                         SEQUENCE LISTING

<110>  President and Fellows of Harvard College
 
<120>  METHODS AND COMPOSITIONS FOR RESTORING STMN2 LEVELS

<130>  HRVY-135-WO1

<140>  PCT/US2020/013581
<141>  2020-01-14

<150>  US 62/792,276
<151>  2019-01-14

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  592
<212>  DNA
<213>  Homo sapiens

<400>  1
agctcctagg aagcttcagg gcttaaagct ccactctact tggactgtac tatcaggccc       60

ccaaaatggg gggagccgac agggaaggac tgatttccat ttcaaactgc attctggtac      120

tttgtactcc agcaccattg gccgatcaat atttaatgct tggagattct gactctgcgg      180

gagtcatgtc aggggacctt gggagccaat ctgcttgagc ttctgagtga taattattca      240

tgggctcctg cctcttgctc tttctctagc acggtcccac tctgcagact cagtgcctta      300

ttcagtcttc tctctcgctc tctccgctgc tgtagccgga ccctttgcct tcgccactgc      360

tcagcgtctg cacatcccta caatggctaa aacagcaatg ggactcggca gaagaccttc      420

gagagaaagg tagaaaataa gaatttggct ctctgtgtga gcatgtgtgc gtgtgtgcga      480

gagagagaga cagacagcct gcctaagaag aaatgaatgt gaatgcggct tgtggcacag      540

ttgacaagga tgataaatca ataatgcaag cttactatca tttatgaata gc              592


<210>  2
<211>  97
<212>  DNA
<213>  Homo sapiens

<400>  2
cctacaagga aaaaatgaag gagctgtcca tgctgtcact gatctgctct tgcttttacc       60

cggaacctcg caacatcaac atctatactt acgatgg                                97


<210>  3
<211>  191
<212>  DNA
<213>  Homo sapiens

<400>  3
gactcggcag aagaccttcg agagaaaggt agaaaataag aatttggctc tctgtgtgag       60

catgtgtgcg tgtgtgcgag agagagagac agacagcctg cctaagaaga aatgaatgtg      120

aatgcggctt gtggcacagt tgacaaggat gataaatcaa taatgcaagc ttactatcat      180

ttatgaatag c                                                           191


<210>  4
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  gRNA

<400>  4
caccgtatag atgttgatgt tgcg                                              24


<210>  5
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  gRNA

<400>  5
cacctgaaac aattggcaga gaag                                              24


<210>  6
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  gRNA

<400>  6
caccagtcct tcagaaggct ttgg                                              24


<210>  7
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  7
gcaaaggagt ctacctggca                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  8
ggaagggtga ctgactgctc                                                   20


<210>  9
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  modified STMN2

<400>  9
atggctaaaa cagcaatggg actcggcaga agaccttcga gagaaaggta g                51


<210>  10
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  modified STMN2

<400>  10

Met Ala Lys Thr Ala Met Gly Leu Gly Arg Arg Pro Ser Arg Glu Arg 
1               5                   10                  15      


<210>  11
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  antisense oligonucleotide

<400>  11
tcttcagtat tgctattcat                                                   20


<210>  12
<211>  500
<212>  DNA
<213>  Artificial

<220>
<223>  STMN2/modified STMN2


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is a, c, g, or t

<400>  12
nnnnnnnnnn tccngangan gctgattctg accactaaac acatcagttt tagggatatt       60

aacttgtaat atacaggtat ccctcctggt aagctctggt attatgtctt aacattttta      120

aatctatggt aatctttaca aaatatttta cttccgaact catatacctg gggattttat      180

tactctggga attatgtgtt ctgccccatc actctctctt aattggattt ttaaaattat      240

attcatattg caggactcgg cagaagacct tcgagagaaa ggtagaaaat aagaatttgg      300

ctctctgtgt gagcatgtgt gcgtgtgtgc gagagagaga gacagacagc ctgcctaaga      360

agaaatgaat gtgaatgcgg cttgtggcac agttgacaag gatgataaat caataatgca      420

agcttactat catttatgaa tagcaatact gaagaaatta aaacaaaaga ttgctgtctc      480

aatatatctt atatttatta                                                  500


<210>  13
<211>  392
<212>  DNA
<213>  Artificial

<220>
<223>  STMN2/modified STMN2


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is a, c, g, or t

<400>  13
nnnnnnnctc ngangangct gattctgacc actaaacaca tcagttttag ggatattaac       60

ttgtaatata caggtatccc tcctggtaag ctctggtatt atgtcttaac atttttaaat      120

ctatggtaat ctttacaaaa tattttactt ccgaactcat atacctgggg attttattac      180

tctgggaatt atgtgttctg ccccatcact ctctcttaat tggattttta aaattatatt      240

catattgcag gactcggcag aagaccttcg agattgtggc acagttgaca aggatgataa      300

atcaataatg caagcttact atcatttatg aatagcaata ctgaagaaat taaaacaaaa      360

gattgctgtc tcaatatatc ttatatttat ta                                    392


<210>  14
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  gRNA

<400>  14
cgcaacatca acatctacac                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  gRNA

<400>  15
cgagcgagag gtgctccaga                                                   20


<210>  16
<211>  262
<212>  DNA
<213>  Homo sapiens

<400>  16
tctctcttaa ttggattttt aaaattatat tcatattgca ggactcggca gaagaccttc       60

gagagaaagg tagaaaataa gaatttggct ctctgtgtga gcatgtgtgc gtgtgtgcga      120

gagagagaga cagacagcct gcctaagaag aaatgaatgt gaatgcggct tgtggcacag      180

ttgacaagga tgataaatca ataatgcaag cttactatca tttatgaata gcaatactga      240

agaaattaaa acaaaagatt gc                                               262


<210>  17
<211>  262
<212>  DNA
<213>  Homo sapiens

<400>  17
tctctcttaa ttggattttt aaaattatat tcatattgca ggactcggca gaagaccttc       60

gagagaaagg tagaaaataa gaatttggct ctctgtgtga gcatgtgtgc gtgtgtgcga      120

gagagagaga cagacagcct gcctaagaag aaatgaatgt gaatgcggct tgtggcacag      180

ttgacaagga tgataaatca ataatgcaag cttactatca tttatgaata gcaatactga      240

agaaattaaa acaaaagatt gc                                               262


<210>  18
<211>  258
<212>  DNA
<213>  Chimp

<400>  18
tctctcctaa ttggattttt aaaattatat tcatattgca ggactcagca gaagaccttc       60

gagagaaagg tagaaaataa gaatttggct ctctgtgtga gcatgtgtgc atgtgtgcga      120

gagagagaga cagtctgcct aagaagaaat gaatgtgaat gcggcttgtg gcacagttga      180

caaggatgat aaatcaataa tgcaagctta ctattattta tgaatagcaa tactgaagaa      240

attaaaacaa aagattgc                                                    258


<210>  19
<211>  260
<212>  DNA
<213>  Gorilla

<400>  19
tctctcttaa ttggattttt aaaattatat tcatattgca ggactcagca gaagaccttc       60

gagagaaagg tagaaaataa gaatttggct ctctgtgtga gcatgtgtgc gtgtgtgcga      120

gagagagaga gacggtctgc ctaagaagaa atgaatgtga atgcagcttg tggcacagtt      180

gacaaggatg ataaatcagt aatgcaagct tactattatt tatgaatagc aatactgaag      240

aaattaaaac aaaagattgc                                                  260


<210>  20
<211>  260
<212>  DNA
<213>  Orangutan

<400>  20
tctctcttaa ttggattttt taaattatat tcatattgca ggactcagca gaagaccttc       60

gagagaaagg tagaaaataa gaatttggct ctctgtgtga gcatgtgtgc atgtgtgaga      120

gagagagaga gagagtctgc ctaagaagaa atgaatgtga atgcggcttg tggcacagtt      180

gacaaggatg ataaatcaat aatgcaagct tactattatt tatgaacagc aatactgaag      240

aaattaaaac aaaagattgc                                                  260


<210>  21
<211>  262
<212>  DNA
<213>  Gibbon

<400>  21
tctctcttaa ttggattttt taaattatat tcatattgca ggactcggca gaagaccttc       60

gagagaaagg tagaaaataa gaatttggct ctctgtgtga gcatgtgtgt gtgtgtgcga      120

gagagagaga aagagagtct gcctaagaag aaatgaatgt gaatgcggct tgtggcacag      180

ttaacaagga tgataaatca ataatgcaag cttactatta tttatgaata gcaatactga      240

agaaattaaa acaaaagatt gc                                               262


<210>  22
<211>  258
<212>  DNA
<213>  Rhesus

<400>  22
tctctcttaa ttggattttt aaaattatat tcatattgca ggactcagca gaagaccttc       60

gagataaagg tagaaaataa gaatctggtt ctctgtgtga gcatgtgaga gagagagaga      120

gagagagaga aagtctgcct aagaagaaat gaatgtgaat gcgccttgtg ggacagttga      180

caagaatgat aaatcaataa tacaagttta ctattattta tgaatagcaa tactgaagaa      240

attaaaacaa aagattgc                                                    258


<210>  23
<211>  256
<212>  DNA
<213>  Crab-eating macaque

<400>  23
tctctcttaa ttggattttt aaaattatat tcatattgca ggactcagca gaagaccttc       60

gagataaagg tagaaaataa gaatctggtt ctctgtgtga gcatgtgaga gagagagaga      120

gagagagaaa gtctgcctaa gaagaaatga atgtgaatgc gccttgtggg acagttgaca      180

agaatgataa atcaataatg caagtttact attatttatg aatagcaata ctgaagaaat      240

taaaacaaaa gattgc                                                      256


<210>  24
<211>  260
<212>  DNA
<213>  Baboon

<400>  24
tctctcttaa ttggattttt aaaattatat tcatattgca ggactcagca gaagaccttc       60

gagagaaagg tagaaaataa gaatttggct ctctgtgtga gcatgtgaga gagagaaaga      120

gagagagaaa gaaagtctgc ctaagaagaa atgaatgtga atgcgccttg tgggacagtt      180

gacaaggatg ataaatcaat aatgcaagtt tactattatt tatgaatagc aatactgaag      240

aaattaaaac aaaagattgc                                                  260


<210>  25
<211>  260
<212>  DNA
<213>  Green monkey

<400>  25
tctctcttaa ttggattttt aaaattatat tcatattgca ggactcagca gaagaccttc       60

gagagaaagg tagaaaataa gaatttggct ttctgtgtga gcatgtgaga gagagagaga      120

gagagagaga gaaagtctgc ctaagaagaa atgaatgtga atgcgccttg tgggacagtt      180

gacaagaatg ataaatcaat aatgcaagct tactattatt tatgaatagc aatactgaag      240

aaattaaaac aaaagactgc                                                  260


<210>  26
<211>  259
<212>  DNA
<213>  Marmoset

<400>  26
tctctcttaa ttagattttt taaattatat tcatattgca ggattcagca gaagacctcc       60

aagagaaatg tagaagataa gaatttggct ctctgtgtga tcgtgtgaga gagagagaga      120

gagagagaga gagagtctgc ctaagaaaaa atgaatgtga atgcagcttg tggcacagtt      180

gacaagatag taaatcaata atgcaagctt attattattt aaaaacagtg atactgaaga      240

aatttaaaca aaagactgc                                                   259


<210>  27
<211>  256
<212>  DNA
<213>  Squirrel monkey

<400>  27
tctctcttaa ttggattttt aaaattatat ttatattgca ggattcagca gaagaccttc       60

aagagaaatg tagaaaataa gaatttggct ctctgtgtga tcgtgtgaga gagagagaga      120

gagagagaga gagagtctgc ctaagaagaa atgaatgtga atgcagcttg tggcacagct      180

gacaaggata ataaatcaat aatgtaagcg tactattatt tgaaaacagt gtgaagaaat      240

ttaaacaaaa gactgc                                                      256


<210>  28
<211>  210
<212>  DNA
<213>  Bushbaby

<400>  28
tctcccttaa ttggattttc aaaattatat tcaaatttca gaactcagca gaagaccttc       60

aagagaaatg taaaaaatga gaatttgact ctgtctgaga tgtgtgcata tatgtgtgac      120

tatctaagaa gaaataagga tgataaatca ataatgccag cttcctgtcc ctaataaaca      180

ataatactga ggaaattaaa acaggattat                                       210


<210>  29
<211>  219
<212>  DNA
<213>  Mouse

<400>  29
tctctcttaa ttagattgtt taaaatatat ttatattaca ggactcaaca gaaggccttt       60

gaggaaaagg tgggaaataa gcctggctct gtgaatatgt gtgtgggtgg gtgggtctgt      120

agaagaaaat atccagaaaa attgttaaaa gggataatat ataatatgat attactgtca      180

cttacaaatg ataatataac aggttaaaat cagaagtta                             219


<210>  30
<211>  156
<212>  DNA
<213>  Rat

<400>  30
ctctcttaat tagattgttt aaaatatatt tatattacag gactcaacag aagacctttg       60

gggaaaatgt gggaaataag actggctctg tccatgtgtg tgggtaggtg ggtctgtata      120

atgcacaatt atataacagg ttaaaaccag aagtca                                156


<210>  31
<211>  201
<212>  DNA
<213>  Pika

<400>  31
tcctcttaat tggattttaa aaaatatatt catgttacag gactcagcag acctccaaga       60

gaattatgga atgtgtgtct ctttgtcttg cctaagaaga agaaatggat gtggctgtgg      120

tacagaaaag gaataaatca atcatgccag cttcccgtta tttacaaaca ggattttgag      180

aaaattaaga ttgaaaatta t                                                201


<210>  32
<211>  221
<212>  DNA
<213>  Dolphin

<400>  32
tctcttttaa ttggattttt aaaatatatt catattgcag gattcagcaa aagaccttca       60

agagaaatgt gtaaataaga atttgactct gtttgggtgg gggggtgtgt gtaagaaaaa      120

aatgaatgtg gcttgcagca cagttgagaa ggacgataaa tcaatactgc tagtttactg      180

tcgtttacaa taatactaag gaaattaaca cagaggattg c                          221


<210>  33
<211>  194
<212>  DNA
<213>  Cow

<400>  33
tctcttttaa atggactttt aaaatatatt cgtattgcag gactcagcag aagaccttca       60

ggagaatgtg gaaataagaa tttgtgcatg tgtatgtgcc tgtgtgtgta tgagaacaga      120

atgtaacctg cagtacaatt cagaaccttt acttgtggaa tgttaacact aaagaaatta      180

acaaggagga tctc                                                        194


<210>  34
<211>  212
<212>  DNA
<213>  Panda

<400>  34
tctctcttaa ttggattttt aaaaatatat tcatattgta ggactcagca gaagaccttc       60

aaagaaatgt gaagagtgag gatttggctg tgtgtgtgtg tgtctgtctg tctgtctaag      120

aaaaaatgaa tatggcttgt ggcacagtcg agaaagatga tacactagct tactgttatt      180

tacaaaatac tgtagaaact aaaacagatt ac                                    212


<210>  35
<211>  195
<212>  DNA
<213>  Elephant

<400>  35
actttgttaa tggcattttt aaaaatatat tcatattgca agactcggca gaagaccttt       60

gagcatgata tgaaaatgag aatttggctc tgtgtgtgta agaagaaatg aatatggtta      120

gttgagaaga atgataaatc agtaatgctt gcctactgtt gtttacaaca aaaaggaatt      180

aaaacgagaa gttgc                                                       195


<210>  36
<211>  215
<212>  DNA
<213>  Opossum

<400>  36
cccctttctg agaaaggatt ttctaagaat gatgcaacag aaatccctca ataaggagac       60

agaaaatgaa aacttgggtt tctgtatcct agagagtttt tgtcagtgca aaggagatga      120

ctatgcattg tgtagactct attggtcatt gtatatgaag aactcagact tcagaacttt      180

agaataatcc tcagagaatt aagacaaaga gttgc                                 215


