<110>    HWANG, IN HU

<120>    Composition for prevention, improvement or treatment of
         rheumatoid arthritis comprising tetraspanin-2 inhibitor

<130>    OP19-0050/PCT

<150>    KR 10-2019-0004869
<151>    2019-01-14

<150>    KR 10-2019-0020148
<151>    2019-02-20

<160>    31

<170>    KoPatentIn 3.0

<210>    1
<211>    227
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Homo sapiens tetraspanin-2 isoform 1 (NP_001760.1)


<400>    1
Met Pro Val Lys Gly Gly Thr Lys Cys Ile Lys Tyr Leu Leu Phe Gly
  1               5                  10                  15 

Phe Asn Phe Ile Phe Trp Leu Ala Gly Ile Ala Val Leu Ala Ile Gly
             20                  25                  30 

Leu Trp Leu Arg Phe Asp Ser Gln Thr Lys Ser Ile Phe Glu Gln Glu
         35                  40                  45 

Thr Asn Asn Asn Asn Ser Ser Phe Tyr Thr Gly Val Tyr Ile Leu Ile
     50                  55                  60 

Gly Ala Gly Ala Leu Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly
 65                  70                  75                  80 

Ala Val Gln Glu Ser Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu
                 85                  90                  95 

Leu Val Ile Phe Ala Ile Glu Ile Ala Ala Ala Ile Trp Gly Tyr Ser
            100                 105                 110 

His Lys Asp Glu Val Ile Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr
        115                 120                 125 

Tyr Asn Lys Leu Lys Thr Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys
    130                 135                 140 

Ala Ile His Tyr Ala Leu Asn Cys Cys Gly Leu Ala Gly Gly Val Glu
145                 150                 155                 160 

Gln Phe Ile Ser Asp Ile Cys Pro Lys Lys Asp Val Leu Glu Thr Phe
                165                 170                 175 

Thr Val Lys Ser Cys Pro Asp Ala Ile Lys Glu Val Phe Asp Asn Lys
            180                 185                 190 

Phe His Ile Ile Gly Ala Val Gly Ile Gly Ile Ala Val Val Met Ile
        195                 200                 205 

Phe Gly Met Ile Phe Ser Met Ile Leu Cys Cys Ala Ile Arg Arg Asn
    210                 215                 220 

Arg Glu Met
225        


<210>    2
<211>    158
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Homo sapiens tetraspanin-2 isoform 2 (NP_001317241.1)


<400>    2
Met Met Leu Val Gly Phe Leu Gly Cys Cys Gly Ala Val Gln Glu Ser
  1               5                  10                  15 

Gln Cys Met Leu Gly Leu Phe Phe Gly Phe Leu Leu Val Ile Phe Ala
             20                  25                  30 

Ile Glu Ile Ala Ala Ala Ile Gly Tyr Ser His Lys Asp Glu Val Ile
         35                  40                  45 

Lys Glu Val Gln Glu Phe Tyr Lys Asp Thr Tyr Asn Lys Leu Lys Thr
     50                  55                  60 

Lys Asp Glu Pro Gln Arg Glu Thr Leu Lys Ala Ile His Tyr Ala Leu
 65                  70                  75                  80 

Asn Cys Cys Gly Leu Ala Gly Gly Val Glu Gln Phe Ile Ser Asp Ile
                 85                  90                  95 

Cys Pro Lys Lys Asp Val Leu Glu Thr Phe Thr Val Lys Ser Cys Pro
            100                 105                 110 

Asp Ala Ile Lys Glu Val Phe Asp Asn Lys Phe His Ile Ile Gly Ala
        115                 120                 125 

Val Gly Ile Gly Ile Ala Val Val Met Ile Phe Gly Met Ile Phe Ser
    130                 135                 140 

Met Ile Leu Cys Cys Ala Ile Arg Arg Asn Arg Glu Met Val
145                 150                 155            


<210>    3
<211>    1320
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Homo sapiens tetraspanin-2 mRNA transcript variant 1


<400>    3
cttttcccgg cacatgcgca ccgcagcggg tcgcgcgccc taaggagtgg cactttttaa         60

aagtgcagcc ggagaccagc ctacagccgc ctgcatctgt atccagcgcc aggtcccgcc        120

agtcccagct gcgcgcgccc cccagtcccg cacccgttcg gcccaggcta agttagccct        180

caccatgccg gtcaaaggag gcaccaagtg catcaaatac ctgctgttcg gatttaactt        240

catcttctgg cttgccggga ttgctgtcct tgccattgga ctatggctcc gattcgactc        300

tcagaccaag agcatcttcg agcaagaaac taataataat aattccagct tctacacagg        360

agtctatatt ctgatcggag ccggcgccct catgatgctg gtgggcttcc tgggctgctg        420

cggggctgtg caggagtccc agtgcatgct gggactgttc ttcggcttcc tcttggtgat        480

attcgccatt gaaatagctg cggccatctg gggatattcc cacaaggatg aggtgattaa        540

ggaagtccag gagttttaca aggacaccta caacaagctg aaaaccaagg atgagcccca        600

gcgggaaacg ctgaaagcca tccactatgc gttgaactgc tgtggtttgg ctgggggcgt        660

ggaacagttt atctcagaca tctgccccaa gaaggacgta ctcgaaacct tcaccgtgaa        720

gtcctgtcct gatgccatca aagaggtctt cgacaataaa ttccacatca tcggcgcagt        780

gggcatcggc attgccgtgg tcatgatatt tggcatgatc ttcagtatga tcttgtgctg        840

tgctatccgc aggaaccgcg agatggtcta gagtcagctt acatccctga gcaggaaagt        900

ttacccatga agattggtgg gattttttgt ttgtttgttt tgttttgttt gttgtttgtt        960

gtttgttttt ttgccactaa ttttagtatt cattctgcat tgctagataa aagctgaagt       1020

tactttatgt ttgtctttta atgcttcatt caatattgac atttgtagtt gagcgggggg       1080

tttggtttgc tttggtttat attttttcag ttgtttgttt ttgcttgtta tattaagcag       1140

aaatcctgca atgaaaggta ctatatttgc tagactctag acaagatatt gtacataaaa       1200

gaattttttt gtctttaaat agatacaaat gtctatcaac tttaatcaag ttgtaactta       1260

tattgaagac aatttgatac ataataaaaa attatgacaa tgtcctggac tggtaaaaaa       1320

                                                                        1320


<210>    4
<211>    1437
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Homo sapiens tetraspanin-2 mRNA transcript variant 2


<400>    4
cttggggact gcccagccct cagctgtgtt attattcggt gataggtatt tgctaattac         60

ttccaaaagc ctcccatctg tcatcccacc cagactgcgc gcttctaatt cctcctaccc        120

cacatgctgt gcccaatgaa aagtatggtc agcgagcgaa ggtttgcaag gagacagacg        180

agggcgaaat taagccaggc ggcttccctt taaatcctcg caaagcagaa gggcccctca        240

ctctggcagc aggccttggc caaggggcct ttagccctga cgacccgggg aagagtctcc        300

caaagcagaa cgcccggtcc ggcgcccaga ccaaacgcgg gggaaccgga agggcgaggc        360

ctccaccttg ccgggattgc tgtccttgcc attggactat ggctccgatt cgactctcag        420

accaagagca tcttcgagca agaaactaat aataataatt ccagcttcta cacaggagtc        480

tatattctga tcggagccgg cgccctcatg atgctggtgg gcttcctggg ctgctgcggg        540

gctgtgcagg agtcccagtg catgctggga ctgttcttcg gcttcctctt ggtgatattc        600

gccattgaaa tagctgcggc catctgggga tattcccaca aggatgaggt gattaaggaa        660

gtccaggagt tttacaagga cacctacaac aagctgaaaa ccaaggatga gccccagcgg        720

gaaacgctga aagccatcca ctatgcgttg aactgctgtg gtttggctgg gggcgtggaa        780

cagtttatct cagacatctg ccccaagaag gacgtactcg aaaccttcac cgtgaagtcc        840

tgtcctgatg ccatcaaaga ggtcttcgac aataaattcc acatcatcgg cgcagtgggc        900

atcggcattg ccgtggtcat gatatttggc atgatcttca gtatgatctt gtgctgtgct        960

atccgcagga accgcgagat ggtctagagt cagcttacat ccctgagcag gaaagtttac       1020

ccatgaagat tggtgggatt ttttgtttgt ttgttttgtt ttgtttgttg tttgttgttt       1080

gtttttttgc cactaatttt agtattcatt ctgcattgct agataaaagc tgaagttact       1140

ttatgtttgt cttttaatgc ttcattcaat attgacattt gtagttgagc ggggggtttg       1200

gtttgctttg gtttatattt tttcagttgt ttgtttttgc ttgttatatt aagcagaaat       1260

ataaaagaat atttgctaga ctctagacaa gatattgtac aaggtactat cctgcaatga       1320

ttttttgtct ttaaatagat acaaatgtct atcaacttta atcaagttgt aacttatatt       1380

gaagacaatt tgatacataa taaaaaatta tgacaatgtc ctggactggt aaaaaaa          1437


<210>    5
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#1 for tetraspanin-2 mRNA, transcript variant 1


<400>    5
aagctttcat accaaatgtc a                                                   21


<210>    6
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#2 for tetraspanin-2 mRNA, transcript variant 1


<400>    6
aagaacaggc agtccatctc t                                                   21


<210>    7
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#3 for tetraspanin-2 mRNA, transcript variant 1


<400>    7
aagtcttcct ctggaaagag a                                                   21


<210>    8
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#4 for tetraspanin-2 mRNA, transcript variant 1


<400>    8
aagcaagaga tctggcagtt g                                                   21


<210>    9
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#5 for tetraspanin-2 mRNA, transcript variant 1


<400>    9
aaggagttat catcagagga c                                                   21


<210>    10
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#6 for tetraspanin-2 mRNA, transcript variant 1


<400>    10
aagagctttc agaaactttg a                                                   21


<210>    11
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#7 for tetraspanin-2 mRNA, transcript variant 1


<400>    11
aagaggctta caatgattac c                                                   21


<210>    12
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#8 for tetraspanin-2 mRNA, transcript variant 1


<400>    12
aagtctttga gtgtgcacta a                                                   21


<210>    13
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#9 for tetraspanin-2 mRNA, transcript variant 1


<400>    13
aaggcactga attaagactt c                                                   21


<210>    14
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#1 for tetraspanin-2 mRNA, transcript variant 2


<400>    14
aagctttcat accaaatgtc a                                                   21


<210>    15
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#2 for tetraspanin-2 mRNA, transcript variant 2


<400>    15
aagaacaggc agtccatctc t                                                   21


<210>    16
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#3 for tetraspanin-2 mRNA, transcript variant 2


<400>    16
aagtcttcct ctggaaagag a                                                   21


<210>    17
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#4 for tetraspanin-2 mRNA, transcript variant 2


<400>    17
aagcaagaga tctggcagtt g                                                   21


<210>    18
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#5 for tetraspanin-2 mRNA, transcript variant 2


<400>    18
aaggagttat catcagagga c                                                   21


<210>    19
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#6 for tetraspanin-2 mRNA, transcript variant 2


<400>    19
aagagctttc agaaactttg a                                                   21


<210>    20
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#7 for tetraspanin-2 mRNA, transcript variant 2


<400>    20
aagaggctta caatgattac c                                                   21


<210>    21
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#8 for tetraspanin-2 mRNA, transcript variant 2


<400>    21
aagtctttga gtgtgcacta a                                                   21


<210>    22
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#9 for tetraspanin-2 mRNA, transcript variant 2


<400>    22
aaggcactga attaagactt c                                                   21


<210>    23
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#1 for tetraspanin-2 mRNA, transcript variant 3


<400>    23
aagctttcat accaaatgtc a                                                   21


<210>    24
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#2 for tetraspanin-2 mRNA, transcript variant 3


<400>    24
aagaacaggc agtccatctc t                                                   21


<210>    25
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#3 for tetraspanin-2 mRNA, transcript variant 3


<400>    25
aagtcttcct ctggaaagag a                                                   21


<210>    26
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#4 for tetraspanin-2 mRNA, transcript variant 3


<400>    26
aagcaagaga tctggcagtt g                                                   21


<210>    27
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#5 for tetraspanin-2 mRNA, transcript variant 3


<400>    27
aaggagttat catcagagga c                                                   21


<210>    28
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#6 for tetraspanin-2 mRNA, transcript variant 3


<400>    28
aagagctttc agaaactttg a                                                   21


<210>    29
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#7 for tetraspanin-2 mRNA, transcript variant 3


<400>    29
aagaggctta caatgattac c                                                   21


<210>    30
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#8 for tetraspanin-2 mRNA, transcript variant 3


<400>    30
aagtctttga gtgtgcacta a                                                   21


<210>    31
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    siRNA#9 for tetraspanin-2 mRNA, transcript variant 3


<400>    31
aaggcactga attaagactt c                                                   21
