                         SEQUENCE LISTING

<110>  BIOVENTURES, LLC
       EOFF, Robert
       PENTHALA, Narsimha
       CROOKS, Peter
 
<120>  INDOLE MOLECULES AND USE THEREOF IN THE INHIBITION OF DNA 
       POLYMERASES

<130>  052592-640230

<150>  US 62/792,226
<151>  2019-01-14

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  1

Lys Gly Ser Arg Phe Tyr Gly Asn Glu Leu Lys Lys Glu 
1               5                   10              


<210>  2
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  2

Lys Thr Glu Ile Asp Ala Asp Phe Pro His Pro Leu Arg Leu Arg Leu 
1               5                   10                  15      


<210>  3
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  3

Lys Ala Gly Met Glu Gly Leu Asp Lys Glu Lys Ile 
1               5                   10          


<210>  4
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  4

Lys Ala Gly Met Glu Gly Leu Asp Lys Glu Lys Ile Asn Lys Ile 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Ile Asn Lys Ile Ile Met Glu Ala Thr Lys Gly Ser Arg Phe 
1               5                   10                  15  


<210>  6
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  6

Lys Gly Ser Arg Phe Tyr Gly Asn Glu Leu Lys Lys Glu 
1               5                   10              


<210>  7
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  7

Arg Phe Tyr Gly Asn Glu Leu Lys Lys Glu Lys Gln 
1               5                   10          


<210>  8
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Glu Lys Gln Val Asn Gln Arg Ile Glu Asn Met Met Gln Gln Lys 
1               5                   10                  15      


Ala 
    


<210>  9
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  9

Lys Gln Val Asn Gln Arg Ile Glu Asn Met Met Gln Gln Lys Ala 
1               5                   10                  15  


<210>  10
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  10

Arg Ile Glu Asn Met Met Gln Gln Lys Ala Gln Ile Thr Ser Gln Gln 
1               5                   10                  15      


Leu Arg Lys 
            


<210>  11
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  11

Lys Ala Gln Ile Thr Ser Gln Gln Leu Arg Lys Ala 
1               5                   10          


<210>  12
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Lys Ala Gln Leu Gln Val Asp Arg Phe Ala Met Glu Leu Glu Gln 
1               5                   10                  15      


Ser Arg Asn 
            


<210>  13
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Asn Leu Ser Asn Thr Ile Val His Ile Asp Met Asp Ala Phe Tyr 
1               5                   10                  15      


Ala Ala Val Glu Met Arg Asp 
            20              


<210>  14
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  14

Arg Asn Leu Ser Asn Thr Ile Val His Ile Asp Met Asp Ala Phe Tyr 
1               5                   10                  15      


Ala Ala Val Glu Met Arg Asp Asn Pro Glu Leu Lys Asp 
            20                  25                  


<210>  15
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Asp Asn Pro Glu Leu Lys Asp Lys Pro Ile Ala Val Gly Ser Met 
1               5                   10                  15      


Ser Met Leu Ser Thr Ser Asn Tyr His Ala Arg Arg 
            20                  25              


<210>  16
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  16

Lys Asp Lys Pro Ile Ala Val Gly Ser Met Ser Met Leu Ser Thr Ser 
1               5                   10                  15      


Asn Tyr His Ala Arg Arg Phe 
            20              


<210>  17
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Arg Phe Gly Val Arg Ala Ala Met Pro Gly Phe Ile Ala Lys Arg 
1               5                   10                  15      


<210>  18
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  18

Lys Arg Leu Pro Gln Leu Ile Ile Val Pro Pro Asn Phe Asp Lys Tyr 
1               5                   10                  15      


<210>  19
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  19

Lys Arg Leu Pro Gln Leu Ile Ile Val Pro Pro Asn Phe Asp Lys Tyr 
1               5                   10                  15      


Arg Ala 
        


<210>  20
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  20

Lys Glu Val Lys Glu Ile Leu Ala Asp Tyr Asp Pro Asn Phe Met Ala 
1               5                   10                  15      


Met Ser Leu Asp Glu Ala Tyr Leu Asn Ile Thr Lys His 
            20                  25                  


<210>  21
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  21

Lys Glu Ile Leu Ala Asp Tyr Asp Pro Asn Phe Met Ala Met Ser Leu 
1               5                   10                  15      


Asp Glu Ala Tyr Leu Asn Ile Thr Lys His 
            20                  25      


<210>  22
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  22

Arg Gln Asn Trp Pro Glu Asp Lys Arg Arg Tyr 
1               5                   10      


<210>  23
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  23

Arg Tyr Phe Ile Lys Met Gly Ser Ser Val Glu Asn Asp Asn Pro Gly 
1               5                   10                  15      


Lys Glu 
        


<210>  24
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  24

Lys Met Gly Ser Ser Val Glu Asn Asp Asn Pro Gly Lys Glu Val Asn 
1               5                   10                  15      


Lys Leu 
        


<210>  25
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  25

Lys Glu Val Asn Lys Leu Ser Glu His Glu Arg Ser 
1               5                   10          


<210>  26
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  26

Arg Ser Ile Ser Pro Leu Leu Phe Glu Glu Ser Pro Ser Asp Val Gln 
1               5                   10                  15      


Pro Pro Gly Asp Pro Phe Gln Val Asn Phe Glu Glu Gln Asn Asn Pro 
            20                  25                  30          


Gln Ile Leu Gln Asn Ser Val Val Phe Gly Thr Ser Ala Gln Glu Val 
        35                  40                  45              


Val Lys Glu 
    50      


<210>  27
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  27

Arg Phe Arg Ile Glu Gln Lys Thr Thr Leu Thr Ala Ser Ala Gly Ile 
1               5                   10                  15      


Ala Pro Asn Thr Met Leu Ala Lys Val 
            20                  25  


<210>  28
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  28

Lys Thr Thr Leu Thr Ala Ser Ala Gly Ile Ala Pro Asn Thr Met Leu 
1               5                   10                  15      


Ala Lys Val 
            


<210>  29
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  29

Lys Thr Thr Leu Thr Ala Ser Ala Gly Ile Ala Pro Asn Thr Met Leu 
1               5                   10                  15      


Ala Lys Val Ser Asp Lys Asn 
            20              


<210>  30
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  30

Lys Val Ser Asp Lys Asn Lys Pro Asn Gly Gln Tyr Gln Ile Leu Pro 
1               5                   10                  15      


Asn Arg Gln 
            


<210>  31
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  31

Lys Asn Lys Pro Asn Gly Gln Tyr Gln Ile Leu Pro Asn Arg Gln 
1               5                   10                  15  


<210>  32
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  32

Arg Gln Ala Val Met Asp Phe Ile Lys Asp Leu Pro Ile Arg Lys Val 
1               5                   10                  15      


<210>  33
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  33

Arg Lys Val Ser Gly Ile Gly Lys Val Thr Glu Lys Met 
1               5                   10              


<210>  34
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  34

Lys Val Ser Gly Ile Gly Lys Val Thr Glu Lys Met 
1               5                   10          


<210>  35
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  35

Lys Met Leu Lys Ala Leu Gly Ile Ile Thr Thr Glu Leu Tyr Gln Gln 
1               5                   10                  15      


Arg Ala 
        


<210>  36
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  36

Lys Ala Leu Gly Ile Ile Thr Thr Glu Leu Tyr Gln Gln Arg Ala 
1               5                   10                  15  


<210>  37
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  37

Arg Ala Leu Leu Ser Leu Leu Phe Ser Glu Thr Ser Trp His Tyr Phe 
1               5                   10                  15      


Leu His Ile Ser Leu Gly Leu Gly Ser Thr His Leu Thr Arg Asp 
            20                  25                  30      


<210>  38
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  38

Arg Asp Gly Glu Arg Lys Ser Met Ser Val Glu Arg Thr 
1               5                   10              


<210>  39
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  39

Arg Lys Ser Met Ser Val Glu Arg Thr 
1               5                   


<210>  40
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  40

Arg Thr Phe Ser Glu Ile Asn Lys Ala Glu Glu Gln Tyr Ser Leu Gln 
1               5                   10                  15      


Glu Leu Ser Glu Leu Ala Gln Asp Leu Gln Lys Glu 
            20                  25              


<210>  41
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  41

Lys Ala Glu Glu Gln Tyr Ser Leu Gln Glu Leu Ser Glu Leu Ala Gln 
1               5                   10                  15      


Asp Leu Gln Lys Glu 
            20      


<210>  42
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  42

Arg Leu Lys Gly Arg Thr Val Thr Ile Lys Leu Lys Asn Val Asn Phe 
1               5                   10                  15      


Glu Val Lys Thr 
            20  


<210>  43
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  43

Lys Gly Arg Thr Val Thr Ile Lys Leu 
1               5                   


<210>  44
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  44

Arg Thr Val Thr Ile Lys Leu Lys Asn Val Asn Phe Glu Val Lys Thr 
1               5                   10                  15      


<210>  45
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  45

Arg Thr Val Thr Ile Lys Leu Lys Asn Val Asn Phe Glu Val Lys Thr 
1               5                   10                  15      


Arg Ala 
        


<210>  46
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  46

Lys Leu Lys Asn Val Asn Phe Glu Val Lys Thr 
1               5                   10      


<210>  47
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  47

Lys Thr Arg Ala Ser Thr Val Ser Ser Val Val Ser Thr Ala Glu Glu 
1               5                   10                  15      


Ile Phe Ala Ile Ala Lys Glu 
            20              


<210>  48
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  48

Lys Thr Arg Ala Ser Thr Val Ser Ser Val Val Ser Thr Ala Glu Glu 
1               5                   10                  15      


Ile Phe Ala Ile Ala Lys Glu Leu Leu Lys Thr Glu Ile Asp Ala Asp 
            20                  25                  30          


Phe Pro His Pro Leu Arg Leu 
        35                  


<210>  49
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  49

Arg Ala Ser Thr Val Ser Ser Val Val Ser Thr Ala Glu Glu Ile Phe 
1               5                   10                  15      


Ala Ile Ala Lys Glu 
            20      


<210>  50
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  50

Arg Ala Ser Thr Val Ser Ser Val Val Ser Thr Ala Glu Glu Ile Phe 
1               5                   10                  15      


Ala Ile Ala Lys Glu Leu Leu Lys Thr 
            20                  25  


<210>  51
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  51

Arg Ala Ser Thr Val Ser Ser Val Val Ser Thr Ala Glu Glu Ile Phe 
1               5                   10                  15      


Ala Ile Ala Lys Glu Leu Leu Lys Thr Glu Ile Asp Ala Asp Phe Pro 
            20                  25                  30          


His Pro Leu Arg Leu 
        35          


<210>  52
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  52

Arg Ala Ser Thr Val Ser Ser Val Val Ser Thr Ala Glu Glu Ile Phe 
1               5                   10                  15      


Ala Ile Ala Lys Glu Leu Leu Lys Thr Glu Ile Asp Ala Asp Phe Pro 
            20                  25                  30          


His Pro Leu Arg Leu Arg Leu 
        35                  


<210>  53
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  53

Lys Thr Glu Ile Asp Ala Asp Phe Pro His Pro Leu Arg Leu Arg Leu 
1               5                   10                  15      


<210>  54
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  54

Arg Leu Arg Leu Met Gly Val Arg Ile 
1               5                   


<210>  55
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  55

Arg Leu Met Gly Val Arg Ile Ser Ser Phe Pro Asn Glu Glu Asp Arg 
1               5                   10                  15      


Lys 
    


<210>  56
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  56

Arg Leu Met Gly Val Arg Ile Ser Ser Phe Pro Asn Glu Glu Asp Arg 
1               5                   10                  15      


Lys His 
        


<210>  57
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  57

Arg Ile Ser Ser Phe Pro Asn Glu Glu Asp Arg Lys His 
1               5                   10              


<210>  58
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  58
ttttttttgc                                                              10


<210>  59
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  59
tcaccctcgt acgactctt                                                    19


<210>  60
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  60
gcaaaaaaaa aagagtcgta cgagggtga                                         29


