                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
 
<120>  AAV-MEDIATED GENE THERAPY RESTORING THE OTOFERLIN GENE

<130>  B377344 D39106

<150>  EP19305071.3
<151>  2019-01-18

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  1997
<212>  PRT
<213>  homo sapiens

<400>  1

Met Ala Leu Leu Ile His Leu Lys Thr Val Ser Glu Leu Arg Gly Arg 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Asp Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Met Leu Glu Ile 
    50                  55                  60                  


Gln Val Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Arg Met Val Leu Gln Lys Val Val Glu Glu Ser His Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Ile Asp Asp Asn Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Cys Val Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Ser Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Glu Lys 
    130                 135                 140                 


Asp Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Ser 
145                 150                 155                 160 


Arg Pro Pro Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser Val Phe 
                165                 170                 175     


Ser Ala Met Lys Leu Gly Lys Asn Arg Ser His Lys Glu Glu Pro Gln 
            180                 185                 190         


Arg Pro Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu 
        195                 200                 205             


Ala Ile Arg Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala 
    210                 215                 220                 


Ser Val Thr Ala Leu Thr Thr Asn Val Ser Asn Lys Arg Ser Lys Pro 
225                 230                 235                 240 


Asp Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val 
                245                 250                 255     


Ser Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp 
            260                 265                 270         


Pro Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met 
        275                 280                 285             


Lys Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp 
    290                 295                 300                 


Phe His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser 
305                 310                 315                 320 


Val Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser 
                325                 330                 335     


Phe Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe 
            340                 345                 350         


His His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ser Gly 
        355                 360                 365             


Leu Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp 
    370                 375                 380                 


Asn Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile 
385                 390                 395                 400 


Glu Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp 
                405                 410                 415     


Ala Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met 
            420                 425                 430         


Asn Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn 
        435                 440                 445             


Lys Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys 
    450                 455                 460                 


Gly Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu 
465                 470                 475                 480 


Gln Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys 
                485                 490                 495     


Val Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr 
            500                 505                 510         


His Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe 
        515                 520                 525             


Leu Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg 
    530                 535                 540                 


Asn Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly 
545                 550                 555                 560 


Glu Gly Val Ser Phe Arg Ala Arg Leu Leu Leu Gly Leu Ala Val Glu 
                565                 570                 575     


Ile Val Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln 
            580                 585                 590         


Val Glu Gln Ala Thr Pro Ile Ser Glu Ser Cys Ala Gly Lys Met Glu 
        595                 600                 605             


Glu Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg 
    610                 615                 620                 


Arg Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr 
625                 630                 635                 640 


Gly Asn Glu Val Asp Gly Leu Ser Arg Pro Gln Arg Pro Arg Pro Arg 
                645                 650                 655     


Lys Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ala Ser 
            660                 665                 670         


Asp Asp Glu Ala Gly Asp Ala Gly Asp Leu Ala Ser Val Ser Ser Thr 
        675                 680                 685             


Pro Pro Met Arg Pro Gln Val Thr Asp Arg Asn Tyr Phe His Leu Pro 
    690                 695                 700                 


Tyr Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp 
705                 710                 715                 720 


Gln Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp 
                725                 730                 735     


Lys Leu Glu Glu Gly Leu Asn Asp Ile Gln Glu Met Ile Lys Thr Glu 
            740                 745                 750         


Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser 
        755                 760                 765             


Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp Lys Asp Gln Gly His 
    770                 775                 780                 


Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg 
785                 790                 795                 800 


Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met Leu Arg Ala Gln Val 
                805                 810                 815     


Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu Cys Gln Asn Phe Leu 
            820                 825                 830         


Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp 
        835                 840                 845             


Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg Val Ala Tyr Ala Arg 
    850                 855                 860                 


Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Thr Gly 
865                 870                 875                 880 


Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys 
                885                 890                 895     


Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Val Glu Leu 
            900                 905                 910         


Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Glu Phe Leu Cys Gly 
        915                 920                 925             


Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala Gln Gly Leu Gly Leu 
    930                 935                 940                 


His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe 
945                 950                 955                 960 


Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp 
                965                 970                 975     


Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln 
            980                 985                 990         


Ser Gln Cys Thr Glu Val Leu Asn  Glu Thr Leu Cys Pro  Thr Trp Asp 
        995                 1000                 1005             


Gln Met  Leu Val Phe Asp Asn  Leu Glu Leu Tyr Gly  Glu Ala His 
    1010                 1015                 1020             


Glu Leu  Arg Asp Asp Pro Pro  Ile Ile Val Ile Glu  Ile Tyr Asp 
    1025                 1030                 1035             


Gln Asp  Ser Met Gly Lys Ala  Asp Phe Met Gly Arg  Thr Phe Ala 
    1040                 1045                 1050             


Lys Pro  Leu Val Lys Met Ala  Asp Glu Ala Tyr Cys  Pro Pro Arg 
    1055                 1060                 1065             


Phe Pro  Pro Gln Leu Glu Tyr  Tyr Gln Ile Tyr Arg  Gly Asn Ala 
    1070                 1075                 1080             


Thr Ala  Gly Asp Leu Leu Ala  Ala Phe Glu Leu Leu  Gln Ile Gly 
    1085                 1090                 1095             


Pro Ala  Gly Lys Ala Asp Leu  Pro Pro Ile Asn Gly  Pro Val Asp 
    1100                 1105                 1110             


Val Asp  Arg Gly Pro Ile Met  Pro Val Pro Met Gly  Ile Arg Pro 
    1115                 1120                 1125             


Val Leu  Ser Lys Tyr Arg Val  Glu Val Leu Phe Trp  Gly Leu Arg 
    1130                 1135                 1140             


Asp Leu  Lys Arg Val Asn Leu  Ala Gln Val Asp Arg  Pro Arg Val 
    1145                 1150                 1155             


Asp Ile  Glu Cys Ala Gly Lys  Gly Val Gln Ser Ser  Leu Ile His 
    1160                 1165                 1170             


Asn Tyr  Lys Lys Asn Pro Asn  Phe Asn Thr Leu Val  Lys Trp Phe 
    1175                 1180                 1185             


Glu Val  Asp Leu Pro Glu Asn  Glu Leu Leu His Pro  Pro Leu Asn 
    1190                 1195                 1200             


Ile Arg  Val Val Asp Cys Arg  Ala Phe Gly Arg Tyr  Thr Leu Val 
    1205                 1210                 1215             


Gly Ser  His Ala Val Ser Ser  Leu Arg Arg Phe Ile  Tyr Arg Pro 
    1220                 1225                 1230             


Pro Asp  Arg Ser Ala Pro Ser  Trp Asn Thr Thr Val  Arg Leu Leu 
    1235                 1240                 1245             


Arg Arg  Cys Arg Val Leu Cys  Asn Gly Gly Ser Ser  Ser His Ser 
    1250                 1255                 1260             


Thr Gly  Glu Val Val Val Thr  Met Glu Pro Glu Val  Pro Ile Lys 
    1265                 1270                 1275             


Lys Leu  Glu Thr Met Val Lys  Leu Asp Ala Thr Ser  Glu Ala Val 
    1280                 1285                 1290             


Val Lys  Val Asp Val Ala Glu  Glu Glu Lys Glu Lys  Lys Lys Lys 
    1295                 1300                 1305             


Lys Lys  Gly Thr Ala Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu 
    1310                 1315                 1320             


Ser Met  Leu Asp Trp Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr 
    1325                 1330                 1335             


Met Lys  Glu Gln Leu Arg Gln  Gln Glu Pro Ser Gly  Ile Asp Leu 
    1340                 1345                 1350             


Glu Glu  Lys Glu Glu Val Asp  Asn Thr Glu Gly Leu  Lys Gly Ser 
    1355                 1360                 1365             


Met Lys  Gly Lys Glu Lys Ala  Arg Ala Ala Lys Glu  Glu Lys Lys 
    1370                 1375                 1380             


Lys Lys  Thr Gln Ser Ser Gly  Ser Gly Gln Gly Ser  Glu Ala Pro 
    1385                 1390                 1395             


Glu Lys  Lys Lys Pro Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys 
    1400                 1405                 1410             


Glu Leu  Glu Ser Glu Phe Asp  Asn Phe Glu Asp Trp  Leu His Thr 
    1415                 1420                 1425             


Phe Asn  Leu Leu Arg Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser 
    1430                 1435                 1440             


Thr Glu  Glu Glu Arg Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys 
    1445                 1450                 1455             


Val Tyr  Lys Val Pro Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly 
    1460                 1465                 1470             


Tyr Asp  Ser Thr Tyr Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp 
    1475                 1480                 1485             


Pro Ile  Asn Val Leu Val Arg  Val Tyr Val Val Arg  Ala Thr Asp 
    1490                 1495                 1500             


Leu His  Pro Ala Asp Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala 
    1505                 1510                 1515             


Ile Arg  Leu Gly Lys Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile 
    1520                 1525                 1530             


Ser Lys  Gln Leu Asn Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu 
    1535                 1540                 1545             


Ala Ser  Phe Pro Met Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp 
    1550                 1555                 1560             


Trp Asp  Leu Val Gly Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile 
    1565                 1570                 1575             


Asp Leu  Glu Asn Arg Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly 
    1580                 1585                 1590             


Ile Ala  Gln Thr Tyr Ser Thr  His Gly Tyr Asn Ile  Trp Arg Asp 
    1595                 1600                 1605             


Pro Met  Lys Pro Ser Gln Ile  Leu Thr Arg Leu Cys  Lys Asp Gly 
    1610                 1615                 1620             


Lys Val  Asp Gly Pro His Phe  Gly Pro Pro Gly Arg  Val Lys Val 
    1625                 1630                 1635             


Ala Asn  Arg Val Phe Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn 
    1640                 1645                 1650             


Gly Gln  Arg Lys Pro Thr Asp  Glu His Val Ala Leu  Leu Ala Leu 
    1655                 1660                 1665             


Arg His  Trp Glu Asp Ile Pro  Arg Ala Gly Cys Arg  Leu Val Pro 
    1670                 1675                 1680             


Glu His  Val Glu Thr Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly 
    1685                 1690                 1695             


Ile Glu  Gln Gly Arg Leu Glu  Leu Trp Val Asp Met  Phe Pro Met 
    1700                 1705                 1710             


Asp Met  Pro Ala Pro Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys 
    1715                 1720                 1725             


Pro Lys  Lys Tyr Glu Leu Arg  Val Ile Ile Trp Asn  Thr Asp Glu 
    1730                 1735                 1740             


Val Val  Leu Glu Asp Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser 
    1745                 1750                 1755             


Asp Ile  Phe Val Arg Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys 
    1760                 1765                 1770             


Gln Asp  Thr Asp Val His Tyr  His Ser Leu Thr Gly  Glu Gly Asn 
    1775                 1780                 1785             


Phe Asn  Trp Arg Tyr Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu 
    1790                 1795                 1800             


Glu Lys  Ile Val Ile Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp 
    1805                 1810                 1815             


Glu Thr  Glu Tyr Lys Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp 
    1820                 1825                 1830             


Asp Ala  Asp His Phe Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu 
    1835                 1840                 1845             


Leu Asp  Leu Asn Arg Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln 
    1850                 1855                 1860             


Cys Thr  Met Glu Met Ala Thr  Gly Glu Val Asp Val  Pro Leu Val 
    1865                 1870                 1875             


Ser Ile  Phe Lys Gln Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu 
    1880                 1885                 1890             


Ala Arg  Asn Glu Asn Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu 
    1895                 1900                 1905             


Ala Glu  Leu His Leu Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro 
    1910                 1915                 1920             


Val Gly  Leu Ala Arg Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn 
    1925                 1930                 1935             


Arg Pro  Asp Thr Ser Phe Ile  Trp Phe Leu Asn Pro  Leu Lys Ser 
    1940                 1945                 1950             


Ala Arg  Tyr Phe Leu Trp His  Thr Tyr Arg Trp Leu  Leu Leu Lys 
    1955                 1960                 1965             


Leu Leu  Leu Leu Leu Leu Leu  Leu Leu Leu Leu Ala  Leu Phe Leu 
    1970                 1975                 1980             


Tyr Ser  Val Pro Gly Tyr Leu  Val Lys Lys Ile Leu  Gly Ala 
    1985                 1990                 1995         


<210>  2
<211>  7171
<212>  DNA
<213>  homo sapiens

<400>  2
atcggagggg ggtcgggagg aggaggagga ggcagcggca gagaagagag aggcgtgtga       60

gccgtgctcc accggctagc tccttcccgc tgctcctgcc tggcagtgcc aggcagccca      120

caccagcatg gccttgctca tccacctcaa gacagtctcg gagctgcggg gcaggggcga      180

ccggatcgcc aaagtgactt tccgagggca atccttctac tctcgggtcc tggagaactg      240

tgaggatgtg gctgactttg atgagacatt tcggtggccg gtggccagca gcatcgacag      300

aaatgagatg ctggagattc aggttttcaa ctacagcaaa gtcttcagca acaagctcat      360

cgggaccttc cgcatggtgc tgcagaaggt ggtagaggag agccatgtgg aggtgactga      420

cacgctgatt gatgacaaca atgctatcat caagaccagc ctgtgcgtgg aggtccggta      480

tcaggccact gacggcacag tgggctcctg ggacgatggg gacttcctgg gagatgagtc      540

tcttcaagag gaagagaagg acagccaaga gacggatgga ctgctcccag gctcccggcc      600

cagctcccgg cccccaggag agaagagctt ccggagagcc gggaggagcg tgttctccgc      660

catgaagctc ggcaaaaacc ggtctcacaa ggaggagccc caaagaccag atgaaccggc      720

ggtgctggag atggaagacc ttgaccatct ggccattcgg ctaggagatg gactggatcc      780

cgactcggtg tctctagcct cagtcacagc tctcaccact aatgtctcca acaagcgatc      840

taagccagac attaagatgg agccaagtgc tgggcggccc atggattacc aggtcagcat      900

cacggtgatc gaggcccggc agctggtggg cttgaacatg gaccctgtgg tgtgcgtgga      960

ggtgggtgac gacaagaagt acacatccat gaaggagtcc actaactgcc cctattacaa     1020

cgagtacttc gtcttcgact tccatgtctc tccggatgtc atgtttgaca agatcatcaa     1080

gatttcggtg attcactcca agaacctgct gcgcagtggc accctggtgg gctccttcaa     1140

aatggacgtg ggaaccgtgt actcgcagcc agagcaccag ttccatcaca agtgggccat     1200

cctgtctgac cccgatgaca tctcctcggg gctgaagggc tacgtgaagt gtgacgttgc     1260

cgtggtgggc aaaggggaca acatcaagac gccccacaag gccaatgaga ccgacgaaga     1320

tgacattgag gggaacttgc tgctccccga gggggtgccc cccgaacgcc agtgggcccg     1380

gttctatgtg aaaatttacc gagcagaggg gctgccccgt atgaacacaa gcctcatggc     1440

caatgtaaag aaggctttca tcggtgaaaa caaggacctc gtggacccct acgtgcaagt     1500

cttctttgct ggccagaagg gcaagacttc agtgcagaag agcagctatg agcccctgtg     1560

gaatgagcag gtcgtcttta cagacctctt ccccccactc tgcaaacgca tgaaggtgca     1620

gatccgagac tcggacaagg tcaacgacgt ggccatcggc acccacttca ttgacctgcg     1680

caagatttct aatgacggag acaaaggctt cctgcccaca ctgggcccag cctgggtgaa     1740

catgtacggc tccacacgta actacacgct gctggatgag catcaggacc tgaacgaggg     1800

cctgggggag ggtgtgtcct tccgggcccg gctcctgctg ggcctggctg tggagatcgt     1860

agacacctcc aaccctgagc tcaccagctc cacagaggtg caggtggagc aggccacgcc     1920

catctcggag agctgtgcag gtaaaatgga agaattcttt ctctttggag ccttcctgga     1980

ggcctcaatg atcgaccgga gaaacggaga caagcccatc acctttgagg tcaccatagg     2040

caactatggg aacgaagttg atggcctgtc ccggccccag cggcctcggc cccggaagga     2100

gccgggggat gaggaagaag tagacctgat tcagaacgca agtgatgacg aggccggtga     2160

tgccggggac ctggcctcag tctcctccac tccaccaatg cggccccagg tcaccgacag     2220

gaactacttc catctgccct acctggagcg aaagccctgc atctacatca agagctggtg     2280

gccggaccag cgccgccgcc tctacaatgc caacatcatg gaccacattg ccgacaagct     2340

ggaagaaggc ctgaacgaca tacaggagat gatcaaaacg gagaagtcct accctgagcg     2400

tcgcctgcgg ggcgtcctgg aggagctgag ctgtggctgc tgccgcttcc tctccctcgc     2460

tgacaaggac cagggccact catcccgcac caggcttgac cgggagcgcc tcaagtcctg     2520

catgagggag ctggaaaaca tggggcagca ggccaggatg ctgcgggccc aggtgaagcg     2580

gcacacggtg cgggacaagc tgaggctgtg ccagaacttc ctgcagaagc tgcgcttcct     2640

ggcggacgag ccccagcaca gcattcccga catcttcatc tggatgatga gcaacaacaa     2700

gcgtgtcgcc tatgcccgtg tgccctccaa ggacctgctc ttctccatcg tggaggagga     2760

gactggcaag gactgcgcca aggtcaagac gctcttcctt aagctgccag ggaagcgggg     2820

cttcggctcg gcaggctgga cagtgcaggc caaggtggag ctgtacctgt ggctgggcct     2880

cagcaaacag cgcaaggagt tcctgtgcgg cctgccctgt ggcttccagg aggtcaaggc     2940

agcccagggc ctgggcctgc atgccttccc acccgtcagc ctggtctaca ccaagaagca     3000

ggcgttccag ctccgagcgc acatgtacca ggcccgcagc ctctttgccg ccgacagcag     3060

cggactctca gacccctttg cccgcgtctt cttcatcaat cagagtcagt gcacagaggt     3120

gctgaatgag accctgtgtc ccacctggga ccagatgctg gtgttcgaca acctggagct     3180

ctatggtgaa gctcatgagc tgagggacga tccgcccatc attgtcattg aaatctatga     3240

ccaggattcc atgggcaaag ctgacttcat gggccggacc ttcgccaaac ccctggtgaa     3300

gatggcagac gaggcgtact gcccaccccg cttcccacct cagctcgagt actaccagat     3360

ctaccgtggc aacgccacag ctggagacct gctggcggcc ttcgagctgc tgcagattgg     3420

accagcaggg aaggctgacc tgccccccat caatggcccg gtggacgtgg accgaggtcc     3480

catcatgccc gtgcccatgg gcatccggcc cgtgctcagc aagtaccgag tggaggtgct     3540

gttctggggc ctacgggacc taaagcgggt gaacctggcc caggtggacc ggccacgggt     3600

ggacatcgag tgtgcaggga agggggtgca gtcgtccctg atccacaatt ataagaagaa     3660

ccccaacttc aacaccctcg tcaagtggtt tgaagtggac ctcccagaga acgagctgct     3720

gcacccgccc ttgaacatcc gtgtggtgga ctgccgggcc ttcggtcgct acacactggt     3780

gggctcccat gccgtcagct ccctgcgacg cttcatctac cggcccccag accgctcggc     3840

ccccagctgg aacaccacgg tcaggcttct ccggcgctgc cgtgtgctgt gcaatggggg     3900

ctcctcctct cactccacag gggaggttgt ggtgactatg gagccagagg tacccatcaa     3960

gaaactggag accatggtga agctggacgc gacttctgaa gctgttgtca aggtggatgt     4020

ggctgaggag gagaaggaga agaagaagaa gaagaagggc actgcggagg agccagagga     4080

ggaggagcca gacgagagca tgctggactg gtggtccaag tactttgcct ccattgacac     4140

catgaaggag caacttcgac aacaagagcc ctctggaatt gacttggagg agaaggagga     4200

agtggacaat accgagggcc tgaaggggtc aatgaagggc aaggagaagg caagggctgc     4260

caaagaggag aagaagaaga aaactcagag ctctggctct ggccaggggt ccgaggcccc     4320

cgagaagaag aaacccaaga ttgatgagct taaggtatac cccaaagagc tggagtccga     4380

gtttgataac tttgaggact ggctgcacac tttcaacttg cttcggggca agaccgggga     4440

tgatgaggat ggctccaccg aggaggagcg cattgtggga cgcttcaagg gctccctctg     4500

cgtgtacaaa gtgccactcc cagaggacgt gtcccgggaa gccggctacg actccaccta     4560

cggcatgttc cagggcatcc cgagcaatga ccccatcaat gtgctggtcc gagtctatgt     4620

ggtccgggcc acggacctgc accctgctga catcaacggc aaagctgacc cctacatcgc     4680

catccggcta ggcaagactg acatccgcga caaggagaac tacatctcca agcagctcaa     4740

ccctgtcttt gggaagtcct ttgacatcga ggcctccttc cccatggaat ccatgctgac     4800

ggtggctgtg tatgactggg acctggtggg cactgatgac ctcattgggg aaaccaagat     4860

cgacctggag aaccgcttct acagcaagca ccgcgccacc tgcggcatcg cccagaccta     4920

ctccacacat ggctacaata tctggcggga ccccatgaag cccagccaga tcctgacccg     4980

cctctgcaaa gacggcaaag tggacggccc ccactttggg ccccctggga gagtgaaggt     5040

ggccaaccgc gtcttcactg ggccctctga gattgaggac gagaacggtc agaggaagcc     5100

cacagacgag catgtggcgc tgttggccct gaggcactgg gaggacatcc cccgcgcagg     5160

ctgccgcctg gtgccagagc atgtggagac gaggccgctg ctcaaccccg acaagccggg     5220

catcgagcag ggccgcctgg agctgtgggt ggacatgttc cccatggaca tgccagcccc     5280

tgggacgcct ctggacatct cacctcggaa gcccaagaag tacgagctgc gggtcatcat     5340

ctggaacaca gatgaggtgg tcttggagga cgacgacttc ttcacagggg agaagtccag     5400

tgacatcttc gtgagggggt ggctgaaggg ccagcaggag gacaagcagg acacagacgt     5460

ccactaccac tccctcactg gcgagggcaa cttcaactgg cgctacctgt tccccttcga     5520

ctacctggcg gcggaggaga agatcgtcat ctccaagaag gagtccatgt tctcctggga     5580

cgagaccgag tacaagatcc ccgcgcggct caccctgcag atctgggatg cggaccactt     5640

ctccgctgac gacttcctgg gggccatcga gctggacctg aaccggttcc cgcggggcgc     5700

aaagacagcc aagcagtgca ccatggagat ggccaccggg gaggtggacg tgcccctcgt     5760

gtccatcttc aagcaaaagc gcgtcaaagg ctggtggccc ctcctggccc gcaatgagaa     5820

cgatgagttt gagctcacgg gcaaggtgga ggctgagctg catttactga cagcagagga     5880

ggcagagaag aacccagtgg gcctggcccg caatgaacct gaccccctag agaaacccaa     5940

ccggcccgac acgagcttca tctggttcct gaaccctctc aagtcggctc gctacttctt     6000

gtggcacacg tatcgctggc tgctcctcaa actgttgctg ctcctgctgc tgctcctcct     6060

cctcgccctg ttcctctact ctgtgcctgg ctacctggtc aagaaaatcc tcggggcctg     6120

agcccagtgg cctcctggcc ggcccgacac ggccttcgtc tggttcctca accctctcaa     6180

gtccatcaag tacctcatct gcacccggta caagtggctc atcatcaaga tcgtgctggc     6240

gctgttgggg ctgctcatgt tggggctctt cctctacagc ctccctggct acatggtcaa     6300

aaagctcctt ggggcatgaa ggccgccagc tcccgccagc cgctccccag ccctgccgca     6360

tttcctttca gtggcttgga ctctttccca tctcccctgg ggagcctgag gagcccagcg     6420

tccactcttc atgccttggg ccgagcctgc ctcctgcttg cgggggccgc ctgtcctcac     6480

tgccccaggc tgcggcttgc ccagtcccgc ccctctgacc cctgcctgtg ggctggggag     6540

ccttggatgg ggtggggacc tggaatgggt ctctcttgcc ccacctggct gaggcgccac     6600

ccttcttcag gcccaggctc cagaggaaga ctcctgaaac cctccccagg tcttccaagt     6660

acaggattga agctttagtg aaattaacca aggaccatgg gtcagtgccc agggctttaa     6720

aaagaatgaa cgagcaaaag gtatccccgc cgtgacccct gcagatagca ccggtctttg     6780

atccgcagca ggggccagac cctgcccaca agtcccagcg cggctgcttc tgccactgct     6840

gggctccact tggctcctct cacttcccag ggggtcgcct gtcctgcctg tgggtttcca     6900

tggcttccca gagctccctc tgccccagcc agcgcctcca ggcccagctg aggagctgtg     6960

agaagcagca gaggggactc cccatcccgg gcacaccctg tcctcccacc cctgccccct     7020

tgcccttcca gccctttcag ctgcagctgg gagctggccc gtcaagtgct gcccctgcct     7080

gtgtctgggt ttctgttggc tgtttttctt ttcttgagtg gtgatttttc tctaaataaa     7140

agaagtcaag cactgaaaaa aaaaaaaaaa a                                    7171


<210>  3
<211>  2676
<212>  DNA
<213>  homo sapiens

<400>  3
atggccttgc tcatccacct caagacagtc tcggagctgc ggggcagggg cgaccggatc       60

gccaaagtga ctttccgagg gcaatccttc tactctcggg tcctggagaa ctgtgaggat      120

gtggctgact ttgatgagac atttcggtgg ccggtggcca gcagcatcga cagaaatgag      180

atgctggaga ttcaggtttt caactacagc aaagtcttca gcaacaagct catcgggacc      240

ttccgcatgg tgctgcagaa ggtggtagag gagagccatg tggaggtgac tgacacgctg      300

attgatgaca acaatgctat catcaagacc agcctgtgcg tggaggtccg gtatcaggcc      360

actgacggca cagtgggctc ctgggacgat ggggacttcc tgggagatga gtctcttcaa      420

gaggaagaga aggacagcca agagacggat ggactgctcc caggctcccg gcccagctcc      480

cggcccccag gagagaagag cttccggaga gccgggagga gcgtgttctc cgccatgaag      540

ctcggcaaaa accggtctca caaggaggag ccccaaagac cagatgaacc ggcggtgctg      600

gagatggaag accttgacca tctggccatt cggctaggag atggactgga tcccgactcg      660

gtgtctctag cctcagtcac agctctcacc actaatgtct ccaacaagcg atctaagcca      720

gacattaaga tggagccaag tgctgggcgg cccatggatt accaggtcag catcacggtg      780

atcgaggccc ggcagctggt gggcttgaac atggaccctg tggtgtgcgt ggaggtgggt      840

gacgacaaga agtacacatc catgaaggag tccactaact gcccctatta caacgagtac      900

ttcgtcttcg acttccatgt ctctccggat gtcatgtttg acaagatcat caagatttcg      960

gtgattcact ccaagaacct gctgcgcagt ggcaccctgg tgggctcctt caaaatggac     1020

gtgggaaccg tgtactcgca gccagagcac cagttccatc acaagtgggc catcctgtct     1080

gaccccgatg acatctcctc ggggctgaag ggctacgtga agtgtgacgt tgccgtggtg     1140

ggcaaagggg acaacatcaa gacgccccac aaggccaatg agaccgacga agatgacatt     1200

gaggggaact tgctgctccc cgagggggtg ccccccgaac gccagtgggc ccggttctat     1260

gtgaaaattt accgagcaga ggggctgccc cgtatgaaca caagcctcat ggccaatgta     1320

aagaaggctt tcatcggtga aaacaaggac ctcgtggacc cctacgtgca agtcttcttt     1380

gctggccaga agggcaagac ttcagtgcag aagagcagct atgagcccct gtggaatgag     1440

caggtcgtct ttacagacct cttcccccca ctctgcaaac gcatgaaggt gcagatccga     1500

gactcggaca aggtcaacga cgtggccatc ggcacccact tcattgacct gcgcaagatt     1560

tctaatgacg gagacaaagg cttcctgccc acactgggcc cagcctgggt gaacatgtac     1620

ggctccacac gtaactacac gctgctggat gagcatcagg acctgaacga gggcctgggg     1680

gagggtgtgt ccttccgggc ccggctcctg ctgggcctgg ctgtggagat cgtagacacc     1740

tccaaccctg agctcaccag ctccacagag gtgcaggtgg agcaggccac gcccatctcg     1800

gagagctgtg caggtaaaat ggaagaattc tttctctttg gagccttcct ggaggcctca     1860

atgatcgacc ggagaaacgg agacaagccc atcacctttg aggtcaccat aggcaactat     1920

gggaacgaag ttgatggcct gtcccggccc cagcggcctc ggccccggaa ggagccgggg     1980

gatgaggaag aagtagacct gattcagaac gcaagtgatg acgaggccgg tgatgccggg     2040

gacctggcct cagtctcctc cactccacca atgcggcccc aggtcaccga caggaactac     2100

ttccatctgc cctacctgga gcgaaagccc tgcatctaca tcaagagctg gtggccggac     2160

cagcgccgcc gcctctacaa tgccaacatc atggaccaca ttgccgacaa gctggaagaa     2220

ggcctgaacg acatacagga gatgatcaaa acggagaagt cctaccctga gcgtcgcctg     2280

cggggcgtcc tggaggagct gagctgtggc tgctgccgct tcctctccct cgctgacaag     2340

gaccagggcc actcatcccg caccaggctt gaccgggagc gcctcaagtc ctgcatgagg     2400

gagctggaaa acatggggca gcaggccagg atgctgcggg cccaggtgaa gcggcacacg     2460

gtgcgggaca agctgaggct gtgccagaac ttcctgcaga agctgcgctt cctggcggac     2520

gagccccagc acagcattcc cgacatcttc atctggatga tgagcaacaa caagcgtgtc     2580

gcctatgccc gtgtgccctc caaggacctg ctcttctcca tcgtggagga ggagactggc     2640

aaggactgcg ccaaggtcaa gacgctcttc cttaag                               2676


<210>  4
<211>  3318
<212>  DNA
<213>  homo sapiens

<400>  4
ctgccaggga agcggggctt cggctcggca ggctggacag tgcaggccaa ggtggagctg       60

tacctgtggc tgggcctcag caaacagcgc aaggagttcc tgtgcggcct gccctgtggc      120

ttccaggagg tcaaggcagc ccagggcctg ggcctgcatg ccttcccacc cgtcagcctg      180

gtctacacca agaagcaggc gttccagctc cgagcgcaca tgtaccaggc ccgcagcctc      240

tttgccgccg acagcagcgg actctcagac ccctttgccc gcgtcttctt catcaatcag      300

agtcagtgca cagaggtgct gaatgagacc ctgtgtccca cctgggacca gatgctggtg      360

ttcgacaacc tggagctcta tggtgaagct catgagctga gggacgatcc gcccatcatt      420

gtcattgaaa tctatgacca ggattccatg ggcaaagctg acttcatggg ccggaccttc      480

gccaaacccc tggtgaagat ggcagacgag gcgtactgcc caccccgctt cccacctcag      540

ctcgagtact accagatcta ccgtggcaac gccacagctg gagacctgct ggcggccttc      600

gagctgctgc agattggacc agcagggaag gctgacctgc cccccatcaa tggcccggtg      660

gacgtggacc gaggtcccat catgcccgtg cccatgggca tccggcccgt gctcagcaag      720

taccgagtgg aggtgctgtt ctggggccta cgggacctaa agcgggtgaa cctggcccag      780

gtggaccggc cacgggtgga catcgagtgt gcagggaagg gggtgcagtc gtccctgatc      840

cacaattata agaagaaccc caacttcaac accctcgtca agtggtttga agtggacctc      900

ccagagaacg agctgctgca cccgcccttg aacatccgtg tggtggactg ccgggccttc      960

ggtcgctaca cactggtggg ctcccatgcc gtcagctccc tgcgacgctt catctaccgg     1020

cccccagacc gctcggcccc cagctggaac accacggtca ggcttctccg gcgctgccgt     1080

gtgctgtgca atgggggctc ctcctctcac tccacagggg aggttgtggt gactatggag     1140

ccagaggtac ccatcaagaa actggagacc atggtgaagc tggacgcgac ttctgaagct     1200

gttgtcaagg tggatgtggc tgaggaggag aaggagaaga agaagaagaa gaagggcact     1260

gcggaggagc cagaggagga ggagccagac gagagcatgc tggactggtg gtccaagtac     1320

tttgcctcca ttgacaccat gaaggagcaa cttcgacaac aagagccctc tggaattgac     1380

ttggaggaga aggaggaagt ggacaatacc gagggcctga aggggtcaat gaagggcaag     1440

gagaaggcaa gggctgccaa agaggagaag aagaagaaaa ctcagagctc tggctctggc     1500

caggggtccg aggcccccga gaagaagaaa cccaagattg atgagcttaa ggtatacccc     1560

aaagagctgg agtccgagtt tgataacttt gaggactggc tgcacacttt caacttgctt     1620

cggggcaaga ccggggatga tgaggatggc tccaccgagg aggagcgcat tgtgggacgc     1680

ttcaagggct ccctctgcgt gtacaaagtg ccactcccag aggacgtgtc ccgggaagcc     1740

ggctacgact ccacctacgg catgttccag ggcatcccga gcaatgaccc catcaatgtg     1800

ctggtccgag tctatgtggt ccgggccacg gacctgcacc ctgctgacat caacggcaaa     1860

gctgacccct acatcgccat ccggctaggc aagactgaca tccgcgacaa ggagaactac     1920

atctccaagc agctcaaccc tgtctttggg aagtcctttg acatcgaggc ctccttcccc     1980

atggaatcca tgctgacggt ggctgtgtat gactgggacc tggtgggcac tgatgacctc     2040

attggggaaa ccaagatcga cctggagaac cgcttctaca gcaagcaccg cgccacctgc     2100

ggcatcgccc agacctactc cacacatggc tacaatatct ggcgggaccc catgaagccc     2160

agccagatcc tgacccgcct ctgcaaagac ggcaaagtgg acggccccca ctttgggccc     2220

cctgggagag tgaaggtggc caaccgcgtc ttcactgggc cctctgagat tgaggacgag     2280

aacggtcaga ggaagcccac agacgagcat gtggcgctgt tggccctgag gcactgggag     2340

gacatccccc gcgcaggctg ccgcctggtg ccagagcatg tggagacgag gccgctgctc     2400

aaccccgaca agccgggcat cgagcagggc cgcctggagc tgtgggtgga catgttcccc     2460

atggacatgc cagcccctgg gacgcctctg gacatctcac ctcggaagcc caagaagtac     2520

gagctgcggg tcatcatctg gaacacagat gaggtggtct tggaggacga cgacttcttc     2580

acaggggaga agtccagtga catcttcgtg agggggtggc tgaagggcca gcaggaggac     2640

aagcaggaca cagacgtcca ctaccactcc ctcactggcg agggcaactt caactggcgc     2700

tacctgttcc ccttcgacta cctggcggcg gaggagaaga tcgtcatctc caagaaggag     2760

tccatgttct cctgggacga gaccgagtac aagatccccg cgcggctcac cctgcagatc     2820

tgggatgcgg accacttctc cgctgacgac ttcctggggg ccatcgagct ggacctgaac     2880

cggttcccgc ggggcgcaaa gacagccaag cagtgcacca tggagatggc caccggggag     2940

gtggacgtgc ccctcgtgtc catcttcaag caaaagcgcg tcaaaggctg gtggcccctc     3000

ctggcccgca atgagaacga tgagtttgag ctcacgggca aggtggaggc tgagctgcat     3060

ttactgacag cagaggaggc agagaagaac ccagtgggcc tggcccgcaa tgaacctgac     3120

cccctagaga aacccaaccg gcccgacacg agcttcatct ggttcctgaa ccctctcaag     3180

tcggctcgct acttcttgtg gcacacgtat cgctggctgc tcctcaaact gttgctgctc     3240

ctgctgctgc tcctcctcct cgccctgttc ctctactctg tgcctggcta cctggtcaag     3300

aaaatcctcg gggcctga                                                   3318


<210>  5
<211>  1997
<212>  PRT
<213>  homo sapiens

<400>  5

Met Ala Leu Leu Ile His Leu Lys Thr Val Ser Glu Leu Arg Gly Arg 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Asp Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Met Leu Glu Ile 
    50                  55                  60                  


Gln Val Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Arg Met Val Leu Gln Lys Val Val Glu Glu Ser His Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Ile Asp Asp Asn Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Cys Val Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Ser Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Glu Lys 
    130                 135                 140                 


Asp Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Ser 
145                 150                 155                 160 


Arg Pro Pro Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser Val Phe 
                165                 170                 175     


Ser Ala Met Lys Leu Gly Lys Asn Arg Ser His Lys Glu Glu Pro Gln 
            180                 185                 190         


Arg Pro Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu 
        195                 200                 205             


Ala Ile Arg Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala 
    210                 215                 220                 


Ser Val Thr Ala Leu Thr Thr Asn Val Ser Asn Lys Arg Ser Lys Pro 
225                 230                 235                 240 


Asp Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val 
                245                 250                 255     


Ser Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp 
            260                 265                 270         


Pro Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met 
        275                 280                 285             


Lys Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp 
    290                 295                 300                 


Phe His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser 
305                 310                 315                 320 


Val Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser 
                325                 330                 335     


Phe Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe 
            340                 345                 350         


His His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ser Gly 
        355                 360                 365             


Leu Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp 
    370                 375                 380                 


Asn Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile 
385                 390                 395                 400 


Glu Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp 
                405                 410                 415     


Ala Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met 
            420                 425                 430         


Asn Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn 
        435                 440                 445             


Lys Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys 
    450                 455                 460                 


Gly Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu 
465                 470                 475                 480 


Gln Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys 
                485                 490                 495     


Val Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr 
            500                 505                 510         


His Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe 
        515                 520                 525             


Leu Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg 
    530                 535                 540                 


Asn Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly 
545                 550                 555                 560 


Glu Gly Val Ser Phe Arg Ala Arg Leu Leu Leu Gly Leu Ala Val Glu 
                565                 570                 575     


Ile Val Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln 
            580                 585                 590         


Val Glu Gln Ala Thr Pro Ile Ser Glu Ser Cys Ala Gly Lys Met Glu 
        595                 600                 605             


Glu Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg 
    610                 615                 620                 


Arg Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr 
625                 630                 635                 640 


Gly Asn Glu Val Asp Gly Leu Ser Arg Pro Gln Arg Pro Arg Pro Arg 
                645                 650                 655     


Lys Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ala Ser 
            660                 665                 670         


Asp Asp Glu Ala Gly Asp Ala Gly Asp Leu Ala Ser Val Ser Ser Thr 
        675                 680                 685             


Pro Pro Met Arg Pro Gln Val Thr Asp Arg Asn Tyr Phe His Leu Pro 
    690                 695                 700                 


Tyr Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp 
705                 710                 715                 720 


Gln Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp 
                725                 730                 735     


Lys Leu Glu Glu Gly Leu Asn Asp Ile Gln Glu Met Ile Lys Thr Glu 
            740                 745                 750         


Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser 
        755                 760                 765             


Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp Lys Asp Gln Gly His 
    770                 775                 780                 


Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg 
785                 790                 795                 800 


Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met Leu Arg Ala Gln Val 
                805                 810                 815     


Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu Cys Gln Asn Phe Leu 
            820                 825                 830         


Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp 
        835                 840                 845             


Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg Val Ala Tyr Ala Arg 
    850                 855                 860                 


Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Thr Gly 
865                 870                 875                 880 


Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys 
                885                 890                 895     


Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Val Glu Leu 
            900                 905                 910         


Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Glu Phe Leu Cys Gly 
        915                 920                 925             


Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala Gln Gly Leu Gly Leu 
    930                 935                 940                 


His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe 
945                 950                 955                 960 


Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp 
                965                 970                 975     


Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln 
            980                 985                 990         


Ser Gln Cys Thr Glu Val Leu Asn  Glu Thr Leu Cys Pro  Thr Trp Asp 
        995                 1000                 1005             


Gln Met  Leu Val Phe Asp Asn  Leu Glu Leu Tyr Gly  Glu Ala His 
    1010                 1015                 1020             


Glu Leu  Arg Asp Asp Pro Pro  Ile Ile Val Ile Glu  Ile Tyr Asp 
    1025                 1030                 1035             


Gln Asp  Ser Met Gly Lys Ala  Asp Phe Met Gly Arg  Thr Phe Ala 
    1040                 1045                 1050             


Lys Pro  Leu Val Lys Met Ala  Asp Glu Ala Tyr Cys  Pro Pro Arg 
    1055                 1060                 1065             


Phe Pro  Pro Gln Leu Glu Tyr  Tyr Gln Ile Tyr Arg  Gly Asn Ala 
    1070                 1075                 1080             


Thr Ala  Gly Asp Leu Leu Ala  Ala Phe Glu Leu Leu  Gln Ile Gly 
    1085                 1090                 1095             


Pro Ala  Gly Lys Ala Asp Leu  Pro Pro Ile Asn Gly  Pro Val Asp 
    1100                 1105                 1110             


Val Asp  Arg Gly Pro Ile Met  Pro Val Pro Met Gly  Ile Arg Pro 
    1115                 1120                 1125             


Val Leu  Ser Lys Tyr Arg Val  Glu Val Leu Phe Trp  Gly Leu Arg 
    1130                 1135                 1140             


Asp Leu  Lys Arg Val Asn Leu  Ala Gln Val Asp Arg  Pro Arg Val 
    1145                 1150                 1155             


Asp Ile  Glu Cys Ala Gly Lys  Gly Val Gln Ser Ser  Leu Ile His 
    1160                 1165                 1170             


Asn Tyr  Lys Lys Asn Pro Asn  Phe Asn Thr Leu Val  Lys Trp Phe 
    1175                 1180                 1185             


Glu Val  Asp Leu Pro Glu Asn  Glu Leu Leu His Pro  Pro Leu Asn 
    1190                 1195                 1200             


Ile Arg  Val Val Asp Cys Arg  Ala Phe Gly Arg Tyr  Thr Leu Val 
    1205                 1210                 1215             


Gly Ser  His Ala Val Ser Ser  Leu Arg Arg Phe Ile  Tyr Arg Pro 
    1220                 1225                 1230             


Pro Asp  Arg Ser Ala Pro Ser  Trp Asn Thr Thr Val  Arg Leu Leu 
    1235                 1240                 1245             


Arg Arg  Cys Arg Val Leu Cys  Asn Gly Gly Ser Ser  Ser His Ser 
    1250                 1255                 1260             


Thr Gly  Glu Val Val Val Thr  Met Glu Pro Glu Val  Pro Ile Lys 
    1265                 1270                 1275             


Lys Leu  Glu Thr Met Val Lys  Leu Asp Ala Thr Ser  Glu Ala Val 
    1280                 1285                 1290             


Val Lys  Val Asp Val Ala Glu  Glu Glu Lys Glu Lys  Lys Lys Lys 
    1295                 1300                 1305             


Lys Lys  Gly Thr Ala Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu 
    1310                 1315                 1320             


Ser Met  Leu Asp Trp Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr 
    1325                 1330                 1335             


Met Lys  Glu Gln Leu Arg Gln  Gln Glu Pro Ser Gly  Ile Asp Leu 
    1340                 1345                 1350             


Glu Glu  Lys Glu Glu Val Asp  Asn Thr Glu Gly Leu  Lys Gly Ser 
    1355                 1360                 1365             


Met Lys  Gly Lys Glu Lys Ala  Arg Ala Ala Lys Glu  Glu Lys Lys 
    1370                 1375                 1380             


Lys Lys  Thr Gln Ser Ser Gly  Ser Gly Gln Gly Ser  Glu Ala Pro 
    1385                 1390                 1395             


Glu Lys  Lys Lys Pro Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys 
    1400                 1405                 1410             


Glu Leu  Glu Ser Glu Phe Asp  Asn Phe Glu Asp Trp  Leu His Thr 
    1415                 1420                 1425             


Phe Asn  Leu Leu Arg Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser 
    1430                 1435                 1440             


Thr Glu  Glu Glu Arg Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys 
    1445                 1450                 1455             


Val Tyr  Lys Val Pro Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly 
    1460                 1465                 1470             


Tyr Asp  Ser Thr Tyr Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp 
    1475                 1480                 1485             


Pro Ile  Asn Val Leu Val Arg  Val Tyr Val Val Arg  Ala Thr Asp 
    1490                 1495                 1500             


Leu His  Pro Ala Asp Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala 
    1505                 1510                 1515             


Ile Arg  Leu Gly Lys Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile 
    1520                 1525                 1530             


Ser Lys  Gln Leu Asn Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu 
    1535                 1540                 1545             


Ala Ser  Phe Pro Met Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp 
    1550                 1555                 1560             


Trp Asp  Leu Val Gly Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile 
    1565                 1570                 1575             


Asp Leu  Glu Asn Arg Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly 
    1580                 1585                 1590             


Ile Ala  Gln Thr Tyr Ser Thr  His Gly Tyr Asn Ile  Trp Arg Asp 
    1595                 1600                 1605             


Pro Met  Lys Pro Ser Gln Ile  Leu Thr Arg Leu Cys  Lys Asp Gly 
    1610                 1615                 1620             


Lys Val  Asp Gly Pro His Phe  Gly Pro Pro Gly Arg  Val Lys Val 
    1625                 1630                 1635             


Ala Asn  Arg Val Phe Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn 
    1640                 1645                 1650             


Gly Gln  Arg Lys Pro Thr Asp  Glu His Val Ala Leu  Leu Ala Leu 
    1655                 1660                 1665             


Arg His  Trp Glu Asp Ile Pro  Arg Ala Gly Cys Arg  Leu Val Pro 
    1670                 1675                 1680             


Glu His  Val Glu Thr Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly 
    1685                 1690                 1695             


Ile Glu  Gln Gly Arg Leu Glu  Leu Trp Val Asp Met  Phe Pro Met 
    1700                 1705                 1710             


Asp Met  Pro Ala Pro Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys 
    1715                 1720                 1725             


Pro Lys  Lys Tyr Glu Leu Arg  Val Ile Ile Trp Asn  Thr Asp Glu 
    1730                 1735                 1740             


Val Val  Leu Glu Asp Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser 
    1745                 1750                 1755             


Asp Ile  Phe Val Arg Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys 
    1760                 1765                 1770             


Gln Asp  Thr Asp Val His Tyr  His Ser Leu Thr Gly  Glu Gly Asn 
    1775                 1780                 1785             


Phe Asn  Trp Arg Tyr Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu 
    1790                 1795                 1800             


Glu Lys  Ile Val Ile Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp 
    1805                 1810                 1815             


Glu Thr  Glu Tyr Lys Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp 
    1820                 1825                 1830             


Asp Ala  Asp His Phe Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu 
    1835                 1840                 1845             


Leu Asp  Leu Asn Arg Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln 
    1850                 1855                 1860             


Cys Thr  Met Glu Met Ala Thr  Gly Glu Val Asp Val  Pro Leu Val 
    1865                 1870                 1875             


Ser Ile  Phe Lys Gln Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu 
    1880                 1885                 1890             


Ala Arg  Asn Glu Asn Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu 
    1895                 1900                 1905             


Ala Glu  Leu His Leu Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro 
    1910                 1915                 1920             


Val Gly  Leu Ala Arg Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn 
    1925                 1930                 1935             


Arg Pro  Asp Thr Ala Phe Val  Trp Phe Leu Asn Pro  Leu Lys Ser 
    1940                 1945                 1950             


Ile Lys  Tyr Leu Ile Cys Thr  Arg Tyr Lys Trp Leu  Ile Ile Lys 
    1955                 1960                 1965             


Ile Val  Leu Ala Leu Leu Gly  Leu Leu Met Leu Gly  Leu Phe Leu 
    1970                 1975                 1980             


Tyr Ser  Leu Pro Gly Tyr Met  Val Lys Lys Leu Leu  Gly Ala 
    1985                 1990                 1995         


<210>  6
<211>  1230
<212>  PRT
<213>  homo sapiens

<400>  6

Met Ile Lys Thr Glu Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val 
1               5                   10                  15      


Leu Glu Glu Leu Ser Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp 
            20                  25                  30          


Lys Asp Gln Gly His Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu 
        35                  40                  45              


Lys Ser Cys Met Arg Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met 
    50                  55                  60                  


Leu Arg Ala Gln Val Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu 
65                  70                  75                  80  


Cys Gln Asn Phe Leu Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln 
                85                  90                  95      


His Ser Ile Pro Asp Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg 
            100                 105                 110         


Val Ala Tyr Ala Arg Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val 
        115                 120                 125             


Glu Glu Glu Thr Gly Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu 
    130                 135                 140                 


Lys Leu Pro Gly Lys Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln 
145                 150                 155                 160 


Ala Lys Val Glu Leu Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys 
                165                 170                 175     


Glu Phe Leu Cys Gly Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala 
            180                 185                 190         


Gln Gly Leu Gly Leu His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr 
        195                 200                 205             


Lys Lys Gln Ala Phe Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser 
    210                 215                 220                 


Leu Phe Ala Ala Asp Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val 
225                 230                 235                 240 


Phe Phe Ile Asn Gln Ser Gln Cys Thr Glu Val Leu Asn Glu Thr Leu 
                245                 250                 255     


Cys Pro Thr Trp Asp Gln Met Leu Val Phe Asp Asn Leu Glu Leu Tyr 
            260                 265                 270         


Gly Glu Ala His Glu Leu Arg Asp Asp Pro Pro Ile Ile Val Ile Glu 
        275                 280                 285             


Ile Tyr Asp Gln Asp Ser Met Gly Lys Ala Asp Phe Met Gly Arg Thr 
    290                 295                 300                 


Phe Ala Lys Pro Leu Val Lys Met Ala Asp Glu Ala Tyr Cys Pro Pro 
305                 310                 315                 320 


Arg Phe Pro Pro Gln Leu Glu Tyr Tyr Gln Ile Tyr Arg Gly Asn Ala 
                325                 330                 335     


Thr Ala Gly Asp Leu Leu Ala Ala Phe Glu Leu Leu Gln Ile Gly Pro 
            340                 345                 350         


Ala Gly Lys Ala Asp Leu Pro Pro Ile Asn Gly Pro Val Asp Val Asp 
        355                 360                 365             


Arg Gly Pro Ile Met Pro Val Pro Met Gly Ile Arg Pro Val Leu Ser 
    370                 375                 380                 


Lys Tyr Arg Val Glu Val Leu Phe Trp Gly Leu Arg Asp Leu Lys Arg 
385                 390                 395                 400 


Val Asn Leu Ala Gln Val Asp Arg Pro Arg Val Asp Ile Glu Cys Ala 
                405                 410                 415     


Gly Lys Gly Val Gln Ser Ser Leu Ile His Asn Tyr Lys Lys Asn Pro 
            420                 425                 430         


Asn Phe Asn Thr Leu Val Lys Trp Phe Glu Val Asp Leu Pro Glu Asn 
        435                 440                 445             


Glu Leu Leu His Pro Pro Leu Asn Ile Arg Val Val Asp Cys Arg Ala 
    450                 455                 460                 


Phe Gly Arg Tyr Thr Leu Val Gly Ser His Ala Val Ser Ser Leu Arg 
465                 470                 475                 480 


Arg Phe Ile Tyr Arg Pro Pro Asp Arg Ser Ala Pro Ser Trp Asn Thr 
                485                 490                 495     


Thr Gly Glu Val Val Val Thr Met Glu Pro Glu Val Pro Ile Lys Lys 
            500                 505                 510         


Leu Glu Thr Met Val Lys Leu Asp Ala Thr Ser Glu Ala Val Val Lys 
        515                 520                 525             


Val Asp Val Ala Glu Glu Glu Lys Glu Lys Lys Lys Lys Lys Lys Gly 
    530                 535                 540                 


Thr Ala Glu Glu Pro Glu Glu Glu Glu Pro Asp Glu Ser Met Leu Asp 
545                 550                 555                 560 


Trp Trp Ser Lys Tyr Phe Ala Ser Ile Asp Thr Met Lys Glu Gln Leu 
                565                 570                 575     


Arg Gln Gln Glu Pro Ser Gly Ile Asp Leu Glu Glu Lys Glu Glu Val 
            580                 585                 590         


Asp Asn Thr Glu Gly Leu Lys Gly Ser Met Lys Gly Lys Glu Lys Ala 
        595                 600                 605             


Arg Ala Ala Lys Glu Glu Lys Lys Lys Lys Thr Gln Ser Ser Gly Ser 
    610                 615                 620                 


Gly Gln Gly Ser Glu Ala Pro Glu Lys Lys Lys Pro Lys Ile Asp Glu 
625                 630                 635                 640 


Leu Lys Val Tyr Pro Lys Glu Leu Glu Ser Glu Phe Asp Asn Phe Glu 
                645                 650                 655     


Asp Trp Leu His Thr Phe Asn Leu Leu Arg Gly Lys Thr Gly Asp Asp 
            660                 665                 670         


Glu Asp Gly Ser Thr Glu Glu Glu Arg Ile Val Gly Arg Phe Lys Gly 
        675                 680                 685             


Ser Leu Cys Val Tyr Lys Val Pro Leu Pro Glu Asp Val Ser Arg Glu 
    690                 695                 700                 


Ala Gly Tyr Asp Ser Thr Tyr Gly Met Phe Gln Gly Ile Pro Ser Asn 
705                 710                 715                 720 


Asp Pro Ile Asn Val Leu Val Arg Val Tyr Val Val Arg Ala Thr Asp 
                725                 730                 735     


Leu His Pro Ala Asp Ile Asn Gly Lys Ala Asp Pro Tyr Ile Ala Ile 
            740                 745                 750         


Arg Leu Gly Lys Thr Asp Ile Arg Asp Lys Glu Asn Tyr Ile Ser Lys 
        755                 760                 765             


Gln Leu Asn Pro Val Phe Gly Lys Ser Phe Asp Ile Glu Ala Ser Phe 
    770                 775                 780                 


Pro Met Glu Ser Met Leu Thr Val Ala Val Tyr Asp Trp Asp Leu Val 
785                 790                 795                 800 


Gly Thr Asp Asp Leu Ile Gly Glu Thr Lys Ile Asp Leu Glu Asn Arg 
                805                 810                 815     


Phe Tyr Ser Lys His Arg Ala Thr Cys Gly Ile Ala Gln Thr Tyr Ser 
            820                 825                 830         


Thr His Gly Tyr Asn Ile Trp Arg Asp Pro Met Lys Pro Ser Gln Ile 
        835                 840                 845             


Leu Thr Arg Leu Cys Lys Asp Gly Lys Val Asp Gly Pro His Phe Gly 
    850                 855                 860                 


Pro Pro Gly Arg Val Lys Val Ala Asn Arg Val Phe Thr Gly Pro Ser 
865                 870                 875                 880 


Glu Ile Glu Asp Glu Asn Gly Gln Arg Lys Pro Thr Asp Glu His Val 
                885                 890                 895     


Ala Leu Leu Ala Leu Arg His Trp Glu Asp Ile Pro Arg Ala Gly Cys 
            900                 905                 910         


Arg Leu Val Pro Glu His Val Glu Thr Arg Pro Leu Leu Asn Pro Asp 
        915                 920                 925             


Lys Pro Gly Ile Glu Gln Gly Arg Leu Glu Leu Trp Val Asp Met Phe 
    930                 935                 940                 


Pro Met Asp Met Pro Ala Pro Gly Thr Pro Leu Asp Ile Ser Pro Arg 
945                 950                 955                 960 


Lys Pro Lys Lys Tyr Glu Leu Arg Val Ile Ile Trp Asn Thr Asp Glu 
                965                 970                 975     


Val Val Leu Glu Asp Asp Asp Phe Phe Thr Gly Glu Lys Ser Ser Asp 
            980                 985                 990         


Ile Phe Val Arg Gly Trp Leu Lys  Gly Gln Gln Glu Asp  Lys Gln Asp 
        995                 1000                 1005             


Thr Asp  Val His Tyr His Ser  Leu Thr Gly Glu Gly  Asn Phe Asn 
    1010                 1015                 1020             


Trp Arg  Tyr Leu Phe Pro Phe  Asp Tyr Leu Ala Ala  Glu Glu Lys 
    1025                 1030                 1035             


Ile Val  Ile Ser Lys Lys Glu  Ser Met Phe Ser Trp  Asp Glu Thr 
    1040                 1045                 1050             


Glu Tyr  Lys Ile Pro Ala Arg  Leu Thr Leu Gln Ile  Trp Asp Ala 
    1055                 1060                 1065             


Asp His  Phe Ser Ala Asp Asp  Phe Leu Gly Ala Ile  Glu Leu Asp 
    1070                 1075                 1080             


Leu Asn  Arg Phe Pro Arg Gly  Ala Lys Thr Ala Lys  Gln Cys Thr 
    1085                 1090                 1095             


Met Glu  Met Ala Thr Gly Glu  Val Asp Val Pro Leu  Val Ser Ile 
    1100                 1105                 1110             


Phe Lys  Gln Lys Arg Val Lys  Gly Trp Trp Pro Leu  Leu Ala Arg 
    1115                 1120                 1125             


Asn Glu  Asn Asp Glu Phe Glu  Leu Thr Gly Lys Val  Glu Ala Glu 
    1130                 1135                 1140             


Leu His  Leu Leu Thr Ala Glu  Glu Ala Glu Lys Asn  Pro Val Gly 
    1145                 1150                 1155             


Leu Ala  Arg Asn Glu Pro Asp  Pro Leu Glu Lys Pro  Asn Arg Pro 
    1160                 1165                 1170             


Asp Thr  Ser Phe Ile Trp Phe  Leu Asn Pro Leu Lys  Ser Ala Arg 
    1175                 1180                 1185             


Tyr Phe  Leu Trp His Thr Tyr  Arg Trp Leu Leu Leu  Lys Leu Leu 
    1190                 1195                 1200             


Leu Leu  Leu Leu Leu Leu Leu  Leu Leu Ala Leu Phe  Leu Tyr Ser 
    1205                 1210                 1215             


Val Pro  Gly Tyr Leu Val Lys  Lys Ile Leu Gly Ala  
    1220                 1225                 1230 


<210>  7
<211>  1992
<212>  PRT
<213>  musc musculus

<400>  7

Met Ala Leu Ile Val His Leu Lys Thr Val Ser Glu Leu Arg Gly Lys 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Gly Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Val Leu Glu Ile 
    50                  55                  60                  


Gln Ile Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Cys Met Val Leu Gln Lys Val Val Glu Glu Asn Arg Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Met Asp Asp Ser Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Ser Met Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Pro Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Lys Asp 
    130                 135                 140                 


Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Thr Arg 
145                 150                 155                 160 


Ile Ser Gly Glu Lys Ser Phe Arg Ser Lys Gly Arg Glu Lys Thr Lys 
                165                 170                 175     


Gly Gly Arg Asp Gly Glu His Lys Ala Gly Arg Ser Val Phe Ser Ala 
            180                 185                 190         


Met Lys Leu Gly Lys Thr Arg Ser His Lys Glu Glu Pro Gln Arg Gln 
        195                 200                 205             


Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu Ala Ile 
    210                 215                 220                 


Gln Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala Ser Val 
225                 230                 235                 240 


Thr Ala Leu Thr Ser Asn Val Ser Asn Lys Arg Ser Lys Pro Asp Ile 
                245                 250                 255     


Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val Ser Ile 
            260                 265                 270         


Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp Pro Val 
        275                 280                 285             


Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met Lys Glu 
    290                 295                 300                 


Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp Phe His 
305                 310                 315                 320 


Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser Val Ile 
                325                 330                 335     


His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser Phe Lys 
            340                 345                 350         


Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe His His 
        355                 360                 365             


Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ala Gly Leu Lys 
    370                 375                 380                 


Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp Asn Ile 
385                 390                 395                 400 


Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile Glu Gly 
                405                 410                 415     


Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp Ala Arg 
            420                 425                 430         


Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met Asn Thr 
        435                 440                 445             


Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn Lys Asp 
    450                 455                 460                 


Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys Gly Lys 
465                 470                 475                 480 


Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu Gln Val 
                485                 490                 495     


Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys Val Gln 
            500                 505                 510         


Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr His Phe 
        515                 520                 525             


Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe Leu Pro 
    530                 535                 540                 


Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg Asn Tyr 
545                 550                 555                 560 


Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly Glu Gly 
                565                 570                 575     


Val Ser Phe Arg Ala Arg Leu Met Leu Gly Leu Ala Val Glu Ile Leu 
            580                 585                 590         


Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln Val Glu 
        595                 600                 605             


Gln Ala Thr Pro Val Ser Glu Ser Cys Thr Gly Arg Met Glu Glu Phe 
    610                 615                 620                 


Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg Lys Asn 
625                 630                 635                 640 


Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr Gly Asn 
                645                 650                 655     


Glu Val Asp Gly Met Ser Arg Pro Leu Arg Pro Arg Pro Arg Lys Glu 
            660                 665                 670         


Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ser Ser Asp Asp 
        675                 680                 685             


Glu Gly Asp Glu Ala Gly Asp Leu Ala Ser Val Ser Ser Thr Pro Pro 
    690                 695                 700                 


Met Arg Pro Gln Ile Thr Asp Arg Asn Tyr Phe His Leu Pro Tyr Leu 
705                 710                 715                 720 


Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp Gln Arg 
                725                 730                 735     


Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp Lys Leu 
            740                 745                 750         


Glu Glu Gly Leu Asn Asp Val Gln Glu Met Ile Lys Thr Glu Lys Ser 
        755                 760                 765             


Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser Cys Gly 
    770                 775                 780                 


Cys His Arg Phe Leu Ser Leu Ser Asp Lys Asp Gln Gly Arg Ser Ser 
785                 790                 795                 800 


Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg Glu Leu 
                805                 810                 815     


Glu Ser Met Gly Gln Gln Ala Lys Ser Leu Arg Ala Gln Val Lys Arg 
            820                 825                 830         


His Thr Val Arg Asp Lys Leu Arg Ser Cys Gln Asn Phe Leu Gln Lys 
        835                 840                 845             


Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp Val Phe 
    850                 855                 860                 


Ile Trp Met Met Ser Asn Asn Lys Arg Ile Ala Tyr Ala Arg Val Pro 
865                 870                 875                 880 


Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Leu Gly Lys Asp 
                885                 890                 895     


Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys Arg Gly 
            900                 905                 910         


Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Leu Glu Leu Tyr Leu 
        915                 920                 925             


Trp Leu Gly Leu Ser Lys Gln Arg Lys Asp Phe Leu Cys Gly Leu Pro 
    930                 935                 940                 


Cys Gly Phe Glu Glu Val Lys Ala Ala Gln Gly Leu Gly Leu His Ser 
945                 950                 955                 960 


Phe Pro Pro Ile Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe Gln Leu 
                965                 970                 975     


Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp Ser Ser 
            980                 985                 990         


Gly Leu Ser Asp Pro Phe Ala Arg  Val Phe Phe Ile Asn  Gln Ser Gln 
        995                 1000                 1005             


Cys Thr  Glu Val Leu Asn Glu  Thr Leu Cys Pro Thr  Trp Asp Gln 
    1010                 1015                 1020             


Met Leu  Val Phe Asp Asn Leu  Glu Leu Tyr Gly Glu  Ala His Glu 
    1025                 1030                 1035             


Leu Arg  Asp Asp Pro Pro Ile  Ile Val Ile Glu Ile  Tyr Asp Gln 
    1040                 1045                 1050             


Asp Ser  Met Gly Lys Ala Asp  Phe Met Gly Arg Thr  Phe Ala Lys 
    1055                 1060                 1065             


Pro Leu  Val Lys Met Ala Asp  Glu Ala Tyr Cys Pro  Pro Arg Phe 
    1070                 1075                 1080             


Pro Pro  Gln Leu Glu Tyr Tyr  Gln Ile Tyr Arg Gly  Ser Ala Thr 
    1085                 1090                 1095             


Ala Gly  Asp Leu Leu Ala Ala  Phe Glu Leu Leu Gln  Ile Gly Pro 
    1100                 1105                 1110             


Ser Gly  Lys Ala Asp Leu Pro  Pro Ile Asn Gly Pro  Val Asp Met 
    1115                 1120                 1125             


Asp Arg  Gly Pro Ile Met Pro  Val Pro Val Gly Ile  Arg Pro Val 
    1130                 1135                 1140             


Leu Ser  Lys Tyr Arg Val Glu  Val Leu Phe Trp Gly  Leu Arg Asp 
    1145                 1150                 1155             


Leu Lys  Arg Val Asn Leu Ala  Gln Val Asp Arg Pro  Arg Val Asp 
    1160                 1165                 1170             


Ile Glu  Cys Ala Gly Lys Gly  Val Gln Ser Ser Leu  Ile His Asn 
    1175                 1180                 1185             


Tyr Lys  Lys Asn Pro Asn Phe  Asn Thr Leu Val Lys  Trp Phe Glu 
    1190                 1195                 1200             


Val Asp  Leu Pro Glu Asn Glu  Leu Leu His Pro Pro  Leu Asn Ile 
    1205                 1210                 1215             


Arg Val  Val Asp Cys Arg Ala  Phe Gly Arg Tyr Thr  Leu Val Gly 
    1220                 1225                 1230             


Ser His  Ala Val Ser Ser Leu  Arg Arg Phe Ile Tyr  Arg Pro Pro 
    1235                 1240                 1245             


Asp Arg  Ser Ala Pro Asn Trp  Asn Thr Thr Gly Glu  Val Val Val 
    1250                 1255                 1260             


Ser Met  Glu Pro Glu Glu Pro  Val Lys Lys Leu Glu  Thr Met Val 
    1265                 1270                 1275             


Lys Leu  Asp Ala Thr Ser Asp  Ala Val Val Lys Val  Asp Val Ala 
    1280                 1285                 1290             


Glu Asp  Glu Lys Glu Arg Lys  Lys Lys Lys Lys Lys  Gly Pro Ser 
    1295                 1300                 1305             


Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu Ser Met  Leu Asp Trp 
    1310                 1315                 1320             


Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr Met Lys  Glu Gln Leu 
    1325                 1330                 1335             


Arg Gln  His Glu Thr Ser Gly  Thr Asp Leu Glu Glu  Lys Glu Glu 
    1340                 1345                 1350             


Met Glu  Ser Ala Glu Gly Leu  Lys Gly Pro Met Lys  Ser Lys Glu 
    1355                 1360                 1365             


Lys Ser  Arg Ala Ala Lys Glu  Glu Lys Lys Lys Lys  Asn Gln Ser 
    1370                 1375                 1380             


Pro Gly  Pro Gly Gln Gly Ser  Glu Ala Pro Glu Lys  Lys Lys Ala 
    1385                 1390                 1395             


Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys Glu Leu  Glu Ser Glu 
    1400                 1405                 1410             


Phe Asp  Ser Phe Glu Asp Trp  Leu His Thr Phe Asn  Leu Leu Arg 
    1415                 1420                 1425             


Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser Thr Glu  Glu Glu Arg 
    1430                 1435                 1440             


Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys Val Tyr  Lys Val Pro 
    1445                 1450                 1455             


Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly Tyr Asp  Pro Thr Tyr 
    1460                 1465                 1470             


Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp Pro Ile  Asn Val Leu 
    1475                 1480                 1485             


Val Arg  Ile Tyr Val Val Arg  Ala Thr Asp Leu His  Pro Ala Asp 
    1490                 1495                 1500             


Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala Ile Lys  Leu Gly Lys 
    1505                 1510                 1515             


Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile Ser Lys  Gln Leu Asn 
    1520                 1525                 1530             


Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu Ala Ser  Phe Pro Met 
    1535                 1540                 1545             


Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp Trp Asp  Leu Val Gly 
    1550                 1555                 1560             


Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile Asp Leu  Glu Asn Arg 
    1565                 1570                 1575             


Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly Ile Ala  Gln Thr Tyr 
    1580                 1585                 1590             


Ser Ile  His Gly Tyr Asn Ile  Trp Arg Asp Pro Met  Lys Pro Ser 
    1595                 1600                 1605             


Gln Ile  Leu Thr Arg Leu Cys  Lys Glu Gly Lys Val  Asp Gly Pro 
    1610                 1615                 1620             


His Phe  Gly Pro His Gly Arg  Val Arg Val Ala Asn  Arg Val Phe 
    1625                 1630                 1635             


Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn Gly Gln  Arg Lys Pro 
    1640                 1645                 1650             


Thr Asp  Glu His Val Ala Leu  Ser Ala Leu Arg His  Trp Glu Asp 
    1655                 1660                 1665             


Ile Pro  Arg Val Gly Cys Arg  Leu Val Pro Glu His  Val Glu Thr 
    1670                 1675                 1680             


Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly Ile Glu  Gln Gly Arg 
    1685                 1690                 1695             


Leu Glu  Leu Trp Val Asp Met  Phe Pro Met Asp Met  Pro Ala Pro 
    1700                 1705                 1710             


Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys Pro Lys  Lys Tyr Glu 
    1715                 1720                 1725             


Leu Arg  Val Ile Val Trp Asn  Thr Asp Glu Val Val  Leu Glu Asp 
    1730                 1735                 1740             


Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser Asp Ile  Phe Val Arg 
    1745                 1750                 1755             


Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys Gln Asp  Thr Asp Val 
    1760                 1765                 1770             


His Tyr  His Ser Leu Thr Gly  Glu Gly Asn Phe Asn  Trp Arg Tyr 
    1775                 1780                 1785             


Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu Glu Lys  Ile Val Met 
    1790                 1795                 1800             


Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp Glu Thr  Glu Tyr Lys 
    1805                 1810                 1815             


Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp Asp Ala  Asp His Phe 
    1820                 1825                 1830             


Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu Leu Asp  Leu Asn Arg 
    1835                 1840                 1845             


Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln Cys Thr  Met Glu Met 
    1850                 1855                 1860             


Ala Thr  Gly Glu Val Asp Val  Pro Leu Val Ser Ile  Phe Lys Gln 
    1865                 1870                 1875             


Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu Ala Arg  Asn Glu Asn 
    1880                 1885                 1890             


Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu Ala Glu  Leu His Leu 
    1895                 1900                 1905             


Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro Val Gly  Leu Ala Arg 
    1910                 1915                 1920             


Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn Arg Pro  Asp Thr Ala 
    1925                 1930                 1935             


Phe Val  Trp Phe Leu Asn Pro  Leu Lys Ser Ile Lys  Tyr Leu Ile 
    1940                 1945                 1950             


Cys Thr  Arg Tyr Lys Trp Leu  Ile Ile Lys Ile Val  Leu Ala Leu 
    1955                 1960                 1965             


Leu Gly  Leu Leu Met Leu Ala  Leu Phe Leu Tyr Ser  Leu Pro Gly 
    1970                 1975                 1980             


Tyr Met  Val Lys Lys Leu Leu  Gly Ala 
    1985                 1990         


<210>  8
<211>  650
<212>  DNA
<213>  artificial

<220>
<223>  Promoter CMV-beta actin = SmCBA

<400>  8
ggtaccctag ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg       60

agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc      120

gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt      180

gacgtcaatg ggtggactat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc      240

atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg      300

cccagtacat gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg      360

ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc tcccccccct      420

ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg atgggggcgg      480

gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg ggcggggcga      540

ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt ccttttatgg      600

cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg                 650


<210>  9
<211>  287
<212>  DNA
<213>  artificial

<220>
<223>  recombinogenic bridging sequence

<400>  9
ccccgggtgc gcggcgtcgg tggtgccggc ggggggcgcc aggtcgcagg cggtgtaggg       60

ctccaggcag gcggcgaagg ccatgacgtg cgctatgaag gtctgctcct gcacgccgtg      120

aaccaggtgc gcctgcgggc cgcgcgcgaa caccgccacg tcctcgcctg cgtgggtctc      180

ttcgtccagg ggcactgctg actgctgccg atactcgggg ctcccgctct cgctctcggt      240

aacatccggc cgggcgccgt ccttgagcac atagcctgga ccgtttc                    287


<210>  10
<211>  143
<212>  DNA
<213>  artificial

<220>
<223>  ITR from AAV2, 5' end

<400>  10
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttc                                              143


<210>  11
<211>  143
<212>  DNA
<213>  artificial

<220>
<223>  ITR from AAV2, 3'end

<400>  11
acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgc       60

ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc      120

gcgcagagag ggagtggcca acc                                              143


<210>  12
<211>  84
<212>  DNA
<213>  artificial

<220>
<223>  Splice donor site of the Alkaline Phosphatase

<400>  12
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctga                                              84


<210>  13
<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  Splice acceptor site of the alkaline phosphatase

<400>  13
taggcaccta ttggtcttac tgacatccac tttgcctttc tctccacag                   49


<210>  14
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  forward primer to amplify a 2676 bp intermediate fragment 
       (nucleotides 27 to 2702) of the otoferlin cDNA

<400>  14
tgtctcagag ctccgaggca                                                   20


<210>  15
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  reverse primer to amplify a 2676 bp intermediate fragment 
       (nucleotides 27 to 2702) of the otoferlin cDNA

<400>  15
atcgtggagg aggaactggg ca                                                22


<210>  16
<211>  6907
<212>  DNA
<213>  musc musculus

<400>  16
ttggttgcct tggtctctgt gggcagcagc aggaggaggc ggcagcagcc agagaagagg       60

gaggcgtgtg agccacactc caccagcgag cttcttcccg ctgctctgga actgcccagg      120

ctctccccac cagcatggcc ctgattgttc acctcaagac tgtctcagag ctccgaggca      180

aaggtgaccg gattgccaaa gtcactttcc gagggcagtc tttctactcc cgggtcctgg      240

agaactgcga gggtgtggct gactttgatg agacgttccg gtggccagtg gccagcagca      300

tcgaccggaa tgaagtgttg gagattcaga ttttcaacta cagcaaagtc ttcagcaaca      360

agctgatagg gaccttctgc atggtgctgc agaaagtggt ggaggagaat cgggtagagg      420

tgaccgacac gctgatggat gacagcaatg ctatcatcaa gaccagcctg agcatggagg      480

tccggtatca ggccacagat ggcactgtgg gcccctggga tgatggagac ttcctgggag      540

atgaatccct ccaggaggag aaggacagcc aggagacaga tgggctgcta cctggttccc      600

gacccagcac ccggatatct ggcgagaaga gctttcgcag caaaggcaga gagaagacca      660

agggaggcag agatggcgag cacaaagcgg gaaggagtgt gttctcggcc atgaaactcg      720

gcaaaactcg gtcccacaaa gaggagcccc aaagacaaga tgagccagca gtgctggaga      780

tggaggacct ggaccaccta gccattcagc tgggggatgg gctggatcct gactccgtgt      840

ctctagcctc ggtcaccgct ctcaccagca atgtctccaa caaacggtct aagccagata      900

ttaagatgga gcccagtgct ggaaggccca tggattacca ggtcagcatc acagtgattg      960

aggctcggca gctggtgggc ttgaacatgg accctgtggt gtgtgtggag gtgggtgatg     1020

acaagaaata cacgtcaatg aaggagtcca caaactgccc ttactacaac gagtactttg     1080

tcttcgactt ccatgtctct cctgatgtca tgtttgacaa gatcatcaag atctcggtta     1140

tccattctaa gaacctgctt cggagcggca ccctggtggg ttccttcaaa atggatgtgg     1200

ggactgtgta ttcccagcct gaacaccagt tccatcacaa atgggccatc ctgtcagacc     1260

ccgatgacat ctctgctggg ttgaagggtt atgtaaagtg tgatgtcgct gtggtgggca     1320

agggagacaa catcaagaca ccccacaagg ccaacgagac ggatgaggac gacattgaag     1380

ggaacttgct gctccccgag ggcgtgcccc ccgaacggca gtgggcacgg ttctatgtga     1440

aaatttaccg agcagaggga ctgccccgga tgaacacaag cctcatggcc aacgtgaaga     1500

aggcgttcat cggtgagaac aaggacctcg tcgaccccta tgtgcaagtc ttctttgctg     1560

gacaaaaggg caaaacatca gtgcagaaga gcagctatga gccgctatgg aatgagcagg     1620

tcgtcttcac agacttgttc cccccactct gcaaacgcat gaaggtgcag atccgggact     1680

ctgacaaggt caatgatgtg gccatcggca cccacttcat cgacctgcgc aagatttcca     1740

acgatggaga caaaggcttc ctgcctaccc tcggtccagc ctgggtgaac atgtacggct     1800

ccacgcgcaa ctacacactg ctggacgagc accaggactt gaatgaaggc ctgggggagg     1860

gtgtgtcctt ccgggcccgc ctcatgttgg gactagctgt ggagatcctg gacacctcca     1920

acccagagct caccagctcc acggaggtgc aggtggagca ggccacgcct gtctcggaga     1980

gctgcacagg gagaatggaa gaattttttc tatttggagc cttcttggaa gcctcaatga     2040

ttgaccggaa aaatggggac aagccaatta cctttgaggt gaccatagga aactacggca     2100

atgaagtcga tggtatgtcc cggcccctga ggcctcggcc ccggaaagag cctggggatg     2160

aagaagaggt agacctgatt cagaactcca gtgacgatga aggtgacgaa gccggggacc     2220

tggcctcggt gtcctccacc ccacctatgc ggccccagat cacggacagg aactatttcc     2280

acctgcccta cctggagcgc aagccctgca tctatatcaa gagctggtgg cctgaccaga     2340

ggcggcgcct ctacaatgcc aacatcatgg atcacattgc tgacaagctg gaagaaggcc     2400

tgaatgatgt acaggagatg atcaaaacgg agaagtccta cccggagcgc cgcctgcggg     2460

gtgtgctaga ggaactcagc tgtggctgcc accgcttcct ctccctctcg gacaaggacc     2520

agggccgctc gtcccgcacc aggctggatc gagagcgtct taagtcctgt atgagggagt     2580

tggagagcat gggacagcag gccaagagcc tgagggctca ggtgaagcgg cacactgttc     2640

gggacaagct gaggtcatgc cagaactttc tgcagaagct acgcttcctg gcggatgagc     2700

cccagcacag cattcctgat gtgttcattt ggatgatgag caacaacaaa cgtatcgcct     2760

atgcccgcgt gccttccaaa gacctgctct tctccatcgt ggaggaggaa ctgggcaagg     2820

actgcgccaa agtcaagacc ctcttcctga agctgccagg gaagaggggc ttcggctcgg     2880

caggctggac agtacaggcc aagctggagc tctacctgtg gctgggcctc agcaagcagc     2940

gaaaggactt cctgtgtggt ctgccctgtg gcttcgagga ggtcaaggca gcccaaggcc     3000

tgggcctgca ttcctttccg cccatcagcc tagtctacac caagaagcaa gccttccagc     3060

tccgagcaca catgtatcag gcccgaagcc tctttgctgc tgacagcagt gggctctctg     3120

atccctttgc ccgtgtcttc ttcatcaacc agagccaatg cactgaggtt ctaaacgaga     3180

cactgtgtcc cacctgggac cagatgctgg tatttgacaa cctggagctg tacggtgaag     3240

ctcacgagtt acgagatgat ccccccatca ttgtcattga aatctacgac caggacagca     3300

tgggcaaagc cgacttcatg ggccggacct tcgccaagcc cctggtgaag atggcagatg     3360

aagcatactg cccacctcgc ttcccgccgc agcttgagta ctaccagatc taccgaggca     3420

gtgccactgc cggagaccta ctggctgcct tcgagctgct gcagattggg ccatcaggga     3480

aggctgacct gccacccatc aatggcccag tggacatgga cagagggccc atcatgcctg     3540

tgcccgtggg aatccggcca gtgctcagca agtaccgagt ggaggtgctg ttctggggcc     3600

tgagggacct aaagagggtg aacctggccc aggtggaccg accacgggtg gacatcgagt     3660

gtgcaggaaa gggggtacaa tcctccctga ttcacaatta taagaagaac cccaacttca     3720

acacgctggt caagtggttt gaagtggacc tcccggagaa tgagctcctg cacccaccct     3780

tgaacatccg agtggtagat tgccgggcct ttggacgata caccctggtg ggttcccacg     3840

cagtcagctc actgaggcgc ttcatctacc gacctccaga ccgctcagcc cccaactgga     3900

acaccacagg ggaggttgta gtaagcatgg agcctgagga gccagttaag aagctggaga     3960

ccatggtgaa actggatgcg acttctgatg ctgtggtcaa ggtggatgtg gctgaagatg     4020

agaaggaaag gaagaagaag aaaaagaaag gcccgtcaga ggagccagag gaggaagagc     4080

ccgatgagag catgctggat tggtggtcca agtacttcgc ctccatcgac acaatgaagg     4140

agcaacttcg acaacatgag acctctggaa ctgacttgga agagaaggaa gagatggaaa     4200

gcgctgaggg cctgaaggga ccaatgaaga gcaaggagaa gtccagagct gcaaaggagg     4260

agaaaaagaa gaaaaaccag agccctggcc ctggccaggg atcggaggct cctgagaaga     4320

agaaagccaa gatcgatgag cttaaggtgt accccaagga gctggaatcg gagtttgaca     4380

gctttgagga ctggctgcac accttcaacc tgttgagggg caagacggga gatgatgagg     4440

atggctccac agaggaggag cgcatagtag gccgattcaa gggctccctc tgtgtgtaca     4500

aagtgccact cccagaagat gtatctcgag aagctggcta tgatcccacc tatggaatgt     4560

tccagggcat cccaagcaat gaccccatca atgtgctggt ccgaatctat gtggtccggg     4620

ccacagacct gcacccggcc gacatcaatg gcaaagctga cccctatatt gccatcaagt     4680

taggcaagac cgacatccga gacaaggaga actacatctc caagcagctc aaccctgtgt     4740

ttgggaagtc ctttgacatt gaggcctcct tccccatgga gtccatgttg acagtggccg     4800

tgtacgactg ggatctggtg ggcactgatg acctcatcgg agaaaccaag attgacctgg     4860

aaaaccgctt ctacagcaag catcgcgcca cctgcggcat cgcacagacc tattccatac     4920

atggctacaa tatctggagg gaccccatga agcccagcca gatcctgaca cgcctctgta     4980

aagagggcaa agtggacggc ccccactttg gtccccatgg gagagtgagg gttgccaacc     5040

gtgtcttcac ggggccttca gaaatagagg atgagaatgg tcagaggaag cccacagatg     5100

agcacgtggc actgtctgct ctgagacact gggaggacat cccccgggtg ggctgccgcc     5160

ttgtgccgga acacgtggag accaggccgc tgctcaaccc tgacaagcca ggcattgagc     5220

agggccgcct ggagctgtgg gtggacatgt tccccatgga catgccagcc cctgggacac     5280

ctctggatat atcccccagg aaacccaaga agtacgagct gcgggtcatc gtgtggaaca     5340

cagacgaggt ggtcctggaa gacgatgatt tcttcacggg agagaagtcc agtgacattt     5400

ttgtgagggg gtggctgaag ggccagcagg aggacaaaca ggacacagat gtccactatc     5460

actccctcac gggggagggc aacttcaact ggagatacct cttccccttc gactacctag     5520

cggccgaaga gaagatcgtt atgtccaaaa aggagtctat gttctcctgg gatgagacgg     5580

agtacaagat ccctgcgcgg ctcaccctgc agatctggga cgctgaccac ttctcggctg     5640

acgacttcct gggggctatc gagctggacc tgaaccggtt cccgaggggc gctaagacag     5700

ccaagcagtg caccatggag atggccaccg gggaggtgga cgtacccctg gtttccatct     5760

ttaaacagaa acgtgtcaaa ggctggtggc ccctcctggc ccgcaatgag aatgatgagt     5820

ttgagctcac aggcaaagtg gaggcggagc tacacctact cacggcagag gaggcagaga     5880

agaaccctgt gggcctggct cgcaatgaac ctgatcccct agaaaaaccc aaccggcctg     5940

acacggcatt cgtctggttc ctgaacccac tcaaatctat caagtacctc atctgcaccc     6000

ggtacaagtg gctgatcatc aagatcgtgc tggcgctgct ggggctgctc atgctggccc     6060

tcttccttta cagcctccca ggctacatgg tcaagaagct cctaggggcc tgaagtgtgc     6120

cccaccccag cccgctccag catccctcca ggggctgctg cgtattttgc cttccctcac     6180

ctggactctc tcccaactcc ctgaggagcc ctcccacgcc tgccagcctt gagcaagaca     6240

cctgcttgct ggacttcatc cccaccccac acccaaactg ttgcttgcct gatcttgtcc     6300

caggcctgcc tggggtttgg ggcacagttg gcctccaaaa ccagataccc tcttgtctaa     6360

agtaccaggt tcctctgccc aaccccaaga gtggtagtgg cccaaccctc cctgtgcttt     6420

ccaaatcttg tcttaaggca ccagtgaaat taaccaagaa acgcggagca atgcccaagg     6480

ctctgatgag taggaacacg tggaaagcac caggaatgcc agcagaggcg aggcggcaca     6540

cctctctgca gagcatccag gccgagcggc gggcagcggc cagctgcttc tgcgcatgct     6600

ctcctcttgg ctctgcttct ttctcacagt cacagtcact tcacagctta gccttgggct     6660

tcccatcact tccaggggtg cctctgcctt ggccagtgtg tgtcagctag tacacaagct     6720

ccaagtgtga atcaggtgta ctggccgtcc tgaagactga ctgccctgtc cttcctgccg     6780

acagccacac ccgagtgtac acttaaagcg gtgcccttct gcctctgtgg gcctgctggc     6840

tgctgttcct ttcttgagtg tgattttttt tttctctccc tcaataaaat aaatcaaact     6900

ctgagac                                                               6907


<210>  17
<211>  7009
<212>  DNA
<213>  artificial

<220>
<223>  pTR22-ITR-SmCBA-5'cDNA-otof-SD-RH-ITR

<400>  17
aggggggggg gggggggggt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc       60

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg      120

agcgcgcaga gagggagtgg ccaactccat cactaggggt tcctcagatc tggcgcgccc      180

aattcggtac cctagttatt aatagtaatc aattacgggg tcattagttc atagcccata      240

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      300

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      360

ccattgacgt caatgggtgg actatttacg gtaaactgcc cacttggcag tacatcaagt      420

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      480

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      540

catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc      600

cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg      660

ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg      720

ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt      780

tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgggagt      840

cgctgcgacg ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagcta gagcctctgc taaccatgtt catgccttct tctttttcct     1080

acagctcctg ggcaacgtgc tggttattgt gctgtctcat cattttggca aagaattcta     1140

gcggccgcca ccatggccct gattgttcac ctcaagactg tctcagagct ccgaggcaaa     1200

ggtgaccgga ttgccaaagt cactttccga gggcagtctt tctactcccg ggtcctggag     1260

aactgcgagg gtgtggctga ctttgatgag acgttccggt ggccagtggc cagcagcatc     1320

gaccggaatg aagtgttgga gattcagatt ttcaactaca gcaaagtctt cagcaacaag     1380

ctgataggga ccttctgcat ggtgctgcag aaagtggtgg aggagaatcg ggtagaggtg     1440

accgacacgc tgatggatga cagcaatgct atcatcaaga ccagcctgag catggaggtc     1500

cggtatcagg ccacagatgg cactgtgggc ccctgggatg atggagactt cctgggagat     1560

gaatccctcc aggaggagaa ggacagccag gagacagatg ggctgctacc tggttcccga     1620

cccagcaccc ggatatctgg cgagaagagc tttcgcagca aaggcagaga gaagaccaag     1680

ggaggcagag atggcgagca caaagcggga aggagtgtgt tctcggccat gaaactcggc     1740

aaaactcggt cccacaaaga ggagccccaa agacaagatg agccagcagt gctggagatg     1800

gaggacctgg accacctagc cattcagctg ggggatgggc tggatcctga ctccgtgtct     1860

ctagcctcgg tcaccgctct caccagcaat gtctccaaca aacggtctaa gccagatatt     1920

aagatggagc ccagtgctgg aaggcccatg gattaccagg tcagcatcac agtgattgag     1980

gctcggcagc tggtgggctt gaacatggac cctgtggtgt gtgtggaggt gggtgatgac     2040

aagaaataca cgtcaatgaa ggagtccaca aactgccctt actacaacga gtactttgtc     2100

ttcgacttcc atgtctctcc tgatgtcatg tttgacaaga tcatcaagat ctcggttatc     2160

cattctaaga acctgcttcg gagcggcacc ctggtgggtt ccttcaaaat ggatgtgggg     2220

actgtgtatt cccagcctga acaccagttc catcacaaat gggccatcct gtcagacccc     2280

gatgacatct ctgctgggtt gaagggttat gtaaagtgtg atgtcgctgt ggtgggcaag     2340

ggagacaaca tcaagacacc ccacaaggcc aacgagacgg atgaggacga cattgaaggg     2400

aacttgctgc tccccgaggg cgtgcccccc gaacggcagt gggcacggtt ctatgtgaaa     2460

atttaccgag cagagggact gccccggatg aacacaagcc tcatggccaa cgtgaagaag     2520

gcgttcatcg gtgagaacaa ggacctcgtc gacccctatg tgcaagtctt ctttgctgga     2580

caaaagggca aaacatcagt gcagaagagc agctatgagc cgctatggaa tgagcaggtc     2640

gtcttcacag acttgttccc cccactctgc aaacgcatga aggtgcagat ccgggactct     2700

gacaaggtca atgatgtggc catcggcacc cacttcatcg acctgcgcaa gatttccaac     2760

gatggagaca aaggcttcct gcctaccctc ggtccagcct gggtgaacat gtacggctcc     2820

acgcgcaact acacactgct ggacgagcac caggacttga atgaaggcct gggggagggt     2880

gtgtccttcc gggcccgcct catgttggga ctagctgtgg agatcctgga cacctccaac     2940

ccagagctca ccagctccac ggaggtgcag gtggagcagg ccacgcctgt ctcggagagc     3000

tgcacaggga gaatggaaga attttttcta tttggagcct tcttggaagc ctcaatgatt     3060

gaccggaaaa atggggacaa gccaattacc tttgaggtga ccataggaaa ctacggcaat     3120

gaagtcgatg gtatgtcccg gcccctgagg cctcggcccc ggaaagagcc tggggatgaa     3180

gaagaggtag acctgattca gaactccagt gacgatgaag gtgacgaagc cggggacctg     3240

gcctcggtgt cctccacccc acctatgcgg ccccagatca cggacaggaa ctatttccac     3300

ctgccctacc tggagcgcaa gccctgcatc tatatcaaga gctggtggcc tgaccagagg     3360

cggcgcctct acaatgccaa catcatggat cacattgctg acaagctgga agaaggcctg     3420

aatgatgtac aggagatgat caaaacggag aagtcctacc cggagcgccg cctgcggggt     3480

gtgctagagg aactcagctg tggctgccac cgcttcctct ccctctcgga caaggaccag     3540

ggccgctcgt cccgcaccag gctggatcga gagcgtctta agtcctgtat gagggagttg     3600

gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga     3660

cagagaagac tcttgcgttt ctgagctagc ccccgggtgc gcggcgtcgg tggtgccggc     3720

ggggggcgcc aggtcgcagg cggtgtaggg ctccaggcag gcggcgaagg ccatgacgtg     3780

cgctatgaag gtctgctcct gcacgccgtg aaccaggtgc gcctgcgggc cgcgcgcgaa     3840

caccgccacg tcctcgcctg cgtgggtctc ttcgtccagg ggcactgctg actgctgccg     3900

atactcgggg ctcccgctct cgctctcggt aacatccggc cgggcgccgt ccttgagcac     3960

atagcctgga ccgtttcgtc gactgttaat taagcatgct ggggagagat ctaggaaccc     4020

ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga ggccgcccgg     4080

gcaaagcccg ggcgtcgggc gacctttggt cgcccggcct cagtgagcga gcgagcgcgc     4140

agagagggag tggccaaccc cccccccccc ccccctgcag ccctgcatta atgaatcggc     4200

caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac     4260

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata     4320

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa     4380

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct     4440

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa     4500

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg     4560

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcaatgctca     4620

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa     4680

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg     4740

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg     4800

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaagg     4860

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc     4920

tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag     4980

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac     5040

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc     5100

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag     5160

taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt     5220

ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag     5280

ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca     5340

gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact     5400

ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca     5460

gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg     5520

tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc     5580

atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg     5640

gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca     5700

tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt     5760

atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc     5820

agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc     5880

ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca     5940

tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa     6000

aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat     6060

tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa     6120

aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga cgtctaagaa     6180

accattatta tcatgacatt aacctataaa aataggcgta tcacgaggcc ctttcgtctc     6240

gcgcgtttcg gtgatgacgg tgaaaacctc tgacacatgc agctcccgga gacggtcaca     6300

gcttgtctgt aagcggatgc cgggagcaga caagcccgtc agggcgcgtc agcgggtgtt     6360

ggcgggtgtc ggggctggct taactatgcg gcatcagagc agattgtact gagagtgcac     6420

catatgcggt gtgaaatacc gcacagatgc gtaaggagaa aataccgcat caggaaattg     6480

taaacgttaa tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta     6540

accaataggc cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt     6600

tgagtgttgt tccagtttgg aacaagagtc cactattaaa gaacgtggac tccaacgtca     6660

aagggcgaaa aaccgtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa     6720

gttttttggg gtcgaggtgc cgtaaagcac taaatcggaa ccctaaaggg agcccccgat     6780

ttagagcttg acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag     6840

gagcgggcgc tagggcgctg gcaagtgtag cggtcacgct gcgcgtaacc accacacccg     6900

ccgcgcttaa tgcgccgcta cagggcgcgt cgcgccattc gccattcagg ctacgcaact     6960

gttgggaagg gcgatcggtg cgggcctctt cgctattacg ccaggctgc                 7009


<210>  18
<211>  7413
<212>  DNA
<213>  artificial

<220>
<223>  pTR22-ITR-RH-SA- 3'cDNAerlin-polyA-ITR

<400>  18
aggggggggg gggggggggt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc       60

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg      120

agcgcgcaga gagggagtgg ccaactccat cactaggggt tcctcagatc tggcgcgccc      180

aattggcttc gaattctagc ggccgccccc gggtgcgcgg cgtcggtggt gccggcgggg      240

ggcgccaggt cgcaggcggt gtagggctcc aggcaggcgg cgaaggccat gacgtgcgct      300

atgaaggtct gctcctgcac gccgtgaacc aggtgcgcct gcgggccgcg cgcgaacacc      360

gccacgtcct cgcctgcgtg ggtctcttcg tccaggggca ctgctgactg ctgccgatac      420

tcggggctcc cgctctcgct ctcggtaaca tccggccggg cgccgtcctt gagcacatag      480

cctggaccgt ttccttaagc gacgcatgct cgcgataggc acctattggt cttactgaca      540

tccactttgc ctttctctcc acaggagagc atgggacagc aggccaagag cctgagggct      600

caggtgaagc ggcacactgt tcgggacaag ctgaggtcat gccagaactt tctgcagaag      660

ctacgcttcc tggcggatga gccccagcac agcattcctg atgtgttcat ttggatgatg      720

agcaacaaca aacgtatcgc ctatgcccgc gtgccttcca aagacctgct cttctccatc      780

gtggaggagg aactgggcaa ggactgcgcc aaagtcaaga ccctcttcct gaagctgcca      840

gggaagaggg gcttcggctc ggcaggctgg acagtacagg ccaagctgga gctctacctg      900

tggctgggcc tcagcaagca gcgaaaggac ttcctgtgtg gtctgccctg tggcttcgag      960

gaggtcaagg cagcccaagg cctgggcctg cattcctttc cgcccatcag cctagtctac     1020

accaagaagc aagccttcca gctccgagca cacatgtatc aggcccgaag cctctttgct     1080

gctgacagca gtgggctctc tgatcccttt gcccgtgtct tcttcatcaa ccagagccaa     1140

tgcactgagg ttctaaacga gacactgtgt cccacctggg accagatgct ggtatttgac     1200

aacctggagc tgtacggtga agctcacgag ttacgagatg atccccccat cattgtcatt     1260

gaaatctacg accaggacag catgggcaaa gccgacttca tgggccggac cttcgccaag     1320

cccctggtga agatggcaga tgaagcatac tgcccacctc gcttcccgcc gcagcttgag     1380

tactaccaga tctaccgagg cagtgccact gccggagacc tactggctgc cttcgagctg     1440

ctgcagattg ggccatcagg gaaggctgac ctgccaccca tcaatggccc agtggacatg     1500

gacagagggc ccatcatgcc tgtgcccgtg ggaatccggc cagtgctcag caagtaccga     1560

gtggaggtgc tgttctgggg cctgagggac ctaaagaggg tgaacctggc ccaggtggac     1620

cgaccacggg tggacatcga gtgtgcagga aagggggtac aatcctccct gattcacaat     1680

tataagaaga accccaactt caacacgctg gtcaagtggt ttgaagtgga cctcccggag     1740

aatgagctcc tgcacccacc cttgaacatc cgagtggtag attgccgggc ctttggacga     1800

tacaccctgg tgggttccca cgcagtcagc tcactgaggc gcttcatcta ccgacctcca     1860

gaccgctcag cccccaactg gaacaccaca ggggaggttg tagtaagcat ggagcctgag     1920

gagccagtta agaagctgga gaccatggtg aaactggatg cgacttctga tgctgtggtc     1980

aaggtggatg tggctgaaga tgagaaggaa aggaagaaga agaaaaagaa aggcccgtca     2040

gaggagccag aggaggaaga gcccgatgag agcatgctgg attggtggtc caagtacttc     2100

gcctccatcg acacaatgaa ggagcaactt cgacaacatg agacctctgg aactgacttg     2160

gaagagaagg aagagatgga aagcgctgag ggcctgaagg gaccaatgaa gagcaaggag     2220

aagtccagag ctgcaaagga ggagaaaaag aagaaaaacc agagccctgg ccctggccag     2280

ggatcggagg ctcctgagaa gaagaaagcc aagatcgatg agcttaaggt gtaccccaag     2340

gagctggaat cggagtttga cagctttgag gactggctgc acaccttcaa cctgttgagg     2400

ggcaagacgg gagatgatga ggatggctcc acagaggagg agcgcatagt aggccgattc     2460

aagggctccc tctgtgtgta caaagtgcca ctcccagaag atgtatctcg agaagctggc     2520

tatgatccca cctatggaat gttccagggc atcccaagca atgaccccat caatgtgctg     2580

gtccgaatct atgtggtccg ggccacagac ctgcacccgg ccgacatcaa tggcaaagct     2640

gacccctata ttgccatcaa gttaggcaag accgacatcc gagacaagga gaactacatc     2700

tccaagcagc tcaaccctgt gtttgggaag tcctttgaca ttgaggcctc cttccccatg     2760

gagtccatgt tgacagtggc cgtgtacgac tgggatctgg tgggcactga tgacctcatc     2820

ggagaaacca agattgacct ggaaaaccgc ttctacagca agcatcgcgc cacctgcggc     2880

atcgcacaga cctattccat acatggctac aatatctgga gggaccccat gaagcccagc     2940

cagatcctga cacgcctctg taaagagggc aaagtggacg gcccccactt tggtccccat     3000

gggagagtga gggttgccaa ccgtgtcttc acggggcctt cagaaataga ggatgagaat     3060

ggtcagagga agcccacaga tgagcacgtg gcactgtctg ctctgagaca ctgggaggac     3120

atcccccggg tgggctgccg ccttgtgccg gaacacgtgg agaccaggcc gctgctcaac     3180

cctgacaagc caggcattga gcagggccgc ctggagctgt gggtggacat gttccccatg     3240

gacatgccag cccctgggac acctctggat atatccccca ggaaacccaa gaagtacgag     3300

ctgcgggtca tcgtgtggaa cacagacgag gtggtcctgg aagacgatga tttcttcacg     3360

ggagagaagt ccagtgacat ttttgtgagg gggtggctga agggccagca ggaggacaaa     3420

caggacacag atgtccacta tcactccctc acgggggagg gcaacttcaa ctggagatac     3480

ctcttcccct tcgactacct agcggccgaa gagaagatcg ttatgtccaa aaaggagtct     3540

atgttctcct gggatgagac ggagtacaag atccctgcgc ggctcaccct gcagatctgg     3600

gacgctgacc acttctcggc tgacgacttc ctgggggcta tcgagctgga cctgaaccgg     3660

ttcccgaggg gcgctaagac agccaagcag tgcaccatgg agatggccac cggggaggtg     3720

gacgtacccc tggtttccat ctttaaacag aaacgtgtca aaggctggtg gcccctcctg     3780

gcccgcaatg agaatgatga gtttgagctc acaggcaaag tggaggcgga gctacaccta     3840

ctcacggcag aggaggcaga gaagaaccct gtgggcctgg ctcgcaatga acctgatccc     3900

ctagaaaaac ccaaccggcc tgacacggca ttcgtctggt tcctgaaccc actcaaatct     3960

atcaagtacc tcatctgcac ccggtacaag tggctgatca tcaagatcgt gctggcgctg     4020

ctggggctgc tcatgctggc cctcttcctt tacagcctcc caggctacat ggtcaagaag     4080

ctcctagggg cctgagcggc cgcggtacca agggcgaatt ctgcagtcga ctagagctcg     4140

ctgatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt     4200

gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat     4260

tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag     4320

caagggggag gattgggaag acaatagcag gcatgctggg gagagatctg aggactagtc     4380

cgtcgactgt taattaagca tgctggggag agatctagga acccctagtg atggagttgg     4440

ccactccctc tctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc     4500

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     4560

accccccccc ccccccccct gcagccctgc attaatgaat cggccaacgc gcggggagag     4620

gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg cgctcggtcg     4680

ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat     4740

caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta     4800

aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa     4860

atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc     4920

cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt     4980

ccgcctttct cccttcggga agcgtggcgc tttctcaatg ctcacgctgt aggtatctca     5040

gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg     5100

accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat     5160

cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta     5220

cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta tttggtatct     5280

gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac     5340

aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa     5400

aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa     5460

actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt     5520

taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca     5580

gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca     5640

tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc     5700

ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa     5760

accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc     5820

agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca     5880

acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat     5940

tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag     6000

cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac     6060

tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt     6120

ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt     6180

gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc     6240

tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat     6300

ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca     6360

gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga     6420

cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg     6480

gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg     6540

ttccgcgcac atttccccga aaagtgccac ctgacgtcta agaaaccatt attatcatga     6600

cattaaccta taaaaatagg cgtatcacga ggccctttcg tctcgcgcgt ttcggtgatg     6660

acggtgaaaa cctctgacac atgcagctcc cggagacggt cacagcttgt ctgtaagcgg     6720

atgccgggag cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg tgtcggggct     6780

ggcttaacta tgcggcatca gagcagattg tactgagagt gcaccatatg cggtgtgaaa     6840

taccgcacag atgcgtaagg agaaaatacc gcatcaggaa attgtaaacg ttaatatttt     6900

gttaaaattc gcgttaaatt tttgttaaat cagctcattt tttaaccaat aggccgaaat     6960

cggcaaaatc ccttataaat caaaagaata gaccgagata gggttgagtg ttgttccagt     7020

ttggaacaag agtccactat taaagaacgt ggactccaac gtcaaagggc gaaaaaccgt     7080

ctatcagggc gatggcccac tacgtgaacc atcaccctaa tcaagttttt tggggtcgag     7140

gtgccgtaaa gcactaaatc ggaaccctaa agggagcccc cgatttagag cttgacgggg     7200

aaagccggcg aacgtggcga gaaaggaagg gaagaaagcg aaaggagcgg gcgctagggc     7260

gctggcaagt gtagcggtca cgctgcgcgt aaccaccaca cccgccgcgc ttaatgcgcc     7320

gctacagggc gcgtcgcgcc attcgccatt caggctacgc aactgttggg aagggcgatc     7380

ggtgcgggcc tcttcgctat tacgccaggc tgc                                  7413


<210>  19
<211>  6967
<212>  DNA
<213>  artificial

<220>
<223>  pTR22-SmCBA-OtoferlinNT-SD-RH-ITR

<400>  19
aggggggggg gggggggggt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc       60

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg      120

agcgcgcaga gagggagtgg ccaactccat cactaggggt tcctcagatc tggcgcgccc      180

aattcggtac cctagttatt aatagtaatc aattacgggg tcattagttc atagcccata      240

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      300

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      360

ccattgacgt caatgggtgg actatttacg gtaaactgcc cacttggcag tacatcaagt      420

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      480

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      540

catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc      600

cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg      660

ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg      720

ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt      780

tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgggagt      840

cgctgcgacg ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc      900

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      960

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc     1020

ttgaggggct ccgggagcta gagcctctgc taaccatgtt catgccttct tctttttcct     1080

acagctcctg ggcaacgtgc tggttattgt gctgtctcat cattttggca aagaattcta     1140

gcggccgcca ccatggcctt gctcatccac ctcaagacag tctcggagct gcggggcagg     1200

ggcgaccgga tcgccaaagt gactttccga gggcaatcct tctactctcg ggtcctggag     1260

aactgtgagg atgtggctga ctttgatgag acatttcggt ggccggtggc cagcagcatc     1320

gacagaaatg agatgctgga gattcaggtt ttcaactaca gcaaagtctt cagcaacaag     1380

ctcatcggga ccttccgcat ggtgctgcag aaggtggtag aggagagcca tgtggaggtg     1440

actgacacgc tgattgatga caacaatgct atcatcaaga ccagcctgtg cgtggaggtc     1500

cggtatcagg ccactgacgg cacagtgggc tcctgggacg atggggactt cctgggagat     1560

gagtctcttc aagaggaaga gaaggacagc caagagacgg atggactgct cccaggctcc     1620

cggcccagct cccggccccc aggagagaag agcttccgga gagccgggag gagcgtgttc     1680

tccgccatga agctcggcaa aaaccggtct cacaaggagg agccccaaag accagatgaa     1740

ccggcggtgc tggagatgga agaccttgac catctggcca ttcggctagg agatggactg     1800

gatcccgact cggtgtctct agcctcagtc acagctctca ccactaatgt ctccaacaag     1860

cgatctaagc cagacattaa gatggagcca agtgctgggc ggcccatgga ttaccaggtc     1920

agcatcacgg tgatcgaggc ccggcagctg gtgggcttga acatggaccc tgtggtgtgc     1980

gtggaggtgg gtgacgacaa gaagtacaca tccatgaagg agtccactaa ctgcccctat     2040

tacaacgagt acttcgtctt cgacttccat gtctctccgg atgtcatgtt tgacaagatc     2100

atcaagattt cggtgattca ctccaagaac ctgctgcgca gtggcaccct ggtgggctcc     2160

ttcaaaatgg acgtgggaac cgtgtactcg cagccagagc accagttcca tcacaagtgg     2220

gccatcctgt ctgaccccga tgacatctcc tcggggctga agggctacgt gaagtgtgac     2280

gttgccgtgg tgggcaaagg ggacaacatc aagacgcccc acaaggccaa tgagaccgac     2340

gaagatgaca ttgaggggaa cttgctgctc cccgaggggg tgccccccga acgccagtgg     2400

gcccggttct atgtgaaaat ttaccgagca gaggggctgc cccgtatgaa cacaagcctc     2460

atggccaatg taaagaaggc tttcatcggt gaaaacaagg acctcgtgga cccctacgtg     2520

caagtcttct ttgctggcca gaagggcaag acttcagtgc agaagagcag ctatgagccc     2580

ctgtggaatg agcaggtcgt ctttacagac ctcttccccc cactctgcaa acgcatgaag     2640

gtgcagatcc gagactcgga caaggtcaac gacgtggcca tcggcaccca cttcattgac     2700

ctgcgcaaga tttctaatga cggagacaaa ggcttcctgc ccacactggg cccagcctgg     2760

gtgaacatgt acggctccac acgtaactac acgctgctgg atgagcatca ggacctgaac     2820

gagggcctgg gggagggtgt gtccttccgg gcccggctcc tgctgggcct ggctgtggag     2880

atcgtagaca cctccaaccc tgagctcacc agctccacag aggtgcaggt ggagcaggcc     2940

acgcccatct cggagagctg tgcaggtaaa atggaagaat tctttctctt tggagccttc     3000

ctggaggcct caatgatcga ccggagaaac ggagacaagc ccatcacctt tgaggtcacc     3060

ataggcaact atgggaacga agttgatggc ctgtcccggc cccagcggcc tcggccccgg     3120

aaggagccgg gggatgagga agaagtagac ctgattcaga acgcaagtga tgacgaggcc     3180

ggtgatgccg gggacctggc ctcagtctcc tccactccac caatgcggcc ccaggtcacc     3240

gacaggaact acttccatct gccctacctg gagcgaaagc cctgcatcta catcaagagc     3300

tggtggccgg accagcgccg ccgcctctac aatgccaaca tcatggacca cattgccgac     3360

aagctggaag aaggcctgaa cgacatacag gagatgatca aaacggagaa gtcctaccct     3420

gagcgtcgcc tgcggggcgt cctggaggag ctgagctgtg gctgctgccg cttcctctcc     3480

ctcgctgaca aggaccaggg ccactcatcc cgcaccaggc ttgaccggga gcgcctcaag     3540

tcctgcatga gggagctggt aagtatcaag gttacaagac aggtttaagg agaccaatag     3600

aaactgggct tgtcgagaca gagaagactc ttgcgtttct gagctagccc ccgggtgcgc     3660

ggcgtcggtg gtgccggcgg ggggcgccag gtcgcaggcg gtgtagggct ccaggcaggc     3720

ggcgaaggcc atgacgtgcg ctatgaaggt ctgctcctgc acgccgtgaa ccaggtgcgc     3780

ctgcgggccg cgcgcgaaca ccgccacgtc ctcgcctgcg tgggtctctt cgtccagggg     3840

cactgctgac tgctgccgat actcggggct cccgctctcg ctctcggtaa catccggccg     3900

ggcgccgtcc ttgagcacat agcctggacc gtttcgtcga ctgttaatta agcatgctgg     3960

ggagagatct aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     4020

ctcactgagg ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca     4080

gtgagcgagc gagcgcgcag agagggagtg gccaaccccc cccccccccc ccctgcagcc     4140

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     4200

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct     4260

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     4320

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     4380

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     4440

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     4500

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     4560

gcgctttctc aatgctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     4620

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     4680

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     4740

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     4800

tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc     4860

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt     4920

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc     4980

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg     5040

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca     5100

atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca     5160

cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag     5220

ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac     5280

ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc     5340

agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct     5400

agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc     5460

gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg     5520

cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc     5580

gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat     5640

tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag     5700

tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat     5760

aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg     5820

cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca     5880

cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga     5940

aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc     6000

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata     6060

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg     6120

ccacctgacg tctaagaaac cattattatc atgacattaa cctataaaaa taggcgtatc     6180

acgaggccct ttcgtctcgc gcgtttcggt gatgacggtg aaaacctctg acacatgcag     6240

ctcccggaga cggtcacagc ttgtctgtaa gcggatgccg ggagcagaca agcccgtcag     6300

ggcgcgtcag cgggtgttgg cgggtgtcgg ggctggctta actatgcggc atcagagcag     6360

attgtactga gagtgcacca tatgcggtgt gaaataccgc acagatgcgt aaggagaaaa     6420

taccgcatca ggaaattgta aacgttaata ttttgttaaa attcgcgtta aatttttgtt     6480

aaatcagctc attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag     6540

aatagaccga gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga     6600

acgtggactc caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg     6660

aaccatcacc ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc     6720

ctaaagggag cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg     6780

aagggaagaa agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc     6840

gcgtaaccac cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcg cgccattcgc     6900

cattcaggct acgcaactgt tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc     6960

aggctgc                                                               6967


<210>  20
<211>  7470
<212>  DNA
<213>  artificial

<220>
<223>  pTR22-ITR-RH-SA-OtoferlinCT-polyA-ITR

<400>  20
aggggggggg gggggggggt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc       60

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg      120

agcgcgcaga gagggagtgg ccaactccat cactaggggt tcctcagatc tggcgcgccc      180

aattggcttc gaattctagc ggccgccccc gggtgcgcgg cgtcggtggt gccggcgggg      240

ggcgccaggt cgcaggcggt gtagggctcc aggcaggcgg cgaaggccat gacgtgcgct      300

atgaaggtct gctcctgcac gccgtgaacc aggtgcgcct gcgggccgcg cgcgaacacc      360

gccacgtcct cgcctgcgtg ggtctcttcg tccaggggca ctgctgactg ctgccgatac      420

tcggggctcc cgctctcgct ctcggtaaca tccggccggg cgccgtcctt gagcacatag      480

cctggaccgt ttccttaagc gacgcatgct cgcgataggc acctattggt cttactgaca      540

tccactttgc ctttctctcc acaggaaaac atggggcagc aggccaggat gctgcgggcc      600

caggtgaagc ggcacacggt gcgggacaag ctgaggctgt gccagaactt cctgcagaag      660

ctgcgcttcc tggcggacga gccccagcac agcattcccg acatcttcat ctggatgatg      720

agcaacaaca agcgtgtcgc ctatgcccgt gtgccctcca aggacctgct cttctccatc      780

gtggaggagg agactggcaa ggactgcgcc aaggtcaaga cgctcttcct taagctgcca      840

gggaagcggg gcttcggctc ggcaggctgg acagtgcagg ccaaggtgga gctgtacctg      900

tggctgggcc tcagcaaaca gcgcaaggag ttcctgtgcg gcctgccctg tggcttccag      960

gaggtcaagg cagcccaggg cctgggcctg catgccttcc cacccgtcag cctggtctac     1020

accaagaagc aggcgttcca gctccgagcg cacatgtacc aggcccgcag cctctttgcc     1080

gccgacagca gcggactctc agaccccttt gcccgcgtct tcttcatcaa tcagagtcag     1140

tgcacagagg tgctgaatga gaccctgtgt cccacctggg accagatgct ggtgttcgac     1200

aacctggagc tctatggtga agctcatgag ctgagggacg atccgcccat cattgtcatt     1260

gaaatctatg accaggattc catgggcaaa gctgacttca tgggccggac cttcgccaaa     1320

cccctggtga agatggcaga cgaggcgtac tgcccacccc gcttcccacc tcagctcgag     1380

tactaccaga tctaccgtgg caacgccaca gctggagacc tgctggcggc cttcgagctg     1440

ctgcagattg gaccagcagg gaaggctgac ctgcccccca tcaatggccc ggtggacgtg     1500

gaccgaggtc ccatcatgcc cgtgcccatg ggcatccggc ccgtgctcag caagtaccga     1560

gtggaggtgc tgttctgggg cctacgggac ctaaagcggg tgaacctggc ccaggtggac     1620

cggccacggg tggacatcga gtgtgcaggg aagggggtgc agtcgtccct gatccacaat     1680

tataagaaga accccaactt caacaccctc gtcaagtggt ttgaagtgga cctcccagag     1740

aacgagctgc tgcacccgcc cttgaacatc cgtgtggtgg actgccgggc cttcggtcgc     1800

tacacactgg tgggctccca tgccgtcagc tccctgcgac gcttcatcta ccggccccca     1860

gaccgctcgg cccccagctg gaacaccacg gtcaggcttc tccggcgctg ccgtgtgctg     1920

tgcaatgggg gctcctcctc tcactccaca ggggaggttg tggtgactat ggagccagag     1980

gtacccatca agaaactgga gaccatggtg aagctggacg cgacttctga agctgttgtc     2040

aaggtggatg tggctgagga ggagaaggag aagaagaaga agaagaaggg cactgcggag     2100

gagccagagg aggaggagcc agacgagagc atgctggact ggtggtccaa gtactttgcc     2160

tccattgaca ccatgaagga gcaacttcga caacaagagc cctctggaat tgacttggag     2220

gagaaggagg aagtggacaa taccgagggc ctgaaggggt caatgaaggg caaggagaag     2280

gcaagggctg ccaaagagga gaagaagaag aaaactcaga gctctggctc tggccagggg     2340

tccgaggccc ccgagaagaa gaaacccaag attgatgagc ttaaggtata ccccaaagag     2400

ctggagtccg agtttgataa ctttgaggac tggctgcaca ctttcaactt gcttcggggc     2460

aagaccgggg atgatgagga tggctccacc gaggaggagc gcattgtggg acgcttcaag     2520

ggctccctct gcgtgtacaa agtgccactc ccagaggacg tgtcccggga agccggctac     2580

gactccacct acggcatgtt ccagggcatc ccgagcaatg accccatcaa tgtgctggtc     2640

cgagtctatg tggtccgggc cacggacctg caccctgctg acatcaacgg caaagctgac     2700

ccctacatcg ccatccggct aggcaagact gacatccgcg acaaggagaa ctacatctcc     2760

aagcagctca accctgtctt tgggaagtcc tttgacatcg aggcctcctt ccccatggaa     2820

tccatgctga cggtggctgt gtatgactgg gacctggtgg gcactgatga cctcattggg     2880

gaaaccaaga tcgacctgga gaaccgcttc tacagcaagc accgcgccac ctgcggcatc     2940

gcccagacct actccacaca tggctacaat atctggcggg accccatgaa gcccagccag     3000

atcctgaccc gcctctgcaa agacggcaaa gtggacggcc cccactttgg gccccctggg     3060

agagtgaagg tggccaaccg cgtcttcact gggccctctg agattgagga cgagaacggt     3120

cagaggaagc ccacagacga gcatgtggcg ctgttggccc tgaggcactg ggaggacatc     3180

ccccgcgcag gctgccgcct ggtgccagag catgtggaga cgaggccgct gctcaacccc     3240

gacaagccgg gcatcgagca gggccgcctg gagctgtggg tggacatgtt ccccatggac     3300

atgccagccc ctgggacgcc tctggacatc tcacctcgga agcccaagaa gtacgagctg     3360

cgggtcatca tctggaacac agatgaggtg gtcttggagg acgacgactt cttcacaggg     3420

gagaagtcca gtgacatctt cgtgaggggg tggctgaagg gccagcagga ggacaagcag     3480

gacacagacg tccactacca ctccctcact ggcgagggca acttcaactg gcgctacctg     3540

ttccccttcg actacctggc ggcggaggag aagatcgtca tctccaagaa ggagtccatg     3600

ttctcctggg acgagaccga gtacaagatc cccgcgcggc tcaccctgca gatctgggat     3660

gcggaccact tctccgctga cgacttcctg ggggccatcg agctggacct gaaccggttc     3720

ccgcggggcg caaagacagc caagcagtgc accatggaga tggccaccgg ggaggtggac     3780

gtgcccctcg tgtccatctt caagcaaaag cgcgtcaaag gctggtggcc cctcctggcc     3840

cgcaatgaga acgatgagtt tgagctcacg ggcaaggtgg aggctgagct gcatttactg     3900

acagcagagg aggcagagaa gaacccagtg ggcctggccc gcaatgaacc tgacccccta     3960

gagaaaccca accggcccga cacgagcttc atctggttcc tgaaccctct caagtcggct     4020

cgctacttct tgtggcacac gtatcgctgg ctgctcctca aactgttgct gctcctgctg     4080

ctgctcctcc tcctcgccct gttcctctac tctgtgcctg gctacctggt caagaaaatc     4140

ctcggggcct gagcggccgc ggtaccaagg gcgaattctg cagtcgacta gagctcgctg     4200

atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc     4260

ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc     4320

atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa     4380

gggggaggat tgggaagaca atagcaggca tgctggggag agatctgagg actagtccgt     4440

cgactgttaa ttaagcatgc tggggagaga tctaggaacc cctagtgatg gagttggcca     4500

ctccctctct gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg     4560

cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaacc     4620

cccccccccc cccccctgca gccctgcatt aatgaatcgg ccaacgcgcg gggagaggcg     4680

gtttgcgtat tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     4740

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     4800

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     4860

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     4920

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     4980

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     5040

cctttctccc ttcgggaagc gtggcgcttt ctcaatgctc acgctgtagg tatctcagtt     5100

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     5160

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     5220

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     5280

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg     5340

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     5400

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     5460

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     5520

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     5580

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     5640

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     5700

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     5760

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     5820

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     5880

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     5940

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     6000

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     6060

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     6120

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     6180

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     6240

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     6300

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca     6360

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg     6420

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac     6480

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt     6540

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc     6600

cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat     6660

taacctataa aaataggcgt atcacgaggc cctttcgtct cgcgcgtttc ggtgatgacg     6720

gtgaaaacct ctgacacatg cagctcccgg agacggtcac agcttgtctg taagcggatg     6780

ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt tggcgggtgt cggggctggc     6840

ttaactatgc ggcatcagag cagattgtac tgagagtgca ccatatgcgg tgtgaaatac     6900

cgcacagatg cgtaaggaga aaataccgca tcaggaaatt gtaaacgtta atattttgtt     6960

aaaattcgcg ttaaattttt gttaaatcag ctcatttttt aaccaatagg ccgaaatcgg     7020

caaaatccct tataaatcaa aagaatagac cgagataggg ttgagtgttg ttccagtttg     7080

gaacaagagt ccactattaa agaacgtgga ctccaacgtc aaagggcgaa aaaccgtcta     7140

tcagggcgat ggcccactac gtgaaccatc accctaatca agttttttgg ggtcgaggtg     7200

ccgtaaagca ctaaatcgga accctaaagg gagcccccga tttagagctt gacggggaaa     7260

gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa ggagcgggcg ctagggcgct     7320

ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc gccgcgctta atgcgccgct     7380

acagggcgcg tcgcgccatt cgccattcag gctacgcaac tgttgggaag ggcgatcggt     7440

gcgggcctct tcgctattac gccaggctgc                                      7470


<210>  21
<211>  7470
<212>  DNA
<213>  artificial

<220>
<223>  pTR22-ITR-RH-SA-OtoferlinCT-polyA-ITR

<400>  21
aggggggggg gggggggggt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc       60

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg      120

agcgcgcaga gagggagtgg ccaactccat cactaggggt tcctcagatc tggcgcgccc      180

aattggcttc gaattctagc ggccgccccc gggtgcgcgg cgtcggtggt gccggcgggg      240

ggcgccaggt cgcaggcggt gtagggctcc aggcaggcgg cgaaggccat gacgtgcgct      300

atgaaggtct gctcctgcac gccgtgaacc aggtgcgcct gcgggccgcg cgcgaacacc      360

gccacgtcct cgcctgcgtg ggtctcttcg tccaggggca ctgctgactg ctgccgatac      420

tcggggctcc cgctctcgct ctcggtaaca tccggccggg cgccgtcctt gagcacatag      480

cctggaccgt ttccttaagc gacgcatgct cgcgataggc acctattggt cttactgaca      540

tccactttgc ctttctctcc acaggaaaac atggggcagc aggccaggat gctgcgggcc      600

caggtgaagc ggcacacggt gcgggacaag ctgaggctgt gccagaactt cctgcagaag      660

ctgcgcttcc tggcggacga gccccagcac agcattcccg acatcttcat ctggatgatg      720

agcaacaaca agcgtgtcgc ctatgcccgt gtgccctcca aggacctgct cttctccatc      780

gtggaggagg agactggcaa ggactgcgcc aaggtcaaga cgctcttcct taagctgcca      840

gggaagcggg gcttcggctc ggcaggctgg acagtgcagg ccaaggtgga gctgtacctg      900

tggctgggcc tcagcaaaca gcgcaaggag ttcctgtgcg gcctgccctg tggcttccag      960

gaggtcaagg cagcccaggg cctgggcctg catgccttcc cacccgtcag cctggtctac     1020

accaagaagc aggcgttcca gctccgagcg cacatgtacc aggcccgcag cctctttgcc     1080

gccgacagca gcggactctc agaccccttt gcccgcgtct tcttcatcaa tcagagtcag     1140

tgcacagagg tgctgaatga gaccctgtgt cccacctggg accagatgct ggtgttcgac     1200

aacctggagc tctatggtga agctcatgag ctgagggacg atccgcccat cattgtcatt     1260

gaaatctatg accaggattc catgggcaaa gctgacttca tgggccggac cttcgccaaa     1320

cccctggtga agatggcaga cgaggcgtac tgcccacccc gcttcccacc tcagctcgag     1380

tactaccaga tctaccgtgg caacgccaca gctggagacc tgctggcggc cttcgagctg     1440

ctgcagattg gaccagcagg gaaggctgac ctgcccccca tcaatggccc ggtggacgtg     1500

gaccgaggtc ccatcatgcc cgtgcccatg ggcatccggc ccgtgctcag caagtaccga     1560

gtggaggtgc tgttctgggg cctacgggac ctaaagcggg tgaacctggc ccaggtggac     1620

cggccacggg tggacatcga gtgtgcaggg aagggggtgc agtcgtccct gatccacaat     1680

tataagaaga accccaactt caacaccctc gtcaagtggt ttgaagtgga cctcccagag     1740

aacgagctgc tgcacccgcc cttgaacatc cgtgtggtgg actgccgggc cttcggtcgc     1800

tacacactgg tgggctccca tgccgtcagc tccctgcgac gcttcatcta ccggccccca     1860

gaccgctcgg cccccagctg gaacaccacg gtcaggcttc tccggcgctg ccgtgtgctg     1920

tgcaatgggg gctcctcctc tcactccaca ggggaggttg tggtgactat ggagccagag     1980

gtacccatca agaaactgga gaccatggtg aagctggacg cgacttctga agctgttgtc     2040

aaggtggatg tggctgagga ggagaaggag aagaagaaga agaagaaggg cactgcggag     2100

gagccagagg aggaggagcc agacgagagc atgctggact ggtggtccaa gtactttgcc     2160

tccattgaca ccatgaagga gcaacttcga caacaagagc cctctggaat tgacttggag     2220

gagaaggagg aagtggacaa taccgagggc ctgaaggggt caatgaaggg caaggagaag     2280

gcaagggctg ccaaagagga gaagaagaag aaaactcaga gctctggctc tggccagggg     2340

tccgaggccc ccgagaagaa gaaacccaag attgatgagc ttaaggtata ccccaaagag     2400

ctggagtccg agtttgataa ctttgaggac tggctgcaca ctttcaactt gcttcggggc     2460

aagaccgggg atgatgagga tggctccacc gaggaggagc gcattgtggg acgcttcaag     2520

ggctccctct gcgtgtacaa agtgccactc ccagaggacg tgtcccggga agccggctac     2580

gactccacct acggcatgtt ccagggcatc ccgagcaatg accccatcaa tgtgctggtc     2640

cgagtctatg tggtccgggc cacggacctg caccctgctg acatcaacgg caaagctgac     2700

ccctacatcg ccatccggct aggcaagact gacatccgcg acaaggagaa ctacatctcc     2760

aagcagctca accctgtctt tgggaagtcc tttgacatcg aggcctcctt ccccatggaa     2820

tccatgctga cggtggctgt gtatgactgg gacctggtgg gcactgatga cctcattggg     2880

gaaaccaaga tcgacctgga gaaccgcttc tacagcaagc accgcgccac ctgcggcatc     2940

gcccagacct actccacaca tggctacaat atctggcggg accccatgaa gcccagccag     3000

atcctgaccc gcctctgcaa agacggcaaa gtggacggcc cccactttgg gccccctggg     3060

agagtgaagg tggccaaccg cgtcttcact gggccctctg agattgagga cgagaacggt     3120

cagaggaagc ccacagacga gcatgtggcg ctgttggccc tgaggcactg ggaggacatc     3180

ccccgcgcag gctgccgcct ggtgccagag catgtggaga cgaggccgct gctcaacccc     3240

gacaagccgg gcatcgagca gggccgcctg gagctgtggg tggacatgtt ccccatggac     3300

atgccagccc ctgggacgcc tctggacatc tcacctcgga agcccaagaa gtacgagctg     3360

cgggtcatca tctggaacac agatgaggtg gtcttggagg acgacgactt cttcacaggg     3420

gagaagtcca gtgacatctt cgtgaggggg tggctgaagg gccagcagga ggacaagcag     3480

gacacagacg tccactacca ctccctcact ggcgagggca acttcaactg gcgctacctg     3540

ttccccttcg actacctggc ggcggaggag aagatcgtca tctccaagaa ggagtccatg     3600

ttctcctggg acgagaccga gtacaagatc cccgcgcggc tcaccctgca gatctgggat     3660

gcggaccact tctccgctga cgacttcctg ggggccatcg agctggacct gaaccggttc     3720

ccgcggggcg caaagacagc caagcagtgc accatggaga tggccaccgg ggaggtggac     3780

gtgcccctcg tgtccatctt caagcaaaag cgcgtcaaag gctggtggcc cctcctggcc     3840

cgcaatgaga acgatgagtt tgagctcacg ggcaaggtgg aggctgagct gcatttactg     3900

acagcagagg aggcagagaa gaacccagtg ggcctggccc gcaatgaacc tgacccccta     3960

gagaaaccca accggcccga cacggccttc gtctggttcc tcaaccctct caagtccatc     4020

aagtacctca tctgcacccg gtacaagtgg ctcatcatca agatcgtgct ggcgctgttg     4080

gggctgctca tgttggggct cttcctctac agcctccctg gctacatggt caaaaagctc     4140

cttggggcat gagcggccgc ggtaccaagg gcgaattctg cagtcgacta gagctcgctg     4200

atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc     4260

ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc     4320

atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa     4380

gggggaggat tgggaagaca atagcaggca tgctggggag agatctgagg actagtccgt     4440

cgactgttaa ttaagcatgc tggggagaga tctaggaacc cctagtgatg gagttggcca     4500

ctccctctct gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg     4560

cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaacc     4620

cccccccccc cccccctgca gccctgcatt aatgaatcgg ccaacgcgcg gggagaggcg     4680

gtttgcgtat tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     4740

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     4800

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     4860

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     4920

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     4980

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     5040

cctttctccc ttcgggaagc gtggcgcttt ctcaatgctc acgctgtagg tatctcagtt     5100

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     5160

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     5220

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     5280

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg     5340

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     5400

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     5460

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     5520

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     5580

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     5640

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     5700

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     5760

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     5820

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     5880

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     5940

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     6000

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     6060

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     6120

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     6180

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     6240

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     6300

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca     6360

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg     6420

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac     6480

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt     6540

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc     6600

cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat     6660

taacctataa aaataggcgt atcacgaggc cctttcgtct cgcgcgtttc ggtgatgacg     6720

gtgaaaacct ctgacacatg cagctcccgg agacggtcac agcttgtctg taagcggatg     6780

ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt tggcgggtgt cggggctggc     6840

ttaactatgc ggcatcagag cagattgtac tgagagtgca ccatatgcgg tgtgaaatac     6900

cgcacagatg cgtaaggaga aaataccgca tcaggaaatt gtaaacgtta atattttgtt     6960

aaaattcgcg ttaaattttt gttaaatcag ctcatttttt aaccaatagg ccgaaatcgg     7020

caaaatccct tataaatcaa aagaatagac cgagataggg ttgagtgttg ttccagtttg     7080

gaacaagagt ccactattaa agaacgtgga ctccaacgtc aaagggcgaa aaaccgtcta     7140

tcagggcgat ggcccactac gtgaaccatc accctaatca agttttttgg ggtcgaggtg     7200

ccgtaaagca ctaaatcgga accctaaagg gagcccccga tttagagctt gacggggaaa     7260

gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa ggagcgggcg ctagggcgct     7320

ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc gccgcgctta atgcgccgct     7380

acagggcgcg tcgcgccatt cgccattcag gctacgcaac tgttgggaag ggcgatcggt     7440

gcgggcctct tcgctattac gccaggctgc                                      7470


<210>  22
<211>  6973
<212>  DNA
<213>  homo sapiens

<400>  22
atcggagggg ggtcgggagg aggaggagga ggcagcggca gagaagagag aggcgtgtga       60

gccgtgctcc accggctagc tccttcccgc tgctcctgcc tggcagtgcc aggcagccca      120

caccagcatg gccttgctca tccacctcaa gacagtctcg gagctgcggg gcaggggcga      180

ccggatcgcc aaagtgactt tccgagggca atccttctac tctcgggtcc tggagaactg      240

tgaggatgtg gctgactttg atgagacatt tcggtggccg gtggccagca gcatcgacag      300

aaatgagatg ctggagattc aggttttcaa ctacagcaaa gtcttcagca acaagctcat      360

cgggaccttc cgcatggtgc tgcagaaggt ggtagaggag agccatgtgg aggtgactga      420

cacgctgatt gatgacaaca atgctatcat caagaccagc ctgtgcgtgg aggtccggta      480

tcaggccact gacggcacag tgggctcctg ggacgatggg gacttcctgg gagatgagtc      540

tcttcaagag gaagagaagg acagccaaga gacggatgga ctgctcccag gctcccggcc      600

cagctcccgg cccccaggag agaagagctt ccggagagcc gggaggagcg tgttctccgc      660

catgaagctc ggcaaaaacc ggtctcacaa ggaggagccc caaagaccag atgaaccggc      720

ggtgctggag atggaagacc ttgaccatct ggccattcgg ctaggagatg gactggatcc      780

cgactcggtg tctctagcct cagtcacagc tctcaccact aatgtctcca acaagcgatc      840

taagccagac attaagatgg agccaagtgc tgggcggccc atggattacc aggtcagcat      900

cacggtgatc gaggcccggc agctggtggg cttgaacatg gaccctgtgg tgtgcgtgga      960

ggtgggtgac gacaagaagt acacatccat gaaggagtcc actaactgcc cctattacaa     1020

cgagtacttc gtcttcgact tccatgtctc tccggatgtc atgtttgaca agatcatcaa     1080

gatttcggtg attcactcca agaacctgct gcgcagtggc accctggtgg gctccttcaa     1140

aatggacgtg ggaaccgtgt actcgcagcc agagcaccag ttccatcaca agtgggccat     1200

cctgtctgac cccgatgaca tctcctcggg gctgaagggc tacgtgaagt gtgacgttgc     1260

cgtggtgggc aaaggggaca acatcaagac gccccacaag gccaatgaga ccgacgaaga     1320

tgacattgag gggaacttgc tgctccccga gggggtgccc cccgaacgcc agtgggcccg     1380

gttctatgtg aaaatttacc gagcagaggg gctgccccgt atgaacacaa gcctcatggc     1440

caatgtaaag aaggctttca tcggtgaaaa caaggacctc gtggacccct acgtgcaagt     1500

cttctttgct ggccagaagg gcaagacttc agtgcagaag agcagctatg agcccctgtg     1560

gaatgagcag gtcgtcttta cagacctctt ccccccactc tgcaaacgca tgaaggtgca     1620

gatccgagac tcggacaagg tcaacgacgt ggccatcggc acccacttca ttgacctgcg     1680

caagatttct aatgacggag acaaaggctt cctgcccaca ctgggcccag cctgggtgaa     1740

catgtacggc tccacacgta actacacgct gctggatgag catcaggacc tgaacgaggg     1800

cctgggggag ggtgtgtcct tccgggcccg gctcctgctg ggcctggctg tggagatcgt     1860

agacacctcc aaccctgagc tcaccagctc cacagaggtg caggtggagc aggccacgcc     1920

catctcggag agctgtgcag gtaaaatgga agaattcttt ctctttggag ccttcctgga     1980

ggcctcaatg atcgaccgga gaaacggaga caagcccatc acctttgagg tcaccatagg     2040

caactatggg aacgaagttg atggcctgtc ccggccccag cggcctcggc cccggaagga     2100

gccgggggat gaggaagaag tagacctgat tcagaacgca agtgatgacg aggccggtga     2160

tgccggggac ctggcctcag tctcctccac tccaccaatg cggccccagg tcaccgacag     2220

gaactacttc catctgccct acctggagcg aaagccctgc atctacatca agagctggtg     2280

gccggaccag cgccgccgcc tctacaatgc caacatcatg gaccacattg ccgacaagct     2340

ggaagaaggc ctgaacgaca tacaggagat gatcaaaacg gagaagtcct accctgagcg     2400

tcgcctgcgg ggcgtcctgg aggagctgag ctgtggctgc tgccgcttcc tctccctcgc     2460

tgacaaggac cagggccact catcccgcac caggcttgac cgggagcgcc tcaagtcctg     2520

catgagggag ctggaaaaca tggggcagca ggccaggatg ctgcgggccc aggtgaagcg     2580

gcacacggtg cgggacaagc tgaggctgtg ccagaacttc ctgcagaagc tgcgcttcct     2640

ggcggacgag ccccagcaca gcattcccga catcttcatc tggatgatga gcaacaacaa     2700

gcgtgtcgcc tatgcccgtg tgccctccaa ggacctgctc ttctccatcg tggaggagga     2760

gactggcaag gactgcgcca aggtcaagac gctcttcctt aagctgccag ggaagcgggg     2820

cttcggctcg gcaggctgga cagtgcaggc caaggtggag ctgtacctgt ggctgggcct     2880

cagcaaacag cgcaaggagt tcctgtgcgg cctgccctgt ggcttccagg aggtcaaggc     2940

agcccagggc ctgggcctgc atgccttccc acccgtcagc ctggtctaca ccaagaagca     3000

ggcgttccag ctccgagcgc acatgtacca ggcccgcagc ctctttgccg ccgacagcag     3060

cggactctca gacccctttg cccgcgtctt cttcatcaat cagagtcagt gcacagaggt     3120

gctgaatgag accctgtgtc ccacctggga ccagatgctg gtgttcgaca acctggagct     3180

ctatggtgaa gctcatgagc tgagggacga tccgcccatc attgtcattg aaatctatga     3240

ccaggattcc atgggcaaag ctgacttcat gggccggacc ttcgccaaac ccctggtgaa     3300

gatggcagac gaggcgtact gcccaccccg cttcccacct cagctcgagt actaccagat     3360

ctaccgtggc aacgccacag ctggagacct gctggcggcc ttcgagctgc tgcagattgg     3420

accagcaggg aaggctgacc tgccccccat caatggcccg gtggacgtgg accgaggtcc     3480

catcatgccc gtgcccatgg gcatccggcc cgtgctcagc aagtaccgag tggaggtgct     3540

gttctggggc ctacgggacc taaagcgggt gaacctggcc caggtggacc ggccacgggt     3600

ggacatcgag tgtgcaggga agggggtgca gtcgtccctg atccacaatt ataagaagaa     3660

ccccaacttc aacaccctcg tcaagtggtt tgaagtggac ctcccagaga acgagctgct     3720

gcacccgccc ttgaacatcc gtgtggtgga ctgccgggcc ttcggtcgct acacactggt     3780

gggctcccat gccgtcagct ccctgcgacg cttcatctac cggcccccag accgctcggc     3840

ccccagctgg aacaccacgg tcaggcttct ccggcgctgc cgtgtgctgt gcaatggggg     3900

ctcctcctct cactccacag gggaggttgt ggtgactatg gagccagagg tacccatcaa     3960

gaaactggag accatggtga agctggacgc gacttctgaa gctgttgtca aggtggatgt     4020

ggctgaggag gagaaggaga agaagaagaa gaagaagggc actgcggagg agccagagga     4080

ggaggagcca gacgagagca tgctggactg gtggtccaag tactttgcct ccattgacac     4140

catgaaggag caacttcgac aacaagagcc ctctggaatt gacttggagg agaaggagga     4200

agtggacaat accgagggcc tgaaggggtc aatgaagggc aaggagaagg caagggctgc     4260

caaagaggag aagaagaaga aaactcagag ctctggctct ggccaggggt ccgaggcccc     4320

cgagaagaag aaacccaaga ttgatgagct taaggtatac cccaaagagc tggagtccga     4380

gtttgataac tttgaggact ggctgcacac tttcaacttg cttcggggca agaccgggga     4440

tgatgaggat ggctccaccg aggaggagcg cattgtggga cgcttcaagg gctccctctg     4500

cgtgtacaaa gtgccactcc cagaggacgt gtcccgggaa gccggctacg actccaccta     4560

cggcatgttc cagggcatcc cgagcaatga ccccatcaat gtgctggtcc gagtctatgt     4620

ggtccgggcc acggacctgc accctgctga catcaacggc aaagctgacc cctacatcgc     4680

catccggcta ggcaagactg acatccgcga caaggagaac tacatctcca agcagctcaa     4740

ccctgtcttt gggaagtcct ttgacatcga ggcctccttc cccatggaat ccatgctgac     4800

ggtggctgtg tatgactggg acctggtggg cactgatgac ctcattgggg aaaccaagat     4860

cgacctggag aaccgcttct acagcaagca ccgcgccacc tgcggcatcg cccagaccta     4920

ctccacacat ggctacaata tctggcggga ccccatgaag cccagccaga tcctgacccg     4980

cctctgcaaa gacggcaaag tggacggccc ccactttggg ccccctggga gagtgaaggt     5040

ggccaaccgc gtcttcactg ggccctctga gattgaggac gagaacggtc agaggaagcc     5100

cacagacgag catgtggcgc tgttggccct gaggcactgg gaggacatcc cccgcgcagg     5160

ctgccgcctg gtgccagagc atgtggagac gaggccgctg ctcaaccccg acaagccggg     5220

catcgagcag ggccgcctgg agctgtgggt ggacatgttc cccatggaca tgccagcccc     5280

tgggacgcct ctggacatct cacctcggaa gcccaagaag tacgagctgc gggtcatcat     5340

ctggaacaca gatgaggtgg tcttggagga cgacgacttc ttcacagggg agaagtccag     5400

tgacatcttc gtgagggggt ggctgaaggg ccagcaggag gacaagcagg acacagacgt     5460

ccactaccac tccctcactg gcgagggcaa cttcaactgg cgctacctgt tccccttcga     5520

ctacctggcg gcggaggaga agatcgtcat ctccaagaag gagtccatgt tctcctggga     5580

cgagaccgag tacaagatcc ccgcgcggct caccctgcag atctgggatg cggaccactt     5640

ctccgctgac gacttcctgg gggccatcga gctggacctg aaccggttcc cgcggggcgc     5700

aaagacagcc aagcagtgca ccatggagat ggccaccggg gaggtggacg tgcccctcgt     5760

gtccatcttc aagcaaaagc gcgtcaaagg ctggtggccc ctcctggccc gcaatgagaa     5820

cgatgagttt gagctcacgg gcaaggtgga ggctgagctg catttactga cagcagagga     5880

ggcagagaag aacccagtgg gcctggcccg caatgaacct gaccccctag agaaacccaa     5940

ccggcccgac acggccttcg tctggttcct caaccctctc aagtccatca agtacctcat     6000

ctgcacccgg tacaagtggc tcatcatcaa gatcgtgctg gcgctgttgg ggctgctcat     6060

gttggggctc ttcctctaca gcctccctgg ctacatggtc aaaaagctcc ttggggcatg     6120

aaggccgcca gctcccgcca gccgctcccc agccctgccg catttccttt cagtggcttg     6180

gactctttcc catctcccct ggggagcctg aggagcccag cgtccactct tcatgccttg     6240

ggccgagcct gcctcctgct tgcgggggcc gcctgtcctc actgccccag gctgcggctt     6300

gcccagtccc gcccctctga cccctgcctg tgggctgggg agccttggat ggggtgggga     6360

cctggaatgg gtctctcttg ccccacctgg ctgaggcgcc acccttcttc aggcccaggc     6420

tccagaggaa gactcctgaa accctcccca ggtcttccaa gtacaggatt gaagctttag     6480

tgaaattaac caaggaccat gggtcagtgc ccagggcttt aaaaagaatg aacgagcaaa     6540

aggtatcccc gccgtgaccc ctgcagatag caccggtctt tgatccgcag caggggccag     6600

accctgccca caagtcccag cgcggctgct tctgccactg ctgggctcca cttggctcct     6660

ctcacttccc agggggtcgc ctgtcctgcc tgtgggtttc catggcttcc cagagctccc     6720

tctgccccag ccagcgcctc caggcccagc tgaggagctg tgagaagcag cagaggggac     6780

tccccatccc gggcacaccc tgtcctccca cccctgcccc cttgcccttc cagccctttc     6840

agctgcagct gggagctggc ccgtcaagtg ctgcccctgc ctgtgtctgg gtttctgttg     6900

gctgtttttc ttttcttgag tggtgatttt tctctaaata aaagaagtca agcactgaaa     6960

aaaaaaaaaa aaa                                                        6973


<210>  23
<211>  3318
<212>  DNA
<213>  homo sapiens

<400>  23
ctgccaggga agcggggctt cggctcggca ggctggacag tgcaggccaa ggtggagctg       60

tacctgtggc tgggcctcag caaacagcgc aaggagttcc tgtgcggcct gccctgtggc      120

ttccaggagg tcaaggcagc ccagggcctg ggcctgcatg ccttcccacc cgtcagcctg      180

gtctacacca agaagcaggc gttccagctc cgagcgcaca tgtaccaggc ccgcagcctc      240

tttgccgccg acagcagcgg actctcagac ccctttgccc gcgtcttctt catcaatcag      300

agtcagtgca cagaggtgct gaatgagacc ctgtgtccca cctgggacca gatgctggtg      360

ttcgacaacc tggagctcta tggtgaagct catgagctga gggacgatcc gcccatcatt      420

gtcattgaaa tctatgacca ggattccatg ggcaaagctg acttcatggg ccggaccttc      480

gccaaacccc tggtgaagat ggcagacgag gcgtactgcc caccccgctt cccacctcag      540

ctcgagtact accagatcta ccgtggcaac gccacagctg gagacctgct ggcggccttc      600

gagctgctgc agattggacc agcagggaag gctgacctgc cccccatcaa tggcccggtg      660

gacgtggacc gaggtcccat catgcccgtg cccatgggca tccggcccgt gctcagcaag      720

taccgagtgg aggtgctgtt ctggggccta cgggacctaa agcgggtgaa cctggcccag      780

gtggaccggc cacgggtgga catcgagtgt gcagggaagg gggtgcagtc gtccctgatc      840

cacaattata agaagaaccc caacttcaac accctcgtca agtggtttga agtggacctc      900

ccagagaacg agctgctgca cccgcccttg aacatccgtg tggtggactg ccgggccttc      960

ggtcgctaca cactggtggg ctcccatgcc gtcagctccc tgcgacgctt catctaccgg     1020

cccccagacc gctcggcccc cagctggaac accacggtca ggcttctccg gcgctgccgt     1080

gtgctgtgca atgggggctc ctcctctcac tccacagggg aggttgtggt gactatggag     1140

ccagaggtac ccatcaagaa actggagacc atggtgaagc tggacgcgac ttctgaagct     1200

gttgtcaagg tggatgtggc tgaggaggag aaggagaaga agaagaagaa gaagggcact     1260

gcggaggagc cagaggagga ggagccagac gagagcatgc tggactggtg gtccaagtac     1320

tttgcctcca ttgacaccat gaaggagcaa cttcgacaac aagagccctc tggaattgac     1380

ttggaggaga aggaggaagt ggacaatacc gagggcctga aggggtcaat gaagggcaag     1440

gagaaggcaa gggctgccaa agaggagaag aagaagaaaa ctcagagctc tggctctggc     1500

caggggtccg aggcccccga gaagaagaaa cccaagattg atgagcttaa ggtatacccc     1560

aaagagctgg agtccgagtt tgataacttt gaggactggc tgcacacttt caacttgctt     1620

cggggcaaga ccggggatga tgaggatggc tccaccgagg aggagcgcat tgtgggacgc     1680

ttcaagggct ccctctgcgt gtacaaagtg ccactcccag aggacgtgtc ccgggaagcc     1740

ggctacgact ccacctacgg catgttccag ggcatcccga gcaatgaccc catcaatgtg     1800

ctggtccgag tctatgtggt ccgggccacg gacctgcacc ctgctgacat caacggcaaa     1860

gctgacccct acatcgccat ccggctaggc aagactgaca tccgcgacaa ggagaactac     1920

atctccaagc agctcaaccc tgtctttggg aagtcctttg acatcgaggc ctccttcccc     1980

atggaatcca tgctgacggt ggctgtgtat gactgggacc tggtgggcac tgatgacctc     2040

attggggaaa ccaagatcga cctggagaac cgcttctaca gcaagcaccg cgccacctgc     2100

ggcatcgccc agacctactc cacacatggc tacaatatct ggcgggaccc catgaagccc     2160

agccagatcc tgacccgcct ctgcaaagac ggcaaagtgg acggccccca ctttgggccc     2220

cctgggagag tgaaggtggc caaccgcgtc ttcactgggc cctctgagat tgaggacgag     2280

aacggtcaga ggaagcccac agacgagcat gtggcgctgt tggccctgag gcactgggag     2340

gacatccccc gcgcaggctg ccgcctggtg ccagagcatg tggagacgag gccgctgctc     2400

aaccccgaca agccgggcat cgagcagggc cgcctggagc tgtgggtgga catgttcccc     2460

atggacatgc cagcccctgg gacgcctctg gacatctcac ctcggaagcc caagaagtac     2520

gagctgcggg tcatcatctg gaacacagat gaggtggtct tggaggacga cgacttcttc     2580

acaggggaga agtccagtga catcttcgtg agggggtggc tgaagggcca gcaggaggac     2640

aagcaggaca cagacgtcca ctaccactcc ctcactggcg agggcaactt caactggcgc     2700

tacctgttcc ccttcgacta cctggcggcg gaggagaaga tcgtcatctc caagaaggag     2760

tccatgttct cctgggacga gaccgagtac aagatccccg cgcggctcac cctgcagatc     2820

tgggatgcgg accacttctc cgctgacgac ttcctggggg ccatcgagct ggacctgaac     2880

cggttcccgc ggggcgcaaa gacagccaag cagtgcacca tggagatggc caccggggag     2940

gtggacgtgc ccctcgtgtc catcttcaag caaaagcgcg tcaaaggctg gtggcccctc     3000

ctggcccgca atgagaacga tgagtttgag ctcacgggca aggtggaggc tgagctgcat     3060

ttactgacag cagaggaggc agagaagaac ccagtgggcc tggcccgcaa tgaacctgac     3120

cccctagaga aacccaaccg gcccgacacg gccttcgtct ggttcctcaa ccctctcaag     3180

tccatcaagt acctcatctg cacccggtac aagtggctca tcatcaagat cgtgctggcg     3240

ctgttggggc tgctcatgtt ggggctcttc ctctacagcc tccctggcta catggtcaaa     3300

aagctccttg gggcatga                                                   3318


<210>  24
<211>  1260
<212>  PRT
<213>  homo sapiens

<400>  24

Met Met Thr Asp Thr Gln Asp Gly Pro Ser Glu Ser Ser Gln Ile Met 
1               5                   10                  15      


Arg Ser Leu Thr Pro Leu Ile Asn Arg Glu Glu Ala Phe Gly Glu Ala 
            20                  25                  30          


Gly Glu Ala Gly Leu Trp Pro Ser Ile Thr His Thr Pro Asp Ser Gln 
        35                  40                  45              


Glu Glu Gly Leu Asn Asp Ile Gln Glu Met Ile Lys Thr Glu Lys Ser 
    50                  55                  60                  


Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser Cys Gly 
65                  70                  75                  80  


Cys Cys Arg Phe Leu Ser Leu Ala Asp Lys Asp Gln Gly His Ser Ser 
                85                  90                  95      


Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg Glu Leu 
            100                 105                 110         


Glu Asn Met Gly Gln Gln Ala Arg Met Leu Arg Ala Gln Val Lys Arg 
        115                 120                 125             


His Thr Val Arg Asp Lys Leu Arg Leu Cys Gln Asn Phe Leu Gln Lys 
    130                 135                 140                 


Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp Ile Phe 
145                 150                 155                 160 


Ile Trp Met Met Ser Asn Asn Lys Arg Val Ala Tyr Ala Arg Val Pro 
                165                 170                 175     


Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Thr Gly Lys Asp 
            180                 185                 190         


Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys Arg Gly 
        195                 200                 205             


Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Val Glu Leu Tyr Leu 
    210                 215                 220                 


Trp Leu Gly Leu Ser Lys Gln Arg Lys Glu Phe Leu Cys Gly Leu Pro 
225                 230                 235                 240 


Cys Gly Phe Gln Glu Val Lys Ala Ala Gln Gly Leu Gly Leu His Ala 
                245                 250                 255     


Phe Pro Pro Val Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe Gln Leu 
            260                 265                 270         


Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp Ser Ser 
        275                 280                 285             


Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln Ser Gln 
    290                 295                 300                 


Cys Thr Glu Val Leu Asn Glu Thr Leu Cys Pro Thr Trp Asp Gln Met 
305                 310                 315                 320 


Leu Val Phe Asp Asn Leu Glu Leu Tyr Gly Glu Ala His Glu Leu Arg 
                325                 330                 335     


Asp Asp Pro Pro Ile Ile Val Ile Glu Ile Tyr Asp Gln Asp Ser Met 
            340                 345                 350         


Gly Lys Ala Asp Phe Met Gly Arg Thr Phe Ala Lys Pro Leu Val Lys 
        355                 360                 365             


Met Ala Asp Glu Ala Tyr Cys Pro Pro Arg Phe Pro Pro Gln Leu Glu 
    370                 375                 380                 


Tyr Tyr Gln Ile Tyr Arg Gly Asn Ala Thr Ala Gly Asp Leu Leu Ala 
385                 390                 395                 400 


Ala Phe Glu Leu Leu Gln Ile Gly Pro Ala Gly Lys Ala Asp Leu Pro 
                405                 410                 415     


Pro Ile Asn Gly Pro Val Asp Val Asp Arg Gly Pro Ile Met Pro Val 
            420                 425                 430         


Pro Met Gly Ile Arg Pro Val Leu Ser Lys Tyr Arg Val Glu Val Leu 
        435                 440                 445             


Phe Trp Gly Leu Arg Asp Leu Lys Arg Val Asn Leu Ala Gln Val Asp 
    450                 455                 460                 


Arg Pro Arg Val Asp Ile Glu Cys Ala Gly Lys Gly Val Gln Ser Ser 
465                 470                 475                 480 


Leu Ile His Asn Tyr Lys Lys Asn Pro Asn Phe Asn Thr Leu Val Lys 
                485                 490                 495     


Trp Phe Glu Val Asp Leu Pro Glu Asn Glu Leu Leu His Pro Pro Leu 
            500                 505                 510         


Asn Ile Arg Val Val Asp Cys Arg Ala Phe Gly Arg Tyr Thr Leu Val 
        515                 520                 525             


Gly Ser His Ala Val Ser Ser Leu Arg Arg Phe Ile Tyr Arg Pro Pro 
    530                 535                 540                 


Asp Arg Ser Ala Pro Ser Trp Asn Thr Thr Val Arg Leu Leu Arg Arg 
545                 550                 555                 560 


Cys Arg Val Leu Cys Asn Gly Gly Ser Ser Ser His Ser Thr Gly Glu 
                565                 570                 575     


Val Val Val Thr Met Glu Pro Glu Val Pro Ile Lys Lys Leu Glu Thr 
            580                 585                 590         


Met Val Lys Leu Asp Ala Thr Ser Glu Ala Val Val Lys Val Asp Val 
        595                 600                 605             


Ala Glu Glu Glu Lys Glu Lys Lys Lys Lys Lys Lys Gly Thr Ala Glu 
    610                 615                 620                 


Glu Pro Glu Glu Glu Glu Pro Asp Glu Ser Met Leu Asp Trp Trp Ser 
625                 630                 635                 640 


Lys Tyr Phe Ala Ser Ile Asp Thr Met Lys Glu Gln Leu Arg Gln Gln 
                645                 650                 655     


Glu Pro Ser Gly Ile Asp Leu Glu Glu Lys Glu Glu Val Asp Asn Thr 
            660                 665                 670         


Glu Gly Leu Lys Gly Ser Met Lys Gly Lys Glu Lys Ala Arg Ala Ala 
        675                 680                 685             


Lys Glu Glu Lys Lys Lys Lys Thr Gln Ser Ser Gly Ser Gly Gln Gly 
    690                 695                 700                 


Ser Glu Ala Pro Glu Lys Lys Lys Pro Lys Ile Asp Glu Leu Lys Val 
705                 710                 715                 720 


Tyr Pro Lys Glu Leu Glu Ser Glu Phe Asp Asn Phe Glu Asp Trp Leu 
                725                 730                 735     


His Thr Phe Asn Leu Leu Arg Gly Lys Thr Gly Asp Asp Glu Asp Gly 
            740                 745                 750         


Ser Thr Glu Glu Glu Arg Ile Val Gly Arg Phe Lys Gly Ser Leu Cys 
        755                 760                 765             


Val Tyr Lys Val Pro Leu Pro Glu Asp Val Ser Arg Glu Ala Gly Tyr 
    770                 775                 780                 


Asp Ser Thr Tyr Gly Met Phe Gln Gly Ile Pro Ser Asn Asp Pro Ile 
785                 790                 795                 800 


Asn Val Leu Val Arg Val Tyr Val Val Arg Ala Thr Asp Leu His Pro 
                805                 810                 815     


Ala Asp Ile Asn Gly Lys Ala Asp Pro Tyr Ile Ala Ile Arg Leu Gly 
            820                 825                 830         


Lys Thr Asp Ile Arg Asp Lys Glu Asn Tyr Ile Ser Lys Gln Leu Asn 
        835                 840                 845             


Pro Val Phe Gly Lys Ser Phe Asp Ile Glu Ala Ser Phe Pro Met Glu 
    850                 855                 860                 


Ser Met Leu Thr Val Ala Val Tyr Asp Trp Asp Leu Val Gly Thr Asp 
865                 870                 875                 880 


Asp Leu Ile Gly Glu Thr Lys Ile Asp Leu Glu Asn Arg Phe Tyr Ser 
                885                 890                 895     


Lys His Arg Ala Thr Cys Gly Ile Ala Gln Thr Tyr Ser Thr His Gly 
            900                 905                 910         


Tyr Asn Ile Trp Arg Asp Pro Met Lys Pro Ser Gln Ile Leu Thr Arg 
        915                 920                 925             


Leu Cys Lys Asp Gly Lys Val Asp Gly Pro His Phe Gly Pro Pro Gly 
    930                 935                 940                 


Arg Val Lys Val Ala Asn Arg Val Phe Thr Gly Pro Ser Glu Ile Glu 
945                 950                 955                 960 


Asp Glu Asn Gly Gln Arg Lys Pro Thr Asp Glu His Val Ala Leu Leu 
                965                 970                 975     


Ala Leu Arg His Trp Glu Asp Ile Pro Arg Ala Gly Cys Arg Leu Val 
            980                 985                 990         


Pro Glu His Val Glu Thr Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly 
        995                 1000                 1005             


Ile Glu  Gln Gly Arg Leu Glu  Leu Trp Val Asp Met  Phe Pro Met 
    1010                 1015                 1020             


Asp Met  Pro Ala Pro Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys 
    1025                 1030                 1035             


Pro Lys  Lys Tyr Glu Leu Arg  Val Ile Ile Trp Asn  Thr Asp Glu 
    1040                 1045                 1050             


Val Val  Leu Glu Asp Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser 
    1055                 1060                 1065             


Asp Ile  Phe Val Arg Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys 
    1070                 1075                 1080             


Gln Asp  Thr Asp Val His Tyr  His Ser Leu Thr Gly  Glu Gly Asn 
    1085                 1090                 1095             


Phe Asn  Trp Arg Tyr Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu 
    1100                 1105                 1110             


Glu Lys  Ile Val Ile Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp 
    1115                 1120                 1125             


Glu Thr  Glu Tyr Lys Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp 
    1130                 1135                 1140             


Asp Ala  Asp His Phe Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu 
    1145                 1150                 1155             


Leu Asp  Leu Asn Arg Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln 
    1160                 1165                 1170             


Cys Thr  Met Glu Met Ala Thr  Gly Glu Val Asp Val  Pro Leu Val 
    1175                 1180                 1185             


Ser Ile  Phe Lys Gln Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu 
    1190                 1195                 1200             


Ala Arg  Asn Glu Asn Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu 
    1205                 1210                 1215             


Ala Glu  Leu His Leu Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro 
    1220                 1225                 1230             


Val Gly  Leu Ala Arg Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn 
    1235                 1240                 1245             


Arg Pro  Asp Thr Ser Phe Ile  Trp Phe Leu Asn Pro  
    1250                 1255                 1260 


