                         SEQUENCE LISTING

<110>  Ask Gene
       Ask Gene
       Shanebeck, Kurt
 
<120>  PD-L1 Specific Monoclonal Antibodies for Disease Treatment and 
       Diagnosis

<130>  AG3-017USP1

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Variable Domain, mouse antibody

<400>  1

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Ala Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Ser Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Arg Leu Asp Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Leu Asp Trp Asp Val Gly Tyr Phe Asp Val Trp Gly Ala Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  2
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Variable Domain, mouse antibody

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ile Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  3
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Variable Domain, mouse antibody

<400>  3

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ile Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Ser Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  4
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HC Variable Domain, mouse antibody

<400>  4

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Ala Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Ser Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Thr Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Arg Leu Asp Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Pro Asp Trp Asp Val Gly Tyr Phe Asp Val Trp Gly Ala Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  5
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Variable Domain, mouse antibody

<400>  5

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Lys Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asn Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Gly Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  6
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LC Variable Domain, mouse antibody

<400>  6

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR for Clone M1, mouse antibody

<400>  7

Gly Tyr Ser Ile Thr Ser Asp Tyr Trp Asn 
1               5                   10  


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR for Clone M1, mouse antibody

<400>  8

Ser Tyr Thr Gly Ser 
1               5   


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR for Clone M1, mouse antibody

<400>  9

Tyr Leu Asp Trp Asp Val Gly Tyr Phe Asp Val 
1               5                   10      


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR for Clone M1, mouse antibody

<400>  10

Lys Ser Ser Gln Ser Leu Leu Lys Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR for Clone M1, mouse antibody

<400>  11

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR for Clone M1, mouse antibody

<400>  12

Gln Gln Tyr Tyr Gly Tyr Pro Phe Thr 
1               5                   


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR for Clone M2, mouse antibody

<400>  13

Gly Phe Asn Ile Lys Asp Asp Tyr Leu His 
1               5                   10  


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR for Clone M2, mouse antibody

<400>  14

Asp Pro Ala Asn Gly Asn 
1               5       


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR for Clone M2, mouse antibody

<400>  15

Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
1               5                   10              


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR for Clone M2, mouse antibody

<400>  16

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR for Clone M2, mouse antibody

<400>  17

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR for Clone M2, mouse antibody

<400>  18

Gln Gln Gly Lys Thr Leu Pro Pro Thr 
1               5                   


<210>  19
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR for Clone M4, mouse antibody

<400>  19

Phe Gly Tyr Ser Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
1               5                   10              


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR for Clone M5, mouse antibody

<400>  20

Tyr Pro Asp Trp Asp Val Gly Tyr Phe Asp Val 
1               5                   10      


<210>  21
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 variable domain

<400>  21

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  22
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 variable domain

<400>  22

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  23
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 variable domain

<400>  23

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  24
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 variable domain

<400>  24

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Glu Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  25
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 variable domain

<400>  25

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Glu Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  26
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 variable domain

<400>  26

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Glu Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 variable domain

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Lys Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  28
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 variable domain

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Lys Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  29
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 variable domain

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  30
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 variable domain

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  31
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PD-L1 antibody

<400>  31

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  32
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PD-L1 antibody

<400>  32

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  33
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PD-L1 antibody

<400>  33

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    450                 455                 460                 


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
465                 470                 475                 480 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                485                 490                 495     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            500                 505                 510         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        515                 520                 525             


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
    530                 535                 540                 


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
545                 550                 555                 560 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                565                 570                 575     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            580                 585                 590         


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
        595                 600                 605             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    610                 615                 620                 


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
625                 630                 635                 640 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                645                 650                 655     


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            660                 665                 670         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
        675                 680                 685             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    690                 695                 700                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
705                 710                 715                 720 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                725                 730                 735     


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
            740                 745                 750         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        755                 760                 765             


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    770                 775             


<210>  34
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PD-L1 antibody

<400>  34

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Glu Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  35
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PD-L1 antibody

<400>  35

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Glu Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  36
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PD-L1 antibody

<400>  36

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Glu Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  37
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PD-L1 antibody

<400>  37

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Glu Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  38
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PD-L1 antibody

<400>  38

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Glu Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  39
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PD-L1 antibody

<400>  39

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Glu Asp 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Phe Gly Tyr Phe Tyr Gly Ser Ser Phe Tyr Ala Val Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  40
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PD-L1 antibody

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Lys Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  41
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PD-L1 antibody

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Lys Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  42
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PD-L1 antibody

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  43
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized PD-L1 antibody

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  44
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 antibody

<400>  44

Ala Thr Gly Gly Ala Cys Ala Thr Gly Ala Gly Ala Gly Thr Gly Cys 
1               5                   10                  15      


Thr Gly Gly Cys Cys Cys Ala Ala Cys Thr Gly Cys Thr Gly Gly Gly 
            20                  25                  30          


Ala Cys Thr Gly Cys Thr Gly Cys Thr Gly Cys Thr Thr Thr Gly Thr 
        35                  40                  45              


Thr Thr Cys Cys Cys Thr Gly Gly Cys Gly Cys Thr Ala Gly Ala Thr 
    50                  55                  60                  


Gly Cys Gly Ala Cys Ala Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys 
65                  70                  75                  80  


Ala Cys Ala Gly Ala Gly Cys Cys Cys Cys Ala Gly Cys Ala Gly Cys 
                85                  90                  95      


Cys Thr Gly Thr Cys Thr Gly Cys Cys Thr Cys Thr Gly Thr Gly Gly 
            100                 105                 110         


Gly Ala Gly Ala Cys Ala Gly Ala Gly Thr Gly Ala Cys Cys Ala Thr 
        115                 120                 125             


Cys Ala Cys Cys Thr Gly Thr Ala Gly Ala Gly Cys Cys Ala Gly Cys 
    130                 135                 140                 


Cys Ala Gly Gly Ala Cys Ala Thr Cys Ala Gly Cys Ala Ala Cys Thr 
145                 150                 155                 160 


Ala Cys Cys Thr Gly Ala Ala Cys Thr Gly Gly Thr Ala Thr Cys Ala 
                165                 170                 175     


Gly Cys Ala Gly Ala Ala Ala Cys Cys Cys Gly Ala Cys Gly Gly Cys 
            180                 185                 190         


Ala Cys Cys Gly Thr Gly Ala Ala Gly Cys Thr Gly Cys Thr Gly Ala 
        195                 200                 205             


Thr Cys Thr Ala Cys Thr Ala Cys Ala Cys Cys Ala Gly Cys Ala Gly 
    210                 215                 220                 


Ala Cys Thr Gly Cys Ala Cys Ala Gly Cys Gly Gly Cys Gly Thr Gly 
225                 230                 235                 240 


Cys Cys Cys Ala Gly Cys Ala Gly Ala Thr Thr Thr Thr Cys Thr Gly 
                245                 250                 255     


Gly Cys Thr Cys Thr Gly Gly Cys Ala Gly Cys Gly Gly Cys Ala Cys 
            260                 265                 270         


Cys Gly Ala Cys Thr Thr Cys Ala Cys Cys Cys Thr Gly Ala Cys Cys 
        275                 280                 285             


Ala Thr Ala Thr Cys Thr Ala Gly Cys Cys Thr Gly Cys Ala Gly Cys 
    290                 295                 300                 


Cys Thr Gly Ala Gly Gly Ala Thr Ala Thr Cys Gly Cys Cys Ala Cys 
305                 310                 315                 320 


Cys Thr Ala Cys Thr Ala Cys Thr Gly Cys Cys Ala Gly Cys Ala Gly 
                325                 330                 335     


Gly Gly Cys Ala Ala Gly Ala Cys Cys Cys Thr Gly Cys Cys Thr Cys 
            340                 345                 350         


Cys Thr Ala Cys Ala Thr Thr Thr Gly Gly Cys Gly Gly Cys Gly Gly 
        355                 360                 365             


Ala Ala Cys Ala Ala Ala Gly Cys Thr Gly Gly Ala Ala Ala Thr Cys 
    370                 375                 380                 


Ala Ala Gly Cys Gly Gly Ala Cys Ala Gly Thr Gly Gly Cys Cys Gly 
385                 390                 395                 400 


Cys Thr Cys Cys Thr Ala Gly Cys Gly Thr Gly Thr Thr Cys Ala Thr 
                405                 410                 415     


Cys Thr Thr Thr Cys Cys Ala Cys Cys Thr Ala Gly Cys Gly Ala Cys 
            420                 425                 430         


Gly Ala Gly Cys Ala Gly Cys Thr Gly Ala Ala Gly Thr Cys Thr Gly 
        435                 440                 445             


Gly Cys Ala Cys Ala Gly Cys Cys Thr Cys Thr Gly Thr Cys Gly Thr 
    450                 455                 460                 


Gly Thr Gly Cys Cys Thr Gly Cys Thr Gly Ala Ala Cys Ala Ala Cys 
465                 470                 475                 480 


Thr Thr Cys Thr Ala Cys Cys Cys Cys Ala Gly Ala Gly Ala Ala Gly 
                485                 490                 495     


Cys Cys Ala Ala Gly Gly Thr Gly Cys Ala Gly Thr Gly Gly Ala Ala 
            500                 505                 510         


Gly Gly Thr Gly Gly Ala Cys Ala Ala Cys Gly Cys Cys Cys Thr Gly 
        515                 520                 525             


Cys Ala Gly Ala Gly Cys Gly Gly Cys Ala Ala Thr Ala Gly Cys Cys 
    530                 535                 540                 


Ala Ala Gly Ala Gly Ala Gly Cys Gly Thr Gly Ala Cys Cys Gly Ala 
545                 550                 555                 560 


Gly Cys Ala Gly Gly Ala Cys Ala Gly Cys Ala Ala Gly Gly Ala Cys 
                565                 570                 575     


Thr Cys Thr Ala Cys Cys Thr Ala Cys Ala Gly Cys Cys Thr Gly Thr 
            580                 585                 590         


Cys Cys Ala Gly Cys Ala Cys Ala Cys Thr Gly Ala Cys Cys Cys Thr 
        595                 600                 605             


Gly Ala Gly Cys Ala Ala Gly Gly Cys Cys Gly Ala Cys Thr Ala Cys 
    610                 615                 620                 


Gly Ala Gly Ala Ala Gly Cys Ala Cys Ala Ala Ala Gly Thr Gly Thr 
625                 630                 635                 640 


Ala Cys Gly Cys Cys Thr Gly Cys Gly Ala Ala Gly Thr Gly Ala Cys 
                645                 650                 655     


Cys Cys Ala Cys Cys Ala Gly Gly Gly Cys Cys Thr Thr Thr Cys Thr 
            660                 665                 670         


Ala Gly Cys Cys Cys Thr Gly Thr Gly Ala Cys Cys Ala Ala Gly Ala 
        675                 680                 685             


Gly Cys Thr Thr Cys Ala Ala Cys Cys Gly Gly Gly Gly Cys Gly Ala 
    690                 695                 700                 


Gly Thr Gly Cys Thr Gly Ala Thr Gly Ala 
705                 710                 


<210>  45
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 antibody

<400>  45

Ala Thr Gly Gly Ala Cys Ala Thr Gly Ala Gly Ala Gly Thr Gly Cys 
1               5                   10                  15      


Thr Gly Gly Cys Cys Cys Ala Ala Cys Thr Gly Cys Thr Gly Gly Gly 
            20                  25                  30          


Ala Cys Thr Gly Cys Thr Gly Cys Thr Gly Cys Thr Thr Thr Gly Thr 
        35                  40                  45              


Thr Thr Cys Cys Cys Thr Gly Gly Cys Gly Cys Thr Ala Gly Ala Thr 
    50                  55                  60                  


Gly Cys Gly Ala Cys Ala Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys 
65                  70                  75                  80  


Ala Cys Ala Gly Ala Gly Cys Cys Cys Cys Ala Gly Cys Ala Gly Cys 
                85                  90                  95      


Cys Thr Gly Thr Cys Thr Gly Cys Cys Thr Cys Thr Gly Thr Gly Gly 
            100                 105                 110         


Gly Ala Gly Ala Cys Ala Gly Ala Gly Thr Gly Ala Cys Cys Ala Thr 
        115                 120                 125             


Cys Ala Cys Cys Thr Gly Thr Ala Gly Ala Gly Cys Cys Ala Gly Cys 
    130                 135                 140                 


Cys Ala Gly Gly Ala Cys Ala Thr Cys Ala Gly Cys Ala Ala Cys Thr 
145                 150                 155                 160 


Ala Cys Cys Thr Gly Ala Ala Cys Thr Gly Gly Thr Ala Thr Cys Ala 
                165                 170                 175     


Gly Cys Ala Gly Ala Ala Ala Cys Cys Cys Gly Ala Cys Gly Gly Cys 
            180                 185                 190         


Ala Cys Cys Gly Thr Gly Ala Ala Gly Cys Thr Gly Cys Thr Gly Ala 
        195                 200                 205             


Thr Cys Thr Ala Cys Thr Ala Cys Ala Cys Cys Ala Gly Cys Ala Gly 
    210                 215                 220                 


Ala Cys Thr Gly Cys Ala Cys Ala Gly Cys Gly Gly Cys Gly Thr Gly 
225                 230                 235                 240 


Cys Cys Cys Ala Gly Cys Ala Gly Ala Thr Thr Thr Thr Cys Thr Gly 
                245                 250                 255     


Gly Cys Thr Cys Thr Gly Gly Cys Ala Gly Cys Gly Gly Cys Ala Cys 
            260                 265                 270         


Cys Gly Ala Cys Thr Ala Cys Ala Cys Cys Cys Thr Gly Ala Cys Cys 
        275                 280                 285             


Ala Thr Ala Thr Cys Thr Ala Gly Cys Cys Thr Gly Cys Ala Gly Cys 
    290                 295                 300                 


Cys Thr Gly Ala Gly Gly Ala Thr Ala Thr Cys Gly Cys Cys Ala Cys 
305                 310                 315                 320 


Cys Thr Ala Cys Thr Ala Cys Thr Gly Cys Cys Ala Gly Cys Ala Gly 
                325                 330                 335     


Gly Gly Cys Ala Ala Gly Ala Cys Cys Cys Thr Gly Cys Cys Thr Cys 
            340                 345                 350         


Cys Thr Ala Cys Ala Thr Thr Thr Gly Gly Cys Gly Gly Cys Gly Gly 
        355                 360                 365             


Ala Ala Cys Ala Ala Ala Gly Cys Thr Gly Gly Ala Ala Ala Thr Cys 
    370                 375                 380                 


Ala Ala Gly Cys Gly Gly Ala Cys Ala Gly Thr Gly Gly Cys Cys Gly 
385                 390                 395                 400 


Cys Thr Cys Cys Thr Ala Gly Cys Gly Thr Gly Thr Thr Cys Ala Thr 
                405                 410                 415     


Cys Thr Thr Thr Cys Cys Ala Cys Cys Thr Ala Gly Cys Gly Ala Cys 
            420                 425                 430         


Gly Ala Gly Cys Ala Gly Cys Thr Gly Ala Ala Gly Thr Cys Thr Gly 
        435                 440                 445             


Gly Cys Ala Cys Ala Gly Cys Cys Thr Cys Thr Gly Thr Cys Gly Thr 
    450                 455                 460                 


Gly Thr Gly Cys Cys Thr Gly Cys Thr Gly Ala Ala Cys Ala Ala Cys 
465                 470                 475                 480 


Thr Thr Cys Thr Ala Cys Cys Cys Cys Ala Gly Ala Gly Ala Ala Gly 
                485                 490                 495     


Cys Cys Ala Ala Gly Gly Thr Gly Cys Ala Gly Thr Gly Gly Ala Ala 
            500                 505                 510         


Gly Gly Thr Gly Gly Ala Cys Ala Ala Cys Gly Cys Cys Cys Thr Gly 
        515                 520                 525             


Cys Ala Gly Ala Gly Cys Gly Gly Cys Ala Ala Thr Ala Gly Cys Cys 
    530                 535                 540                 


Ala Ala Gly Ala Gly Ala Gly Cys Gly Thr Gly Ala Cys Cys Gly Ala 
545                 550                 555                 560 


Gly Cys Ala Gly Gly Ala Cys Ala Gly Cys Ala Ala Gly Gly Ala Cys 
                565                 570                 575     


Thr Cys Thr Ala Cys Cys Thr Ala Cys Ala Gly Cys Cys Thr Gly Thr 
            580                 585                 590         


Cys Cys Ala Gly Cys Ala Cys Ala Cys Thr Gly Ala Cys Cys Cys Thr 
        595                 600                 605             


Gly Ala Gly Cys Ala Ala Gly Gly Cys Cys Gly Ala Cys Thr Ala Cys 
    610                 615                 620                 


Gly Ala Gly Ala Ala Gly Cys Ala Cys Ala Ala Ala Gly Thr Gly Thr 
625                 630                 635                 640 


Ala Cys Gly Cys Cys Thr Gly Cys Gly Ala Ala Gly Thr Gly Ala Cys 
                645                 650                 655     


Cys Cys Ala Cys Cys Ala Gly Gly Gly Cys Cys Thr Thr Thr Cys Thr 
            660                 665                 670         


Ala Gly Cys Cys Cys Thr Gly Thr Gly Ala Cys Cys Ala Ala Gly Ala 
        675                 680                 685             


Gly Cys Thr Thr Cys Ala Ala Cys Cys Gly Gly Gly Gly Cys Gly Ala 
    690                 695                 700                 


Gly Thr Gly Cys Thr Gly Ala Thr Gly Ala 
705                 710                 


<210>  46
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 antibody

<400>  46

Ala Thr Gly Gly Ala Cys Ala Thr Gly Ala Gly Ala Gly Thr Gly Cys 
1               5                   10                  15      


Thr Gly Gly Cys Cys Cys Ala Ala Cys Thr Gly Cys Thr Gly Gly Gly 
            20                  25                  30          


Ala Cys Thr Gly Cys Thr Gly Cys Thr Gly Cys Thr Thr Thr Gly Thr 
        35                  40                  45              


Thr Thr Cys Cys Cys Thr Gly Gly Cys Gly Cys Thr Ala Gly Ala Thr 
    50                  55                  60                  


Gly Cys Gly Ala Cys Ala Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys 
65                  70                  75                  80  


Ala Cys Ala Gly Ala Gly Cys Cys Cys Cys Ala Gly Cys Ala Gly Cys 
                85                  90                  95      


Cys Thr Gly Thr Cys Thr Gly Cys Cys Thr Cys Thr Gly Thr Gly Gly 
            100                 105                 110         


Gly Ala Gly Ala Cys Ala Gly Ala Gly Thr Gly Ala Cys Cys Ala Thr 
        115                 120                 125             


Cys Ala Cys Cys Thr Gly Thr Ala Gly Ala Gly Cys Cys Ala Gly Cys 
    130                 135                 140                 


Cys Ala Gly Gly Ala Cys Ala Thr Cys Ala Gly Cys Ala Ala Cys Thr 
145                 150                 155                 160 


Ala Cys Cys Thr Gly Ala Ala Cys Thr Gly Gly Thr Ala Thr Cys Ala 
                165                 170                 175     


Gly Cys Ala Gly Ala Ala Ala Cys Cys Cys Gly Ala Cys Gly Gly Cys 
            180                 185                 190         


Ala Cys Cys Gly Thr Gly Ala Ala Gly Cys Thr Gly Cys Thr Gly Ala 
        195                 200                 205             


Thr Cys Thr Ala Cys Thr Ala Cys Ala Cys Cys Ala Gly Cys Ala Gly 
    210                 215                 220                 


Ala Cys Thr Gly Cys Ala Cys Ala Gly Cys Gly Gly Cys Gly Thr Gly 
225                 230                 235                 240 


Cys Cys Cys Ala Gly Cys Ala Gly Ala Thr Thr Thr Thr Cys Thr Gly 
                245                 250                 255     


Gly Cys Thr Cys Thr Gly Gly Cys Ala Gly Cys Gly Gly Cys Ala Cys 
            260                 265                 270         


Cys Gly Ala Cys Thr Ala Cys Ala Cys Cys Cys Thr Gly Ala Cys Cys 
        275                 280                 285             


Ala Thr Ala Thr Cys Thr Ala Gly Cys Cys Thr Gly Cys Ala Gly Cys 
    290                 295                 300                 


Cys Thr Gly Ala Gly Gly Ala Thr Ala Thr Cys Gly Cys Thr Ala Cys 
305                 310                 315                 320 


Cys Thr Ala Cys Thr Thr Cys Thr Gly Cys Cys Ala Gly Cys Ala Ala 
                325                 330                 335     


Gly Gly Cys Ala Ala Gly Ala Cys Cys Cys Thr Gly Cys Cys Thr Cys 
            340                 345                 350         


Cys Thr Ala Cys Ala Thr Thr Thr Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Cys Ala Cys Cys Ala Ala Gly Cys Thr Gly Gly Ala Ala Ala Thr Cys 
    370                 375                 380                 


Ala Ala Gly Cys Gly Gly Ala Cys Ala Gly Thr Gly Gly Cys Cys Gly 
385                 390                 395                 400 


Cys Thr Cys Cys Thr Ala Gly Cys Gly Thr Gly Thr Thr Cys Ala Thr 
                405                 410                 415     


Cys Thr Thr Thr Cys Cys Ala Cys Cys Thr Ala Gly Cys Gly Ala Cys 
            420                 425                 430         


Gly Ala Gly Cys Ala Gly Cys Thr Gly Ala Ala Gly Thr Cys Thr Gly 
        435                 440                 445             


Gly Cys Ala Cys Ala Gly Cys Cys Thr Cys Thr Gly Thr Cys Gly Thr 
    450                 455                 460                 


Gly Thr Gly Cys Cys Thr Gly Cys Thr Gly Ala Ala Cys Ala Ala Cys 
465                 470                 475                 480 


Thr Thr Cys Thr Ala Cys Cys Cys Cys Ala Gly Ala Gly Ala Ala Gly 
                485                 490                 495     


Cys Cys Ala Ala Gly Gly Thr Gly Cys Ala Gly Thr Gly Gly Ala Ala 
            500                 505                 510         


Gly Gly Thr Gly Gly Ala Cys Ala Ala Cys Gly Cys Cys Cys Thr Gly 
        515                 520                 525             


Cys Ala Gly Ala Gly Cys Gly Gly Cys Ala Ala Thr Ala Gly Cys Cys 
    530                 535                 540                 


Ala Ala Gly Ala Gly Ala Gly Cys Gly Thr Gly Ala Cys Cys Gly Ala 
545                 550                 555                 560 


Gly Cys Ala Gly Gly Ala Cys Ala Gly Cys Ala Ala Gly Gly Ala Cys 
                565                 570                 575     


Thr Cys Thr Ala Cys Cys Thr Ala Thr Ala Gly Cys Cys Thr Gly Ala 
            580                 585                 590         


Gly Cys Ala Gly Cys Ala Cys Cys Cys Thr Gly Ala Cys Ala Cys Thr 
        595                 600                 605             


Gly Ala Gly Cys Ala Ala Gly Gly Cys Cys Gly Ala Cys Thr Ala Cys 
    610                 615                 620                 


Gly Ala Gly Ala Ala Gly Cys Ala Cys Ala Ala Ala Gly Thr Gly Thr 
625                 630                 635                 640 


Ala Cys Gly Cys Cys Thr Gly Cys Gly Ala Ala Gly Thr Gly Ala Cys 
                645                 650                 655     


Cys Cys Ala Cys Cys Ala Gly Gly Gly Cys Cys Thr Thr Thr Cys Thr 
            660                 665                 670         


Ala Gly Cys Cys Cys Thr Gly Thr Gly Ala Cys Cys Ala Ala Gly Ala 
        675                 680                 685             


Gly Cys Thr Thr Cys Ala Ala Cys Cys Gly Gly Gly Gly Cys Gly Ala 
    690                 695                 700                 


Gly Thr Gly Cys Thr Gly Ala Thr Gly Ala 
705                 710                 


<210>  47
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 antibody

<400>  47

Ala Thr Gly Gly Ala Cys Ala Thr Gly Ala Gly Ala Gly Thr Gly Cys 
1               5                   10                  15      


Thr Gly Gly Cys Cys Cys Ala Ala Cys Thr Gly Cys Thr Gly Gly Gly 
            20                  25                  30          


Ala Cys Thr Gly Cys Thr Gly Cys Thr Gly Cys Thr Thr Thr Gly Thr 
        35                  40                  45              


Thr Thr Cys Cys Cys Thr Gly Gly Cys Gly Cys Thr Ala Gly Ala Thr 
    50                  55                  60                  


Gly Cys Gly Ala Cys Ala Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys 
65                  70                  75                  80  


Ala Cys Ala Gly Ala Gly Cys Cys Cys Cys Ala Gly Cys Ala Gly Cys 
                85                  90                  95      


Cys Thr Gly Thr Cys Thr Gly Cys Cys Thr Cys Thr Gly Thr Gly Gly 
            100                 105                 110         


Gly Ala Gly Ala Cys Ala Gly Ala Gly Thr Gly Ala Cys Cys Ala Thr 
        115                 120                 125             


Cys Ala Cys Cys Thr Gly Thr Ala Gly Ala Gly Cys Cys Ala Gly Cys 
    130                 135                 140                 


Cys Ala Gly Gly Ala Cys Ala Thr Cys Ala Gly Cys Ala Ala Cys Thr 
145                 150                 155                 160 


Ala Cys Cys Thr Gly Ala Ala Cys Thr Gly Gly Thr Ala Thr Cys Ala 
                165                 170                 175     


Gly Cys Ala Gly Ala Ala Ala Cys Cys Cys Gly Ala Cys Gly Gly Cys 
            180                 185                 190         


Ala Cys Cys Gly Thr Gly Ala Ala Gly Cys Thr Gly Cys Thr Gly Ala 
        195                 200                 205             


Thr Cys Thr Ala Cys Thr Ala Cys Ala Cys Cys Ala Gly Cys Ala Gly 
    210                 215                 220                 


Ala Cys Thr Gly Cys Ala Cys Ala Gly Cys Gly Gly Cys Gly Thr Gly 
225                 230                 235                 240 


Cys Cys Cys Ala Gly Cys Ala Gly Ala Thr Thr Thr Thr Cys Thr Gly 
                245                 250                 255     


Gly Cys Thr Cys Thr Gly Gly Cys Ala Gly Cys Gly Gly Cys Ala Cys 
            260                 265                 270         


Cys Gly Ala Cys Thr Ala Cys Ala Cys Cys Cys Thr Gly Ala Cys Cys 
        275                 280                 285             


Ala Thr Ala Thr Cys Thr Ala Gly Cys Cys Thr Gly Gly Ala Ala Cys 
    290                 295                 300                 


Cys Thr Gly Ala Gly Gly Ala Thr Ala Thr Cys Gly Cys Thr Ala Cys 
305                 310                 315                 320 


Cys Thr Ala Cys Thr Thr Cys Thr Gly Cys Cys Ala Gly Cys Ala Ala 
                325                 330                 335     


Gly Gly Cys Ala Ala Gly Ala Cys Cys Cys Thr Gly Cys Cys Thr Cys 
            340                 345                 350         


Cys Thr Ala Cys Ala Thr Thr Thr Gly Gly Cys Gly Gly Ala Gly Gly 
        355                 360                 365             


Cys Ala Cys Cys Ala Ala Gly Cys Thr Gly Gly Ala Ala Ala Thr Cys 
    370                 375                 380                 


Ala Ala Gly Cys Gly Gly Ala Cys Ala Gly Thr Gly Gly Cys Cys Gly 
385                 390                 395                 400 


Cys Thr Cys Cys Thr Ala Gly Cys Gly Thr Gly Thr Thr Cys Ala Thr 
                405                 410                 415     


Cys Thr Thr Thr Cys Cys Ala Cys Cys Thr Ala Gly Cys Gly Ala Cys 
            420                 425                 430         


Gly Ala Gly Cys Ala Gly Cys Thr Gly Ala Ala Gly Thr Cys Thr Gly 
        435                 440                 445             


Gly Cys Ala Cys Ala Gly Cys Cys Thr Cys Thr Gly Thr Cys Gly Thr 
    450                 455                 460                 


Gly Thr Gly Cys Cys Thr Gly Cys Thr Gly Ala Ala Cys Ala Ala Cys 
465                 470                 475                 480 


Thr Thr Cys Thr Ala Cys Cys Cys Cys Ala Gly Ala Gly Ala Ala Gly 
                485                 490                 495     


Cys Cys Ala Ala Gly Gly Thr Gly Cys Ala Gly Thr Gly Gly Ala Ala 
            500                 505                 510         


Gly Gly Thr Gly Gly Ala Cys Ala Ala Cys Gly Cys Cys Cys Thr Gly 
        515                 520                 525             


Cys Ala Gly Ala Gly Cys Gly Gly Cys Ala Ala Thr Ala Gly Cys Cys 
    530                 535                 540                 


Ala Ala Gly Ala Gly Ala Gly Cys Gly Thr Gly Ala Cys Cys Gly Ala 
545                 550                 555                 560 


Gly Cys Ala Gly Gly Ala Cys Ala Gly Cys Ala Ala Gly Gly Ala Cys 
                565                 570                 575     


Thr Cys Thr Ala Cys Cys Thr Ala Cys Ala Gly Cys Cys Thr Gly Ala 
            580                 585                 590         


Gly Cys Ala Gly Cys Ala Cys Cys Cys Thr Gly Ala Cys Ala Cys Thr 
        595                 600                 605             


Gly Ala Gly Cys Ala Ala Gly Gly Cys Cys Gly Ala Cys Thr Ala Cys 
    610                 615                 620                 


Gly Ala Gly Ala Ala Gly Cys Ala Cys Ala Ala Ala Gly Thr Gly Thr 
625                 630                 635                 640 


Ala Cys Gly Cys Cys Thr Gly Cys Gly Ala Ala Gly Thr Gly Ala Cys 
                645                 650                 655     


Cys Cys Ala Cys Cys Ala Gly Gly Gly Cys Cys Thr Thr Thr Cys Thr 
            660                 665                 670         


Ala Gly Cys Cys Cys Thr Gly Thr Gly Ala Cys Cys Ala Ala Gly Ala 
        675                 680                 685             


Gly Cys Thr Thr Cys Ala Ala Cys Cys Gly Gly Gly Gly Cys Gly Ala 
    690                 695                 700                 


Gly Thr Gly Cys Thr Gly Ala Thr Gly Ala 
705                 710                 


<210>  48
<211>  1416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 antibody

<400>  48

Ala Thr Gly Gly Ala Ala Thr Thr Thr Thr Gly Gly Cys Thr Gly Ala 
1               5                   10                  15      


Gly Cys Thr Gly Gly Gly Thr Gly Thr Thr Cys Cys Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Cys Ala Thr Cys Cys Thr Gly Ala Ala Ala Gly Gly Cys 
        35                  40                  45              


Gly Thr Gly Cys Ala Gly Thr Gly Cys Gly Ala Ala Gly Thr Gly Cys 
    50                  55                  60                  


Ala Gly Cys Thr Gly Gly Thr Thr Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Cys Gly Cys Cys Gly Ala Ala Gly Thr Gly Ala Ala Ala Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Cys Gly Cys Cys Ala Cys Cys Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Ala Thr Cys Ala Gly Cys Thr Gly Thr Ala Cys Cys Gly Cys 
        115                 120                 125             


Cys Ala Gly Cys Gly Gly Cys Thr Thr Cys Ala Ala Cys Ala Thr Cys 
    130                 135                 140                 


Ala Ala Gly Gly Ala Cys Gly Ala Cys Thr Ala Cys Cys Thr Gly Cys 
145                 150                 155                 160 


Ala Cys Thr Gly Gly Gly Thr Cys Cys Gly Ala Cys Ala Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Thr Gly Gly Ala Ala Ala Ala Gly Gly Ala Cys Thr Gly 
            180                 185                 190         


Gly Ala Ala Thr Gly Gly Ala Thr Cys Gly Gly Cys Ala Gly Ala Ala 
        195                 200                 205             


Thr Cys Gly Ala Cys Cys Cys Cys Gly Cys Cys Ala Ala Cys Gly Gly 
    210                 215                 220                 


Cys Ala Ala Cys Ala Cys Cys Ala Ala Ala Thr Ala Cys Gly Cys Cys 
225                 230                 235                 240 


Cys Cys Thr Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Ala Cys Ala 
                245                 250                 255     


Gly Ala Gly Thr Gly Ala Cys Cys Ala Thr Cys Ala Cys Cys Gly Cys 
            260                 265                 270         


Cys Gly Ala Cys Ala Cys Cys Ala Gly Cys Ala Cys Cys Ala Ala Thr 
        275                 280                 285             


Ala Cys Cys Gly Cys Cys Thr Ala Cys Cys Thr Gly Gly Ala Ala Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Ala Ala Gly 
305                 310                 315                 320 


Cys Gly Ala Gly Gly Ala Cys Ala Cys Cys Gly Cys Cys Gly Thr Gly 
                325                 330                 335     


Thr Ala Cys Thr Ala Thr Thr Gly Cys Gly Cys Cys Gly Cys Cys Ala 
            340                 345                 350         


Gly Ala Thr Thr Cys Gly Gly Cys Thr Ala Cys Thr Thr Cys Thr Ala 
        355                 360                 365             


Cys Gly Gly Cys Ala Gly Cys Ala Gly Cys Thr Thr Thr Thr Ala Cys 
    370                 375                 380                 


Gly Cys Cys Gly Thr Gly Gly Cys Cys Thr Ala Thr Thr Gly Gly Gly 
385                 390                 395                 400 


Gly Ala Cys Ala Gly Gly Gly Cys Ala Cys Cys Cys Thr Gly Gly Thr 
                405                 410                 415     


Thr Ala Cys Ala Gly Thr Gly Thr Cys Cys Ala Gly Cys Gly Cys Cys 
            420                 425                 430         


Thr Cys Thr Ala Cys Ala Ala Ala Gly Gly Gly Cys Cys Cys Cys Thr 
        435                 440                 445             


Cys Cys Gly Thr Thr Thr Thr Thr Cys Cys Ala Cys Thr Gly Gly Cys 
    450                 455                 460                 


Thr Cys Cys Cys Thr Gly Thr Ala Gly Cys Ala Gly Ala Ala Gly Cys 
465                 470                 475                 480 


Ala Cys Cys Ala Gly Cys Gly Ala Ala Thr Cys Thr Ala Cys Ala Gly 
                485                 490                 495     


Cys Cys Gly Cys Thr Cys Thr Gly Gly Gly Cys Thr Gly Cys Cys Thr 
            500                 505                 510         


Gly Gly Thr Cys Ala Ala Gly Gly Ala Cys Thr Ala Cys Thr Thr Thr 
        515                 520                 525             


Cys Cys Thr Gly Ala Gly Cys Cys Thr Gly Thr Gly Ala Cys Cys Gly 
    530                 535                 540                 


Thr Gly Thr Cys Thr Thr Gly Gly Ala Ala Cys Thr Cys Thr Gly Gly 
545                 550                 555                 560 


Cys Gly Cys Thr Cys Thr Gly Ala Cys Ala Ala Gly Cys Gly Gly Cys 
                565                 570                 575     


Gly Thr Gly Cys Ala Cys Ala Cys Ala Thr Thr Thr Cys Cys Ala Gly 
            580                 585                 590         


Cys Cys Gly Thr Gly Cys Thr Gly Cys Ala Ala Ala Gly Cys Ala Gly 
        595                 600                 605             


Cys Gly Gly Cys Cys Thr Gly Thr Ala Cys Thr Cys Thr Cys Thr Gly 
    610                 615                 620                 


Ala Gly Cys Ala Gly Cys Gly Thr Gly Gly Thr Cys Ala Cys Ala Gly 
625                 630                 635                 640 


Thr Gly Cys Cys Thr Ala Gly Cys Thr Cys Thr Ala Gly Cys Cys Thr 
                645                 650                 655     


Gly Gly Gly Cys Ala Cys Cys Ala Ala Gly Ala Cys Cys Thr Ala Cys 
            660                 665                 670         


Ala Cys Cys Thr Gly Thr Ala Ala Thr Gly Thr Gly Gly Ala Cys Cys 
        675                 680                 685             


Ala Cys Ala Ala Gly Cys Cys Thr Thr Cys Cys Ala Ala Cys Ala Cys 
    690                 695                 700                 


Cys Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala Gly Cys Gly Cys 
705                 710                 715                 720 


Gly Thr Gly Gly Ala Ala Thr Cys Thr Ala Ala Gly Thr Ala Cys Gly 
                725                 730                 735     


Gly Cys Cys Cys Thr Cys Cys Thr Thr Gly Thr Cys Cys Thr Cys Cys 
            740                 745                 750         


Ala Thr Gly Thr Cys Cys Thr Gly Cys Ala Cys Cys Thr Gly Ala Gly 
        755                 760                 765             


Thr Thr Thr Cys Thr Cys Gly Gly Cys Gly Gly Ala Cys Cys Cys Thr 
    770                 775                 780                 


Cys Cys Gly Thr Gly Thr Thr Cys Cys Thr Gly Thr Thr Thr Cys Cys 
785                 790                 795                 800 


Thr Cys Cys Ala Ala Ala Gly Cys Cys Thr Ala Ala Gly Gly Ala Cys 
                805                 810                 815     


Ala Cys Cys Cys Thr Gly Ala Thr Gly Ala Thr Cys Ala Gly Cys Ala 
            820                 825                 830         


Gly Ala Ala Cys Cys Cys Cys Thr Gly Ala Ala Gly Thr Gly Ala Cys 
        835                 840                 845             


Cys Thr Gly Cys Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly Ala Cys 
    850                 855                 860                 


Gly Thr Gly Thr Cys Cys Cys Ala Ala Gly Ala Gly Gly Ala Thr Cys 
865                 870                 875                 880 


Cys Thr Gly Ala Gly Gly Thr Gly Cys Ala Gly Thr Thr Cys Ala Ala 
                885                 890                 895     


Thr Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys 
            900                 905                 910         


Gly Thr Gly Gly Ala Ala Gly Thr Gly Cys Ala Cys Ala Ala Cys Gly 
        915                 920                 925             


Cys Cys Ala Ala Gly Ala Cys Cys Ala Ala Gly Cys Cys Thr Ala Gly 
    930                 935                 940                 


Ala Gly Ala Gly Gly Ala Ala Cys Ala Gly Thr Thr Cys Ala Ala Cys 
945                 950                 955                 960 


Ala Gly Cys Ala Cys Cys Thr Ala Cys Ala Gly Ala Gly Thr Gly Gly 
                965                 970                 975     


Thr Gly Thr Cys Cys Gly Thr Gly Cys Thr Gly Ala Cys Ala Gly Thr 
            980                 985                 990         


Gly Cys Thr Gly Cys Ala Cys Cys  Ala Gly Gly Ala Thr  Thr Gly Gly 
        995                 1000                 1005             


Cys Thr  Gly Ala Ala Cys Gly  Gly Cys Ala Ala Ala  Gly Ala Gly 
    1010                 1015                 1020             


Thr Ala  Cys Ala Ala Gly Thr  Gly Cys Ala Ala Gly  Gly Thr Gly 
    1025                 1030                 1035             


Thr Cys  Cys Ala Ala Cys Ala  Ala Gly Gly Gly Cys  Cys Thr Gly 
    1040                 1045                 1050             


Cys Cys  Thr Ala Gly Cys Ala  Gly Cys Ala Thr Cys  Gly Ala Gly 
    1055                 1060                 1065             


Ala Ala  Ala Ala Cys Cys Ala  Thr Cys Ala Gly Cys  Ala Ala Gly 
    1070                 1075                 1080             


Gly Cys  Cys Ala Ala Gly Gly  Gly Cys Cys Ala Gly  Cys Cys Ala 
    1085                 1090                 1095             


Ala Gly  Ala Gly Ala Ala Cys  Cys Cys Cys Ala Gly  Gly Thr Gly 
    1100                 1105                 1110             


Thr Ala  Cys Ala Cys Ala Cys  Thr Gly Cys Cys Thr  Cys Cys Ala 
    1115                 1120                 1125             


Ala Gly  Cys Cys Ala Ala Gly  Ala Gly Gly Ala Ala  Ala Thr Gly 
    1130                 1135                 1140             


Ala Cys  Cys Ala Ala Gly Ala  Ala Cys Cys Ala Gly  Gly Thr Gly 
    1145                 1150                 1155             


Thr Cys  Cys Cys Thr Gly Ala  Cys Cys Thr Gly Cys  Cys Thr Cys 
    1160                 1165                 1170             


Gly Thr  Gly Ala Ala Gly Gly  Gly Cys Thr Thr Cys  Thr Ala Cys 
    1175                 1180                 1185             


Cys Cys  Thr Thr Cys Cys Gly  Ala Thr Ala Thr Cys  Gly Cys Cys 
    1190                 1195                 1200             


Gly Thr  Gly Gly Ala Ala Thr  Gly Gly Gly Ala Gly  Ala Gly Cys 
    1205                 1210                 1215             


Ala Ala  Thr Gly Gly Ala Cys  Ala Gly Cys Cys Cys  Gly Ala Gly 
    1220                 1225                 1230             


Ala Ala  Cys Ala Ala Cys Thr  Ala Cys Ala Ala Gly  Ala Cys Ala 
    1235                 1240                 1245             


Ala Cys  Cys Cys Cys Thr Cys  Cys Thr Gly Thr Gly  Cys Thr Gly 
    1250                 1255                 1260             


Gly Ala  Cys Ala Gly Cys Gly  Ala Cys Gly Gly Cys  Thr Cys Ala 
    1265                 1270                 1275             


Thr Thr  Cys Thr Thr Cys Cys  Thr Gly Thr Ala Cys  Ala Gly Cys 
    1280                 1285                 1290             


Ala Gly  Ala Cys Thr Gly Ala  Cys Cys Gly Thr Gly  Gly Ala Cys 
    1295                 1300                 1305             


Ala Ala  Gly Ala Gly Cys Ala  Gly Ala Thr Gly Gly  Cys Ala Ala 
    1310                 1315                 1320             


Gly Ala  Gly Gly Gly Cys Ala  Ala Cys Gly Thr Gly  Thr Thr Cys 
    1325                 1330                 1335             


Ala Gly  Cys Thr Gly Cys Ala  Gly Cys Gly Thr Gly  Ala Thr Gly 
    1340                 1345                 1350             


Cys Ala  Cys Gly Ala Gly Gly  Cys Cys Cys Thr Gly  Cys Ala Cys 
    1355                 1360                 1365             


Ala Ala  Cys Cys Ala Cys Thr  Ala Cys Ala Cys Cys  Cys Ala Gly 
    1370                 1375                 1380             


Ala Ala  Gly Thr Cys Thr Cys  Thr Gly Thr Cys Cys  Cys Thr Gly 
    1385                 1390                 1395             


Thr Cys  Thr Cys Thr Gly Gly  Gly Cys Ala Ala Gly  Thr Gly Ala 
    1400                 1405                 1410             


Thr Gly  Ala 
    1415     


<210>  49
<211>  1416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 antibody

<400>  49

Ala Thr Gly Gly Ala Ala Thr Thr Thr Thr Gly Gly Cys Thr Gly Ala 
1               5                   10                  15      


Gly Cys Thr Gly Gly Gly Thr Gly Thr Thr Cys Cys Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Cys Ala Thr Cys Cys Thr Gly Ala Ala Ala Gly Gly Cys 
        35                  40                  45              


Gly Thr Gly Cys Ala Gly Thr Gly Cys Gly Ala Ala Gly Thr Thr Cys 
    50                  55                  60                  


Ala Gly Cys Thr Gly Cys Ala Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Cys Gly Cys Cys Gly Ala Ala Gly Thr Gly Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Cys Cys Thr Gly Gly Cys Gly Cys Cys Ala Cys Cys Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Ala Thr Cys Ala Gly Cys Thr Gly Thr Ala Cys Cys Gly Cys 
        115                 120                 125             


Cys Ala Gly Cys Gly Gly Cys Thr Thr Cys Ala Ala Cys Ala Thr Cys 
    130                 135                 140                 


Ala Ala Gly Gly Ala Cys Gly Ala Cys Thr Ala Cys Cys Thr Gly Cys 
145                 150                 155                 160 


Ala Cys Thr Gly Gly Gly Thr Cys Cys Gly Ala Cys Ala Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Thr Gly Gly Ala Ala Ala Ala Gly Gly Ala Cys Thr Gly 
            180                 185                 190         


Gly Ala Ala Thr Gly Gly Ala Thr Cys Gly Gly Cys Ala Gly Ala Ala 
        195                 200                 205             


Thr Cys Gly Ala Cys Cys Cys Cys Gly Cys Cys Ala Ala Cys Gly Gly 
    210                 215                 220                 


Cys Ala Ala Cys Ala Cys Cys Ala Ala Ala Thr Ala Cys Gly Cys Cys 
225                 230                 235                 240 


Cys Cys Thr Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Ala Cys Ala 
                245                 250                 255     


Gly Ala Gly Thr Gly Ala Cys Cys Ala Thr Cys Ala Cys Cys Gly Cys 
            260                 265                 270         


Cys Gly Ala Cys Ala Cys Cys Ala Gly Cys Ala Cys Cys Ala Ala Thr 
        275                 280                 285             


Ala Cys Cys Gly Cys Cys Thr Ala Cys Cys Thr Gly Gly Ala Ala Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Ala Ala Gly 
305                 310                 315                 320 


Cys Gly Ala Gly Gly Ala Cys Ala Cys Cys Gly Cys Cys Gly Thr Gly 
                325                 330                 335     


Thr Ala Cys Thr Ala Thr Thr Gly Cys Gly Cys Cys Gly Cys Cys Ala 
            340                 345                 350         


Gly Ala Thr Thr Cys Gly Gly Cys Thr Ala Cys Thr Thr Cys Thr Ala 
        355                 360                 365             


Cys Gly Gly Cys Ala Gly Cys Ala Gly Cys Thr Thr Thr Thr Ala Cys 
    370                 375                 380                 


Gly Cys Cys Gly Thr Gly Gly Cys Cys Thr Ala Thr Thr Gly Gly Gly 
385                 390                 395                 400 


Gly Ala Cys Ala Gly Gly Gly Cys Ala Cys Cys Cys Thr Gly Gly Thr 
                405                 410                 415     


Thr Ala Cys Ala Gly Thr Gly Thr Cys Cys Ala Gly Cys Gly Cys Cys 
            420                 425                 430         


Thr Cys Thr Ala Cys Ala Ala Ala Gly Gly Gly Cys Cys Cys Cys Thr 
        435                 440                 445             


Cys Cys Gly Thr Thr Thr Thr Thr Cys Cys Ala Cys Thr Gly Gly Cys 
    450                 455                 460                 


Thr Cys Cys Cys Thr Gly Thr Ala Gly Cys Ala Gly Ala Ala Gly Cys 
465                 470                 475                 480 


Ala Cys Cys Ala Gly Cys Gly Ala Ala Thr Cys Thr Ala Cys Ala Gly 
                485                 490                 495     


Cys Cys Gly Cys Thr Cys Thr Gly Gly Gly Cys Thr Gly Cys Cys Thr 
            500                 505                 510         


Gly Gly Thr Cys Ala Ala Gly Gly Ala Cys Thr Ala Cys Thr Thr Thr 
        515                 520                 525             


Cys Cys Thr Gly Ala Gly Cys Cys Thr Gly Thr Gly Ala Cys Cys Gly 
    530                 535                 540                 


Thr Gly Thr Cys Thr Thr Gly Gly Ala Ala Cys Thr Cys Thr Gly Gly 
545                 550                 555                 560 


Cys Gly Cys Thr Cys Thr Gly Ala Cys Ala Ala Gly Cys Gly Gly Cys 
                565                 570                 575     


Gly Thr Gly Cys Ala Cys Ala Cys Ala Thr Thr Thr Cys Cys Ala Gly 
            580                 585                 590         


Cys Cys Gly Thr Gly Cys Thr Gly Cys Ala Ala Ala Gly Cys Ala Gly 
        595                 600                 605             


Cys Gly Gly Cys Cys Thr Gly Thr Ala Cys Thr Cys Thr Cys Thr Gly 
    610                 615                 620                 


Ala Gly Cys Ala Gly Cys Gly Thr Gly Gly Thr Cys Ala Cys Ala Gly 
625                 630                 635                 640 


Thr Gly Cys Cys Thr Ala Gly Cys Thr Cys Thr Ala Gly Cys Cys Thr 
                645                 650                 655     


Gly Gly Gly Cys Ala Cys Cys Ala Ala Gly Ala Cys Cys Thr Ala Cys 
            660                 665                 670         


Ala Cys Cys Thr Gly Thr Ala Ala Thr Gly Thr Gly Gly Ala Cys Cys 
        675                 680                 685             


Ala Cys Ala Ala Gly Cys Cys Thr Thr Cys Cys Ala Ala Cys Ala Cys 
    690                 695                 700                 


Cys Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala Gly Cys Gly Cys 
705                 710                 715                 720 


Gly Thr Gly Gly Ala Ala Thr Cys Thr Ala Ala Gly Thr Ala Cys Gly 
                725                 730                 735     


Gly Cys Cys Cys Thr Cys Cys Thr Thr Gly Thr Cys Cys Thr Cys Cys 
            740                 745                 750         


Ala Thr Gly Thr Cys Cys Thr Gly Cys Ala Cys Cys Thr Gly Ala Gly 
        755                 760                 765             


Thr Thr Thr Cys Thr Cys Gly Gly Cys Gly Gly Ala Cys Cys Cys Thr 
    770                 775                 780                 


Cys Cys Gly Thr Gly Thr Thr Cys Cys Thr Gly Thr Thr Thr Cys Cys 
785                 790                 795                 800 


Thr Cys Cys Ala Ala Ala Gly Cys Cys Thr Ala Ala Gly Gly Ala Cys 
                805                 810                 815     


Ala Cys Cys Cys Thr Gly Ala Thr Gly Ala Thr Cys Ala Gly Cys Ala 
            820                 825                 830         


Gly Ala Ala Cys Cys Cys Cys Thr Gly Ala Ala Gly Thr Gly Ala Cys 
        835                 840                 845             


Cys Thr Gly Cys Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly Ala Cys 
    850                 855                 860                 


Gly Thr Gly Thr Cys Cys Cys Ala Ala Gly Ala Gly Gly Ala Thr Cys 
865                 870                 875                 880 


Cys Thr Gly Ala Gly Gly Thr Gly Cys Ala Gly Thr Thr Cys Ala Ala 
                885                 890                 895     


Thr Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys 
            900                 905                 910         


Gly Thr Gly Gly Ala Ala Gly Thr Gly Cys Ala Cys Ala Ala Cys Gly 
        915                 920                 925             


Cys Cys Ala Ala Gly Ala Cys Cys Ala Ala Gly Cys Cys Thr Ala Gly 
    930                 935                 940                 


Ala Gly Ala Gly Gly Ala Ala Cys Ala Gly Thr Thr Cys Ala Ala Cys 
945                 950                 955                 960 


Ala Gly Cys Ala Cys Cys Thr Ala Cys Ala Gly Ala Gly Thr Gly Gly 
                965                 970                 975     


Thr Gly Thr Cys Cys Gly Thr Gly Cys Thr Gly Ala Cys Ala Gly Thr 
            980                 985                 990         


Gly Cys Thr Gly Cys Ala Cys Cys  Ala Gly Gly Ala Thr  Thr Gly Gly 
        995                 1000                 1005             


Cys Thr  Gly Ala Ala Cys Gly  Gly Cys Ala Ala Ala  Gly Ala Gly 
    1010                 1015                 1020             


Thr Ala  Cys Ala Ala Gly Thr  Gly Cys Ala Ala Gly  Gly Thr Gly 
    1025                 1030                 1035             


Thr Cys  Cys Ala Ala Cys Ala  Ala Gly Gly Gly Cys  Cys Thr Gly 
    1040                 1045                 1050             


Cys Cys  Thr Ala Gly Cys Ala  Gly Cys Ala Thr Cys  Gly Ala Gly 
    1055                 1060                 1065             


Ala Ala  Ala Ala Cys Cys Ala  Thr Cys Ala Gly Cys  Ala Ala Gly 
    1070                 1075                 1080             


Gly Cys  Cys Ala Ala Gly Gly  Gly Cys Cys Ala Gly  Cys Cys Ala 
    1085                 1090                 1095             


Ala Gly  Ala Gly Ala Ala Cys  Cys Cys Cys Ala Gly  Gly Thr Gly 
    1100                 1105                 1110             


Thr Ala  Cys Ala Cys Ala Cys  Thr Gly Cys Cys Thr  Cys Cys Ala 
    1115                 1120                 1125             


Ala Gly  Cys Cys Ala Ala Gly  Ala Gly Gly Ala Ala  Ala Thr Gly 
    1130                 1135                 1140             


Ala Cys  Cys Ala Ala Gly Ala  Ala Cys Cys Ala Gly  Gly Thr Gly 
    1145                 1150                 1155             


Thr Cys  Cys Cys Thr Gly Ala  Cys Cys Thr Gly Cys  Cys Thr Cys 
    1160                 1165                 1170             


Gly Thr  Gly Ala Ala Gly Gly  Gly Cys Thr Thr Cys  Thr Ala Cys 
    1175                 1180                 1185             


Cys Cys  Thr Thr Cys Cys Gly  Ala Thr Ala Thr Cys  Gly Cys Cys 
    1190                 1195                 1200             


Gly Thr  Gly Gly Ala Ala Thr  Gly Gly Gly Ala Gly  Ala Gly Cys 
    1205                 1210                 1215             


Ala Ala  Thr Gly Gly Ala Cys  Ala Gly Cys Cys Cys  Gly Ala Gly 
    1220                 1225                 1230             


Ala Ala  Cys Ala Ala Cys Thr  Ala Cys Ala Ala Gly  Ala Cys Ala 
    1235                 1240                 1245             


Ala Cys  Cys Cys Cys Thr Cys  Cys Thr Gly Thr Gly  Cys Thr Gly 
    1250                 1255                 1260             


Gly Ala  Cys Ala Gly Cys Gly  Ala Cys Gly Gly Cys  Thr Cys Ala 
    1265                 1270                 1275             


Thr Thr  Cys Thr Thr Cys Cys  Thr Gly Thr Ala Cys  Ala Gly Cys 
    1280                 1285                 1290             


Ala Gly  Ala Cys Thr Gly Ala  Cys Cys Gly Thr Gly  Gly Ala Cys 
    1295                 1300                 1305             


Ala Ala  Gly Ala Gly Cys Ala  Gly Ala Thr Gly Gly  Cys Ala Ala 
    1310                 1315                 1320             


Gly Ala  Gly Gly Gly Cys Ala  Ala Cys Gly Thr Gly  Thr Thr Cys 
    1325                 1330                 1335             


Thr Cys  Cys Thr Gly Cys Ala  Gly Cys Gly Thr Gly  Ala Thr Gly 
    1340                 1345                 1350             


Cys Ala  Cys Gly Ala Gly Gly  Cys Cys Cys Thr Gly  Cys Ala Cys 
    1355                 1360                 1365             


Ala Ala  Cys Cys Ala Cys Thr  Ala Cys Ala Cys Cys  Cys Ala Gly 
    1370                 1375                 1380             


Ala Ala  Gly Thr Cys Thr Cys  Thr Gly Thr Cys Cys  Cys Thr Gly 
    1385                 1390                 1395             


Thr Cys  Thr Cys Thr Gly Gly  Gly Cys Ala Ala Gly  Thr Gly Ala 
    1400                 1405                 1410             


Thr Gly  Ala 
    1415     


<210>  50
<211>  1416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized M2 antibody

<400>  50

Ala Thr Gly Gly Ala Ala Thr Thr Thr Thr Gly Gly Cys Thr Gly Ala 
1               5                   10                  15      


Gly Cys Thr Gly Gly Gly Thr Gly Thr Thr Cys Cys Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Cys Cys Ala Thr Cys Cys Thr Gly Ala Ala Ala Gly Gly Cys 
        35                  40                  45              


Gly Thr Gly Cys Ala Gly Thr Gly Cys Gly Ala Ala Gly Thr Thr Cys 
    50                  55                  60                  


Ala Gly Cys Thr Gly Cys Ala Gly Cys Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Cys Gly Cys Cys Gly Ala Ala Gly Thr Gly Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Cys Cys Thr Gly Gly Cys Gly Cys Cys Ala Cys Cys Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Cys Thr Gly Ala Gly Cys Thr Gly Thr Ala Cys Cys Gly Cys 
        115                 120                 125             


Cys Ala Gly Cys Gly Gly Cys Thr Thr Cys Ala Ala Cys Ala Thr Cys 
    130                 135                 140                 


Ala Ala Gly Gly Ala Cys Gly Ala Cys Thr Ala Cys Cys Thr Gly Cys 
145                 150                 155                 160 


Ala Cys Thr Gly Gly Gly Thr Cys Cys Gly Ala Cys Ala Gly Gly Cys 
                165                 170                 175     


Cys Cys Cys Thr Gly Ala Ala Cys Ala Ala Gly Gly Ala Cys Thr Gly 
            180                 185                 190         


Gly Ala Ala Thr Gly Gly Ala Thr Cys Gly Gly Cys Ala Gly Ala Ala 
        195                 200                 205             


Thr Cys Gly Ala Cys Cys Cys Cys Gly Cys Cys Ala Ala Cys Gly Gly 
    210                 215                 220                 


Cys Ala Ala Cys Ala Cys Cys Ala Ala Ala Thr Ala Cys Gly Cys Cys 
225                 230                 235                 240 


Cys Cys Thr Ala Ala Gly Thr Thr Cys Cys Ala Gly Gly Ala Cys Cys 
                245                 250                 255     


Gly Gly Gly Cys Cys Ala Cys Cys Ala Thr Cys Ala Cys Ala Gly Cys 
            260                 265                 270         


Cys Gly Ala Cys Ala Cys Cys Thr Cys Thr Ala Cys Ala Ala Ala Thr 
        275                 280                 285             


Ala Cys Cys Gly Cys Cys Thr Ala Cys Cys Thr Gly Gly Ala Ala Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Cys Cys Thr Gly Ala Gly Ala Ala Gly 
305                 310                 315                 320 


Cys Gly Ala Gly Gly Ala Cys Ala Cys Cys Gly Cys Cys Gly Thr Gly 
                325                 330                 335     


Thr Ala Cys Thr Ala Thr Thr Gly Cys Gly Cys Cys Gly Cys Cys Ala 
            340                 345                 350         


Gly Ala Thr Thr Cys Gly Gly Cys Thr Ala Cys Thr Thr Cys Thr Ala 
        355                 360                 365             


Cys Gly Gly Cys Ala Gly Cys Ala Gly Cys Thr Thr Thr Thr Ala Cys 
    370                 375                 380                 


Gly Cys Cys Gly Thr Gly Gly Cys Cys Thr Ala Thr Thr Gly Gly Gly 
385                 390                 395                 400 


Gly Ala Cys Ala Gly Gly Gly Cys Ala Cys Cys Cys Thr Gly Gly Thr 
                405                 410                 415     


Thr Ala Cys Ala Gly Thr Gly Thr Cys Cys Thr Cys Thr Gly Cys Cys 
            420                 425                 430         


Ala Gly Cys Ala Cys Ala Ala Ala Gly Gly Gly Cys Cys Cys Cys Thr 
        435                 440                 445             


Cys Cys Gly Thr Gly Thr Thr Thr Cys Cys Thr Cys Thr Gly Gly Cys 
    450                 455                 460                 


Thr Cys Cys Thr Thr Gly Thr Ala Gly Cys Ala Gly Ala Ala Gly Cys 
465                 470                 475                 480 


Ala Cys Cys Ala Gly Cys Gly Ala Gly Thr Cys Thr Ala Cys Ala Gly 
                485                 490                 495     


Cys Cys Gly Cys Thr Cys Thr Gly Gly Gly Cys Thr Gly Thr Cys Thr 
            500                 505                 510         


Gly Gly Thr Cys Ala Ala Gly Gly Ala Cys Thr Ala Cys Thr Thr Thr 
        515                 520                 525             


Cys Cys Cys Gly Ala Gly Cys Cys Thr Gly Thr Gly Ala Cys Cys Gly 
    530                 535                 540                 


Thr Gly Thr Cys Cys Thr Gly Gly Ala Ala Thr Ala Gly Cys Gly Gly 
545                 550                 555                 560 


Ala Gly Cys Ala Cys Thr Gly Ala Cys Ala Ala Gly Cys Gly Gly Cys 
                565                 570                 575     


Gly Thr Gly Cys Ala Cys Ala Cys Cys Thr Thr Thr Cys Cys Ala Gly 
            580                 585                 590         


Cys Thr Gly Thr Gly Cys Thr Gly Cys Ala Ala Ala Gly Cys Ala Gly 
        595                 600                 605             


Cys Gly Gly Cys Cys Thr Gly Thr Ala Cys Thr Cys Thr Cys Thr Gly 
    610                 615                 620                 


Ala Gly Cys Ala Gly Cys Gly Thr Gly Gly Thr Cys Ala Cys Ala Gly 
625                 630                 635                 640 


Thr Gly Cys Cys Thr Ala Gly Cys Thr Cys Thr Ala Gly Cys Cys Thr 
                645                 650                 655     


Gly Gly Gly Cys Ala Cys Cys Ala Ala Gly Ala Cys Cys Thr Ala Cys 
            660                 665                 670         


Ala Cys Cys Thr Gly Thr Ala Ala Thr Gly Thr Gly Gly Ala Cys Cys 
        675                 680                 685             


Ala Cys Ala Ala Gly Cys Cys Thr Thr Cys Cys Ala Ala Cys Ala Cys 
    690                 695                 700                 


Cys Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala Gly Cys Gly Cys 
705                 710                 715                 720 


Gly Thr Gly Gly Ala Ala Thr Cys Thr Ala Ala Gly Thr Ala Cys Gly 
                725                 730                 735     


Gly Cys Cys Cys Thr Cys Cys Thr Thr Gly Thr Cys Cys Thr Cys Cys 
            740                 745                 750         


Ala Thr Gly Thr Cys Cys Thr Gly Cys Thr Cys Cys Ala Gly Ala Gly 
        755                 760                 765             


Thr Thr Thr Cys Thr Cys Gly Gly Cys Gly Gly Ala Cys Cys Cys Thr 
    770                 775                 780                 


Cys Thr Gly Thr Gly Thr Thr Cys Cys Thr Gly Thr Thr Thr Cys Cys 
785                 790                 795                 800 


Thr Cys Cys Ala Ala Ala Gly Cys Cys Thr Ala Ala Gly Gly Ala Cys 
                805                 810                 815     


Ala Cys Cys Cys Thr Gly Ala Thr Gly Ala Thr Cys Ala Gly Cys Ala 
            820                 825                 830         


Gly Ala Ala Cys Cys Cys Cys Thr Gly Ala Ala Gly Thr Gly Ala Cys 
        835                 840                 845             


Cys Thr Gly Cys Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly Ala Cys 
    850                 855                 860                 


Gly Thr Gly Thr Cys Cys Cys Ala Ala Gly Ala Gly Gly Ala Thr Cys 
865                 870                 875                 880 


Cys Thr Gly Ala Gly Gly Thr Gly Cys Ala Gly Thr Thr Cys Ala Ala 
                885                 890                 895     


Thr Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys 
            900                 905                 910         


Gly Thr Gly Gly Ala Ala Gly Thr Gly Cys Ala Cys Ala Ala Cys Gly 
        915                 920                 925             


Cys Cys Ala Ala Gly Ala Cys Cys Ala Ala Gly Cys Cys Thr Ala Gly 
    930                 935                 940                 


Ala Gly Ala Gly Gly Ala Ala Cys Ala Gly Thr Thr Cys Ala Ala Cys 
945                 950                 955                 960 


Ala Gly Cys Ala Cys Cys Thr Ala Cys Ala Gly Ala Gly Thr Gly Gly 
                965                 970                 975     


Thr Gly Thr Cys Cys Gly Thr Gly Cys Thr Gly Ala Cys Cys Gly Thr 
            980                 985                 990         


Gly Cys Thr Gly Cys Ala Cys Cys  Ala Gly Gly Ala Thr  Thr Gly Gly 
        995                 1000                 1005             


Cys Thr  Gly Ala Ala Cys Gly  Gly Cys Ala Ala Ala  Gly Ala Gly 
    1010                 1015                 1020             


Thr Ala  Cys Ala Ala Gly Thr  Gly Cys Ala Ala Gly  Gly Thr Gly 
    1025                 1030                 1035             


Thr Cys  Cys Ala Ala Cys Ala  Ala Gly Gly Gly Cys  Cys Thr Gly 
    1040                 1045                 1050             


Cys Cys  Thr Ala Gly Cys Ala  Gly Cys Ala Thr Cys  Gly Ala Gly 
    1055                 1060                 1065             


Ala Ala  Ala Ala Cys Cys Ala  Thr Cys Ala Gly Cys  Ala Ala Gly 
    1070                 1075                 1080             


Gly Cys  Cys Ala Ala Gly Gly  Gly Cys Cys Ala Gly  Cys Cys Ala 
    1085                 1090                 1095             


Ala Gly  Ala Gly Ala Ala Cys  Cys Cys Cys Ala Gly  Gly Thr Gly 
    1100                 1105                 1110             


Thr Ala  Cys Ala Cys Ala Cys  Thr Gly Cys Cys Thr  Cys Cys Ala 
    1115                 1120                 1125             


Ala Gly  Cys Cys Ala Ala Gly  Ala Gly Gly Ala Ala  Ala Thr Gly 
    1130                 1135                 1140             


Ala Cys  Cys Ala Ala Gly Ala  Ala Cys Cys Ala Gly  Gly Thr Gly 
    1145                 1150                 1155             


Thr Cys  Cys Cys Thr Gly Ala  Cys Cys Thr Gly Cys  Cys Thr Cys 
    1160                 1165                 1170             


Gly Thr  Gly Ala Ala Gly Gly  Gly Cys Thr Thr Cys  Thr Ala Cys 
    1175                 1180                 1185             


Cys Cys  Thr Thr Cys Cys Gly  Ala Thr Ala Thr Cys  Gly Cys Cys 
    1190                 1195                 1200             


Gly Thr  Gly Gly Ala Ala Thr  Gly Gly Gly Ala Gly  Ala Gly Cys 
    1205                 1210                 1215             


Ala Ala  Thr Gly Gly Ala Cys  Ala Gly Cys Cys Cys  Gly Ala Gly 
    1220                 1225                 1230             


Ala Ala  Cys Ala Ala Cys Thr  Ala Cys Ala Ala Gly  Ala Cys Ala 
    1235                 1240                 1245             


Ala Cys  Cys Cys Cys Thr Cys  Cys Thr Gly Thr Gly  Cys Thr Gly 
    1250                 1255                 1260             


Gly Ala  Cys Ala Gly Cys Gly  Ala Cys Gly Gly Cys  Thr Cys Ala 
    1265                 1270                 1275             


Thr Thr  Cys Thr Thr Cys Cys  Thr Gly Thr Ala Cys  Ala Gly Cys 
    1280                 1285                 1290             


Ala Gly  Ala Cys Thr Gly Ala  Cys Cys Gly Thr Gly  Gly Ala Cys 
    1295                 1300                 1305             


Ala Ala  Gly Ala Gly Cys Ala  Gly Ala Thr Gly Gly  Cys Ala Ala 
    1310                 1315                 1320             


Gly Ala  Gly Gly Gly Cys Ala  Ala Cys Gly Thr Gly  Thr Thr Cys 
    1325                 1330                 1335             


Thr Cys  Cys Thr Gly Cys Ala  Gly Cys Gly Thr Gly  Ala Thr Gly 
    1340                 1345                 1350             


Cys Ala  Cys Gly Ala Gly Gly  Cys Cys Cys Thr Gly  Cys Ala Cys 
    1355                 1360                 1365             


Ala Ala  Cys Cys Ala Cys Thr  Ala Cys Ala Cys Cys  Cys Ala Gly 
    1370                 1375                 1380             


Ala Ala  Gly Thr Cys Thr Cys  Thr Gly Ala Gly Cys  Cys Thr Gly 
    1385                 1390                 1395             


Thr Cys  Thr Cys Thr Gly Gly  Gly Cys Ala Ala Gly  Thr Gly Ala 
    1400                 1405                 1410             


Thr Gly  Ala 
    1415     


