                         SEQUENCE LISTING

<110>  Altor Bioscience LLC
       National Institutes of Health
       Rhode, Peter
       Connors, Mark
       Migueles, Stephen
 
<120>  HUMAN IMMUNODEFICIENCY VIRUS-SPECIFIC T CELL RECEPTORS

<130>  048277-539P01WO

<150>  US 62/792,880
<151>  2019-01-15

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  1245
<212>  DNA
<213>  Homo sapiens

<400>  1
atggagacag acacactcct gttatgggta ctgttactct gggtgccagg tagtaccggt       60

agtcaacagg gagaagagga tcctcaggcc ttgagcatcc aggagggtga aaatgccacc      120

atgaactgca gttacaaaac tagtataaac aatttacagt ggtatagaca aaattcaggt      180

agaggccttg tccacctaat tttaatacgt tcaaatgaaa gagagaaaca cagtgggaga      240

ttaagagtca cgcttgacac ttccaagaaa agcagttcct tgttgatcac ggcttcccgg      300

gcagcagaca ctgcttctta cttctgtgct acggacgcta tcgacaagct catctttggg      360

actgggacca gattacaagt ctttccgact agtggaggag gtgggagcgg aggtggtgct      420

agcggtggcg gcggttctgg cggtggcggt tcctcaagcg attctggagt cacacaaacc      480

ccaaagcacc tgatcacagc aactggacag cgagtgacgc tgagatgctc ccctaggtct      540

ggagacctct ctgtgtactg gtaccaacag agcctggacc agggcctcca gttcctcatt      600

cagtattata atggagaaga gagagcaaaa ggaaacattc ttgaacgatt ctccgcacaa      660

cagttccctg acttgcactc tgaactaaac ctgagctctc tggagctggg ggactcagct      720

ttgtatttct gtgccagcag cgtagttggg gacagccgag agacccagta cttcgggcca      780

ggcacgcggc tcctggtgct cgaggacctg aacaaggtgt tcccacccga ggtcgctgtg      840

tttgagccat cagaagcaga gatctcccac acccaaaagg ccacactggt gtgcctggcc      900

acaggcttct tccctgacca cgtggagctg agctggtggg tgaatgggaa ggaggtgcac      960

agtggggtca gcacggaccc gcagcccctc aaggagcagc ccgccctcaa tgactccaga     1020

tactgcctga gcagccgcct gagggtctcg gccaccttct ggcagaaccc ccgcaaccac     1080

ttccgctgtc aagtccagtt ctacgggctc tcggagaatg acgagtggac ccaggatagg     1140

gccaaacccg tcacccagat cgtcagcgcc gaggcctggg gtagagcaga cgttaacggt     1200

ggtctgaacg acatcttcga agctcagaaa attgaatggc acgaa                     1245


<210>  2
<211>  415
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (48)..(51)
<223>  Complementarity determining region 1 (CDR1) V alpha

<220>
<221>  SITE
<222>  (70)..(75)
<223>  Complementarity determining region 2 (CDR2) V alpha

<220>
<221>  SITE
<222>  (110)..(118)
<223>  Complementarity determining region 3 (CDR3) V alpha

<220>
<221>  DOMAIN
<222>  (142)..(151)
<223>  Linker

<220>
<221>  SITE
<222>  (180)..(184)
<223>  CDR1 V beta

<220>
<221>  SITE
<222>  (202)..(207)
<223>  CDR2 V beta

<220>
<221>  SITE
<222>  (245)..(257)
<223>  CDR3 V beta

<220>
<221>  DOMAIN
<222>  (398)..(415)
<223>  BirA tag

<400>  2

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Ala Ile Asp Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val Phe 
        115                 120                 125             


Pro Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Ser Ser Asp Ser Gly Val Thr Gln Thr 
145                 150                 155                 160 


Pro Lys His Leu Ile Thr Ala Thr Gly Gln Arg Val Thr Leu Arg Cys 
                165                 170                 175     


Ser Pro Arg Ser Gly Asp Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu 
            180                 185                 190         


Asp Gln Gly Leu Gln Phe Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg 
        195                 200                 205             


Ala Lys Gly Asn Ile Leu Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp 
    210                 215                 220                 


Leu His Ser Glu Leu Asn Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala 
225                 230                 235                 240 


Leu Tyr Phe Cys Ala Ser Ser Val Val Gly Asp Ser Arg Glu Thr Gln 
                245                 250                 255     


Tyr Phe Gly Pro Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Asn Lys 
            260                 265                 270         


Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile 
        275                 280                 285             


Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe 
    290                 295                 300                 


Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His 
305                 310                 315                 320 


Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu 
                325                 330                 335     


Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
            340                 345                 350         


Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr 
        355                 360                 365             


Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val 
    370                 375                 380                 


Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Val Asn Gly 
385                 390                 395                 400 


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
                405                 410                 415 


<210>  3
<211>  1272
<212>  DNA
<213>  Homo sapiens

<400>  3
atggagacag acacactcct gttatgggta ctgctgctct gggttccagg ttccaccggt       60

gctcagaagg taactcaagc gcagactgaa atttctgtgg tggagaagga ggatgtgacc      120

ttggactgtg tgtatgaaac ccgtgatact acttattact tattctggta caagcaacca      180

ccaagtggag aattggtttt cgttattcgt cggaactctt ttgatgagca aaatgaaata      240

agtggtcggt attcttggaa cttccagaaa tccaccagtt ccttcaactt caccatcaca      300

gcctcacaag tcgtggactc agcagtatac ttctgtgctc tgaaaagcta cgacagaggc      360

tcaaccctgg ggaggctata ctttggaaga ggaactcagt tgactgtctg gcctactagt      420

ggaggaggtg ggagcggagg tggtgctagc ggtggcggcg gttctggcgg tggcggttcc      480

tcaagcgaac ctgaagtcac ccagactccc agccatcagg tcacacagat gggacaggaa      540

gtgatcttgc gctgtgtccc catctctaat cacttatact tctattggta cagacaaatc      600

ttggggcaga aagtcgagtt tctggtttcc ttttataata atgaaatctc agagaagtct      660

gaaatattcg atgatcaatt ctcagttgaa aggcctgatg gatcaaattt cactctgaag      720

atccggtcca caaagctgga ggactcagcc atgtacttct gtgccagcag tgaatggggc      780

gagaatgaaa aactgttttt tggcagtgga acccagctct ctgtcttgga ggacctgaac      840

aaggtgttcc cacccgaggt cgctgtgttt gagccatcag aagcagagat ctcccacacc      900

caaaaggcca cactggtgtg cctggccaca ggcttcttcc ctgaccacgt ggagctgagc      960

tggtgggtga atgggaagga ggtgcacagt ggggtcagca cggacccgca gcccctcaag     1020

gagcagcccg ccctcaatga ctccagatac tgcctgagca gccgcctgag ggtctcggcc     1080

accttctggc agaacccccg caaccacttc cgctgtcaag tccagttcta cgggctctcg     1140

gagaatgacg agtggaccca ggatagggcc aaacccgtca cccagatcgt cagcgccgag     1200

gcctggggta gagcagacgt taacggtggt ctgaacgaca tcttcgaagc tcagaaaatt     1260

gaatggcacg aa                                                         1272


<210>  4
<211>  425
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(19)

<220>
<221>  SITE
<222>  (47)..(53)
<223>  CDR1 V alpha

<220>
<221>  SITE
<222>  (71)..(78)
<223>  CDR2 V alpha

<220>
<221>  SITE
<222>  (113)..(127)
<223>  CDR3 V alpha

<220>
<221>  DOMAIN
<222>  (141)..(161)
<223>  Linker

<220>
<221>  SITE
<222>  (190)..(194)
<223>  CDR1 V beta

<220>
<221>  SITE
<222>  (212)..(217)
<223>  CDR2 V beta

<220>
<221>  SITE
<222>  (256)..(267)
<223>  CDR3 V beta

<220>
<221>  DOMAIN
<222>  (408)..(425)
<223>  BirA tag

<400>  4

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Val Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Lys Ser Tyr Asp Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe 
        115                 120                 125             


Gly Arg Gly Thr Gln Leu Thr Val Trp Pro Thr Ser Gly Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Ser Ser Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
                165                 170                 175     


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
            180                 185                 190         


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
        195                 200                 205             


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
    210                 215                 220                 


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
225                 230                 235                 240 


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
                245                 250                 255     


Ser Ser Glu Trp Gly Glu Asn Glu Lys Leu Phe Phe Gly Ser Gly Thr 
            260                 265                 270         


Gln Leu Ser Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val 
        275                 280                 285             


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
    290                 295                 300                 


Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu 
305                 310                 315                 320 


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
                325                 330                 335     


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
            340                 345                 350         


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
        355                 360                 365             


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
    370                 375                 380                 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
385                 390                 395                 400 


Glu Ala Trp Gly Arg Ala Asp Val Asn Gly Gly Leu Asn Asp Ile Phe 
                405                 410                 415     


Glu Ala Gln Lys Ile Glu Trp His Glu 
            420                 425 


<210>  5
<211>  1245
<212>  DNA
<213>  Homo sapiens

<400>  5
atggagacag acacactcct gttatgggta ctgctgctct gggttccagg ttccaccggt       60

agtcaacagg gagaagagga tcctcaggcc ttgagcatcc aggagggtga aaatgccacc      120

atgaactgca gttacaaaac tagtataaac aatttacagt ggtatagaca aaattcaggt      180

agaggccttg tccacctaat tttaatacgt tcaaatgaaa gagagaaaca cagtggaaga      240

ttaagagtca cgcttgacac ttccaagaaa agcagttcct tgttgatcac ggcttcccgg      300

gcagcagaca ctgcttctta cttctgtgct acggacggca aggcaggaac tgctctgatc      360

tttgggaagg gaaccacctt atcagtgagt tccactagtg gaggaggtgg gagcggaggt      420

ggtgctagcg gtggcggcgg ttctggcggt ggcggttcct caagcgaagc ccaagtgacc      480

cagaacccaa gatacctcat cacagtgact ggaaagaagt taacagtgac ttgttctcag      540

aatatgaacc atgagtatat gtcctggtat cgacaagacc cagggctggg cttaaggcag      600

atctactatt caatgaatgt tgaggtgact gataagggag atgttcctga agggtacaaa      660

gtctctcgaa aagagaagag gaatttcccc ctgatcctgg agtcgcccag ccccaaccag      720

acctctctgt acttctgtgc cagcagtttg gggaccttaa gtgagcagtt cttcgggcca      780

gggacacggc tcaccgtgct agaggacctg aacaaggtgt tcccacccga ggtcgctgtg      840

tttgagccat cagaagcaga gatctcccac acccaaaagg ccacactggt gtgcctggcc      900

acaggcttct tccctgacca cgtggagctg agctggtggg tgaatgggaa ggaggtgcac      960

agtggggtca gcacggaccc gcagcccctc aaggagcagc ccgccctcaa tgactccaga     1020

tactgcctga gcagccgcct gagggtctcg gccaccttct ggcagaaccc ccgcaaccac     1080

ttccgctgtc aagtccagtt ctacgggctc tcggagaatg acgagtggac ccaggatagg     1140

gccaaacccg tcacccagat cgtcagcgcc gaggcctggg gtagagcaga cgttaacggt     1200

ggtctgaacg acatcttcga agctcagaaa attgaatggc acgaa                     1245


<210>  6
<211>  415
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (47)..(51)
<223>  CDR1 V alpha

<220>
<221>  SITE
<222>  (69)..(75)
<223>  CDR2 V alpha

<220>
<221>  SITE
<222>  (110)..(120)
<223>  CDR3 V alpha

<220>
<221>  DOMAIN
<222>  (134)..(153)
<223>  Linker

<220>
<221>  SITE
<222>  (182)..(186)
<223>  CDR1 V beta

<220>
<221>  SITE
<222>  (204)..(209)
<223>  CDR2 V beta

<220>
<221>  SITE
<222>  (247)..(257)
<223>  CDR3 V beta

<220>
<221>  DOMAIN
<222>  (398)..(415)
<223>  BirA tag

<400>  6

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Gly Lys Ala Gly Thr Ala Leu Ile Phe Gly Lys Gly Thr Thr Leu Ser 
        115                 120                 125             


Val Ser Ser Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Glu Ala Gln Val Thr 
145                 150                 155                 160 


Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly Lys Lys Leu Thr Val 
                165                 170                 175     


Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met Ser Trp Tyr Arg Gln 
            180                 185                 190         


Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr Ser Met Asn Val Glu 
        195                 200                 205             


Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr Lys Val Ser Arg Lys 
    210                 215                 220                 


Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser Pro Ser Pro Asn Gln 
225                 230                 235                 240 


Thr Ser Leu Tyr Phe Cys Ala Ser Ser Leu Gly Thr Leu Ser Glu Gln 
                245                 250                 255     


Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Asn Lys 
            260                 265                 270         


Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile 
        275                 280                 285             


Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe 
    290                 295                 300                 


Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His 
305                 310                 315                 320 


Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu 
                325                 330                 335     


Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
            340                 345                 350         


Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr 
        355                 360                 365             


Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val 
    370                 375                 380                 


Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Val Asn Gly 
385                 390                 395                 400 


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
                405                 410                 415 


<210>  7
<211>  1263
<212>  DNA
<213>  Homo sapiens

<400>  7
atggagacag acacactcct gttatgggta ctgctgctct gggttccagg ttccaccggt       60

cagaaggagg tggagcagaa ttctggaccc ctcagtgttc cagagggagc cattgcctct      120

ctcaactgca cttacagtga ccgaggttcc cagtccttct tctggtacag acaatattct      180

gggaaaagcc ctgagttgat aatgtccata tactccaatg gtgacaaaga agatggaagg      240

tttacagcac agctcaataa agccagccag tatgtttctc tgctcatcag agactcccag      300

cccagtgatt cagccaccta cctctgtgcc gtgagaattc agggagccca gaagctggta      360

tttggccaag gaaccaggct gactatcaac ccaactagtg gaggaggtgg gagcggaggt      420

ggtgctagcg gtggcggcgg ttctggcggt ggcggttcct caagcgatgc tggaatcacc      480

cagagcccaa gacacaaggt cacagagaca ggaacaccag tgactctgag atgtcaccag      540

actgagaacc accgctacat gtactggtat cgacaagacc cggggcatgg gctgaggcta      600

atccattact catatggtgt taaagatact gacaaaggag aagtctcaga tggctatagt      660

gtctctagat caaagacaga ggatttcctc ctcactctgg agtccgctac cagctcccag      720

acatctgtgt acttctgtgc catcagtgag tcggcaggga aatcgggtag cacggcctac      780

gagcagtact tcgggccggg caccaggctc acggtcacag aggacctgaa caaggtgttc      840

ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc      900

acactggtgt gcctggccac aggcttcttc cctgaccacg tggagctgag ctggtgggtg      960

aatgggaagg aggtgcacag tggggtcagc acggacccgc agcccctcaa ggagcagccc     1020

gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg     1080

cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac     1140

gagtggaccc aggatagggc caaacccgtc acccagatcg tcagcgccga ggcctggggt     1200

agagcagacg ttaacggtgg tctgaacgac atcttcgaag ctcagaaaat tgaatggcac     1260

gaa                                                                   1263


<210>  8
<211>  421
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (47)..(52)
<223>  CDR1 V alpha

<220>
<221>  SITE
<222>  (70)..(75)
<223>  CDR2 V alpha

<220>
<221>  SITE
<222>  (110)..(120)
<223>  CDR3 V alpha

<220>
<221>  DOMAIN
<222>  (134)..(153)
<223>  Linker

<220>
<221>  SITE
<222>  (182)..(187)
<223>  CDR1 V beta

<220>
<221>  SITE
<222>  (204)..(209)
<223>  CDR2 V beta

<220>
<221>  SITE
<222>  (247)..(264)
<223>  CDR3 V beta

<220>
<221>  DOMAIN
<222>  (404)..(421)

<400>  8

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser 
            20                  25                  30          


Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg 
        35                  40                  45              


Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro 
    50                  55                  60                  


Glu Leu Ile Met Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg 
65                  70                  75                  80  


Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile 
                85                  90                  95      


Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Ile Gln Gly Ala Gln Lys Leu Val Phe Gly Gln Gly Thr Arg Leu Thr 
        115                 120                 125             


Ile Asn Pro Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Asp Ala Gly Ile Thr 
145                 150                 155                 160 


Gln Ser Pro Arg His Lys Val Thr Glu Thr Gly Thr Pro Val Thr Leu 
                165                 170                 175     


Arg Cys His Gln Thr Glu Asn His Arg Tyr Met Tyr Trp Tyr Arg Gln 
            180                 185                 190         


Asp Pro Gly His Gly Leu Arg Leu Ile His Tyr Ser Tyr Gly Val Lys 
        195                 200                 205             


Asp Thr Asp Lys Gly Glu Val Ser Asp Gly Tyr Ser Val Ser Arg Ser 
    210                 215                 220                 


Lys Thr Glu Asp Phe Leu Leu Thr Leu Glu Ser Ala Thr Ser Ser Gln 
225                 230                 235                 240 


Thr Ser Val Tyr Phe Cys Ala Ile Ser Glu Ser Ala Gly Lys Ser Gly 
                245                 250                 255     


Ser Thr Ala Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
            260                 265                 270         


Thr Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu 
        275                 280                 285             


Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys 
    290                 295                 300                 


Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
305                 310                 315                 320 


Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu 
                325                 330                 335     


Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg 
            340                 345                 350         


Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg 
        355                 360                 365             


Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln 
    370                 375                 380                 


Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly 
385                 390                 395                 400 


Arg Ala Asp Val Asn Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys 
                405                 410                 415     


Ile Glu Trp His Glu 
            420     


<210>  9
<211>  1251
<212>  DNA
<213>  Homo sapiens

<400>  9
atggagacag acacactcct gttatgggta ctgctgctct gggttccagg ttccaccggt       60

ggagattcag tgacccagat ggaagggcca gtgactctct cagaagaggc cttcctgact      120

ataaactgca cgtacacagc cacaggatac ccttcccttt tctggtatgt ccaatatcct      180

ggagaaggtc tacagctcct cctgaaagcc acgaaggctg atgacaaggg aagcaacaaa      240

ggttttgaag ccacataccg taaagaaacc acttctttcc acttggagaa aggctcagtt      300

caagtgtcag actcagcggt gtacttctgt gcttccgtct atgggaacaa cagactcgct      360

tttgggaagg ggaaccaagt ggtggtcata ccaactagtg gaggaggtgg gagcggaggt      420

ggtgctagcg gtggcggcgg ttctggcggt ggcggttcct caagcgatgt gaaagtaacc      480

cagagctcga gatatctagt caaaaggacg ggagagaaag tttttctgga atgtgtccag      540

gatatggacc atgaaaatat gttctggtat cgacaagacc caggtctggg gctacggctg      600

atctatttct catatgatgt taaaatgaaa gaaaaaggag atattcctga ggggtacagt      660

gtctctagag agaagaagga gcacttctcc ctgattctgg agtccgccag caccaaccag      720

acatctatgt acctctgtgc cagcagtttg ggctcgggga gcacagatac gcagtatttt      780

ggcccaggca cccggctgac agtgctcgag gacctgaaca aggtgttccc acccgaggtc      840

gctgtgtttg agccatcaga agcagagatc tcccacaccc aaaaggccac actggtgtgc      900

ctggccacag gcttcttccc tgaccacgtg gagctgagct ggtgggtgaa tgggaaggag      960

gtgcacagtg gggtcagcac ggacccgcag cccctcaagg agcagcccgc cctcaatgac     1020

tccagatact gcctgagcag ccgcctgagg gtctcggcca ccttctggca gaacccccgc     1080

aaccacttcc gctgtcaagt ccagttctac gggctctcgg agaatgacga gtggacccag     1140

gatagggcca aacccgtcac ccagatcgtc agcgccgagg cctggggtag agcagacgtt     1200

aacggtggtc tgaacgacat cttcgaagct cagaaaattg aatggcacga a              1251


<210>  10
<211>  417
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (47)..(52)
<223>  CDR1 V alpha

<220>
<221>  SITE
<222>  (70)..(76)
<223>  CDR2 V alpha

<220>
<221>  SITE
<222>  (111)..(120)
<223>  CDR3 V alpha

<220>
<221>  DOMAIN
<222>  (134)..(153)
<223>  Linker

<220>
<221>  SITE
<222>  (182)..(186)
<223>  CDR1 V beta

<220>
<221>  SITE
<222>  (204)..(209)
<223>  CDR2 V beta

<220>
<221>  SITE
<222>  (247)..(260)
<223>  CDR3 V beta

<220>
<221>  DOMAIN
<222>  (400)..(417)
<223>  BirA tag

<400>  10

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gly Asp Ser Val Thr Gln Met Glu Gly Pro Val Thr 
            20                  25                  30          


Leu Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr 
        35                  40                  45              


Gly Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu 
    50                  55                  60                  


Gln Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu 
                85                  90                  95      


Lys Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Val Tyr Gly Asn Asn Arg Leu Ala Phe Gly Lys Gly Asn Gln Val Val 
        115                 120                 125             


Val Ile Pro Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Asp Val Lys Val Thr 
145                 150                 155                 160 


Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly Glu Lys Val Phe Leu 
                165                 170                 175     


Glu Cys Val Gln Asp Met Asp His Glu Asn Met Phe Trp Tyr Arg Gln 
            180                 185                 190         


Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe Ser Tyr Asp Val Lys 
        195                 200                 205             


Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr Ser Val Ser Arg Glu 
    210                 215                 220                 


Lys Lys Glu His Phe Ser Leu Ile Leu Glu Ser Ala Ser Thr Asn Gln 
225                 230                 235                 240 


Thr Ser Met Tyr Leu Cys Ala Ser Ser Leu Gly Ser Gly Ser Thr Asp 
                245                 250                 255     


Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu 
            260                 265                 270         


Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala 
        275                 280                 285             


Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly 
    290                 295                 300                 


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
305                 310                 315                 320 


Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro 
                325                 330                 335     


Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
            340                 345                 350         


Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
        355                 360                 365             


Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys 
    370                 375                 380                 


Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Val 
385                 390                 395                 400 


Asn Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                405                 410                 415     


Glu 
    


<210>  11
<211>  1251
<212>  DNA
<213>  Homo sapiens

<400>  11
atggagacag acacactact gttatgggta ctgctgctct gggttccagg ttccaccggt       60

ggagagagtg tggggctgca tcttcctacc ctgagtgtcc aggagggtga caactctatt      120

atcaactgtg cttattcaaa cagcgcctca gactacttca tttggtacaa gcaagaatct      180

ggaaaaggtc ctcaattcat tatagacatt cgttcaaata tggacaaaag gcaaggccaa      240

agagtcaccg ttttattgaa taagacagtg aaacatctct ctctgcaaat tgcagctact      300

caacctggag actcagctgt ctacttttgt gcagagagcg ggtactatgg tcagaatttt      360

gtctttggtc ccggaaccag attgtcagtg ctgccgacta gtggaggagg tgggagcgga      420

ggtggtgcta gcggtggcgg cggctctggc ggtggcggtt cctcaagcga agcccaagtg      480

acccagaacc caagatacct catcacagtg actggaaaga agttgacagt gacttgttct      540

cagaatatga accatgagta tatgtcctgg tatcgacaag acccagggct gggcttaagg      600

cagatctact attcaatgaa tgttgaggtg actgataagg gagatgttcc tgaagggtac      660

aaagtctctc gaaaagagaa gaggaatttc cccctgatcc tggagtcgcc cagccccaac      720

cagacctctc tgtacttctg tgccagcaga cccggacagg gaggctacga gcagtacttc      780

gggccgggca ccaggctcac ggtcacagag gacctgaaaa acgtgttccc acccgaggtc      840

gctgtgtttg agccatcaga agcagagatc tcccacaccc aaaaggccac actggtgtgc      900

ctggccacag gcttcttccc tgaccacgtg gagctgagct ggtgggttaa cgggaaggag      960

gtgcacagtg gggtcagcac ggacccgcag cccctcaagg agcagcccgc cctcaatgac     1020

tccagatact gcctgagcag ccgcctgagg gtctcggcca ccttctggca gaacccccgc     1080

aaccacttcc gctgtcaagt ccagttctac gggctctcgg agaatgacga gtggacccag     1140

gatagggcca aacccgtcac ccagatcgtc agcgccgagg cctggggtag agcagacgtt     1200

aacggtggtc tgaacgacat cttcgaagct cagaaaattg aatggcacga a              1251


<210>  12
<211>  417
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (47)..(52)
<223>  CDR1 V alpha

<220>
<221>  SITE
<222>  (70)..(76)
<223>  CDR2 V alpha

<220>
<221>  SITE
<222>  (111)..(120)
<223>  CDR3 V alpha

<220>
<221>  DOMAIN
<222>  (135)..(154)
<223>  Linker

<220>
<221>  SITE
<222>  (183)..(187)
<223>  CDR1 V beta

<220>
<221>  SITE
<222>  (205)..(210)
<223>  CDR2 V beta

<220>
<221>  SITE
<222>  (248)..(260)
<223>  CDR3 V beta

<220>
<221>  DOMAIN
<222>  (400)..(417)
<223>  BirA tag

<400>  12

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Ser Gly Tyr Tyr Gly Gln Asn Phe Val Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Ser Val Leu Pro Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Glu Ala Gln Val 
145                 150                 155                 160 


Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly Lys Lys Leu Thr 
                165                 170                 175     


Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met Ser Trp Tyr Arg 
            180                 185                 190         


Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr Ser Met Asn Val 
        195                 200                 205             


Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr Lys Val Ser Arg 
    210                 215                 220                 


Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser Pro Ser Pro Asn 
225                 230                 235                 240 


Gln Thr Ser Leu Tyr Phe Cys Ala Ser Arg Pro Gly Gln Gly Gly Tyr 
                245                 250                 255     


Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr Glu Asp Leu 
            260                 265                 270         


Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala 
        275                 280                 285             


Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly 
    290                 295                 300                 


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
305                 310                 315                 320 


Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro 
                325                 330                 335     


Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
            340                 345                 350         


Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
        355                 360                 365             


Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys 
    370                 375                 380                 


Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Val 
385                 390                 395                 400 


Asn Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                405                 410                 415     


Glu 
    


<210>  13
<211>  1257
<212>  DNA
<213>  Homo sapiens

<400>  13
atggagacag acacactcct gttatgggta ctgctgctct gggttccagg ttccaccggt       60

gcccagaaga taactcaaac ccaaccagga atgttcgtgc aggaaaagga ggctgtgact      120

ctggactgca catatgacac cagtgatcaa agttatggtc tattctggta caagcagccc      180

agcagtgggg aaatgatttt tcttatttat caggggtctt atgacgagca aaatgcaaca      240

gaaggtcgct actcattgaa tttccagaag gcaagaaaat ccgccaacct tgtcatctcc      300

gcttcacaac tgggggactc agcaatgtat ttctgtgcaa tgagagatgg cggaacctcc      360

tacgacaagg tgatatttgg gccagggaca agcttatcag tcattccaac tagtggagga      420

ggtgggagcg gaggtggtgc tagcggtggc ggcggttctg gcggtggcgg ttcctcaagc      480

gaagcccaag tgacccagaa cccaagatac ctcatcacag tgactggaaa gaagttaaca      540

gtgacttgtt ctcagaatat gaaccatgag tatatgtcct ggtatcgaca agacccaggg      600

ctgggcttaa ggcagatcta ctattcaatg aatgttgagg tgactgataa gggagatgtt      660

cctgaagggt acaaagtctc tcgaaaagag aagaggaatt tccccctgat cctggagtcg      720

cccagcccca accagacctc tctgtacttc tgtgccagca gcggtcatat ggatacgcag      780

tattttggcc caggcacccg gctgacagtg ctcgaggacc tgaacaaggt gttcccaccc      840

gaggtcgctg tgtttgagcc atcagaagca gagatctccc acacccaaaa ggccacactg      900

gtgtgcctgg ccacaggctt cttccctgac cacgtggagc tgagctggtg ggtgaatggg      960

aaggaggtgc acagtggggt cagcacggac ccgcagcccc tcaaggagca gcccgccctc     1020

aatgactcca gatactgcct gagcagccgc ctgagggtct cggccacctt ctggcagaac     1080

ccccgcaacc acttccgctg tcaagtccag ttctacgggc tctcggagaa tgacgagtgg     1140

acccaggata gggccaaacc cgtcacccag atcgtcagcg ccgaggcctg gggtagagca     1200

gacgttaacg gtggtctgaa cgacatcttc gaagctcaga aaattgaatg gcacgaa        1257


<210>  14
<211>  419
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (47)..(53)
<223>  CDR1 V alpha

<220>
<221>  SITE
<222>  (71)..(78)
<223>  CDR2 V alpha

<220>
<221>  SITE
<222>  (113)..(125)
<223>  CDR3 V alpha

<220>
<221>  DOMAIN
<222>  (139)..(158)
<223>  Linker

<220>
<221>  SITE
<222>  (187)..(191)
<223>  CDR1 V beta

<220>
<221>  SITE
<222>  (209)..(214)
<223>  CDR2 V beta

<220>
<221>  SITE
<222>  (252)..(261)
<223>  CDR3 V beta

<220>
<221>  DOMAIN
<222>  (402)..(419)
<223>  BirA tag

<400>  14

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Gln Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Arg Asp Gly Gly Thr Ser Tyr Asp Lys Val Ile Phe Gly Pro 
        115                 120                 125             


Gly Thr Ser Leu Ser Val Ile Pro Thr Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser 
145                 150                 155                 160 


Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly 
                165                 170                 175     


Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met 
            180                 185                 190         


Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr 
        195                 200                 205             


Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr 
    210                 215                 220                 


Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser 
225                 230                 235                 240 


Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Ser Gly His 
                245                 250                 255     


Met Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu 
            260                 265                 270         


Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
        275                 280                 285             


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
    290                 295                 300                 


Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
305                 310                 315                 320 


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
                325                 330                 335     


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
            340                 345                 350         


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
        355                 360                 365             


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
    370                 375                 380                 


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
385                 390                 395                 400 


Asp Val Asn Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
                405                 410                 415     


Trp His Glu 
            


<210>  15
<211>  1254
<212>  DNA
<213>  Homo sapiens

<400>  15
atggagacag acacactcct gttatgggta ctgctgctct gggttccagg ttccaccggt       60

atactgatca agcaatgctg gtgtcactca gaccccaaaa ttccgcatcc tgaagatagg      120

acagagcatg acactgcagt gtacccagga tatgaaccat aactacatgt actggtatcg      180

acaagaccca ggcatggggc tgaagctgat ttattattca gttggtgctg gtatcactga      240

taaaggagaa gtcccgaatg gctacaacgt ctccagatca accacagagg attttccgct      300

caggctggag ttggctgctc cctcccagac atctgtgtac ttctgtgcca gcacccgggg      360

ccgaggtggg acccagtact tcgggccagg cacgcggctc ctggtgctcg aggacctgaa      420

caaggtgttc ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac      480

ccaaaaggcc acactggtgt gcctggccac aggcttcttc cctgaccacg tggagctgag      540

ctggtgggtg aatgggaagg aggtgcacag tggggtcagc acggacccgc agcccctcaa      600

ggagcagccc gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc      660

caccttctgg cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc      720

ggagaatgac gagtggaccc aggatagggc caaacccgtc acccagatcg tcagcgccga      780

ggcctggggt agagcagaca cgtggaacaa agtcctcagt cactgcatgt tcaggaggga      840

gacagcacca atttcacctg cagcttccct tccagcaatt tttatgcctt acactggtac      900

agatgggaaa ctgcaaaaag ccccgaggcc ttgtttgtaa tgactttaaa tggggatgaa      960

aagaagaaag gacgaataag tgccactctt aataccaagg agggttacag ctatttgtac     1020

atcaaaggat cccagcctga agactcagcc acatacctct gtgcctcctg ggataactat     1080

ggtcagaatt ttgtctttgg tcccggaacc agattgtccg tgctgcccac tagtggagga     1140

ggaggaagcg gaggtggtgc tagcggtggc ggcggttctg gcggtggcgg ttccgttaac     1200

atcgatggcg gtctgaacga catcttcgaa gctcagaaaa tagaatggca cgaa           1254


<210>  16
<211>  418
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (47)..(52)
<223>  CDR1 V alpha

<220>
<221>  SITE
<222>  (70)..(76)
<223>  CDR2 V alpha

<220>
<221>  SITE
<222>  (111)..(121)
<223>  CDR3 V alpha

<220>
<221>  DOMAIN
<222>  (135)..(154)
<223>  Linker

<220>
<221>  SITE
<222>  (183)..(187)
<223>  CDR1 V beta

<220>
<221>  SITE
<222>  (205)..(210)
<223>  CDR2 V beta

<220>
<221>  SITE
<222>  (248)..(258)
<223>  CDR3 V beta

<220>
<221>  DOMAIN
<222>  (399)..(418)
<223>  BirA tag

<400>  16

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu His 
            20                  25                  30          


Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser Ser 
        35                  40                  45              


Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys Ser Pro 
    50                  55                  60                  


Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys Lys Gly 
65                  70                  75                  80  


Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu Tyr 
                85                  90                  95      


Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Ser 
            100                 105                 110         


Trp Asp Asn Tyr Gly Gln Asn Phe Val Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Ser Val Leu Pro Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Asn Ala Gly Val 
145                 150                 155                 160 


Thr Gln Thr Pro Lys Phe Arg Ile Leu Lys Ile Gly Gln Ser Met Thr 
                165                 170                 175     


Leu Gln Cys Thr Gln Asp Met Asn His Asn Tyr Met Tyr Trp Tyr Arg 
            180                 185                 190         


Gln Asp Pro Gly Met Gly Leu Lys Leu Ile Tyr Tyr Ser Val Gly Ala 
        195                 200                 205             


Gly Ile Thr Asp Lys Gly Glu Val Pro Asn Gly Tyr Asn Val Ser Arg 
    210                 215                 220                 


Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Glu Leu Ala Ala Pro Ser 
225                 230                 235                 240 


Gln Thr Ser Val Tyr Phe Cys Ala Ser Thr Arg Gly Arg Gly Gly Thr 
                245                 250                 255     


Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Asn 
            260                 265                 270         


Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu 
        275                 280                 285             


Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe 
    290                 295                 300                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
305                 310                 315                 320 


His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala 
                325                 330                 335     


Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            340                 345                 350         


Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        355                 360                 365             


Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
    370                 375                 380                 


Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Val Asn 
385                 390                 395                 400 


Ile Asp Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp 
                405                 410                 415     


His Glu 
        


<210>  17
<211>  1266
<212>  DNA
<213>  Homo sapiens

<400>  17
atggagacag acacactcct gttatgggta ctgctgctct gggttccagg ttccaccggt       60

gagctgaaag tggaacaaaa ccctctgttc ctgagcatgc aggagggaaa aaactatacc      120

atctactgca attattcaac cacttcagac agactgtatt ggtacaggca ggatcctggg      180

aaaagtctgg aatctctgtt tgtgttgcta tcaaatggag cagtgaagca ggagggacga      240

ttaatggcct cacttgatac caaagcccgt ctcagcaccc tccacatcac agctgccgtg      300

catgacctct ctgccaccta cttctgtgcc gtggacgaag ggtggggagc ccagaagctg      360

gtatttggcc aaggaaccag gctgactatc aatccgacta gtggaggagg tgggagcgga      420

ggtggtgcta gcggtggcgg cggttctggc ggtggcggtt cctcaagcga cactgaagtt      480

acccagacac caaaacacct ggtcatggga atgacaaata agaagtcttt gaaatgtgaa      540

caacatatgg ggcacagggc tatgtattgg tacaagcaga aagctaagaa gccaccggag      600

ctcatgtttg tctacagcta tgagaaactc tctataaatg aaagtgtgcc aagtcgcttc      660

tcacctgaat gccccaacag ctctctctta aaccttcacc tacacgccct gcagccagaa      720

gactcagccc tgtatctctg cgccagcagc catcctttta gcggatctag cacagatacg      780

cagtattttg gcccaggcac ccggctgaca gtgctcgagg acctgaaaaa cgtgttccca      840

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      900

ctggtgtgcc tggccacagg cttcttccct gaccacgtgg agctgagctg gtgggtgaat      960

gggaaggagg tgcacagtgg ggtcagcacg gacccgcagc ccctcaagga gcagcccgcc     1020

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag     1080

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag     1140

tggacccagg atagggccaa acccgtcacc cagatcgtca gcgccgaggc ctggggtaga     1200

gcagacgtta acatcgatgg cggtctgaac gacatcttcg aagctcagaa aatagaatgg     1260

cacgaa                                                                1266


<210>  18
<211>  422
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(20)

<220>
<221>  SITE
<222>  (47)..(51)
<223>  CDR1 V alpha

<220>
<221>  SITE
<222>  (69)..(75)
<223>  CDR2 V alpha

<220>
<221>  SITE
<222>  (110)..(121)
<223>  CDR3 V alpha

<220>
<221>  DOMAIN
<222>  (135)..(154)
<223>  Linker

<220>
<221>  SITE
<222>  (183)..(187)
<223>  CDR1 V beta

<220>
<221>  SITE
<222>  (205)..(210)
<223>  CDR2 V beta

<220>
<221>  SITE
<222>  (248)..(262)
<223>  CDR3 V beta

<220>
<221>  DOMAIN
<222>  (403)..(422)
<223>  BirA tag

<400>  18

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser 
            20                  25                  30          


Met Gln Glu Gly Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr 
        35                  40                  45              


Ser Asp Arg Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu 
    50                  55                  60                  


Ser Leu Phe Val Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg 
65                  70                  75                  80  


Leu Met Ala Ser Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile 
                85                  90                  95      


Thr Ala Ala Val His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Val Asp 
            100                 105                 110         


Glu Gly Trp Gly Ala Gln Lys Leu Val Phe Gly Gln Gly Thr Arg Leu 
        115                 120                 125             


Thr Ile Asn Pro Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ser Asp Thr Glu Val 
145                 150                 155                 160 


Thr Gln Thr Pro Lys His Leu Val Met Gly Met Thr Asn Lys Lys Ser 
                165                 170                 175     


Leu Lys Cys Glu Gln His Met Gly His Arg Ala Met Tyr Trp Tyr Lys 
            180                 185                 190         


Gln Lys Ala Lys Lys Pro Pro Glu Leu Met Phe Val Tyr Ser Tyr Glu 
        195                 200                 205             


Lys Leu Ser Ile Asn Glu Ser Val Pro Ser Arg Phe Ser Pro Glu Cys 
    210                 215                 220                 


Pro Asn Ser Ser Leu Leu Asn Leu His Leu His Ala Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser His Pro Phe Ser Gly Ser 
                245                 250                 255     


Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            260                 265                 270         


Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
        275                 280                 285             


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
    290                 295                 300                 


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
305                 310                 315                 320 


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
                325                 330                 335     


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
            340                 345                 350         


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
        355                 360                 365             


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
    370                 375                 380                 


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
385                 390                 395                 400 


Ala Asp Val Asn Ile Asp Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln 
                405                 410                 415     


Lys Ile Glu Trp His Glu 
            420         


<210>  19
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  19

Arg Leu Arg Pro Gly Gly Lys Lys Lys 
1               5                   


<210>  20
<211>  10
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  20

Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe 
1               5                   10  


<210>  21
<211>  8
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  21

Glu Ile Tyr Lys Arg Trp Ile Ile 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  22

Phe Leu Lys Glu Lys Gly Gly Leu 
1               5               


<210>  23
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  23

Asp Arg Phe Tyr Lys Thr Leu Arg Ala 
1               5                   


<210>  24
<211>  10
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  24

Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 
1               5                   10  


<210>  25
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  25

Arg Pro Gln Val Pro Leu Arg Pro Met Thr Tyr 
1               5                   10      


<210>  26
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  26

Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe 
1               5                   10      


<210>  27
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  27

Ile Ser Pro Arg Thr Leu Asn Ala Trp 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus type 1

<400>  28

Gln Ala Ser Gln Glu Val Lys Asn Trp 
1               5                   


