Thr Lys 
    50                  55                  60  


<210>  263
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  263

Met Thr Leu Glu Glu Val Arg Gly Gln Asp Thr Val Pro Glu Ser Thr 
1               5                   10                  15      


Ala Arg Met Gln Gly Ala Gly Lys Ala Leu His Glu Leu Leu Leu Ser 
            20                  25                  30          


Ala Gln Arg Gln Gly Cys Leu Thr Ala Gly Val Tyr Glu Ser Ala Lys 
        35                  40                  45              


Val Leu Asn Val Asp Pro Asp Asn Val Thr Phe Cys Val Leu Ala Ala 
    50                  55                  60                  


Gly Glu Glu Asp Glu Gly Asp Ile Ala Leu Gln Ile His Phe Thr Leu 
65                  70                  75                  80  


Ile Gln Ala Phe Cys Cys Glu Asn Asp Ile Asp Ile Val Arg Val Gly 
                85                  90                  95      


Asp Val Gln Arg Leu Ala Ala Ile Val Gly Ala Gly Glu Glu Ala Gly 
            100                 105                 110         


Ala Pro Gly Asp Leu His Cys Ile Leu Ile Ser Asn Pro Asn Glu Asp 
        115                 120                 125             


Ala Trp Lys Asp Pro Ala Leu Glu Lys Leu Ser Leu Phe Cys Glu Glu 
    130                 135                 140                 


Ser Arg Ser Val Asn Asp Trp Val Pro Ser Ile Thr Leu Pro Glu 
145                 150                 155                 


<210>  264
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  264

Met Lys Leu Ala Ala Met Ile Lys Lys Met Cys Pro Ser Asp Ser Glu 
1               5                   10                  15      


Leu Ser Ile Pro Ala Lys Asn Cys Tyr Arg Met Val Ile Leu Gly Ser 
            20                  25                  30          


Ser Lys Val Gly Lys Thr Ala Ile Val Ser Arg Phe Leu Thr Gly Arg 
        35                  40                  45              


Phe Glu Asp Ala Tyr Thr Pro Thr Ile Glu Asp Phe His Arg Lys Phe 
    50                  55                  60                  


Tyr Ser Ile Arg Gly Glu Val Tyr Gln Leu Asp Ile Leu Asp Thr Ser 
65                  70                  75                  80  


Gly Asn His Pro Phe Pro Ala Met Arg Arg Leu Ser Ile Leu Thr Gly 
                85                  90                  95      


Asp Val Phe Ile Leu Val Phe Ser Leu Asp Asn Arg Asp Ser Phe Glu 
            100                 105                 110         


Glu Val Gln Arg Leu Arg Gln Gln Ile Leu Asp Thr Lys Ser Cys Leu 
        115                 120                 125             


Lys Asn Lys Thr Lys Glu Asn Val Asp Val Pro Leu Val Ile Cys Gly 
    130                 135                 140                 


Asn Lys Gly Asp Arg Asp Phe Tyr Arg Glu Val Asp Gln Arg Glu Ile 
145                 150                 155                 160 


Glu Gln Leu Val Gly Asp Asp Pro Gln Arg Cys Ala Tyr Phe Glu Ile 
                165                 170                 175     


Ser Ala Lys Lys Asn Ser Ser Leu Asp Gln Met Phe Arg Ala Leu Phe 
            180                 185                 190         


Ala Met Ala Lys Leu Pro Ser Glu Met Ser Pro Asp Leu His Arg Lys 
        195                 200                 205             


Val Ser Val Gln Tyr Cys Asp Val Leu His Lys Lys Ala Leu Arg Asn 
    210                 215                 220                 


Lys Lys Leu Leu Arg Ala Gly Ser Gly Gly Gly Gly Gly Asp Pro Gly 
225                 230                 235                 240 


Asp Ala Phe Gly Ile Val Ala Pro Phe Ala Arg Arg Pro Ser Val His 
                245                 250                 255     


Ser Asp Leu Met Tyr Ile Arg Glu Lys Ala Ser Ala Gly Ser Gln Ala 
            260                 265                 270         


Lys Asp Lys Glu Arg Cys Val Ile Ser 
        275                 280     


<210>  265
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  265

Met Lys Leu Ala Ala Met Ile Lys Lys Met Cys Pro Ser Asp Ser Glu 
1               5                   10                  15      


Leu Ser Ile Pro Ala Lys Asn Cys Tyr Arg Met Val Ile Leu Gly Ser 
            20                  25                  30          


Ser Lys Val Gly Lys Thr Ala Ile Val Ser Arg Phe Leu Thr Gly Arg 
        35                  40                  45              


Phe Glu Asp Ala Tyr Thr Pro Thr Ile Glu Asp Phe His Arg Lys Phe 
    50                  55                  60                  


Tyr Ser Ile Arg Gly Glu Val Tyr Gln Leu Asp Ile Leu Asp Thr Ser 
65                  70                  75                  80  


Gly Asn His Pro Phe Pro Ala Met Arg Arg Leu Ser Ile Leu Thr Asp 
                85                  90                  95      


Pro Arg His Gln Val Leu Pro Gln Glu Gln Asn Gln Gly Glu Arg Gly 
            100                 105                 110         


Arg Ala Pro Gly His Leu Arg Gln Gln Gly 
        115                 120         


<210>  266
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  266

Met Cys Arg Thr Leu Ala Ala Phe Pro Thr Thr Cys Leu Glu Arg Ala 
1               5                   10                  15      


Lys Glu Phe Lys Thr Arg Leu Gly Ile Phe Leu His Lys Ser Glu Leu 
            20                  25                  30          


Gly Cys Asp Thr Gly Ser Thr Gly Lys Phe Glu Trp Gly Ser Lys His 
        35                  40                  45              


Ser Lys Glu Asn Arg Asn Phe Ser Glu Asp Val Leu Gly Trp Arg Glu 
    50                  55                  60                  


Ser Phe Asp Leu Leu Leu Ser Ser Lys Asn Gly Val Ala Ala Phe His 
65                  70                  75                  80  


Ala Phe Leu Lys Thr Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Leu 
                85                  90                  95      


Ala Cys Glu Glu Phe Lys Lys Ile Arg Ser Ala Thr Lys Leu Ala Ser 
            100                 105                 110         


Arg Ala His Gln Ile Phe Glu Glu Phe Ile Cys Ser Glu Ala Pro Lys 
        115                 120                 125             


Glu Val Asn Ile Asp His Glu Thr His Glu Leu Thr Arg Met Asn Leu 
    130                 135                 140                 


Gln Thr Ala Thr Ala Thr Cys Phe Asp Ala Ala Gln Gly Lys Thr Arg 
145                 150                 155                 160 


Thr Leu Met Glu Lys Asp Ser Tyr Pro Arg Phe Leu Lys Ser Pro Ala 
                165                 170                 175     


Tyr Arg Asp Leu Ala Ala Gln Ala Ser Ala Ala Ser Ala Thr Leu Ser 
            180                 185                 190         


Ser Cys Ser Leu Asp Glu Pro Ser His Thr 
        195                 200         


