                         SEQUENCE LISTING

<110>  UCB Biopharma SRL
       Oxford University Innovation Limited
 
<120>  ANTIBODIES

<130>  N414848WO

<150>  GB 1900732.7
<151>  2019-01-18

<160>  405   

<170>  PatentIn version 3.5

<210>  1
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C heavy chain variable region

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Thr Ser Ser Ser Tyr Ile Tyr Tyr Ala Tyr Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Leu Gly Tyr Ser Tyr Gly Thr Asn Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  2
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C light chain variable region

<400>  2

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  3
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  040 heavy chain variable region

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Ile Thr Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Asn Ser Tyr Tyr Tyr His Ser Ser Gly Leu Leu Ile Arg Trp Asp 
            100                 105                 110         


Asp Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  4
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  040 light chain variable region

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Ser Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  5
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 heavy chain variable region

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Gly Phe Ser Ser Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Lys Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Ile Met Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Ala Gly Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Ile Val Leu Asn Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  6
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 light chain variable region

<400>  6

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Ser Asp Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  7
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 heavy chain variable region

<400>  7

Glu Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Asn 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Lys Met Gly Gly Tyr Gly Asp Tyr Trp His Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  8
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 light chain variable region

<400>  8

Glu Val Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Phe Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Arg Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Phe Tyr Tyr Cys Gln Gln Tyr Asn Asp Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  9
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C HCDR1

<400>  9

Gly Phe Thr Phe Ser Ser Tyr Asn Met Asn 
1               5                   10  


<210>  10
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C HCDR2

<400>  10

Ser Ile Thr Thr Ser Ser Ser Tyr Ile Tyr Tyr Ala Tyr Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C HCDR3

<400>  11

Phe Leu Gly Tyr Ser Tyr Gly Thr Asn Tyr Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  12
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C LCDR1

<400>  12

Arg Ser Ser Gln Ser Leu Leu His Ser Asp Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  13
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C LCDR2

<400>  13

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  14
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C LCDR3

<400>  14

Met Gln Ala Leu Gln Thr Leu Thr 
1               5               


<210>  15
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  040 HCDR1

<400>  15

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  16
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  040 HCDR2

<400>  16

Thr Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  040 HCDR3

<400>  17

Ser Tyr Tyr Tyr His Ser Ser Gly Leu Leu Ile Arg Trp Asp Asp Met 
1               5                   10                  15      


Asp Val 
        


<210>  18
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  040 LCDR1

<400>  18

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  040 LCDR2

<400>  19

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  040 LCDR3

<400>  20

Leu Gln His Ser Ser Tyr Pro Trp Thr 
1               5                   


<210>  21
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 HCDR1

<400>  21

Gly Phe Gly Phe Ser Ser Ala Trp Met Asn 
1               5                   10  


<210>  22
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 HCDR2

<400>  22

Arg Ile Lys Ser Lys Thr Asp Gly Gly Lys Thr Asp Tyr Ala Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210>  23
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 HCDR3

<400>  23

Arg Ile Val Leu Asn Gly Met Asp Val 
1               5                   


<210>  24
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 LCDR1

<400>  24

Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  


<210>  25
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 LCDR2

<400>  25

Ala Asn Asn Asn Arg Pro Ser 
1               5           


<210>  26
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 LCDR3

<400>  26

Gln Ser Tyr Asp Ser Arg Leu Ser Asp Gly Val Val 
1               5                   10          


<210>  27
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 HCDR1

<400>  27

Gly Gly Ser Phe Ser Gly Asn Tyr Trp Thr 
1               5                   10  


<210>  28
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 HCDR2

<400>  28

Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  29
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 HCDR3

<400>  29

Lys Met Gly Gly Tyr Gly Asp Tyr Trp His Trp Tyr Phe Asp Leu 
1               5                   10                  15  


<210>  30
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 LCDR1

<400>  30

Arg Ala Ser Gln Ser Leu Phe Thr Asn Leu Ala 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 LCDR2

<400>  31

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 LCDR3

<400>  32

Gln Gln Tyr Asn Asp Trp Pro Leu Thr 
1               5                   


<210>  33
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  6660 HCDR3

<400>  33

Thr Ala Gly Val Val Cys Leu His Gly Ser Ser Cys Val Gly Val 
1               5                   10                  15  


<210>  34
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  6669 HCDR3

<400>  34

Thr Thr Glu Val Val Gly Val 
1               5           


<210>  35
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  6670 HCDR3

<400>  35

Thr Thr Arg Val Ser Ala Pro Phe Asp Ile 
1               5                   10  


<210>  36
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  6666 HCDR3

<400>  36

Thr Thr Arg Trp Val Tyr Asn Gly Met Asp Val 
1               5                   10      


<210>  37
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  6667 HCDR3

<400>  37

Asn Thr Val Arg Ser Gly Ala Asp Tyr 
1               5                   


<210>  38
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  P7 HCDR3

<400>  38

Thr Thr Gly Gly Arg Asp Met Ala 
1               5               


<210>  39
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  105 HCDR3

<400>  39

Thr Thr Asn Phe Trp Ser Gly Arg Asp Tyr Met Asp Val 
1               5                   10              


<210>  40
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-14 HCDR3

<400>  40

Ile Pro Thr Ala Tyr Tyr Asp Tyr Val Trp Gly Ser Tyr Arg Ser Asp 
1               5                   10                  15      


Tyr 
    


<210>  41
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-4-D4 HCDR3

<400>  41

Thr Thr Arg Leu Thr Pro Asn Arg Leu Arg Trp Thr Gln Thr Glu Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Tyr Thr Met Asp Val 
            20                  


<210>  42
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  140 heavy junction

<400>  42

Cys Ala Arg His Phe His Tyr Tyr Asp Ser Ser Gly Ser Glu Thr Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  43
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  140 light junction

<400>  43

Cys Gln Ser Ala Asp Ser Asn Arg Thr Tyr Ser Asp Val Val Phe 
1               5                   10                  15  


<210>  44
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  142 heavy junction

<400>  44

Cys Ala Gly Gly Ser Ser Trp Leu Tyr Tyr Met Asp Val Trp 
1               5                   10                  


<210>  45
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  142 light junction

<400>  45

Cys Gln Gln Tyr Gly Ser Ser Lys Thr Phe 
1               5                   10  


<210>  46
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  6672 heavy junction

<400>  46

Cys Ala Arg Val Asn Val Lys Phe Gly Glu Leu Leu Pro Pro Tyr Tyr 
1               5                   10                  15      


Phe Asp Tyr Trp 
            20  


<210>  47
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  6672 light junction

<400>  47

Cys Ser Ser Tyr Thr Ser Ser Asn Ser Tyr Val Phe 
1               5                   10          


<210>  48
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  141 heavy junction

<400>  48

Cys Ala Arg Asp Ser Gln Glu Val Phe Gly Val Leu Ile Met Ala Tyr 
1               5                   10                  15      


Tyr Asp Tyr Tyr Tyr Met Asp Val Trp 
            20                  25  


<210>  49
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  141 light junction

<400>  49

Cys Gln Gln Tyr Asn Asn Arg Arg Thr Phe 
1               5                   10  


<210>  50
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  139 heavy junction

<400>  50

Cys Ala Arg Ala Leu Leu Val Pro Ala Ala Met Pro Trp Ser Val Leu 
1               5                   10                  15      


Phe Tyr Tyr Phe Gly Met Asp Val Trp 
            20                  25  


<210>  51
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  139 light junction

<400>  51

Cys Cys Ser Tyr Ala Gly Ser Ser Thr Phe Asn Tyr Val Phe 
1               5                   10                  


<210>  52
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  143 heavy junction

<400>  52

Cys Ala Arg Gly Gly His Tyr Cys Thr Asp Gly Val Cys Tyr Ser Leu 
1               5                   10                  15      


Pro Tyr Phe Met Asp Val Trp 
            20              


<210>  53
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  143 light junction

<400>  53

Cys Gln Gln Tyr Gly Ser Ser Leu Leu Thr Phe 
1               5                   10      


<210>  54
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  6659 heavy junction

<400>  54

Cys Thr Thr Val Gly Val His Ile Trp Asn Phe Gly Tyr Trp 
1               5                   10                  


<210>  55
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  6659 light junction

<400>  55

Cys Gln Ser Tyr Asp Ser Arg Leu Ser Asp Asn Met Ile Phe 
1               5                   10                  


<210>  56
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  6660 heavy junction

<400>  56

Cys Thr Ala Gly Val Val Cys Leu His Gly Ser Ser Cys Val Gly Val 
1               5                   10                  15      


Trp 
    


<210>  57
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  6660 light junction

<400>  57

Cys Gln Ser Tyr Asp Ser Arg Leu Arg Asp Phe Trp Val Phe 
1               5                   10                  


<210>  58
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  6664 heavy junction

<400>  58

Cys Thr Thr Gly Val Val Cys Leu Asp Arg Ser Ser Cys Val Gly Val 
1               5                   10                  15      


Trp 
    


<210>  59
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  6664 light junction

<400>  59

Cys Gln Ser Tyr Asp Ser Ser Leu Ser Asp Phe Trp Val Phe 
1               5                   10                  


<210>  60
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  6669 heavy junction

<400>  60

Cys Thr Thr Glu Val Val Gly Val Trp 
1               5                   


<210>  61
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  6669 light junction

<400>  61

Cys Gln Ser Tyr Asp Ser Ser Leu Arg Asp Phe Trp Val Phe 
1               5                   10                  


<210>  62
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  6655 heavy junction

<400>  62

Cys Ala Arg Glu Val Thr Met Ile Val Val Glu Trp Tyr Phe Asp Leu 
1               5                   10                  15      


Trp 
    


<210>  63
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  6655 light junction

<400>  63

Cys Gln Gln Tyr Gly Ser Ser Pro Pro Ile Thr Phe 
1               5                   10          


<210>  64
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  6661 heavy junction

<400>  64

Cys Ala Arg Glu Asn Leu Trp Phe Gly Glu Leu Leu Ser His Tyr Asp 
1               5                   10                  15      


Tyr Tyr Tyr Ala Met Asp Val Trp 
            20                  


<210>  65
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  6661 light junction

<400>  65

Cys Gly Thr Trp Asp Ser Ser Leu Ser Ala Tyr Val Phe 
1               5                   10              


<210>  66
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  6663 heavy junction

<400>  66

Cys Ala Lys Asp Ser Leu Trp Leu Gly Asp Leu Leu Gly Gly Asp Phe 
1               5                   10                  15      


Tyr Tyr Gly Met Asp Val Trp 
            20              


<210>  67
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  6663 light junction

<400>  67

Cys Cys Ser Tyr Ala Gly Ser Ser Pro Tyr Val Phe 
1               5                   10          


<210>  68
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  6650 heavy junction

<400>  68

Cys Ala Lys Glu Arg Ser Arg Ser Trp Tyr Thr Trp Ala Ser Gly Tyr 
1               5                   10                  15      


Phe Glu Tyr Trp 
            20  


<210>  69
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  6650 light junction

<400>  69

Cys Gln Gln Arg Ser Asn Trp Pro Arg Thr Phe 
1               5                   10      


<210>  70
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  6656 heavy junction

<400>  70

Cys Ala Arg Arg Tyr Phe Asp Trp Leu Leu Thr Pro Ile Asp Tyr Tyr 
1               5                   10                  15      


Gly Leu Gly Val Trp 
            20      


<210>  71
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  6656 light junction

<400>  71

Cys Met Gln Ala Leu Gln Thr Pro Gly Phe Thr Phe 
1               5                   10          


<210>  72
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  6654 heavy junction

<400>  72

Cys Ala Lys Asp Ile Leu Gly Gly Glu Phe Trp Ser Gly Ser Cys Ser 
1               5                   10                  15      


Gly Trp 
        


<210>  73
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  6654 light junction

<400>  73

Cys Gln Gln Ser Tyr Ser Ile Pro Tyr Thr Phe 
1               5                   10      


<210>  74
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  6652 heavy junction

<400>  74

Cys Ala Arg Gly Glu Glu Thr Ser Asp Ile Val Val Leu Pro Ala Asp 
1               5                   10                  15      


Ala Phe Asp Ile Trp 
            20      


<210>  75
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  6652 light junction

<400>  75

Cys Leu Gln His Asn Ser Tyr Pro Arg Thr Phe 
1               5                   10      


<210>  76
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  6653 heavy junction

<400>  76

Cys Ala Ser Pro Gly Ala Ile His Ser Ser Asp Trp Tyr Tyr Tyr Leu 
1               5                   10                  15      


Ala Met Asp Val Trp 
            20      


<210>  77
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  6653 light junction

<400>  77

Cys Gln Gln Tyr Asn Asn Trp Pro Pro Ile Thr Phe 
1               5                   10          


<210>  78
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  6651 heavy junction

<400>  78

Cys Ala Arg Val Glu Ser Trp Gln Leu Gly Ala Phe Asp Ile Trp 
1               5                   10                  15  


<210>  79
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  6651 light junction

<400>  79

Cys Gln Gln Tyr Asn Asp Trp Pro Arg Thr Phe 
1               5                   10      


<210>  80
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  6666 heavy junction

<400>  80

Cys Thr Thr Arg Trp Val Tyr Asn Gly Met Asp Val Trp 
1               5                   10              


<210>  81
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  6666 light junction

<400>  81

Cys Gln Ser Tyr Asp Ser Ser Leu Arg Asp Ser Val Val Phe 
1               5                   10                  


<210>  82
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  6670 heavy junction

<400>  82

Cys Thr Thr Arg Val Ser Ala Pro Phe Asp Ile Trp 
1               5                   10          


<210>  83
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  6670 light junction

<400>  83

Cys Gln Ser Tyr Asp Ser Arg Leu Arg Asp His Val Val Phe 
1               5                   10                  


<210>  84
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  6665 heavy junction

<400>  84

Cys Thr Thr Arg Trp Val Tyr Asn Gly Met Asp Val Trp 
1               5                   10              


<210>  85
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  6665 light junction

<400>  85

Cys Gln Ser Tyr Asp Ser Ser Leu Arg Asp Ser Val Val Phe 
1               5                   10                  


<210>  86
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  6667 heavy junction

<400>  86

Cys Asn Thr Val Arg Ser Gly Ala Asp Tyr Trp 
1               5                   10      


<210>  87
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  6667 light junction

<400>  87

Cys Gln Ser Tyr Asp Ser Arg Leu Ser Asp Asn Trp Val Phe 
1               5                   10                  


<210>  88
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  6668 heavy junction

<400>  88

Cys Ala Lys Asp Ile Gly Asn Tyr Glu Phe Trp Ser Gly Tyr Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  89
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  6668 light junction

<400>  89

Cys Gln Gln Tyr Asn Asn Trp Pro Pro Ala Phe 
1               5                   10      


<210>  90
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  176 heavy junction

<400>  90

Cys Ala Arg Gly Thr Met Ala Arg Gly Leu Ile Leu His Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val Trp 
            20  


<210>  91
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  176 light junction

<400>  91

Cys Ser Ser Tyr Ala Gly Ser Asn Asn Phe Tyr Val Phe 
1               5                   10              


<210>  92
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  040 heavy junction

<400>  92

Cys Ala Asn Ser Tyr Tyr Tyr His Ser Ser Gly Leu Leu Ile Arg Trp 
1               5                   10                  15      


Asp Asp Met Asp Val Trp 
            20          


<210>  93
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  040 light junction

<400>  93

Cys Leu Gln His Ser Ser Tyr Pro Trp Thr Phe 
1               5                   10      


<210>  94
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  18-1-D3 heavy junction

<400>  94

Cys Thr Thr Tyr Arg Glu Glu Gly Leu Asp Tyr Trp 
1               5                   10          


<210>  95
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  18-1-D3 light junction

<400>  95

Cys Gln Ser Pro Asp Ile Ser Gly Pro Tyr Val Val Phe 
1               5                   10              


<210>  96
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  P7 heavy junction

<400>  96

Cys Thr Thr Gly Gly Arg Asp Met Ala Trp 
1               5                   10  


<210>  97
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  P7 light junction

<400>  97

Cys Gln Ser Pro Asp Ile Ser Gly Pro Tyr Val Val Phe 
1               5                   10              


<210>  98
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  P6 heavy junction

<400>  98

Cys Ala Arg Asp Pro Leu Ser Asp Gly Phe Leu Ser Leu Ser Asn His 
1               5                   10                  15      


Phe Tyr Tyr Gly Met Asp Val Trp 
            20                  


<210>  99
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  P6 light junction

<400>  99

Cys Gln Gln Cys Gly Ser Ser Pro Pro Tyr Thr Phe 
1               5                   10          


<210>  100
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  18-1-D10 heavy junction

<400>  100

Cys Ala Arg Gly Ala Ser Ser Asp Pro Asn Tyr Tyr Tyr Ala Met Asp 
1               5                   10                  15      


Val Trp 
        


<210>  101
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  18-1-D10 light junction

<400>  101

Cys Gln Gln Ala Asn Ser Leu Pro Leu Thr Phe 
1               5                   10      


<210>  102
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  18-1-A9 heavy junction

<400>  102

Cys Ala Arg Leu Gly Gly Arg Val Val Lys Val Val His Ala Ile Trp 
1               5                   10                  15      


Phe Asp Pro Trp 
            20  


<210>  103
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  18-1-A9 light junction

<400>  103

Cys Gly Thr Trp Asp Asn Ser Pro Ile Phe 
1               5                   10  


<210>  104
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  19-2-12C heavy junction

<400>  104

Cys Thr Ala Asp Cys Val Leu Leu Trp Phe Gly Asp Leu Leu Tyr Cys 
1               5                   10                  15      


Gly Met Asp Val Trp 
            20      


<210>  105
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  19-2-12C light junction

<400>  105

Cys Gln His Tyr Gly Ser Ser Pro Thr Phe 
1               5                   10  


<210>  106
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  45-4-A5 heavy junction

<400>  106

Cys Ile Pro Pro Pro Met Val Arg Gly Val Thr Leu Asp Tyr Trp 
1               5                   10                  15  


<210>  107
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  45-4-A5 light junction

<400>  107

Cys Gln Ser Tyr Asp Ser Arg Leu Ser Asp His Trp Val Phe 
1               5                   10                  


<210>  108
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  45-4-B10 heavy junction

<400>  108

Cys Ala Arg Asp Pro Leu Ser Asp Gly Phe Leu Ser Leu Ser Asn His 
1               5                   10                  15      


Phe Tyr Tyr Gly Met Asp Val Trp 
            20                  


<210>  109
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  45-4-B10 light junction

<400>  109

Cys Gln Gln Tyr Asn Asp Trp Pro Arg Thr Phe 
1               5                   10      


<210>  110
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  116 heavy junction

<400>  110

Cys Ala Val Gly Phe Asp Ser Asn Gly Trp Ser Asn Trp 
1               5                   10              


<210>  111
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  116 light junction

<400>  111

Cys Gln Ser Gly Asp Ser Ser Gly Thr Tyr Pro Gly Val Val Ile 
1               5                   10                  15  


<210>  112
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  094 heavy junction

<400>  112

Cys Ala Arg Gly Arg Arg Glu Met Gln Leu Val Arg Gly Ser Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Tyr Met Asp Val Trp 
            20                  


<210>  113
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  094 light junction

<400>  113

Cys Gln Ala Trp Asp Ser Ser Thr Ser Leu Phe 
1               5                   10      


<210>  114
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  133 heavy junction

<400>  114

Cys Thr Arg Gly Arg Arg Glu Met Gln Leu Val Arg Gly Ser Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Tyr Met Asp Val Trp 
            20                  


<210>  115
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  133 light junction

<400>  115

Cys Gln Ala Trp Asp Ser Ser Thr Ser Leu Phe 
1               5                   10      


<210>  116
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  6535 heavy junction

<400>  116

Cys Ala Arg Ala Ser Tyr Cys Gly Gly Asp Cys Tyr Phe Leu Leu Ser 
1               5                   10                  15      


Ser Arg Phe Asp Tyr Trp 
            20          


<210>  117
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  6535 light junction

<400>  117

Cys Gln Val Trp His Ser Ser Ser Asp His Val Val Phe 
1               5                   10              


<210>  118
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  6673 heavy junction

<400>  118

Cys Ser Thr Arg Tyr Ser Ser Ala Trp Phe Asn Asp Tyr Trp 
1               5                   10                  


<210>  119
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  6673 light junction

<400>  119

Cys Gln Ser Tyr Asp Ser Ser Leu Arg Asp Asn Trp Val Phe 
1               5                   10                  


<210>  120
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  105 heavy junction

<400>  120

Cys Thr Thr Asn Phe Trp Ser Gly Arg Asp Tyr Met Asp Val Trp 
1               5                   10                  15  


<210>  121
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  105 light junction

<400>  121

Cys Gln Ser Tyr Asp Ser Ser Leu Arg Asp His Val Val Phe 
1               5                   10                  


<210>  122
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  132 heavy junction

<400>  122

Cys Thr Thr Gln Arg Gly Val Thr Asp Tyr Trp 
1               5                   10      


<210>  123
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  132 light junction

<400>  123

Cys Gln Ser Tyr Asp Ser Ser Leu Arg Asp Ser Cys Val Phe 
1               5                   10                  


<210>  124
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  121 heavy junction

<400>  124

Cys Ala Arg Glu Tyr Cys Ser Gly Gly Thr Cys Tyr Leu Asp Tyr Trp 
1               5                   10                  15      


<210>  125
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  121 light junction

<400>  125

Cys Gln Ala Trp Asp Ser Ser Thr Val Val Phe 
1               5                   10      


<210>  126
<211>  26
<212>  PRT
<213>  artificial sequence

<220>
<223>  125 heavy junction

<400>  126

Cys Ala Arg Val Arg Phe Cys Ser Gly Ala Ser Cys Ala Ser Val Tyr 
1               5                   10                  15      


Leu Leu Asp Leu Trp Tyr Phe Asp Leu Trp 
            20                  25      


<210>  127
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  125 light junction

<400>  127

Cys Gln Gln Leu Asp Ser Tyr Pro Leu Thr Phe 
1               5                   10      


<210>  128
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-3D heavy junction

<400>  128

Cys Ala Arg Ser Arg Tyr Gly Asp Phe Trp Ser Gly Tyr Cys Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  129
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-3D  light junction

<400>  129

Cys Gln Gln Tyr Gly Ser Ser Leu Pro Tyr Thr Phe 
1               5                   10          


<210>  130
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-7A heavy junction

<400>  130

Cys Ala Arg Asp Tyr Val Arg Trp Met Ala Thr Ile Gly Asp Ala Phe 
1               5                   10                  15      


Asp Ile Trp 
            


<210>  131
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-7A  light junction

<400>  131

Cys Ser Ser Tyr Ala Gly Ser Asn Asn Phe Asp Val Val Phe 
1               5                   10                  


<210>  132
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-9A heavy junction

<400>  132

Cys Ala Arg Pro Leu Ile Ala Thr Arg His Gly Arg Gly Thr Ser Trp 
1               5                   10                  15      


Tyr Phe Asp Leu Trp 
            20      


<210>  133
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-9A  light junction

<400>  133

Cys Gln Ser Tyr Asp Ser Ser Leu Ser Tyr Ile Phe 
1               5                   10          


<210>  134
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-1C heavy junction

<400>  134

Cys Ala Arg Val Arg Arg Pro Ile Met Val Arg Gly Val Asp Phe Asp 
1               5                   10                  15      


Tyr Trp 
        


<210>  135
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-1C  light junction

<400>  135

Cys Gln Gln Gly Tyr Ser Ile Leu Gly Ala Leu Thr Phe 
1               5                   10              


<210>  136
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-11D heavy junction

<400>  136

Cys Ala Arg Glu Asp Thr Gly Val Ala Trp Ala Pro Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val Trp 
            20  


<210>  137
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-11D  light junction

<400>  137

Cys Gln Gln Tyr Asn Asn Trp Pro Ala Arg Ala Phe 
1               5                   10          


<210>  138
<211>  26
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-4-D4 heavy junction

<400>  138

Cys Thr Thr Arg Leu Thr Pro Asn Arg Leu Arg Trp Thr Gln Thr Glu 
1               5                   10                  15      


Tyr Tyr Tyr Tyr Tyr Thr Met Asp Val Trp 
            20                  25      


<210>  139
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-4-D4 light junction

<400>  139

Cys Gln Ser Tyr Asp Ser Ser Arg Val Leu Phe 
1               5                   10      


<210>  140
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-7D heavy junction

<400>  140

Cys Ala Arg Ser Lys Trp Glu Leu Leu Trp Val Val Gly Thr Asn Phe 
1               5                   10                  15      


Tyr Tyr Gly Met Asp Val Trp 
            20              


<210>  141
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-7D light junction

<400>  141

Cys Gln Ser Tyr Asp Thr Ser Leu Gly Gly Ser Val Phe 
1               5                   10              


<210>  142
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-9C heavy junction

<400>  142

Cys Ala Arg Asp Gly Lys Arg Ile Thr Ile Ser Gly Val Leu Ile Pro 
1               5                   10                  15      


Leu Tyr Trp Phe Phe Asp Leu Trp 
            20                  


<210>  143
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-9C light junction

<400>  143

Cys Gln Gln Tyr Gly Ser Ser Ile Thr Phe 
1               5                   10  


<210>  144
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  6539 heavy junction

<400>  144

Cys Ala Arg Asp Gly Gly Arg Val Leu Leu Tyr Phe Gly Glu Ser Gly 
1               5                   10                  15      


Phe Asp Pro Trp 
            20  


<210>  145
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  6539 light junction

<400>  145

Cys Gln Gln Ala Asn Ser Phe Pro Leu Thr Phe 
1               5                   10      


<210>  146
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-10 heavy junction

<400>  146

Cys Ala Arg Asp Asp Phe Trp Ser Gly Ile Thr Trp 
1               5                   10          


<210>  147
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-10 light junction

<400>  147

Cys Gln Gln Tyr Asn Asn Trp Trp Thr Phe 
1               5                   10  


<210>  148
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9A heavy junction

<400>  148

Cys Ala Arg His Asp Ser Ser Gly Tyr Asp Ala Phe Asp Ile Trp 
1               5                   10                  15  


<210>  149
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9A light junction

<400>  149

Cys Gln Ser Ser Asp Ser Ser Ala Thr Tyr Val Val Phe 
1               5                   10              


<210>  150
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-7B heavy junction

<400>  150

Cys Ala Arg Asp Trp Leu His Ser Arg Ser Pro Arg Ala Gly Asn Trp 
1               5                   10                  15      


Phe Asp Pro Trp 
            20  


<210>  151
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-7B light junction

<400>  151

Cys Gln Gln Tyr Gly Gly Ser Pro Thr Phe 
1               5                   10  


<210>  152
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  6537 heavy junction

<400>  152

Cys Ala Arg Asp Leu Leu Trp Phe Gly Glu Glu Pro His Trp Tyr Phe 
1               5                   10                  15      


Asp Leu Trp 
            


<210>  153
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  6537 light junction

<400>  153

Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val Phe 
1               5                   10              


<210>  154
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  6532 heavy junction

<400>  154

Cys Thr Thr Gly Ser Tyr Leu Ser Tyr His Ser Gly Ser Gly Tyr Leu 
1               5                   10                  15      


Asp Ile Trp 
            


<210>  155
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  6532 light junction

<400>  155

Cys Gln Ser Tyr Asp Ser Arg Leu Asn Asp Asn Cys Val Phe 
1               5                   10                  


<210>  156
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-4A heavy junction

<400>  156

Cys Thr Thr Asp Gln Arg Phe Glu Gly Pro Val Pro Ala Ser Asn Gln 
1               5                   10                  15      


Trp Leu Val Gly Tyr Tyr His Tyr Tyr Gly Met Asp Val Trp 
            20                  25                  30  


<210>  157
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-4A  light junction

<400>  157

Cys Gln Gln Tyr Asn Ser Asn Pro Ile Thr Phe 
1               5                   10      


<210>  158
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-14 heavy junction

<400>  158

Cys Ile Pro Thr Ala Tyr Tyr Asp Tyr Val Trp Gly Ser Tyr Arg Ser 
1               5                   10                  15      


Asp Tyr Trp 
            


<210>  159
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-14  light junction

<400>  159

Cys Gln Ser Tyr Asp Ser Ser Leu Arg Asp Ala Tyr Val Phe 
1               5                   10                  


<210>  160
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-2B heavy junction

<400>  160

Cys Ala Arg Ala Leu Pro Ser Met Val Arg Gly Val Ile Tyr Tyr Tyr 
1               5                   10                  15      


Tyr Gly Met Asp Val Trp 
            20          


<210>  161
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-2B light junction

<400>  161

Cys Gln Gln Tyr Gly Ser Ser Phe Thr Phe 
1               5                   10  


<210>  162
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C heavy junction

<400>  162

Cys Ala Arg Phe Leu Gly Tyr Ser Tyr Gly Thr Asn Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Gly Met Asp Val Trp 
            20      


<210>  163
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C light junction

<400>  163

Cys Met Gln Ala Leu Gln Thr Leu Thr Phe 
1               5                   10  


<210>  164
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-19 heavy junction

<400>  164

Cys Ala Arg Glu Gly Ser Ser Ser Thr Ile Leu Thr Pro Val Asp Tyr 
1               5                   10                  15      


Tyr Tyr Gly Met Asp Val Trp 
            20              


<210>  165
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-19 light junction

<400>  165

Cys Met Gln Gly Leu Gln Thr Pro Pro Ala Leu 
1               5                   10      


<210>  166
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  6544 heavy junction

<400>  166

Cys Ala Asn Ile Ser Asp Trp Leu Leu Val Trp Arg Tyr Phe Asp Phe 
1               5                   10                  15      


Trp 
    


<210>  167
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  6544 light junction

<400>  167

Cys Gln Gln Tyr Asn Asn Trp Pro Pro Trp Thr Phe 
1               5                   10          


<210>  168
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-4-A8 heavy junction

<400>  168

Cys Ala Lys Asp Arg Glu Gly Arg Ser Asn Val Gly Ala Ile Cys Ser 
1               5                   10                  15      


Phe Trp 
        


<210>  169
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-4-A8 light junction

<400>  169

Cys Gln Gln Tyr Tyr Ser Thr Pro Leu Thr Phe 
1               5                   10      


<210>  170
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-15 heavy junction

<400>  170

Cys Val Lys Pro Gln Gly Tyr Tyr Asp Ser Ser Gly Tyr Ser Arg Ala 
1               5                   10                  15      


Phe Asp Ile Trp 
            20  


<210>  171
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-15 light junction

<400>  171

Cys Gln Ala Trp Asp Ser Ser Thr Ala Val Phe 
1               5                   10      


<210>  172
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-20 heavy junction

<400>  172

Cys Ala Lys Asp Tyr Asp Phe Trp Ser Gly Ser Arg His Phe Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  173
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-20 light junction

<400>  173

Cys Gly Thr Trp Asp Ser Ser Leu Ser Ala Gly Val Phe 
1               5                   10              


<210>  174
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9B heavy junction

<400>  174

Cys Ala Lys Lys Gly Gly Val Trp Gly Ser Tyr Ala Trp Tyr Phe Asp 
1               5                   10                  15      


Leu Trp 
        


<210>  175
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9B light junction

<400>  175

Cys Gln Gln Tyr Gly Gly Ser Pro Thr Phe 
1               5                   10  


<210>  176
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-4-C12 heavy junction

<400>  176

Cys Ala Lys Gly Pro Met Ile Ser Tyr Tyr Ala Trp Phe Asp Pro Trp 
1               5                   10                  15      


<210>  177
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-4-C12 light junction

<400>  177

Cys Gln Gln Tyr Asn Phe Tyr Ala Ser Trp Thr Phe 
1               5                   10          


<210>  178
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-12 heavy junction

<400>  178

Cys Ala Lys Asp Leu Gly Ser Gly Ser Tyr Ala Ala Leu Phe Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  179
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-12 light junction

<400>  179

Cys Gln Gln Tyr Tyr Ser Ser Pro Pro Phe Phe 
1               5                   10      


<210>  180
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-16 heavy junction

<400>  180

Cys Ala Lys Glu Met Ser Thr Tyr Phe Asn Gly Val Asp Val Trp 
1               5                   10                  15  


<210>  181
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-16 light junction

<400>  181

Cys Ala Ala Trp Ser Tyr Ser Leu Asn Gly Arg Val Phe 
1               5                   10              


<210>  182
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-3 heavy junction

<400>  182

Cys Ala Lys Asp Ile Thr Val Ala Arg Leu Tyr Gly Met Asp Val Trp 
1               5                   10                  15      


<210>  183
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-3 light junction

<400>  183

Cys Ala Ala Trp Asp Asp Ser Leu Thr Gly Arg Val Phe 
1               5                   10              


<210>  184
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  6536 heavy junction

<400>  184

Cys Ala Arg Glu His Leu Asp Phe Arg Ser Gly Tyr Ala Ser Trp Leu 
1               5                   10                  15      


Val Gly Asp Phe Val Tyr Trp 
            20              


<210>  185
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  6536 light junction

<400>  185

Cys Asn Ser Arg Asp Ser Ser Gly Asn His Leu Gly Val Phe 
1               5                   10                  


<210>  186
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  6533 heavy junction

<400>  186

Cys Ala Arg Asp Arg Ala Ile Ala Ala Leu Gly Asp Leu Leu Tyr Tyr 
1               5                   10                  15      


Tyr Tyr Gly Met Asp Val Trp 
            20              


<210>  187
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  6533 light junction

<400>  187

Cys Gly Thr Trp Asp Ser Ser Leu Ser Ser Trp Val Phe 
1               5                   10              


<210>  188
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  6545 heavy junction

<400>  188

Cys Ala Arg Asp Trp Pro Leu Trp Asn Asp Phe Trp Ser Gly Tyr Leu 
1               5                   10                  15      


Ala Tyr Trp 
            


<210>  189
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  6545 light junction

<400>  189

Cys Gln Gln Tyr Asn Asn Trp Pro Pro Leu Thr Phe 
1               5                   10          


<210>  190
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-7C heavy junction

<400>  190

Cys Ala Arg Gly Gly Asp Ile Val Val Val Val Thr Ser Thr Asp Tyr 
1               5                   10                  15      


Tyr Gly Met Asp Val Trp 
            20          


<210>  191
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-7C light junction

<400>  191

Cys Leu Gln His Asn Ser Tyr Pro Arg Thr Phe 
1               5                   10      


<210>  192
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-2C heavy junction

<400>  192

Cys Ala Arg Gly Ser Glu Thr Gly Gly Arg Gly Leu Glu Trp Leu Leu 
1               5                   10                  15      


Tyr Thr Ser Pro Tyr Phe Asp Tyr Trp 
            20                  25  


<210>  193
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-2C light junction

<400>  193

Cys Gln Gln Ser Tyr Ser Thr Pro Pro Tyr Thr Phe 
1               5                   10          


<210>  194
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 heavy junction

<400>  194

Cys Ala Thr Lys Met Gly Gly Tyr Gly Asp Tyr Trp His Trp Tyr Phe 
1               5                   10                  15      


Asp Leu Trp 
            


<210>  195
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 light junction

<400>  195

Cys Gln Gln Tyr Asn Asp Trp Pro Leu Thr Phe 
1               5                   10      


<210>  196
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  6538 heavy junction

<400>  196

Cys Ala Ser Met Asn Thr Phe Gly Gly Ile Met Asp Pro Phe Asp Tyr 
1               5                   10                  15      


Trp 
    


<210>  197
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  6538 light junction

<400>  197

Cys Ser Ser Tyr Thr Ser Ser Ser Thr Tyr Val Phe 
1               5                   10          


<210>  198
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-13 heavy junction

<400>  198

Cys Ala Arg Pro Tyr Thr Ser Gly Trp Ser Gly Val Asp Tyr Trp 
1               5                   10                  15  


<210>  199
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-13 light junction

<400>  199

Cys Gln Gln Arg Ser His Trp Pro Pro Glu Leu Thr Phe 
1               5                   10              


<210>  200
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-8B heavy junction

<400>  200

Cys Ala Gly Ser Arg Tyr Tyr Tyr Tyr Gly Met Asp Val Trp 
1               5                   10                  


<210>  201
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-8B light junction

<400>  201

Cys Gln Gln Tyr Gly Ser Ser Pro Leu Thr Phe 
1               5                   10      


<210>  202
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 heavy junction

<400>  202

Cys Thr Thr Arg Ile Val Leu Asn Gly Met Asp Val Trp 
1               5                   10              


<210>  203
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 light junction

<400>  203

Cys Gln Ser Tyr Asp Ser Arg Leu Ser Asp Gly Val Val Phe 
1               5                   10                  


<210>  204
<211>  28
<212>  PRT
<213>  artificial sequence

<220>
<223>  6658 heavy junction

<400>  204

Cys Ala Arg Val Val Gln Ile Asp Ser Ser Ile Ile Leu Val Pro Ala 
1               5                   10                  15      


Ala Ile Asn Asp Tyr Tyr Tyr Gly Met Asp Val Trp 
            20                  25              


<210>  205
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  6658 light junction

<400>  205

Cys Cys Ser Tyr Ala Gly Ser Ser Thr Tyr Val Phe 
1               5                   10          


<210>  206
<211>  475
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C heavy chain

<400>  206

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ser Ile Thr Thr Ser Ser Ser Tyr Ile Tyr Tyr Ala 
65                  70                  75                  80  


Tyr Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Phe Leu Gly Tyr Ser Tyr Gly Thr Asn Tyr Tyr 
        115                 120                 125             


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  207
<211>  237
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C light chain

<400>  207

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu His Ser Asp Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            100                 105                 110         


Met Gln Ala Leu Gln Thr Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  208
<211>  476
<212>  PRT
<213>  artificial sequence

<220>
<223>  040 heavy chain

<400>  208

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Thr Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ile Thr Leu Arg Ala Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Asn Ser Tyr Tyr Tyr His Ser Ser Gly Leu Leu Ile 
        115                 120                 125             


Arg Trp Asp Asp Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  209
<211>  233
<212>  PRT
<213>  artificial sequence

<220>
<223>  040 light chain

<400>  209

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              


Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Ser Ser 
            100                 105                 110         


Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  210
<211>  469
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 heavy chain

<400>  210

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Gly Phe 
        35                  40                  45              


Ser Ser Ala Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Lys Thr Asp 
65                  70                  75                  80  


Tyr Ala Ala Pro Val Lys Gly Arg Phe Ile Met Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Ala 
            100                 105                 110         


Gly Val Tyr Tyr Cys Thr Thr Arg Ile Val Leu Asn Gly Met Asp Val 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  211
<211>  237
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 light chain

<400>  211

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ala Asn Asn Asn Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr 
            100                 105                 110         


Asp Ser Arg Leu Ser Asp Gly Val Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         


<210>  212
<211>  472
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 heavy chain

<400>  212

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Trp Gly Ala Gly Leu Leu Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe 
        35                  40                  45              


Ser Gly Asn Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Thr Lys Met Gly Gly Tyr Gly Asp Tyr Trp His Trp Tyr 
        115                 120                 125             


Phe Asp Leu Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  213
<211>  233
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 light chain

<400>  213

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu 
        35                  40                  45              


Phe Thr Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Arg 
                85                  90                  95      


Leu Gln Ser Glu Asp Phe Ala Phe Tyr Tyr Cys Gln Gln Tyr Asn Asp 
            100                 105                 110         


Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  214
<211>  473
<212>  PRT
<213>  artificial sequence

<220>
<223>  6660 heavy chain

<400>  214

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Ala Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Pro Thr Asp 
65                  70                  75                  80  


Tyr Ala Ala Pro Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Ala Gly Val Val Cys Leu His Gly Ser Ser 
        115                 120                 125             


Cys Val Gly Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  215
<211>  237
<212>  PRT
<213>  artificial sequence

<220>
<223>  6660 light chain

<400>  215

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Tyr Ser Asn Ile 
        35                  40                  45              


Gly Ala Gly Tyr Asp Val Tyr Trp Tyr Gln Gln Val Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr 
            100                 105                 110         


Asp Ser Arg Leu Arg Asp Phe Trp Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         


<210>  216
<211>  481
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C heavy chain

<400>  216

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Ser Gly Asn Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly His Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Val Arg Phe Cys Ser Gly Ala Ser Cys Ala 
        115                 120                 125             


Ser Val Tyr Leu Leu Asp Leu Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
    130                 135                 140                 


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  217
<211>  233
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C light chain

<400>  217

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              


Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Thr Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser 
            100                 105                 110         


Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  218
<211>  470
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-3 heavy chain

<400>  218

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Gly Ile Ile Gly Asn Gly Asp Val Thr Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Asp Ile Thr Val Ala Arg Leu Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  219
<211>  235
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-3 light chain

<400>  219

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr 
            20                  25                  30          


Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Ser Tyr Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Arg Asn Asp Gln Arg Pro Ser Gly Val Pro Glu 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
                85                  90                  95      


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
            100                 105                 110         


Asp Ser Leu Thr Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
145                 150                 155                 160 


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
                165                 170                 175     


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
            180                 185                 190         


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
        195                 200                 205             


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
    210                 215                 220                 


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235 


<210>  220
<211>  129
<212>  PRT
<213>  artificial sequence

<220>
<223>  094 heavy chain variable region

<400>  220

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Arg Glu Met Gln Leu Val Arg Gly Ser Tyr Tyr Tyr 
            100                 105                 110         


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  221
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  094 light chain variable region

<400>  221

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Arg Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Cys Trp Tyr Gln Arg Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Leu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ser Leu 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  222
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  105 heavy chain variable region

<400>  222

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Thr Asn Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Lys Ser Asn Ala Asp Gly Gly Thr Arg Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asn Phe Trp Ser Gly Arg Asp Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Asn Gly Ala Thr Val Thr Val Ser Ser 
        115                 120         


<210>  223
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  105 light chain variable region

<400>  223

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Arg Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Arg Asp His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  224
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  116 heavy chain variable region

<400>  224

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ser Asn Pro Tyr Ser Gly Gly Thr His Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Trp Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Gly Phe Asp Ser Asn Gly Trp Ser Asn Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  225
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  116 light chain variable region

<400>  225

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Arg 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Thr Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Gly Asp Ser Ser Gly Thr Tyr 
                85                  90                  95      


Pro Gly Val Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  226
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  121 heavy chain variable region

<400>  226

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Tyr Cys Ser Gly Gly Thr Cys Tyr Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  227
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  121 light chain variable region

<400>  227

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Phe Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  228
<211>  132
<212>  PRT
<213>  artificial sequence

<220>
<223>  125 heavy chain variable region

<400>  228

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asn Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Arg Phe Cys Ser Gly Ala Ser Cys Ala Ser Val Tyr 
            100                 105                 110         


Leu Leu Asp Leu Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  229
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  125 light chain variable region

<400>  229

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  230
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  132 heavy chain variable region

<400>  230

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp His Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Gln Arg Gly Val Thr Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  231
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  132 light chain variable region

<400>  231

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Arg Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Leu Tyr Gly Asn Asp Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Arg Asp Ser Cys Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


<210>  232
<211>  129
<212>  PRT
<213>  artificial sequence

<220>
<223>  133 heavy chain variable region

<400>  232

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Pro Pro Gly Gln Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Arg Arg Glu Met Gln Leu Val Arg Gly Ser Tyr Tyr Tyr 
            100                 105                 110         


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  233
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  133 light chain variable region

<400>  233

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Ser Cys Ser Gly Asp Arg Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asp Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ser Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ser Leu 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  234
<211>  130
<212>  PRT
<213>  artificial sequence

<220>
<223>  139 heavy chain variable region

<400>  234

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Leu Val Pro Ala Ala Met Pro Trp Ser Val Leu Phe 
            100                 105                 110         


Tyr Tyr Phe Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  235
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  139 light chain variable region

<400>  235

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Ala Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ser Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Phe Asn Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


<210>  236
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  140 heavy chain variable region

<400>  236

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Val Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Phe His Tyr Tyr Asp Ser Ser Gly Ser Glu Thr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  237
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  140 light chain variable region

<400>  237

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly His Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Ser Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Asn Arg Thr Tyr 
                85                  90                  95      


Ser Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  238
<211>  130
<212>  PRT
<213>  artificial sequence

<220>
<223>  141 heavy chain variable region

<400>  238

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Thr Tyr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Gln Glu Val Phe Gly Val Leu Ile Met Ala Tyr Tyr 
            100                 105                 110         


Asp Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  239
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  141 light chain variable region

<400>  239

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Arg Arg Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  240
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  142 heavy chain variable region

<400>  240

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ser Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Met Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Ser Ser Trp Leu Tyr Tyr Met Asp Val Trp Gly Lys Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  241
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  142 light chain variable region

<400>  241

Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Lys 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg 
            100                 105         


<210>  242
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  143 heavy chain variable region

<400>  242

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Lys Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly His Tyr Cys Thr Asp Gly Val Cys Tyr Ser Leu Pro 
            100                 105                 110         


Tyr Phe Met Asp Val Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  243
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  143 light chain variable region

<400>  243

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Ser Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Glu Val Ile Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  244
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  176 heavy chain variable region

<400>  244

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ser Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Met Ala Arg Gly Leu Ile Leu His Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  245
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  176 light chain variable region

<400>  245

Asn Phe Met Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  246
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  18-1-A9 heavy chain variable region

<400>  246

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Thr Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Asn Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Asn Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Arg Val Val Lys Val Val His Ala Ile Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  247
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  18-1-A9 light chain variable region

<400>  247

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ile His 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Asn Ser Pro 
                85                  90                  95      


Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  248
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  18-1-D10 heavy chain variable region

<400>  248

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Ile Arg Ser Thr 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Phe His Asn Gly Ser Thr Asn Tyr Val Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Leu Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ser Ser Asp Pro Asn Tyr Tyr Tyr Ala Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  249
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  18-1-D10 light chain variable region

<400>  249

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Arg 
            100                 105         


<210>  250
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  18-1-D3 heavy chain variable region

<400>  250

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Asp 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Leu Ile Lys Asn Lys Thr Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Val Lys Asn Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Tyr Arg Glu Glu Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  251
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  18-1-D3 light chain variable region

<400>  251

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Lys Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Ile Ile Phe 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Pro Asp Ile Ser Gly Pro Tyr 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  252
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  19-2-12C heavy chain variable region

<400>  252

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Ile Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ser Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ala Asp Cys Val Leu Leu Trp Phe Gly Asp Leu Leu Tyr 
            100                 105                 110         


Cys Gly Met Asp Val Trp Gly Gln Gly Ala Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  253
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  19-2-12C light chain variable region

<400>  253

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Gly Ser Ser Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  254
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  45-4-A5 heavy chain variable region

<400>  254

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Ile Asp Gly Gly Thr Thr Asp Phe Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ile Pro Pro Pro Met Val Arg Gly Val Thr Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  255
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  45-4-A5 light chain variable region

<400>  255

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Thr Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ser Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Arg Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  256
<211>  129
<212>  PRT
<213>  artificial sequence

<220>
<223>  45-4-B10 heavy chain variable region

<400>  256

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Tyr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Leu Ser Asp Gly Phe Leu Ser Leu Ser Asn His Phe 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Arg Asp His Gly His Arg Leu 
        115                 120                 125             


Leu 
    


<210>  257
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  45-4-B10 light chain variable region

<400>  257

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Phe Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr His Cys Gln Gln Tyr Asn Asp Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg 
            100                 105         


<210>  258
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-11D heavy chain variable region

<400>  258

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Met Phe Gly Thr Val Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Thr Gly Val Ala Trp Ala Pro Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  259
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-11D light chain variable region

<400>  259

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Val Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Ala 
                85                  90                  95      


Arg Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  260
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-1C heavy chain variable region

<400>  260

Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Arg Arg Pro Ile Met Val Arg Gly Val Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Pro Gly Asn Pro Gly His Arg Leu Leu 
        115                 120             


<210>  261
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-1C light chain variable region

<400>  261

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Ile Leu Gly 
                85                  90                  95      


Ala Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  262
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-3D heavy chain variable region

<400>  262

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Arg Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Tyr Gly Asp Phe Trp Ser Gly Tyr Cys Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  263
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-3D light chain variable region

<400>  263

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr His Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu 
                85                  90                  95      


Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  264
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-7A heavy chain variable region

<400>  264

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Gln 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Val Arg Trp Met Ala Thr Ile Gly Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  265
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-7A light chain variable region

<400>  265

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Phe Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  266
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-7D heavy chain variable region

<400>  266

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Lys Trp Glu Leu Leu Trp Val Val Gly Thr Asn Phe Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  267
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-7D light chain variable region

<400>  267

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Ala Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Thr Ser 
                85                  90                  95      


Leu Gly Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  268
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-9A heavy chain variable region

<400>  268

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Thr Gly Gly Thr His Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Arg Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Leu Ile Ala Thr Arg His Gly Arg Gly Thr Ser Trp Tyr 
            100                 105                 110         


Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  269
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-9A light chain variable region

<400>  269

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Tyr Ile Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  270
<211>  129
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-9C heavy chain variable region

<400>  270

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Lys Arg Ile Thr Ile Ser Gly Val Leu Ile Pro Leu 
            100                 105                 110         


Tyr Trp Phe Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  271
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-3-9C light chain variable region

<400>  271

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  272
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-4-D4 heavy chain variable region

<400>  272

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Glu 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Leu Thr Pro Asn Arg Leu Arg Trp Thr Gln Thr 
            100                 105                 110         


Glu Tyr Tyr Tyr Tyr Tyr Thr Met Asp Val Trp Gly Gln Arg Asp His 
        115                 120                 125             


Gly His Arg Leu Leu 
    130             


<210>  273
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  56-4-D4 light chain variable region

<400>  273

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Arg Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  274
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-2B heavy chain variable region

<400>  274

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ile Asn Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Pro Ser Met Val Arg Gly Val Ile Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  275
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-2B light chain variable region

<400>  275

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Gly Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  276
<211>  129
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-2C heavy chain variable region

<400>  276

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Leu Tyr Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Ser Glu Thr Gly Gly Arg Gly Leu Glu Trp Leu Leu Tyr Thr 
            100                 105                 110         


Ser Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  277
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-2C light chain variable region

<400>  277

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile His Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  278
<211>  137
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-4A heavy chain variable region

<400>  278

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Lys Trp Val 
        35                  40                  45              


Gly Arg Val Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Gln Arg Phe Glu Gly Pro Val Pro Ala Ser Asn 
            100                 105                 110         


Gln Trp Leu Val Gly Tyr Tyr His Tyr Tyr Gly Met Asp Val Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135         


<210>  279
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-4A light chain variable region

<400>  279

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Ser 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Asn Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  280
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-7B heavy chain variable region

<400>  280

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Ser Arg Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Trp Leu His Ser Arg Ser Pro Arg Ala Gly Asn Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  281
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-7B light chain variable region

<400>  281

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  282
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-7C heavy chain variable region

<400>  282

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Gly Tyr Asp Gly Ser Asn Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ile Val Val Val Val Thr Ser Thr Asp Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  283
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-7C light chain variable region

<400>  283

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Gly Ile Arg Ser Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  284
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-8B heavy chain variable region

<400>  284

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Thr Asp Ser Tyr Thr Asp Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Arg Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  285
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-8B light chain variable region

<400>  285

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  286
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9A heavy chain variable region

<400>  286

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Arg Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Val Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Asp Ser Ser Gly Tyr Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  287
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9A light chain variable region

<400>  287

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Thr Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser Asp Ser Ser Ala Thr Tyr 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  288
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9B heavy chain variable region

<400>  288

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Leu Gly Gly Ser Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Lys Gly Gly Val Trp Gly Ser Tyr Ala Trp Tyr Phe Asp Leu 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  289
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9B light chain variable region

<400>  289

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gly Ser Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  290
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-4-A8 heavy chain variable region

<400>  290

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Gly Gly Gly Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Glu Gly Arg Ser Asn Val Gly Ala Ile Cys Ser Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  291
<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-4-A8 light chain variable region

<400>  291

Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Asn 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Asp Ile 
            100                 105                 110         


Lys 
    


<210>  292
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-4-C12 heavy chain variable region

<400>  292

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Pro Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Met Ile Ser Tyr Tyr Ala Trp Phe Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  293
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-4-C12 light chain variable region

<400>  293

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Phe Tyr Ala Ser 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg 
            100                 105             


<210>  294
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-10 heavy chain variable region

<400>  294

Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Ser 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Asn Pro Ala Ser Gly Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Phe Trp Ser Gly Ile Thr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  295
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-10 light chain variable region

<400>  295

Asp Ile Gln Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Leu Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Arg 
            100                 105     


<210>  296
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-12 heavy chain variable region

<400>  296

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly Gly Thr Tyr Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Gly Ser Gly Ser Tyr Ala Ala Leu Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  297
<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-12 light chain variable region

<400>  297

Ala Ile Arg Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Tyr Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Ser Pro Pro Phe Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  298
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-13 heavy chain variable region

<400>  298

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Val Ser Ser Ser 
            20                  25                  30          


Asn Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Thr Ile Tyr Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Glu Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Pro Tyr Thr Ser Gly Trp Ser Gly Val Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  299
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-13 light chain variable region

<400>  299

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Gly Asn Arg Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser His Trp Pro Pro 
                85                  90                  95      


Glu Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Arg 
            100                 105                 


<210>  300
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-14 heavy chain variable region

<400>  300

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Ile Pro Thr Ala Tyr Tyr Asp Tyr Val Trp Gly Ser Tyr Arg 
            100                 105                 110         


Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  301
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-14 light chain variable region

<400>  301

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Ile Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Arg Asp Ala Tyr Val Phe Gly Thr Gly Thr Arg Val Thr Val Leu 
            100                 105                 110         


<210>  302
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-15 heavy chain variable region

<400>  302

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Asp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Val Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Pro Gln Gly Tyr Tyr Asp Ser Ser Gly Tyr Ser Arg Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  303
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-15 light chain variable region

<400>  303

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Phe Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Leu Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ala Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  304
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-16 heavy chain variable region

<400>  304

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Asp Ser Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Gly Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Met Ser Thr Tyr Phe Asn Gly Val Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  305
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-16 light chain variable region

<400>  305

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser His 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gln Asn Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Ser Tyr Ser Leu 
                85                  90                  95      


Asn Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  306
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-19 heavy chain variable region

<400>  306

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Arg Phe Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Ser Ser Thr Ile Leu Thr Pro Val Asp Tyr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  307
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-19 light chain variable region

<400>  307

Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Leu Gln Thr Pro Pro Ala Leu Gly Pro Gly Thr Lys Val Glu Ile Arg 
            100                 105                 110         


<210>  308
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-20 heavy chain variable region

<400>  308

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Asn Asn Arg Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Tyr Asp Phe Trp Ser Gly Ser Arg His Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  309
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-20 light chain variable region

<400>  309

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  310
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-3 heavy chain variable region

<400>  310

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ile Gly Asn Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Thr Val Ala Arg Leu Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  311
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-6-3 light chain variable region

<400>  311

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Tyr 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asp Gln Arg Pro Ser Gly Val Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Thr Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  312
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6532.hIgG1.385 heavy chain variable region

<400>  312

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Arg Ser Asn Tyr Gly Thr Thr His Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Gly Ser Tyr Leu Ser Tyr His Ser Gly Ser Gly Tyr 
            100                 105                 110         


Leu Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  313
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6532.hIgG1.385 light chain variable region

<400>  313

Asn Phe Met Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Lys Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Met Tyr Gly Asp Asn Asn Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Asn Asp Asn Cys Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  314
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6533.hIgG1.387 heavy chain variable region

<400>  314

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ala Ile Ala Ala Leu Gly Asp Leu Leu Tyr Tyr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  315
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6533.hIgG1.387 light chain variable region

<400>  315

Asn Phe Met Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Ala Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Asn Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  316
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6535.hIgG1.388 heavy chain variable region

<400>  316

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Ser Ser Ser Gly Lys Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Tyr Cys Gly Gly Asp Cys Tyr Phe Leu Leu Ser Ser 
            100                 105                 110         


Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  317
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6535.hIgG1.388 light chain variable region

<400>  317

Asn Phe Met Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Met Ile Thr Cys Gly Gly Asn Asn Ile Arg Thr Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val His 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Ala Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp His Ser Ser Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  318
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6536.hIgG1.002 heavy chain variable region

<400>  318

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Leu Asp Phe Arg Ser Gly Tyr Ala Ser Trp Leu Val 
            100                 105                 110         


Gly Asp Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  319
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6536.hIgG1.002 light chain variable region

<400>  319

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Tyr Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ala Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Leu Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  320
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6537.hIgG1.390 heavy chain variable region

<400>  320

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Asp Ile Ser Asn Ser Gly Gly Thr Ile Ser Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Leu Trp Phe Gly Glu Glu Pro His Trp Tyr Phe Asp 
            100                 105                 110         


Leu Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  321
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6537.hIgG1.390 light chain variable region

<400>  321

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln His Ile Ser Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  322
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6538.hIgG1.391 heavy chain variable region

<400>  322

Gln Leu Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Ala Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Val Ile His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Met Asn Thr Phe Gly Gly Ile Met Asp Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  323
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6538.hIgG1.391 light chain variable region

<400>  323

Asn Phe Met Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Tyr Val Phe Gly Thr Gly Thr Asn Leu Thr Val Leu 
            100                 105                 110 


<210>  324
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6539.hIgG1.992 heavy chain variable region

<400>  324

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Arg Val Leu Leu Tyr Phe Gly Glu Ser Gly Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  325
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6539.hIgG1.992 light chain variable region

<400>  325

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  326
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6544.hIgG1.999 heavy chain variable region

<400>  326

Glu Val Gln His Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Asp Asn Gly Asp Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Ile Ser Asp Trp Leu Leu Val Trp Arg Tyr Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  327
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6544.hIgG1.999 light chain variable region

<400>  327

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Gly Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  328
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6545.hIgG1.000 heavy chain variable region

<400>  328

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Asp Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Trp Pro Leu Trp Asn Asp Phe Trp Ser Gly Tyr Leu Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  329
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6545.hIgG1.000 light chain variable region

<400>  329

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Thr Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  330
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6650.hIgG1.438 heavy chain variable region

<400>  330

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Thr Tyr Asp Gly Ser Asn Lys Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Arg Ser Arg Ser Trp Tyr Thr Trp Ala Ser Gly Tyr Phe 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  331
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6650.hIgG1.438 light chain variable region

<400>  331

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Thr Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  332
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6651.hIgG1.445 heavy chain variable region

<400>  332

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Ser Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Glu Ser Trp Gln Leu Gly Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  333
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6651.hIgG1.445 light chain variable region

<400>  333

Glu Thr Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Asp Ile Pro Ala Arg Ile Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asp Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  334
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6652.hIgG1.446 heavy chain variable region

<400>  334

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Arg Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Glu Thr Ser Asp Ile Val Val Leu Pro Ala Asp Ala 
            100                 105                 110         


Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  335
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6652.hIgG1.446 light chain variable region

<400>  335

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Glu 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  336
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6653.hIgG1.447 heavy chain variable region

<400>  336

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Gly Ala Ile His Ser Ser Asp Trp Tyr Tyr Tyr Leu Ala 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  337
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6653.hIgG1.447 light chain variable region

<400>  337

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  338
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6654.hIgG1.449 heavy chain variable region

<400>  338

Glu Val Gln Leu Val Glu Ser Gly Gly Val Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Asn Trp Asp Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Leu Gly Gly Glu Phe Trp Ser Gly Ser Cys Ser Gly 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  339
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6654.hIgG1.449 light chain variable region

<400>  339

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Thr Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Glu Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Gly Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  340
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6655.hIgG1.429 heavy chain variable region

<400>  340

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Thr Met Ile Val Val Glu Trp Tyr Phe Asp Leu Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  341
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6655.hIgG1.429 light chain variable region

<400>  341

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 


<210>  342
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6656.hIgG1.432 heavy chain variable region

<400>  342

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Asp Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Phe Asp Trp Leu Leu Thr Pro Ile Asp Tyr Tyr Gly 
            100                 105                 110         


Leu Gly Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  343
<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6656.hIgG1.432 light chain variable region

<400>  343

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Gly Phe Thr Phe Gly Pro Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  344

<400>  344
000

<210>  345

<400>  345
000

<210>  346
<211>  133
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6658.hIgG1.427 heavy chain variable region

<400>  346

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Ser Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Gln Ile Asp Ser Ser Ile Ile Leu Val Pro Ala Ala 
            100                 105                 110         


Ile Asn Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  347
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6658.hIgG1.427 light chain variable region

<400>  347

His Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Arg Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Asp Asn Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  348
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6659.hIgG1.444 heavy chain variable region

<400>  348

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ala Lys Thr Asp Gly Gly Ala Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asp Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Val Gly Val His Ile Trp Asn Phe Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  349
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6659.hIgG1.444 light chain variable region

<400>  349

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ala Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Ser Asp Asn Met Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  350
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6660.hIgG1.448 heavy chain variable region

<400>  350

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Pro Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ala Gly Val Val Cys Leu His Gly Ser Ser Cys Val Gly 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  351
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6660.hIgG1.448 light chain variable region

<400>  351

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Tyr Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Tyr Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Arg Asp Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  352
<211>  129
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6661.hIgG1.450 heavy chain variable region

<400>  352

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Arg Ser Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Leu Trp Phe Gly Glu Leu Leu Ser His Tyr Asp Tyr 
            100                 105                 110         


Tyr Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  353
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6661.hIgG1.450 light chain variable region

<400>  353

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Phe Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  354
<211>  128
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6663.hIgG1.431 heavy chain variable region

<400>  354

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ser Leu Trp Leu Gly Asp Leu Leu Gly Gly Asp Phe Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125             


<210>  355
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6663.hIgG1.431 light chain variable region

<400>  355

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Phe Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Pro Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  356
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6664.hIgG1.433 heavy chain variable region

<400>  356

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Gly Leu Ile Lys Thr Asn Thr His Gly Gly Thr Thr Gly Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Gly Val Val Cys Leu Asp Arg Ser Ser Cys Val Gly 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  357
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6664.hIgG1.433 light chain variable region

<400>  357

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ile Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Asp Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  358
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6665.hIgG1.435 heavy chain variable region

<400>  358

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Glu Ser Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      


Tyr Cys Met Thr Arg Arg Ser Gly Trp Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  359
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6665.hIgG1.435 light chain variable region

<400>  359

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Gln Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Ser Asp Asn Cys Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


<210>  360
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6666.hIgG1.437 heavy chain variable region

<400>  360

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Trp Val Tyr Asn Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  361
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6666.hIgG1.437 light chain variable region

<400>  361

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Arg Asp Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  362
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6667.hIgG1.441 heavy chain variable region

<400>  362

Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Thr Phe Ser Asn Gly Leu Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Ala Asp Gly Gly Thr Thr Asp Tyr Ser Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asn Thr Val Arg Ser Gly Ala Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  363
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6667.hIgG1.441 light chain variable region

<400>  363

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Arg Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ser Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Ser Asp Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  364
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6668.hIgG1.439 heavy chain variable region

<400>  364

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Met 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Gly Asn Tyr Glu Phe Trp Ser Gly Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120             


<210>  365
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6668.hIgG1.439 light chain variable region

<400>  365

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Gly Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp His Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  366
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6669.hIgG1.430 heavy chain variable region

<400>  366

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Ser Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Phe Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Glu Val Val Gly Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  367
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6669.hIgG1.430 light chain variable region

<400>  367

Gln Ala Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Arg Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala His Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Arg Asp Phe Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  368
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6670.hIgG1.434 heavy chain variable region

<400>  368

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Ala Asp Cys Ala Ala 
    50                  55                  60                  


Pro Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Arg Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Arg Val Ser Ala Pro Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  369
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6670.hIgG1.434 light chain variable region

<400>  369

Asn Phe Met Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Gly Ser Tyr Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Gln Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Thr Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asn Ile Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg 
                85                  90                  95      


Leu Arg Asp His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  370
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6672.hIgG1.442 heavy chain variable region

<400>  370

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Arg Ser Ser Tyr Thr Asn Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asn Val Lys Phe Gly Glu Leu Leu Pro Pro Tyr Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  371
<211>  110
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6672.hIgG1.442 light chain variable region

<400>  371

Gln Ala Val Val Thr Arg Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Asp Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Asp Lys Ala Pro Lys Leu 
        35                  40                  45              


Val Ile Ser Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Asn Ser Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  372
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6673.hIgG1.443 heavy chain variable region

<400>  372

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Thr Arg Tyr Ser Ser Ala Trp Phe Asn Asp Tyr Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  373
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  BSN.6673.hIgG1.443 light chain variable region

<400>  373

Asn Phe Met Leu Thr Gln Ser Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val Gln Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Arg Asp Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  374
<211>  129
<212>  PRT
<213>  artificial sequence

<220>
<223>  P6 heavy chain variable region

<400>  374

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Tyr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Leu Ser Asp Gly Phe Leu Ser Leu Ser Asn His Phe 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  375
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  P6 light chain variable region

<400>  375

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Cys Gly Ser Ser Pro 
                85                  90                  95      


Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  376
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  P7 heavy chain variable region

<400>  376

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Ser Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Thr Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Asp Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Gly Gly Arg Asp Met Ala Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  377
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  P7 light chain variable region

<400>  377

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Asp Thr Ala Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ala Arg 
                85                  90                  95      


Leu Arg Asp Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  378
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C variant LCDR1

<400>  378

Arg Ser Ser Gln Ser Leu Leu His Ser Glu Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  379
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C variant LCDR1

<400>  379

Arg Ser Ser Gln Ser Leu Leu His Ser Asp Ser Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  380
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-3-9C variant LCDR1

<400>  380

Arg Ser Ser Gln Ser Leu Leu His Ser Asp Ala Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  381
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 variant HCDR2

<400>  381

Arg Ile Lys Ser Lys Thr Glu Gly Gly Lys Thr Asp Tyr Ala Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210>  382
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 variant HCDR2

<400>  382

Arg Ile Lys Ser Lys Thr Asp Ser Gly Lys Thr Asp Tyr Ala Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210>  383
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 variant HCDR2

<400>  383

Arg Ile Lys Ser Lys Thr Asp Ala Gly Lys Thr Asp Tyr Ala Ala Pro 
1               5                   10                  15      


Val Lys Gly 
            


<210>  384
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 variant HCDR3

<400>  384

Arg Ile Val Leu Asn Ser Met Asp Val 
1               5                   


<210>  385
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 variant HCDR3

<400>  385

Arg Ile Val Leu Asn Ala Met Asp Val 
1               5                   


<210>  386
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 variant LCDR3

<400>  386

Gln Ser Tyr Asp Ser Arg Leu Ser Glu Gly Val Val 
1               5                   10          


<210>  387
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 variant LCDR3

<400>  387

Gln Ser Tyr Asp Ser Arg Leu Ser Asp Ser Val Val 
1               5                   10          


<210>  388
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  6662 variant LCDR3

<400>  388

Gln Ser Tyr Asp Ser Arg Leu Ser Asp Ala Val Val 
1               5                   10          


<210>  389
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 variant HCDR2

<400>  389

Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  390
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 variant HCDR2

<400>  390

Glu Ile Asn His Ala Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  391
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 variant HCDR2

<400>  391

Glu Ile Asn His Gly Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  392
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  6541 variant HCDR2

<400>  392

Glu Ile Thr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  393
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-4C-12 HCDR1

<400>  393

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  394
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-4C-12 HCDR2

<400>  394

Gly Ile Ser Gly Pro Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  395
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-4C-12 HCDR3

<400>  395

Gly Pro Met Ile Ser Tyr Tyr Ala Trp Phe Asp Pro 
1               5                   10          


<210>  396
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant sequence of 66-4C-12 HCDR3

<400>  396

Gly Pro Met Ile Ser Tyr Tyr Ala Trp Phe Glu Pro 
1               5                   10          


<210>  397
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-4C-12 LCDR1

<400>  397

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  398
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-4C-12 LCDR2

<400>  398

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  399
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  66-4C-12 LCDR3

<400>  399

Gln Gln Tyr Asn Phe Tyr Ala Ser Trp Thr 
1               5                   10  


<210>  400
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  6651 HCDR1

<400>  400

Gly Gly Ser Ile Ser Thr Ser Ser Tyr Tyr Trp Gly 
1               5                   10          


<210>  401
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  6651 HCDR2

<400>  401

Asn Ile Phe Tyr Ser Gly Ser Thr Tyr Ser Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  402
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  6651 HCDR3

<400>  402

Val Glu Ser Trp Gln Leu Gly Ala Phe Asp Ile 
1               5                   10      


<210>  403
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  6651 LCDR1

<400>  403

Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  404
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  6651 LCDR2

<400>  404

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  405
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  6651 LCDR3

<400>  405

Gln Gln Tyr Asn Asp Trp Pro Arg Thr 
1               5                   


