                         SEQUENCE LISTING

<110>  Cornell University
 
<120>  RECOMBINANT LUBRICINS, AND COMPOSITIONS AND METHODS FOR USING THE
        SAME

<130>  018617.01142

<150>  62/792,660
<151>  2019-01-15

<160>  99    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified lubricin repeat

<400>  1

Lys Glu Pro Ala Pro Thr Thr Pro 
1               5               


<210>  2
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified mucin repeat

<400>  2

Asp Ala Ala Thr Pro Ala Pro 
1               5           


<210>  3
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified mucin repeat

<400>  3

Asp Ala Ala Thr Pro Ala Pro Pro 
1               5               


<210>  4
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified mucin repeat

<400>  4

Pro Pro Ala Ser Thr Ser Ala Pro Gly 
1               5                   


<210>  5
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified mucin repeat

<400>  5

Pro Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly 
1               5                   10                  15      


Val Thr Ser Ala 
            20  


<210>  6
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  modified mucin repeat

<400>  6

Pro Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly 
1               5                   10                  15      


Val Thr Ala Ala 
            20  


<210>  7
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Modified mucin repeat

<400>  7

Pro Asp Ala Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly 
1               5                   10                  15      


Val Thr Ala Ala 
            20  


<210>  8
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  Unmodified mucin repeat

<400>  8

Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly 
1               5                   10                  15      


Val Thr Ser Ala 
            20  


<210>  9
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Modified mucin repeat

<400>  9

Lys Glu Pro Ala Pro Thr Pro 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Modified mucin repeat

<400>  10

Lys Glu Pro Ala Pro Thr Thr Thr Pro 
1               5                   


<210>  11
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  11

Cys Gln Cys Arg Arg Lys 
1               5       


<210>  12
<211>  37
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  12
ggcagctcag ctatggtgtc caagggcgag gagctgt                                37


<210>  13
<211>  39
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  13
ggcagctgag cccttataca gctcgtccat gccgtgagt                              39


<210>  14
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  14
tggaggagcc tcaggcatac tttattg                                           27


<210>  15
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  15
ccaccgccga ccgaggtgac atcctg                                            26


<210>  16
<211>  34
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  16
ccgaaagtag gaattcgggc ccgtttaaac ccgc                                   34


<210>  17
<211>  37
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  17
cggcactgac atctagagta ccacaacaaa gccaggc                                37


<210>  18
<211>  37
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  18
aggtagcgtc tcgtcccgcc tcaggcatac tttattg                                37


<210>  19
<211>  31
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  19
aggtagcgtc tcgtcgggag caggggtagc g                                      31


<210>  20
<211>  42
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  20
ggtagcgtct cgccgatgca gctactccag ctccggacag cc                          42


<210>  21
<211>  29
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  21
aggtagcgtc tcggggagca ggggtagcg                                         29


<210>  22
<211>  41
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  22
cttctgcgtc tcgtcccgcc tcaggcatac tttattggcg a                           41


<210>  23
<211>  37
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  23
cttctgcgtc tcgtcgggag gagctggtgt agccgcg                                37


<210>  24
<211>  39
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  24
cttctgcgtc tccccgatgc agctaccccg gctccaccc                              39


<210>  25
<211>  35
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  25
cttctgcgtc tccgggagga gctggtgtag ccgcg                                  35


<210>  26
<211>  62
<212>  PRT
<213>  artificial sequence

<220>
<223>  Flag Tag

<400>  26

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Asp Tyr Lys Asp Asp Asp Asp Leu Tyr 
    50                  55                  60          


<210>  27
<211>  193
<212>  DNA
<213>  artificial sequence

<220>
<223>  Flag tag cDNA

<400>  27
ggatccatga caccgggcac ccagtctcct ttcttcctgc tgctgctcct cacagtgctt       60

acagttgtta caggttctgg tcatgcaagc tctaccccag gtggagaaaa ggagacttcg      120

gctacccaga gaagttcagt gcccagctct actgagaaga atgctgatta caaggatgac      180

gacgacctgt aca                                                         193


<210>  28
<211>  170
<212>  PRT
<213>  artificial sequence

<220>
<223>  His-SUMO protein

<400>  28

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly His His His His His His Gly Ser Leu Gln 
            20                  25                  30          


Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val 
        35                  40                  45              


Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu 
    50                  55                  60                  


Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu 
65                  70                  75                  80  


Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Thr Phe Leu 
                85                  90                  95      


Tyr Asp Gly Ile Glu Ile Gln Ala Asp Gln Ala Pro Glu Asp Leu Asp 
            100                 105                 110         


Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly 
        115                 120                 125             


Gly Ser Gly Ser Gly His Ala Ser Ser Thr Pro Gly Gly Glu Lys Glu 
    130                 135                 140                 


Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser Thr Glu Lys Asn 
145                 150                 155                 160 


Ala Asp Tyr Lys Asp Asp Asp Asp Leu Tyr 
                165                 170 


<210>  29
<211>  522
<212>  DNA
<213>  artificial sequence

<220>
<223>  His-SUMO cDNA

<400>  29
gatccgccac catggagaca gacacactcc tgctatgggt actgctgctc tgggttccag       60

gttccactgg tgacggtcat caccatcatc atcacgggtc cctgcaggac tcagaagtca      120

atcaagaagc taagccagag gtcaagccag aagtcaagcc tgagactcac atcaatttaa      180

aggtgtccga tggatcttca gagatcttct tcaagatcaa aaagaccact cctttaagaa      240

ggctgatgga agcgttcgct aaaagacagg gtaaggaaat ggactcctta acgttcttgt      300

acgacggtat tgaaattcaa gctgatcagg cccctgaaga tttggacatg gaggataacg      360

atattattga ggctcacaga gaacagattg gaggtggctc cggctccggt catgcaagct      420

ctaccccagg tggagaaaag gagacttcgg ctacccagag aagttcagtg cccagctcta      480

ctgagaagaa tgctgattac aaggatgacg acgacctgta ca                         522


<210>  30
<211>  55
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic polymer backbone

<400>  30

Leu Tyr Met Asp Met Val Ala Val Ser Met Thr Ser Ser Val Leu Ser 
1               5                   10                  15      


Ser His Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val 
            20                  25                  30          


Thr Leu Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp 
        35                  40                  45              


Gly Gln Asp Val Thr Ser Val 
    50                  55  


<210>  31
<211>  63
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic mucin

<400>  31

Leu Tyr Met Asp Met Val Ala Val Ser Met Thr Ser Ser Val Leu Ser 
1               5                   10                  15      


Ser His Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val 
            20                  25                  30          


Thr Leu Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp 
        35                  40                  45              


Gly Gln Asp Val Thr Ser Val Gly Gly Gly Gly Gly Ala Ser Gly 
    50                  55                  60              


<210>  32
<211>  250
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant green fluorescent protein

<400>  32

Ser Gly Ser Ala Ser Gly Ser Ala Met Val Ser Lys Gly Glu Glu Leu 
1               5                   10                  15      


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
            20                  25                  30          


Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn 
        35                  40                  45              


Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro Val 
    50                  55                  60                  


Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Ser Phe 
65                  70                  75                  80  


Ser Arg Tyr Pro Asp His Met Lys Arg His Asp Phe Phe Lys Ser Ala 
                85                  90                  95      


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp 
            100                 105                 110         


Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
        115                 120                 125             


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
    130                 135                 140                 


Ile Leu Gly His Lys Leu Glu Tyr Asn Phe Asn Ser His Asn Val Tyr 
145                 150                 155                 160 


Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile 
                165                 170                 175     


Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
            180                 185                 190         


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
        195                 200                 205             


Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg 
    210                 215                 220                 


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His 
225                 230                 235                 240 


Gly Met Asp Glu Leu Tyr Lys Gly Ser Ala 
                245                 250 


<210>  33
<211>  222
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant transmembrane domain

<400>  33

Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr 
1               5                   10                  15      


Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro Ser His His Ser 
            20                  25                  30          


Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser 
        35                  40                  45              


Ser Thr His His Ser Ser Val Pro Pro Leu Thr Ser Ser Asn His Ser 
    50                  55                  60                  


Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe 
65                  70                  75                  80  


His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr 
                85                  90                  95      


Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln 
            100                 105                 110         


Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg 
        115                 120                 125             


Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr 
    130                 135                 140                 


Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu 
145                 150                 155                 160 


Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp 
                165                 170                 175     


Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp 
            180                 185                 190         


Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile 
        195                 200                 205             


Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys 
    210                 215                 220         


<210>  34
<211>  74
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant cytoplasmic domain

<400>  34

Ser Arg Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe 
1               5                   10                  15      


Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His 
            20                  25                  30          


Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr 
        35                  40                  45              


Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn 
    50                  55                  60                  


Pro Ala Val Ala Ala Ala Ser Ala Asn Leu 
65                  70                  


<210>  35
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant cytoplasmic domain

<400>  35

Ser Arg Cys Gln Cys Arg Arg Lys 
1               5               


<210>  36
<211>  1426
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant mucin

<400>  36

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Asp Tyr Lys Asp Asp Asp Asp Leu Tyr Met Asp 
    50                  55                  60                  


Met Val Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro 
65                  70                  75                  80  


Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro 
                85                  90                  95      


Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val 
            100                 105                 110         


Thr Ser Val Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        115                 120                 125             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    130                 135                 140                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
145                 150                 155                 160 


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                165                 170                 175     


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
            180                 185                 190         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        195                 200                 205             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    210                 215                 220                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
225                 230                 235                 240 


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                245                 250                 255     


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
            260                 265                 270         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        275                 280                 285             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    290                 295                 300                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
305                 310                 315                 320 


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                325                 330                 335     


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
            340                 345                 350         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        355                 360                 365             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    370                 375                 380                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
385                 390                 395                 400 


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                405                 410                 415     


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
            420                 425                 430         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        435                 440                 445             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    450                 455                 460                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
465                 470                 475                 480 


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                485                 490                 495     


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
            500                 505                 510         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        515                 520                 525             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    530                 535                 540                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
545                 550                 555                 560 


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                565                 570                 575     


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
            580                 585                 590         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        595                 600                 605             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    610                 615                 620                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
625                 630                 635                 640 


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                645                 650                 655     


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
            660                 665                 670         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        675                 680                 685             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    690                 695                 700                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
705                 710                 715                 720 


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                725                 730                 735     


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
            740                 745                 750         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        755                 760                 765             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    770                 775                 780                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
785                 790                 795                 800 


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                805                 810                 815     


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
            820                 825                 830         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        835                 840                 845             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    850                 855                 860                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
865                 870                 875                 880 


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                885                 890                 895     


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
            900                 905                 910         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        915                 920                 925             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    930                 935                 940                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Ala Ser Gly Ser Ala 
945                 950                 955                 960 


Ser Gly Ser Ala Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
                965                 970                 975     


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
            980                 985                 990         


Ser Val Arg Gly Glu Gly Glu Gly  Asp Ala Thr Asn Gly  Lys Leu Thr 
        995                 1000                 1005             


Leu Lys  Phe Ile Ser Thr Thr  Gly Lys Leu Pro Val  Pro Trp Pro 
    1010                 1015                 1020             


Thr Leu  Val Thr Thr Leu Thr  Tyr Gly Val Gln Ser  Phe Ser Arg 
    1025                 1030                 1035             


Tyr Pro  Asp His Met Lys Arg  His Asp Phe Phe Lys  Ser Ala Met 
    1040                 1045                 1050             


Pro Glu  Gly Tyr Val Gln Glu  Arg Thr Ile Ser Phe  Lys Asp Asp 
    1055                 1060                 1065             


Gly Thr  Tyr Lys Thr Arg Ala  Glu Val Lys Phe Glu  Gly Asp Thr 
    1070                 1075                 1080             


Leu Val  Asn Arg Ile Glu Leu  Lys Gly Ile Asp Phe  Lys Glu Asp 
    1085                 1090                 1095             


Gly Asn  Ile Leu Gly His Lys  Leu Glu Tyr Asn Phe  Asn Ser His 
    1100                 1105                 1110             


Asn Val  Tyr Ile Thr Ala Asp  Lys Gln Lys Asn Gly  Ile Lys Ala 
    1115                 1120                 1125             


Asn Phe  Lys Ile Arg His Asn  Val Glu Asp Gly Ser  Val Gln Leu 
    1130                 1135                 1140             


Ala Asp  His Tyr Gln Gln Asn  Thr Pro Ile Gly Asp  Gly Pro Val 
    1145                 1150                 1155             


Leu Leu  Pro Asp Asn His Tyr  Leu Ser Thr Gln Ser  Lys Leu Ser 
    1160                 1165                 1170             


Lys Asp  Pro Asn Glu Lys Arg  Asp His Met Val Leu  Leu Glu Phe 
    1175                 1180                 1185             


Val Thr  Ala Ala Gly Ile Thr  His Gly Met Asp Glu  Leu Tyr Lys 
    1190                 1195                 1200             


Gly Ser  Ala Ser Thr Leu Val  His Asn Gly Thr Ser  Ala Arg Ala 
    1205                 1210                 1215             


Thr Thr  Thr Pro Ala Ser Lys  Ser Thr Pro Phe Ser  Ile Pro Ser 
    1220                 1225                 1230             


His His  Ser Asp Thr Pro Thr  Thr Leu Ala Ser His  Ser Thr Lys 
    1235                 1240                 1245             


Thr Asp  Ala Ser Ser Thr His  His Ser Ser Val Pro  Pro Leu Thr 
    1250                 1255                 1260             


Ser Ser  Asn His Ser Thr Ser  Pro Gln Leu Ser Thr  Gly Val Ser 
    1265                 1270                 1275             


Phe Phe  Phe Leu Ser Phe His  Ile Ser Asn Leu Gln  Phe Asn Ser 
    1280                 1285                 1290             


Ser Leu  Glu Asp Pro Ser Thr  Asp Tyr Tyr Gln Glu  Leu Gln Arg 
    1295                 1300                 1305             


Asp Ile  Ser Glu Met Phe Leu  Gln Ile Tyr Lys Gln  Gly Gly Phe 
    1310                 1315                 1320             


Leu Gly  Leu Ser Asn Ile Lys  Phe Arg Pro Gly Ser  Val Val Val 
    1325                 1330                 1335             


Gln Leu  Thr Leu Ala Phe Arg  Glu Gly Thr Ile Asn  Val His Asp 
    1340                 1345                 1350             


Val Glu  Thr Gln Phe Asn Gln  Tyr Lys Thr Glu Ala  Ala Ser Arg 
    1355                 1360                 1365             


Tyr Asn  Leu Thr Ile Ser Asp  Val Ser Val Ser Asp  Val Pro Phe 
    1370                 1375                 1380             


Pro Phe  Ser Ala Gln Ser Gly  Ala Gly Val Pro Gly  Trp Gly Ile 
    1385                 1390                 1395             


Ala Leu  Leu Val Leu Val Cys  Val Leu Val Ala Leu  Ala Ile Val 
    1400                 1405                 1410             


Tyr Leu  Ile Ala Leu Ala Val  Cys Gln Cys Arg Arg  Lys 
    1415                 1420                 1425     


<210>  37
<211>  1005
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant mucin

<400>  37

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Asp Tyr Lys Asp Asp Asp Asp Leu Tyr Met Asp 
    50                  55                  60                  


Met Val Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro 
65                  70                  75                  80  


Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro 
                85                  90                  95      


Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val 
            100                 105                 110         


Thr Ser Val Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        115                 120                 125             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    130                 135                 140                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
145                 150                 155                 160 


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                165                 170                 175     


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
            180                 185                 190         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        195                 200                 205             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    210                 215                 220                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
225                 230                 235                 240 


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                245                 250                 255     


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
            260                 265                 270         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        275                 280                 285             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    290                 295                 300                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
305                 310                 315                 320 


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                325                 330                 335     


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
            340                 345                 350         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        355                 360                 365             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    370                 375                 380                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
385                 390                 395                 400 


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                405                 410                 415     


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
            420                 425                 430         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        435                 440                 445             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
    450                 455                 460                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
465                 470                 475                 480 


Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                485                 490                 495     


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
            500                 505                 510         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
        515                 520                 525             


Ala His Gly Val Thr Ser Ala Ala Ser Gly Ser Ala Ser Gly Ser Ala 
    530                 535                 540                 


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
545                 550                 555                 560 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
                565                 570                 575     


Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile 
            580                 585                 590         


Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
        595                 600                 605             


Leu Thr Tyr Gly Val Gln Ser Phe Ser Arg Tyr Pro Asp His Met Lys 
    610                 615                 620                 


Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
625                 630                 635                 640 


Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu 
                645                 650                 655     


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
            660                 665                 670         


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
        675                 680                 685             


Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
    690                 695                 700                 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser 
705                 710                 715                 720 


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
                725                 730                 735     


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
            740                 745                 750         


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
        755                 760                 765             


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Gly 
    770                 775                 780                 


Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr 
785                 790                 795                 800 


Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro Ser His His Ser 
                805                 810                 815     


Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser 
            820                 825                 830         


Ser Thr His His Ser Ser Val Pro Pro Leu Thr Ser Ser Asn His Ser 
        835                 840                 845             


Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe 
    850                 855                 860                 


His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr 
865                 870                 875                 880 


Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln 
                885                 890                 895     


Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg 
            900                 905                 910         


Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr 
        915                 920                 925             


Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu 
    930                 935                 940                 


Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp 
945                 950                 955                 960 


Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp 
                965                 970                 975     


Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile 
            980                 985                 990         


Val Tyr Leu Ile Ala Leu Ala Val  Cys Gln Cys Arg Arg  
        995                 1000                 1005 


<210>  38
<211>  591
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant mucin

<400>  38

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Asp Tyr Lys Asp Asp Asp Asp Leu Tyr Met Asp 
    50                  55                  60                  


Met Val Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro 
65                  70                  75                  80  


Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro 
                85                  90                  95      


Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val 
            100                 105                 110         


Thr Ser Val Gly Gly Gly Gly Gly Ala Ser Gly Ser Ala Ser Gly Ser 
        115                 120                 125             


Ala Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
    130                 135                 140                 


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg 
145                 150                 155                 160 


Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe 
                165                 170                 175     


Ile Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
            180                 185                 190         


Thr Leu Thr Tyr Gly Val Gln Ser Phe Ser Arg Tyr Pro Asp His Met 
        195                 200                 205             


Lys Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
    210                 215                 220                 


Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala 
225                 230                 235                 240 


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
                245                 250                 255     


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
            260                 265                 270         


Tyr Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys 
        275                 280                 285             


Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly 
    290                 295                 300                 


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
305                 310                 315                 320 


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys 
                325                 330                 335     


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
            340                 345                 350         


Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
        355                 360                 365             


Gly Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala Arg Ala Thr 
    370                 375                 380                 


Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro Ser His His 
385                 390                 395                 400 


Ser Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys Thr Asp Ala 
                405                 410                 415     


Ser Ser Thr His His Ser Ser Val Pro Pro Leu Thr Ser Ser Asn His 
            420                 425                 430         


Ser Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
        435                 440                 445             


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
    450                 455                 460                 


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
465                 470                 475                 480 


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
                485                 490                 495     


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
            500                 505                 510         


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
        515                 520                 525             


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
    530                 535                 540                 


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
545                 550                 555                 560 


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
                565                 570                 575     


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys 
            580                 585                 590     


<210>  39
<211>  1005
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant mucin

<400>  39

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Asp Tyr Lys Asp Asp Asp Asp Leu Tyr Met Asp 
    50                  55                  60                  


Met Val Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro 
65                  70                  75                  80  


Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro 
                85                  90                  95      


Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val 
            100                 105                 110         


Thr Ser Val Pro Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        115                 120                 125             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala 
    130                 135                 140                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
145                 150                 155                 160 


Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                165                 170                 175     


Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val 
            180                 185                 190         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        195                 200                 205             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala 
    210                 215                 220                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
225                 230                 235                 240 


Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                245                 250                 255     


Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val 
            260                 265                 270         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        275                 280                 285             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala 
    290                 295                 300                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
305                 310                 315                 320 


Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                325                 330                 335     


Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val 
            340                 345                 350         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        355                 360                 365             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala 
    370                 375                 380                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
385                 390                 395                 400 


Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                405                 410                 415     


Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val 
            420                 425                 430         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        435                 440                 445             


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala 
    450                 455                 460                 


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
465                 470                 475                 480 


Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
                485                 490                 495     


Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val 
            500                 505                 510         


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        515                 520                 525             


Ala His Gly Val Thr Ser Ala Ala Ser Gly Ser Ala Ser Gly Ser Ala 
    530                 535                 540                 


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
545                 550                 555                 560 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
                565                 570                 575     


Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile 
            580                 585                 590         


Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
        595                 600                 605             


Leu Thr Tyr Gly Val Gln Ser Phe Ser Arg Tyr Pro Asp His Met Lys 
    610                 615                 620                 


Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
625                 630                 635                 640 


Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu 
                645                 650                 655     


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
            660                 665                 670         


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
        675                 680                 685             


Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
    690                 695                 700                 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser 
705                 710                 715                 720 


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
                725                 730                 735     


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
            740                 745                 750         


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
        755                 760                 765             


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Gly 
    770                 775                 780                 


Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr 
785                 790                 795                 800 


Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro Ser His His Ser 
                805                 810                 815     


Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser 
            820                 825                 830         


Ser Thr His His Ser Ser Val Pro Pro Leu Thr Ser Ser Asn His Ser 
        835                 840                 845             


Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe 
    850                 855                 860                 


His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr 
865                 870                 875                 880 


Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln 
                885                 890                 895     


Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg 
            900                 905                 910         


Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr 
        915                 920                 925             


Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu 
    930                 935                 940                 


Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp 
945                 950                 955                 960 


Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp 
                965                 970                 975     


Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile 
            980                 985                 990         


Val Tyr Leu Ile Ala Leu Ala Val  Cys Gln Cys Arg Arg  
        995                 1000                 1005 


<210>  40
<211>  1005
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant mucin

<400>  40

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Asp Tyr Lys Asp Asp Asp Asp Leu Tyr Met Asp 
    50                  55                  60                  


Met Val Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro 
65                  70                  75                  80  


Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro 
                85                  90                  95      


Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val 
            100                 105                 110         


Thr Ser Val Pro Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        115                 120                 125             


Ala His Gly Val Thr Ala Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala 
    130                 135                 140                 


Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro Asp Thr Arg Pro 
145                 150                 155                 160 


Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro 
                165                 170                 175     


Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val 
            180                 185                 190         


Thr Ala Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        195                 200                 205             


Ala His Gly Val Thr Ala Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala 
    210                 215                 220                 


Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro Asp Thr Arg Pro 
225                 230                 235                 240 


Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro 
                245                 250                 255     


Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val 
            260                 265                 270         


Thr Ala Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        275                 280                 285             


Ala His Gly Val Thr Ala Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala 
    290                 295                 300                 


Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro Asp Thr Arg Pro 
305                 310                 315                 320 


Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro 
                325                 330                 335     


Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val 
            340                 345                 350         


Thr Ala Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        355                 360                 365             


Ala His Gly Val Thr Ala Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala 
    370                 375                 380                 


Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro Asp Thr Arg Pro 
385                 390                 395                 400 


Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro 
                405                 410                 415     


Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val 
            420                 425                 430         


Thr Ala Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        435                 440                 445             


Ala His Gly Val Thr Ala Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala 
    450                 455                 460                 


Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro Asp Thr Arg Pro 
465                 470                 475                 480 


Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro 
                485                 490                 495     


Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val 
            500                 505                 510         


Thr Ala Ala Pro Asp Thr Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        515                 520                 525             


Ala His Gly Val Thr Ala Ala Ala Ser Gly Ser Ala Ser Gly Ser Ala 
    530                 535                 540                 


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
545                 550                 555                 560 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
                565                 570                 575     


Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile 
            580                 585                 590         


Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
        595                 600                 605             


Leu Thr Tyr Gly Val Gln Ser Phe Ser Arg Tyr Pro Asp His Met Lys 
    610                 615                 620                 


Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
625                 630                 635                 640 


Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu 
                645                 650                 655     


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
            660                 665                 670         


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
        675                 680                 685             


Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
    690                 695                 700                 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser 
705                 710                 715                 720 


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
                725                 730                 735     


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
            740                 745                 750         


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
        755                 760                 765             


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Gly 
    770                 775                 780                 


Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr 
785                 790                 795                 800 


Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro Ser His His Ser 
                805                 810                 815     


Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser 
            820                 825                 830         


Ser Thr His His Ser Ser Val Pro Pro Leu Thr Ser Ser Asn His Ser 
        835                 840                 845             


Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe 
    850                 855                 860                 


His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr 
865                 870                 875                 880 


Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln 
                885                 890                 895     


Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg 
            900                 905                 910         


Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr 
        915                 920                 925             


Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu 
    930                 935                 940                 


Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp 
945                 950                 955                 960 


Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp 
                965                 970                 975     


Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile 
            980                 985                 990         


Val Tyr Leu Ile Ala Leu Ala Val  Cys Gln Cys Arg Arg  
        995                 1000                 1005 


<210>  41
<211>  1006
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant mucin

<400>  41

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Asp Tyr Lys Asp Asp Asp Asp Leu Tyr Met Asp 
    50                  55                  60                  


Met Val Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro 
65                  70                  75                  80  


Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro 
                85                  90                  95      


Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val 
            100                 105                 110         


Thr Ser Val Pro Asp Ala Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        115                 120                 125             


Ala His Gly Val Thr Ala Ala Pro Asp Ala Arg Pro Ala Pro Gly Ala 
    130                 135                 140                 


Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro Asp Ala Arg Pro 
145                 150                 155                 160 


Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro 
                165                 170                 175     


Asp Ala Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val 
            180                 185                 190         


Thr Ala Ala Pro Asp Ala Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        195                 200                 205             


Ala His Gly Val Thr Ala Ala Pro Asp Ala Arg Pro Ala Pro Gly Ala 
    210                 215                 220                 


Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro Asp Ala Arg Pro 
225                 230                 235                 240 


Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro 
                245                 250                 255     


Asp Ala Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val 
            260                 265                 270         


Thr Ala Ala Pro Asp Ala Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        275                 280                 285             


Ala His Gly Val Thr Ala Ala Pro Asp Ala Arg Pro Ala Pro Gly Ala 
    290                 295                 300                 


Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro Asp Ala Arg Pro 
305                 310                 315                 320 


Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro 
                325                 330                 335     


Asp Ala Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val 
            340                 345                 350         


Thr Ala Ala Pro Asp Ala Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        355                 360                 365             


Ala His Gly Val Thr Ala Ala Pro Asp Ala Arg Pro Ala Pro Gly Ala 
    370                 375                 380                 


Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro Asp Ala Arg Pro 
385                 390                 395                 400 


Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro 
                405                 410                 415     


Asp Ala Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val 
            420                 425                 430         


Thr Ala Ala Pro Asp Ala Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        435                 440                 445             


Ala His Gly Val Thr Ala Ala Pro Asp Ala Arg Pro Ala Pro Gly Ala 
    450                 455                 460                 


Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro Asp Ala Arg Pro 
465                 470                 475                 480 


Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val Thr Ala Ala Pro 
                485                 490                 495     


Asp Ala Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro Ala His Gly Val 
            500                 505                 510         


Thr Ala Ala Pro Asp Ala Arg Pro Ala Pro Gly Ala Thr Ala Pro Pro 
        515                 520                 525             


Ala His Gly Val Thr Ala Ala Ala Ser Gly Ser Ala Ser Gly Ser Ala 
    530                 535                 540                 


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
545                 550                 555                 560 


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
                565                 570                 575     


Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile 
            580                 585                 590         


Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
        595                 600                 605             


Leu Thr Tyr Gly Val Gln Ser Phe Ser Arg Tyr Pro Asp His Met Lys 
    610                 615                 620                 


Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
625                 630                 635                 640 


Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu 
                645                 650                 655     


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
            660                 665                 670         


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
        675                 680                 685             


Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
    690                 695                 700                 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser 
705                 710                 715                 720 


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
                725                 730                 735     


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
            740                 745                 750         


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
        755                 760                 765             


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Gly 
    770                 775                 780                 


Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr 
785                 790                 795                 800 


Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro Ser His His Ser 
                805                 810                 815     


Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser 
            820                 825                 830         


Ser Thr His His Ser Ser Val Pro Pro Leu Thr Ser Ser Asn His Ser 
        835                 840                 845             


Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe 
    850                 855                 860                 


His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr 
865                 870                 875                 880 


Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln 
                885                 890                 895     


Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg 
            900                 905                 910         


Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr 
        915                 920                 925             


Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu 
    930                 935                 940                 


Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp 
945                 950                 955                 960 


Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp 
                965                 970                 975     


Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile 
            980                 985                 990         


Val Tyr Leu Ile Ala Leu Ala Val  Cys Gln Cys Arg Arg  Lys 
        995                 1000                 1005     


<210>  42
<211>  746
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant lubricin

<400>  42

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Asp Tyr Lys Asp Asp Asp Asp Leu Tyr Met Asp 
    50                  55                  60                  


Met Val Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro 
65                  70                  75                  80  


Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro 
                85                  90                  95      


Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val 
            100                 105                 110         


Thr Ser Val Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro 
        115                 120                 125             


Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro 
    130                 135                 140                 


Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro 
145                 150                 155                 160 


Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro 
                165                 170                 175     


Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro 
            180                 185                 190         


Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro 
        195                 200                 205             


Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro 
    210                 215                 220                 


Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro 
225                 230                 235                 240 


Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro 
                245                 250                 255     


Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro 
            260                 265                 270         


Thr Thr Pro Ala Ser Gly Ser Ala Ser Gly Ser Ala Met Val Ser Lys 
        275                 280                 285             


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
    290                 295                 300                 


Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly 
305                 310                 315                 320 


Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly 
                325                 330                 335     


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly 
            340                 345                 350         


Val Gln Ser Phe Ser Arg Tyr Pro Asp His Met Lys Arg His Asp Phe 
        355                 360                 365             


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser 
    370                 375                 380                 


Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
385                 390                 395                 400 


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
                405                 410                 415     


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe Asn Ser 
            420                 425                 430         


His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
        435                 440                 445             


Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala 
    450                 455                 460                 


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
465                 470                 475                 480 


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro 
                485                 490                 495     


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
            500                 505                 510         


Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Gly Ser Ala Ser Thr 
        515                 520                 525             


Leu Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser 
    530                 535                 540                 


Lys Ser Thr Pro Phe Ser Ile Pro Ser His His Ser Asp Thr Pro Thr 
545                 550                 555                 560 


Thr Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser Ser Thr His His 
                565                 570                 575     


Ser Ser Val Pro Pro Leu Thr Ser Ser Asn His Ser Thr Ser Pro Gln 
            580                 585                 590         


Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn 
        595                 600                 605             


Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln 
    610                 615                 620                 


Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln 
625                 630                 635                 640 


Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val 
                645                 650                 655     


Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His 
            660                 665                 670         


Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg 
        675                 680                 685             


Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro 
    690                 695                 700                 


Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu 
705                 710                 715                 720 


Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile 
                725                 730                 735     


Ala Leu Ala Val Cys Gln Cys Arg Arg Lys 
            740                 745     


<210>  43
<211>  866
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant lubricin

<400>  43

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Asp Tyr Lys Asp Asp Asp Asp Leu Tyr Met Asp 
    50                  55                  60                  


Met Val Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro 
65                  70                  75                  80  


Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro 
                85                  90                  95      


Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val 
            100                 105                 110         


Thr Ser Val Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala 
        115                 120                 125             


Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp 
    130                 135                 140                 


Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala 
145                 150                 155                 160 


Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro 
                165                 170                 175     


Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro 
            180                 185                 190         


Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala 
        195                 200                 205             


Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr 
    210                 215                 220                 


Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala 
225                 230                 235                 240 


Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp 
                245                 250                 255     


Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala 
            260                 265                 270         


Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro 
        275                 280                 285             


Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro 
    290                 295                 300                 


Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala 
305                 310                 315                 320 


Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr 
                325                 330                 335     


Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala 
            340                 345                 350         


Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp 
        355                 360                 365             


Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala 
    370                 375                 380                 


Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Ala Ser Gly Ser Ala 
385                 390                 395                 400 


Ser Gly Ser Ala Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
                405                 410                 415     


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
            420                 425                 430         


Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr 
        435                 440                 445             


Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
    450                 455                 460                 


Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Ser Phe Ser Arg Tyr Pro 
465                 470                 475                 480 


Asp His Met Lys Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
                485                 490                 495     


Tyr Val Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys 
            500                 505                 510         


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
        515                 520                 525             


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
    530                 535                 540                 


Lys Leu Glu Tyr Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp 
545                 550                 555                 560 


Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val 
                565                 570                 575     


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
            580                 585                 590         


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
        595                 600                 605             


Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
    610                 615                 620                 


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu 
625                 630                 635                 640 


Leu Tyr Lys Gly Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala 
                645                 650                 655     


Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro 
            660                 665                 670         


Ser His His Ser Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys 
        675                 680                 685             


Thr Asp Ala Ser Ser Thr His His Ser Ser Val Pro Pro Leu Thr Ser 
    690                 695                 700                 


Ser Asn His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe 
705                 710                 715                 720 


Phe Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu 
                725                 730                 735     


Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu 
            740                 745                 750         


Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn 
        755                 760                 765             


Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe 
    770                 775                 780                 


Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln 
785                 790                 795                 800 


Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val 
                805                 810                 815     


Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
            820                 825                 830         


Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val 
        835                 840                 845             


Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg 
    850                 855                 860                 


Arg Lys 
865     


<210>  44
<211>  1146
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant mucin

<400>  44

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Asp Tyr Lys Asp Asp Asp Asp Leu Tyr Met Asp 
    50                  55                  60                  


Met Val Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro 
65                  70                  75                  80  


Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro 
                85                  90                  95      


Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val 
            100                 105                 110         


Thr Ser Val Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala 
        115                 120                 125             


Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp 
    130                 135                 140                 


Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala 
145                 150                 155                 160 


Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro 
                165                 170                 175     


Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro 
            180                 185                 190         


Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala 
        195                 200                 205             


Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr 
    210                 215                 220                 


Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala 
225                 230                 235                 240 


Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp 
                245                 250                 255     


Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala 
            260                 265                 270         


Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro 
        275                 280                 285             


Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro 
    290                 295                 300                 


Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala 
305                 310                 315                 320 


Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr 
                325                 330                 335     


Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala 
            340                 345                 350         


Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp 
        355                 360                 365             


Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala 
    370                 375                 380                 


Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro 
385                 390                 395                 400 


Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro 
                405                 410                 415     


Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala 
            420                 425                 430         


Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr 
        435                 440                 445             


Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala 
    450                 455                 460                 


Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp 
465                 470                 475                 480 


Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala 
                485                 490                 495     


Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro 
            500                 505                 510         


Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro 
        515                 520                 525             


Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala 
    530                 535                 540                 


Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr 
545                 550                 555                 560 


Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala 
                565                 570                 575     


Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp 
            580                 585                 590         


Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala 
        595                 600                 605             


Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro 
    610                 615                 620                 


Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro 
625                 630                 635                 640 


Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala 
                645                 650                 655     


Ala Thr Pro Ala Pro Asp Ala Ala Thr Pro Ala Pro Asp Ala Ala Thr 
            660                 665                 670         


Pro Ala Pro Ala Ser Gly Ser Ala Ser Gly Ser Ala Met Val Ser Lys 
        675                 680                 685             


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
    690                 695                 700                 


Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly 
705                 710                 715                 720 


Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly 
                725                 730                 735     


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly 
            740                 745                 750         


Val Gln Ser Phe Ser Arg Tyr Pro Asp His Met Lys Arg His Asp Phe 
        755                 760                 765             


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser 
    770                 775                 780                 


Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
785                 790                 795                 800 


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
                805                 810                 815     


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe Asn Ser 
            820                 825                 830         


His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
        835                 840                 845             


Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala 
    850                 855                 860                 


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
865                 870                 875                 880 


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro 
                885                 890                 895     


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
            900                 905                 910         


Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Gly Ser Ala Ser Thr 
        915                 920                 925             


Leu Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser 
    930                 935                 940                 


Lys Ser Thr Pro Phe Ser Ile Pro Ser His His Ser Asp Thr Pro Thr 
945                 950                 955                 960 


Thr Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser Ser Thr His His 
                965                 970                 975     


Ser Ser Val Pro Pro Leu Thr Ser Ser Asn His Ser Thr Ser Pro Gln 
            980                 985                 990         


Leu Ser Thr Gly Val Ser Phe Phe  Phe Leu Ser Phe His  Ile Ser Asn 
        995                 1000                 1005             


Leu Gln  Phe Asn Ser Ser Leu  Glu Asp Pro Ser Thr  Asp Tyr Tyr 
    1010                 1015                 1020             


Gln Glu  Leu Gln Arg Asp Ile  Ser Glu Met Phe Leu  Gln Ile Tyr 
    1025                 1030                 1035             


Lys Gln  Gly Gly Phe Leu Gly  Leu Ser Asn Ile Lys  Phe Arg Pro 
    1040                 1045                 1050             


Gly Ser  Val Val Val Gln Leu  Thr Leu Ala Phe Arg  Glu Gly Thr 
    1055                 1060                 1065             


Ile Asn  Val His Asp Val Glu  Thr Gln Phe Asn Gln  Tyr Lys Thr 
    1070                 1075                 1080             


Glu Ala  Ala Ser Arg Tyr Asn  Leu Thr Ile Ser Asp  Val Ser Val 
    1085                 1090                 1095             


Ser Asp  Val Pro Phe Pro Phe  Ser Ala Gln Ser Gly  Ala Gly Val 
    1100                 1105                 1110             


Pro Gly  Trp Gly Ile Ala Leu  Leu Val Leu Val Cys  Val Leu Val 
    1115                 1120                 1125             


Ala Leu  Ala Ile Val Tyr Leu  Ile Ala Leu Ala Val  Cys Gln Cys 
    1130                 1135                 1140             


Arg Arg  Lys 
    1145     


<210>  45
<211>  906
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant mucin

<400>  45

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Asp Tyr Lys Asp Asp Asp Asp Leu Tyr Met Asp 
    50                  55                  60                  


Met Val Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro 
65                  70                  75                  80  


Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro 
                85                  90                  95      


Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val 
            100                 105                 110         


Thr Ser Val Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
        115                 120                 125             


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
    130                 135                 140                 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
145                 150                 155                 160 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
                165                 170                 175     


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
            180                 185                 190         


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
        195                 200                 205             


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
    210                 215                 220                 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
225                 230                 235                 240 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
                245                 250                 255     


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
            260                 265                 270         


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
        275                 280                 285             


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
    290                 295                 300                 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
305                 310                 315                 320 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
                325                 330                 335     


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
            340                 345                 350         


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
        355                 360                 365             


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
    370                 375                 380                 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
385                 390                 395                 400 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
                405                 410                 415     


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
            420                 425                 430         


Ala Pro Pro Ala Ser Gly Ser Ala Ser Gly Ser Ala Met Val Ser Lys 
        435                 440                 445             


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
    450                 455                 460                 


Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly 
465                 470                 475                 480 


Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly 
                485                 490                 495     


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly 
            500                 505                 510         


Val Gln Ser Phe Ser Arg Tyr Pro Asp His Met Lys Arg His Asp Phe 
        515                 520                 525             


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser 
    530                 535                 540                 


Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
545                 550                 555                 560 


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
                565                 570                 575     


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe Asn Ser 
            580                 585                 590         


His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
        595                 600                 605             


Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala 
    610                 615                 620                 


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
625                 630                 635                 640 


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro 
                645                 650                 655     


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
            660                 665                 670         


Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Gly Ser Ala Ser Thr 
        675                 680                 685             


Leu Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser 
    690                 695                 700                 


Lys Ser Thr Pro Phe Ser Ile Pro Ser His His Ser Asp Thr Pro Thr 
705                 710                 715                 720 


Thr Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser Ser Thr His His 
                725                 730                 735     


Ser Ser Val Pro Pro Leu Thr Ser Ser Asn His Ser Thr Ser Pro Gln 
            740                 745                 750         


Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn 
        755                 760                 765             


Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln 
    770                 775                 780                 


Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln 
785                 790                 795                 800 


Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val 
                805                 810                 815     


Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His 
            820                 825                 830         


Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg 
        835                 840                 845             


Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro 
    850                 855                 860                 


Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu 
865                 870                 875                 880 


Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile 
                885                 890                 895     


Ala Leu Ala Val Cys Gln Cys Arg Arg Lys 
            900                 905     


<210>  46
<211>  1226
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant mucin

<400>  46

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Asp Tyr Lys Asp Asp Asp Asp Leu Tyr Met Asp 
    50                  55                  60                  


Met Val Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro 
65                  70                  75                  80  


Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro 
                85                  90                  95      


Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val 
            100                 105                 110         


Thr Ser Val Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
        115                 120                 125             


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
    130                 135                 140                 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
145                 150                 155                 160 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
                165                 170                 175     


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
            180                 185                 190         


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
        195                 200                 205             


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
    210                 215                 220                 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
225                 230                 235                 240 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
                245                 250                 255     


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
            260                 265                 270         


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
        275                 280                 285             


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
    290                 295                 300                 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
305                 310                 315                 320 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
                325                 330                 335     


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
            340                 345                 350         


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
        355                 360                 365             


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
    370                 375                 380                 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
385                 390                 395                 400 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
                405                 410                 415     


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
            420                 425                 430         


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
        435                 440                 445             


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
    450                 455                 460                 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
465                 470                 475                 480 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
                485                 490                 495     


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
            500                 505                 510         


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
        515                 520                 525             


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
    530                 535                 540                 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
545                 550                 555                 560 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
                565                 570                 575     


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
            580                 585                 590         


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
        595                 600                 605             


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
    610                 615                 620                 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
625                 630                 635                 640 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
                645                 650                 655     


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
            660                 665                 670         


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
        675                 680                 685             


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
    690                 695                 700                 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
705                 710                 715                 720 


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
                725                 730                 735     


Ala Pro Pro Asp Ala Ala Thr Pro Ala Pro Pro Asp Ala Ala Thr Pro 
            740                 745                 750         


Ala Pro Pro Ala Ser Gly Ser Ala Ser Gly Ser Ala Met Val Ser Lys 
        755                 760                 765             


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
    770                 775                 780                 


Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly 
785                 790                 795                 800 


Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly 
                805                 810                 815     


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly 
            820                 825                 830         


Val Gln Ser Phe Ser Arg Tyr Pro Asp His Met Lys Arg His Asp Phe 
        835                 840                 845             


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser 
    850                 855                 860                 


Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
865                 870                 875                 880 


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
                885                 890                 895     


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe Asn Ser 
            900                 905                 910         


His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile Lys Ala 
        915                 920                 925             


Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser Val Gln Leu Ala 
    930                 935                 940                 


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
945                 950                 955                 960 


Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys Asp Pro 
                965                 970                 975     


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
            980                 985                 990         


Gly Ile Thr His Gly Met Asp Glu  Leu Tyr Lys Gly Ser  Ala Ser Thr 
        995                 1000                 1005             


Leu Val  His Asn Gly Thr Ser  Ala Arg Ala Thr Thr  Thr Pro Ala 
    1010                 1015                 1020             


Ser Lys  Ser Thr Pro Phe Ser  Ile Pro Ser His His  Ser Asp Thr 
    1025                 1030                 1035             


Pro Thr  Thr Leu Ala Ser His  Ser Thr Lys Thr Asp  Ala Ser Ser 
    1040                 1045                 1050             


Thr His  His Ser Ser Val Pro  Pro Leu Thr Ser Ser  Asn His Ser 
    1055                 1060                 1065             


Thr Ser  Pro Gln Leu Ser Thr  Gly Val Ser Phe Phe  Phe Leu Ser 
    1070                 1075                 1080             


Phe His  Ile Ser Asn Leu Gln  Phe Asn Ser Ser Leu  Glu Asp Pro 
    1085                 1090                 1095             


Ser Thr  Asp Tyr Tyr Gln Glu  Leu Gln Arg Asp Ile  Ser Glu Met 
    1100                 1105                 1110             


Phe Leu  Gln Ile Tyr Lys Gln  Gly Gly Phe Leu Gly  Leu Ser Asn 
    1115                 1120                 1125             


Ile Lys  Phe Arg Pro Gly Ser  Val Val Val Gln Leu  Thr Leu Ala 
    1130                 1135                 1140             


Phe Arg  Glu Gly Thr Ile Asn  Val His Asp Val Glu  Thr Gln Phe 
    1145                 1150                 1155             


Asn Gln  Tyr Lys Thr Glu Ala  Ala Ser Arg Tyr Asn  Leu Thr Ile 
    1160                 1165                 1170             


Ser Asp  Val Ser Val Ser Asp  Val Pro Phe Pro Phe  Ser Ala Gln 
    1175                 1180                 1185             


Ser Gly  Ala Gly Val Pro Gly  Trp Gly Ile Ala Leu  Leu Val Leu 
    1190                 1195                 1200             


Val Cys  Val Leu Val Ala Leu  Ala Ile Val Tyr Leu  Ile Ala Leu 
    1205                 1210                 1215             


Ala Val  Cys Gln Cys Arg Arg  Lys 
    1220                 1225     


<210>  47
<211>  946
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant mucin

<400>  47

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Asp Tyr Lys Asp Asp Asp Asp Leu Tyr Met Asp 
    50                  55                  60                  


Met Val Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro 
65                  70                  75                  80  


Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro 
                85                  90                  95      


Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val 
            100                 105                 110         


Thr Ser Val Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser 
        115                 120                 125             


Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro 
    130                 135                 140                 


Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly 
145                 150                 155                 160 


Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala 
                165                 170                 175     


Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr 
            180                 185                 190         


Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala 
        195                 200                 205             


Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro 
    210                 215                 220                 


Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro 
225                 230                 235                 240 


Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser 
                245                 250                 255     


Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser 
            260                 265                 270         


Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro 
        275                 280                 285             


Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly 
    290                 295                 300                 


Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala 
305                 310                 315                 320 


Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr 
                325                 330                 335     


Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala 
            340                 345                 350         


Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro 
        355                 360                 365             


Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro 
    370                 375                 380                 


Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser 
385                 390                 395                 400 


Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser 
                405                 410                 415     


Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro 
            420                 425                 430         


Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly 
        435                 440                 445             


Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala 
    450                 455                 460                 


Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Ala Ser Gly Ser Ala 
465                 470                 475                 480 


Ser Gly Ser Ala Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val 
                485                 490                 495     


Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe 
            500                 505                 510         


Ser Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr 
        515                 520                 525             


Leu Lys Phe Ile Ser Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr 
    530                 535                 540                 


Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Ser Phe Ser Arg Tyr Pro 
545                 550                 555                 560 


Asp His Met Lys Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly 
                565                 570                 575     


Tyr Val Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys 
            580                 585                 590         


Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile 
        595                 600                 605             


Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His 
    610                 615                 620                 


Lys Leu Glu Tyr Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp 
625                 630                 635                 640 


Lys Gln Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val 
                645                 650                 655     


Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro 
            660                 665                 670         


Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr 
        675                 680                 685             


Gln Ser Lys Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val 
    690                 695                 700                 


Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu 
705                 710                 715                 720 


Leu Tyr Lys Gly Ser Ala Ser Thr Leu Val His Asn Gly Thr Ser Ala 
                725                 730                 735     


Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe Ser Ile Pro 
            740                 745                 750         


Ser His His Ser Asp Thr Pro Thr Thr Leu Ala Ser His Ser Thr Lys 
        755                 760                 765             


Thr Asp Ala Ser Ser Thr His His Ser Ser Val Pro Pro Leu Thr Ser 
    770                 775                 780                 


Ser Asn His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val Ser Phe Phe 
785                 790                 795                 800 


Phe Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu 
                805                 810                 815     


Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu 
            820                 825                 830         


Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn 
        835                 840                 845             


Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe 
    850                 855                 860                 


Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln 
865                 870                 875                 880 


Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val 
                885                 890                 895     


Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly 
            900                 905                 910         


Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val 
        915                 920                 925             


Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg 
    930                 935                 940                 


Arg Lys 
945     


<210>  48
<211>  1306
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant mucin

<400>  48

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Asp Tyr Lys Asp Asp Asp Asp Leu Tyr Met Asp 
    50                  55                  60                  


Met Val Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His Ser Pro 
65                  70                  75                  80  


Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu Ala Pro 
                85                  90                  95      


Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln Asp Val 
            100                 105                 110         


Thr Ser Val Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser 
        115                 120                 125             


Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro 
    130                 135                 140                 


Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly 
145                 150                 155                 160 


Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala 
                165                 170                 175     


Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr 
            180                 185                 190         


Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala 
        195                 200                 205             


Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro 
    210                 215                 220                 


Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro 
225                 230                 235                 240 


Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser 
                245                 250                 255     


Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser 
            260                 265                 270         


Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro 
        275                 280                 285             


Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly 
    290                 295                 300                 


Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala 
305                 310                 315                 320 


Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr 
                325                 330                 335     


Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala 
            340                 345                 350         


Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro 
        355                 360                 365             


Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro 
    370                 375                 380                 


Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser 
385                 390                 395                 400 


Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser 
                405                 410                 415     


Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro 
            420                 425                 430         


Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly 
        435                 440                 445             


Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala 
    450                 455                 460                 


Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr 
465                 470                 475                 480 


Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala 
                485                 490                 495     


Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro 
            500                 505                 510         


Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro 
        515                 520                 525             


Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser 
    530                 535                 540                 


Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser 
545                 550                 555                 560 


Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro 
                565                 570                 575     


Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly 
            580                 585                 590         


Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala 
        595                 600                 605             


Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr 
    610                 615                 620                 


Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala 
625                 630                 635                 640 


Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro 
                645                 650                 655     


Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro 
            660                 665                 670         


Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser 
        675                 680                 685             


Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser 
    690                 695                 700                 


Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro 
705                 710                 715                 720 


Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly 
                725                 730                 735     


Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala 
            740                 745                 750         


Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr 
        755                 760                 765             


Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala 
    770                 775                 780                 


Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro 
785                 790                 795                 800 


Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser Ala Pro 
                805                 810                 815     


Gly Pro Pro Ala Ser Thr Ser Ala Pro Gly Pro Pro Ala Ser Thr Ser 
            820                 825                 830         


Ala Pro Gly Ala Ser Gly Ser Ala Ser Gly Ser Ala Met Val Ser Lys 
        835                 840                 845             


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
    850                 855                 860                 


Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu Gly Glu Gly 
865                 870                 875                 880 


Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Ser Thr Thr Gly 
                885                 890                 895     


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly 
            900                 905                 910         


Val Gln Ser Phe Ser Arg Tyr Pro Asp His Met Lys Arg His Asp Phe 
        915                 920                 925             


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Ser 
    930                 935                 940                 


Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
945                 950                 955                 960 


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
                965                 970                 975     


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Phe Asn Ser 
            980                 985                 990         


His Asn Val Tyr Ile Thr Ala Asp  Lys Gln Lys Asn Gly  Ile Lys Ala 
        995                 1000                 1005             


Asn Phe  Lys Ile Arg His Asn  Val Glu Asp Gly Ser  Val Gln Leu 
    1010                 1015                 1020             


Ala Asp  His Tyr Gln Gln Asn  Thr Pro Ile Gly Asp  Gly Pro Val 
    1025                 1030                 1035             


Leu Leu  Pro Asp Asn His Tyr  Leu Ser Thr Gln Ser  Lys Leu Ser 
    1040                 1045                 1050             


Lys Asp  Pro Asn Glu Lys Arg  Asp His Met Val Leu  Leu Glu Phe 
    1055                 1060                 1065             


Val Thr  Ala Ala Gly Ile Thr  His Gly Met Asp Glu  Leu Tyr Lys 
    1070                 1075                 1080             


Gly Ser  Ala Ser Thr Leu Val  His Asn Gly Thr Ser  Ala Arg Ala 
    1085                 1090                 1095             


Thr Thr  Thr Pro Ala Ser Lys  Ser Thr Pro Phe Ser  Ile Pro Ser 
    1100                 1105                 1110             


His His  Ser Asp Thr Pro Thr  Thr Leu Ala Ser His  Ser Thr Lys 
    1115                 1120                 1125             


Thr Asp  Ala Ser Ser Thr His  His Ser Ser Val Pro  Pro Leu Thr 
    1130                 1135                 1140             


Ser Ser  Asn His Ser Thr Ser  Pro Gln Leu Ser Thr  Gly Val Ser 
    1145                 1150                 1155             


Phe Phe  Phe Leu Ser Phe His  Ile Ser Asn Leu Gln  Phe Asn Ser 
    1160                 1165                 1170             


Ser Leu  Glu Asp Pro Ser Thr  Asp Tyr Tyr Gln Glu  Leu Gln Arg 
    1175                 1180                 1185             


Asp Ile  Ser Glu Met Phe Leu  Gln Ile Tyr Lys Gln  Gly Gly Phe 
    1190                 1195                 1200             


Leu Gly  Leu Ser Asn Ile Lys  Phe Arg Pro Gly Ser  Val Val Val 
    1205                 1210                 1215             


Gln Leu  Thr Leu Ala Phe Arg  Glu Gly Thr Ile Asn  Val His Asp 
    1220                 1225                 1230             


Val Glu  Thr Gln Phe Asn Gln  Tyr Lys Thr Glu Ala  Ala Ser Arg 
    1235                 1240                 1245             


Tyr Asn  Leu Thr Ile Ser Asp  Val Ser Val Ser Asp  Val Pro Phe 
    1250                 1255                 1260             


Pro Phe  Ser Ala Gln Ser Gly  Ala Gly Val Pro Gly  Trp Gly Ile 
    1265                 1270                 1275             


Ala Leu  Leu Val Leu Val Cys  Val Leu Val Ala Leu  Ala Ile Val 
    1280                 1285                 1290             


Tyr Leu  Ile Ala Leu Ala Val  Cys Gln Cys Arg Arg  Lys 
    1295                 1300                 1305     


<210>  49
<211>  42
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic transmembrane domain

<400>  49

Ala Ser Gly Ile Leu Tyr Trp Arg Asn Pro Thr Glu Ser Asp Ser Ile 
1               5                   10                  15      


Val Leu Ala Ile Ile Val Pro Ser Leu Leu Leu Leu Leu Cys Leu Ala 
            20                  25                  30          


Leu Leu Trp Tyr Met Arg Arg Arg Ser Met 
        35                  40          


<210>  50
<211>  2692
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA

<400>  50
tgtacatgga catggtcgct gtgagtatga ccagcagcgt actctccagc cacagccccg       60

gttcaggctc ctccaccact cagggacagg atgtcactct ggccccggcc acggaaccag      120

cttcaggttc agctgccacc tggggacagg atgtcacctc ggtcccggat acgcgacccg      180

ccccagggtc aacagcgccc ccagcccacg gcgttacatc tgcacctgac actagacctg      240

cgccaggatc aacagctcca ccggctcacg gggtcaccag tgcccccgac actcgaccag      300

ctccggggtc taccgctccc ccggctcatg gtgtcactag cgcgcctgac acacgcccgg      360

caccagggag tacggcccct cctgcgcacg gcgtaacttc agccccagat actcgacctg      420

ctccgggctc aacagccccg cctgcacatg gagttacatc agcccctgat actagaccgg      480

ctccaggttc aactgctccg ccagcacatg gtgtaacgtc tgcgcccgat actcgcccag      540

cacctgggtc cacagctccc cctgcgcatg gagtaacatc agcacctgat accagacctg      600

ccccgggcag cactgcaccc ccagcacatg gcgtaacatc agcaccagat actcgccccg      660

ctcctggttc cacggctccc cccgcgcatg gcgttacttc agctccagat acacggccgg      720

cacccggcag tacggctcca cccgcacatg gagtaacgag tgctccggac actcggcctg      780

ctccaggaag taccgcacct ccggcccatg gcgtgacaag tgctcccgac accagaccag      840

cgcctggttc aacagcaccg ccagctcatg gtgtaacctc agctcccgat actagacccg      900

cgccaggttc caccgctcca cctgcacacg gggtgacgag cgcacctgat acgcgcccgg      960

caccgggaag cacagcgcct cccgctcacg gagtcactag cgccccggat acaagacccg     1020

cacctggatc tacagctcct ccagctcacg gcgtcacgag tgcacccgat acacgaccgg     1080

ccccaggctc tacagcccca ccagcacatg gagtcacgag tgcacctgat actaggcccg     1140

ctccgggttc cacagcacct cctgcacatg gtgttacatc cgctcctgat acgagacccg     1200

ctccaggctc tactgcccca ccggcacacg gcgtgaccag tgctccagat acccggccag     1260

ctcctgggag tactgcgcct ccagctcatg gcgtcactag tgcacctgat acaagaccag     1320

cccccggttc cactgctcca ccagcccatg gtgtaacaag tgcaccggac acaaggccag     1380

cccctggtag tactgctcct cctgctcacg gtgttactag tgctcctgac accagacctg     1440

cccctggaag tactgcaccg cctgctcatg gagtcacatc agctccggat actcggccgg     1500

ctccgggatc aaccgctcct ccggctcatg gagtaacctc cgcaccggat actaggcctg     1560

caccggggag tacagcacca cctgctcatg gtgtgactag cgctcctgac actcgccccg     1620

ctcccggtag cactgccccc cctgcacatg gggtgacttc agctcctgat actcggcctg     1680

cacccggaag cacagccccc ccagctcatg gggtcacaag cgctccagat actaggccag     1740

cgccgggaag tacagcccct ccagcgcacg gtgtaacttc cgcgccagac acacgccctg     1800

ctcccggatc aacggcacct ccagcacacg gtgtgacgtc cgcacccgac acaagaccgg     1860

cacctggttc tactgcacct cccgcgcacg gagttacttc agcaccagat acaagacctg     1920

ctcctggctc aactgcccct ccggcgcatg gtgtaactag tgcgcctgat acacgcccag     1980

caccgggtag tacggcacca ccagctcatg gagttacgtc agctccagat acgcgccctg     2040

caccaggcag tacagctccg ccggcccacg gagtaactag cgcaccagat accaggccag     2100

cacccggtag taccgcgcct cctgcccatg gagtaacttc cgcccccgat acccgacctg     2160

cacctggcag taccgcccct cccgcccacg gggtaaccag tgcaccagac acgcggcccg     2220

caccaggatc tactgctccc ccagcgcatg gggtaacttc tgcaccagat acgaggcctg     2280

ccccaggtag tacagcgcca cctgcccacg gtgtcacctc cgctcctgat acaaggcctg     2340

cgcctggatc aactgcacca ccggcgcacg gggttacaag tgcccctgac acgagaccag     2400

caccaggttc tacggcgcct ccggcacatg gagtgactag tgccccagac actaggccgg     2460

ctcctggatc aaccgcacca cccgctcatg gagtgacatc agcgccagat actagaccag     2520

ctcccgggtc aactgcgccg cccgcccatg gggttacttc tgctccagac actcgcccag     2580

ccccaggatc aacggctcct cccgcacacg gagtgacctc tgctcctgat accaggccag     2640

ctccagggtc tacagcaccc cctgctcatg gggtaacatc tgccgcctca gg             2692


<210>  51
<211>  1432
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA

<400>  51
tgtacatgga catggtcgct gtgagtatga ccagcagcgt actctccagc cacagccccg       60

gttcaggctc ctccaccact cagggacagg atgtcactct ggccccggcc acggaaccag      120

cttcaggttc agctgccacc tggggacagg atgtcacctc ggtcccagac actcggcctg      180

caccgggatc aaccgcccca ccggctcatg gtgtaactag tgcgcctgat accagaccag      240

caccagggag tactgcacct cctgctcatg gggttactag tgcccccgat acgcgacctg      300

ctcctggaag cacagcaccg ccggctcacg gcgtaacgag tgctcctgac acaaggcccg      360

ctccagggtc aactgcacca cctgcacacg gagtgacatc agcgccagat acgagacctg      420

caccaggaag tacagcgccg ccagcccacg gagtaacttc agccccggac actaggccag      480

cacctggttc aacggcgcct ccagcccatg gagtaacatc cgctcccgat actcgtcctg      540

ctccgggttc cacagctcct cccgcacatg gggtgactag tgctccagat actcgcccag      600

cacccggtag taccgctcct cctgcacatg gcgtcactag tgcaccagac acgcgtccgg      660

ctcctgggtc tacagctcca ccagctcacg gagttaccag tgcacctgac actagacctg      720

cgcccggttc gacggctccg cccgcccatg gggtaacgtc tgcgccggat acacgccctg      780

cacctggatc taccgcacct ccggcccatg gtgtcacgag cgcacctgat acgaggcctg      840

ctccaggtag tactgctccc cccgctcatg gagttactag cgctcctgat actcgaccgg      900

cacctggcag cactgctcct ccagcacatg gtgttacatc ggctccagac acacgtcccg      960

cgccaggatc gactgctcca cccgctcacg gggtcacatc tgcacccgat acacggccag     1020

ctcccggttc cactgccccg cctgcccatg gcgttacttc ggcaccagat acccgacccg     1080

caccaggcag tacagcacct ccagcgcatg gtgtgacaag cgcccctgat acacgaccag     1140

ctccaggctc aacagcacca ccagcacacg gtgtaacctc agctccggat acccgtccag     1200

ctcctggtag tacagcccct cctgcgcacg gagtcacaag tgctcccgac acaagaccag     1260

ccccaggttc tactgcgcca cctgctcacg gtgttacctc tgccccagat acaagacctg     1320

cccctggctc tacggcaccc ccggcacatg gagtcacttc cgcaccggat actagaccag     1380

cgcctgggag tacggccccc ccagctcatg gcgtgacttc tgctgcctca gg             1432


<210>  52
<211>  772
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA

<400>  52
tgtacatgga catggtcgct gtgagtatga ccagcagcgt actctccagc cacagccccg       60

gttcaggctc ctccaccact cagggacagg atgtcactct ggccccggcc acggaaccag      120

cttcaggttc agctgccacc tggggacagg atgtcacctc ggtcccagat acaagaccgg      180

ccccaggatc tacggctcct ccggctcatg gagtcacttc tgctccagac acaaggcccg      240

cgccgggttc tacagcaccg cctgctcatg gtgttactag cgcacccgat acgagacctg      300

ctccgggatc aacggcacct cctgcccacg gggtaacatc tgcaccggac actcgccctg      360

cgcccggttc aaccgctcca cccgcacacg gagtgacaag cgctcctgac actagaccag      420

caccaggttc tacagcccca ccagcccatg gagttaccag tgcaccagat actaggccag      480

ctccaggtag tactgcaccc ccagctcatg gggttacatc agctcccgac acgcgaccag      540

ctcctggaag cactgcccct ccagctcacg gtgtgacctc agcacctgat acacgccctg      600

cacctggctc tactgctccc cccgctcatg gcgtaactag tgccccggat actcgacccg      660

cccctggttc cacagctccg ccagcacatg gtgtaacaag tgctcctgat acccgaccag      720

cgcctggaag taccgcacca cctgcacatg gagtaacttc agccgcctca gg              772


<210>  53
<211>  1432
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA

<400>  53
tgtacatgga catggtcgct gtgagtatga ccagcagcgt actctccagc cacagccccg       60

gttcaggctc ctccaccact cagggacagg atgtcactct ggccccggcc acggaaccag      120

cttcaggttc agctgccacc tggggacagg atgtcacctc ggtcccagat accagacctg      180

cgcctggagc cacagctcct cctgcccatg gcgtcacaag tgcccctgac acacgcccag      240

ctcccggggc tacagcccca cctgcacatg gtgttactag tgcaccagac accagaccgg      300

ctccgggagc cacggcaccc cccgctcatg gtgtcacttc cgcaccggat acgaggccag      360

cacctggggc cactgcgccg ccggcacatg gggtgactag tgcgccagat actcgccctg      420

ctccaggggc tactgcccct ccagctcatg gcgtaacctc agcgcctgat acccgaccag      480

cgccaggtgc cactgcaccg ccagcccatg gggtcactag tgctcctgac actagacctg      540

cacctggagc tacagcacct ccagcgcatg gtgtgacaag cgccccagac acgagaccag      600

cccccggtgc caccgctcct cccgcacatg gagttactag cgctccggac acaagaccgg      660

caccaggtgc gactgcacca ccggctcatg gagtaacttc agcaccagat acacggcctg      720

ctcccggcgc tacagctcca ccagcacatg gcgttacctc cgcacctgac acgaggcccg      780

ctccaggagc cactgctccc cctgcacacg gtgttacgtc agctccagat acgcggccag      840

ctccgggcgc aacagctccc ccggctcacg gtgtaaccag tgctcccgac acaaggcctg      900

cacccggagc aaccgcacct ccggcccatg gtgtaacaag tgcacctgat actaggcccg      960

cgcctggtgc tactgctcca cctgctcacg gcgtgacatc agcccctgat acgagacctg     1020

ccccaggggc aactgcacct cctgctcatg gggtaactag tgcccccgat acaagaccag     1080

caccgggagc gaccgccccc ccagcacacg gagtaacgag cgcacccgat actcgacctg     1140

caccaggagc gacggctcca cccgctcacg gagtcacgag tgctccagac actcgacctg     1200

ctcctggcgc gacagcacca ccagctcacg gggttactag tgctcctgat acacgacccg     1260

caccaggggc gactgctcct ccagcccacg gagttacatc tgccccggat acaaggccag     1320

cacccggtgc aactgctccg cccgcccatg gagtcacaag tgctccggat actagaccag     1380

ctcctggggc tacggcgcct cctgcgcacg gagtgacttc tgctgcctca gg             1432


<210>  54
<211>  1432
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA

<400>  54
tgtacatgga catggtcgct gtgagtatga ccagcagcgt actctccagc cacagccccg       60

gttcaggctc ctccaccact cagggacagg atgtcactct ggccccggcc acggaaccag      120

cttcaggttc agctgccacc tggggacagg atgtcacctc ggtcccagat gcaaggcctg      180

ccccgggagc gacagcacca ccagcacatg gagtgacggc cgccccagac gctcgaccgg      240

caccaggagc aactgctcct cccgcacatg gggtcactgc ggcccctgat gcgaggccgg      300

cacctggagc tactgctcca ccggcccatg gtgtcactgc agccccggat gctagaccgg      360

ctccgggcgc aactgcgccg ccagcccatg gagttactgc tgcgccagat gcgcggcctg      420

ccccaggtgc tacagccccc cctgcccatg gcgtaacagc tgcccccgat gctcgccctg      480

caccgggagc aacggcgcct ccagcgcacg gagtaacggc agcaccagat gctcggccag      540

caccgggggc tacagctcca cctgctcacg gtgtaactgc agcgcctgat gcacgaccag      600

cccctggagc aacagctccg cctgcacacg gagtgactgc tgcacctgat gctaggccag      660

ccccaggggc gactgcacct ccagcacacg gtgttacagc tgctccagac gcacgcccag      720

cacccggtgc cacagctcct cctgcgcatg gtgtgacagc tgcaccagac gcccgacccg      780

cgccaggagc cacggctcca ccagctcacg gcgtgaccgc ggctcctgac gctaggccag      840

ctcctggagc caccgctcct ccagctcatg gcgttacagc agctcccgac gcaagacccg      900

ctcctggggc cactgctccc cccgctcacg gggtaacagc cgctccggat gcaagacctg      960

cccctggtgc tactgcacca cccgcccatg gggttactgc agctccggac gctagacctg     1020

ctccgggagc tacagcgccc ccagcccacg gagtcacagc agcacctgac gcgagaccag     1080

cgccaggtgc aactgcccct cctgcacatg gtgttactgc cgcaccggat gccagacctg     1140

cacccggagc tacggccccg ccggctcatg gggtaactgc tgctcctgat gcccgacccg     1200

ctccaggcgc gaccgcacct cctgctcatg gagtaacagc ggcacccgat gcacggccgg     1260

ctcccggcgc tacagcacct ccggcacatg gcgtcaccgc agctccagat gccaggcccg     1320

caccaggtgc gacggcaccg cccgctcatg gtgtaaccgc tgctcccgat gcgagacctg     1380

cgcctggtgc aacagcaccc ccggctcacg gagttacggc tgctgcctca gg             1432


<210>  55
<211>  652
<212>  DNA
<213>  artificial sequence

<220>
<223>  Recounted mucin consensus

<400>  55
tgtacatgga catggtcgct gtgagtatga ccagcagcgt actctccagc cacagccccg       60

gttcaggctc ctccaccact cagggacagg atgtcactct ggccccggcc acggaaccag      120

cttcaggttc agctgccacc tggggacagg atgtcacctc ggtcaaggaa cctgcaccta      180

caaccccgaa ggagcccgca ccgaccaccc caaaagaacc tgcgccgaca actccaaagg      240

agccagctcc aacgacgcca aaggaaccag cacctacgac ccccaaggaa cccgccccga      300

cgactccgaa ggagcctgca ccaacaactc ctaaagaacc agcgcctact acgcctaaag      360

aacctgctcc tactacacca aaagagccag cacccacgac accgaaagaa cctgccccta      420

ctacccctaa agaacccgct cctaccacac caaaggaacc ggctcccact actcccaaag      480

aaccagcccc aactacacct aaagaaccgg cccccaccac tcctaaagag ccggcgccaa      540

ctactccaaa agaaccagct cctacaactc ccaaggagcc ggcacctact actccgaaag      600

agcccgcgcc cacaacaccc aaagagcctg ctccgactac tcctgcctca gg              652


<210>  56
<211>  1012
<212>  DNA
<213>  artificial sequence

<220>
<223>  Recombinant lubricin sequence

<400>  56
tgtacatgga catggtcgct gtgagtatga ccagcagcgt actctccagc cacagccccg       60

gttcaggctc ctccaccact cagggacagg atgtcactct ggccccggcc acggaaccag      120

cttcaggttc agctgccacc tggggacagg atgtcacctc ggtcgatgca gctactccag      180

ctccggacgc cgcaacaccc gctccagacg ccgccacccc agctccagat gctgctacac      240

ctgcacctga tgccgcaact cccgcgccgg atgccgcgac tccagcaccg gacgctgcga      300

cgccagcccc tgatgctgca acaccggctc ctgatgctgc gactcctgcg ccagatgcag      360

ctacaccagc cccggatgct gcaacgcctg ctcctgacgc agctactccg gcccccgacg      420

ctgctacccc ggcgcctgat gctgctactc ccgctcctga tgcggccact ccagccccag      480

acgcagcaac cccagccccc gatgctgcta cgcctgcacc cgacgcggcc acacctgcgc      540

cggacgcagc gacacctgcc cctgacgctg ccacgcccgc acctgatgca gctacgccag      600

ctcccgatgc ggcaacacct gctccagatg ccgccactcc tgctccggat gcggcgacac      660

cagcgcctga cgccgctacg ccggcacctg atgctgccac tccggctcca gatgcagcga      720

ccccagcgcc agacgcggca actccagcgc ccgatgcagc taccccagca ccagatgctg      780

caacccctgc accggatgca gcaacgccag cacctgacgc ggctactcct gcaccagatg      840

cagcaactcc tgccccggac gcggcgactc ccgcaccaga cgctgcaact ccggcaccag      900

atgcggctac ccccgctccc gacgcagcca ctcccgcccc agatgcagcc acaccagctc      960

ctgatgcagc aacaccagca cccgatgccg ctacccctgc tcccgcctca gg             1012


<210>  57
<211>  1852
<212>  DNA
<213>  artificial sequence

<220>
<223>  Recombinant lubricin sequence

<400>  57
tgtacatgga catggtcgct gtgagtatga ccagcagcgt actctccagc cacagccccg       60

gttcaggctc ctccaccact cagggacagg atgtcactct ggccccggcc acggaaccag      120

cttcaggttc agctgccacc tggggacagg atgtcacctc ggtcgatgca gctactccag      180

ctccggacgc cgcaacaccc gctccagacg ccgccacccc agctccagat gctgctacac      240

ctgcacctga tgccgcaact cccgcgccgg atgccgcgac tccagcaccg gacgctgcga      300

cgccagcccc tgatgctgca acaccggctc ctgatgctgc gactcctgcg ccagatgcag      360

ctacaccagc cccggatgct gcaacgcctg ctcctgacgc agctactccg gcccccgacg      420

ctgctacccc ggcgcctgat gctgctactc ccgctcctga tgcggccact ccagccccag      480

acgcagcaac cccagccccc gatgctgcta cgcctgcacc cgacgcggcc acacctgcgc      540

cggacgcagc gacacctgcc cctgacgctg ccacgcccgc acctgatgca gctacgccag      600

ctcccgatgc ggcaacacct gctccagatg ccgccactcc tgctccggat gcggcgacac      660

cagcgcctga cgccgctacg ccggcacctg atgctgccac tccggctcca gatgcagcga      720

ccccagcgcc agacgcggca actccagcgc ccgatgcagc taccccagca ccagatgctg      780

caacccctgc accggatgca gcaacgccag cacctgacgc ggctactcct gcaccagatg      840

cagcaactcc tgccccggac gcggcgactc ccgcaccaga cgctgcaact ccggcaccag      900

atgcggctac ccccgctccc gacgcagcca ctcccgcccc agatgcagcc acaccagctc      960

ctgatgcagc aacaccagca cccgatgccg ctacccctgc tcccgatgca gctactccag     1020

ctccggacgc cgcaacaccc gctccagacg ccgccacccc agctccagat gctgctacac     1080

ctgcacctga tgccgcaact cccgcgccgg atgccgcgac tccagcaccg gacgctgcga     1140

cgccagcccc tgatgctgca acaccggctc ctgatgctgc gactcctgcg ccagatgcag     1200

ctacaccagc cccggatgct gcaacgcctg ctcctgacgc agctactccg gcccccgacg     1260

ctgctacccc ggcgcctgat gctgctactc ccgctcctga tgcggccact ccagccccag     1320

acgcagcaac cccagccccc gatgctgcta cgcctgcacc cgacgcggcc acacctgcgc     1380

cggacgcagc gacacctgcc cctgacgctg ccacgcccgc acctgatgca gctacgccag     1440

ctcccgatgc ggcaacacct gctccagatg ccgccactcc tgctccggat gcggcgacac     1500

cagcgcctga cgccgctacg ccggcacctg atgctgccac tccggctcca gatgcagcga     1560

ccccagcgcc agacgcggca actccagcgc ccgatgcagc taccccagca ccagatgctg     1620

caacccctgc accggatgca gcaacgccag cacctgacgc ggctactcct gcaccagatg     1680

cagcaactcc tgccccggac gcggcgactc ccgcaccaga cgctgcaact ccggcaccag     1740

atgcggctac ccccgctccc gacgcagcca ctcccgcccc agatgcagcc acaccagctc     1800

ctgatgcagc aacaccagca cccgatgccg ctacccctgc tcccgcctca gg             1852


<210>  58
<211>  1132
<212>  DNA
<213>  artificial sequence

<220>
<223>  Recombinant lubricin sequence

<400>  58
tgtacatgga catggtcgct gtgagtatga ccagcagcgt actctccagc cacagccccg       60

gttcaggctc ctccaccact cagggacagg atgtcactct ggccccggcc acggaaccag      120

cttcaggttc agctgccacc tggggacagg atgtcacctc ggtcgatgca gctaccccgg      180

ctccacccga tgcggcaaca ccagcccctc ccgatgcagc aacacctgct ccccccgatg      240

ctgctacccc tgctccgcct gatgctgcaa ctccagctcc gcccgatgcc gctacacctg      300

ccccccctga cgccgccacg cccgctcctc cggatgctgc aaccccagca cccccagacg      360

ccgctacccc agctccacca gatgctgcta cacccgcacc acctgatgcc gcaacaccgg      420

cgcctcctga tgctgctact ccagccccac ctgatgcagc aactcctgcg ccaccagacg      480

ctgccacacc tgcaccacca gatgcagcca caccagcacc gccagacgca gcaacgccgg      540

ctccgccaga tgcagcgaca ccagcgccac ctgacgcagc gactccagca ccaccggatg      600

cggctacccc cgctccgccg gacgcggcga ctcctgcccc tcctgacgcg gcaactccgg      660

cccctccaga tgcggcgacc ccagccccgc cggatgccgc gactccggct cccccggacg      720

ctgcaacacc cgctccacct gatgctgcca ctcccgcgcc tccagatgct gcaacgccag      780

ctccccctga tgctgcgacg cctgctcctc cagatgcagc tacaccggct cctcctgatg      840

cagctacgcc tgcaccgcct gacgctgcta cgccagcacc tcccgacgca gccactcctg      900

cacctcctga tgcggccact ccagcgcccc cggatgcagc tactcctgct ccaccggacg      960

ccgcaactcc cgcccctccg gacgcagcta ctcccgctcc cccagatgca gcaacccctg     1020

caccccccga cgcggccacc cctgccccac cagatgccgc cactccggca ccacccgacg     1080

ctgcgactcc cgcacctcca gacgcggcta caccagctcc tcccgcctca gg             1132


<210>  59
<211>  2092
<212>  DNA
<213>  artificial sequence

<220>
<223>  Recombinant lubricin sequence

<400>  59
tgtacatgga catggtcgct gtgagtatga ccagcagcgt actctccagc cacagccccg       60

gttcaggctc ctccaccact cagggacagg atgtcactct ggccccggcc acggaaccag      120

cttcaggttc agctgccacc tggggacagg atgtcacctc ggtcgatgca gctaccccgg      180

ctccacccga tgcggcaaca ccagcccctc ccgatgcagc aacacctgct ccccccgatg      240

ctgctacccc tgctccgcct gatgctgcaa ctccagctcc gcccgatgcc gctacacctg      300

ccccccctga cgccgccacg cccgctcctc cggatgctgc aaccccagca cccccagacg      360

ccgctacccc agctccacca gatgctgcta cacccgcacc acctgatgcc gcaacaccgg      420

cgcctcctga tgctgctact ccagccccac ctgatgcagc aactcctgcg ccaccagacg      480

ctgccacacc tgcaccacca gatgcagcca caccagcacc gccagacgca gcaacgccgg      540

ctccgccaga tgcagcgaca ccagcgccac ctgacgcagc gactccagca ccaccggatg      600

cggctacccc cgctccgccg gacgcggcga ctcctgcccc tcctgacgcg gcaactccgg      660

cccctccaga tgcggcgacc ccagccccgc cggatgccgc gactccggct cccccggacg      720

ctgcaacacc cgctccacct gatgctgcca ctcccgcgcc tccagatgct gcaacgccag      780

ctccccctga tgctgcgacg cctgctcctc cagatgcagc tacaccggct cctcctgatg      840

cagctacgcc tgcaccgcct gacgctgcta cgccagcacc tcccgacgca gccactcctg      900

cacctcctga tgcggccact ccagcgcccc cggatgcagc tactcctgct ccaccggacg      960

ccgcaactcc cgcccctccg gacgcagcta ctcccgctcc cccagatgca gcaacccctg     1020

caccccccga cgcggccacc cctgccccac cagatgccgc cactccggca ccacccgacg     1080

ctgcgactcc cgcacctcca gacgcggcta caccagctcc tcccgatgca gctaccccgg     1140

ctccacccga tgcggcaaca ccagcccctc ccgatgcagc aacacctgct ccccccgatg     1200

ctgctacccc tgctccgcct gatgctgcaa ctccagctcc gcccgatgcc gctacacctg     1260

ccccccctga cgccgccacg cccgctcctc cggatgctgc aaccccagca cccccagacg     1320

ccgctacccc agctccacca gatgctgcta cacccgcacc acctgatgcc gcaacaccgg     1380

cgcctcctga tgctgctact ccagccccac ctgatgcagc aactcctgcg ccaccagacg     1440

ctgccacacc tgcaccacca gatgcagcca caccagcacc gccagacgca gcaacgccgg     1500

ctccgccaga tgcagcgaca ccagcgccac ctgacgcagc gactccagca ccaccggatg     1560

cggctacccc cgctccgccg gacgcggcga ctcctgcccc tcctgacgcg gcaactccgg     1620

cccctccaga tgcggcgacc ccagccccgc cggatgccgc gactccggct cccccggacg     1680

ctgcaacacc cgctccacct gatgctgcca ctcccgcgcc tccagatgct gcaacgccag     1740

ctccccctga tgctgcgacg cctgctcctc cagatgcagc tacaccggct cctcctgatg     1800

cagctacgcc tgcaccgcct gacgctgcta cgccagcacc tcccgacgca gccactcctg     1860

cacctcctga tgcggccact ccagcgcccc cggatgcagc tactcctgct ccaccggacg     1920

ccgcaactcc cgcccctccg gacgcagcta ctcccgctcc cccagatgca gcaacccctg     1980

caccccccga cgcggccacc cctgccccac cagatgccgc cactccggca ccacccgacg     2040

ctgcgactcc cgcacctcca gacgcggcta caccagctcc tcccgcctca gg             2092


<210>  60
<211>  1252
<212>  DNA
<213>  artificial sequence

<220>
<223>  Recombinant mucin sequence

<400>  60
tgtacatgga catggtcgct gtgagtatga ccagcagcgt actctccagc cacagccccg       60

gttcaggctc ctccaccact cagggacagg atgtcactct ggccccggcc acggaaccag      120

cttcaggttc agctgccacc tggggacagg atgtcacctc ggtcccacct gcatctacca      180

gtgccccggg tccacctgcc tctactagcg ccccaggacc tccggcaagt acatcagcgc      240

caggaccccc tgcttccact agtgcacccg gtcccccggc atctacgtct gcccctggcc      300

cacctgcttc aacttcagca ccaggaccac ccgcaagcac atcagcccca ggccctcccg      360

cctctacaag cgctccgggg cctccggcct ctacctcagc tccaggccca ccagccagca      420

cttcagcccc tggtccaccc gcttcaacct cagcacccgg acctcctgcc tcaacttccg      480

ctcccggtcc accagctagt acctctgctc cgggccctcc ggcgagcacg tcagcaccgg      540

gaccacctgc gagtacaagt gcacctggcc cgcccgctag cacaagtgcc cccggtcctc      600

cagcatccac tagtgcacca gggcctccag ccagcactag tgcgccgggt ccccccgcga      660

gtacgtcagc tccgggacct ccagcttcta catctgctcc tgggccccct gcatcaacta      720

gtgcccctgg accaccggct agtacgtcag ctcctggtcc ccctgccagt actagcgctc      780

cagggccacc agcaagtacg agcgcaccag gccccccagc ctctacgagt gcaccgggtc      840

ctcctgcaag tacctccgct ccaggtcctc cggcttcaac gtccgcacct ggacctcccg      900

cgtccacatc agctcccggc cctccagcga gtacttctgc tcccggacca ccagcgtcca      960

catctgcgcc tggtcctccc gctagtacct ctgcacctgg tccgccggcc agtacaagtg     1020

ctcccgggcc tcccgcatca acatctgcac caggtccacc ggcgtctact agtgccccag     1080

gtcccccagc ttcaacatca gcacctgggc cgcctgctag tacatccgct cctggacccc     1140

cagcaagtac ttccgcccct gggcctcctg cttctacttc agctcctggc cctcctgcgt     1200

caactagtgc tccaggaccg ccagctagta cttccgcgcc cggtgcctca gg             1252


<210>  61
<211>  751
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA

<400>  61
cctcaggctc tgcatcaggc tcagctatgg tgtccaaggg cgaggagctg ttcaccgggg       60

tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc tccgtgcggg      120

gcgagggcga gggcgatgcc accaacggca agctgaccct gaagttcatc agcaccaccg      180

gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc gtgcagagct      240

tctcccgcta ccccgaccac atgaagcgcc acgacttctt caagagcgcc atgcccgaag      300

gctacgtcca ggagcgcacc atctccttca aggacgacgg cacctacaag acccgcgccg      360

aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca      420

aggaggacgg caacatcctg gggcacaagc tggagtacaa cttcaactcc cacaacgtct      480

atatcaccgc cgacaagcag aagaacggca tcaaggccaa cttcaagatc cgccacaacg      540

tggaggacgg ctccgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg      600

gccccgtgct gctgcccgac aaccactacc tgtccaccca gtccaagctg tccaaagacc      660

ccaacgagaa gcgcgatcac atggtccttc tggaattcgt gaccgccgcc gggatcactc      720

acggcatgga cgagctgtat aagggctcag c                                     751


<210>  62
<211>  678
<212>  DNA
<213>  artificial sequence

<220>
<223>  Recombinant membrane anchor cDNA

<400>  62
gctcagcttc tactctggtg cacaacggca cctctgccag ggctaccaca accccagcca       60

gcaagagcac tccattctca attcccagcc accactctga tactcctacc acccttgcca      120

gccatagcac caagactgat gccagtagca ctcaccatag ctcggtacct cctctcacct      180

cctccaatca cagcacttct ccccagttgt ctactggggt ctctttcttt ttcctgtctt      240

ttcacatttc aaacctccag tttaattcct ctctggaaga tcccagcacc gactactacc      300

aagagctgca gagagacatt tctgaaatgt ttttgcagat ttataaacaa gggggttttc      360

tgggcctctc caatattaag ttcaggccag gatctgtggt ggtacaattg actctggcct      420

tccgagaagg taccatcaat gtccacgacg tggagacaca gttcaatcag tataaaacgg      480

aagcagcctc tcgatataac ctgacgatct cagacgtcag cgtgagtgat gtgccatttc      540

ctttctctgc ccagtctggg gctggggtgc caggctgggg catcgcgctg ctggtgctgg      600

tctgtgttct ggttgcgctg gccattgtct atctcattgc cttggctgtc tgtcagtgcc      660

gccgaaagta gggaattc                                                    678


<210>  63
<211>  134
<212>  DNA
<213>  artificial sequence

<220>
<223>  Transmembrane cDNA

<400>  63
cctcaggcat actttattgg cgaaacccaa cggaaagtga tagcatcgtt ttggcaatta       60

tcgtccccag tctgctcctc ttgctctgcc tggctttgtt gtggtacatg cgccgacgaa      120

gtatgtagga attc                                                        134


<210>  64
<211>  231
<212>  DNA
<213>  artificial sequence

<220>
<223>  Cytoplasmic motif cDNA

<400>  64
tctagatgtc agtgccgccg aaagaactac gggcagctgg acatctttcc agcccgggat       60

acctaccatc ctatgagcga gtaccccacc taccacaccc atgggcgcta tgtgccccct      120

agcagtaccg atcgtagccc ctatgagaag gtttctgcag gtaatggtgg cagcagcctc      180

tcttacacaa acccagcagt ggcagccgct tctgccaact tgtaggaatt c               231


<210>  65
<211>  33
<212>  DNA
<213>  artificial sequence

<220>
<223>  Cytoplasmic motif cDNA

<400>  65
tctagatgtc agtgccgccg aaagtaggaa ttc                                    33


<210>  66
<211>  1404
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val 
1               5                   10                  15      


Phe Val Ile Gln Gln Val Ser Ser Gln Asp Leu Ser Ser Cys Ala Gly 
            20                  25                  30          


Arg Cys Gly Glu Gly Tyr Ser Arg Asp Ala Thr Cys Asn Cys Asp Tyr 
        35                  40                  45              


Asn Cys Gln His Tyr Met Glu Cys Cys Pro Asp Phe Lys Arg Val Cys 
    50                  55                  60                  


Thr Ala Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Glu Arg 
65                  70                  75                  80  


Gly Arg Glu Cys Asp Cys Asp Ala Gln Cys Lys Lys Tyr Asp Lys Cys 
                85                  90                  95      


Cys Pro Asp Tyr Glu Ser Phe Cys Ala Glu Val His Asn Pro Thr Ser 
            100                 105                 110         


Pro Pro Ser Ser Lys Lys Ala Pro Pro Pro Ser Gly Ala Ser Gln Thr 
        115                 120                 125             


Ile Lys Ser Thr Thr Lys Arg Ser Pro Lys Pro Pro Asn Lys Lys Lys 
    130                 135                 140                 


Thr Lys Lys Val Ile Glu Ser Glu Glu Ile Thr Glu Glu His Ser Val 
145                 150                 155                 160 


Ser Glu Asn Gln Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                165                 170                 175     


Ser Thr Ile Arg Lys Ile Lys Ser Ser Lys Asn Ser Ala Ala Asn Arg 
            180                 185                 190         


Glu Leu Gln Lys Lys Leu Lys Val Lys Asp Asn Lys Lys Asn Arg Thr 
        195                 200                 205             


Lys Lys Lys Pro Thr Pro Lys Pro Pro Val Val Asp Glu Ala Gly Ser 
    210                 215                 220                 


Gly Leu Asp Asn Gly Asp Phe Lys Val Thr Thr Pro Asp Thr Ser Thr 
225                 230                 235                 240 


Thr Gln His Asn Lys Val Ser Thr Ser Pro Lys Ile Thr Thr Ala Lys 
                245                 250                 255     


Pro Ile Asn Pro Arg Pro Ser Leu Pro Pro Asn Ser Asp Thr Ser Lys 
            260                 265                 270         


Glu Thr Ser Leu Thr Val Asn Lys Glu Thr Thr Val Glu Thr Lys Glu 
        275                 280                 285             


Thr Thr Thr Thr Asn Lys Gln Thr Ser Thr Asp Gly Lys Glu Lys Thr 
    290                 295                 300                 


Thr Ser Ala Lys Glu Thr Gln Ser Ile Glu Lys Thr Ser Ala Lys Asp 
305                 310                 315                 320 


Leu Ala Pro Thr Ser Lys Val Leu Ala Lys Pro Thr Pro Lys Ala Glu 
                325                 330                 335     


Thr Thr Thr Lys Gly Pro Ala Leu Thr Thr Pro Lys Glu Pro Thr Pro 
            340                 345                 350         


Thr Thr Pro Lys Glu Pro Ala Ser Thr Thr Pro Lys Glu Pro Thr Pro 
        355                 360                 365             


Thr Thr Ile Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
    370                 375                 380                 


Thr Thr Lys Ser Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
385                 390                 395                 400 


Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
                405                 410                 415     


Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser Ala Pro Thr Thr Pro 
            420                 425                 430         


Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro 
        435                 440                 445             


Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Thr Pro Thr Thr Pro 
    450                 455                 460                 


Lys Glu Pro Ala Pro Thr Thr Lys Glu Pro Ala Pro Thr Thr Pro Lys 
465                 470                 475                 480 


Glu Pro Ala Pro Thr Ala Pro Lys Lys Pro Ala Pro Thr Thr Pro Lys 
                485                 490                 495     


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys 
            500                 505                 510         


Glu Pro Ser Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Thr Lys 
        515                 520                 525             


Ser Ala Pro Thr Thr Thr Lys Glu Pro Ala Pro Thr Thr Thr Lys Ser 
    530                 535                 540                 


Ala Pro Thr Thr Pro Lys Glu Pro Ser Pro Thr Thr Thr Lys Glu Pro 
545                 550                 555                 560 


Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro 
                565                 570                 575     


Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro 
            580                 585                 590         


Ala Pro Thr Thr Thr Lys Lys Pro Ala Pro Thr Thr Pro Lys Glu Pro 
        595                 600                 605             


Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys Lys Leu 
    610                 615                 620                 


Thr Pro Thr Thr Pro Glu Lys Leu Ala Pro Thr Thr Pro Glu Lys Pro 
625                 630                 635                 640 


Ala Pro Thr Thr Pro Glu Glu Leu Ala Pro Thr Thr Pro Glu Glu Pro 
                645                 650                 655     


Thr Pro Thr Thr Pro Glu Glu Pro Ala Pro Thr Thr Pro Lys Ala Ala 
            660                 665                 670         


Ala Pro Asn Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro 
        675                 680                 685             


Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Thr 
    690                 695                 700                 


Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr Thr Leu Lys Glu Pro 
705                 710                 715                 720 


Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys Glu Leu Ala Pro Thr 
                725                 730                 735     


Thr Thr Lys Glu Pro Thr Ser Thr Thr Ser Asp Lys Pro Ala Pro Thr 
            740                 745                 750         


Thr Pro Lys Gly Thr Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
        755                 760                 765             


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Gly Thr Ala Pro Thr 
    770                 775                 780                 


Thr Leu Lys Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Lys 
785                 790                 795                 800 


Glu Leu Ala Pro Thr Thr Thr Lys Gly Pro Thr Ser Thr Thr Ser Asp 
                805                 810                 815     


Lys Pro Ala Pro Thr Thr Pro Lys Glu Thr Ala Pro Thr Thr Pro Lys 
            820                 825                 830         


Glu Pro Ala Pro Thr Thr Pro Lys Lys Pro Ala Pro Thr Thr Pro Glu 
        835                 840                 845             


Thr Pro Pro Pro Thr Thr Ser Glu Val Ser Thr Pro Thr Thr Thr Lys 
    850                 855                 860                 


Glu Pro Thr Thr Ile His Lys Ser Pro Asp Glu Ser Thr Pro Glu Leu 
865                 870                 875                 880 


Ser Ala Glu Pro Thr Pro Lys Ala Leu Glu Asn Ser Pro Lys Glu Pro 
                885                 890                 895     


Gly Val Pro Thr Thr Lys Thr Pro Ala Ala Thr Lys Pro Glu Met Thr 
            900                 905                 910         


Thr Thr Ala Lys Asp Lys Thr Thr Glu Arg Asp Leu Arg Thr Thr Pro 
        915                 920                 925             


Glu Thr Thr Thr Ala Ala Pro Lys Met Thr Lys Glu Thr Ala Thr Thr 
    930                 935                 940                 


Thr Glu Lys Thr Thr Glu Ser Lys Ile Thr Ala Thr Thr Thr Gln Val 
945                 950                 955                 960 


Thr Ser Thr Thr Thr Gln Asp Thr Thr Pro Phe Lys Ile Thr Thr Leu 
                965                 970                 975     


Lys Thr Thr Thr Leu Ala Pro Lys Val Thr Thr Thr Lys Lys Thr Ile 
            980                 985                 990         


Thr Thr Thr Glu Ile Met Asn Lys  Pro Glu Glu Thr Ala  Lys Pro Lys 
        995                 1000                 1005             


Asp Arg  Ala Thr Asn Ser Lys  Ala Thr Thr Pro Lys  Pro Gln Lys 
    1010                 1015                 1020             


Pro Thr  Lys Ala Pro Lys Lys  Pro Thr Ser Thr Lys  Lys Pro Lys 
    1025                 1030                 1035             


Thr Met  Pro Arg Val Arg Lys  Pro Lys Thr Thr Pro  Thr Pro Arg 
    1040                 1045                 1050             


Lys Met  Thr Ser Thr Met Pro  Glu Leu Asn Pro Thr  Ser Arg Ile 
    1055                 1060                 1065             


Ala Glu  Ala Met Leu Gln Thr  Thr Thr Arg Pro Asn  Gln Thr Pro 
    1070                 1075                 1080             


Asn Ser  Lys Leu Val Glu Val  Asn Pro Lys Ser Glu  Asp Ala Gly 
    1085                 1090                 1095             


Gly Ala  Glu Gly Glu Thr Pro  His Met Leu Leu Arg  Pro His Val 
    1100                 1105                 1110             


Phe Met  Pro Glu Val Thr Pro  Asp Met Asp Tyr Leu  Pro Arg Val 
    1115                 1120                 1125             


Pro Asn  Gln Gly Ile Ile Ile  Asn Pro Met Leu Ser  Asp Glu Thr 
    1130                 1135                 1140             


Asn Ile  Cys Asn Gly Lys Pro  Val Asp Gly Leu Thr  Thr Leu Arg 
    1145                 1150                 1155             


Asn Gly  Thr Leu Val Ala Phe  Arg Gly His Tyr Phe  Trp Met Leu 
    1160                 1165                 1170             


Ser Pro  Phe Ser Pro Pro Ser  Pro Ala Arg Arg Ile  Thr Glu Val 
    1175                 1180                 1185             


Trp Gly  Ile Pro Ser Pro Ile  Asp Thr Val Phe Thr  Arg Cys Asn 
    1190                 1195                 1200             


Cys Glu  Gly Lys Thr Phe Phe  Phe Lys Asp Ser Gln  Tyr Trp Arg 
    1205                 1210                 1215             


Phe Thr  Asn Asp Ile Lys Asp  Ala Gly Tyr Pro Lys  Pro Ile Phe 
    1220                 1225                 1230             


Lys Gly  Phe Gly Gly Leu Thr  Gly Gln Ile Val Ala  Ala Leu Ser 
    1235                 1240                 1245             


Thr Ala  Lys Tyr Lys Asn Trp  Pro Glu Ser Val Tyr  Phe Phe Lys 
    1250                 1255                 1260             


Arg Gly  Gly Ser Ile Gln Gln  Tyr Ile Tyr Lys Gln  Glu Pro Val 
    1265                 1270                 1275             


Gln Lys  Cys Pro Gly Arg Arg  Pro Ala Leu Asn Tyr  Pro Val Tyr 
    1280                 1285                 1290             


Gly Glu  Thr Thr Gln Val Arg  Arg Arg Arg Phe Glu  Arg Ala Ile 
    1295                 1300                 1305             


Gly Pro  Ser Gln Thr His Thr  Ile Arg Ile Gln Tyr  Ser Pro Ala 
    1310                 1315                 1320             


Arg Leu  Ala Tyr Gln Asp Lys  Gly Val Leu His Asn  Glu Val Lys 
    1325                 1330                 1335             


Val Ser  Ile Leu Trp Arg Gly  Leu Pro Asn Val Val  Thr Ser Ala 
    1340                 1345                 1350             


Ile Ser  Leu Pro Asn Ile Arg  Lys Pro Asp Gly Tyr  Asp Tyr Tyr 
    1355                 1360                 1365             


Ala Phe  Ser Lys Asp Gln Tyr  Tyr Asn Ile Asp Val  Pro Ser Arg 
    1370                 1375                 1380             


Thr Ala  Arg Ala Ile Thr Thr  Arg Ser Gly Gln Thr  Leu Ser Lys 
    1385                 1390                 1395             


Val Trp  Tyr Asn Cys Pro 
    1400                 


<210>  67
<211>  4107
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA

<400>  67
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gacggctccc aggacctgtc tagctgtgcc ggaagatgtg gcgagggcta cagcagagat      120

gccacctgta actgcgacta caactgccag cactacatgg aatgctgccc cgacttcaag      180

agagtgtgca cagccgagct gagctgcaag ggcagatgct tcgagtcctt cgagaggggc      240

agagagtgcg attgcgacgc ccagtgcaag aaatacgaca agtgctgccc tgactacgag      300

agcttctgtg ccgaggtgca caaccccaca tctccaccta gcagcaagaa ggcccctcca      360

ccttctggcg cctctcagac aatcaagagc accaccaagc ggagccccaa gcctcctaac      420

aagaaaaaga ccaagaaagt gatcgagagc gaggaaatca ccgaggaaca cagcgtgtcc      480

gagaatcaag agagcagctc cagcagcagc tcctccagct ctagctccac catccggaag      540

atcaagtcca gcaagaacag cgccgccaac agagagctgc agaaaaagct gaaagtgaag      600

gacaacaaga agaaccggac caagaagaag cccacaccta agcctccagt ggtggatgag      660

gctggcagcg gactggacaa cggcgacttc aaagtgacca cacctgacac cagcaccaca      720

cagcacaaca aggtgtccac ctctcctaag atcaccaccg ccaagcctat caaccccaga      780

cctagcctgc ctccaaacag cgacacctcc aaagaaacca gcctgaccgt gaacaaagag      840

acaaccgtcg agacaaaaga gactaccacc accaacaagc agactagtac cgacggcaaa      900

gagaaaacca ccagcgccaa agagactcag agcatcgaaa agacctccgc caaggatctg      960

gcccctacct ctaaggtgct ggccaagcca acaccaaagg ccgagacaac cacaaagggc     1020

cctgctctga caacccctaa ggagccagca cccacaacgc cgaaggaacc agcgcccacg     1080

acccctaaag aaccagctcc tacaacgccc aaggaaccgg cgccaacaac gcctaaggaa     1140

ccggcaccaa caacacccaa agagcccgcc cccactactc ctaaagaacc ggctccaact     1200

acaccgaagg aacctgcccc gacaacccca aaggaaccag cccctacaac ccctaaagag     1260

ccagcgccaa ccacgcccaa agaacctgcg ccgactaccc cgaaagagcc ggcacccact     1320

acgcccaaag agccggcccc cacaaccccg aaggaaccgg ctccgacgac accaaaggag     1380

cctgcgccca ctacacccaa ggagcctgca ccaaccactc ccaaggagcc agctcccaca     1440

acaccaaagg aacccgcgcc caccacgcca aaagagccag cacctacaac acctaaggaa     1500

cctgctccaa ccaccccaaa ggagcccgca cctacgactc ccaaggaacc cgctccaacg     1560

acgcctaagg agccggcacc taccactcca aaggagccag ccccgactac tccgaaggag     1620

cctgccccaa ctactcccaa agagccagcc cccacgactc ctaaggaacc agcaccaacg     1680

acaccgaaag aacccgctcc cacgacgccg aaagaacctg cccctacgac acccaaagaa     1740

ccagccccaa caactcctaa agagccggct cccactaccc ctaaggagcc agcgcctacg     1800

accccaaaag agcctgcacc gacaacgcca aaggaacctg cacccaccac ccctaaggaa     1860

cccgcaccaa ctaccccaaa agaacctgca cctactactc caaaggaacc ggcccctacc     1920

acccccaagg aacctgcgcc aactacgccg aaagagcccg cgccaacgac tccgaaagaa     1980

ccagcgccga caactccaaa agagcccgct ccgaccacac cgaaagagcc tgctcccacc     2040

acaccaaaag aaccagcacc gaccactcct aaggagcctg ctcctactac gcctaaagaa     2100

cctgctccga ctacacctaa agaacccgcg cctaccacgc ctaaagagcc tgcgcctaca     2160

actcccaaag aacccgcacc gactacgcca aaagaaccgg ccccaacgac cccgaaagaa     2220

ccggcaccga cgactccaaa agaacccgcc ccaaccacac ctaaagagcc cgcacccacg     2280

acacctaagg agcccgctcc taccacaccc aaggaaccag ctccaacaac ccccaaagag     2340

cctgccccca ccactccgaa ggaacccgcc cctactacac caaaagagcc ggcgcctact     2400

acccccaaag aaccggcgcc cacaactccg aaagagccag ctccgacaac accgagcgaa     2460

gtgtctaccc ctacaaccac caaagagcca accaccatcc acaagagccc cgacgagtct     2520

acacctgagc tgtctgccga gcctactcct aaggctctgg aaaacagccc caaagaaccc     2580

ggggtgccca ccacaaaaac accagccgcc acaaagcccg agatgaccac cacagccaag     2640

gacaagacca ccgagcggga cctgagaaca acccctgaaa ccacaaccgc cgctccaaag     2700

atgacaaaag aaaccgccac aaccaccgag aaaacaaccg agagcaagat caccgccacc     2760

acaacacaag tgacctccac caccactcag gacaccacac ctttcaagat cacaaccctc     2820

aagaccacta cactggcccc aaaagtgacg accacaaaga aaaccatcac cacgaccgag     2880

atcatgaaca agcccgagga aaccgctaag cccaaggaca gggccaccaa cagcaaggcc     2940

accacaccaa agccacagaa gcctacaaag gcccctaaga agccaaccag cacaaaaaag     3000

cccaagacca tgcctagagt gcggaagcct aagacaaccc caacacctcg gaagatgacc     3060

agcactatgc ccgagctgaa ccccacctct agaatcgccg aagccatgct gcagaccacc     3120

actagaccca atcagacccc taacagcaag ctggtggaag tgaaccccaa gtccgaagat     3180

gccggcggag ctgaaggcga gacacctcat atgctgctga ggccccacgt gttcatgccc     3240

gaagtgaccc ctgacatgga ctacctgcca agagtgccca accagggcat catcatcaac     3300

cctatgctga gcgacgagac aaacatctgc aacggcaagc ccgtggacgg cctgaccaca     3360

ctgagaaatg gaaccctggt ggctttccgg ggccactact tttggatgct gagccctttc     3420

agccctccat ctcctgccag acggatcaca gaagtgtggg gcatcccttc tccaatcgac     3480

accgtgttca cccggtgcaa ctgcgagggc aagacattct tcttcaagga cagccagtat     3540

tggcggttca ccaacgacat caaggacgcc ggctatccca agccaatctt caaaggcttc     3600

ggaggcctga ccggccagat tgtggctgct ctgtctaccg ccaagtacaa gaactggccc     3660

gagagcgtgt acttctttaa gagaggcggc tccatccagc agtacatcta caagcaagag     3720

cccgtgcaga agtgccccgg aagaaggcca gctctgaatt accccgtgta cggcgagact     3780

acccaagtgc ggagaagaag attcgagaga gccatcggac ccagccagac acacaccatc     3840

agaatccagt acagccccgc cagactggcc taccaggata agggcgtgct gcacaacgaa     3900

gtgaaagtgt ccatcctgtg gcggggactg cccaatgtgg tcacaagcgc catcagcctg     3960

cctaacatca gaaagcccga cggctacgac tactacgcct ttagcaagga ccagtactac     4020

aacatcgacg tgcccagcag aaccgccaga gccatcacaa caagatccgg ccagacactg     4080

agcaaagtgt ggtacaactg tccttga                                         4107


<210>  68
<211>  1368
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant protein

<400>  68

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ser Gln Asp Leu Ser Ser Cys Ala Gly Arg 
            20                  25                  30          


Cys Gly Glu Gly Tyr Ser Arg Asp Ala Thr Cys Asn Cys Asp Tyr Asn 
        35                  40                  45              


Cys Gln His Tyr Met Glu Cys Cys Pro Asp Phe Lys Arg Val Cys Thr 
    50                  55                  60                  


Ala Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Glu Arg Gly 
65                  70                  75                  80  


Arg Glu Cys Asp Cys Asp Ala Gln Cys Lys Lys Tyr Asp Lys Cys Cys 
                85                  90                  95      


Pro Asp Tyr Glu Ser Phe Cys Ala Glu Val His Asn Pro Thr Ser Pro 
            100                 105                 110         


Pro Ser Ser Lys Lys Ala Pro Pro Pro Ser Gly Ala Ser Gln Thr Ile 
        115                 120                 125             


Lys Ser Thr Thr Lys Arg Ser Pro Lys Pro Pro Asn Lys Lys Lys Thr 
    130                 135                 140                 


Lys Lys Val Ile Glu Ser Glu Glu Ile Thr Glu Glu His Ser Val Ser 
145                 150                 155                 160 


Glu Asn Gln Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                165                 170                 175     


Thr Ile Arg Lys Ile Lys Ser Ser Lys Asn Ser Ala Ala Asn Arg Glu 
            180                 185                 190         


Leu Gln Lys Lys Leu Lys Val Lys Asp Asn Lys Lys Asn Arg Thr Lys 
        195                 200                 205             


Lys Lys Pro Thr Pro Lys Pro Pro Val Val Asp Glu Ala Gly Ser Gly 
    210                 215                 220                 


Leu Asp Asn Gly Asp Phe Lys Val Thr Thr Pro Asp Thr Ser Thr Thr 
225                 230                 235                 240 


Gln His Asn Lys Val Ser Thr Ser Pro Lys Ile Thr Thr Ala Lys Pro 
                245                 250                 255     


Ile Asn Pro Arg Pro Ser Leu Pro Pro Asn Ser Asp Thr Ser Lys Glu 
            260                 265                 270         


Thr Ser Leu Thr Val Asn Lys Glu Thr Thr Val Glu Thr Lys Glu Thr 
        275                 280                 285             


Thr Thr Thr Asn Lys Gln Thr Ser Thr Asp Gly Lys Glu Lys Thr Thr 
    290                 295                 300                 


Ser Ala Lys Glu Thr Gln Ser Ile Glu Lys Thr Ser Ala Lys Asp Leu 
305                 310                 315                 320 


Ala Pro Thr Ser Lys Val Leu Ala Lys Pro Thr Pro Lys Ala Glu Thr 
                325                 330                 335     


Thr Thr Lys Gly Pro Ala Leu Thr Thr Pro Lys Glu Pro Ala Pro Thr 
            340                 345                 350         


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
        355                 360                 365             


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
    370                 375                 380                 


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
385                 390                 395                 400 


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
                405                 410                 415     


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
            420                 425                 430         


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
        435                 440                 445             


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
    450                 455                 460                 


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
465                 470                 475                 480 


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
                485                 490                 495     


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
            500                 505                 510         


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
        515                 520                 525             


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
    530                 535                 540                 


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
545                 550                 555                 560 


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
                565                 570                 575     


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
            580                 585                 590         


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
        595                 600                 605             


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
    610                 615                 620                 


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
625                 630                 635                 640 


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
                645                 650                 655     


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
            660                 665                 670         


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
        675                 680                 685             


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
    690                 695                 700                 


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
705                 710                 715                 720 


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
                725                 730                 735     


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
            740                 745                 750         


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
        755                 760                 765             


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
    770                 775                 780                 


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
785                 790                 795                 800 


Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr 
                805                 810                 815     


Thr Pro Ser Glu Val Ser Thr Pro Thr Thr Thr Lys Glu Pro Thr Thr 
            820                 825                 830         


Ile His Lys Ser Pro Asp Glu Ser Thr Pro Glu Leu Ser Ala Glu Pro 
        835                 840                 845             


Thr Pro Lys Ala Leu Glu Asn Ser Pro Lys Glu Pro Gly Val Pro Thr 
    850                 855                 860                 


Thr Lys Thr Pro Ala Ala Thr Lys Pro Glu Met Thr Thr Thr Ala Lys 
865                 870                 875                 880 


Asp Lys Thr Thr Glu Arg Asp Leu Arg Thr Thr Pro Glu Thr Thr Thr 
                885                 890                 895     


Ala Ala Pro Lys Met Thr Lys Glu Thr Ala Thr Thr Thr Glu Lys Thr 
            900                 905                 910         


Thr Glu Ser Lys Ile Thr Ala Thr Thr Thr Gln Val Thr Ser Thr Thr 
        915                 920                 925             


Thr Gln Asp Thr Thr Pro Phe Lys Ile Thr Thr Leu Lys Thr Thr Thr 
    930                 935                 940                 


Leu Ala Pro Lys Val Thr Thr Thr Lys Lys Thr Ile Thr Thr Thr Glu 
945                 950                 955                 960 


Ile Met Asn Lys Pro Glu Glu Thr Ala Lys Pro Lys Asp Arg Ala Thr 
                965                 970                 975     


Asn Ser Lys Ala Thr Thr Pro Lys Pro Gln Lys Pro Thr Lys Ala Pro 
            980                 985                 990         


Lys Lys Pro Thr Ser Thr Lys Lys  Pro Lys Thr Met Pro  Arg Val Arg 
        995                 1000                 1005             


Lys Pro  Lys Thr Thr Pro Thr  Pro Arg Lys Met Thr  Ser Thr Met 
    1010                 1015                 1020             


Pro Glu  Leu Asn Pro Thr Ser  Arg Ile Ala Glu Ala  Met Leu Gln 
    1025                 1030                 1035             


Thr Thr  Thr Arg Pro Asn Gln  Thr Pro Asn Ser Lys  Leu Val Glu 
    1040                 1045                 1050             


Val Asn  Pro Lys Ser Glu Asp  Ala Gly Gly Ala Glu  Gly Glu Thr 
    1055                 1060                 1065             


Pro His  Met Leu Leu Arg Pro  His Val Phe Met Pro  Glu Val Thr 
    1070                 1075                 1080             


Pro Asp  Met Asp Tyr Leu Pro  Arg Val Pro Asn Gln  Gly Ile Ile 
    1085                 1090                 1095             


Ile Asn  Pro Met Leu Ser Asp  Glu Thr Asn Ile Cys  Asn Gly Lys 
    1100                 1105                 1110             


Pro Val  Asp Gly Leu Thr Thr  Leu Arg Asn Gly Thr  Leu Val Ala 
    1115                 1120                 1125             


Phe Arg  Gly His Tyr Phe Trp  Met Leu Ser Pro Phe  Ser Pro Pro 
    1130                 1135                 1140             


Ser Pro  Ala Arg Arg Ile Thr  Glu Val Trp Gly Ile  Pro Ser Pro 
    1145                 1150                 1155             


Ile Asp  Thr Val Phe Thr Arg  Cys Asn Cys Glu Gly  Lys Thr Phe 
    1160                 1165                 1170             


Phe Phe  Lys Asp Ser Gln Tyr  Trp Arg Phe Thr Asn  Asp Ile Lys 
    1175                 1180                 1185             


Asp Ala  Gly Tyr Pro Lys Pro  Ile Phe Lys Gly Phe  Gly Gly Leu 
    1190                 1195                 1200             


Thr Gly  Gln Ile Val Ala Ala  Leu Ser Thr Ala Lys  Tyr Lys Asn 
    1205                 1210                 1215             


Trp Pro  Glu Ser Val Tyr Phe  Phe Lys Arg Gly Gly  Ser Ile Gln 
    1220                 1225                 1230             


Gln Tyr  Ile Tyr Lys Gln Glu  Pro Val Gln Lys Cys  Pro Gly Arg 
    1235                 1240                 1245             


Arg Pro  Ala Leu Asn Tyr Pro  Val Tyr Gly Glu Thr  Thr Gln Val 
    1250                 1255                 1260             


Arg Arg  Arg Arg Phe Glu Arg  Ala Ile Gly Pro Ser  Gln Thr His 
    1265                 1270                 1275             


Thr Ile  Arg Ile Gln Tyr Ser  Pro Ala Arg Leu Ala  Tyr Gln Asp 
    1280                 1285                 1290             


Lys Gly  Val Leu His Asn Glu  Val Lys Val Ser Ile  Leu Trp Arg 
    1295                 1300                 1305             


Gly Leu  Pro Asn Val Val Thr  Ser Ala Ile Ser Leu  Pro Asn Ile 
    1310                 1315                 1320             


Arg Lys  Pro Asp Gly Tyr Asp  Tyr Tyr Ala Phe Ser  Lys Asp Gln 
    1325                 1330                 1335             


Tyr Tyr  Asn Ile Asp Val Pro  Ser Arg Thr Ala Arg  Ala Ile Thr 
    1340                 1345                 1350             


Thr Arg  Ser Gly Gln Thr Leu  Ser Lys Val Trp Tyr  Asn Cys Pro 
    1355                 1360                 1365             


<210>  69
<211>  3921
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA

<400>  69
atgcaatgga agattctccc catatacttg ttgctgctca gtgtattcct catccaacaa       60

gtaagtagtc aagatctccc ttcttgtgca ggcaggtgtg gagaaggcta tagtcgggat      120

gcgatttgta attgtgatta taactgccaa cattacatgg agtgctgtcc ggactttaag      180

aaagcatgta cggtcgagct cagttgtaaa gggcgctgtt tcgaatcttt cgctagaggc      240

cgagaatgtg actgcgacag tgactgcaaa aagtacggaa agtgttgccc agattacgag      300

gacttttgcg ggagagtaca caaccctact tcaccacctt cttccaaaac tgcaccacct      360

tccccggggg cctctcagac aattaagtca acggccaaac gctcacccaa ggctccgaac      420

aaaaaaaaga ctaagaaggt aatagagagt gaggaaatca ccgaggagca ctctgtgtca      480

gaaaaccaag aaagttcttc atcatcaagc tcttcttcat ccactattcg caaaataaag      540

tcatctaaga actctgcggc gaataaagag cttaaaaaga agccaaaagt aaaggataat      600

aaaaaggagc gaacaccgaa gaaaaagcca ccacctgaac cccccgtagt tgatgaggcg      660

gggtcaggct tggacaatgg agacattaaa ttgacaccca cgcctgacat tcctacgact      720

caacgaaata aggttactac aagtcccaaa ttcaccacag gtaagcccat caacccaaaa      780

cctagtctcc caccgaacac cgatacgtca aaggagacgt catccactcc caacaaggaa      840

acaactgtca aaagtaaaga gacacttgct aacaaggaaa ccagcagtaa agcgaaggag      900

aaaattacgt ctgctaaaga gactcggtct gcggagaaga ccccagcgaa ggactttgtg      960

cctacgacga aagcccctgt caaatctact ccgaaggcgg aaagcactac taagggccct     1020

gctctgacaa cccctaagga gccagcaccc acaacgccga aggaaccagc gcccacgacc     1080

cctaaagaac cagctcctac aacgcccaag gaaccggcgc caacaacgcc taaggaaccg     1140

gcaccaacaa cacccaaaga gcccgccccc actactccta aagaaccggc tccaactaca     1200

ccgaaggaac ctgccccgac aaccccaaag gaaccagccc ctacaacccc taaagagcca     1260

gcgccaacca cgcccaaaga acctgcgccg actaccccga aagagccggc acccactacg     1320

cccaaagagc cggcccccac aaccccgaag gaaccggctc cgacgacacc aaaggagcct     1380

gcgcccacta cacccaagga gcctgcacca accactccca aggagccagc tcccacaaca     1440

ccaaaggaac ccgcgcccac cacgccaaaa gagccagcac ctacaacacc taaggaacct     1500

gctccaacca ccccaaagga gcccgcacct acgactccca aggaacccgc tccaacgacg     1560

cctaaggagc cggcacctac cactccaaag gagccagccc cgactactcc gaaggagcct     1620

gccccaacta ctcccaaaga gccagccccc acgactccta aggaaccagc accaacgaca     1680

ccgaaagaac ccgctcccac gacgccgaaa gaacctgccc ctacgacacc caaagaacca     1740

gccccaacaa ctcctaaaga gccggctccc actaccccta aggagccagc gcctacgacc     1800

ccaaaagagc ctgcaccgac aacgccaaag gaacctgcac ccaccacccc taaggaaccc     1860

gcaccaacta ccccaaaaga acctgcacct actactccaa aggaaccggc ccctaccacc     1920

cccaaggaac ctgcgccaac tacgccgaaa gagcccgcgc caacgactcc gaaagaacca     1980

gcgccgacaa ctccaaaaga gcccgctccg accacaccga aagagcctgc tcccaccaca     2040

ccaaaagaac cagcaccgac cactcctaag gagcctgctc ctactacgcc taaagaacct     2100

gctccgacta cacctaaaga acccgcgcct accacgccta aagagcctgc gcctacaact     2160

cccaaagaac ccgcaccgac tacgccaaaa gaaccggccc caacgacccc gaaagaaccg     2220

gcaccgacga ctccaaaaga acccgcccca accacaccta aagagcccgc acccacgaca     2280

cctaaggagc ccgctcctac cacacccaag gaaccagctc caacaacccc caaagagcct     2340

gcccccacca ctccgaagga acccgcccct actacaccaa aagagccggc gcctactacc     2400

cccaaagaac cggcgcccac aactccgaaa gagccagctc cgacaacacc gagcgaagtg     2460

acaacgacgg ctaaagataa aacgaccgag aaagacataa ttccagagat taccactgct     2520

gttcccaaga tcacaactca agaaactgct acgccaaccg aggagacgac tacggaatct     2580

aagacctcaa ctacgaccca agtcacttct actactagta gcaaaaacac tccaaaagcc     2640

acgaccctcg cgcccaaggt gatgacagca acacaaaaaa ccacgactac tgaagagacc     2700

atgaacaagc ccgaagagac gacggcagtg cctaaagata ctgcaacatc aacgaaggta     2760

agcaccccgc gaccccgaaa gccaaccaaa gcaccaaaga aacccgcaag tacaaagaaa     2820

cccaacacga tccctaaacg aaaaaaacca aaaactacac ctaccccgcc aaagatgact     2880

acgagcacta tgcctaaact ccatcctacc tcctccgttg aggcaatgct gcaaactaca     2940

acgtccccca atcaacgacc taattctgag atagtagagg tcaaccccaa cgaggatacg     3000

gacgcggctg gaaagaaacc ccatatgttc ccgcgacctc ctgttttgac ccccatattt     3060

atccctggaa ccgacattct tgtgcggggg tccaatcaag atattgccat aaatcccatg     3120

ctttccgacg agacaaatct ctgtaatgga aaacctgtcg acggattgac aaccctccga     3180

aatggtacta tggtggcgtt ccgcggccat tatttctgga tgttgagtcc ttccaaaccc     3240

ccgagtcctc cccggaagat tacagaggtt tggggcatcc cctctcccat agataccgtt     3300

tttacgcgat gcaattgtga gggtaaaaca ttcttcttca agggcagtca gtactggcga     3360

ttcactaacg acatcaagga cgcaggctac cccaaacaga tcgtcaaggg tttcggaggc     3420

ttgaatggtc gaattgtcgc tgccctgtct atagctaagt acaaggaccg gccagagtct     3480

gtctattttt tcaagcgcgg cggctcagtg caacaatata cttacaagca agagccgata     3540

aaaaaatgta cagggcgccg gccggcgatt aactaccctg tatatggtga gactacacaa     3600

gtgaggcgga gacgctttga gagggcgata ggcccttctc agacgcatac catccggata     3660

cactactccc ctattcgggt tagctaccag gacaagggtt tcttgcacaa tgaagtaaaa     3720

atgtccagtc aatggagagg tttcccgaac gttgttacct cagcaattgc gctgcctaac     3780

atcaggaagc ctgatggtta cgactattac gcgttttctc gcaatcaata ttataacatt     3840

gatgttccct cccgcactgc cagagttgtg actacaagat ttggacgaac cctctccaat     3900

atatggtaca attgccccta g                                               3921


<210>  70
<211>  1306
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant protein

<400>  70

Met Gln Trp Lys Ile Leu Pro Ile Tyr Leu Leu Leu Leu Ser Val Phe 
1               5                   10                  15      


Leu Ile Gln Gln Val Ser Ser Gln Asp Leu Pro Ser Cys Ala Gly Arg 
            20                  25                  30          


Cys Gly Glu Gly Tyr Ser Arg Asp Ala Ile Cys Asn Cys Asp Tyr Asn 
        35                  40                  45              


Cys Gln His Tyr Met Glu Cys Cys Pro Asp Phe Lys Lys Ala Cys Thr 
    50                  55                  60                  


Val Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Ala Arg Gly 
65                  70                  75                  80  


Arg Glu Cys Asp Cys Asp Ser Asp Cys Lys Lys Tyr Gly Lys Cys Cys 
                85                  90                  95      


Pro Asp Tyr Glu Asp Phe Cys Gly Arg Val His Asn Pro Thr Ser Pro 
            100                 105                 110         


Pro Ser Ser Lys Thr Ala Pro Pro Ser Pro Gly Ala Ser Gln Thr Ile 
        115                 120                 125             


Lys Ser Thr Ala Lys Arg Ser Pro Lys Ala Pro Asn Lys Lys Lys Thr 
    130                 135                 140                 


Lys Lys Val Ile Glu Ser Glu Glu Ile Thr Glu Glu His Ser Val Ser 
145                 150                 155                 160 


Glu Asn Gln Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Ile 
                165                 170                 175     


Arg Lys Ile Lys Ser Ser Lys Asn Ser Ala Ala Asn Lys Glu Leu Lys 
            180                 185                 190         


Lys Lys Pro Lys Val Lys Asp Asn Lys Lys Glu Arg Thr Pro Lys Lys 
        195                 200                 205             


Lys Pro Pro Pro Glu Pro Pro Val Val Asp Glu Ala Gly Ser Gly Leu 
    210                 215                 220                 


Asp Asn Gly Asp Ile Lys Leu Thr Pro Thr Pro Asp Ile Pro Thr Thr 
225                 230                 235                 240 


Gln Arg Asn Lys Val Thr Thr Ser Pro Lys Phe Thr Thr Gly Lys Pro 
                245                 250                 255     


Ile Asn Pro Lys Pro Ser Leu Pro Pro Asn Thr Asp Thr Ser Lys Glu 
            260                 265                 270         


Thr Ser Ser Thr Pro Asn Lys Glu Thr Thr Val Lys Ser Lys Glu Thr 
        275                 280                 285             


Leu Ala Asn Lys Glu Thr Ser Ser Lys Ala Lys Glu Lys Ile Thr Ser 
    290                 295                 300                 


Ala Lys Glu Thr Arg Ser Ala Glu Lys Thr Pro Ala Lys Asp Phe Val 
305                 310                 315                 320 


Pro Thr Thr Lys Ala Pro Val Lys Ser Thr Pro Lys Ala Glu Ser Thr 
                325                 330                 335     


Thr Lys Gly Pro Ala Leu Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
            340                 345                 350         


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
        355                 360                 365             


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
    370                 375                 380                 


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
385                 390                 395                 400 


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
                405                 410                 415     


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
            420                 425                 430         


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
        435                 440                 445             


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
    450                 455                 460                 


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
465                 470                 475                 480 


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
                485                 490                 495     


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
            500                 505                 510         


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
        515                 520                 525             


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
    530                 535                 540                 


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
545                 550                 555                 560 


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
                565                 570                 575     


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
            580                 585                 590         


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
        595                 600                 605             


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
    610                 615                 620                 


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
625                 630                 635                 640 


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
                645                 650                 655     


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
            660                 665                 670         


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
        675                 680                 685             


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
    690                 695                 700                 


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
705                 710                 715                 720 


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
                725                 730                 735     


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
            740                 745                 750         


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
        755                 760                 765             


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
    770                 775                 780                 


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
785                 790                 795                 800 


Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr 
                805                 810                 815     


Pro Ser Glu Val Thr Thr Thr Ala Lys Asp Lys Thr Thr Glu Lys Asp 
            820                 825                 830         


Ile Ile Pro Glu Ile Thr Thr Ala Val Pro Lys Ile Thr Thr Gln Glu 
        835                 840                 845             


Thr Ala Thr Pro Thr Glu Glu Thr Thr Thr Glu Ser Lys Thr Ser Thr 
    850                 855                 860                 


Thr Thr Gln Val Thr Ser Thr Thr Ser Ser Lys Asn Thr Pro Lys Ala 
865                 870                 875                 880 


Thr Thr Leu Ala Pro Lys Val Met Thr Ala Thr Gln Lys Thr Thr Thr 
                885                 890                 895     


Thr Glu Glu Thr Met Asn Lys Pro Glu Glu Thr Thr Ala Val Pro Lys 
            900                 905                 910         


Asp Thr Ala Thr Ser Thr Lys Val Ser Thr Pro Arg Pro Arg Lys Pro 
        915                 920                 925             


Thr Lys Ala Pro Lys Lys Pro Ala Ser Thr Lys Lys Pro Asn Thr Ile 
    930                 935                 940                 


Pro Lys Arg Lys Lys Pro Lys Thr Thr Pro Thr Pro Pro Lys Met Thr 
945                 950                 955                 960 


Thr Ser Thr Met Pro Lys Leu His Pro Thr Ser Ser Val Glu Ala Met 
                965                 970                 975     


Leu Gln Thr Thr Thr Ser Pro Asn Gln Arg Pro Asn Ser Glu Ile Val 
            980                 985                 990         


Glu Val Asn Pro Asn Glu Asp Thr  Asp Ala Ala Gly Lys  Lys Pro His 
        995                 1000                 1005             


Met Phe  Pro Arg Pro Pro Val  Leu Thr Pro Ile Phe  Ile Pro Gly 
    1010                 1015                 1020             


Thr Asp  Ile Leu Val Arg Gly  Ser Asn Gln Asp Ile  Ala Ile Asn 
    1025                 1030                 1035             


Pro Met  Leu Ser Asp Glu Thr  Asn Leu Cys Asn Gly  Lys Pro Val 
    1040                 1045                 1050             


Asp Gly  Leu Thr Thr Leu Arg  Asn Gly Thr Met Val  Ala Phe Arg 
    1055                 1060                 1065             


Gly His  Tyr Phe Trp Met Leu  Ser Pro Ser Lys Pro  Pro Ser Pro 
    1070                 1075                 1080             


Pro Arg  Lys Ile Thr Glu Val  Trp Gly Ile Pro Ser  Pro Ile Asp 
    1085                 1090                 1095             


Thr Val  Phe Thr Arg Cys Asn  Cys Glu Gly Lys Thr  Phe Phe Phe 
    1100                 1105                 1110             


Lys Gly  Ser Gln Tyr Trp Arg  Phe Thr Asn Asp Ile  Lys Asp Ala 
    1115                 1120                 1125             


Gly Tyr  Pro Lys Gln Ile Val  Lys Gly Phe Gly Gly  Leu Asn Gly 
    1130                 1135                 1140             


Arg Ile  Val Ala Ala Leu Ser  Ile Ala Lys Tyr Lys  Asp Arg Pro 
    1145                 1150                 1155             


Glu Ser  Val Tyr Phe Phe Lys  Arg Gly Gly Ser Val  Gln Gln Tyr 
    1160                 1165                 1170             


Thr Tyr  Lys Gln Glu Pro Ile  Lys Lys Cys Thr Gly  Arg Arg Pro 
    1175                 1180                 1185             


Ala Ile  Asn Tyr Pro Val Tyr  Gly Glu Thr Thr Gln  Val Arg Arg 
    1190                 1195                 1200             


Arg Arg  Phe Glu Arg Ala Ile  Gly Pro Ser Gln Thr  His Thr Ile 
    1205                 1210                 1215             


Arg Ile  His Tyr Ser Pro Ile  Arg Val Ser Tyr Gln  Asp Lys Gly 
    1220                 1225                 1230             


Phe Leu  His Asn Glu Val Lys  Met Ser Ser Gln Trp  Arg Gly Phe 
    1235                 1240                 1245             


Pro Asn  Val Val Thr Ser Ala  Ile Ala Leu Pro Asn  Ile Arg Lys 
    1250                 1255                 1260             


Pro Asp  Gly Tyr Asp Tyr Tyr  Ala Phe Ser Arg Asn  Gln Tyr Tyr 
    1265                 1270                 1275             


Asn Ile  Asp Val Pro Ser Arg  Thr Ala Arg Val Val  Thr Thr Arg 
    1280                 1285                 1290             


Phe Gly  Arg Thr Leu Ser Asn  Ile Trp Tyr Asn Cys  Pro 
    1295                 1300                 1305     


<210>  71
<211>  4113
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA

<400>  71
atggagtgga aaatcctgcc tatttacctt ctcctgttgc tgagtatatt ctccatccag       60

gaggtttcaa gccaagacct ttctagttgc gctggtcggt gtggggaggg atactctcgg      120

gatgcgactt gcaactgcga ttttaattgt caatactaca tggaatgttg tccggacttt      180

aagaaagtct gtacatctga attgtcttgt aaaggccgct gtttcgagag tttcgaaagg      240

gggcgagaat gcgattgcga tgctgactgt aagaaatacg gtaagtgttg ttcagattat      300

gaaagcttct gcgaggaagt ccataatcct acgtctccgc cgagttccaa gacagctccc      360

ccgcctccag gggccagcca gactatcaag agtacagcta aacggtcacc aaagtcaaat      420

aagaaaaaaa ctaaaaaagt tatcgagagt gaagagatca tagaagaaca cagtgtgtcc      480

gagaatcagg agtcatcttc cagctctagc tcaagttcat ctaccatccg caaggttaag      540

tctagcaaaa actcagcagc gaacagagaa ctcaaaaaga agcctaaggt caaggattct      600

aaaaaaaaac gaaccccgaa aaaaaaaccg acgcctgagc caccagtcat agacgaggcc      660

gggagtggtt tggataacgg agacttcatg ttgattccca ccccgaaaat tccaaccacg      720

caaagaaata aggtgacgac atcaccaaag attacaacgg taaaaccaat taaccccaag      780

ccttcccttc ctcccaattc cgacacgtca aaagagacca ctagcacacc taataaagaa      840

actacggtcg agaccaagga gaccgagatc acaaacaagg agacttctac aagcgccaat      900

gaaaagacta cgagcgccag gaagagtaca gagaaaacat ccgacaaaga ttttgctccg      960

gccagcgaag tacctgcaaa aagtacccct aaggctgaaa ccaccacaaa gggccctgct     1020

ctgacaaccc ctaaggagcc agcacccaca acgccgaagg aaccagcgcc cacgacccct     1080

aaagaaccag ctcctacaac gcccaaggaa ccggcgccaa caacgcctaa ggaaccggca     1140

ccaacaacac ccaaagagcc cgcccccact actcctaaag aaccggctcc aactacaccg     1200

aaggaacctg ccccgacaac cccaaaggaa ccagccccta caacccctaa agagccagcg     1260

ccaaccacgc ccaaagaacc tgcgccgact accccgaaag agccggcacc cactacgccc     1320

aaagagccgg cccccacaac cccgaaggaa ccggctccga cgacaccaaa ggagcctgcg     1380

cccactacac ccaaggagcc tgcaccaacc actcccaagg agccagctcc cacaacacca     1440

aaggaacccg cgcccaccac gccaaaagag ccagcaccta caacacctaa ggaacctgct     1500

ccaaccaccc caaaggagcc cgcacctacg actcccaagg aacccgctcc aacgacgcct     1560

aaggagccgg cacctaccac tccaaaggag ccagccccga ctactccgaa ggagcctgcc     1620

ccaactactc ccaaagagcc agcccccacg actcctaagg aaccagcacc aacgacaccg     1680

aaagaacccg ctcccacgac gccgaaagaa cctgccccta cgacacccaa agaaccagcc     1740

ccaacaactc ctaaagagcc ggctcccact acccctaagg agccagcgcc tacgacccca     1800

aaagagcctg caccgacaac gccaaaggaa cctgcaccca ccacccctaa ggaacccgca     1860

ccaactaccc caaaagaacc tgcacctact actccaaagg aaccggcccc taccaccccc     1920

aaggaacctg cgccaactac gccgaaagag cccgcgccaa cgactccgaa agaaccagcg     1980

ccgacaactc caaaagagcc cgctccgacc acaccgaaag agcctgctcc caccacacca     2040

aaagaaccag caccgaccac tcctaaggag cctgctccta ctacgcctaa agaacctgct     2100

ccgactacac ctaaagaacc cgcgcctacc acgcctaaag agcctgcgcc tacaactccc     2160

aaagaacccg caccgactac gccaaaagaa ccggccccaa cgaccccgaa agaaccggca     2220

ccgacgactc caaaagaacc cgccccaacc acacctaaag agcccgcacc cacgacacct     2280

aaggagcccg ctcctaccac acccaaggaa ccagctccaa caacccccaa agagcctgcc     2340

cccaccactc cgaaggaacc cgcccctact acaccaaaag agccggcgcc tactaccccc     2400

aaagaaccgg cgcccacaac tccgaaagag ccagctccga caacaccgag cgaagtgtct     2460

accacgacga ctaccatgaa acctccgacg acacccaaaa atcttgctga aagcacccca     2520

gagttcccag cggagccaac acccaaagca ctggagaact cacccaaaga accggctgta     2580

ccgactacga aggcccctga agtaaccaaa ccagaagtca caacaaccgc taaagacaag     2640

gttacgggaa aggatattca cacgattccc gagataacta cagcggcacc taagataacg     2700

accgaaacgg ccacgacaac tgaagagaaa acaacggaaa gtaaggtgac ctctactata     2760

atgcaagtga cctccacgac cgaggatacg acgacaagct ccaagataac gcctaaagca     2820

acgacattgg caccgaaagt gatgaccgca acaaaaacta ccacaacaca ggaaacgata     2880

aacaagctgg aggagacgac ggctattcct aaggatacgg cgacgcacag caaagtgact     2940

acgccaaagc cgaagaagcc gaccaaagcg cctcgaaagc cgacatccac aaagaaaccg     3000

aaaacgccgc gcaagcgcaa accaaagaca acaccgattc ccccgaaaat caccaccccg     3060

accactccta aaagtaaccc tacgactttg gcggaagcca tgcttcagac tacaacttca     3120

cctaaccaga ctccaaattc cgctatgata gaggtcaacc cgaaaaacga ggacgcggac     3180

gctgcggaag gggaaaagcc gctcgtgata cttcgaccac acgtccttac tccaatcgtc     3240

ataccgggtc cggactttct tgtccgcggt ccaaacttgg gaatcggaat taaccccatg     3300

cttagcgacg agacgaactt gtgtaacggt aaaccagtgg acggactcac caccctgaga     3360

aatggaactc tcgtggcttt caggggccac tatttctgga tgctccgacc atttagtccc     3420

ccgagtccgc cgaggagaat caccgaggta tgggggattc cctctcctat tgataccgtc     3480

ttcactcgct gcaactgcga gggaaagaca tttttcttca aggactcaca gtattggcga     3540

ttcaccaacg acataaagga tgctggatac cctaaattga ttagcaaggg ctttgggggg     3600

cttagtggca aaatcgtggc cgctctttca atagcaacgt acaagaacag gccagagagc     3660

gtttattttt ttaagcgagg ggggcgaata cagcaataca tctacaagca agaacccata     3720

agaaagtgtc caggacgccg accagctata cattattcag tttacggaga ggctcctcag     3780

attcggagga gaaggttcga acgggccata ggcccgtctc agacgcacac catccgcatt     3840

cactactccc ccgtacgcgt atcataccaa gacaaagtgc cgtccactga ctttctccac     3900

aacgaggtca aagtaagcac cctgtggcgc ggacttccag acaccgttac atccgccatt     3960

tcccttccta acttgcggaa accagacgga tacgactatt atgctttttc aaaagaccaa     4020

tattataata ttgacgtccc gagccgaact gctcgcgcaa taactacccg aagtggccag     4080

acattgagta aggtctggta taactgtccc tag                                  4113


<210>  72
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Trp Lys Thr Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Val 
1               5                   10                  15      


Phe Val Ile Gln Gln Val Ser Ser 
            20                  


<210>  73
<211>  22
<212>  PRT
<213>  Canis lupus familiaris

<400>  73

Met Gln Trp Lys Ile Leu Pro Ile Tyr Leu Leu Leu Leu Ser Val Phe 
1               5                   10                  15      


Leu Ile Gln Gln Val Ser 
            20          


<210>  74
<211>  24
<212>  PRT
<213>  Equus ferus caballus

<400>  74

Met Glu Trp Lys Ile Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Ile 
1               5                   10                  15      


Phe Ser Ile Gln Glu Val Ser Ser 
            20                  


<210>  75
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  75

Gln Asp Leu Ser Ser Cys Ala Gly Arg Cys Gly Glu Gly Tyr Ser Arg 
1               5                   10                  15      


Asp Ala Thr Cys Asn Cys Asp Tyr Asn Cys Gln His Tyr Met Glu Cys 
            20                  25                  30          


Cys Pro Asp Phe Lys Arg Val Cys Thr Ala Glu Leu Ser Cys Lys Gly 
        35                  40                  45              


Arg Cys Phe Glu Ser Phe Glu Arg Gly Arg Glu Cys Asp Cys Asp Ala 
    50                  55                  60                  


Gln Cys Lys Lys Tyr Asp Lys Cys Cys Pro Asp Tyr Glu Ser Phe Cys 
65                  70                  75                  80  


Ala Glu Val His Asn Pro Thr Ser Pro Pro Ser Ser Lys Lys Ala Pro 
                85                  90                  95      


Pro Pro Ser Gly Ala Ser Gln Thr Ile Lys Ser Thr Thr Lys Arg Ser 
            100                 105                 110         


Pro Lys Pro Pro Asn Lys Lys Lys Thr Lys Lys Val Ile Glu Ser Glu 
        115                 120                 125             


Glu Ile Thr Glu Glu His Ser Val Ser Glu Asn Gln Glu Ser Ser Ser 
    130                 135                 140                 


Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Ile Arg Lys Ile Lys Ser 
145                 150                 155                 160 


Ser Lys Asn Ser Ala Ala Asn Arg Glu Leu Gln Lys Lys Leu Lys Val 
                165                 170                 175     


Lys Asp Asn Lys Lys Asn Arg Thr Lys Lys Lys Pro Thr Pro Lys Pro 
            180                 185                 190         


Pro Val Val Asp Glu Ala Gly Ser Gly Leu Asp Asn Gly Asp Phe Lys 
        195                 200                 205             


Val Thr Thr Pro Asp Thr Ser Thr Thr Gln His Asn Lys Val Ser Thr 
    210                 215                 220                 


Ser Pro Lys Ile Thr Thr Ala Lys Pro Ile Asn Pro Arg Pro Ser Leu 
225                 230                 235                 240 


Pro Pro Asn Ser Asp Thr Ser Lys Glu Thr Ser Leu Thr Val Asn Lys 
                245                 250                 255     


Glu Thr Thr Val Glu Thr Lys Glu Thr Thr Thr Thr Asn Lys Gln Thr 
            260                 265                 270         


Ser Thr Asp Gly Lys Glu Lys Thr Thr Ser Ala Lys Glu Thr Gln Ser 
        275                 280                 285             


Ile Glu Lys Thr Ser Ala Lys Asp Leu Ala Pro Thr Ser Lys Val Leu 
    290                 295                 300                 


Ala Lys Pro Thr Pro Lys Ala Glu Thr Thr Thr Lys Gly Pro Ala Leu 
305                 310                 315                 320 


Thr Thr Pro 
            


<210>  76
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  76

Ser Glu Val Ser Thr Pro Thr Thr Thr Lys Glu Pro Thr Thr Ile His 
1               5                   10                  15      


Lys Ser Pro Asp Glu Ser Thr Pro Glu Leu Ser Ala Glu Pro Thr Pro 
            20                  25                  30          


Lys Ala Leu Glu Asn Ser Pro Lys Glu Pro Gly Val Pro Thr Thr Lys 
        35                  40                  45              


Thr Pro Ala Ala Thr Lys Pro Glu Met Thr Thr Thr Ala Lys Asp Lys 
    50                  55                  60                  


Thr Thr Glu Arg Asp Leu Arg Thr Thr Pro Glu Thr Thr Thr Ala Ala 
65                  70                  75                  80  


Pro Lys Met Thr Lys Glu Thr Ala Thr Thr Thr Glu Lys Thr Thr Glu 
                85                  90                  95      


Ser Lys Ile Thr Ala Thr Thr Thr Gln Val Thr Ser Thr Thr Thr Gln 
            100                 105                 110         


Asp Thr Thr Pro Phe Lys Ile Thr Thr Leu Lys Thr Thr Thr Leu Ala 
        115                 120                 125             


Pro Lys Val Thr Thr Thr Lys Lys Thr Ile Thr Thr Thr Glu Ile Met 
    130                 135                 140                 


Asn Lys Pro Glu Glu Thr Ala Lys Pro Lys Asp Arg Ala Thr Asn Ser 
145                 150                 155                 160 


Lys Ala Thr Thr Pro Lys Pro Gln Lys Pro Thr Lys Ala Pro Lys Lys 
                165                 170                 175     


Pro Thr Ser Thr Lys Lys Pro Lys Thr Met Pro Arg Val Arg Lys Pro 
            180                 185                 190         


Lys Thr Thr Pro Thr Pro Arg Lys Met Thr Ser Thr Met Pro Glu Leu 
        195                 200                 205             


Asn Pro Thr Ser Arg Ile Ala Glu Ala Met Leu Gln Thr Thr Thr Arg 
    210                 215                 220                 


Pro Asn Gln Thr Pro Asn Ser Lys Leu Val Glu Val Asn Pro Lys Ser 
225                 230                 235                 240 


Glu Asp Ala Gly Gly Ala Glu Gly Glu Thr Pro His Met Leu Leu Arg 
                245                 250                 255     


Pro His Val Phe Met Pro Glu Val Thr Pro Asp Met Asp Tyr Leu Pro 
            260                 265                 270         


Arg Val Pro Asn Gln Gly Ile Ile Ile Asn Pro Met Leu Ser Asp Glu 
        275                 280                 285             


Thr Asn Ile Cys Asn Gly Lys Pro Val Asp Gly Leu Thr Thr Leu Arg 
    290                 295                 300                 


Asn Gly Thr Leu Val Ala Phe Arg Gly His Tyr Phe Trp Met Leu Ser 
305                 310                 315                 320 


Pro Phe Ser Pro Pro Ser Pro Ala Arg Arg Ile Thr Glu Val Trp Gly 
                325                 330                 335     


Ile Pro Ser Pro Ile Asp Thr Val Phe Thr Arg Cys Asn Cys Glu Gly 
            340                 345                 350         


Lys Thr Phe Phe Phe Lys Asp Ser Gln Tyr Trp Arg Phe Thr Asn Asp 
        355                 360                 365             


Ile Lys Asp Ala Gly Tyr Pro Lys Pro Ile Phe Lys Gly Phe Gly Gly 
    370                 375                 380                 


Leu Thr Gly Gln Ile Val Ala Ala Leu Ser Thr Ala Lys Tyr Lys Asn 
385                 390                 395                 400 


Trp Pro Glu Ser Val Tyr Phe Phe Lys Arg Gly Gly Ser Ile Gln Gln 
                405                 410                 415     


Tyr Ile Tyr Lys Gln Glu Pro Val Gln Lys Cys Pro Gly Arg Arg Pro 
            420                 425                 430         


Ala Leu Asn Tyr Pro Val Tyr Gly Glu Thr Thr Gln Val Arg Arg Arg 
        435                 440                 445             


Arg Phe Glu Arg Ala Ile Gly Pro Ser Gln Thr His Thr Ile Arg Ile 
    450                 455                 460                 


Gln Tyr Ser Pro Ala Arg Leu Ala Tyr Gln Asp Lys Gly Val Leu His 
465                 470                 475                 480 


Asn Glu Val Lys Val Ser Ile Leu Trp Arg Gly Leu Pro Asn Val Val 
                485                 490                 495     


Thr Ser Ala Ile Ser Leu Pro Asn Ile Arg Lys Pro Asp Gly Tyr Asp 
            500                 505                 510         


Tyr Tyr Ala Phe Ser Lys Asp Gln Tyr Tyr Asn Ile Asp Val Pro Ser 
        515                 520                 525             


Arg Thr Ala Arg Ala Ile Thr Thr Arg Ser Gly Gln Thr Leu Ser Lys 
    530                 535                 540                 


Val Trp Tyr Asn Cys Pro 
545                 550 


<210>  77
<211>  322
<212>  PRT
<213>  Canis lupus familiaris

<400>  77

Gln Asp Leu Pro Ser Cys Ala Gly Arg Cys Gly Glu Gly Tyr Ser Arg 
1               5                   10                  15      


Asp Ala Ile Cys Asn Cys Asp Tyr Asn Cys Gln His Tyr Met Glu Cys 
            20                  25                  30          


Cys Pro Asp Phe Lys Lys Ala Cys Thr Val Glu Leu Ser Cys Lys Gly 
        35                  40                  45              


Arg Cys Phe Glu Ser Phe Ala Arg Gly Arg Glu Cys Asp Cys Asp Ser 
    50                  55                  60                  


Asp Cys Lys Lys Tyr Gly Lys Cys Cys Pro Asp Tyr Glu Asp Phe Cys 
65                  70                  75                  80  


Gly Arg Val His Asn Pro Thr Ser Pro Pro Ser Ser Lys Thr Ala Pro 
                85                  90                  95      


Pro Ser Pro Gly Ala Ser Gln Thr Ile Lys Ser Thr Ala Lys Arg Ser 
            100                 105                 110         


Pro Lys Ala Pro Asn Lys Lys Lys Thr Lys Lys Val Ile Glu Ser Glu 
        115                 120                 125             


Glu Ile Thr Glu Glu His Ser Val Ser Glu Asn Gln Glu Ser Ser Ser 
    130                 135                 140                 


Ser Ser Ser Ser Ser Ser Ser Thr Ile Arg Lys Ile Lys Ser Ser Lys 
145                 150                 155                 160 


Asn Ser Ala Ala Asn Lys Glu Leu Lys Lys Lys Pro Lys Val Lys Asp 
                165                 170                 175     


Asn Lys Lys Glu Arg Thr Pro Lys Lys Lys Pro Pro Pro Glu Pro Pro 
            180                 185                 190         


Val Val Asp Glu Ala Gly Ser Gly Leu Asp Asn Gly Asp Ile Lys Leu 
        195                 200                 205             


Thr Pro Thr Pro Asp Ile Pro Thr Thr Gln Arg Asn Lys Val Thr Thr 
    210                 215                 220                 


Ser Pro Lys Phe Thr Thr Gly Lys Pro Ile Asn Pro Lys Pro Ser Leu 
225                 230                 235                 240 


Pro Pro Asn Thr Asp Thr Ser Lys Glu Thr Ser Ser Thr Pro Asn Lys 
                245                 250                 255     


Glu Thr Thr Val Lys Ser Lys Glu Thr Leu Ala Asn Lys Glu Thr Ser 
            260                 265                 270         


Ser Lys Ala Lys Glu Lys Ile Thr Ser Ala Lys Glu Thr Arg Ser Ala 
        275                 280                 285             


Glu Lys Thr Pro Ala Lys Asp Phe Val Pro Thr Thr Lys Ala Pro Val 
    290                 295                 300                 


Lys Ser Thr Pro Lys Ala Glu Ser Thr Thr Lys Gly Pro Ala Leu Thr 
305                 310                 315                 320 


Thr Pro 
        


<210>  78
<211>  488
<212>  PRT
<213>  Canis lupus familiaris

<400>  78

Ser Glu Val Thr Thr Thr Ala Lys Asp Lys Thr Thr Glu Lys Asp Ile 
1               5                   10                  15      


Ile Pro Glu Ile Thr Thr Ala Val Pro Lys Ile Thr Thr Gln Glu Thr 
            20                  25                  30          


Ala Thr Pro Thr Glu Glu Thr Thr Thr Glu Ser Lys Thr Ser Thr Thr 
        35                  40                  45              


Thr Gln Val Thr Ser Thr Thr Ser Ser Lys Asn Thr Pro Lys Ala Thr 
    50                  55                  60                  


Thr Leu Ala Pro Lys Val Met Thr Ala Thr Gln Lys Thr Thr Thr Thr 
65                  70                  75                  80  


Glu Glu Thr Met Asn Lys Pro Glu Glu Thr Thr Ala Val Pro Lys Asp 
                85                  90                  95      


Thr Ala Thr Ser Thr Lys Val Ser Thr Pro Arg Pro Arg Lys Pro Thr 
            100                 105                 110         


Lys Ala Pro Lys Lys Pro Ala Ser Thr Lys Lys Pro Asn Thr Ile Pro 
        115                 120                 125             


Lys Arg Lys Lys Pro Lys Thr Thr Pro Thr Pro Pro Lys Met Thr Thr 
    130                 135                 140                 


Ser Thr Met Pro Lys Leu His Pro Thr Ser Ser Val Glu Ala Met Leu 
145                 150                 155                 160 


Gln Thr Thr Thr Ser Pro Asn Gln Arg Pro Asn Ser Glu Ile Val Glu 
                165                 170                 175     


Val Asn Pro Asn Glu Asp Thr Asp Ala Ala Gly Lys Lys Pro His Met 
            180                 185                 190         


Phe Pro Arg Pro Pro Val Leu Thr Pro Ile Phe Ile Pro Gly Thr Asp 
        195                 200                 205             


Ile Leu Val Arg Gly Ser Asn Gln Asp Ile Ala Ile Asn Pro Met Leu 
    210                 215                 220                 


Ser Asp Glu Thr Asn Leu Cys Asn Gly Lys Pro Val Asp Gly Leu Thr 
225                 230                 235                 240 


Thr Leu Arg Asn Gly Thr Met Val Ala Phe Arg Gly His Tyr Phe Trp 
                245                 250                 255     


Met Leu Ser Pro Ser Lys Pro Pro Ser Pro Pro Arg Lys Ile Thr Glu 
            260                 265                 270         


Val Trp Gly Ile Pro Ser Pro Ile Asp Thr Val Phe Thr Arg Cys Asn 
        275                 280                 285             


Cys Glu Gly Lys Thr Phe Phe Phe Lys Gly Ser Gln Tyr Trp Arg Phe 
    290                 295                 300                 


Thr Asn Asp Ile Lys Asp Ala Gly Tyr Pro Lys Gln Ile Val Lys Gly 
305                 310                 315                 320 


Phe Gly Gly Leu Asn Gly Arg Ile Val Ala Ala Leu Ser Ile Ala Lys 
                325                 330                 335     


Tyr Lys Asp Arg Pro Glu Ser Val Tyr Phe Phe Lys Arg Gly Gly Ser 
            340                 345                 350         


Val Gln Gln Tyr Thr Tyr Lys Gln Glu Pro Ile Lys Lys Cys Thr Gly 
        355                 360                 365             


Arg Arg Pro Ala Ile Asn Tyr Pro Val Tyr Gly Glu Thr Thr Gln Val 
    370                 375                 380                 


Arg Arg Arg Arg Phe Glu Arg Ala Ile Gly Pro Ser Gln Thr His Thr 
385                 390                 395                 400 


Ile Arg Ile His Tyr Ser Pro Ile Arg Val Ser Tyr Gln Asp Lys Gly 
                405                 410                 415     


Phe Leu His Asn Glu Val Lys Met Ser Ser Gln Trp Arg Gly Phe Pro 
            420                 425                 430         


Asn Val Val Thr Ser Ala Ile Ala Leu Pro Asn Ile Arg Lys Pro Asp 
        435                 440                 445             


Gly Tyr Asp Tyr Tyr Ala Phe Ser Arg Asn Gln Tyr Tyr Asn Ile Asp 
    450                 455                 460                 


Val Pro Ser Arg Thr Ala Arg Val Val Thr Thr Arg Phe Gly Arg Thr 
465                 470                 475                 480 


Leu Ser Asn Ile Trp Tyr Asn Cys 
                485             


<210>  79
<211>  320
<212>  PRT
<213>  Equus ferus caballus

<400>  79

Gln Asp Leu Ser Ser Cys Ala Gly Arg Cys Gly Glu Gly Tyr Ser Arg 
1               5                   10                  15      


Asp Ala Thr Cys Asn Cys Asp Phe Asn Cys Gln Tyr Tyr Met Glu Cys 
            20                  25                  30          


Cys Pro Asp Phe Lys Lys Val Cys Thr Ser Glu Leu Ser Cys Lys Gly 
        35                  40                  45              


Arg Cys Phe Glu Ser Phe Glu Arg Gly Arg Glu Cys Asp Cys Asp Ala 
    50                  55                  60                  


Asp Cys Lys Lys Tyr Gly Lys Cys Cys Ser Asp Tyr Glu Ser Phe Cys 
65                  70                  75                  80  


Glu Glu Val His Asn Pro Thr Ser Pro Pro Ser Ser Lys Thr Ala Pro 
                85                  90                  95      


Pro Pro Pro Gly Ala Ser Gln Thr Ile Lys Ser Thr Ala Lys Arg Ser 
            100                 105                 110         


Pro Lys Ser Asn Lys Lys Lys Thr Lys Lys Val Ile Glu Ser Glu Glu 
        115                 120                 125             


Ile Ile Glu Glu His Ser Val Ser Glu Asn Gln Glu Ser Ser Ser Ser 
    130                 135                 140                 


Ser Ser Ser Ser Ser Ser Thr Ile Arg Lys Val Lys Ser Ser Lys Asn 
145                 150                 155                 160 


Ser Ala Ala Asn Arg Glu Leu Lys Lys Lys Pro Lys Val Lys Asp Ser 
                165                 170                 175     


Lys Lys Lys Arg Thr Pro Lys Lys Lys Pro Thr Pro Glu Pro Pro Val 
            180                 185                 190         


Ile Asp Glu Ala Gly Ser Gly Leu Asp Asn Gly Asp Phe Met Leu Ile 
        195                 200                 205             


Pro Thr Pro Lys Ile Pro Thr Thr Gln Arg Asn Lys Val Thr Thr Ser 
    210                 215                 220                 


Pro Lys Ile Thr Thr Val Lys Pro Ile Asn Pro Lys Pro Ser Leu Pro 
225                 230                 235                 240 


Pro Asn Ser Asp Thr Ser Lys Glu Thr Thr Ser Thr Pro Asn Lys Glu 
                245                 250                 255     


Thr Thr Val Glu Thr Lys Glu Thr Glu Ile Thr Asn Lys Glu Thr Ser 
            260                 265                 270         


Thr Ser Ala Asn Glu Lys Thr Thr Ser Ala Arg Lys Ser Thr Glu Lys 
        275                 280                 285             


Thr Ser Asp Lys Asp Phe Ala Pro Ala Ser Glu Val Pro Ala Lys Ser 
    290                 295                 300                 


Thr Pro Lys Ala Glu Thr Thr Thr Lys Gly Pro Ala Leu Thr Thr Pro 
305                 310                 315                 320 


<210>  80
<211>  554
<212>  PRT
<213>  Equus ferus caballus

<400>  80

Ser Glu Val Ser Thr Thr Thr Thr Thr Met Lys Pro Pro Thr Thr Pro 
1               5                   10                  15      


Lys Asn Leu Ala Glu Ser Thr Pro Glu Phe Pro Ala Glu Pro Thr Pro 
            20                  25                  30          


Lys Ala Leu Glu Asn Ser Pro Lys Glu Pro Ala Val Pro Thr Thr Lys 
        35                  40                  45              


Ala Pro Glu Val Thr Lys Pro Glu Val Thr Thr Thr Ala Lys Asp Lys 
    50                  55                  60                  


Val Thr Gly Lys Asp Ile His Thr Ile Pro Glu Ile Thr Thr Ala Ala 
65                  70                  75                  80  


Pro Lys Ile Thr Thr Glu Thr Ala Thr Thr Thr Glu Glu Lys Thr Thr 
                85                  90                  95      


Glu Ser Lys Val Thr Ser Thr Ile Met Gln Val Thr Ser Thr Thr Glu 
            100                 105                 110         


Asp Thr Thr Thr Ser Ser Lys Ile Thr Pro Lys Ala Thr Thr Leu Ala 
        115                 120                 125             


Pro Lys Val Met Thr Ala Thr Lys Thr Thr Thr Thr Gln Glu Thr Ile 
    130                 135                 140                 


Asn Lys Leu Glu Glu Thr Thr Ala Ile Pro Lys Asp Thr Ala Thr His 
145                 150                 155                 160 


Ser Lys Val Thr Thr Pro Lys Pro Lys Lys Pro Thr Lys Ala Pro Arg 
                165                 170                 175     


Lys Pro Thr Ser Thr Lys Lys Pro Lys Thr Pro Arg Lys Arg Lys Pro 
            180                 185                 190         


Lys Thr Thr Pro Ile Pro Pro Lys Ile Thr Thr Pro Thr Thr Pro Lys 
        195                 200                 205             


Ser Asn Pro Thr Thr Leu Ala Glu Ala Met Leu Gln Thr Thr Thr Ser 
    210                 215                 220                 


Pro Asn Gln Thr Pro Asn Ser Ala Met Ile Glu Val Asn Pro Lys Asn 
225                 230                 235                 240 


Glu Asp Ala Asp Ala Ala Glu Gly Glu Lys Pro Leu Val Ile Leu Arg 
                245                 250                 255     


Pro His Val Leu Thr Pro Ile Val Ile Pro Gly Pro Asp Phe Leu Val 
            260                 265                 270         


Arg Gly Pro Asn Leu Gly Ile Gly Ile Asn Pro Met Leu Ser Asp Glu 
        275                 280                 285             


Thr Asn Leu Cys Asn Gly Lys Pro Val Asp Gly Leu Thr Thr Leu Arg 
    290                 295                 300                 


Asn Gly Thr Leu Val Ala Phe Arg Gly His Tyr Phe Trp Met Leu Arg 
305                 310                 315                 320 


Pro Phe Ser Pro Pro Ser Pro Pro Arg Arg Ile Thr Glu Val Trp Gly 
                325                 330                 335     


Ile Pro Ser Pro Ile Asp Thr Val Phe Thr Arg Cys Asn Cys Glu Gly 
            340                 345                 350         


Lys Thr Phe Phe Phe Lys Asp Ser Gln Tyr Trp Arg Phe Thr Asn Asp 
        355                 360                 365             


Ile Lys Asp Ala Gly Tyr Pro Lys Leu Ile Ser Lys Gly Phe Gly Gly 
    370                 375                 380                 


Leu Ser Gly Lys Ile Val Ala Ala Leu Ser Ile Ala Thr Tyr Lys Asn 
385                 390                 395                 400 


Arg Pro Glu Ser Val Tyr Phe Phe Lys Arg Gly Gly Arg Ile Gln Gln 
                405                 410                 415     


Tyr Ile Tyr Lys Gln Glu Pro Ile Arg Lys Cys Pro Gly Arg Arg Pro 
            420                 425                 430         


Ala Ile His Tyr Ser Val Tyr Gly Glu Ala Pro Gln Ile Arg Arg Arg 
        435                 440                 445             


Arg Phe Glu Arg Ala Ile Gly Pro Ser Gln Thr His Thr Ile Arg Ile 
    450                 455                 460                 


His Tyr Ser Pro Val Arg Val Ser Tyr Gln Asp Lys Val Pro Ser Thr 
465                 470                 475                 480 


Asp Phe Leu His Asn Glu Val Lys Val Ser Thr Leu Trp Arg Gly Leu 
                485                 490                 495     


Pro Asp Thr Val Thr Ser Ala Ile Ser Leu Pro Asn Leu Arg Lys Pro 
            500                 505                 510         


Asp Gly Tyr Asp Tyr Tyr Ala Phe Ser Lys Asp Gln Tyr Tyr Asn Ile 
        515                 520                 525             


Asp Val Pro Ser Arg Thr Ala Arg Ala Ile Thr Thr Arg Ser Gly Gln 
    530                 535                 540                 


Thr Leu Ser Lys Val Trp Tyr Asn Cys Pro 
545                 550                 


<210>  81
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant secretory signal

<400>  81

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp 
            20      


<210>  82
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant secretory signal

<400>  82

Met Gln Trp Lys Ile Leu Pro Ile Tyr Leu Leu Leu Leu Ser Val Phe 
1               5                   10                  15      


Leu Ile Gln Gln Val Ser Ser 
            20              


<210>  83
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Altered canine sequence

<400>  83

Ser Pro Ala Pro Thr Thr Pro 
1               5           


<210>  84
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  Modified equine sequence

<400>  84

Ser Pro Ser Leu Thr Thr 
1               5       


<210>  85
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  85
atgacaccgg gcacccagtc                                                   20


<210>  86
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  86
ctacatactt cgtcggcgca tgtac                                             25


<210>  87
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  Consensus sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  87

Lys Xaa Pro Xaa Pro Thr Thr Xaa 
1               5               


<210>  88
<211>  33
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  88
ggcacctcga ggatgccggt gcagctgacg aca                                    33


<210>  89
<211>  34
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  89
ggcagaattc ttacacctca gcaaaagcca agct                                   34


<210>  90
<211>  37
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  90
ggcagctcag ctatggtgtc caagggcgag gagctgt                                37


<210>  91
<211>  39
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  91
ggcagctgag cccttataca gctcgtccat gccgtgagt                              39


<210>  92
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  92
tggaggagcc tcaggcatac tttattg                                           27


<210>  93
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  93
ccaccgccga ccgaggtgac atcctg                                            26


<210>  94
<211>  37
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  94
gttgcgactg cttaacggac agatctcgat ggtgagc                                37


<210>  95
<211>  39
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  95
agccagctca gggaatcccc agcattcttc tcagtagag                              39


<210>  96
<211>  41
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  96
tcaggccacc accaccatca ccatcatcac caccattagg g                           41


<210>  97
<211>  42
<212>  DNA
<213>  artificial sequence

<220>
<223>  Primer

<400>  97
ccggtggtgg tggtagtggt agtagtggtg gtaatccctt aa                          42


<210>  98
<211>  1369
<212>  PRT
<213>  artificial sequence

<220>
<223>  Recombinant equine SynLubricin

<400>  98

Glu Trp Lys Ile Leu Pro Ile Tyr Leu Leu Leu Leu Leu Ser Ile Phe 
1               5                   10                  15      


Ser Ile Gln Glu Val Ser Ser Gln Asp Leu Ser Ser Cys Ala Gly Arg 
            20                  25                  30          


Cys Gly Glu Gly Tyr Ser Arg Asp Ala Thr Cys Asn Cys Asp Phe Asn 
        35                  40                  45              


Cys Gln Tyr Tyr Met Glu Cys Cys Pro Asp Phe Lys Lys Val Cys Thr 
    50                  55                  60                  


Ser Glu Leu Ser Cys Lys Gly Arg Cys Phe Glu Ser Phe Glu Arg Gly 
65                  70                  75                  80  


Arg Glu Cys Asp Cys Asp Ala Asp Cys Lys Lys Tyr Gly Lys Cys Cys 
                85                  90                  95      


Ser Asp Tyr Glu Ser Phe Cys Glu Glu Val His Asn Pro Thr Ser Pro 
            100                 105                 110         


Pro Ser Ser Lys Thr Ala Pro Pro Pro Pro Gly Ala Ser Gln Thr Ile 
        115                 120                 125             


Lys Ser Thr Ala Lys Arg Ser Pro Lys Ser Asn Lys Lys Lys Thr Lys 
    130                 135                 140                 


Lys Val Ile Glu Ser Glu Glu Ile Ile Glu Glu His Ser Val Ser Glu 
145                 150                 155                 160 


Asn Gln Glu Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Thr Ile Arg 
                165                 170                 175     


Lys Val Lys Ser Ser Lys Asn Ser Ala Ala Asn Arg Glu Leu Lys Lys 
            180                 185                 190         


Lys Pro Lys Val Lys Asp Ser Lys Lys Lys Arg Thr Pro Lys Lys Lys 
        195                 200                 205             


Pro Thr Pro Glu Pro Pro Val Ile Asp Glu Ala Gly Ser Gly Leu Asp 
    210                 215                 220                 


Asn Gly Asp Phe Met Leu Ile Pro Thr Pro Lys Ile Pro Thr Thr Gln 
225                 230                 235                 240 


Arg Asn Lys Val Thr Thr Ser Pro Lys Ile Thr Thr Val Lys Pro Ile 
                245                 250                 255     


Asn Pro Lys Pro Ser Leu Pro Pro Asn Ser Asp Thr Ser Lys Glu Thr 
            260                 265                 270         


Thr Ser Thr Pro Asn Lys Glu Thr Thr Val Glu Thr Lys Glu Thr Glu 
        275                 280                 285             


Ile Thr Asn Lys Glu Thr Ser Thr Ser Ala Asn Glu Lys Thr Thr Ser 
    290                 295                 300                 


Ala Arg Lys Ser Thr Glu Lys Thr Ser Asp Lys Asp Phe Ala Pro Ala 
305                 310                 315                 320 


Ser Glu Val Pro Ala Lys Ser Thr Pro Lys Ala Glu Thr Thr Thr Lys 
                325                 330                 335     


Gly Pro Ala Leu Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
            340                 345                 350         


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
        355                 360                 365             


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
    370                 375                 380                 


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
385                 390                 395                 400 


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
                405                 410                 415     


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
            420                 425                 430         


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
        435                 440                 445             


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
    450                 455                 460                 


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
465                 470                 475                 480 


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
                485                 490                 495     


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
            500                 505                 510         


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
        515                 520                 525             


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
    530                 535                 540                 


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
545                 550                 555                 560 


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
                565                 570                 575     


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
            580                 585                 590         


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
        595                 600                 605             


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
    610                 615                 620                 


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
625                 630                 635                 640 


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
                645                 650                 655     


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
            660                 665                 670         


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
        675                 680                 685             


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
    690                 695                 700                 


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
705                 710                 715                 720 


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
                725                 730                 735     


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
            740                 745                 750         


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
        755                 760                 765             


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
    770                 775                 780                 


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Lys 
785                 790                 795                 800 


Glu Pro Ala Pro Thr Thr Pro Lys Glu Pro Ala Pro Thr Thr Pro Ser 
                805                 810                 815     


Glu Val Ser Thr Thr Thr Thr Thr Met Lys Pro Pro Thr Thr Pro Lys 
            820                 825                 830         


Asn Leu Ala Glu Ser Thr Pro Glu Phe Pro Ala Glu Pro Thr Pro Lys 
        835                 840                 845             


Ala Leu Glu Asn Ser Pro Lys Glu Pro Ala Val Pro Thr Thr Lys Ala 
    850                 855                 860                 


Pro Glu Val Thr Lys Pro Glu Val Thr Thr Thr Ala Lys Asp Lys Val 
865                 870                 875                 880 


Thr Gly Lys Asp Ile His Thr Ile Pro Glu Ile Thr Thr Ala Ala Pro 
                885                 890                 895     


Lys Ile Thr Thr Glu Thr Ala Thr Thr Thr Glu Glu Lys Thr Thr Glu 
            900                 905                 910         


Ser Lys Val Thr Ser Thr Ile Met Gln Val Thr Ser Thr Thr Glu Asp 
        915                 920                 925             


Thr Thr Thr Ser Ser Lys Ile Thr Pro Lys Ala Thr Thr Leu Ala Pro 
    930                 935                 940                 


Lys Val Met Thr Ala Thr Lys Thr Thr Thr Thr Gln Glu Thr Ile Asn 
945                 950                 955                 960 


Lys Leu Glu Glu Thr Thr Ala Ile Pro Lys Asp Thr Ala Thr His Ser 
                965                 970                 975     


Lys Val Thr Thr Pro Lys Pro Lys Lys Pro Thr Lys Ala Pro Arg Lys 
            980                 985                 990         


Pro Thr Ser Thr Lys Lys Pro Lys  Thr Pro Arg Lys Arg  Lys Pro Lys 
        995                 1000                 1005             


Thr Thr  Pro Ile Pro Pro Lys  Ile Thr Thr Pro Thr  Thr Pro Lys 
    1010                 1015                 1020             


Ser Asn  Pro Thr Thr Leu Ala  Glu Ala Met Leu Gln  Thr Thr Thr 
    1025                 1030                 1035             


Ser Pro  Asn Gln Thr Pro Asn  Ser Ala Met Ile Glu  Val Asn Pro 
    1040                 1045                 1050             


Lys Asn  Glu Asp Ala Asp Ala  Ala Glu Gly Glu Lys  Pro Leu Val 
    1055                 1060                 1065             


Ile Leu  Arg Pro His Val Leu  Thr Pro Ile Val Ile  Pro Gly Pro 
    1070                 1075                 1080             


Asp Phe  Leu Val Arg Gly Pro  Asn Leu Gly Ile Gly  Ile Asn Pro 
    1085                 1090                 1095             


Met Leu  Ser Asp Glu Thr Asn  Leu Cys Asn Gly Lys  Pro Val Asp 
    1100                 1105                 1110             


Gly Leu  Thr Thr Leu Arg Asn  Gly Thr Leu Val Ala  Phe Arg Gly 
    1115                 1120                 1125             


His Tyr  Phe Trp Met Leu Arg  Pro Phe Ser Pro Pro  Ser Pro Pro 
    1130                 1135                 1140             


Arg Arg  Ile Thr Glu Val Trp  Gly Ile Pro Ser Pro  Ile Asp Thr 
    1145                 1150                 1155             


Val Phe  Thr Arg Cys Asn Cys  Glu Gly Lys Thr Phe  Phe Phe Lys 
    1160                 1165                 1170             


Asp Ser  Gln Tyr Trp Arg Phe  Thr Asn Asp Ile Lys  Asp Ala Gly 
    1175                 1180                 1185             


Tyr Pro  Lys Leu Ile Ser Lys  Gly Phe Gly Gly Leu  Ser Gly Lys 
    1190                 1195                 1200             


Ile Val  Ala Ala Leu Ser Ile  Ala Thr Tyr Lys Asn  Arg Pro Glu 
    1205                 1210                 1215             


Ser Val  Tyr Phe Phe Lys Arg  Gly Gly Arg Ile Gln  Gln Tyr Ile 
    1220                 1225                 1230             


Tyr Lys  Gln Glu Pro Ile Arg  Lys Cys Pro Gly Arg  Arg Pro Ala 
    1235                 1240                 1245             


Ile His  Tyr Ser Val Tyr Gly  Glu Ala Pro Gln Ile  Arg Arg Arg 
    1250                 1255                 1260             


Arg Phe  Glu Arg Ala Ile Gly  Pro Ser Gln Thr His  Thr Ile Arg 
    1265                 1270                 1275             


Ile His  Tyr Ser Pro Val Arg  Val Ser Tyr Gln Asp  Lys Val Pro 
    1280                 1285                 1290             


Ser Thr  Asp Phe Leu His Asn  Glu Val Lys Val Ser  Thr Leu Trp 
    1295                 1300                 1305             


Arg Gly  Leu Pro Asp Thr Val  Thr Ser Ala Ile Ser  Leu Pro Asn 
    1310                 1315                 1320             


Leu Arg  Lys Pro Asp Gly Tyr  Asp Tyr Tyr Ala Phe  Ser Lys Asp 
    1325                 1330                 1335             


Gln Tyr  Tyr Asn Ile Asp Val  Pro Ser Arg Thr Ala  Arg Ala Ile 
    1340                 1345                 1350             


Thr Thr  Arg Ser Gly Gln Thr  Leu Ser Lys Val Trp  Tyr Asn Cys 
    1355                 1360                 1365             


Pro 
    


<210>  99
<211>  187
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA

<400>  99
tgtacatgga catggtcgct gtgagtatga ccagcagcgt actctccagc cacagccccg       60

gttcaggctc ctccaccact cagggacagg atgtcactct ggccccggcc acggaaccag      120

cttcaggttc agctgccacc tggggacagg atgtcacctc ggtcggcggt ggtggaggag      180

cctcagg                                                                187


