                         SEQUENCE LISTING

<110>  Samumed, LLC
 
<120>  METHODS OF TREATING CARTILAGE DISORDERS THROUGH INHIBITION OF CLK
        AND DYRK

<130>  29124-0140WO1

<150>  62/793,855
<151>  2019-01-17

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  484
<212>  PRT
<213>  Artificial

<220>
<223>  Human CLK1 protein isoform 1

<400>  1

Met Arg His Ser Lys Arg Thr Tyr Cys Pro Asp Trp Asp Asp Lys Asp 
1               5                   10                  15      


Trp Asp Tyr Gly Lys Trp Arg Ser Ser Ser Ser His Lys Arg Arg Lys 
            20                  25                  30          


Arg Ser His Ser Ser Ala Gln Glu Asn Lys Arg Cys Lys Tyr Asn His 
        35                  40                  45              


Ser Lys Met Cys Asp Ser His Tyr Leu Glu Ser Arg Ser Ile Asn Glu 
    50                  55                  60                  


Lys Asp Tyr His Ser Arg Arg Tyr Ile Asp Glu Tyr Arg Asn Asp Tyr 
65                  70                  75                  80  


Thr Gln Gly Cys Glu Pro Gly His Arg Gln Arg Asp His Glu Ser Arg 
                85                  90                  95      


Tyr Gln Asn His Ser Ser Lys Ser Ser Gly Arg Ser Gly Arg Ser Ser 
            100                 105                 110         


Tyr Lys Ser Lys His Arg Ile His His Ser Thr Ser His Arg Arg Ser 
        115                 120                 125             


His Gly Lys Ser His Arg Arg Lys Arg Thr Arg Ser Val Glu Asp Asp 
    130                 135                 140                 


Glu Glu Gly His Leu Ile Cys Gln Ser Gly Asp Val Leu Ser Ala Arg 
145                 150                 155                 160 


Tyr Glu Ile Val Asp Thr Leu Gly Glu Gly Ala Phe Gly Lys Val Val 
                165                 170                 175     


Glu Cys Ile Asp His Lys Ala Gly Gly Arg His Val Ala Val Lys Ile 
            180                 185                 190         


Val Lys Asn Val Asp Arg Tyr Cys Glu Ala Ala Arg Ser Glu Ile Gln 
        195                 200                 205             


Val Leu Glu His Leu Asn Thr Thr Asp Pro Asn Ser Thr Phe Arg Cys 
    210                 215                 220                 


Val Gln Met Leu Glu Trp Phe Glu His His Gly His Ile Cys Ile Val 
225                 230                 235                 240 


Phe Glu Leu Leu Gly Leu Ser Thr Tyr Asp Phe Ile Lys Glu Asn Gly 
                245                 250                 255     


Phe Leu Pro Phe Arg Leu Asp His Ile Arg Lys Met Ala Tyr Gln Ile 
            260                 265                 270         


Cys Lys Ser Val Asn Phe Leu His Ser Asn Lys Leu Thr His Thr Asp 
        275                 280                 285             


Leu Lys Pro Glu Asn Ile Leu Phe Val Gln Ser Asp Tyr Thr Glu Ala 
    290                 295                 300                 


Tyr Asn Pro Lys Ile Lys Arg Asp Glu Arg Thr Leu Ile Asn Pro Asp 
305                 310                 315                 320 


Ile Lys Val Val Asp Phe Gly Ser Ala Thr Tyr Asp Asp Glu His His 
                325                 330                 335     


Ser Thr Leu Val Ser Thr Arg His Tyr Arg Ala Pro Glu Val Ile Leu 
            340                 345                 350         


Ala Leu Gly Trp Ser Gln Pro Cys Asp Val Trp Ser Ile Gly Cys Ile 
        355                 360                 365             


Leu Ile Glu Tyr Tyr Leu Gly Phe Thr Val Phe Pro Thr His Asp Ser 
    370                 375                 380                 


Lys Glu His Leu Ala Met Met Glu Arg Ile Leu Gly Pro Leu Pro Lys 
385                 390                 395                 400 


His Met Ile Gln Lys Thr Arg Lys Arg Lys Tyr Phe His His Asp Arg 
                405                 410                 415     


Leu Asp Trp Asp Glu His Ser Ser Ala Gly Arg Tyr Val Ser Arg Arg 
            420                 425                 430         


Cys Lys Pro Leu Lys Glu Phe Met Leu Ser Gln Asp Val Glu His Glu 
        435                 440                 445             


Arg Leu Phe Asp Leu Ile Gln Lys Met Leu Glu Tyr Asp Pro Ala Lys 
    450                 455                 460                 


Arg Ile Thr Leu Arg Glu Ala Leu Lys His Pro Phe Phe Asp Leu Leu 
465                 470                 475                 480 


Lys Lys Ser Ile 
                


<210>  2
<211>  1455
<212>  DNA
<213>  Artificial

<220>
<223>  Human CLK1 cDNA isoform 1

<400>  2
atgagacact caaagagaac ttactgtcct gattgggatg acaaggattg ggattatgga       60

aaatggagga gcagcagcag tcataaaaga aggaagagat cacatagcag tgcccaggag      120

aacaagcgct gcaaatacaa tcactctaaa atgtgtgata gccattattt ggaaagcagg      180

tctataaatg agaaagatta tcatagtcga cgctacattg atgagtacag aaatgactac      240

actcaaggat gtgaacctgg acatcgccaa agagaccatg aaagccggta tcagaaccat      300

agtagcaagt cttctggtag aagtggaaga agtagttata aaagcaaaca caggattcac      360

cacagtactt cacatcgtcg ttcacatggg aagagtcacc gaaggaaaag aaccaggagt      420

gtagaggatg atgaggaggg tcacctgatc tgtcagagtg gagacgtact aagtgcaaga      480

tatgaaattg ttgatacttt aggtgaagga gcttttggaa aagttgtgga gtgcatcgat      540

cataaagcgg gaggtagaca tgtagcagta aaaatagtta aaaatgtgga tagatactgt      600

gaagctgctc gctcagaaat acaagttctg gaacatctga atacaacaga ccccaacagt      660

actttccgct gtgtccagat gttggaatgg tttgagcatc atggtcacat ttgcattgtt      720

tttgaactat tgggacttag tacttacgac ttcattaaag aaaatggttt tctaccattt      780

cgactggatc atatcagaaa gatggcatat cagatatgca agtctgtgaa ttttttgcac      840

agtaataagt tgactcacac agacttaaag cctgaaaaca tcttatttgt gcagtctgac      900

tacacagagg cgtataatcc caaaataaaa cgtgatgaac gcaccttaat aaatccagat      960

attaaagttg tagactttgg tagtgcaaca tatgatgacg aacatcacag tacattggta     1020

tctacaagac attatagagc acctgaagtt attttagccc tagggtggtc ccaaccatgt     1080

gatgtctgga gcataggatg cattcttatt gaatactatc ttgggtttac cgtatttcca     1140

acacacgata gtaaggagca tttagcaatg atggaaagga ttcttggacc tctaccaaaa     1200

catatgatac agaaaaccag gaaacgtaaa tattttcacc acgatcgatt agactgggat     1260

gaacacagtt ctgccggcag atatgtttca agacgctgta aacctctgaa ggaatttatg     1320

ctttctcaag atgttgaaca tgagcgtctc tttgacctca ttcagaaaat gttggagtat     1380

gatccagcca aaagaattac tctcagagaa gccttaaagc atcctttctt tgaccttctg     1440

aagaaaagta tatag                                                      1455


<210>  3
<211>  526
<212>  PRT
<213>  Artificial

<220>
<223>  Human CLK1 protein isoform 2

<400>  3

Met Ala Ala Gly Arg Arg Pro Ala Ser Ala Leu Trp Pro Glu Arg Arg 
1               5                   10                  15      


Gly Ser Pro Leu Arg Gly Asp Leu Leu Gly Phe Gln Asn Val Arg Glu 
            20                  25                  30          


Pro Ser Ser Cys Gly Glu Thr Leu Ser Gly Met Arg His Ser Lys Arg 
        35                  40                  45              


Thr Tyr Cys Pro Asp Trp Asp Asp Lys Asp Trp Asp Tyr Gly Lys Trp 
    50                  55                  60                  


Arg Ser Ser Ser Ser His Lys Arg Arg Lys Arg Ser His Ser Ser Ala 
65                  70                  75                  80  


Gln Glu Asn Lys Arg Cys Lys Tyr Asn His Ser Lys Met Cys Asp Ser 
                85                  90                  95      


His Tyr Leu Glu Ser Arg Ser Ile Asn Glu Lys Asp Tyr His Ser Arg 
            100                 105                 110         


Arg Tyr Ile Asp Glu Tyr Arg Asn Asp Tyr Thr Gln Gly Cys Glu Pro 
        115                 120                 125             


Gly His Arg Gln Arg Asp His Glu Ser Arg Tyr Gln Asn His Ser Ser 
    130                 135                 140                 


Lys Ser Ser Gly Arg Ser Gly Arg Ser Ser Tyr Lys Ser Lys His Arg 
145                 150                 155                 160 


Ile His His Ser Thr Ser His Arg Arg Ser His Gly Lys Ser His Arg 
                165                 170                 175     


Arg Lys Arg Thr Arg Ser Val Glu Asp Asp Glu Glu Gly His Leu Ile 
            180                 185                 190         


Cys Gln Ser Gly Asp Val Leu Ser Ala Arg Tyr Glu Ile Val Asp Thr 
        195                 200                 205             


Leu Gly Glu Gly Ala Phe Gly Lys Val Val Glu Cys Ile Asp His Lys 
    210                 215                 220                 


Ala Gly Gly Arg His Val Ala Val Lys Ile Val Lys Asn Val Asp Arg 
225                 230                 235                 240 


Tyr Cys Glu Ala Ala Arg Ser Glu Ile Gln Val Leu Glu His Leu Asn 
                245                 250                 255     


Thr Thr Asp Pro Asn Ser Thr Phe Arg Cys Val Gln Met Leu Glu Trp 
            260                 265                 270         


Phe Glu His His Gly His Ile Cys Ile Val Phe Glu Leu Leu Gly Leu 
        275                 280                 285             


Ser Thr Tyr Asp Phe Ile Lys Glu Asn Gly Phe Leu Pro Phe Arg Leu 
    290                 295                 300                 


Asp His Ile Arg Lys Met Ala Tyr Gln Ile Cys Lys Ser Val Asn Phe 
305                 310                 315                 320 


Leu His Ser Asn Lys Leu Thr His Thr Asp Leu Lys Pro Glu Asn Ile 
                325                 330                 335     


Leu Phe Val Gln Ser Asp Tyr Thr Glu Ala Tyr Asn Pro Lys Ile Lys 
            340                 345                 350         


Arg Asp Glu Arg Thr Leu Ile Asn Pro Asp Ile Lys Val Val Asp Phe 
        355                 360                 365             


Gly Ser Ala Thr Tyr Asp Asp Glu His His Ser Thr Leu Val Ser Thr 
    370                 375                 380                 


Arg His Tyr Arg Ala Pro Glu Val Ile Leu Ala Leu Gly Trp Ser Gln 
385                 390                 395                 400 


Pro Cys Asp Val Trp Ser Ile Gly Cys Ile Leu Ile Glu Tyr Tyr Leu 
                405                 410                 415     


Gly Phe Thr Val Phe Pro Thr His Asp Ser Lys Glu His Leu Ala Met 
            420                 425                 430         


Met Glu Arg Ile Leu Gly Pro Leu Pro Lys His Met Ile Gln Lys Thr 
        435                 440                 445             


Arg Lys Arg Lys Tyr Phe His His Asp Arg Leu Asp Trp Asp Glu His 
    450                 455                 460                 


Ser Ser Ala Gly Arg Tyr Val Ser Arg Arg Cys Lys Pro Leu Lys Glu 
465                 470                 475                 480 


Phe Met Leu Ser Gln Asp Val Glu His Glu Arg Leu Phe Asp Leu Ile 
                485                 490                 495     


Gln Lys Met Leu Glu Tyr Asp Pro Ala Lys Arg Ile Thr Leu Arg Glu 
            500                 505                 510         


Ala Leu Lys His Pro Phe Phe Asp Leu Leu Lys Lys Ser Ile 
        515                 520                 525     


<210>  4
<211>  1581
<212>  DNA
<213>  Artificial

<220>
<223>  Human CLK1 cDNA isoform 2

<400>  4
atggcggctg ggcggaggcc ggcttcggcc ctgtggccgg aaaggcgagg ctccccgttg       60

aggggggatt tgctggggtt ccagaatgtg cgtgagccaa gcagctgtgg ggaaacgttg      120

tctggaatga gacactcaaa gagaacttac tgtcctgatt gggatgacaa ggattgggat      180

tatggaaaat ggaggagcag cagcagtcat aaaagaagga agagatcaca tagcagtgcc      240

caggagaaca agcgctgcaa atacaatcac tctaaaatgt gtgatagcca ttatttggaa      300

agcaggtcta taaatgagaa agattatcat agtcgacgct acattgatga gtacagaaat      360

gactacactc aaggatgtga acctggacat cgccaaagag accatgaaag ccggtatcag      420

aaccatagta gcaagtcttc tggtagaagt ggaagaagta gttataaaag caaacacagg      480

attcaccaca gtacttcaca tcgtcgttca catgggaaga gtcaccgaag gaaaagaacc      540

aggagtgtag aggatgatga ggagggtcac ctgatctgtc agagtggaga cgtactaagt      600

gcaagatatg aaattgttga tactttaggt gaaggagctt ttggaaaagt tgtggagtgc      660

atcgatcata aagcgggagg tagacatgta gcagtaaaaa tagttaaaaa tgtggataga      720

tactgtgaag ctgctcgctc agaaatacaa gttctggaac atctgaatac aacagacccc      780

aacagtactt tccgctgtgt ccagatgttg gaatggtttg agcatcatgg tcacatttgc      840

attgtttttg aactattggg acttagtact tacgacttca ttaaagaaaa tggttttcta      900

ccatttcgac tggatcatat cagaaagatg gcatatcaga tatgcaagtc tgtgaatttt      960

ttgcacagta ataagttgac tcacacagac ttaaagcctg aaaacatctt atttgtgcag     1020

tctgactaca cagaggcgta taatcccaaa ataaaacgtg atgaacgcac cttaataaat     1080

ccagatatta aagttgtaga ctttggtagt gcaacatatg atgacgaaca tcacagtaca     1140

ttggtatcta caagacatta tagagcacct gaagttattt tagccctagg gtggtcccaa     1200

ccatgtgatg tctggagcat aggatgcatt cttattgaat actatcttgg gtttaccgta     1260

tttccaacac acgatagtaa ggagcattta gcaatgatgg aaaggattct tggacctcta     1320

ccaaaacata tgatacagaa aaccaggaaa cgtaaatatt ttcaccacga tcgattagac     1380

tgggatgaac acagttctgc cggcagatat gtttcaagac gctgtaaacc tctgaaggaa     1440

tttatgcttt ctcaagatgt tgaacatgag cgtctctttg acctcattca gaaaatgttg     1500

gagtatgatc cagccaaaag aattactctc agagaagcct taaagcatcc tttctttgac     1560

cttctgaaga aaagtatata g                                               1581


<210>  5
<211>  499
<212>  PRT
<213>  Artificial

<220>
<223>  Human CLK2 protein isoform 1

<400>  5

Met Pro His Pro Arg Arg Tyr His Ser Ser Glu Arg Gly Ser Arg Gly 
1               5                   10                  15      


Ser Tyr Arg Glu His Tyr Arg Ser Arg Lys His Lys Arg Arg Arg Ser 
            20                  25                  30          


Arg Ser Trp Ser Ser Ser Ser Asp Arg Thr Arg Arg Arg Arg Arg Glu 
        35                  40                  45              


Asp Ser Tyr His Val Arg Ser Arg Ser Ser Tyr Asp Asp Arg Ser Ser 
    50                  55                  60                  


Asp Arg Arg Val Tyr Asp Arg Arg Tyr Cys Gly Ser Tyr Arg Arg Asn 
65                  70                  75                  80  


Asp Tyr Ser Arg Asp Arg Gly Asp Ala Tyr Tyr Asp Thr Asp Tyr Arg 
                85                  90                  95      


His Ser Tyr Glu Tyr Gln Arg Glu Asn Ser Ser Tyr Arg Ser Gln Arg 
            100                 105                 110         


Ser Ser Arg Arg Lys His Arg Arg Arg Arg Arg Arg Ser Arg Thr Phe 
        115                 120                 125             


Ser Arg Ser Ser Ser Gln His Ser Ser Arg Arg Ala Lys Ser Val Glu 
    130                 135                 140                 


Asp Asp Ala Glu Gly His Leu Ile Tyr His Val Gly Asp Trp Leu Gln 
145                 150                 155                 160 


Glu Arg Tyr Glu Ile Val Ser Thr Leu Gly Glu Gly Thr Phe Gly Arg 
                165                 170                 175     


Val Val Gln Cys Val Asp His Arg Arg Gly Gly Ala Arg Val Ala Leu 
            180                 185                 190         


Lys Ile Ile Lys Asn Val Glu Lys Tyr Lys Glu Ala Ala Arg Leu Glu 
        195                 200                 205             


Ile Asn Val Leu Glu Lys Ile Asn Glu Lys Asp Pro Asp Asn Lys Asn 
    210                 215                 220                 


Leu Cys Val Gln Met Phe Asp Trp Phe Asp Tyr His Gly His Met Cys 
225                 230                 235                 240 


Ile Ser Phe Glu Leu Leu Gly Leu Ser Thr Phe Asp Phe Leu Lys Asp 
                245                 250                 255     


Asn Asn Tyr Leu Pro Tyr Pro Ile His Gln Val Arg His Met Ala Phe 
            260                 265                 270         


Gln Leu Cys Gln Ala Val Lys Phe Leu His Asp Asn Lys Leu Thr His 
        275                 280                 285             


Thr Asp Leu Lys Pro Glu Asn Ile Leu Phe Val Asn Ser Asp Tyr Glu 
    290                 295                 300                 


Leu Thr Tyr Asn Leu Glu Lys Lys Arg Asp Glu Arg Ser Val Lys Ser 
305                 310                 315                 320 


Thr Ala Val Arg Val Val Asp Phe Gly Ser Ala Thr Phe Asp His Glu 
                325                 330                 335     


His His Ser Thr Ile Val Ser Thr Arg His Tyr Arg Ala Pro Glu Val 
            340                 345                 350         


Ile Leu Glu Leu Gly Trp Ser Gln Pro Cys Asp Val Trp Ser Ile Gly 
        355                 360                 365             


Cys Ile Ile Phe Glu Tyr Tyr Val Gly Phe Thr Leu Phe Gln Thr His 
    370                 375                 380                 


Asp Asn Arg Glu His Leu Ala Met Met Glu Arg Ile Leu Gly Pro Ile 
385                 390                 395                 400 


Pro Ser Arg Met Ile Arg Lys Thr Arg Lys Gln Lys Tyr Phe Tyr Arg 
                405                 410                 415     


Gly Arg Leu Asp Trp Asp Glu Asn Thr Ser Ala Gly Arg Tyr Val Arg 
            420                 425                 430         


Glu Asn Cys Lys Pro Leu Arg Arg Tyr Leu Thr Ser Glu Ala Glu Glu 
        435                 440                 445             


His His Gln Leu Phe Asp Leu Ile Glu Ser Met Leu Glu Tyr Glu Pro 
    450                 455                 460                 


Ala Lys Arg Leu Thr Leu Gly Glu Ala Leu Gln His Pro Phe Phe Ala 
465                 470                 475                 480 


Arg Leu Arg Ala Glu Pro Pro Asn Lys Leu Trp Asp Ser Ser Arg Asp 
                485                 490                 495     


Ile Ser Arg 
            


<210>  6
<211>  1500
<212>  DNA
<213>  Artificial

<220>
<223>  Human CLK2 cDNA isoform 1

<400>  6
atgccgcatc ctcgaaggta ccactcctca gagcgaggca gccgggggag ttaccgtgaa       60

cactatcgga gccgaaagca taagcgacga agaagtcgct cctggtcaag tagtagtgac      120

cggacacgac ggcgtcggcg agaggacagc taccatgtcc gttctcgaag cagttatgat      180

gatcgttcgt ccgaccggag ggtgtatgac cggcgatact gtggcagcta cagacgcaac      240

gattatagcc gggatcgggg agatgcctac tatgacacag actatcggca ttcctatgaa      300

tatcagcggg agaacagcag ttaccgcagc cagcgcagca gccggaggaa gcacagacgg      360

cggaggaggc gcagccggac atttagccgc tcatcttcgc agcacagcag ccggagagcc      420

aagagtgtag aggacgacgc tgagggccac ctcatctacc acgtcgggga ctggctacaa      480

gagcgatatg aaatcgttag caccttagga gaggggacct tcggccgagt tgtacaatgt      540

gttgaccatc gcaggggtgg ggctcgagtt gccctgaaga tcattaagaa tgtggagaag      600

tacaaggaag cagctcgact tgagatcaac gtgctagaga aaatcaatga gaaagaccct      660

gacaacaaga acctctgtgt ccagatgttt gactggtttg actaccatgg ccacatgtgt      720

atctcctttg agcttctggg ccttagcacc ttcgatttcc tcaaagacaa caactacctg      780

ccctacccca tccaccaagt gcgccacatg gccttccagc tgtgccaggc tgtcaagttc      840

ctccatgata acaagctgac acatacagac ctcaagcctg aaaatattct gtttgtgaat      900

tcagactatg agctcaccta caacctagag aagaagcgag atgagcgcag tgtgaagagc      960

acagctgtgc gggtggtaga ctttggcagt gccacctttg accatgagca ccatagcacc     1020

attgtctcca ctcgccatta ccgagcacca gaagtcatcc ttgagttggg ctggtcacag     1080

ccttgtgatg tgtggagtat aggctgcatc atctttgaat actatgtggg attcaccctc     1140

ttccagaccc atgacaacag agagcatcta gccatgatgg aaaggatctt gggtcctatc     1200

ccttcccgga tgatccgaaa gacaagaaag cagaaatatt tttaccgggg tcgcctggat     1260

tgggatgaga acacatcagc tgggcgctat gttcgtgaga actgcaaacc gctgcggcgg     1320

tatctgacct cagaggcaga ggaacaccac cagctcttcg atctgattga aagcatgcta     1380

gagtatgaac cagctaagcg gctgaccttg ggtgaagccc ttcagcatcc tttcttcgcc     1440

cgccttcggg ctgagccgcc caacaagttg tgggactcca gtcgggatat cagtcggtga     1500


<210>  7
<211>  498
<212>  PRT
<213>  Artificial

<220>
<223>  Human CLK2 protein isoform 2

<400>  7

Met Pro His Pro Arg Arg Tyr His Ser Ser Glu Arg Gly Ser Arg Gly 
1               5                   10                  15      


Ser Tyr Arg Glu His Tyr Arg Ser Arg Lys His Lys Arg Arg Arg Ser 
            20                  25                  30          


Arg Ser Trp Ser Ser Ser Ser Asp Arg Thr Arg Arg Arg Arg Arg Glu 
        35                  40                  45              


Asp Ser Tyr His Val Arg Ser Arg Ser Ser Tyr Asp Asp Arg Ser Ser 
    50                  55                  60                  


Asp Arg Arg Val Tyr Asp Arg Arg Tyr Cys Gly Ser Tyr Arg Arg Asn 
65                  70                  75                  80  


Asp Tyr Ser Arg Asp Arg Gly Asp Ala Tyr Tyr Asp Thr Asp Tyr Arg 
                85                  90                  95      


His Ser Tyr Glu Tyr Gln Arg Glu Asn Ser Ser Tyr Arg Ser Gln Arg 
            100                 105                 110         


Ser Ser Arg Arg Lys His Arg Arg Arg Arg Arg Arg Ser Arg Thr Phe 
        115                 120                 125             


Ser Arg Ser Ser Ser His Ser Ser Arg Arg Ala Lys Ser Val Glu Asp 
    130                 135                 140                 


Asp Ala Glu Gly His Leu Ile Tyr His Val Gly Asp Trp Leu Gln Glu 
145                 150                 155                 160 


Arg Tyr Glu Ile Val Ser Thr Leu Gly Glu Gly Thr Phe Gly Arg Val 
                165                 170                 175     


Val Gln Cys Val Asp His Arg Arg Gly Gly Ala Arg Val Ala Leu Lys 
            180                 185                 190         


Ile Ile Lys Asn Val Glu Lys Tyr Lys Glu Ala Ala Arg Leu Glu Ile 
        195                 200                 205             


Asn Val Leu Glu Lys Ile Asn Glu Lys Asp Pro Asp Asn Lys Asn Leu 
    210                 215                 220                 


Cys Val Gln Met Phe Asp Trp Phe Asp Tyr His Gly His Met Cys Ile 
225                 230                 235                 240 


Ser Phe Glu Leu Leu Gly Leu Ser Thr Phe Asp Phe Leu Lys Asp Asn 
                245                 250                 255     


Asn Tyr Leu Pro Tyr Pro Ile His Gln Val Arg His Met Ala Phe Gln 
            260                 265                 270         


Leu Cys Gln Ala Val Lys Phe Leu His Asp Asn Lys Leu Thr His Thr 
        275                 280                 285             


Asp Leu Lys Pro Glu Asn Ile Leu Phe Val Asn Ser Asp Tyr Glu Leu 
    290                 295                 300                 


Thr Tyr Asn Leu Glu Lys Lys Arg Asp Glu Arg Ser Val Lys Ser Thr 
305                 310                 315                 320 


Ala Val Arg Val Val Asp Phe Gly Ser Ala Thr Phe Asp His Glu His 
                325                 330                 335     


His Ser Thr Ile Val Ser Thr Arg His Tyr Arg Ala Pro Glu Val Ile 
            340                 345                 350         


Leu Glu Leu Gly Trp Ser Gln Pro Cys Asp Val Trp Ser Ile Gly Cys 
        355                 360                 365             


Ile Ile Phe Glu Tyr Tyr Val Gly Phe Thr Leu Phe Gln Thr His Asp 
    370                 375                 380                 


Asn Arg Glu His Leu Ala Met Met Glu Arg Ile Leu Gly Pro Ile Pro 
385                 390                 395                 400 


Ser Arg Met Ile Arg Lys Thr Arg Lys Gln Lys Tyr Phe Tyr Arg Gly 
                405                 410                 415     


Arg Leu Asp Trp Asp Glu Asn Thr Ser Ala Gly Arg Tyr Val Arg Glu 
            420                 425                 430         


Asn Cys Lys Pro Leu Arg Arg Tyr Leu Thr Ser Glu Ala Glu Glu His 
        435                 440                 445             


His Gln Leu Phe Asp Leu Ile Glu Ser Met Leu Glu Tyr Glu Pro Ala 
    450                 455                 460                 


Lys Arg Leu Thr Leu Gly Glu Ala Leu Gln His Pro Phe Phe Ala Arg 
465                 470                 475                 480 


Leu Arg Ala Glu Pro Pro Asn Lys Leu Trp Asp Ser Ser Arg Asp Ile 
                485                 490                 495     


Ser Arg 
        


<210>  8
<211>  1497
<212>  DNA
<213>  Artificial

<220>
<223>  Human CLK2 cDNA isoform 2

<400>  8
atgccgcatc ctcgaaggta ccactcctca gagcgaggca gccgggggag ttaccgtgaa       60

cactatcgga gccgaaagca taagcgacga agaagtcgct cctggtcaag tagtagtgac      120

cggacacgac ggcgtcggcg agaggacagc taccatgtcc gttctcgaag cagttatgat      180

gatcgttcgt ccgaccggag ggtgtatgac cggcgatact gtggcagcta cagacgcaac      240

gattatagcc gggatcgggg agatgcctac tatgacacag actatcggca ttcctatgaa      300

tatcagcggg agaacagcag ttaccgcagc cagcgcagca gccggaggaa gcacagacgg      360

cggaggaggc gcagccggac atttagccgc tcatcttcgc acagcagccg gagagccaag      420

agtgtagagg acgacgctga gggccacctc atctaccacg tcggggactg gctacaagag      480

cgatatgaaa tcgttagcac cttaggagag gggaccttcg gccgagttgt acaatgtgtt      540

gaccatcgca ggggtggggc tcgagttgcc ctgaagatca ttaagaatgt ggagaagtac      600

aaggaagcag ctcgacttga gatcaacgtg ctagagaaaa tcaatgagaa agaccctgac      660

aacaagaacc tctgtgtcca gatgtttgac tggtttgact accatggcca catgtgtatc      720

tcctttgagc ttctgggcct tagcaccttc gatttcctca aagacaacaa ctacctgccc      780

taccccatcc accaagtgcg ccacatggcc ttccagctgt gccaggctgt caagttcctc      840

catgataaca agctgacaca tacagacctc aagcctgaaa atattctgtt tgtgaattca      900

gactatgagc tcacctacaa cctagagaag aagcgagatg agcgcagtgt gaagagcaca      960

gctgtgcggg tggtagactt tggcagtgcc acctttgacc atgagcacca tagcaccatt     1020

gtctccactc gccattaccg agcaccagaa gtcatccttg agttgggctg gtcacagcct     1080

tgtgatgtgt ggagtatagg ctgcatcatc tttgaatact atgtgggatt caccctcttc     1140

cagacccatg acaacagaga gcatctagcc atgatggaaa ggatcttggg tcctatccct     1200

tcccggatga tccgaaagac aagaaagcag aaatattttt accggggtcg cctggattgg     1260

gatgagaaca catcagctgg gcgctatgtt cgtgagaact gcaaaccgct gcggcggtat     1320

ctgacctcag aggcagagga acaccaccag ctcttcgatc tgattgaaag catgctagag     1380

tatgaaccag ctaagcggct gaccttgggt gaagcccttc agcatccttt cttcgcccgc     1440

cttcgggctg agccgcccaa caagttgtgg gactccagtc gggatatcag tcggtga        1497


<210>  9
<211>  271
<212>  PRT
<213>  Artificial

<220>
<223>  Human CLK2 protein isoform 3

<400>  9

Met Phe Asp Trp Phe Asp Tyr His Gly His Met Cys Ile Ser Phe Glu 
1               5                   10                  15      


Leu Leu Gly Leu Ser Thr Phe Asp Phe Leu Lys Asp Asn Asn Tyr Leu 
            20                  25                  30          


Pro Tyr Pro Ile His Gln Val Arg His Met Ala Phe Gln Leu Cys Gln 
        35                  40                  45              


Ala Val Lys Phe Leu His Asp Asn Lys Leu Thr His Thr Asp Leu Lys 
    50                  55                  60                  


Pro Glu Asn Ile Leu Phe Val Asn Ser Asp Tyr Glu Leu Thr Tyr Asn 
65                  70                  75                  80  


Leu Glu Lys Lys Arg Asp Glu Arg Ser Val Lys Ser Thr Ala Val Arg 
                85                  90                  95      


Val Val Asp Phe Gly Ser Ala Thr Phe Asp His Glu His His Ser Thr 
            100                 105                 110         


Ile Val Ser Thr Arg His Tyr Arg Ala Pro Glu Val Ile Leu Glu Leu 
        115                 120                 125             


Gly Trp Ser Gln Pro Cys Asp Val Trp Ser Ile Gly Cys Ile Ile Phe 
    130                 135                 140                 


Glu Tyr Tyr Val Gly Phe Thr Leu Phe Gln Thr His Asp Asn Arg Glu 
145                 150                 155                 160 


His Leu Ala Met Met Glu Arg Ile Leu Gly Pro Ile Pro Ser Arg Met 
                165                 170                 175     


Ile Arg Lys Thr Arg Lys Gln Lys Tyr Phe Tyr Arg Gly Arg Leu Asp 
            180                 185                 190         


Trp Asp Glu Asn Thr Ser Ala Gly Arg Tyr Val Arg Glu Asn Cys Lys 
        195                 200                 205             


Pro Leu Arg Arg Tyr Leu Thr Ser Glu Ala Glu Glu His His Gln Leu 
    210                 215                 220                 


Phe Asp Leu Ile Glu Ser Met Leu Glu Tyr Glu Pro Ala Lys Arg Leu 
225                 230                 235                 240 


Thr Leu Gly Glu Ala Leu Gln His Pro Phe Phe Ala Arg Leu Arg Ala 
                245                 250                 255     


Glu Pro Pro Asn Lys Leu Trp Asp Ser Ser Arg Asp Ile Ser Arg 
            260                 265                 270     


<210>  10
<211>  816
<212>  DNA
<213>  Artificial

<220>
<223>  Human CLK2 cDNA isoform 3

<400>  10
atgtttgact ggtttgacta ccatggccac atgtgtatct cctttgagct tctgggcctt       60

agcaccttcg atttcctcaa agacaacaac tacctgccct accccatcca ccaagtgcgc      120

cacatggcct tccagctgtg ccaggctgtc aagttcctcc atgataacaa gctgacacat      180

acagacctca agcctgaaaa tattctgttt gtgaattcag actatgagct cacctacaac      240

ctagagaaga agcgagatga gcgcagtgtg aagagcacag ctgtgcgggt ggtagacttt      300

ggcagtgcca cctttgacca tgagcaccat agcaccattg tctccactcg ccattaccga      360

gcaccagaag tcatccttga gttgggctgg tcacagcctt gtgatgtgtg gagtataggc      420

tgcatcatct ttgaatacta tgtgggattc accctcttcc agacccatga caacagagag      480

catctagcca tgatggaaag gatcttgggt cctatccctt cccggatgat ccgaaagaca      540

agaaagcaga aatattttta ccggggtcgc ctggattggg atgagaacac atcagctggg      600

cgctatgttc gtgagaactg caaaccgctg cggcggtatc tgacctcaga ggcagaggaa      660

caccaccagc tcttcgatct gattgaaagc atgctagagt atgaaccagc taagcggctg      720

accttgggtg aagcccttca gcatcctttc ttcgcccgcc ttcgggctga gccgcccaac      780

aagttgtggg actccagtcg ggatatcagt cggtga                                816


<210>  11
<211>  497
<212>  PRT
<213>  Artificial

<220>
<223>  Human CLK2 protein isoform 4

<400>  11

Met Pro His Pro Arg Arg Tyr His Ser Ser Glu Arg Gly Ser Arg Gly 
1               5                   10                  15      


Ser Tyr Arg Glu His Tyr Arg Ser Arg Lys His Lys Arg Arg Arg Ser 
            20                  25                  30          


Arg Ser Trp Ser Ser Ser Ser Asp Arg Thr Arg Arg Arg Arg Arg Glu 
        35                  40                  45              


Asp Ser Tyr His Val Arg Ser Arg Ser Tyr Asp Asp Arg Ser Ser Asp 
    50                  55                  60                  


Arg Arg Val Tyr Asp Arg Arg Tyr Cys Gly Ser Tyr Arg Arg Asn Asp 
65                  70                  75                  80  


Tyr Ser Arg Asp Arg Gly Asp Ala Tyr Tyr Asp Thr Asp Tyr Arg His 
                85                  90                  95      


Ser Tyr Glu Tyr Gln Arg Glu Asn Ser Ser Tyr Arg Ser Gln Arg Ser 
            100                 105                 110         


Ser Arg Arg Lys His Arg Arg Arg Arg Arg Arg Ser Arg Thr Phe Ser 
        115                 120                 125             


Arg Ser Ser Ser His Ser Ser Arg Arg Ala Lys Ser Val Glu Asp Asp 
    130                 135                 140                 


Ala Glu Gly His Leu Ile Tyr His Val Gly Asp Trp Leu Gln Glu Arg 
145                 150                 155                 160 


Tyr Glu Ile Val Ser Thr Leu Gly Glu Gly Thr Phe Gly Arg Val Val 
                165                 170                 175     


Gln Cys Val Asp His Arg Arg Gly Gly Ala Arg Val Ala Leu Lys Ile 
            180                 185                 190         


Ile Lys Asn Val Glu Lys Tyr Lys Glu Ala Ala Arg Leu Glu Ile Asn 
        195                 200                 205             


Val Leu Glu Lys Ile Asn Glu Lys Asp Pro Asp Asn Lys Asn Leu Cys 
    210                 215                 220                 


Val Gln Met Phe Asp Trp Phe Asp Tyr His Gly His Met Cys Ile Ser 
225                 230                 235                 240 


Phe Glu Leu Leu Gly Leu Ser Thr Phe Asp Phe Leu Lys Asp Asn Asn 
                245                 250                 255     


Tyr Leu Pro Tyr Pro Ile His Gln Val Arg His Met Ala Phe Gln Leu 
            260                 265                 270         


Cys Gln Ala Val Lys Phe Leu His Asp Asn Lys Leu Thr His Thr Asp 
        275                 280                 285             


Leu Lys Pro Glu Asn Ile Leu Phe Val Asn Ser Asp Tyr Glu Leu Thr 
    290                 295                 300                 


Tyr Asn Leu Glu Lys Lys Arg Asp Glu Arg Ser Val Lys Ser Thr Ala 
305                 310                 315                 320 


Val Arg Val Val Asp Phe Gly Ser Ala Thr Phe Asp His Glu His His 
                325                 330                 335     


Ser Thr Ile Val Ser Thr Arg His Tyr Arg Ala Pro Glu Val Ile Leu 
            340                 345                 350         


Glu Leu Gly Trp Ser Gln Pro Cys Asp Val Trp Ser Ile Gly Cys Ile 
        355                 360                 365             


Ile Phe Glu Tyr Tyr Val Gly Phe Thr Leu Phe Gln Thr His Asp Asn 
    370                 375                 380                 


Arg Glu His Leu Ala Met Met Glu Arg Ile Leu Gly Pro Ile Pro Ser 
385                 390                 395                 400 


Arg Met Ile Arg Lys Thr Arg Lys Gln Lys Tyr Phe Tyr Arg Gly Arg 
                405                 410                 415     


Leu Asp Trp Asp Glu Asn Thr Ser Ala Gly Arg Tyr Val Arg Glu Asn 
            420                 425                 430         


Cys Lys Pro Leu Arg Arg Tyr Leu Thr Ser Glu Ala Glu Glu His His 
        435                 440                 445             


Gln Leu Phe Asp Leu Ile Glu Ser Met Leu Glu Tyr Glu Pro Ala Lys 
    450                 455                 460                 


Arg Leu Thr Leu Gly Glu Ala Leu Gln His Pro Phe Phe Ala Arg Leu 
465                 470                 475                 480 


Arg Ala Glu Pro Pro Asn Lys Leu Trp Asp Ser Ser Arg Asp Ile Ser 
                485                 490                 495     


Arg 
    


<210>  12
<211>  1494
<212>  DNA
<213>  Artificial

<220>
<223>  Human CLK2 cDNA isoform 4

<400>  12
atgccgcatc ctcgaaggta ccactcctca gagcgaggca gccgggggag ttaccgtgaa       60

cactatcgga gccgaaagca taagcgacga agaagtcgct cctggtcaag tagtagtgac      120

cggacacgac ggcgtcggcg agaggacagc taccatgtcc gttctcgaag ttatgatgat      180

cgttcgtccg accggagggt gtatgaccgg cgatactgtg gcagctacag acgcaacgat      240

tatagccggg atcggggaga tgcctactat gacacagact atcggcattc ctatgaatat      300

cagcgggaga acagcagtta ccgcagccag cgcagcagcc ggaggaagca cagacggcgg      360

aggaggcgca gccggacatt tagccgctca tcttcgcaca gcagccggag agccaagagt      420

gtagaggacg acgctgaggg ccacctcatc taccacgtcg gggactggct acaagagcga      480

tatgaaatcg ttagcacctt aggagagggg accttcggcc gagttgtaca atgtgttgac      540

catcgcaggg gtggggctcg agttgccctg aagatcatta agaatgtgga gaagtacaag      600

gaagcagctc gacttgagat caacgtgcta gagaaaatca atgagaaaga ccctgacaac      660

aagaacctct gtgtccagat gtttgactgg tttgactacc atggccacat gtgtatctcc      720

tttgagcttc tgggccttag caccttcgat ttcctcaaag acaacaacta cctgccctac      780

cccatccacc aagtgcgcca catggccttc cagctgtgcc aggctgtcaa gttcctccat      840

gataacaagc tgacacatac agacctcaag cctgaaaata ttctgtttgt gaattcagac      900

tatgagctca cctacaacct agagaagaag cgagatgagc gcagtgtgaa gagcacagct      960

gtgcgggtgg tagactttgg cagtgccacc tttgaccatg agcaccatag caccattgtc     1020

tccactcgcc attaccgagc accagaagtc atccttgagt tgggctggtc acagccttgt     1080

gatgtgtgga gtataggctg catcatcttt gaatactatg tgggattcac cctcttccag     1140

acccatgaca acagagagca tctagccatg atggaaagga tcttgggtcc tatcccttcc     1200

cggatgatcc gaaagacaag aaagcagaaa tatttttacc ggggtcgcct ggattgggat     1260

gagaacacat cagctgggcg ctatgttcgt gagaactgca aaccgctgcg gcggtatctg     1320

acctcagagg cagaggaaca ccaccagctc ttcgatctga ttgaaagcat gctagagtat     1380

gaaccagcta agcggctgac cttgggtgaa gcccttcagc atcctttctt cgcccgcctt     1440

cgggctgagc cgcccaacaa gttgtgggac tccagtcggg atatcagtcg gtga           1494


<210>  13
<211>  638
<212>  PRT
<213>  Artificial

<220>
<223>  Human CLK3 protein isoform 1

<400>  13

Met Pro Val Leu Ser Ala Arg Arg Arg Glu Leu Ala Asp His Ala Gly 
1               5                   10                  15      


Ser Gly Arg Arg Ser Gly Pro Ser Pro Thr Ala Arg Ser Gly Pro His 
            20                  25                  30          


Leu Ser Ala Leu Arg Ala Gln Pro Ala Arg Ala Ala His Leu Ser Gly 
        35                  40                  45              


Arg Gly Thr Tyr Val Arg Arg Asp Thr Ala Gly Gly Gly Pro Gly Gln 
    50                  55                  60                  


Ala Arg Pro Leu Gly Pro Pro Gly Thr Ser Leu Leu Gly Arg Gly Ala 
65                  70                  75                  80  


Arg Arg Ser Gly Glu Gly Trp Cys Pro Gly Ala Phe Glu Ser Gly Ala 
                85                  90                  95      


Arg Ala Ala Arg Pro Pro Ser Arg Val Glu Pro Arg Leu Ala Thr Ala 
            100                 105                 110         


Ala Ser Arg Glu Gly Ala Gly Leu Pro Arg Ala Glu Val Ala Ala Gly 
        115                 120                 125             


Ser Gly Arg Gly Ala Arg Ser Gly Glu Trp Gly Leu Ala Ala Ala Gly 
    130                 135                 140                 


Ala Trp Glu Thr Met His His Cys Lys Arg Tyr Arg Ser Pro Glu Pro 
145                 150                 155                 160 


Asp Pro Tyr Leu Ser Tyr Arg Trp Lys Arg Arg Arg Ser Tyr Ser Arg 
                165                 170                 175     


Glu His Glu Gly Arg Leu Arg Tyr Pro Ser Arg Arg Glu Pro Pro Pro 
            180                 185                 190         


Arg Arg Ser Arg Ser Arg Ser His Asp Arg Leu Pro Tyr Gln Arg Arg 
        195                 200                 205             


Tyr Arg Glu Arg Arg Asp Ser Asp Thr Tyr Arg Cys Glu Glu Arg Ser 
    210                 215                 220                 


Pro Ser Phe Gly Glu Asp Tyr Tyr Gly Pro Ser Arg Ser Arg His Arg 
225                 230                 235                 240 


Arg Arg Ser Arg Glu Arg Gly Pro Tyr Arg Thr Arg Lys His Ala His 
                245                 250                 255     


His Cys His Lys Arg Arg Thr Arg Ser Cys Ser Ser Ala Ser Ser Arg 
            260                 265                 270         


Ser Gln Gln Ser Ser Lys Arg Ser Ser Arg Ser Val Glu Asp Asp Lys 
        275                 280                 285             


Glu Gly His Leu Val Cys Arg Ile Gly Asp Trp Leu Gln Glu Arg Tyr 
    290                 295                 300                 


Glu Ile Val Gly Asn Leu Gly Glu Gly Thr Phe Gly Lys Val Val Glu 
305                 310                 315                 320 


Cys Leu Asp His Ala Arg Gly Lys Ser Gln Val Ala Leu Lys Ile Ile 
                325                 330                 335     


Arg Asn Val Gly Lys Tyr Arg Glu Ala Ala Arg Leu Glu Ile Asn Val 
            340                 345                 350         


Leu Lys Lys Ile Lys Glu Lys Asp Lys Glu Asn Lys Phe Leu Cys Val 
        355                 360                 365             


Leu Met Ser Asp Trp Phe Asn Phe His Gly His Met Cys Ile Ala Phe 
    370                 375                 380                 


Glu Leu Leu Gly Lys Asn Thr Phe Glu Phe Leu Lys Glu Asn Asn Phe 
385                 390                 395                 400 


Gln Pro Tyr Pro Leu Pro His Val Arg His Met Ala Tyr Gln Leu Cys 
                405                 410                 415     


His Ala Leu Arg Phe Leu His Glu Asn Gln Leu Thr His Thr Asp Leu 
            420                 425                 430         


Lys Pro Glu Asn Ile Leu Phe Val Asn Ser Glu Phe Glu Thr Leu Tyr 
        435                 440                 445             


Asn Glu His Lys Ser Cys Glu Glu Lys Ser Val Lys Asn Thr Ser Ile 
    450                 455                 460                 


Arg Val Ala Asp Phe Gly Ser Ala Thr Phe Asp His Glu His His Thr 
465                 470                 475                 480 


Thr Ile Val Ala Thr Arg His Tyr Arg Pro Pro Glu Val Ile Leu Glu 
                485                 490                 495     


Leu Gly Trp Ala Gln Pro Cys Asp Val Trp Ser Ile Gly Cys Ile Leu 
            500                 505                 510         


Phe Glu Tyr Tyr Arg Gly Phe Thr Leu Phe Gln Thr His Glu Asn Arg 
        515                 520                 525             


Glu His Leu Val Met Met Glu Lys Ile Leu Gly Pro Ile Pro Ser His 
    530                 535                 540                 


Met Ile His Arg Thr Arg Lys Gln Lys Tyr Phe Tyr Lys Gly Gly Leu 
545                 550                 555                 560 


Val Trp Asp Glu Asn Ser Ser Asp Gly Arg Tyr Val Lys Glu Asn Cys 
                565                 570                 575     


Lys Pro Leu Lys Ser Tyr Met Leu Gln Asp Ser Leu Glu His Val Gln 
            580                 585                 590         


Leu Phe Asp Leu Met Arg Arg Met Leu Glu Phe Asp Pro Ala Gln Arg 
        595                 600                 605             


Ile Thr Leu Ala Glu Ala Leu Leu His Pro Phe Phe Ala Gly Leu Thr 
    610                 615                 620                 


Pro Glu Glu Arg Ser Phe His Thr Ser Arg Asn Pro Ser Arg 
625                 630                 635             


<210>  14
<211>  1918
<212>  DNA
<213>  Artificial

<220>
<223>  Human CLK3 cDNA isoform 1

<400>  14
aatgcccgtc ctctccgcgc gcaggaggga gttggcggac cacgcggggt cggggcgacg       60

gagcgggccc agccccacgg ccaggtcggg gccccacctc tcggctctga gagcccagcc      120

ggcccgggcc gcgcacctgt caggtcgggg gacctacgtg cgccgcgaca cggcgggagg      180

cgggccgggc caggctcgtc ccctcggccc tcccggaact agtctcctag gccgcggcgc      240

ccgccggagc ggagagggct ggtgccccgg agccttcgag tcgggggcta gagcggccag      300

gcctccgagc cgggtcgagc cgaggctggc gacggctgcg tcacgcgagg gggcggggct      360

gccacgggcg gaggtcgcag ccggaagcgg aagaggcgct cggagcgggg agtggggcct      420

agctgcagcc ggagcctggg agacgatgca tcactgtaag cgataccgct cccctgaacc      480

agacccgtac ctgagctacc gatggaagag gaggaggtcc tacagtcggg aacatgaagg      540

gagactgcga tacccgtccc gaagggagcc tcccccacga agatctcggt ccagaagcca      600

tgaccgcctg ccctaccaga ggaggtaccg ggagcgccgt gacagcgata cataccggtg      660

tgaagagcgg agcccatcct ttggagagga ctactatgga ccttcacgtt ctcgtcatcg      720

tcggcgatcg cgggagaggg ggccataccg gacccgcaag catgcccacc actgccacaa      780

acgccgcacc aggtcttgta gcagcgcctc ctcgagaagc caacagagca gtaagcgcag      840

cagccggagt gtggaagatg acaaggaggg tcacctggtg tgccggatcg gcgattggct      900

ccaagagcga tatgagattg tggggaacct gggtgaaggc acctttggca aggtggtgga      960

gtgcttggac catgccagag ggaagtctca ggttgccctg aagatcatcc gcaacgtggg     1020

caagtaccgg gaggctgccc ggctagaaat caacgtgctc aaaaaaatca aggagaagga     1080

caaagaaaac aagttcctgt gtgtcttgat gtctgactgg ttcaacttcc acggtcacat     1140

gtgcatcgcc tttgagctcc tgggcaagaa cacctttgag ttcctgaagg agaataactt     1200

ccagccttac cccctaccac atgtccggca catggcctac cagctctgcc acgcccttag     1260

atttctgcat gagaatcagc tgacccatac agacttgaaa ccagagaaca tcctgtttgt     1320

gaattctgag tttgaaaccc tctacaatga gcacaagagc tgtgaggaga agtcagtgaa     1380

gaacaccagc atccgagtgg ctgactttgg cagtgccaca tttgaccatg agcaccacac     1440

caccattgtg gccacccgtc actatcgccc gcctgaggtg atccttgagc tgggctgggc     1500

acagccctgt gacgtctgga gcattggctg cattctcttt gagtactacc ggggcttcac     1560

actcttccag acccacgaaa accgagagca cctggtgatg atggagaaga tcctagggcc     1620

catcccatca cacatgatcc accgtaccag gaagcagaaa tatttctaca aagggggcct     1680

agtttgggat gagaacagct ctgacggccg gtatgtgaag gagaactgca aacctctgaa     1740

gagttacatg ctccaagact ccctggagca cgtgcagctg tttgacctga tgaggaggat     1800

gttagaattt gaccctgccc agcgcatcac actggccgag gccctgctgc accccttctt     1860

tgctggcctg acccctgagg agcggtcctt ccacaccagc cgcaacccaa gcagatga       1918


<210>  15
<211>  490
<212>  PRT
<213>  Artificial

<220>
<223>  Human CLK3 protein isoform 2

<400>  15

Met His His Cys Lys Arg Tyr Arg Ser Pro Glu Pro Asp Pro Tyr Leu 
1               5                   10                  15      


Ser Tyr Arg Trp Lys Arg Arg Arg Ser Tyr Ser Arg Glu His Glu Gly 
            20                  25                  30          


Arg Leu Arg Tyr Pro Ser Arg Arg Glu Pro Pro Pro Arg Arg Ser Arg 
        35                  40                  45              


Ser Arg Ser His Asp Arg Leu Pro Tyr Gln Arg Arg Tyr Arg Glu Arg 
    50                  55                  60                  


Arg Asp Ser Asp Thr Tyr Arg Cys Glu Glu Arg Ser Pro Ser Phe Gly 
65                  70                  75                  80  


Glu Asp Tyr Tyr Gly Pro Ser Arg Ser Arg His Arg Arg Arg Ser Arg 
                85                  90                  95      


Glu Arg Gly Pro Tyr Arg Thr Arg Lys His Ala His His Cys His Lys 
            100                 105                 110         


Arg Arg Thr Arg Ser Cys Ser Ser Ala Ser Ser Arg Ser Gln Gln Ser 
        115                 120                 125             


Ser Lys Arg Ser Ser Arg Ser Val Glu Asp Asp Lys Glu Gly His Leu 
    130                 135                 140                 


Val Cys Arg Ile Gly Asp Trp Leu Gln Glu Arg Tyr Glu Ile Val Gly 
145                 150                 155                 160 


Asn Leu Gly Glu Gly Thr Phe Gly Lys Val Val Glu Cys Leu Asp His 
                165                 170                 175     


Ala Arg Gly Lys Ser Gln Val Ala Leu Lys Ile Ile Arg Asn Val Gly 
            180                 185                 190         


Lys Tyr Arg Glu Ala Ala Arg Leu Glu Ile Asn Val Leu Lys Lys Ile 
        195                 200                 205             


Lys Glu Lys Asp Lys Glu Asn Lys Phe Leu Cys Val Leu Met Ser Asp 
    210                 215                 220                 


Trp Phe Asn Phe His Gly His Met Cys Ile Ala Phe Glu Leu Leu Gly 
225                 230                 235                 240 


Lys Asn Thr Phe Glu Phe Leu Lys Glu Asn Asn Phe Gln Pro Tyr Pro 
                245                 250                 255     


Leu Pro His Val Arg His Met Ala Tyr Gln Leu Cys His Ala Leu Arg 
            260                 265                 270         


Phe Leu His Glu Asn Gln Leu Thr His Thr Asp Leu Lys Pro Glu Asn 
        275                 280                 285             


Ile Leu Phe Val Asn Ser Glu Phe Glu Thr Leu Tyr Asn Glu His Lys 
    290                 295                 300                 


Ser Cys Glu Glu Lys Ser Val Lys Asn Thr Ser Ile Arg Val Ala Asp 
305                 310                 315                 320 


Phe Gly Ser Ala Thr Phe Asp His Glu His His Thr Thr Ile Val Ala 
                325                 330                 335     


Thr Arg His Tyr Arg Pro Pro Glu Val Ile Leu Glu Leu Gly Trp Ala 
            340                 345                 350         


Gln Pro Cys Asp Val Trp Ser Ile Gly Cys Ile Leu Phe Glu Tyr Tyr 
        355                 360                 365             


Arg Gly Phe Thr Leu Phe Gln Thr His Glu Asn Arg Glu His Leu Val 
    370                 375                 380                 


Met Met Glu Lys Ile Leu Gly Pro Ile Pro Ser His Met Ile His Arg 
385                 390                 395                 400 


Thr Arg Lys Gln Lys Tyr Phe Tyr Lys Gly Gly Leu Val Trp Asp Glu 
                405                 410                 415     


Asn Ser Ser Asp Gly Arg Tyr Val Lys Glu Asn Cys Lys Pro Leu Lys 
            420                 425                 430         


Ser Tyr Met Leu Gln Asp Ser Leu Glu His Val Gln Leu Phe Asp Leu 
        435                 440                 445             


Met Arg Arg Met Leu Glu Phe Asp Pro Ala Gln Arg Ile Thr Leu Ala 
    450                 455                 460                 


Glu Ala Leu Leu His Pro Phe Phe Ala Gly Leu Thr Pro Glu Glu Arg 
465                 470                 475                 480 


Ser Phe His Thr Ser Arg Asn Pro Ser Arg 
                485                 490 


<210>  16
<211>  1473
<212>  DNA
<213>  Artificial

<220>
<223>  Human CLK3 cDNA isoform 2

<400>  16
atgcatcact gtaagcgata ccgctcccct gaaccagacc cgtacctgag ctaccgatgg       60

aagaggagga ggtcctacag tcgggaacat gaagggagac tgcgataccc gtcccgaagg      120

gagcctcccc cacgaagatc tcggtccaga agccatgacc gcctgcccta ccagaggagg      180

taccgggagc gccgtgacag cgatacatac cggtgtgaag agcggagccc atcctttgga      240

gaggactact atggaccttc acgttctcgt catcgtcggc gatcgcggga gagggggcca      300

taccggaccc gcaagcatgc ccaccactgc cacaaacgcc gcaccaggtc ttgtagcagc      360

gcctcctcga gaagccaaca gagcagtaag cgcagcagcc ggagtgtgga agatgacaag      420

gagggtcacc tggtgtgccg gatcggcgat tggctccaag agcgatatga gattgtgggg      480

aacctgggtg aaggcacctt tggcaaggtg gtggagtgct tggaccatgc cagagggaag      540

tctcaggttg ccctgaagat catccgcaac gtgggcaagt accgggaggc tgcccggcta      600

gaaatcaacg tgctcaaaaa aatcaaggag aaggacaaag aaaacaagtt cctgtgtgtc      660

ttgatgtctg actggttcaa cttccacggt cacatgtgca tcgcctttga gctcctgggc      720

aagaacacct ttgagttcct gaaggagaat aacttccagc cttaccccct accacatgtc      780

cggcacatgg cctaccagct ctgccacgcc cttagatttc tgcatgagaa tcagctgacc      840

catacagact tgaaaccaga gaacatcctg tttgtgaatt ctgagtttga aaccctctac      900

aatgagcaca agagctgtga ggagaagtca gtgaagaaca ccagcatccg agtggctgac      960

tttggcagtg ccacatttga ccatgagcac cacaccacca ttgtggccac ccgtcactat     1020

cgcccgcctg aggtgatcct tgagctgggc tgggcacagc cctgtgacgt ctggagcatt     1080

ggctgcattc tctttgagta ctaccggggc ttcacactct tccagaccca cgaaaaccga     1140

gagcacctgg tgatgatgga gaagatccta gggcccatcc catcacacat gatccaccgt     1200

accaggaagc agaaatattt ctacaaaggg ggcctagttt gggatgagaa cagctctgac     1260

ggccggtatg tgaaggagaa ctgcaaacct ctgaagagtt acatgctcca agactccctg     1320

gagcacgtgc agctgtttga cctgatgagg aggatgttag aatttgaccc tgcccagcgc     1380

atcacactgg ccgaggccct gctgcacccc ttctttgctg gcctgacccc tgaggagcgg     1440

tccttccaca ccagccgcaa cccaagcaga tga                                  1473


<210>  17
<211>  481
<212>  PRT
<213>  Artificial

<220>
<223>  Human CLK4 protein

<400>  17

Met Arg His Ser Lys Arg Thr His Cys Pro Asp Trp Asp Ser Arg Glu 
1               5                   10                  15      


Ser Trp Gly His Glu Ser Tyr Arg Gly Ser His Lys Arg Lys Arg Arg 
            20                  25                  30          


Ser His Ser Ser Thr Gln Glu Asn Arg His Cys Lys Pro His His Gln 
        35                  40                  45              


Phe Lys Glu Ser Asp Cys His Tyr Leu Glu Ala Arg Ser Leu Asn Glu 
    50                  55                  60                  


Arg Asp Tyr Arg Asp Arg Arg Tyr Val Asp Glu Tyr Arg Asn Asp Tyr 
65                  70                  75                  80  


Cys Glu Gly Tyr Val Pro Arg His Tyr His Arg Asp Ile Glu Ser Gly 
                85                  90                  95      


Tyr Arg Ile His Cys Ser Lys Ser Ser Val Arg Ser Arg Arg Ser Ser 
            100                 105                 110         


Pro Lys Arg Lys Arg Asn Arg His Cys Ser Ser His Gln Ser Arg Ser 
        115                 120                 125             


Lys Ser His Arg Arg Lys Arg Ser Arg Ser Ile Glu Asp Asp Glu Glu 
    130                 135                 140                 


Gly His Leu Ile Cys Gln Ser Gly Asp Val Leu Arg Ala Arg Tyr Glu 
145                 150                 155                 160 


Ile Val Asp Thr Leu Gly Glu Gly Ala Phe Gly Lys Val Val Glu Cys 
                165                 170                 175     


Ile Asp His Gly Met Asp Gly Met His Val Ala Val Lys Ile Val Lys 
            180                 185                 190         


Asn Val Gly Arg Tyr Arg Glu Ala Ala Arg Ser Glu Ile Gln Val Leu 
        195                 200                 205             


Glu His Leu Asn Ser Thr Asp Pro Asn Ser Val Phe Arg Cys Val Gln 
    210                 215                 220                 


Met Leu Glu Trp Phe Asp His His Gly His Val Cys Ile Val Phe Glu 
225                 230                 235                 240 


Leu Leu Gly Leu Ser Thr Tyr Asp Phe Ile Lys Glu Asn Ser Phe Leu 
                245                 250                 255     


Pro Phe Gln Ile Asp His Ile Arg Gln Met Ala Tyr Gln Ile Cys Gln 
            260                 265                 270         


Ser Ile Asn Phe Leu His His Asn Lys Leu Thr His Thr Asp Leu Lys 
        275                 280                 285             


Pro Glu Asn Ile Leu Phe Val Lys Ser Asp Tyr Val Val Lys Tyr Asn 
    290                 295                 300                 


Ser Lys Met Lys Arg Asp Glu Arg Thr Leu Lys Asn Thr Asp Ile Lys 
305                 310                 315                 320 


Val Val Asp Phe Gly Ser Ala Thr Tyr Asp Asp Glu His His Ser Thr 
                325                 330                 335     


Leu Val Ser Thr Arg His Tyr Arg Ala Pro Glu Val Ile Leu Ala Leu 
            340                 345                 350         


Gly Trp Ser Gln Pro Cys Asp Val Trp Ser Ile Gly Cys Ile Leu Ile 
        355                 360                 365             


Glu Tyr Tyr Leu Gly Phe Thr Val Phe Gln Thr His Asp Ser Lys Glu 
    370                 375                 380                 


His Leu Ala Met Met Glu Arg Ile Leu Gly Pro Ile Pro Gln His Met 
385                 390                 395                 400 


Ile Gln Lys Thr Arg Lys Arg Lys Tyr Phe His His Asn Gln Leu Asp 
                405                 410                 415     


Trp Asp Glu His Ser Ser Ala Gly Arg Tyr Val Arg Arg Arg Cys Lys 
            420                 425                 430         


Pro Leu Lys Glu Phe Met Leu Cys His Asp Glu Glu His Glu Lys Leu 
        435                 440                 445             


Phe Asp Leu Val Arg Arg Met Leu Glu Tyr Asp Pro Thr Gln Arg Ile 
    450                 455                 460                 


Thr Leu Asp Glu Ala Leu Gln His Pro Phe Phe Asp Leu Leu Lys Lys 
465                 470                 475                 480 


Lys 
    


<210>  18
<211>  1446
<212>  DNA
<213>  Artificial

<220>
<223>  Human CLK4

<400>  18
atgcggcatt ccaaaagaac tcactgtcct gattgggata gcagagaaag ctggggacat       60

gaaagctatc gtggaagtca caagcggaag aggagatctc atagtagcac acaagagaac      120

aggcattgta aaccacatca ccagtttaaa gaatctgatt gtcattattt agaagcaagg      180

tccttgaatg agcgagatta tcgggaccgg agatacgttg acgaatacag gaatgactac      240

tgtgaaggat atgttcctag acattatcac agagacattg aaagcgggta tcgaatccac      300

tgcagtaaat cttcagtccg cagcaggaga agcagtccta aaaggaagcg caatagacac      360

tgttcaagtc atcagtcacg ttcgaagagc caccgaagga aaagatccag gagtatagag      420

gatgatgagg agggtcacct gatctgtcaa agtggagacg ttctaagagc aagatatgaa      480

atcgtggaca ctttgggtga aggagccttt ggcaaagttg tagagtgcat tgatcatggc      540

atggatggca tgcatgtagc agtgaaaatc gtaaaaaatg taggccgtta ccgtgaagca      600

gctcgttcag aaatccaagt attagagcac ttaaatagta ctgatcccaa tagtgtcttc      660

cgatgtgtcc agatgctaga atggtttgat catcatggtc atgtttgtat tgtgtttgaa      720

ctactgggac ttagtactta cgatttcatt aaagaaaaca gctttctgcc atttcaaatt      780

gaccacatca ggcagatggc gtatcagatc tgccagtcaa taaatttttt acatcataat      840

aaattaaccc atacagatct gaagcctgaa aatattttgt ttgtgaagtc tgactatgta      900

gtcaaatata attctaaaat gaaacgtgat gaacgcacac tgaaaaacac agatatcaaa      960

gttgttgact ttggaagtgc aacgtatgat gatgaacatc acagtacttt ggtgtctacc     1020

cggcactaca gagctcccga ggtcattttg gctttaggtt ggtctcagcc ttgtgatgtt     1080

tggagcatag gttgcattct tattgaatat taccttggtt tcacagtctt tcagactcat     1140

gatagtaaag agcacctggc aatgatggaa cgaatattag gacccatacc acaacacatg     1200

attcagaaaa caagaaaacg caagtatttt caccataacc agctagattg ggatgaacac     1260

agttctgctg gtagatatgt taggagacgc tgcaaaccgt tgaaggaatt tatgctttgt     1320

catgatgaag aacatgagaa actgtttgac ctggttcgaa gaatgttaga atatgatcca     1380

actcaaagaa ttaccttgga tgaagcattg cagcatcctt tctttgactt attaaaaaag     1440

aaatga                                                                1446


<210>  19
<211>  763
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK1A protein long isoform

<400>  19

Met His Thr Gly Gly Glu Thr Ser Ala Cys Lys Pro Ser Ser Val Arg 
1               5                   10                  15      


Leu Ala Pro Ser Phe Ser Phe His Ala Ala Gly Leu Gln Met Ala Gly 
            20                  25                  30          


Gln Met Pro His Ser His Gln Tyr Ser Asp Arg Arg Gln Pro Asn Ile 
        35                  40                  45              


Ser Asp Gln Gln Val Ser Ala Leu Ser Tyr Ser Asp Gln Ile Gln Gln 
    50                  55                  60                  


Pro Leu Thr Asn Gln Val Met Pro Asp Ile Val Met Leu Gln Arg Arg 
65                  70                  75                  80  


Met Pro Gln Thr Phe Arg Asp Pro Ala Thr Ala Pro Leu Arg Lys Leu 
                85                  90                  95      


Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr 
            100                 105                 110         


Ala Lys Lys Lys Arg Arg His Gln Gln Gly Gln Gly Asp Asp Ser Ser 
        115                 120                 125             


His Lys Lys Glu Arg Lys Val Tyr Asn Asp Gly Tyr Asp Asp Asp Asn 
    130                 135                 140                 


Tyr Asp Tyr Ile Val Lys Asn Gly Glu Lys Trp Met Asp Arg Tyr Glu 
145                 150                 155                 160 


Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala 
                165                 170                 175     


Tyr Asp Arg Val Glu Gln Glu Trp Val Ala Ile Lys Ile Ile Lys Asn 
            180                 185                 190         


Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Val Arg Leu Leu Glu 
        195                 200                 205             


Leu Met Asn Lys His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu 
    210                 215                 220                 


Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Met 
225                 230                 235                 240 


Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr Asn Phe Arg Gly 
                245                 250                 255     


Val Ser Leu Asn Leu Thr Arg Lys Phe Ala Gln Gln Met Cys Thr Ala 
            260                 265                 270         


Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu 
        275                 280                 285             


Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys 
    290                 295                 300                 


Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln 
305                 310                 315                 320 


Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Met 
                325                 330                 335     


Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val 
            340                 345                 350         


Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ala Asn Glu Val Asp 
        355                 360                 365             


Gln Met Asn Lys Ile Val Glu Val Leu Gly Ile Pro Pro Ala His Ile 
    370                 375                 380                 


Leu Asp Gln Ala Pro Lys Ala Arg Lys Phe Phe Glu Lys Leu Pro Asp 
385                 390                 395                 400 


Gly Thr Trp Asn Leu Lys Lys Thr Lys Asp Gly Lys Arg Glu Tyr Lys 
                405                 410                 415     


Pro Pro Gly Thr Arg Lys Leu His Asn Ile Leu Gly Val Glu Thr Gly 
            420                 425                 430         


Gly Pro Gly Gly Arg Arg Ala Gly Glu Ser Gly His Thr Val Ala Asp 
        435                 440                 445             


Tyr Leu Lys Phe Lys Asp Leu Ile Leu Arg Met Leu Asp Tyr Asp Pro 
    450                 455                 460                 


Lys Thr Arg Ile Gln Pro Tyr Tyr Ala Leu Gln His Ser Phe Phe Lys 
465                 470                 475                 480 


Lys Thr Ala Asp Glu Gly Thr Asn Thr Ser Asn Ser Val Ser Thr Ser 
                485                 490                 495     


Pro Ala Met Glu Gln Ser Gln Ser Ser Gly Thr Thr Ser Ser Thr Ser 
            500                 505                 510         


Ser Ser Ser Gly Gly Ser Ser Gly Thr Ser Asn Ser Gly Arg Ala Arg 
        515                 520                 525             


Ser Asp Pro Thr His Gln His Arg His Ser Gly Gly His Phe Thr Ala 
    530                 535                 540                 


Ala Val Gln Ala Met Asp Cys Glu Thr His Ser Pro Gln Val Arg Gln 
545                 550                 555                 560 


Gln Phe Pro Ala Pro Leu Gly Trp Ser Gly Thr Glu Ala Pro Thr Gln 
                565                 570                 575     


Val Thr Val Glu Thr His Pro Val Gln Glu Thr Thr Phe His Val Ala 
            580                 585                 590         


Pro Gln Gln Asn Ala Leu His His His His Gly Asn Ser Ser His His 
        595                 600                 605             


His His His His His His His His His His His Gly Gln Gln Ala Leu 
    610                 615                 620                 


Gly Asn Arg Thr Arg Pro Arg Val Tyr Asn Ser Pro Thr Asn Ser Ser 
625                 630                 635                 640 


Ser Thr Gln Asp Ser Met Glu Val Gly His Ser His His Ser Met Thr 
                645                 650                 655     


Ser Leu Ser Ser Ser Thr Thr Ser Ser Ser Thr Ser Ser Ser Ser Thr 
            660                 665                 670         


Gly Asn Gln Gly Asn Gln Ala Tyr Gln Asn Arg Pro Val Ala Ala Asn 
        675                 680                 685             


Thr Leu Asp Phe Gly Gln Asn Gly Ala Met Asp Val Asn Leu Thr Val 
    690                 695                 700                 


Tyr Ser Asn Pro Arg Gln Glu Thr Gly Ile Ala Gly His Pro Thr Tyr 
705                 710                 715                 720 


Gln Phe Ser Ala Asn Thr Gly Pro Ala His Tyr Met Thr Glu Gly His 
                725                 730                 735     


Leu Thr Met Arg Gln Gly Ala Asp Arg Glu Glu Ser Pro Met Thr Gly 
            740                 745                 750         


Val Cys Val Gln Gln Ser Pro Val Ala Ser Ser 
        755                 760             


<210>  20
<211>  2292
<212>  DNA
<213>  Artificial

<220>
<223>  Human DYRK1A cDNA long isoform

<400>  20
atgcatacag gaggagagac ttcagcatgc aaaccttcat ctgttcggct tgcaccgtca       60

ttttcattcc atgctgctgg ccttcagatg gctggacaga tgccccattc acatcagtac      120

agtgaccgtc gccagccaaa cataagtgac caacaggttt ctgccttatc atattctgac      180

cagattcagc aacctctaac taaccaggtg atgcctgata ttgtcatgtt acagaggcgg      240

atgccccaaa ccttccgtga cccagcaact gctcccctga gaaaactttc tgttgacttg      300

atcaaaacat acaagcatat taatgaggtt tactatgcaa aaaagaagcg aagacaccaa      360

cagggccagg gagacgattc tagtcataag aaggaacgga aggtttacaa tgatggttat      420

gatgatgata actatgatta tattgtaaaa aacggagaaa agtggatgga tcgttacgaa      480

attgactcct tgataggcaa aggttccttt ggacaggttg taaaggcata tgatcgtgtg      540

gagcaagaat gggttgccat taaaataata aagaacaaga aggcttttct gaatcaagca      600

cagatagaag tgcgacttct tgagctcatg aacaaacatg acactgaaat gaaatactac      660

atagtgcatt tgaaacgcca ctttatgttt cgaaaccatc tctgtttagt ttttgaaatg      720

ctgtcctaca acctctatga cttgctgaga aacaccaatt tccgaggggt ctctttgaac      780

ctaacacgaa agtttgcgca acagatgtgc actgcactgc ttttccttgc gactccagaa      840

cttagtatca ttcactgtga tctaaaacct gaaaatatcc ttctttgtaa ccccaaacgc      900

agtgcaatca agatagttga ctttggcagt tcttgtcagt tggggcagag gatataccag      960

tatattcaga gtcgctttta tcggtctcca gaggtgctac tgggaatgcc ttatgacctt     1020

gccattgata tgtggtccct cgggtgtatt ttggttgaaa tgcacactgg agaacctctg     1080

ttcagtggtg ccaatgaggt agatcagatg aataaaatag tggaagttct gggtattcca     1140

cctgctcata ttcttgacca agcaccaaaa gcaagaaagt tctttgagaa gttgccagat     1200

ggcacttgga acttaaagaa gaccaaagat ggaaaacggg agtacaaacc accaggaacc     1260

cgtaaacttc ataacattct tggagtggaa acaggaggac ctggtgggcg acgtgctggg     1320

gagtcaggtc atacggtcgc tgactacttg aagttcaaag acctcatttt aaggatgctt     1380

gattatgacc ccaaaactcg aattcaacct tattatgctc tgcagcacag tttcttcaag     1440

aaaacagctg atgaaggtac aaatacaagt aatagtgtat ctacaagccc cgccatggag     1500

cagtctcagt cttcgggcac cacctccagt acatcgtcaa gctcaggtgg ctcatcgggg     1560

acaagcaaca gtgggagagc ccggtcggat ccgacgcacc agcatcggca cagtggtggg     1620

cacttcacag ctgccgtgca ggccatggac tgcgagacac acagtcccca ggtgcgtcag     1680

caatttcctg ctcctcttgg ttggtcaggc actgaagctc ctacacaggt cactgttgaa     1740

actcatcctg ttcaagaaac aacctttcat gtagcccctc aacagaatgc attgcatcat     1800

caccatggta acagttccca tcaccatcac caccaccacc accatcacca ccaccatgga     1860

caacaagcct tgggtaaccg gaccaggcca agggtctaca attctccaac gaatagctcc     1920

tctacccaag attctatgga ggttggccac agtcaccact ccatgacatc cctgtcttcc     1980

tcaacgactt cttcctcgac atcttcctcc tctactggta accaaggcaa tcaggcctac     2040

cagaatcgcc cagtggctgc taataccttg gactttggac agaatggagc tatggacgtt     2100

aatttgaccg tctactccaa tccccgccaa gagactggca tagctggaca tccaacatac     2160

caattttctg ctaatacagg tcctgcacat tacatgactg aaggacatct gacaatgagg     2220

caaggggctg atagagaaga gtcccccatg acaggagttt gtgtgcaaca gagtcctgta     2280

gctagctcgt ga                                                         2292


<210>  21
<211>  754
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK1A protein isoform 1

<400>  21

Met His Thr Gly Gly Glu Thr Ser Ala Cys Lys Pro Ser Ser Val Arg 
1               5                   10                  15      


Leu Ala Pro Ser Phe Ser Phe His Ala Ala Gly Leu Gln Met Ala Gly 
            20                  25                  30          


Gln Met Pro His Ser His Gln Tyr Ser Asp Arg Arg Gln Pro Asn Ile 
        35                  40                  45              


Ser Asp Gln Gln Val Ser Ala Leu Ser Tyr Ser Asp Gln Ile Gln Gln 
    50                  55                  60                  


Pro Leu Thr Asn Gln Arg Arg Met Pro Gln Thr Phe Arg Asp Pro Ala 
65                  70                  75                  80  


Thr Ala Pro Leu Arg Lys Leu Ser Val Asp Leu Ile Lys Thr Tyr Lys 
                85                  90                  95      


His Ile Asn Glu Val Tyr Tyr Ala Lys Lys Lys Arg Arg His Gln Gln 
            100                 105                 110         


Gly Gln Gly Asp Asp Ser Ser His Lys Lys Glu Arg Lys Val Tyr Asn 
        115                 120                 125             


Asp Gly Tyr Asp Asp Asp Asn Tyr Asp Tyr Ile Val Lys Asn Gly Glu 
    130                 135                 140                 


Lys Trp Met Asp Arg Tyr Glu Ile Asp Ser Leu Ile Gly Lys Gly Ser 
145                 150                 155                 160 


Phe Gly Gln Val Val Lys Ala Tyr Asp Arg Val Glu Gln Glu Trp Val 
                165                 170                 175     


Ala Ile Lys Ile Ile Lys Asn Lys Lys Ala Phe Leu Asn Gln Ala Gln 
            180                 185                 190         


Ile Glu Val Arg Leu Leu Glu Leu Met Asn Lys His Asp Thr Glu Met 
        195                 200                 205             


Lys Tyr Tyr Ile Val His Leu Lys Arg His Phe Met Phe Arg Asn His 
    210                 215                 220                 


Leu Cys Leu Val Phe Glu Met Leu Ser Tyr Asn Leu Tyr Asp Leu Leu 
225                 230                 235                 240 


Arg Asn Thr Asn Phe Arg Gly Val Ser Leu Asn Leu Thr Arg Lys Phe 
                245                 250                 255     


Ala Gln Gln Met Cys Thr Ala Leu Leu Phe Leu Ala Thr Pro Glu Leu 
            260                 265                 270         


Ser Ile Ile His Cys Asp Leu Lys Pro Glu Asn Ile Leu Leu Cys Asn 
        275                 280                 285             


Pro Lys Arg Ser Ala Ile Lys Ile Val Asp Phe Gly Ser Ser Cys Gln 
    290                 295                 300                 


Leu Gly Gln Arg Ile Tyr Gln Tyr Ile Gln Ser Arg Phe Tyr Arg Ser 
305                 310                 315                 320 


Pro Glu Val Leu Leu Gly Met Pro Tyr Asp Leu Ala Ile Asp Met Trp 
                325                 330                 335     


Ser Leu Gly Cys Ile Leu Val Glu Met His Thr Gly Glu Pro Leu Phe 
            340                 345                 350         


Ser Gly Ala Asn Glu Val Asp Gln Met Asn Lys Ile Val Glu Val Leu 
        355                 360                 365             


Gly Ile Pro Pro Ala His Ile Leu Asp Gln Ala Pro Lys Ala Arg Lys 
    370                 375                 380                 


Phe Phe Glu Lys Leu Pro Asp Gly Thr Trp Asn Leu Lys Lys Thr Lys 
385                 390                 395                 400 


Asp Gly Lys Arg Glu Tyr Lys Pro Pro Gly Thr Arg Lys Leu His Asn 
                405                 410                 415     


Ile Leu Gly Val Glu Thr Gly Gly Pro Gly Gly Arg Arg Ala Gly Glu 
            420                 425                 430         


Ser Gly His Thr Val Ala Asp Tyr Leu Lys Phe Lys Asp Leu Ile Leu 
        435                 440                 445             


Arg Met Leu Asp Tyr Asp Pro Lys Thr Arg Ile Gln Pro Tyr Tyr Ala 
    450                 455                 460                 


Leu Gln His Ser Phe Phe Lys Lys Thr Ala Asp Glu Gly Thr Asn Thr 
465                 470                 475                 480 


Ser Asn Ser Val Ser Thr Ser Pro Ala Met Glu Gln Ser Gln Ser Ser 
                485                 490                 495     


Gly Thr Thr Ser Ser Thr Ser Ser Ser Ser Gly Gly Ser Ser Gly Thr 
            500                 505                 510         


Ser Asn Ser Gly Arg Ala Arg Ser Asp Pro Thr His Gln His Arg His 
        515                 520                 525             


Ser Gly Gly His Phe Thr Ala Ala Val Gln Ala Met Asp Cys Glu Thr 
    530                 535                 540                 


His Ser Pro Gln Val Arg Gln Gln Phe Pro Ala Pro Leu Gly Trp Ser 
545                 550                 555                 560 


Gly Thr Glu Ala Pro Thr Gln Val Thr Val Glu Thr His Pro Val Gln 
                565                 570                 575     


Glu Thr Thr Phe His Val Ala Pro Gln Gln Asn Ala Leu His His His 
            580                 585                 590         


His Gly Asn Ser Ser His His His His His His His His His His His 
        595                 600                 605             


His His Gly Gln Gln Ala Leu Gly Asn Arg Thr Arg Pro Arg Val Tyr 
    610                 615                 620                 


Asn Ser Pro Thr Asn Ser Ser Ser Thr Gln Asp Ser Met Glu Val Gly 
625                 630                 635                 640 


His Ser His His Ser Met Thr Ser Leu Ser Ser Ser Thr Thr Ser Ser 
                645                 650                 655     


Ser Thr Ser Ser Ser Ser Thr Gly Asn Gln Gly Asn Gln Ala Tyr Gln 
            660                 665                 670         


Asn Arg Pro Val Ala Ala Asn Thr Leu Asp Phe Gly Gln Asn Gly Ala 
        675                 680                 685             


Met Asp Val Asn Leu Thr Val Tyr Ser Asn Pro Arg Gln Glu Thr Gly 
    690                 695                 700                 


Ile Ala Gly His Pro Thr Tyr Gln Phe Ser Ala Asn Thr Gly Pro Ala 
705                 710                 715                 720 


His Tyr Met Thr Glu Gly His Leu Thr Met Arg Gln Gly Ala Asp Arg 
                725                 730                 735     


Glu Glu Ser Pro Met Thr Gly Val Cys Val Gln Gln Ser Pro Val Ala 
            740                 745                 750         


Ser Ser 
        


<210>  22
<211>  2265
<212>  DNA
<213>  Artificial

<220>
<223>  Human DYRK1A cDNA isoform 1

<400>  22
atgcatacag gaggagagac ttcagcatgc aaaccttcat ctgttcggct tgcaccgtca       60

ttttcattcc atgctgctgg ccttcagatg gctggacaga tgccccattc acatcagtac      120

agtgaccgtc gccagccaaa cataagtgac caacaggttt ctgccttatc atattctgac      180

cagattcagc aacctctaac taaccagagg cggatgcccc aaaccttccg tgacccagca      240

actgctcccc tgagaaaact ttctgttgac ttgatcaaaa catacaagca tattaatgag      300

gtttactatg caaaaaagaa gcgaagacac caacagggcc agggagacga ttctagtcat      360

aagaaggaac ggaaggttta caatgatggt tatgatgatg ataactatga ttatattgta      420

aaaaacggag aaaagtggat ggatcgttac gaaattgact ccttgatagg caaaggttcc      480

tttggacagg ttgtaaaggc atatgatcgt gtggagcaag aatgggttgc cattaaaata      540

ataaagaaca agaaggcttt tctgaatcaa gcacagatag aagtgcgact tcttgagctc      600

atgaacaaac atgacactga aatgaaatac tacatagtgc atttgaaacg ccactttatg      660

tttcgaaacc atctctgttt agtttttgaa atgctgtcct acaacctcta tgacttgctg      720

agaaacacca atttccgagg ggtctctttg aacctaacac gaaagtttgc gcaacagatg      780

tgcactgcac tgcttttcct tgcgactcca gaacttagta tcattcactg tgatctaaaa      840

cctgaaaata tccttctttg taaccccaaa cgcagtgcaa tcaagatagt tgactttggc      900

agttcttgtc agttggggca gaggatatac cagtatattc agagtcgctt ttatcggtct      960

ccagaggtgc tactgggaat gccttatgac cttgccattg atatgtggtc cctcgggtgt     1020

attttggttg aaatgcacac tggagaacct ctgttcagtg gtgccaatga ggtagatcag     1080

atgaataaaa tagtggaagt tctgggtatt ccacctgctc atattcttga ccaagcacca     1140

aaagcaagaa agttctttga gaagttgcca gatggcactt ggaacttaaa gaagaccaaa     1200

gatggaaaac gggagtacaa accaccagga acccgtaaac ttcataacat tcttggagtg     1260

gaaacaggag gacctggtgg gcgacgtgct ggggagtcag gtcatacggt cgctgactac     1320

ttgaagttca aagacctcat tttaaggatg cttgattatg accccaaaac tcgaattcaa     1380

ccttattatg ctctgcagca cagtttcttc aagaaaacag ctgatgaagg tacaaataca     1440

agtaatagtg tatctacaag ccccgccatg gagcagtctc agtcttcggg caccacctcc     1500

agtacatcgt caagctcagg tggctcatcg gggacaagca acagtgggag agcccggtcg     1560

gatccgacgc accagcatcg gcacagtggt gggcacttca cagctgccgt gcaggccatg     1620

gactgcgaga cacacagtcc ccaggtgcgt cagcaatttc ctgctcctct tggttggtca     1680

ggcactgaag ctcctacaca ggtcactgtt gaaactcatc ctgttcaaga aacaaccttt     1740

catgtagccc ctcaacagaa tgcattgcat catcaccatg gtaacagttc ccatcaccat     1800

caccaccacc accaccatca ccaccaccat ggacaacaag ccttgggtaa ccggaccagg     1860

ccaagggtct acaattctcc aacgaatagc tcctctaccc aagattctat ggaggttggc     1920

cacagtcacc actccatgac atccctgtct tcctcaacga cttcttcctc gacatcttcc     1980

tcctctactg gtaaccaagg caatcaggcc taccagaatc gcccagtggc tgctaatacc     2040

ttggactttg gacagaatgg agctatggac gttaatttga ccgtctactc caatccccgc     2100

caagagactg gcatagctgg acatccaaca taccaatttt ctgctaatac aggtcctgca     2160

cattacatga ctgaaggaca tctgacaatg aggcaagggg ctgatagaga agagtccccc     2220

atgacaggag tttgtgtgca acagagtcct gtagctagct cgtga                     2265


<210>  23
<211>  529
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK1A protein isoform 2

<400>  23

Met His Thr Gly Gly Glu Thr Ser Ala Cys Lys Pro Ser Ser Val Arg 
1               5                   10                  15      


Leu Ala Pro Ser Phe Ser Phe His Ala Ala Gly Leu Gln Met Ala Gly 
            20                  25                  30          


Gln Met Pro His Ser His Gln Tyr Ser Asp Arg Arg Gln Pro Asn Ile 
        35                  40                  45              


Ser Asp Gln Gln Val Ser Ala Leu Ser Tyr Ser Asp Gln Ile Gln Gln 
    50                  55                  60                  


Pro Leu Thr Asn Gln Val Met Pro Asp Ile Val Met Leu Gln Arg Arg 
65                  70                  75                  80  


Met Pro Gln Thr Phe Arg Asp Pro Ala Thr Ala Pro Leu Arg Lys Leu 
                85                  90                  95      


Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr 
            100                 105                 110         


Ala Lys Lys Lys Arg Arg His Gln Gln Gly Gln Gly Asp Asp Ser Ser 
        115                 120                 125             


His Lys Lys Glu Arg Lys Val Tyr Asn Asp Gly Tyr Asp Asp Asp Asn 
    130                 135                 140                 


Tyr Asp Tyr Ile Val Lys Asn Gly Glu Lys Trp Met Asp Arg Tyr Glu 
145                 150                 155                 160 


Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala 
                165                 170                 175     


Tyr Asp Arg Val Glu Gln Glu Trp Val Ala Ile Lys Ile Ile Lys Asn 
            180                 185                 190         


Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Val Arg Leu Leu Glu 
        195                 200                 205             


Leu Met Asn Lys His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu 
    210                 215                 220                 


Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Met 
225                 230                 235                 240 


Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr Asn Phe Arg Gly 
                245                 250                 255     


Val Ser Leu Asn Leu Thr Arg Lys Phe Ala Gln Gln Met Cys Thr Ala 
            260                 265                 270         


Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu 
        275                 280                 285             


Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys 
    290                 295                 300                 


Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln 
305                 310                 315                 320 


Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Met 
                325                 330                 335     


Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val 
            340                 345                 350         


Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ala Asn Glu Val Asp 
        355                 360                 365             


Gln Met Asn Lys Ile Val Glu Val Leu Gly Ile Pro Pro Ala His Ile 
    370                 375                 380                 


Leu Asp Gln Ala Pro Lys Ala Arg Lys Phe Phe Glu Lys Leu Pro Asp 
385                 390                 395                 400 


Gly Thr Trp Asn Leu Lys Lys Thr Lys Asp Gly Lys Arg Glu Tyr Lys 
                405                 410                 415     


Pro Pro Gly Thr Arg Lys Leu His Asn Ile Leu Gly Val Glu Thr Gly 
            420                 425                 430         


Gly Pro Gly Gly Arg Arg Ala Gly Glu Ser Gly His Thr Val Ala Asp 
        435                 440                 445             


Tyr Leu Lys Phe Lys Asp Leu Ile Leu Arg Met Leu Asp Tyr Asp Pro 
    450                 455                 460                 


Lys Thr Arg Ile Gln Pro Tyr Tyr Ala Leu Gln His Ser Phe Phe Lys 
465                 470                 475                 480 


Lys Thr Ala Asp Glu Gly Thr Asn Thr Ser Asn Ser Val Ser Thr Ser 
                485                 490                 495     


Pro Ala Met Glu Gln Ser Gln Ser Ser Gly Thr Thr Ser Ser Thr Ser 
            500                 505                 510         


Ser Ser Ser Gly Ala Ser Ala Ile Ser Cys Ser Ser Trp Leu Val Arg 
        515                 520                 525             


His 
    


<210>  24
<211>  1590
<212>  DNA
<213>  Artificial

<220>
<223>  Human DYRK1A cDNA isoform 2

<400>  24
atgcatacag gaggagagac ttcagcatgc aaaccttcat ctgttcggct tgcaccgtca       60

ttttcattcc atgctgctgg ccttcagatg gctggacaga tgccccattc acatcagtac      120

agtgaccgtc gccagccaaa cataagtgac caacaggttt ctgccttatc atattctgac      180

cagattcagc aacctctaac taaccaggtg atgcctgata ttgtcatgtt acagaggcgg      240

atgccccaaa ccttccgtga cccagcaact gctcccctga gaaaactttc tgttgacttg      300

atcaaaacat acaagcatat taatgaggtt tactatgcaa aaaagaagcg aagacaccaa      360

cagggccagg gagacgattc tagtcataag aaggaacgga aggtttacaa tgatggttat      420

gatgatgata actatgatta tattgtaaaa aacggagaaa agtggatgga tcgttacgaa      480

attgactcct tgataggcaa aggttccttt ggacaggttg taaaggcata tgatcgtgtg      540

gagcaagaat gggttgccat taaaataata aagaacaaga aggcttttct gaatcaagca      600

cagatagaag tgcgacttct tgagctcatg aacaaacatg acactgaaat gaaatactac      660

atagtgcatt tgaaacgcca ctttatgttt cgaaaccatc tctgtttagt ttttgaaatg      720

ctgtcctaca acctctatga cttgctgaga aacaccaatt tccgaggggt ctctttgaac      780

ctaacacgaa agtttgcgca acagatgtgc actgcactgc ttttccttgc gactccagaa      840

cttagtatca ttcactgtga tctaaaacct gaaaatatcc ttctttgtaa ccccaaacgc      900

agtgcaatca agatagttga ctttggcagt tcttgtcagt tggggcagag gatataccag      960

tatattcaga gtcgctttta tcggtctcca gaggtgctac tgggaatgcc ttatgacctt     1020

gccattgata tgtggtccct cgggtgtatt ttggttgaaa tgcacactgg agaacctctg     1080

ttcagtggtg ccaatgaggt agatcagatg aataaaatag tggaagttct gggtattcca     1140

cctgctcata ttcttgacca agcaccaaaa gcaagaaagt tctttgagaa gttgccagat     1200

ggcacttgga acttaaagaa gaccaaagat ggaaaacggg agtacaaacc accaggaacc     1260

cgtaaacttc ataacattct tggagtggaa acaggaggac ctggtgggcg acgtgctggg     1320

gagtcaggtc atacggtcgc tgactacttg aagttcaaag acctcatttt aaggatgctt     1380

gattatgacc ccaaaactcg aattcaacct tattatgctc tgcagcacag tttcttcaag     1440

aaaacagctg atgaaggtac aaatacaagt aatagtgtat ctacaagccc cgccatggag     1500

cagtctcagt cttcgggcac cacctccagt acatcgtcaa gctcaggtgc gtcagcaatt     1560

tcctgctcct cttggttggt caggcactga                                      1590


<210>  25
<211>  525
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK1A protein isoform 3

<400>  25

Met His Thr Gly Gly Glu Thr Ser Ala Cys Lys Pro Ser Ser Val Arg 
1               5                   10                  15      


Leu Ala Pro Ser Phe Ser Phe His Ala Ala Gly Leu Gln Met Ala Gly 
            20                  25                  30          


Gln Met Pro His Ser His Gln Tyr Ser Asp Arg Arg Gln Pro Asn Ile 
        35                  40                  45              


Ser Asp Gln Gln Val Ser Ala Leu Ser Tyr Ser Asp Gln Ile Gln Gln 
    50                  55                  60                  


Pro Leu Thr Asn Gln Val Met Pro Asp Ile Val Met Leu Gln Arg Arg 
65                  70                  75                  80  


Met Pro Gln Thr Phe Arg Asp Pro Ala Thr Ala Pro Leu Arg Lys Leu 
                85                  90                  95      


Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr 
            100                 105                 110         


Ala Lys Lys Lys Arg Arg His Gln Gln Gly Gln Gly Asp Asp Ser Ser 
        115                 120                 125             


His Lys Lys Glu Arg Lys Val Tyr Asn Asp Gly Tyr Asp Asp Asp Asn 
    130                 135                 140                 


Tyr Asp Tyr Ile Val Lys Asn Gly Glu Lys Trp Met Asp Arg Tyr Glu 
145                 150                 155                 160 


Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala 
                165                 170                 175     


Tyr Asp Arg Val Glu Gln Glu Trp Val Ala Ile Lys Ile Ile Lys Asn 
            180                 185                 190         


Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Val Arg Leu Leu Glu 
        195                 200                 205             


Leu Met Asn Lys His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu 
    210                 215                 220                 


Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Met 
225                 230                 235                 240 


Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr Asn Phe Arg Gly 
                245                 250                 255     


Val Ser Leu Asn Leu Thr Arg Lys Phe Ala Gln Gln Met Cys Thr Ala 
            260                 265                 270         


Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu 
        275                 280                 285             


Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys 
    290                 295                 300                 


Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln 
305                 310                 315                 320 


Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Met 
                325                 330                 335     


Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val 
            340                 345                 350         


Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ala Asn Glu Val Asp 
        355                 360                 365             


Gln Met Asn Lys Ile Val Glu Val Leu Gly Ile Pro Pro Ala His Ile 
    370                 375                 380                 


Leu Asp Gln Ala Pro Lys Ala Arg Lys Phe Phe Glu Lys Leu Pro Asp 
385                 390                 395                 400 


Gly Thr Trp Asn Leu Lys Lys Thr Lys Asp Gly Lys Arg Glu Tyr Lys 
                405                 410                 415     


Pro Pro Gly Thr Arg Lys Leu His Asn Ile Leu Gly Val Glu Thr Gly 
            420                 425                 430         


Gly Pro Gly Gly Arg Arg Ala Gly Glu Ser Gly His Thr Val Ala Asp 
        435                 440                 445             


Tyr Leu Lys Phe Lys Asp Leu Ile Leu Arg Met Leu Asp Tyr Asp Pro 
    450                 455                 460                 


Lys Thr Arg Ile Gln Pro Tyr Tyr Ala Leu Gln His Ser Phe Phe Lys 
465                 470                 475                 480 


Lys Thr Ala Asp Glu Gly Thr Asn Thr Ser Asn Ser Val Ser Thr Ser 
                485                 490                 495     


Pro Ala Met Glu Gln Ser Gln Ser Ser Gly Thr Thr Ser Ser Thr Ser 
            500                 505                 510         


Ser Ser Ser Gly Gly Ala Ala Leu Asp Ala Arg Cys Leu 
        515                 520                 525 


<210>  26
<211>  1578
<212>  DNA
<213>  Artificial

<220>
<223>  Human DYRK1A cDNA isoform 3

<400>  26
atgcatacag gaggagagac ttcagcatgc aaaccttcat ctgttcggct tgcaccgtca       60

ttttcattcc atgctgctgg ccttcagatg gctggacaga tgccccattc acatcagtac      120

agtgaccgtc gccagccaaa cataagtgac caacaggttt ctgccttatc atattctgac      180

cagattcagc aacctctaac taaccaggtg atgcctgata ttgtcatgtt acagaggcgg      240

atgccccaaa ccttccgtga cccagcaact gctcccctga gaaaactttc tgttgacttg      300

atcaaaacat acaagcatat taatgaggtt tactatgcaa aaaagaagcg aagacaccaa      360

cagggccagg gagacgattc tagtcataag aaggaacgga aggtttacaa tgatggttat      420

gatgatgata actatgatta tattgtaaaa aacggagaaa agtggatgga tcgttacgaa      480

attgactcct tgataggcaa aggttccttt ggacaggttg taaaggcata tgatcgtgtg      540

gagcaagaat gggttgccat taaaataata aagaacaaga aggcttttct gaatcaagca      600

cagatagaag tgcgacttct tgagctcatg aacaaacatg acactgaaat gaaatactac      660

atagtgcatt tgaaacgcca ctttatgttt cgaaaccatc tctgtttagt ttttgaaatg      720

ctgtcctaca acctctatga cttgctgaga aacaccaatt tccgaggggt ctctttgaac      780

ctaacacgaa agtttgcgca acagatgtgc actgcactgc ttttccttgc gactccagaa      840

cttagtatca ttcactgtga tctaaaacct gaaaatatcc ttctttgtaa ccccaaacgc      900

agtgcaatca agatagttga ctttggcagt tcttgtcagt tggggcagag gatataccag      960

tatattcaga gtcgctttta tcggtctcca gaggtgctac tgggaatgcc ttatgacctt     1020

gccattgata tgtggtccct cgggtgtatt ttggttgaaa tgcacactgg agaacctctg     1080

ttcagtggtg ccaatgaggt agatcagatg aataaaatag tggaagttct gggtattcca     1140

cctgctcata ttcttgacca agcaccaaaa gcaagaaagt tctttgagaa gttgccagat     1200

ggcacttgga acttaaagaa gaccaaagat ggaaaacggg agtacaaacc accaggaacc     1260

cgtaaacttc ataacattct tggagtggaa acaggaggac ctggtgggcg acgtgctggg     1320

gagtcaggtc atacggtcgc tgactacttg aagttcaaag acctcatttt aaggatgctt     1380

gattatgacc ccaaaactcg aattcaacct tattatgctc tgcagcacag tttcttcaag     1440

aaaacagctg atgaaggtac aaatacaagt aatagtgtat ctacaagccc cgccatggag     1500

cagtctcagt cttcgggcac cacctccagt acatcgtcaa gctcaggtgg agcagcactg     1560

gatgccaggt gcctttag                                                   1578


<210>  27
<211>  584
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK1A protein isoform 4

<400>  27

Met His Thr Gly Gly Glu Thr Ser Ala Cys Lys Pro Ser Ser Val Arg 
1               5                   10                  15      


Leu Ala Pro Ser Phe Ser Phe His Ala Ala Gly Leu Gln Met Ala Gly 
            20                  25                  30          


Gln Met Pro His Ser His Gln Tyr Ser Asp Arg Arg Gln Pro Asn Ile 
        35                  40                  45              


Ser Asp Gln Gln Val Ser Ala Leu Ser Tyr Ser Asp Gln Ile Gln Gln 
    50                  55                  60                  


Pro Leu Thr Asn Gln Val Met Pro Asp Ile Val Met Leu Gln Arg Arg 
65                  70                  75                  80  


Met Pro Gln Thr Phe Arg Asp Pro Ala Thr Ala Pro Leu Arg Lys Leu 
                85                  90                  95      


Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr 
            100                 105                 110         


Ala Lys Lys Lys Arg Arg His Gln Gln Gly Gln Gly Asp Asp Ser Ser 
        115                 120                 125             


His Lys Lys Glu Arg Lys Val Tyr Asn Asp Gly Tyr Asp Asp Asp Asn 
    130                 135                 140                 


Tyr Asp Tyr Ile Val Lys Asn Gly Glu Lys Trp Met Asp Arg Tyr Glu 
145                 150                 155                 160 


Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala 
                165                 170                 175     


Tyr Asp Arg Val Glu Gln Glu Trp Val Ala Ile Lys Ile Ile Lys Asn 
            180                 185                 190         


Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Val Arg Leu Leu Glu 
        195                 200                 205             


Leu Met Asn Lys His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu 
    210                 215                 220                 


Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Met 
225                 230                 235                 240 


Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr Asn Phe Arg Gly 
                245                 250                 255     


Val Ser Leu Asn Leu Thr Arg Lys Phe Ala Gln Gln Met Cys Thr Ala 
            260                 265                 270         


Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu 
        275                 280                 285             


Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys 
    290                 295                 300                 


Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln 
305                 310                 315                 320 


Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Met 
                325                 330                 335     


Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val 
            340                 345                 350         


Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ala Asn Glu Val Asp 
        355                 360                 365             


Gln Met Asn Lys Ile Val Glu Val Leu Gly Ile Pro Pro Ala His Ile 
    370                 375                 380                 


Leu Asp Gln Ala Pro Lys Ala Arg Lys Phe Phe Glu Lys Leu Pro Asp 
385                 390                 395                 400 


Gly Thr Trp Asn Leu Lys Lys Thr Lys Asp Gly Lys Arg Glu Tyr Lys 
                405                 410                 415     


Pro Pro Gly Thr Arg Lys Leu His Asn Ile Leu Gly Val Glu Thr Gly 
            420                 425                 430         


Gly Pro Gly Gly Arg Arg Ala Gly Glu Ser Gly His Thr Val Ala Asp 
        435                 440                 445             


Tyr Leu Lys Phe Lys Asp Leu Ile Leu Arg Met Leu Asp Tyr Asp Pro 
    450                 455                 460                 


Lys Thr Arg Ile Gln Pro Tyr Tyr Ala Leu Gln His Ser Phe Phe Lys 
465                 470                 475                 480 


Lys Thr Ala Asp Glu Gly Thr Asn Thr Ser Asn Ser Val Ser Thr Ser 
                485                 490                 495     


Pro Ala Met Glu Gln Ser Gln Ser Ser Gly Thr Thr Ser Ser Thr Ser 
            500                 505                 510         


Ser Ser Ser Gly Gly Ser Ser Gly Thr Ser Asn Ser Gly Arg Ala Arg 
        515                 520                 525             


Ser Asp Pro Thr His Gln His Arg His Ser Gly Gly His Phe Thr Ala 
    530                 535                 540                 


Ala Val Gln Ala Met Asp Cys Glu Thr His Ser Pro Gln Val Ser Ser 
545                 550                 555                 560 


His Val Val His Leu Leu Val Ser Pro Ala Ile Leu Arg Trp Ser Ser 
                565                 570                 575     


Thr Gly Cys Gln Val Pro Leu Glu 
            580                 


<210>  28
<211>  1755
<212>  DNA
<213>  Artificial

<220>
<223>  Human DYRK1A cDNA isoform 4

<400>  28
atgcatacag gaggagagac ttcagcatgc aaaccttcat ctgttcggct tgcaccgtca       60

ttttcattcc atgctgctgg ccttcagatg gctggacaga tgccccattc acatcagtac      120

agtgaccgtc gccagccaaa cataagtgac caacaggttt ctgccttatc atattctgac      180

cagattcagc aacctctaac taaccaggtg atgcctgata ttgtcatgtt acagaggcgg      240

atgccccaaa ccttccgtga cccagcaact gctcccctga gaaaactttc tgttgacttg      300

atcaaaacat acaagcatat taatgaggtt tactatgcaa aaaagaagcg aagacaccaa      360

cagggccagg gagacgattc tagtcataag aaggaacgga aggtttacaa tgatggttat      420

gatgatgata actatgatta tattgtaaaa aacggagaaa agtggatgga tcgttacgaa      480

attgactcct tgataggcaa aggttccttt ggacaggttg taaaggcata tgatcgtgtg      540

gagcaagaat gggttgccat taaaataata aagaacaaga aggcttttct gaatcaagca      600

cagatagaag tgcgacttct tgagctcatg aacaaacatg acactgaaat gaaatactac      660

atagtgcatt tgaaacgcca ctttatgttt cgaaaccatc tctgtttagt ttttgaaatg      720

ctgtcctaca acctctatga cttgctgaga aacaccaatt tccgaggggt ctctttgaac      780

ctaacacgaa agtttgcgca acagatgtgc actgcactgc ttttccttgc gactccagaa      840

cttagtatca ttcactgtga tctaaaacct gaaaatatcc ttctttgtaa ccccaaacgc      900

agtgcaatca agatagttga ctttggcagt tcttgtcagt tggggcagag gatataccag      960

tatattcaga gtcgctttta tcggtctcca gaggtgctac tgggaatgcc ttatgacctt     1020

gccattgata tgtggtccct cgggtgtatt ttggttgaaa tgcacactgg agaacctctg     1080

ttcagtggtg ccaatgaggt agatcagatg aataaaatag tggaagttct gggtattcca     1140

cctgctcata ttcttgacca agcaccaaaa gcaagaaagt tctttgagaa gttgccagat     1200

ggcacttgga acttaaagaa gaccaaagat ggaaaacggg agtacaaacc accaggaacc     1260

cgtaaacttc ataacattct tggagtggaa acaggaggac ctggtgggcg acgtgctggg     1320

gagtcaggtc atacggtcgc tgactacttg aagttcaaag acctcatttt aaggatgctt     1380

gattatgacc ccaaaactcg aattcaacct tattatgctc tgcagcacag tttcttcaag     1440

aaaacagctg atgaaggtac aaatacaagt aatagtgtat ctacaagccc cgccatggag     1500

cagtctcagt cttcgggcac cacctccagt acatcgtcaa gctcaggtgg ctcatcgggg     1560

acaagcaaca gtgggagagc ccggtcggat ccgacgcacc agcatcggca cagtggtggg     1620

cacttcacag ctgccgtgca ggccatggac tgcgagacac acagtcccca ggtgagctcg     1680

cacgtggttc atttgcttgt gtcacctgcc attctcaggt ggagcagcac tggatgccag     1740

gtgcctttag aatga                                                      1755


<210>  29
<211>  629
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK1B protein isoform 1

<400>  29

Met Ala Val Pro Pro Gly His Gly Pro Phe Ser Gly Phe Pro Gly Pro 
1               5                   10                  15      


Gln Glu His Thr Gln Val Leu Pro Asp Val Arg Leu Leu Pro Arg Arg 
            20                  25                  30          


Leu Pro Leu Ala Phe Arg Asp Ala Thr Ser Ala Pro Leu Arg Lys Leu 
        35                  40                  45              


Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr 
    50                  55                  60                  


Ala Lys Lys Lys Arg Arg Ala Gln Gln Ala Pro Pro Gln Asp Ser Ser 
65                  70                  75                  80  


Asn Lys Lys Glu Lys Lys Val Leu Asn His Gly Tyr Asp Asp Asp Asn 
                85                  90                  95      


His Asp Tyr Ile Val Arg Ser Gly Glu Arg Trp Leu Glu Arg Tyr Glu 
            100                 105                 110         


Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala 
        115                 120                 125             


Tyr Asp His Gln Thr Gln Glu Leu Val Ala Ile Lys Ile Ile Lys Asn 
    130                 135                 140                 


Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Leu Arg Leu Leu Glu 
145                 150                 155                 160 


Leu Met Asn Gln His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu 
                165                 170                 175     


Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Leu 
            180                 185                 190         


Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr His Phe Arg Gly 
        195                 200                 205             


Val Ser Leu Asn Leu Thr Arg Lys Leu Ala Gln Gln Leu Cys Thr Ala 
    210                 215                 220                 


Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu 
225                 230                 235                 240 


Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys 
                245                 250                 255     


Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln 
            260                 265                 270         


Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Thr 
        275                 280                 285             


Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val 
    290                 295                 300                 


Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ser Asn Glu Val Asp 
305                 310                 315                 320 


Gln Met Asn Arg Ile Val Glu Val Leu Gly Ile Pro Pro Ala Ala Met 
                325                 330                 335     


Leu Asp Gln Ala Pro Lys Ala Arg Lys Tyr Phe Glu Arg Leu Pro Gly 
            340                 345                 350         


Gly Gly Trp Thr Leu Arg Arg Thr Lys Glu Leu Arg Lys Asp Tyr Gln 
        355                 360                 365             


Gly Pro Gly Thr Arg Arg Leu Gln Glu Val Leu Gly Val Gln Thr Gly 
    370                 375                 380                 


Gly Pro Gly Gly Arg Arg Ala Gly Glu Pro Gly His Ser Pro Ala Asp 
385                 390                 395                 400 


Tyr Leu Arg Phe Gln Asp Leu Val Leu Arg Met Leu Glu Tyr Glu Pro 
                405                 410                 415     


Ala Ala Arg Ile Ser Pro Leu Gly Ala Leu Gln His Gly Phe Phe Arg 
            420                 425                 430         


Arg Thr Ala Asp Glu Ala Thr Asn Thr Gly Pro Ala Gly Ser Ser Ala 
        435                 440                 445             


Ser Thr Ser Pro Ala Pro Leu Asp Thr Cys Pro Ser Ser Ser Thr Ala 
    450                 455                 460                 


Ser Ser Ile Ser Ser Ser Gly Gly Ser Ser Gly Ser Ser Ser Asp Asn 
465                 470                 475                 480 


Arg Thr Tyr Arg Tyr Ser Asn Arg Tyr Cys Gly Gly Pro Gly Pro Pro 
                485                 490                 495     


Ile Thr Asp Cys Glu Met Asn Ser Pro Gln Val Pro Pro Ser Gln Pro 
            500                 505                 510         


Leu Arg Pro Trp Ala Gly Gly Asp Val Pro His Lys Thr His Gln Ala 
        515                 520                 525             


Pro Ala Ser Ala Ser Ser Leu Pro Gly Thr Gly Ala Gln Leu Pro Pro 
    530                 535                 540                 


Gln Pro Arg Tyr Leu Gly Arg Pro Pro Ser Pro Thr Ser Pro Pro Pro 
545                 550                 555                 560 


Pro Glu Leu Met Asp Val Ser Leu Val Gly Gly Pro Ala Asp Cys Ser 
                565                 570                 575     


Pro Pro His Pro Ala Pro Ala Pro Gln His Pro Ala Ala Ser Ala Leu 
            580                 585                 590         


Arg Thr Arg Met Thr Gly Gly Arg Pro Pro Leu Pro Pro Pro Asp Asp 
        595                 600                 605             


Pro Ala Thr Leu Gly Pro His Leu Gly Leu Arg Gly Val Pro Gln Ser 
    610                 615                 620                 


Thr Ala Ala Ser Ser 
625                 


<210>  30
<211>  1890
<212>  DNA
<213>  Artificial

<220>
<223>  Human DYRK1B cDNA isoform 1

<400>  30
atggccgtcc caccgggcca tggtcccttc tctggcttcc cagggcccca ggagcacacg       60

caggtattgc ctgatgtgcg gctactgcct cggaggctgc ccctggcctt ccgggatgca      120

acctcagccc cgctgcgtaa gctctctgtg gacctcatca agacctacaa gcacatcaat      180

gaggtatact atgcgaagaa gaagcggcgg gcccagcagg cgccacccca ggattcgagc      240

aacaagaagg agaagaaggt cctgaaccat ggttatgatg acgacaacca tgactacatc      300

gtgcgcagtg gcgagcgctg gctggagcgc tacgaaattg actcgctcat tggcaaaggc      360

tcctttggcc aggtggtgaa agcctatgat catcagaccc aggagcttgt ggccatcaag      420

atcatcaaga acaaaaaggc tttcctgaac caggcccaga ttgagctgcg gctgctggag      480

ctgatgaacc agcatgacac ggagatgaag tactatatag tacacctgaa gcggcacttc      540

atgttccgga accacctgtg cctggtattt gagctgctgt cctacaacct gtacgacctc      600

ctgcgcaaca cccacttccg cggcgtctcg ctgaacctga cccggaagct ggcgcagcag      660

ctctgcacgg cactgctctt tctggccacg cctgagctca gcatcattca ctgcgacctc      720

aagcccgaaa acatcttgct gtgcaacccc aagcgcagcg ccatcaagat tgtggacttc      780

ggcagctcct gccagcttgg ccagaggatc taccagtata tccagagccg cttctaccgc      840

tcacctgagg tgctcctggg cacaccctac gacctggcca ttgacatgtg gtccctgggc      900

tgcatccttg tggagatgca caccggagag cccctcttca gtggctccaa tgaggtcgac      960

cagatgaacc gcattgtgga ggtgctgggc atcccaccgg ccgccatgct ggaccaggcg     1020

cccaaggctc gcaagtactt tgaacggctg cctgggggtg gctggaccct acgaaggacg     1080

aaagaactca ggaaggatta ccagggcccc gggacacggc ggctgcagga ggtgctgggc     1140

gtgcagacgg gcgggcccgg gggccggcgg gcgggggagc cgggccacag ccccgccgac     1200

tacctccgct tccaggacct ggtgctgcgc atgctggagt atgagcccgc cgcccgcatc     1260

agccccctgg gggctctgca gcacggcttc ttccgccgca cggccgacga ggccaccaac     1320

acgggcccgg caggcagcag tgcctccacc tcgcccgcgc ccctcgacac ctgcccctct     1380

tccagcaccg ccagctccat ctccagttct ggaggctcca gtggctcctc cagtgacaac     1440

cggacctacc gctacagcaa ccgatattgt gggggccctg ggccccctat cacagactgt     1500

gagatgaaca gcccccaggt cccaccctcc cagccgctgc ggccctgggc agggggtgat     1560

gtgccccaca agacacatca agcccctgcc tctgcctcgt cactgcctgg gaccggggcc     1620

cagttacccc cccagccccg ataccttggt cgtcccccat caccaacctc accaccaccc     1680

ccggagctga tggatgtgag cctggtgggc ggccctgctg actgctcccc acctcaccca     1740

gcgcctgccc cccagcaccc ggctgcctca gccctccgga ctcggatgac tggaggtcgt     1800

ccacccctcc cgcctcctga tgaccctgcc actctggggc ctcacctggg cctccgtggt     1860

gtaccccaga gcacagcagc cagctcgtga                                      1890


<210>  31
<211>  589
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK1B protein isoform 2

<400>  31

Met Ala Val Pro Pro Gly His Gly Pro Phe Ser Gly Phe Pro Gly Pro 
1               5                   10                  15      


Gln Glu His Thr Gln Val Leu Pro Asp Val Arg Leu Leu Pro Arg Arg 
            20                  25                  30          


Leu Pro Leu Ala Phe Arg Asp Ala Thr Ser Ala Pro Leu Arg Lys Leu 
        35                  40                  45              


Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr 
    50                  55                  60                  


Ala Lys Lys Lys Arg Arg Ala Gln Gln Ala Pro Pro Gln Asp Ser Ser 
65                  70                  75                  80  


Asn Lys Lys Glu Lys Lys Val Leu Asn His Gly Tyr Asp Asp Asp Asn 
                85                  90                  95      


His Asp Tyr Ile Val Arg Ser Gly Glu Arg Trp Leu Glu Arg Tyr Glu 
            100                 105                 110         


Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala 
        115                 120                 125             


Tyr Asp His Gln Thr Gln Glu Leu Val Ala Ile Lys Ile Ile Lys Asn 
    130                 135                 140                 


Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Leu Arg Leu Leu Glu 
145                 150                 155                 160 


Leu Met Asn Gln His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu 
                165                 170                 175     


Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Leu 
            180                 185                 190         


Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr His Phe Arg Gly 
        195                 200                 205             


Val Ser Leu Asn Leu Thr Arg Lys Leu Ala Gln Gln Leu Cys Thr Ala 
    210                 215                 220                 


Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu 
225                 230                 235                 240 


Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys 
                245                 250                 255     


Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln 
            260                 265                 270         


Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Thr 
        275                 280                 285             


Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val 
    290                 295                 300                 


Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ser Asn Glu Val Asp 
305                 310                 315                 320 


Gln Met Asn Arg Ile Val Glu Val Leu Gly Ile Pro Pro Ala Ala Met 
                325                 330                 335     


Leu Asp Gln Ala Pro Lys Ala Arg Lys Tyr Phe Glu Arg Leu Pro Gly 
            340                 345                 350         


Gly Gly Trp Thr Leu Arg Arg Thr Lys Glu Leu Arg Lys Asp Leu Val 
        355                 360                 365             


Leu Arg Met Leu Glu Tyr Glu Pro Ala Ala Arg Ile Ser Pro Leu Gly 
    370                 375                 380                 


Ala Leu Gln His Gly Phe Phe Arg Arg Thr Ala Asp Glu Ala Thr Asn 
385                 390                 395                 400 


Thr Gly Pro Ala Gly Ser Ser Ala Ser Thr Ser Pro Ala Pro Leu Asp 
                405                 410                 415     


Thr Cys Pro Ser Ser Ser Thr Ala Ser Ser Ile Ser Ser Ser Gly Gly 
            420                 425                 430         


Ser Ser Gly Ser Ser Ser Asp Asn Arg Thr Tyr Arg Tyr Ser Asn Arg 
        435                 440                 445             


Tyr Cys Gly Gly Pro Gly Pro Pro Ile Thr Asp Cys Glu Met Asn Ser 
    450                 455                 460                 


Pro Gln Val Pro Pro Ser Gln Pro Leu Arg Pro Trp Ala Gly Gly Asp 
465                 470                 475                 480 


Val Pro His Lys Thr His Gln Ala Pro Ala Ser Ala Ser Ser Leu Pro 
                485                 490                 495     


Gly Thr Gly Ala Gln Leu Pro Pro Gln Pro Arg Tyr Leu Gly Arg Pro 
            500                 505                 510         


Pro Ser Pro Thr Ser Pro Pro Pro Pro Glu Leu Met Asp Val Ser Leu 
        515                 520                 525             


Val Gly Gly Pro Ala Asp Cys Ser Pro Pro His Pro Ala Pro Ala Pro 
    530                 535                 540                 


Gln His Pro Ala Ala Ser Ala Leu Arg Thr Arg Met Thr Gly Gly Arg 
545                 550                 555                 560 


Pro Pro Leu Pro Pro Pro Asp Asp Pro Ala Thr Leu Gly Pro His Leu 
                565                 570                 575     


Gly Leu Arg Gly Val Pro Gln Ser Thr Ala Ala Ser Ser 
            580                 585                 


<210>  32
<211>  1770
<212>  DNA
<213>  Artificial

<220>
<223>  Human DYRK1B cDNA isoform 2

<400>  32
atggccgtcc caccgggcca tggtcccttc tctggcttcc cagggcccca ggagcacacg       60

caggtattgc ctgatgtgcg gctactgcct cggaggctgc ccctggcctt ccgggatgca      120

acctcagccc cgctgcgtaa gctctctgtg gacctcatca agacctacaa gcacatcaat      180

gaggtatact atgcgaagaa gaagcggcgg gcccagcagg cgccacccca ggattcgagc      240

aacaagaagg agaagaaggt cctgaaccat ggttatgatg acgacaacca tgactacatc      300

gtgcgcagtg gcgagcgctg gctggagcgc tacgaaattg actcgctcat tggcaaaggc      360

tcctttggcc aggtggtgaa agcctatgat catcagaccc aggagcttgt ggccatcaag      420

atcatcaaga acaaaaaggc tttcctgaac caggcccaga ttgagctgcg gctgctggag      480

ctgatgaacc agcatgacac ggagatgaag tactatatag tacacctgaa gcggcacttc      540

atgttccgga accacctgtg cctggtattt gagctgctgt cctacaacct gtacgacctc      600

ctgcgcaaca cccacttccg cggcgtctcg ctgaacctga cccggaagct ggcgcagcag      660

ctctgcacgg cactgctctt tctggccacg cctgagctca gcatcattca ctgcgacctc      720

aagcccgaaa acatcttgct gtgcaacccc aagcgcagcg ccatcaagat tgtggacttc      780

ggcagctcct gccagcttgg ccagaggatc taccagtata tccagagccg cttctaccgc      840

tcacctgagg tgctcctggg cacaccctac gacctggcca ttgacatgtg gtccctgggc      900

tgcatccttg tggagatgca caccggagag cccctcttca gtggctccaa tgaggtcgac      960

cagatgaacc gcattgtgga ggtgctgggc atcccaccgg ccgccatgct ggaccaggcg     1020

cccaaggctc gcaagtactt tgaacggctg cctgggggtg gctggaccct acgaaggacg     1080

aaagaactca ggaaggacct ggtgctgcgc atgctggagt atgagcccgc cgcccgcatc     1140

agccccctgg gggctctgca gcacggcttc ttccgccgca cggccgacga ggccaccaac     1200

acgggcccgg caggcagcag tgcctccacc tcgcccgcgc ccctcgacac ctgcccctct     1260

tccagcaccg ccagctccat ctccagttct ggaggctcca gtggctcctc cagtgacaac     1320

cggacctacc gctacagcaa ccgatattgt gggggccctg ggccccctat cacagactgt     1380

gagatgaaca gcccccaggt cccaccctcc cagccgctgc ggccctgggc agggggtgat     1440

gtgccccaca agacacatca agcccctgcc tctgcctcgt cactgcctgg gaccggggcc     1500

cagttacccc cccagccccg ataccttggt cgtcccccat caccaacctc accaccaccc     1560

ccggagctga tggatgtgag cctggtgggc ggccctgctg actgctcccc acctcaccca     1620

gcgcctgccc cccagcaccc ggctgcctca gccctccgga ctcggatgac tggaggtcgt     1680

ccacccctcc cgcctcctga tgaccctgcc actctggggc ctcacctggg cctccgtggt     1740

gtaccccaga gcacagcagc cagctcgtga                                      1770


<210>  33
<211>  601
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK1B protein isoform 3

<400>  33

Met Ala Val Pro Pro Gly His Gly Pro Phe Ser Gly Phe Pro Gly Pro 
1               5                   10                  15      


Gln Glu His Thr Gln Val Leu Pro Asp Val Arg Leu Leu Pro Arg Arg 
            20                  25                  30          


Leu Pro Leu Ala Phe Arg Asp Ala Thr Ser Ala Pro Leu Arg Lys Leu 
        35                  40                  45              


Ser Val Asp Leu Ile Lys Thr Tyr Lys His Ile Asn Glu Val Tyr Tyr 
    50                  55                  60                  


Ala Lys Lys Lys Arg Arg Ala Gln Gln Ala Pro Pro Gln Asp Ser Ser 
65                  70                  75                  80  


Asn Lys Lys Glu Lys Lys Val Leu Asn His Gly Tyr Asp Asp Asp Asn 
                85                  90                  95      


His Asp Tyr Ile Val Arg Ser Gly Glu Arg Trp Leu Glu Arg Tyr Glu 
            100                 105                 110         


Ile Asp Ser Leu Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala 
        115                 120                 125             


Tyr Asp His Gln Thr Gln Glu Leu Val Ala Ile Lys Ile Ile Lys Asn 
    130                 135                 140                 


Lys Lys Ala Phe Leu Asn Gln Ala Gln Ile Glu Leu Arg Leu Leu Glu 
145                 150                 155                 160 


Leu Met Asn Gln His Asp Thr Glu Met Lys Tyr Tyr Ile Val His Leu 
                165                 170                 175     


Lys Arg His Phe Met Phe Arg Asn His Leu Cys Leu Val Phe Glu Leu 
            180                 185                 190         


Leu Ser Tyr Asn Leu Tyr Asp Leu Leu Arg Asn Thr His Phe Arg Gly 
        195                 200                 205             


Val Ser Leu Asn Leu Thr Arg Lys Leu Ala Gln Gln Leu Cys Thr Ala 
    210                 215                 220                 


Leu Leu Phe Leu Ala Thr Pro Glu Leu Ser Ile Ile His Cys Asp Leu 
225                 230                 235                 240 


Lys Pro Glu Asn Ile Leu Leu Cys Asn Pro Lys Arg Ser Ala Ile Lys 
                245                 250                 255     


Ile Val Asp Phe Gly Ser Ser Cys Gln Leu Gly Gln Arg Ile Tyr Gln 
            260                 265                 270         


Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Leu Leu Gly Thr 
        275                 280                 285             


Pro Tyr Asp Leu Ala Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Val 
    290                 295                 300                 


Glu Met His Thr Gly Glu Pro Leu Phe Ser Gly Ser Asn Glu Val Asp 
305                 310                 315                 320 


Gln Met Asn Arg Ile Val Glu Val Leu Gly Ile Pro Pro Ala Ala Met 
                325                 330                 335     


Leu Asp Gln Ala Pro Lys Ala Arg Lys Tyr Phe Glu Arg Leu Pro Gly 
            340                 345                 350         


Gly Gly Trp Thr Leu Arg Arg Thr Lys Glu Leu Arg Lys Asp Tyr Gln 
        355                 360                 365             


Gly Pro Gly Thr Arg Arg Leu Gln Glu Asp Leu Val Leu Arg Met Leu 
    370                 375                 380                 


Glu Tyr Glu Pro Ala Ala Arg Ile Ser Pro Leu Gly Ala Leu Gln His 
385                 390                 395                 400 


Gly Phe Phe Arg Arg Thr Ala Asp Glu Ala Thr Asn Thr Gly Pro Ala 
                405                 410                 415     


Gly Ser Ser Ala Ser Thr Ser Pro Ala Pro Leu Asp Thr Cys Pro Ser 
            420                 425                 430         


Ser Ser Thr Ala Ser Ser Ile Ser Ser Ser Gly Gly Ser Ser Gly Ser 
        435                 440                 445             


Ser Ser Asp Asn Arg Thr Tyr Arg Tyr Ser Asn Arg Tyr Cys Gly Gly 
    450                 455                 460                 


Pro Gly Pro Pro Ile Thr Asp Cys Glu Met Asn Ser Pro Gln Val Pro 
465                 470                 475                 480 


Pro Ser Gln Pro Leu Arg Pro Trp Ala Gly Gly Asp Val Pro His Lys 
                485                 490                 495     


Thr His Gln Ala Pro Ala Ser Ala Ser Ser Leu Pro Gly Thr Gly Ala 
            500                 505                 510         


Gln Leu Pro Pro Gln Pro Arg Tyr Leu Gly Arg Pro Pro Ser Pro Thr 
        515                 520                 525             


Ser Pro Pro Pro Pro Glu Leu Met Asp Val Ser Leu Val Gly Gly Pro 
    530                 535                 540                 


Ala Asp Cys Ser Pro Pro His Pro Ala Pro Ala Pro Gln His Pro Ala 
545                 550                 555                 560 


Ala Ser Ala Leu Arg Thr Arg Met Thr Gly Gly Arg Pro Pro Leu Pro 
                565                 570                 575     


Pro Pro Asp Asp Pro Ala Thr Leu Gly Pro His Leu Gly Leu Arg Gly 
            580                 585                 590         


Val Pro Gln Ser Thr Ala Ala Ser Ser 
        595                 600     


<210>  34
<211>  1806
<212>  DNA
<213>  Artificial

<220>
<223>  Human DYRK1B cDNA isoform 3

<400>  34
atggccgtcc caccgggcca tggtcccttc tctggcttcc cagggcccca ggagcacacg       60

caggtattgc ctgatgtgcg gctactgcct cggaggctgc ccctggcctt ccgggatgca      120

acctcagccc cgctgcgtaa gctctctgtg gacctcatca agacctacaa gcacatcaat      180

gaggtatact atgcgaagaa gaagcggcgg gcccagcagg cgccacccca ggattcgagc      240

aacaagaagg agaagaaggt cctgaaccat ggttatgatg acgacaacca tgactacatc      300

gtgcgcagtg gcgagcgctg gctggagcgc tacgaaattg actcgctcat tggcaaaggc      360

tcctttggcc aggtggtgaa agcctatgat catcagaccc aggagcttgt ggccatcaag      420

atcatcaaga acaaaaaggc tttcctgaac caggcccaga ttgagctgcg gctgctggag      480

ctgatgaacc agcatgacac ggagatgaag tactatatag tacacctgaa gcggcacttc      540

atgttccgga accacctgtg cctggtattt gagctgctgt cctacaacct gtacgacctc      600

ctgcgcaaca cccacttccg cggcgtctcg ctgaacctga cccggaagct ggcgcagcag      660

ctctgcacgg cactgctctt tctggccacg cctgagctca gcatcattca ctgcgacctc      720

aagcccgaaa acatcttgct gtgcaacccc aagcgcagcg ccatcaagat tgtggacttc      780

ggcagctcct gccagcttgg ccagaggatc taccagtata tccagagccg cttctaccgc      840

tcacctgagg tgctcctggg cacaccctac gacctggcca ttgacatgtg gtccctgggc      900

tgcatccttg tggagatgca caccggagag cccctcttca gtggctccaa tgaggtcgac      960

cagatgaacc gcattgtgga ggtgctgggc atcccaccgg ccgccatgct ggaccaggcg     1020

cccaaggctc gcaagtactt tgaacggctg cctgggggtg gctggaccct acgaaggacg     1080

aaagaactca ggaaggatta ccagggcccc gggacacggc ggctgcagga ggacctggtg     1140

ctgcgcatgc tggagtatga gcccgccgcc cgcatcagcc ccctgggggc tctgcagcac     1200

ggcttcttcc gccgcacggc cgacgaggcc accaacacgg gcccggcagg cagcagtgcc     1260

tccacctcgc ccgcgcccct cgacacctgc ccctcttcca gcaccgccag ctccatctcc     1320

agttctggag gctccagtgg ctcctccagt gacaaccgga cctaccgcta cagcaaccga     1380

tattgtgggg gccctgggcc ccctatcaca gactgtgaga tgaacagccc ccaggtccca     1440

ccctcccagc cgctgcggcc ctgggcaggg ggtgatgtgc cccacaagac acatcaagcc     1500

cctgcctctg cctcgtcact gcctgggacc ggggcccagt taccccccca gccccgatac     1560

cttggtcgtc ccccatcacc aacctcacca ccacccccgg agctgatgga tgtgagcctg     1620

gtgggcggcc ctgctgactg ctccccacct cacccagcgc ctgcccccca gcacccggct     1680

gcctcagccc tccggactcg gatgactgga ggtcgtccac ccctcccgcc tcctgatgac     1740

cctgccactc tggggcctca cctgggcctc cgtggtgtac cccagagcac agcagccagc     1800

tcgtga                                                                1806


<210>  35
<211>  601
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK2 protein isoform 1

<400>  35

Met Leu Thr Arg Lys Pro Ser Ala Ala Ala Pro Ala Ala Tyr Pro Thr 
1               5                   10                  15      


Gly Arg Gly Gly Asp Ser Ala Val Arg Gln Leu Gln Ala Ser Pro Gly 
            20                  25                  30          


Leu Gly Ala Gly Ala Thr Arg Ser Gly Val Gly Thr Gly Pro Pro Ser 
        35                  40                  45              


Pro Ile Ala Leu Pro Pro Leu Arg Ala Ser Asn Ala Ala Ala Ala Ala 
    50                  55                  60                  


His Thr Ile Gly Gly Ser Lys His Thr Met Asn Asp His Leu His Val 
65                  70                  75                  80  


Gly Ser His Ala His Gly Gln Ile Gln Val Gln Gln Leu Phe Glu Asp 
                85                  90                  95      


Asn Ser Asn Lys Arg Thr Val Leu Thr Thr Gln Pro Asn Gly Leu Thr 
            100                 105                 110         


Thr Val Gly Lys Thr Gly Leu Pro Val Val Pro Glu Arg Gln Leu Asp 
        115                 120                 125             


Ser Ile His Arg Arg Gln Gly Ser Ser Thr Ser Leu Lys Ser Met Glu 
    130                 135                 140                 


Gly Met Gly Lys Val Lys Ala Thr Pro Met Thr Pro Glu Gln Ala Met 
145                 150                 155                 160 


Lys Gln Tyr Met Gln Lys Leu Thr Ala Phe Glu His His Glu Ile Phe 
                165                 170                 175     


Ser Tyr Pro Glu Ile Tyr Phe Leu Gly Leu Asn Ala Lys Lys Arg Gln 
            180                 185                 190         


Gly Met Thr Gly Gly Pro Asn Asn Gly Gly Tyr Asp Asp Asp Gln Gly 
        195                 200                 205             


Ser Tyr Val Gln Val Pro His Asp His Val Ala Tyr Arg Tyr Glu Val 
    210                 215                 220                 


Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala Tyr 
225                 230                 235                 240 


Asp His Lys Val His Gln His Val Ala Leu Lys Met Val Arg Asn Glu 
                245                 250                 255     


Lys Arg Phe His Arg Gln Ala Ala Glu Glu Ile Arg Ile Leu Glu His 
            260                 265                 270         


Leu Arg Lys Gln Asp Lys Asp Asn Thr Met Asn Val Ile His Met Leu 
        275                 280                 285             


Glu Asn Phe Thr Phe Arg Asn His Ile Cys Met Thr Phe Glu Leu Leu 
    290                 295                 300                 


Ser Met Asn Leu Tyr Glu Leu Ile Lys Lys Asn Lys Phe Gln Gly Phe 
305                 310                 315                 320 


Ser Leu Pro Leu Val Arg Lys Phe Ala His Ser Ile Leu Gln Cys Leu 
                325                 330                 335     


Asp Ala Leu His Lys Asn Arg Ile Ile His Cys Asp Leu Lys Pro Glu 
            340                 345                 350         


Asn Ile Leu Leu Lys Gln Gln Gly Arg Ser Gly Ile Lys Val Ile Asp 
        355                 360                 365             


Phe Gly Ser Ser Cys Tyr Glu His Gln Arg Val Tyr Thr Tyr Ile Gln 
    370                 375                 380                 


Ser Arg Phe Tyr Arg Ala Pro Glu Val Ile Leu Gly Ala Arg Tyr Gly 
385                 390                 395                 400 


Met Pro Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Ala Glu Leu Leu 
                405                 410                 415     


Thr Gly Tyr Pro Leu Leu Pro Gly Glu Asp Glu Gly Asp Gln Leu Ala 
            420                 425                 430         


Cys Met Ile Glu Leu Leu Gly Met Pro Ser Gln Lys Leu Leu Asp Ala 
        435                 440                 445             


Ser Lys Arg Ala Lys Asn Phe Val Ser Ser Lys Gly Tyr Pro Arg Tyr 
    450                 455                 460                 


Cys Thr Val Thr Thr Leu Ser Asp Gly Ser Val Val Leu Asn Gly Gly 
465                 470                 475                 480 


Arg Ser Arg Arg Gly Lys Leu Arg Gly Pro Pro Glu Ser Arg Glu Trp 
                485                 490                 495     


Gly Asn Ala Leu Lys Gly Cys Asp Asp Pro Leu Phe Leu Asp Phe Leu 
            500                 505                 510         


Lys Gln Cys Leu Glu Trp Asp Pro Ala Val Arg Met Thr Pro Gly Gln 
        515                 520                 525             


Ala Leu Arg His Pro Trp Leu Arg Arg Arg Leu Pro Lys Pro Pro Thr 
    530                 535                 540                 


Gly Glu Lys Thr Ser Val Lys Arg Ile Thr Glu Ser Thr Gly Ala Ile 
545                 550                 555                 560 


Thr Ser Ile Ser Lys Leu Pro Pro Pro Ser Ser Ser Ala Ser Lys Leu 
                565                 570                 575     


Arg Thr Asn Leu Ala Gln Met Thr Asp Ala Asn Gly Asn Ile Gln Gln 
            580                 585                 590         


Arg Thr Val Leu Pro Lys Leu Val Ser 
        595                 600     


<210>  36
<211>  1806
<212>  DNA
<213>  Artificial

<220>
<223>  Human DYRK2 cDNA isoform

<400>  36
atgttaacca ggaaaccttc ggccgccgct cccgccgcct acccgaccgg ccgaggtggg       60

gacagcgccg ttcgtcagct tcaggcttcc ccggggctcg gtgcaggggc cacccggagc      120

ggagtgggga ctggcccgcc ctcccccatc gccctgccgc ctctccgggc cagcaacgct      180

gccgccgcag cccacacgat tggcggcagt aagcacacaa tgaatgatca cctgcatgtc      240

ggcagccacg ctcacggaca gatccaggtt caacagttgt ttgaggataa cagtaacaag      300

cggacagtgc tcacgacaca accaaatggg cttacaacag tgggcaaaac gggcttgcca      360

gtggtgccag agcggcagct ggacagcatt catagacggc aggggagctc cacctctcta      420

aagtccatgg aaggcatggg gaaggtgaaa gccaccccca tgacacctga acaagcaatg      480

aagcaataca tgcaaaaact cacagccttc gaacaccatg agattttcag ctaccctgaa      540

atatatttct tgggtctaaa tgctaagaag cgccagggca tgacaggtgg gcccaacaat      600

ggtggctatg atgatgacca gggatcatat gtgcaggtgc cccacgatca cgtggcttac      660

aggtatgagg tcctcaaggt cattgggaag gggagctttg ggcaggtggt caaggcctac      720

gatcacaaag tccaccagca cgtggcccta aagatggtgc ggaatgagaa gcgcttccac      780

cggcaagcag cggaggagat ccgaatcctg gaacacctgc ggaagcagga caaggataac      840

acaatgaatg tcatccatat gctggagaat ttcaccttcc gcaaccacat ctgcatgacg      900

tttgagctgc tgagcatgaa cctctatgag ctcatcaaga agaataaatt ccagggcttc      960

agtctgcctt tggttcgcaa gtttgcccac tcgattctgc agtgcttgga tgctttgcac     1020

aaaaacagaa taattcactg tgaccttaag cccgagaaca ttttgttaaa gcagcagggt     1080

agaagcggta ttaaagtaat tgattttggc tccagttgtt acgagcatca gcgtgtctac     1140

acgtacatcc agtcgcgttt ttaccgggct ccagaagtga tccttggggc caggtatggc     1200

atgcccattg atatgtggag cctgggctgc attttagcag agctcctgac gggttacccc     1260

ctcttgcctg gggaagatga aggggaccag ctggcctgta tgattgaact gttgggcatg     1320

ccctcacaga aactgctgga tgcatccaaa cgagccaaaa attttgtgag ctccaagggt     1380

tatccccgtt actgcactgt cacgactctc tcagatggct ctgtggtcct aaacggaggc     1440

cgttcccgga gggggaaact gaggggccca ccggagagca gagagtgggg gaacgcgctg     1500

aaggggtgtg atgatcccct tttccttgac ttcttaaaac agtgtttaga gtgggatcct     1560

gcagtgcgca tgaccccagg ccaggctttg cggcacccct ggctgaggag gcggttgcca     1620

aagcctccca ccggggagaa aacgtcagtg aaaaggataa ctgagagcac cggtgctatc     1680

acatctatat ccaagttacc tccaccttct agctcagctt ccaaactgag gactaatttg     1740

gcgcagatga cagatgccaa tgggaatatt cagcagagga cagtgttgcc aaaacttgtt     1800

agctga                                                                1806


<210>  37
<211>  528
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK2 protein isoform 2

<400>  37

Met Asn Asp His Leu His Val Gly Ser His Ala His Gly Gln Ile Gln 
1               5                   10                  15      


Val Gln Gln Leu Phe Glu Asp Asn Ser Asn Lys Arg Thr Val Leu Thr 
            20                  25                  30          


Thr Gln Pro Asn Gly Leu Thr Thr Val Gly Lys Thr Gly Leu Pro Val 
        35                  40                  45              


Val Pro Glu Arg Gln Leu Asp Ser Ile His Arg Arg Gln Gly Ser Ser 
    50                  55                  60                  


Thr Ser Leu Lys Ser Met Glu Gly Met Gly Lys Val Lys Ala Thr Pro 
65                  70                  75                  80  


Met Thr Pro Glu Gln Ala Met Lys Gln Tyr Met Gln Lys Leu Thr Ala 
                85                  90                  95      


Phe Glu His His Glu Ile Phe Ser Tyr Pro Glu Ile Tyr Phe Leu Gly 
            100                 105                 110         


Leu Asn Ala Lys Lys Arg Gln Gly Met Thr Gly Gly Pro Asn Asn Gly 
        115                 120                 125             


Gly Tyr Asp Asp Asp Gln Gly Ser Tyr Val Gln Val Pro His Asp His 
    130                 135                 140                 


Val Ala Tyr Arg Tyr Glu Val Leu Lys Val Ile Gly Lys Gly Ser Phe 
145                 150                 155                 160 


Gly Gln Val Val Lys Ala Tyr Asp His Lys Val His Gln His Val Ala 
                165                 170                 175     


Leu Lys Met Val Arg Asn Glu Lys Arg Phe His Arg Gln Ala Ala Glu 
            180                 185                 190         


Glu Ile Arg Ile Leu Glu His Leu Arg Lys Gln Asp Lys Asp Asn Thr 
        195                 200                 205             


Met Asn Val Ile His Met Leu Glu Asn Phe Thr Phe Arg Asn His Ile 
    210                 215                 220                 


Cys Met Thr Phe Glu Leu Leu Ser Met Asn Leu Tyr Glu Leu Ile Lys 
225                 230                 235                 240 


Lys Asn Lys Phe Gln Gly Phe Ser Leu Pro Leu Val Arg Lys Phe Ala 
                245                 250                 255     


His Ser Ile Leu Gln Cys Leu Asp Ala Leu His Lys Asn Arg Ile Ile 
            260                 265                 270         


His Cys Asp Leu Lys Pro Glu Asn Ile Leu Leu Lys Gln Gln Gly Arg 
        275                 280                 285             


Ser Gly Ile Lys Val Ile Asp Phe Gly Ser Ser Cys Tyr Glu His Gln 
    290                 295                 300                 


Arg Val Tyr Thr Tyr Ile Gln Ser Arg Phe Tyr Arg Ala Pro Glu Val 
305                 310                 315                 320 


Ile Leu Gly Ala Arg Tyr Gly Met Pro Ile Asp Met Trp Ser Leu Gly 
                325                 330                 335     


Cys Ile Leu Ala Glu Leu Leu Thr Gly Tyr Pro Leu Leu Pro Gly Glu 
            340                 345                 350         


Asp Glu Gly Asp Gln Leu Ala Cys Met Ile Glu Leu Leu Gly Met Pro 
        355                 360                 365             


Ser Gln Lys Leu Leu Asp Ala Ser Lys Arg Ala Lys Asn Phe Val Ser 
    370                 375                 380                 


Ser Lys Gly Tyr Pro Arg Tyr Cys Thr Val Thr Thr Leu Ser Asp Gly 
385                 390                 395                 400 


Ser Val Val Leu Asn Gly Gly Arg Ser Arg Arg Gly Lys Leu Arg Gly 
                405                 410                 415     


Pro Pro Glu Ser Arg Glu Trp Gly Asn Ala Leu Lys Gly Cys Asp Asp 
            420                 425                 430         


Pro Leu Phe Leu Asp Phe Leu Lys Gln Cys Leu Glu Trp Asp Pro Ala 
        435                 440                 445             


Val Arg Met Thr Pro Gly Gln Ala Leu Arg His Pro Trp Leu Arg Arg 
    450                 455                 460                 


Arg Leu Pro Lys Pro Pro Thr Gly Glu Lys Thr Ser Val Lys Arg Ile 
465                 470                 475                 480 


Thr Glu Ser Thr Gly Ala Ile Thr Ser Ile Ser Lys Leu Pro Pro Pro 
                485                 490                 495     


Ser Ser Ser Ala Ser Lys Leu Arg Thr Asn Leu Ala Gln Met Thr Asp 
            500                 505                 510         


Ala Asn Gly Asn Ile Gln Gln Arg Thr Val Leu Pro Lys Leu Val Ser 
        515                 520                 525             


<210>  38
<211>  1586
<212>  DNA
<213>  Artificial

<220>
<223>  Human DYRK2 cDNA isoform 2

<400>  38
atgaatgatc acctgcatgt cggcagccac gctcacggac agatccaggt tcaacagttg       60

tttgaggata acagtaacaa gcggacagtg ctcacgacac aaccaaatgg gcttacaaca      120

gtgggcaaaa cgggcttgcc agtggtgcca gagcggcagc tggacagcat tcatagacgg      180

caggggagct ccacctctct aaagtccatg gaaggcatgg ggaaggtgaa agccaccccc      240

atgacacctg aacaagcaat gaagcaatac atgcaaaaac tcacagcctt cgaacaccat      300

gagattttca gctaccctga aatatatttc ttgggtctaa atgctaagaa gcgccagggc      360

atgacaggtg ggcccaacaa tggtggctat gatgatgacc agggatcata tgtgcaggtg      420

ccccacgatc acgtggctta caggtatgag gtcctcaagg tcattgggaa ggggagcttt      480

gggcaggtgg tcaaggccta cgatcacaaa gtccaccagc acgtggccct aaagatggtg      540

cggaatgaga agcgcttcca ccggcaagca gcggaggaga tccgaatcct ggaacacctg      600

cggaagcagg acaaggataa cacaatgaat gtcatccata tgctggagat ttcaccttcc      660

gcaaccacat ctgcatgacg tttgagctgc tgagcatgaa cctctatgag ctcatcaaga      720

agaataaatt ccagggcttc agtctgcctt tggttcgcaa gtttgcccac tcgattctgc      780

agtgcttgga tgctttgcac aaaaacagaa taattcactg tgaccttaag cccgagaaca      840

ttttgttaaa gcagcagggt agaagcggta ttaaagtaat tgattttggc tccagttgtt      900

acgagcatca gcgtgtctac acgtacatcc agtcgcgttt ttaccgggct ccagaagtga      960

tccttggggc caggtatggc atgcccattg atatgtggag cctgggctgc attttagcag     1020

agctcctgac gggttacccc ctcttgcctg gggaagatga aggggaccag ctggcctgta     1080

tgattgaact gttgggcatg ccctcacaga aactgctgga tgcatccaaa cgagccaaaa     1140

attttgtgag ctccaagggt tatccccgtt actgcactgt cacgactctc tcagatggct     1200

ctgtggtcct aaacggaggc cgttcccgga gggggaaact gaggggccca ccggagagca     1260

gagagtgggg gaacgcgctg aaggggtgtg atgatcccct tttccttgac ttcttaaaac     1320

agtgtttaga gtgggatcct gcagtgcgca tgaccccagg ccaggctttg cggcacccct     1380

ggctgaggag gcggttgcca aagcctccca ccggggagaa aacgtcagtg aaaaggataa     1440

ctgagagcac cggtgctatc acatctatat ccaagttacc tccaccttct agctcagctt     1500

ccaaactgag gactaatttg gcgcagatga cagatgccaa tgggaatatt cagcagagga     1560

cagtgttgcc aaaacttgtt agctga                                          1586


<210>  39
<211>  588
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK3 protein isoform 1

<400>  39

Met Gly Gly Thr Ala Arg Gly Pro Gly Arg Lys Asp Ala Gly Pro Pro 
1               5                   10                  15      


Gly Ala Gly Leu Pro Pro Gln Gln Arg Arg Leu Gly Asp Gly Val Tyr 
            20                  25                  30          


Asp Thr Phe Met Met Ile Asp Glu Thr Lys Cys Pro Pro Cys Ser Asn 
        35                  40                  45              


Val Leu Cys Asn Pro Ser Glu Pro Pro Pro Pro Arg Arg Leu Asn Met 
    50                  55                  60                  


Thr Thr Glu Gln Phe Thr Gly Asp His Thr Gln His Phe Leu Asp Gly 
65                  70                  75                  80  


Gly Glu Met Lys Val Glu Gln Leu Phe Gln Glu Phe Gly Asn Arg Lys 
                85                  90                  95      


Ser Asn Thr Ile Gln Ser Asp Gly Ile Ser Asp Ser Glu Lys Cys Ser 
            100                 105                 110         


Pro Thr Val Ser Gln Gly Lys Ser Ser Asp Cys Leu Asn Thr Val Lys 
        115                 120                 125             


Ser Asn Ser Ser Ser Lys Ala Pro Lys Val Val Pro Leu Thr Pro Glu 
    130                 135                 140                 


Gln Ala Leu Lys Gln Tyr Lys His His Leu Thr Ala Tyr Glu Lys Leu 
145                 150                 155                 160 


Glu Ile Ile Asn Tyr Pro Glu Ile Tyr Phe Val Gly Pro Asn Ala Lys 
                165                 170                 175     


Lys Arg His Gly Val Ile Gly Gly Pro Asn Asn Gly Gly Tyr Asp Asp 
            180                 185                 190         


Ala Asp Gly Ala Tyr Ile His Val Pro Arg Asp His Leu Ala Tyr Arg 
        195                 200                 205             


Tyr Glu Val Leu Lys Ile Ile Gly Lys Gly Ser Phe Gly Gln Val Ala 
    210                 215                 220                 


Arg Val Tyr Asp His Lys Leu Arg Gln Tyr Val Ala Leu Lys Met Val 
225                 230                 235                 240 


Arg Asn Glu Lys Arg Phe His Arg Gln Ala Ala Glu Glu Ile Arg Ile 
                245                 250                 255     


Leu Glu His Leu Lys Lys Gln Asp Lys Thr Gly Ser Met Asn Val Ile 
            260                 265                 270         


His Met Leu Glu Ser Phe Thr Phe Arg Asn His Val Cys Met Ala Phe 
        275                 280                 285             


Glu Leu Leu Ser Ile Asp Leu Tyr Glu Leu Ile Lys Lys Asn Lys Phe 
    290                 295                 300                 


Gln Gly Phe Ser Val Gln Leu Val Arg Lys Phe Ala Gln Ser Ile Leu 
305                 310                 315                 320 


Gln Ser Leu Asp Ala Leu His Lys Asn Lys Ile Ile His Cys Asp Leu 
                325                 330                 335     


Lys Pro Glu Asn Ile Leu Leu Lys His His Gly Arg Ser Ser Thr Lys 
            340                 345                 350         


Val Ile Asp Phe Gly Ser Ser Cys Phe Glu Tyr Gln Lys Leu Tyr Thr 
        355                 360                 365             


Tyr Ile Gln Ser Arg Phe Tyr Arg Ala Pro Glu Ile Ile Leu Gly Ser 
    370                 375                 380                 


Arg Tyr Ser Thr Pro Ile Asp Ile Trp Ser Phe Gly Cys Ile Leu Ala 
385                 390                 395                 400 


Glu Leu Leu Thr Gly Gln Pro Leu Phe Pro Gly Glu Asp Glu Gly Asp 
                405                 410                 415     


Gln Leu Ala Cys Met Met Glu Leu Leu Gly Met Pro Pro Pro Lys Leu 
            420                 425                 430         


Leu Glu Gln Ser Lys Arg Ala Lys Tyr Phe Ile Asn Ser Lys Gly Ile 
        435                 440                 445             


Pro Arg Tyr Cys Ser Val Thr Thr Gln Ala Asp Gly Arg Val Val Leu 
    450                 455                 460                 


Val Gly Gly Arg Ser Arg Arg Gly Lys Lys Arg Gly Pro Pro Gly Ser 
465                 470                 475                 480 


Lys Asp Trp Gly Thr Ala Leu Lys Gly Cys Asp Asp Tyr Leu Phe Ile 
                485                 490                 495     


Glu Phe Leu Lys Arg Cys Leu His Trp Asp Pro Ser Ala Arg Leu Thr 
            500                 505                 510         


Pro Ala Gln Ala Leu Arg His Pro Trp Ile Ser Lys Ser Val Pro Arg 
        515                 520                 525             


Pro Leu Thr Thr Ile Asp Lys Val Ser Gly Lys Arg Val Val Asn Pro 
    530                 535                 540                 


Ala Ser Ala Phe Gln Gly Leu Gly Ser Lys Leu Pro Pro Val Val Gly 
545                 550                 555                 560 


Ile Ala Asn Lys Leu Lys Ala Asn Leu Met Ser Glu Thr Asn Gly Ser 
                565                 570                 575     


Ile Pro Leu Cys Ser Val Leu Pro Lys Leu Ile Ser 
            580                 585             


<210>  40
<211>  1767
<212>  DNA
<213>  Artificial

<220>
<223>  Human DYRK3 cDNA isoform 1

<400>  40
atgggaggca cagctcgtgg gcctgggcgg aaggatgcgg ggccgcctgg ggccgggctc       60

ccgccccagc agcggaggtt gggggatggt gtctatgaca ccttcatgat gatagatgaa      120

accaaatgtc ccccctgttc aaatgtactc tgcaatcctt ctgaaccacc tccacccaga      180

agactaaata tgaccactga gcagtttaca ggagatcata ctcagcactt tttggatgga      240

ggtgagatga aggtagaaca gctgtttcaa gaatttggca acagaaaatc caatactatt      300

cagtcagatg gcatcagtga ctctgaaaaa tgctctccta ctgtttctca gggtaaaagt      360

tcagattgct tgaatacagt aaaatccaac agttcatcca aggcacccaa agtggtgcct      420

ctgactccag aacaagccct gaagcaatat aaacaccacc tcactgccta tgagaaactg      480

gaaataatta attatccaga aatttacttt gtaggtccaa atgccaagaa aagacatgga      540

gttattggtg gtcccaataa tggagggtat gatgatgcag atggggccta tattcatgta      600

cctcgagacc atctagctta tcgatatgag gtgctgaaaa ttattggcaa ggggagtttt      660

gggcaggtgg ccagggtcta tgatcacaaa cttcgacagt acgtggccct aaaaatggtg      720

cgcaatgaga agcgctttca tcgtcaagca gctgaggaga tccggatttt ggagcatctt      780

aagaaacagg ataaaactgg tagtatgaac gttatccaca tgctggaaag tttcacattc      840

cggaaccatg tttgcatggc ctttgaattg ctgagcatag acctttatga gctgattaaa      900

aaaaataagt ttcagggttt tagcgtccag ttggtacgca agtttgccca gtccatcttg      960

caatctttgg atgccctcca caaaaataag attattcact gcgatctgaa gccagaaaac     1020

attctcctga aacaccacgg gcgcagttca accaaggtca ttgactttgg gtccagctgt     1080

ttcgagtacc agaagctcta cacatatatc cagtctcggt tctacagagc tccagaaatc     1140

atcttaggaa gccgctacag cacaccaatt gacatatgga gttttggctg catccttgca     1200

gaacttttaa caggacagcc tctcttccct ggagaggatg aaggagacca gttggcctgc     1260

atgatggagc ttctagggat gccaccacca aaacttctgg agcaatccaa acgtgccaag     1320

tactttatta attccaaggg cataccccgc tactgctctg tgactaccca ggcagatggg     1380

agggttgtgc ttgtgggggg tcgctcacgt aggggtaaaa agcggggtcc cccaggcagc     1440

aaagactggg ggacagcact gaaagggtgt gatgactact tgtttataga gttcttgaaa     1500

aggtgtcttc actgggaccc ctctgcccgc ttgaccccag ctcaagcatt aagacaccct     1560

tggattagca agtctgtccc cagacctctc accaccatag acaaggtgtc agggaaacgg     1620

gtagttaatc ctgcaagtgc tttccaggga ttgggttcta agctgcctcc agttgttgga     1680

atagccaata agcttaaagc taacttaatg tcagaaacca atggtagtat acccctatgc     1740

agtgtattgc caaaactgat tagctag                                         1767


<210>  41
<211>  568
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK3 protein isoform 2

<400>  41

Met Lys Trp Lys Glu Lys Leu Gly Asp Gly Val Tyr Asp Thr Phe Met 
1               5                   10                  15      


Met Ile Asp Glu Thr Lys Cys Pro Pro Cys Ser Asn Val Leu Cys Asn 
            20                  25                  30          


Pro Ser Glu Pro Pro Pro Pro Arg Arg Leu Asn Met Thr Thr Glu Gln 
        35                  40                  45              


Phe Thr Gly Asp His Thr Gln His Phe Leu Asp Gly Gly Glu Met Lys 
    50                  55                  60                  


Val Glu Gln Leu Phe Gln Glu Phe Gly Asn Arg Lys Ser Asn Thr Ile 
65                  70                  75                  80  


Gln Ser Asp Gly Ile Ser Asp Ser Glu Lys Cys Ser Pro Thr Val Ser 
                85                  90                  95      


Gln Gly Lys Ser Ser Asp Cys Leu Asn Thr Val Lys Ser Asn Ser Ser 
            100                 105                 110         


Ser Lys Ala Pro Lys Val Val Pro Leu Thr Pro Glu Gln Ala Leu Lys 
        115                 120                 125             


Gln Tyr Lys His His Leu Thr Ala Tyr Glu Lys Leu Glu Ile Ile Asn 
    130                 135                 140                 


Tyr Pro Glu Ile Tyr Phe Val Gly Pro Asn Ala Lys Lys Arg His Gly 
145                 150                 155                 160 


Val Ile Gly Gly Pro Asn Asn Gly Gly Tyr Asp Asp Ala Asp Gly Ala 
                165                 170                 175     


Tyr Ile His Val Pro Arg Asp His Leu Ala Tyr Arg Tyr Glu Val Leu 
            180                 185                 190         


Lys Ile Ile Gly Lys Gly Ser Phe Gly Gln Val Ala Arg Val Tyr Asp 
        195                 200                 205             


His Lys Leu Arg Gln Tyr Val Ala Leu Lys Met Val Arg Asn Glu Lys 
    210                 215                 220                 


Arg Phe His Arg Gln Ala Ala Glu Glu Ile Arg Ile Leu Glu His Leu 
225                 230                 235                 240 


Lys Lys Gln Asp Lys Thr Gly Ser Met Asn Val Ile His Met Leu Glu 
                245                 250                 255     


Ser Phe Thr Phe Arg Asn His Val Cys Met Ala Phe Glu Leu Leu Ser 
            260                 265                 270         


Ile Asp Leu Tyr Glu Leu Ile Lys Lys Asn Lys Phe Gln Gly Phe Ser 
        275                 280                 285             


Val Gln Leu Val Arg Lys Phe Ala Gln Ser Ile Leu Gln Ser Leu Asp 
    290                 295                 300                 


Ala Leu His Lys Asn Lys Ile Ile His Cys Asp Leu Lys Pro Glu Asn 
305                 310                 315                 320 


Ile Leu Leu Lys His His Gly Arg Ser Ser Thr Lys Val Ile Asp Phe 
                325                 330                 335     


Gly Ser Ser Cys Phe Glu Tyr Gln Lys Leu Tyr Thr Tyr Ile Gln Ser 
            340                 345                 350         


Arg Phe Tyr Arg Ala Pro Glu Ile Ile Leu Gly Ser Arg Tyr Ser Thr 
        355                 360                 365             


Pro Ile Asp Ile Trp Ser Phe Gly Cys Ile Leu Ala Glu Leu Leu Thr 
    370                 375                 380                 


Gly Gln Pro Leu Phe Pro Gly Glu Asp Glu Gly Asp Gln Leu Ala Cys 
385                 390                 395                 400 


Met Met Glu Leu Leu Gly Met Pro Pro Pro Lys Leu Leu Glu Gln Ser 
                405                 410                 415     


Lys Arg Ala Lys Tyr Phe Ile Asn Ser Lys Gly Ile Pro Arg Tyr Cys 
            420                 425                 430         


Ser Val Thr Thr Gln Ala Asp Gly Arg Val Val Leu Val Gly Gly Arg 
        435                 440                 445             


Ser Arg Arg Gly Lys Lys Arg Gly Pro Pro Gly Ser Lys Asp Trp Gly 
    450                 455                 460                 


Thr Ala Leu Lys Gly Cys Asp Asp Tyr Leu Phe Ile Glu Phe Leu Lys 
465                 470                 475                 480 


Arg Cys Leu His Trp Asp Pro Ser Ala Arg Leu Thr Pro Ala Gln Ala 
                485                 490                 495     


Leu Arg His Pro Trp Ile Ser Lys Ser Val Pro Arg Pro Leu Thr Thr 
            500                 505                 510         


Ile Asp Lys Val Ser Gly Lys Arg Val Val Asn Pro Ala Ser Ala Phe 
        515                 520                 525             


Gln Gly Leu Gly Ser Lys Leu Pro Pro Val Val Gly Ile Ala Asn Lys 
    530                 535                 540                 


Leu Lys Ala Asn Leu Met Ser Glu Thr Asn Gly Ser Ile Pro Leu Cys 
545                 550                 555                 560 


Ser Val Leu Pro Lys Leu Ile Ser 
                565             


<210>  42
<211>  1707
<212>  DNA
<213>  Artificial

<220>
<223>  Human DYRK3 cDNA isoform 2

<400>  42
atgaagtgga aagagaagtt gggggatggt gtctatgaca ccttcatgat gatagatgaa       60

accaaatgtc ccccctgttc aaatgtactc tgcaatcctt ctgaaccacc tccacccaga      120

agactaaata tgaccactga gcagtttaca ggagatcata ctcagcactt tttggatgga      180

ggtgagatga aggtagaaca gctgtttcaa gaatttggca acagaaaatc caatactatt      240

cagtcagatg gcatcagtga ctctgaaaaa tgctctccta ctgtttctca gggtaaaagt      300

tcagattgct tgaatacagt aaaatccaac agttcatcca aggcacccaa agtggtgcct      360

ctgactccag aacaagccct gaagcaatat aaacaccacc tcactgccta tgagaaactg      420

gaaataatta attatccaga aatttacttt gtaggtccaa atgccaagaa aagacatgga      480

gttattggtg gtcccaataa tggagggtat gatgatgcag atggggccta tattcatgta      540

cctcgagacc atctagctta tcgatatgag gtgctgaaaa ttattggcaa ggggagtttt      600

gggcaggtgg ccagggtcta tgatcacaaa cttcgacagt acgtggccct aaaaatggtg      660

cgcaatgaga agcgctttca tcgtcaagca gctgaggaga tccggatttt ggagcatctt      720

aagaaacagg ataaaactgg tagtatgaac gttatccaca tgctggaaag tttcacattc      780

cggaaccatg tttgcatggc ctttgaattg ctgagcatag acctttatga gctgattaaa      840

aaaaataagt ttcagggttt tagcgtccag ttggtacgca agtttgccca gtccatcttg      900

caatctttgg atgccctcca caaaaataag attattcact gcgatctgaa gccagaaaac      960

attctcctga aacaccacgg gcgcagttca accaaggtca ttgactttgg gtccagctgt     1020

ttcgagtacc agaagctcta cacatatatc cagtctcggt tctacagagc tccagaaatc     1080

atcttaggaa gccgctacag cacaccaatt gacatatgga gttttggctg catccttgca     1140

gaacttttaa caggacagcc tctcttccct ggagaggatg aaggagacca gttggcctgc     1200

atgatggagc ttctagggat gccaccacca aaacttctgg agcaatccaa acgtgccaag     1260

tactttatta attccaaggg cataccccgc tactgctctg tgactaccca ggcagatggg     1320

agggttgtgc ttgtgggggg tcgctcacgt aggggtaaaa agcggggtcc cccaggcagc     1380

aaagactggg ggacagcact gaaagggtgt gatgactact tgtttataga gttcttgaaa     1440

aggtgtcttc actgggaccc ctctgcccgc ttgaccccag ctcaagcatt aagacaccct     1500

tggattagca agtctgtccc cagacctctc accaccatag acaaggtgtc agggaaacgg     1560

gtagttaatc ctgcaagtgc tttccaggga ttgggttcta agctgcctcc agttgttgga     1620

atagccaata agcttaaagc taacttaatg tcagaaacca atggtagtat acccctatgc     1680

agtgtattgc caaaactgat tagctag                                         1707


<210>  43
<211>  520
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK4 protein isoform 1

<400>  43

Met Pro Ala Ser Glu Leu Lys Ala Ser Glu Ile Pro Phe His Pro Ser 
1               5                   10                  15      


Ile Lys Thr Gln Asp Pro Lys Ala Glu Glu Lys Ser Pro Lys Lys Gln 
            20                  25                  30          


Lys Val Thr Leu Thr Ala Ala Glu Ala Leu Lys Leu Phe Lys Asn Gln 
        35                  40                  45              


Leu Ser Pro Tyr Glu Gln Ser Glu Ile Leu Gly Tyr Ala Glu Leu Trp 
    50                  55                  60                  


Phe Leu Gly Leu Glu Ala Lys Lys Leu Asp Thr Ala Pro Glu Lys Phe 
65                  70                  75                  80  


Ser Lys Thr Ser Phe Asp Asp Glu His Gly Phe Tyr Leu Lys Val Leu 
                85                  90                  95      


His Asp His Ile Ala Tyr Arg Tyr Glu Val Leu Glu Thr Ile Gly Lys 
            100                 105                 110         


Gly Ser Phe Gly Gln Val Ala Lys Cys Leu Asp His Lys Asn Asn Glu 
        115                 120                 125             


Leu Val Ala Leu Lys Ile Ile Arg Asn Lys Lys Arg Phe His Gln Gln 
    130                 135                 140                 


Ala Leu Met Glu Leu Lys Ile Leu Glu Ala Leu Arg Lys Lys Asp Lys 
145                 150                 155                 160 


Asp Asn Thr Tyr Asn Val Val His Met Lys Asp Phe Phe Tyr Phe Arg 
                165                 170                 175     


Asn His Phe Cys Ile Thr Phe Glu Leu Leu Gly Ile Asn Leu Tyr Glu 
            180                 185                 190         


Leu Met Lys Asn Asn Asn Phe Gln Gly Phe Ser Leu Ser Ile Val Arg 
        195                 200                 205             


Arg Phe Thr Leu Ser Val Leu Lys Cys Leu Gln Met Leu Ser Val Glu 
    210                 215                 220                 


Lys Ile Ile His Cys Asp Leu Lys Pro Glu Asn Ile Val Leu Tyr Gln 
225                 230                 235                 240 


Lys Gly Gln Ala Ser Val Lys Val Ile Asp Phe Gly Ser Ser Cys Tyr 
                245                 250                 255     


Glu His Gln Lys Val Tyr Thr Tyr Ile Gln Ser Arg Phe Tyr Arg Ser 
            260                 265                 270         


Pro Glu Val Ile Leu Gly His Pro Tyr Asp Val Ala Ile Asp Met Trp 
        275                 280                 285             


Ser Leu Gly Cys Ile Thr Ala Glu Leu Tyr Thr Gly Tyr Pro Leu Phe 
    290                 295                 300                 


Pro Gly Glu Asn Glu Val Glu Gln Leu Ala Cys Ile Met Glu Val Leu 
305                 310                 315                 320 


Gly Leu Pro Pro Ala Gly Phe Ile Gln Thr Ala Ser Arg Arg Gln Thr 
                325                 330                 335     


Phe Phe Asp Ser Lys Gly Phe Pro Lys Asn Ile Thr Asn Asn Arg Gly 
            340                 345                 350         


Lys Lys Arg Tyr Pro Asp Ser Lys Asp Leu Thr Met Val Leu Lys Thr 
        355                 360                 365             


Tyr Asp Thr Ser Phe Leu Asp Phe Leu Arg Arg Cys Leu Val Trp Glu 
    370                 375                 380                 


Pro Ser Leu Arg Met Thr Pro Asp Gln Ala Leu Lys His Ala Trp Ile 
385                 390                 395                 400 


His Gln Ser Arg Asn Leu Lys Pro Gln Pro Arg Pro Gln Thr Leu Arg 
                405                 410                 415     


Lys Ser Asn Ser Phe Phe Pro Ser Glu Thr Arg Lys Asp Lys Val Gln 
            420                 425                 430         


Gly Cys His His Ser Ser Arg Lys Ala Asp Glu Ile Thr Lys Glu Thr 
        435                 440                 445             


Thr Glu Lys Thr Lys Asp Ser Pro Thr Lys His Val Gln His Ser Gly 
    450                 455                 460                 


Asp Gln Gln Asp Cys Leu Gln His Gly Ala Asp Thr Val Gln Leu Pro 
465                 470                 475                 480 


Gln Leu Val Asp Ala Pro Lys Lys Ser Glu Ala Ala Val Gly Ala Glu 
                485                 490                 495     


Val Ser Met Thr Ser Pro Gly Gln Ser Lys Asn Phe Ser Leu Lys Asn 
            500                 505                 510         


Thr Asn Val Leu Pro Pro Ile Val 
        515                 520 


<210>  44
<211>  1563
<212>  DNA
<213>  Artificial

<220>
<223>  Human DYRK4 cDNA isoform 1

<400>  44
atgccggcct cagagctcaa ggcttcagaa atacctttcc accctagcat taaaacccag       60

gatcccaagg cagaggagaa gtcaccaaag aagcaaaagg tgactctgac agcggcagag      120

gccctaaagc tttttaagaa ccagctgtct ccatatgaac aaagtgaaat cctgggctac      180

gcggagctgt ggttcctggg tcttgaagcc aagaagctcg acacggctcc tgagaaattt      240

agcaagacga gttttgatga tgagcatggc ttctatctga aggtcctgca tgatcacatt      300

gcctaccgct atgaagttct ggagacaatc gggaaggggt cctttggaca ggtggccaag      360

tgcttggatc acaaaaacaa tgagctggtg gccctgaaaa tcatcaggaa caagaagagg      420

tttcaccagc aggccctgat ggagctgaag atcctggaag ctctcagaaa gaaggacaaa      480

gacaacacct acaatgtggt gcatatgaag gactttttct actttcgcaa tcacttctgc      540

atcacctttg agctcctggg aatcaacttg tatgagttga tgaagaataa caactttcaa      600

ggcttcagtc tgtccatagt tcggcgcttc actctctctg ttttgaagtg cttgcagatg      660

ctttcggtag agaaaatcat tcactgtgat ctcaagcccg aaaatatagt gctataccaa      720

aagggccaag cctctgttaa agtcattgac tttggatcaa gctgttatga acaccagaaa      780

gtatacacgt acatccaaag ccggttctac cgatccccag aagtgatcct gggccacccc      840

tacgacgtgg ccattgacat gtggagcctg ggctgcatca cggcggagtt gtacacgggc      900

taccccctgt tccccgggga gaatgaggtg gagcagctgg cctgcatcat ggaggtgctg      960

ggtctgccgc cagccggctt cattcagaca gcctccagga gacagacatt ctttgattcc     1020

aaaggttttc ctaaaaatat aaccaacaac agggggaaaa aaagataccc agattccaag     1080

gacctcacga tggtgctgaa aacctatgac accagcttcc tggactttct cagaaggtgt     1140

ttggtatggg aaccttctct tcgcatgacc ccggaccagg ccctcaagca tgcttggatt     1200

catcagtctc ggaacctcaa gccacagccc aggccccaga ccctgaggaa atccaattcc     1260

tttttcccct ctgagacaag gaaggacaag gttcaaggct gtcatcactc gagcagaaaa     1320

gcagatgaga tcaccaaaga gactacagag aaaacaaaag atagccccac gaagcatgtt     1380

cagcattcag gtgatcagca ggactgtctc cagcacggag ctgacactgt tcagctgcct     1440

caactggtag acgctcccaa gaagtcagag gcagctgtcg gggcggaggt gtccatgacc     1500

tccccaggac agagcaaaaa cttctccctc aagaacacaa acgttttacc ccctattgta     1560

tga                                                                   1563


<210>  45
<211>  519
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK4 protein isoform 2

<400>  45

Met Pro Ala Ser Glu Leu Lys Ala Ser Glu Ile Pro Phe His Pro Ser 
1               5                   10                  15      


Ile Lys Thr Gln Asp Pro Lys Ala Glu Glu Lys Ser Pro Lys Lys Gln 
            20                  25                  30          


Lys Val Thr Leu Thr Ala Ala Glu Ala Leu Lys Leu Phe Lys Asn Gln 
        35                  40                  45              


Leu Ser Pro Tyr Glu Gln Ser Glu Ile Leu Gly Tyr Ala Glu Leu Trp 
    50                  55                  60                  


Phe Leu Gly Leu Glu Ala Lys Lys Leu Asp Thr Ala Pro Glu Lys Phe 
65                  70                  75                  80  


Ser Lys Thr Ser Phe Asp Asp Glu His Gly Phe Tyr Leu Lys Val Leu 
                85                  90                  95      


His Asp His Ile Ala Tyr Arg Tyr Glu Val Leu Glu Thr Ile Gly Lys 
            100                 105                 110         


Gly Ser Phe Gly Gln Val Ala Lys Cys Leu Asp His Lys Asn Asn Glu 
        115                 120                 125             


Leu Val Ala Leu Lys Ile Ile Arg Asn Lys Lys Arg Phe His Gln Gln 
    130                 135                 140                 


Ala Leu Met Glu Leu Lys Ile Leu Glu Ala Leu Arg Lys Lys Asp Lys 
145                 150                 155                 160 


Asp Asn Thr Tyr Asn Val Val His Met Lys Asp Phe Phe Tyr Phe Arg 
                165                 170                 175     


Asn His Phe Cys Ile Thr Phe Glu Leu Leu Gly Ile Asn Leu Tyr Glu 
            180                 185                 190         


Leu Met Lys Asn Asn Asn Phe Gln Gly Phe Ser Leu Ser Ile Val Arg 
        195                 200                 205             


Arg Phe Thr Leu Ser Val Leu Lys Cys Leu Gln Met Leu Ser Val Glu 
    210                 215                 220                 


Lys Ile Ile His Cys Asp Leu Lys Pro Glu Asn Ile Val Leu Tyr Gln 
225                 230                 235                 240 


Lys Gly Gln Ala Ser Val Lys Val Ile Asp Phe Gly Ser Ser Cys Tyr 
                245                 250                 255     


Glu His Gln Lys Val Tyr Thr Tyr Ile Gln Ser Arg Phe Tyr Arg Ser 
            260                 265                 270         


Pro Glu Val Ile Leu Gly His Pro Tyr Asp Val Ala Ile Asp Met Trp 
        275                 280                 285             


Ser Leu Gly Cys Ile Thr Ala Glu Leu Tyr Thr Gly Tyr Pro Leu Phe 
    290                 295                 300                 


Pro Gly Glu Asn Glu Val Glu Gln Leu Ala Cys Ile Met Glu Val Leu 
305                 310                 315                 320 


Gly Leu Pro Pro Ala Gly Phe Ile Gln Thr Ala Ser Arg Arg Gln Thr 
                325                 330                 335     


Phe Phe Asp Ser Lys Gly Phe Pro Lys Asn Ile Thr Asn Asn Arg Gly 
            340                 345                 350         


Lys Lys Arg Tyr Pro Asp Ser Lys Asp Leu Thr Met Val Leu Lys Thr 
        355                 360                 365             


Tyr Asp Thr Ser Phe Leu Asp Phe Leu Arg Arg Cys Leu Val Trp Glu 
    370                 375                 380                 


Pro Ser Leu Arg Met Thr Pro Asp Gln Ala Leu Lys His Ala Trp Ile 
385                 390                 395                 400 


His Gln Ser Arg Asn Leu Lys Pro Gln Pro Arg Pro Gln Thr Leu Arg 
                405                 410                 415     


Lys Ser Asn Ser Phe Phe Pro Ser Glu Thr Arg Lys Asp Lys Val Gln 
            420                 425                 430         


Gly Cys His His Ser Ser Arg Lys Asp Glu Ile Thr Lys Glu Thr Thr 
        435                 440                 445             


Glu Lys Thr Lys Asp Ser Pro Thr Lys His Val Gln His Ser Gly Asp 
    450                 455                 460                 


Gln Gln Asp Cys Leu Gln His Gly Ala Asp Thr Val Gln Leu Pro Gln 
465                 470                 475                 480 


Leu Val Asp Ala Pro Lys Lys Ser Glu Ala Ala Val Gly Ala Glu Val 
                485                 490                 495     


Ser Met Thr Ser Pro Gly Gln Ser Lys Asn Phe Ser Leu Lys Asn Thr 
            500                 505                 510         


Asn Val Leu Pro Pro Ile Val 
        515                 


<210>  46
<211>  1560
<212>  DNA
<213>  Artificial

<220>
<223>  Human DYRK4 cDNA isoform 2

<400>  46
atgccggcct cagagctcaa ggcttcagaa atacctttcc accctagcat taaaacccag       60

gatcccaagg cagaggagaa gtcaccaaag aagcaaaagg tgactctgac agcggcagag      120

gccctaaagc tttttaagaa ccagctgtct ccatatgaac aaagtgaaat cctgggctac      180

gcggagctgt ggttcctggg tcttgaagcc aagaagctcg acacggctcc tgagaaattt      240

agcaagacga gttttgatga tgagcatggc ttctatctga aggtcctgca tgatcacatt      300

gcctaccgct atgaagttct ggagacaatc gggaaggggt cctttggaca ggtggccaag      360

tgcttggatc acaaaaacaa tgagctggtg gccctgaaaa tcatcaggaa caagaagagg      420

tttcaccagc aggccctgat ggagctgaag atcctggaag ctctcagaaa gaaggacaaa      480

gacaacacct acaatgtggt gcatatgaag gactttttct actttcgcaa tcacttctgc      540

atcacctttg agctcctggg aatcaacttg tatgagttga tgaagaataa caactttcaa      600

ggcttcagtc tgtccatagt tcggcgcttc actctctctg ttttgaagtg cttgcagatg      660

ctttcggtag agaaaatcat tcactgtgat ctcaagcccg aaaatatagt gctataccaa      720

aagggccaag cctctgttaa agtcattgac tttggatcaa gctgttatga acaccagaaa      780

gtatacacgt acatccaaag ccggttctac cgatccccag aagtgatcct gggccacccc      840

tacgacgtgg ccattgacat gtggagcctg ggctgcatca cggcggagtt gtacacgggc      900

taccccctgt tccccgggga gaatgaggtg gagcagctgg cctgcatcat ggaggtgctg      960

ggtctgccgc cagccggctt cattcagaca gcctccagga gacagacatt ctttgattcc     1020

aaaggttttc ctaaaaatat aaccaacaac agggggaaaa aaagataccc agattccaag     1080

gacctcacga tggtgctgaa aacctatgac accagcttcc tggactttct cagaaggtgt     1140

ttggtatggg aaccttctct tcgcatgacc ccggaccagg ccctcaagca tgcttggatt     1200

catcagtctc ggaacctcaa gccacagccc aggccccaga ccctgaggaa atccaattcc     1260

tttttcccct ctgagacaag gaaggacaag gttcaaggct gtcatcactc gagcagaaaa     1320

gatgagatca ccaaagagac tacagagaaa acaaaagata gccccacgaa gcatgttcag     1380

cattcaggtg atcagcagga ctgtctccag cacggagctg acactgttca gctgcctcaa     1440

ctggtagacg ctcccaagaa gtcagaggca gctgtcgggg cggaggtgtc catgacctcc     1500

ccaggacaga gcaaaaactt ctccctcaag aacacaaacg ttttaccccc tattgtatga     1560


<210>  47
<211>  635
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK4 protein isoform 3

<400>  47

Met Gln Leu Leu Pro Pro Pro Ile Arg Thr Gly Thr Lys Thr Gln Met 
1               5                   10                  15      


Asp Ala Lys Lys Pro Arg Lys Cys Asp Leu Thr Pro Phe Leu Val Leu 
            20                  25                  30          


Lys Ala Arg Lys Lys Gln Lys Phe Thr Ser Ala Lys Val Gly Ser Lys 
        35                  40                  45              


Leu Ser Val Gln Ile Gln Lys Pro Pro Ser Asn Ile Lys Asn Ser Arg 
    50                  55                  60                  


Met Thr Gln Val Phe His Lys Asn Thr Ser Val Thr Ser Leu Pro Phe 
65                  70                  75                  80  


Val Asp Thr Lys Gly Lys Lys Asn Thr Val Ser Phe Pro His Ile Ser 
                85                  90                  95      


Lys Lys Val Leu Leu Lys Ser Ser Leu Leu Tyr Gln Glu Asn Gln Ala 
            100                 105                 110         


His Asn Gln Met Pro Ala Ser Glu Leu Lys Ala Ser Glu Ile Pro Phe 
        115                 120                 125             


His Pro Ser Ile Lys Thr Gln Asp Pro Lys Ala Glu Glu Lys Ser Pro 
    130                 135                 140                 


Lys Lys Gln Lys Val Thr Leu Thr Ala Ala Glu Ala Leu Lys Leu Phe 
145                 150                 155                 160 


Lys Asn Gln Leu Ser Pro Tyr Glu Gln Ser Glu Ile Leu Gly Tyr Ala 
                165                 170                 175     


Glu Leu Trp Phe Leu Gly Leu Glu Ala Lys Lys Leu Asp Thr Ala Pro 
            180                 185                 190         


Glu Lys Phe Ser Lys Thr Ser Phe Asp Asp Glu His Gly Phe Tyr Leu 
        195                 200                 205             


Lys Val Leu His Asp His Ile Ala Tyr Arg Tyr Glu Val Leu Glu Thr 
    210                 215                 220                 


Ile Gly Lys Gly Ser Phe Gly Gln Val Ala Lys Cys Leu Asp His Lys 
225                 230                 235                 240 


Asn Asn Glu Leu Val Ala Leu Lys Ile Ile Arg Asn Lys Lys Arg Phe 
                245                 250                 255     


His Gln Gln Ala Leu Met Glu Leu Lys Ile Leu Glu Ala Leu Arg Lys 
            260                 265                 270         


Lys Asp Lys Asp Asn Thr Tyr Asn Val Val His Met Lys Asp Phe Phe 
        275                 280                 285             


Tyr Phe Arg Asn His Phe Cys Ile Thr Phe Glu Leu Leu Gly Ile Asn 
    290                 295                 300                 


Leu Tyr Glu Leu Met Lys Asn Asn Asn Phe Gln Gly Phe Ser Leu Ser 
305                 310                 315                 320 


Ile Val Arg Arg Phe Thr Leu Ser Val Leu Lys Cys Leu Gln Met Leu 
                325                 330                 335     


Ser Val Glu Lys Ile Ile His Cys Asp Leu Lys Pro Glu Asn Ile Val 
            340                 345                 350         


Leu Tyr Gln Lys Gly Gln Ala Ser Val Lys Val Ile Asp Phe Gly Ser 
        355                 360                 365             


Ser Cys Tyr Glu His Gln Lys Val Tyr Thr Tyr Ile Gln Ser Arg Phe 
    370                 375                 380                 


Tyr Arg Ser Pro Glu Val Ile Leu Gly His Pro Tyr Asp Val Ala Ile 
385                 390                 395                 400 


Asp Met Trp Ser Leu Gly Cys Ile Thr Ala Glu Leu Tyr Thr Gly Tyr 
                405                 410                 415     


Pro Leu Phe Pro Gly Glu Asn Glu Val Glu Gln Leu Ala Cys Ile Met 
            420                 425                 430         


Glu Val Leu Gly Leu Pro Pro Ala Gly Phe Ile Gln Thr Ala Ser Arg 
        435                 440                 445             


Arg Gln Thr Phe Phe Asp Ser Lys Gly Phe Pro Lys Asn Ile Thr Asn 
    450                 455                 460                 


Asn Arg Gly Lys Lys Arg Tyr Pro Asp Ser Lys Asp Leu Thr Met Val 
465                 470                 475                 480 


Leu Lys Thr Tyr Asp Thr Ser Phe Leu Asp Phe Leu Arg Arg Cys Leu 
                485                 490                 495     


Val Trp Glu Pro Ser Leu Arg Met Thr Pro Asp Gln Ala Leu Lys His 
            500                 505                 510         


Ala Trp Ile His Gln Ser Arg Asn Leu Lys Pro Gln Pro Arg Pro Gln 
        515                 520                 525             


Thr Leu Arg Lys Ser Asn Ser Phe Phe Pro Ser Glu Thr Arg Lys Asp 
    530                 535                 540                 


Lys Val Gln Gly Cys His His Ser Ser Arg Lys Ala Asp Glu Ile Thr 
545                 550                 555                 560 


Lys Glu Thr Thr Glu Lys Thr Lys Asp Ser Pro Thr Lys His Val Gln 
                565                 570                 575     


His Ser Gly Asp Gln Gln Asp Cys Leu Gln His Gly Ala Asp Thr Val 
            580                 585                 590         


Gln Leu Pro Gln Leu Val Asp Ala Pro Lys Lys Ser Glu Ala Ala Val 
        595                 600                 605             


Gly Ala Glu Val Ser Met Thr Ser Pro Gly Gln Ser Lys Asn Phe Ser 
    610                 615                 620                 


Leu Lys Asn Thr Asn Val Leu Pro Pro Ile Val 
625                 630                 635 


<210>  48
<211>  644
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK4 protein isoform 4

<400>  48

Met Gln Leu Leu Pro Pro Pro Ile Arg Thr Gly Thr Lys Thr Gln Met 
1               5                   10                  15      


Asp Ala Lys Lys Pro Arg Lys Cys Asp Leu Thr Pro Phe Leu Val Leu 
            20                  25                  30          


Lys Ala Arg Lys Lys Gln Lys Phe Thr Ser Ala Lys Gly Pro Thr Leu 
        35                  40                  45              


Ser Glu Ile Tyr Met Val Gly Ser Lys Leu Ser Val Gln Ile Gln Lys 
    50                  55                  60                  


Pro Pro Ser Asn Ile Lys Asn Ser Arg Met Thr Gln Val Phe His Lys 
65                  70                  75                  80  


Asn Thr Ser Val Thr Ser Leu Pro Phe Val Asp Thr Lys Gly Lys Lys 
                85                  90                  95      


Asn Thr Val Ser Phe Pro His Ile Ser Lys Lys Val Leu Leu Lys Ser 
            100                 105                 110         


Ser Leu Leu Tyr Gln Glu Asn Gln Ala His Asn Gln Met Pro Ala Ser 
        115                 120                 125             


Glu Leu Lys Ala Ser Glu Ile Pro Phe His Pro Ser Ile Lys Thr Gln 
    130                 135                 140                 


Asp Pro Lys Ala Glu Glu Lys Ser Pro Lys Lys Gln Lys Val Thr Leu 
145                 150                 155                 160 


Thr Ala Ala Glu Ala Leu Lys Leu Phe Lys Asn Gln Leu Ser Pro Tyr 
                165                 170                 175     


Glu Gln Ser Glu Ile Leu Gly Tyr Ala Glu Leu Trp Phe Leu Gly Leu 
            180                 185                 190         


Glu Ala Lys Lys Leu Asp Thr Ala Pro Glu Lys Phe Ser Lys Thr Ser 
        195                 200                 205             


Phe Asp Asp Glu His Gly Phe Tyr Leu Lys Val Leu His Asp His Ile 
    210                 215                 220                 


Ala Tyr Arg Tyr Glu Val Leu Glu Thr Ile Gly Lys Gly Ser Phe Gly 
225                 230                 235                 240 


Gln Val Ala Lys Cys Leu Asp His Lys Asn Asn Glu Leu Val Ala Leu 
                245                 250                 255     


Lys Ile Ile Arg Asn Lys Lys Arg Phe His Gln Gln Ala Leu Met Glu 
            260                 265                 270         


Leu Lys Ile Leu Glu Ala Leu Arg Lys Lys Asp Lys Asp Asn Thr Tyr 
        275                 280                 285             


Asn Val Val His Met Lys Asp Phe Phe Tyr Phe Arg Asn His Phe Cys 
    290                 295                 300                 


Ile Thr Phe Glu Leu Leu Gly Ile Asn Leu Tyr Glu Leu Met Lys Asn 
305                 310                 315                 320 


Asn Asn Phe Gln Gly Phe Ser Leu Ser Ile Val Arg Arg Phe Thr Leu 
                325                 330                 335     


Ser Val Leu Lys Cys Leu Gln Met Leu Ser Val Glu Lys Ile Ile His 
            340                 345                 350         


Cys Asp Leu Lys Pro Glu Asn Ile Val Leu Tyr Gln Lys Gly Gln Ala 
        355                 360                 365             


Ser Val Lys Val Ile Asp Phe Gly Ser Ser Cys Tyr Glu His Gln Lys 
    370                 375                 380                 


Val Tyr Thr Tyr Ile Gln Ser Arg Phe Tyr Arg Ser Pro Glu Val Ile 
385                 390                 395                 400 


Leu Gly His Pro Tyr Asp Val Ala Ile Asp Met Trp Ser Leu Gly Cys 
                405                 410                 415     


Ile Thr Ala Glu Leu Tyr Thr Gly Tyr Pro Leu Phe Pro Gly Glu Asn 
            420                 425                 430         


Glu Val Glu Gln Leu Ala Cys Ile Met Glu Val Leu Gly Leu Pro Pro 
        435                 440                 445             


Ala Gly Phe Ile Gln Thr Ala Ser Arg Arg Gln Thr Phe Phe Asp Ser 
    450                 455                 460                 


Lys Gly Phe Pro Lys Asn Ile Thr Asn Asn Arg Gly Lys Lys Arg Tyr 
465                 470                 475                 480 


Pro Asp Ser Lys Asp Leu Thr Met Val Leu Lys Thr Tyr Asp Thr Ser 
                485                 490                 495     


Phe Leu Asp Phe Leu Arg Arg Cys Leu Val Trp Glu Pro Ser Leu Arg 
            500                 505                 510         


Met Thr Pro Asp Gln Ala Leu Lys His Ala Trp Ile His Gln Ser Arg 
        515                 520                 525             


Asn Leu Lys Pro Gln Pro Arg Pro Gln Thr Leu Arg Lys Ser Asn Ser 
    530                 535                 540                 


Phe Phe Pro Ser Glu Thr Arg Lys Asp Lys Val Gln Gly Cys His His 
545                 550                 555                 560 


Ser Ser Arg Lys Ala Asp Glu Ile Thr Lys Glu Thr Thr Glu Lys Thr 
                565                 570                 575     


Lys Asp Ser Pro Thr Lys His Val Gln His Ser Gly Asp Gln Gln Asp 
            580                 585                 590         


Cys Leu Gln His Gly Ala Asp Thr Val Gln Leu Pro Gln Leu Val Asp 
        595                 600                 605             


Ala Pro Lys Lys Ser Glu Ala Ala Val Gly Ala Glu Val Ser Met Thr 
    610                 615                 620                 


Ser Pro Gly Gln Ser Lys Asn Phe Ser Leu Lys Asn Thr Asn Val Leu 
625                 630                 635                 640 


Pro Pro Ile Val 
                


<210>  49
<211>  517
<212>  PRT
<213>  Artificial

<220>
<223>  Human DYRK4 protein isoform 5

<400>  49

Met Pro Ala Ser Glu Leu Lys Ala Ser Glu Ile Pro Phe His Pro Ser 
1               5                   10                  15      


Ile Lys Thr Gln Asp Pro Lys Ala Glu Glu Lys Ser Pro Lys Lys Gln 
            20                  25                  30          


Lys Val Thr Leu Thr Ala Ala Glu Ala Leu Lys Leu Phe Lys Asn Gln 
        35                  40                  45              


Leu Ser Pro Tyr Glu Gln Ser Glu Ile Leu Gly Tyr Ala Glu Leu Trp 
    50                  55                  60                  


Phe Leu Gly Leu Glu Ala Lys Lys Leu Asp Thr Ala Pro Glu Lys Phe 
65                  70                  75                  80  


Ser Lys Thr Ser Phe Asp Asp Glu His Gly Phe Tyr Leu Lys Val Leu 
                85                  90                  95      


His Asp His Ile Ala Tyr Arg Tyr Glu Val Leu Glu Thr Ile Gly Lys 
            100                 105                 110         


Gly Ser Phe Gly Gln Val Ala Lys Cys Leu Asp His Lys Asn Asn Glu 
        115                 120                 125             


Leu Val Ala Leu Lys Ile Ile Arg Asn Lys Lys Arg Phe His Gln Gln 
    130                 135                 140                 


Ala Leu Met Glu Leu Lys Ile Leu Glu Ala Leu Arg Lys Lys Asp Lys 
145                 150                 155                 160 


Asp Asn Thr Tyr Asn Val Val His Met Lys Asp Phe Phe Tyr Phe Arg 
                165                 170                 175     


Asn His Phe Cys Ile Thr Phe Glu Leu Leu Gly Ile Asn Leu Tyr Glu 
            180                 185                 190         


Leu Met Lys Asn Asn Asn Phe Gln Gly Phe Ser Leu Ser Ile Val Arg 
        195                 200                 205             


Arg Phe Thr Leu Ser Val Leu Lys Cys Leu Gln Met Leu Ser Val Glu 
    210                 215                 220                 


Lys Ile Ile His Cys Asp Leu Lys Pro Glu Asn Ile Val Leu Tyr Gln 
225                 230                 235                 240 


Lys Gly Gln Ala Ser Val Lys Val Ile Asp Phe Gly Ser Ser Cys Tyr 
                245                 250                 255     


Glu His Gln Lys Val Tyr Thr Tyr Ile Gln Ser Arg Phe Tyr Arg Ser 
            260                 265                 270         


Pro Glu Val Ile Leu Gly His Pro Tyr Asp Val Ala Ile Asp Met Trp 
        275                 280                 285             


Ser Leu Gly Cys Ile Thr Ala Glu Leu Tyr Thr Gly Tyr Pro Leu Phe 
    290                 295                 300                 


Pro Gly Glu Asn Glu Val Glu Gln Leu Ala Cys Ile Met Glu Val Leu 
305                 310                 315                 320 


Gly Leu Pro Pro Ala Gly Phe Ile Gln Thr Ala Ser Arg Arg Gln Thr 
                325                 330                 335     


Phe Phe Asp Ser Lys Gly Phe Pro Lys Asn Ile Thr Asn Asn Arg Gly 
            340                 345                 350         


Lys Lys Arg Tyr Pro Asp Ser Lys Asp Leu Thr Met Val Leu Lys Thr 
        355                 360                 365             


Tyr Asp Thr Ser Phe Leu Asp Phe Leu Arg Arg Trp Glu Pro Ser Leu 
    370                 375                 380                 


Arg Met Thr Pro Asp Gln Ala Leu Lys His Ala Trp Ile His Gln Ser 
385                 390                 395                 400 


Arg Asn Leu Lys Pro Gln Pro Arg Pro Gln Thr Leu Arg Lys Ser Asn 
                405                 410                 415     


Ser Phe Phe Pro Ser Glu Thr Arg Lys Asp Lys Val Gln Gly Cys His 
            420                 425                 430         


His Ser Ser Arg Lys Ala Asp Glu Ile Thr Lys Glu Thr Thr Glu Lys 
        435                 440                 445             


Thr Lys Asp Ser Pro Thr Lys His Val Gln His Ser Gly Asp Gln Gln 
    450                 455                 460                 


Asp Cys Leu Gln His Gly Ala Asp Thr Val Gln Leu Pro Gln Leu Val 
465                 470                 475                 480 


Asp Ala Pro Lys Lys Ser Glu Ala Ala Val Gly Ala Glu Val Ser Met 
                485                 490                 495     


Thr Ser Pro Gly Gln Ser Lys Asn Phe Ser Leu Lys Asn Thr Asn Val 
            500                 505                 510         


Leu Pro Pro Ile Val 
        515         


