                         SEQUENCE LISTING

<110>  BicycleTx Limited
 
<120>  BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR INTEGRIN alphaVbeta3

<130>  BIC-C-P2513PCT

<150>  GB1900527.1
<151>  2019-01-15

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  1

Cys Lys His Tyr Gly Arg Thr Asp Cys His Asp Thr Cys 
1               5                   10              


<210>  2
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  2

Cys Asp Ala Ser Arg Leu Asp Cys Val Pro Ser Ser Ser Gly Cys 
1               5                   10                  15  


<210>  3
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  3

Cys Pro His Ile Gly Arg Thr Asp Cys Pro Pro Cys 
1               5                   10          


<210>  4
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  4

Cys Tyr Asp Asp Cys Arg Arg Leu Asp His Trp Gln His Ser Cys 
1               5                   10                  15  


<210>  5
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  5

Cys Arg His Ser Asp Arg Leu Asp Cys Leu Pro Cys 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  6

Cys Pro His Ser Leu Arg Leu Asp Cys His Asp Cys 
1               5                   10          


<210>  7
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  7

Cys Glu Leu Arg His Asp Leu Cys Arg Ser His Asp His Trp Cys 
1               5                   10                  15  


<210>  8
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  8

Cys Arg His Thr His Arg Leu Asp Cys Thr Glu Ser Cys 
1               5                   10              


<210>  9
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  9

Cys Pro His Ala Gly Arg Cys Asp Gly Pro Pro Thr Cys 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  10

Cys Gly His Val Gly Arg Leu Asp Cys His Ile Pro Cys 
1               5                   10              


<210>  11
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  11

Cys Pro His Val His Arg Leu Asp Cys His Ala Pro Cys 
1               5                   10              


<210>  12
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  12

Cys Asp His Arg Arg Met Asp Cys Pro Glu Val Cys 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  13

Cys Asp His Arg Arg Met Asp Cys Pro Thr Leu Cys 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  14

Cys Asp His Arg Arg Met Asp Cys Pro Thr Asn Cys 
1               5                   10          


<210>  15
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  15

Cys Asp His Thr Arg Met Asp Cys Pro His Asn Cys 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  16

Cys His Val Gly Arg Met Asp Cys Phe Gln Glu Cys 
1               5                   10          


<210>  17
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  17

Cys Lys His Ser Gly Arg Thr Asp Cys His Asp Thr Cys 
1               5                   10              


<210>  18
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  18

Cys Asp Ala Ser Arg Leu Asp Cys Pro Tyr Ser Val Ser Leu Cys 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  19

Cys Asp Ala Ser Arg Leu Asp Cys Pro Val Val Ser His Leu Cys 
1               5                   10                  15  


<210>  20
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  20

Cys Lys His Ala Gly Arg Thr Asp Cys Pro Pro Cys 
1               5                   10          


<210>  21
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  21

Cys Arg His Ala Gly Arg Thr Asp Cys Pro Pro Cys 
1               5                   10          


<210>  22
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  22

Cys Pro His Leu Gly Arg Cys Asp Gly Pro Leu Val Cys 
1               5                   10              


<210>  23
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa represents any amino acid

<220>
<221>  Xaa
<222>  (4)..(5)
<223>  Xaa represents any amino acid

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa is T or L

<220>
<221>  Xaa
<222>  (10)..(11)
<223>  Xaa represents any amino acid

<220>
<221>  Xaa
<222>  (12)..(12)
<223>  Xaa represents any amino acid or is absent

<400>  23

Cys Xaa His Xaa Xaa Arg Xaa Asp Cys Xaa Xaa Xaa Cys 
1               5                   10              


<210>  24
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is D or E

<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is A or L

<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is S or R

<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is R or H

<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is L or D

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa is D or L

<220>
<221>  Xaa
<222>  (9)..(12)
<223>  Xaa represents any amino acid

<220>
<221>  Xaa
<222>  (13)..(13)
<223>  Xaa is S or H

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa represents any amino acid

<400>  24

Cys Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Cys 
1               5                   10                  15  


<210>  25
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa is A or L

<220>
<221>  Xaa
<222>  (11)..(11)
<223>  Xaa is P or L

<220>
<221>  Xaa
<222>  (12)..(12)
<223>  Xaa is T or V

<400>  25

Cys Pro His Xaa Gly Arg Cys Asp Gly Pro Xaa Xaa Cys 
1               5                   10              


<210>  26
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is D or H

<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is H or V

<220>
<221>  Xaa
<222>  (4)..(4)
<223>  Xaa represents any amino acid

<220>
<221>  Xaa
<222>  (9)..(9)
<223>  Xaa is P or F

<220>
<221>  Xaa
<222>  (10)..(11)
<223>  Xaa represents any amino acid

<400>  26

Cys Xaa Xaa Xaa Arg Met Asp Cys Xaa Xaa Xaa Cys 
1               5                   10          


<210>  27
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  27

Cys Asp His Arg Arg Met Asp Cys Pro Thr Ala Cys 
1               5                   10          


<210>  28
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  28

Cys His Ala Thr Arg Asn Met Asp Cys Tyr Thr Cys 
1               5                   10          


<210>  29
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  29

Cys Pro His Leu Glu Arg Leu Asp Cys His Asp Ser Cys 
1               5                   10              


<210>  30
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  30

Cys His Lys Gly Arg Gly Asp His Cys Leu Thr Cys 
1               5                   10          


<210>  31
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  31

Cys Ser Pro Leu Arg Met Asp Cys His Thr Val Ser Asp Thr Cys 
1               5                   10                  15  


<210>  32
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  32

Cys His Ser Phe Arg Thr Asp Cys His Asn His Cys 
1               5                   10          


<210>  33
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  33

Cys Pro Glu Ser His Tyr Leu Cys Arg Leu Asp His His His Cys 
1               5                   10                  15  


<210>  34
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  34

Cys His Ala Tyr Arg Thr Asp Cys His Asp Tyr Cys 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  35

Cys Asn Pro Arg Ser Asp Ala Pro Cys Glu Pro Cys 
1               5                   10          


<210>  36
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  36

Cys Arg Thr Asp Asp Tyr Arg Asp Cys Asp Ile Cys 
1               5                   10          


<210>  37
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  37

Cys Pro His Ile Ala Arg Thr Asp Cys Pro Pro Cys 
1               5                   10          


<210>  38
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is Agb

<400>  38

Cys Pro His Ile Gly Xaa Thr Asp Cys Pro Pro Cys 
1               5                   10          


<210>  39
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is HArg

<400>  39

Cys Asp Ala Ser Xaa Leu Asp Cys Val Pro Ser Ser Ser Ala Cys 
1               5                   10                  15  


<210>  40
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is HArg

<400>  40

Cys Pro Xaa Ile Ala Arg Thr Asp Cys Pro Pro Cys 
1               5                   10          


<210>  41
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is HArg

<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is HArg

<400>  41

Cys Pro Xaa Ile Gly Xaa Thr Asp Cys Pro Pro Cys 
1               5                   10          


<210>  42
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is HArg

<400>  42

Cys Pro His Ile Gly Xaa Thr Asp Cys Pro Pro Cys 
1               5                   10          


<210>  43
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is HArg

<400>  43

Cys Pro Xaa Ile Gly Arg Thr Asp Cys Pro Pro Cys 
1               5                   10          


<210>  44
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  44

Cys Gly His Val Ala Arg Leu Asp Cys His Ile Pro Cys 
1               5                   10              


<210>  45
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is HArg

<400>  45

Cys Gly His Val Gly Xaa Leu Asp Cys His Ile Pro Cys 
1               5                   10              


<210>  46
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  46

Cys Ala His Val Gly Arg Leu Asp Cys His Ile Pro Cys 
1               5                   10              


<210>  47
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is HArg

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  47

Cys Gly Xaa Val Ala Arg Leu Asp Cys Xaa Ile Pro Cys 
1               5                   10              


<210>  48
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  48

Cys Gly His Val Gly Arg Leu Asp Cys Xaa Ile Pro Cys 
1               5                   10              


<210>  49
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  49

Cys Ala His Val Ala Arg Leu Asp Cys Xaa Ile Pro Cys 
1               5                   10              


<210>  50
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  50

Cys Gly His Val Ala Arg Leu Asp Cys Xaa Ile Pro Cys 
1               5                   10              


<210>  51
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is HArg

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is HArg

<400>  51

Cys Gly His Val Gly Xaa Leu Asp Cys Xaa Ile Pro Cys 
1               5                   10              


<210>  52
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (6)..(6)
<223>  Xaa is HArg

<400>  52

Cys Ala His Val Gly Xaa Leu Asp Cys His Ile Pro Cys 
1               5                   10              


<210>  53
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide


<220>
<221>  Xaa
<222>  (5)..(5)
<223>  Xaa is HArg

<400>  53

Cys Asp Ala Ser Xaa Leu Asp Cys Val Pro Ser Ser Ser Gly Cys 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  54

Cys His Thr Arg Ala His Asp Cys Tyr Trp Glu Ser Ile Val Cys 
1               5                   10                  15  


<210>  55
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  55

Gly Arg Gly Asp Ser Pro 
1               5       


<210>  56
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  56

Ala Cys Leu Asp His Met Glu Cys Arg Gly Asp Met Asp Cys Ala 
1               5                   10                  15  


<210>  57
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  57

Ala Cys Ile Leu Arg Pro Asn Cys Asp Leu Asp Gly Arg Cys Ala 
1               5                   10                  15  


<210>  58
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Peptide

<400>  58

Gly Arg Gly Ser Ser Pro 
1               5       


