                         SEQUENCE LISTING

<110>  INSERM
 
<120>  NEW VARIANTS OF ERYTHROFERRONE AND THEIR USE

<130>  BIO18095 FONTENAY

<160>  11    

<170>  PatentIn version 3.3

<210>  1
<211>  2939
<212>  DNA
<213>  Homo sapiens

<400>  1
gacgccgcgc tcggagccgc gagggaaccg ccgcccgcat ggccccggcc cgccgccccg     60

ccggagcccg cctgctgctc gtctacgcgg gcctgctggc cgccgccgcc gcgggcctgg    120

ggtccccgga gcctggggcg ccctcgagga gccgcgcccg cagggagccg ccgcccggga    180

acgagctgcc ccggggcccc ggggagagcc gcgcggggcc ggccgctcgt ccgccggagc    240

ccaccgctga gcgtgcacac agcgtcgacc cccgggacgc ctggatgctc ttcgtcaggc    300

agagtgacaa gggtgtcaat ggcaagaaga ggagcagggg caaggccaag aagctgaagt    360

tcggcttgcc agggccccct gggcctcccg gtccccaggg ccccccaggc cccatcatcc    420

cacccgaggc gctgctgaag gagttccagc tgctgctgaa aggtgcggtg cggcagcggg    480

agcgcgcgga gcccgaaccc tgtacgtgtg gccccgccgg gccggtcgct gcgagcctcg    540

ccccggtctc ggccaccgcc ggggaggacg acgacgacgt ggtgggggac gtgctggcac    600

tgctggccgc gcccctggcc ccggggccgc gggcgccgcg cgtggaggcc gctttcctct    660

gccgcctgcg ccgggacgcg ttggtggagc ggcgcgcgct gcacgagctt ggcgtctact    720

acctgcccga cgccgagggt gccttccgcc gcggcccggg cctgaacttg accagcggcc    780

agtacagggc gcccgtggct ggcttctacg ctctcgccgc cacgctgcac gtggcgctcg    840

gggagccgcc gaggaggggg ccgccgcgcc cccgggacca cctgcgcctg ctcatctgca    900

tccagtcccg gtgccagcgc aacgcctccc tggaggccat catgggcctg gagagcagca    960

gtgagctctt caccatctct gtgaatggcg tcctgtacct gcagatgggg cagtggacct   1020

ccgtgttctt ggacaacgcc agcggctgct ccctcacagt gcgcagtggc tcccacttca   1080

gtgctgtcct cctgggcgtg tgagcggcca ccacaggccc ttcctctcag gggcaaatgg   1140

agcacagatc tagacaatgt gtggacagtg tcagagtagc agtggccaca tggaggagga   1200

ggcccacccg gaactctgcc cacactggcc actgcagttc agcccacaga gccactgcag   1260

gcaggcctac ggacgtgaca cgcacgctgg tggtcccgga gccagggttg attcaggaca   1320

ccatcttggg ctcttatcca ggaaagaaag agtcggcgtg cctgggggca cctgctagtc   1380

tccagctgca ggccgactct ttcctggcct gctcagcacc tgcccagatg gcctctgcgt   1440

ctttcctgtg cccagcccca ccttttccac ctctcttcat gttctcatgg agtgcaaagt   1500

gcaccagcca gggcccctac ctgggagagg gtcagctgac gcagggctga gggggctgcc   1560

acagggacgt acgctgtgtg ttcttactgc ttagaaggga cggggtcact caccactccc   1620

ctggtctcca tctgggctcc ttggtcttcc ctgcccctcc cctaaccgtg ttctacctgc   1680

cagtggagct gagcactgcc tagcctgggc cagaggggca ctggacaagg gcctttgggg   1740

gacagtaagt ctgggcccag cttctagttc taatgtgtgc aagattaact cacaaattca   1800

cctcagaagg cctttccaaa tgggagctcc actcttcccc tcctctgcaa atcttcacag   1860

ccaaggcccc ttccaccctc tccagaggtg gatgagatcc cttttcccct cccctctgag   1920

gtgctgactc actggtagga gccacccacc agaggaaaga tctagaacgt ctttacagat   1980

tggagacagc cgggcctgct gacccatcat ccgaatagct gaagcagagt cttccaccag   2040

gggtgccagg gcctggctgg gtccagcggc tctgggatga gcctcccaag catctttccc   2100

acttgggtgg ccatgcggcg ctgacattgg acaggtggtg gacgagagat ggtcccgaga   2160

aagggtggtc ttgggagggc tggtcccaag cctgctgtgc tcctgtggca gtgatggggc   2220

ctggggatgg ggacggcagc tctcatgagg acacacaggc tgtgagcccg cagcctcctc   2280

aaatgtagcc tcccacattt tccccaaagt acaggactgt cccagagtag gtagtgaaga   2340

ggacaaggcc ctcggcagcg acctccaggg cctcctacct gctgaggaag agttaaccca   2400

ctgcctcccc acacaacagg ctacgaagaa cctggtgcct caggacctcc tgggagccaa   2460

gctggtctgg caagggcgct caggcctggg agagaaggga gcaatggcca gtcaccttca   2520

ccttctaact aactagcctc cggatgaggt ggctgccacc aggcccgaat gatccccagg   2580

agcccagctt ccaaacccca acatcgaatc aaacatctcc atccccaagt gcagtaacac   2640

acaaaaacca aacactctgc cctgggaaag gcctggtgcg attctcagta ggactcacac   2700

ccaccctacc tagaagtact gggctggcct gggtactgca tccgtgtgtt ttgataaggg   2760

ggtgatgtgg ccacgccctt atctagattt cactttgtat ccactgggca cagatattct   2820

agagaactta tctttcactc ttgtaaaagc cacatatcca catctctttc atttttctca   2880

gtgtgttatg cagcaattta ttaaagtatt tattgtctaa taaatactgc caagtggaa    2939


<210>  2
<211>  2951
<212>  DNA
<213>  Homo sapiens

<400>  2
gacgccgcgc tcggagccgc gagggaaccg ccgcccgcat ggccccggcc cgccgccccg     60

ccggagcccg cctgctgctc gtctacgcgg gcctgctggc cgccgccgcc gcgggcctgg    120

ggtccccgga gcctggggcg ccctcgagga gccgcgcccg cagggagccg ccgcccggga    180

acgagctgcc ccggggcccc ggggagagcc gcgcggggcc ggccgctcgt ccgccggagc    240

ccaccgctga gcgtgcacac agcgtcgacc cccgggacgc ctggatgctc ttcgtcaggc    300

agagtgacaa gggtgtcaat ggcaagaaga ggagcagggg caaggccaag aagctgaagg    360

ttccctttca gttcggcttg ccagggcccc ctgggcctcc cggtccccag ggccccccag    420

gccccatcat cccacccgag gcgctgctga aggagttcca gctgctgctg aaaggtgcgg    480

tgcggcagcg ggagcgcgcg gagcccgaac cctgtacgtg tggccccgcc gggccggtcg    540

ctgcgagcct cgccccggtc tcggccaccg ccggggagga cgacgacgac gtggtggggg    600

acgtgctggc actgctggcc gcgcccctgg ccccggggcc gcgggcgccg cgcgtggagg    660

ccgctttcct ctgccgcctg cgccgggacg cgttggtgga gcggcgcgcg ctgcacgagc    720

ttggcgtcta ctacctgccc gacgccgagg gtgccttccg ccgcggcccg ggcctgaact    780

tgaccagcgg ccagtacagg gcgcccgtgg ctggcttcta cgctctcgcc gccacgctgc    840

acgtggcgct cggggagccg ccgaggaggg ggccgccgcg cccccgggac cacctgcgcc    900

tgctcatctg catccagtcc cggtgccagc gcaacgcctc cctggaggcc atcatgggcc    960

tggagagcag cagtgagctc ttcaccatct ctgtgaatgg cgtcctgtac ctgcagatgg   1020

ggcagtggac ctccgtgttc ttggacaacg ccagcggctg ctccctcaca gtgcgcagtg   1080

gctcccactt cagtgctgtc ctcctgggcg tgtgagcggc caccacaggc ccttcctctc   1140

aggggcaaat ggagcacaga tctagacaat gtgtggacag tgtcagagta gcagtggcca   1200

catggaggag gaggcccacc cggaactctg cccacactgg ccactgcagt tcagcccaca   1260

gagccactgc aggcaggcct acggacgtga cacgcacgct ggtggtcccg gagccagggt   1320

tgattcagga caccatcttg ggctcttatc caggaaagaa agagtcggcg tgcctggggg   1380

cacctgctag tctccagctg caggccgact ctttcctggc ctgctcagca cctgcccaga   1440

tggcctctgc gtctttcctg tgcccagccc caccttttcc acctctcttc atgttctcat   1500

ggagtgcaaa gtgcaccagc cagggcccct acctgggaga gggtcagctg acgcagggct   1560

gagggggctg ccacagggac gtacgctgtg tgttcttact gcttagaagg gacggggtca   1620

ctcaccactc ccctggtctc catctgggct ccttggtctt ccctgcccct cccctaaccg   1680

tgttctacct gccagtggag ctgagcactg cctagcctgg gccagagggg cactggacaa   1740

gggcctttgg gggacagtaa gtctgggccc agcttctagt tctaatgtgt gcaagattaa   1800

ctcacaaatt cacctcagaa ggcctttcca aatgggagct ccactcttcc cctcctctgc   1860

aaatcttcac agccaaggcc ccttccaccc tctccagagg tggatgagat cccttttccc   1920

ctcccctctg aggtgctgac tcactggtag gagccaccca ccagaggaaa gatctagaac   1980

gtctttacag attggagaca gccgggcctg ctgacccatc atccgaatag ctgaagcaga   2040

gtcttccacc aggggtgcca gggcctggct gggtccagcg gctctgggat gagcctccca   2100

agcatctttc ccacttgggt ggccatgcgg cgctgacatt ggacaggtgg tggacgagag   2160

atggtcccga gaaagggtgg tcttgggagg gctggtccca agcctgctgt gctcctgtgg   2220

cagtgatggg gcctggggat ggggacggca gctctcatga ggacacacag gctgtgagcc   2280

cgcagcctcc tcaaatgtag cctcccacat tttccccaaa gtacaggact gtcccagagt   2340

aggtagtgaa gaggacaagg ccctcggcag cgacctccag ggcctcctac ctgctgagga   2400

agagttaacc cactgcctcc ccacacaaca ggctacgaag aacctggtgc ctcaggacct   2460

cctgggagcc aagctggtct ggcaagggcg ctcaggcctg ggagagaagg gagcaatggc   2520

cagtcacctt caccttctaa ctaactagcc tccggatgag gtggctgcca ccaggcccga   2580

atgatcccca ggagcccagc ttccaaaccc caacatcgaa tcaaacatct ccatccccaa   2640

gtgcagtaac acacaaaaac caaacactct gccctgggaa aggcctggtg cgattctcag   2700

taggactcac acccacccta cctagaagta ctgggctggc ctgggtactg catccgtgtg   2760

ttttgataag ggggtgatgt ggccacgccc ttatctagat ttcactttgt atccactggg   2820

cacagatatt ctagagaact tatctttcac tcttgtaaaa gccacatatc cacatctctt   2880

tcatttttct cagtgtgtta tgcagcaatt tattaaagta tttattgtct aataaatact   2940

gccaagtgga a                                                        2951


<210>  3
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Pro Ala Arg Arg Pro Ala Gly Ala Arg Leu Leu Leu Val Tyr 
1               5                   10                  15      


Ala Gly Leu Leu Ala Ala Ala Ala Ala Gly Leu Gly Ser Pro Glu Pro 
            20                  25                  30          


Gly Ala Pro Ser Arg Ser Arg Ala Arg Arg Glu Pro Pro Pro Gly Asn 
        35                  40                  45              


Glu Leu Pro Arg Gly Pro Gly Glu Ser Arg Ala Gly Pro Ala Ala Arg 
    50                  55                  60                  


Pro Pro Glu Pro Thr Ala Glu Arg Ala His Ser Val Asp Pro Arg Asp 
65                  70                  75                  80  


Ala Trp Met Leu Phe Val Arg Gln Ser Asp Lys Gly Val Asn Gly Lys 
                85                  90                  95      


Lys Arg Ser Arg Gly Lys Ala Lys Lys Leu Lys Phe Gly Leu Pro Gly 
            100                 105                 110         


Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Ile Ile Pro 
        115                 120                 125             


Pro Glu Ala Leu Leu Lys Glu Phe Gln Leu Leu Leu Lys Gly Ala Val 
    130                 135                 140                 


Arg Gln Arg Glu Arg Ala Glu Pro Glu Pro Cys Thr Cys Gly Pro Ala 
145                 150                 155                 160 


Gly Pro Val Ala Ala Ser Leu Ala Pro Val Ser Ala Thr Ala Gly Glu 
                165                 170                 175     


Asp Asp Asp Asp Val Val Gly Asp Val Leu Ala Leu Leu Ala Ala Pro 
            180                 185                 190         


Leu Ala Pro Gly Pro Arg Ala Pro Arg Val Glu Ala Ala Phe Leu Cys 
        195                 200                 205             


Arg Leu Arg Arg Asp Ala Leu Val Glu Arg Arg Ala Leu His Glu Leu 
    210                 215                 220                 


Gly Val Tyr Tyr Leu Pro Asp Ala Glu Gly Ala Phe Arg Arg Gly Pro 
225                 230                 235                 240 


Gly Leu Asn Leu Thr Ser Gly Gln Tyr Arg Ala Pro Val Ala Gly Phe 
                245                 250                 255     


Tyr Ala Leu Ala Ala Thr Leu His Val Ala Leu Gly Glu Pro Pro Arg 
            260                 265                 270         


Arg Gly Pro Pro Arg Pro Arg Asp His Leu Arg Leu Leu Ile Cys Ile 
        275                 280                 285             


Gln Ser Arg Cys Gln Arg Asn Ala Ser Leu Glu Ala Ile Met Gly Leu 
    290                 295                 300                 


Glu Ser Ser Ser Glu Leu Phe Thr Ile Ser Val Asn Gly Val Leu Tyr 
305                 310                 315                 320 


Leu Gln Met Gly Gln Trp Thr Ser Val Phe Leu Asp Asn Ala Ser Gly 
                325                 330                 335     


Cys Ser Leu Thr Val Arg Ser Gly Ser His Phe Ser Ala Val Leu Leu 
            340                 345                 350         


Gly Val 
        


<210>  4
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Pro Ala Arg Arg Pro Ala Gly Ala Arg Leu Leu Leu Val Tyr 
1               5                   10                  15      


Ala Gly Leu Leu Ala Ala Ala Ala Ala Gly Leu Gly Ser Pro Glu Pro 
            20                  25                  30          


Gly Ala Pro Ser Arg Ser Arg Ala Arg Arg Glu Pro Pro Pro Gly Asn 
        35                  40                  45              


Glu Leu Pro Arg Gly Pro Gly Glu Ser Arg Ala Gly Pro Ala Ala Arg 
    50                  55                  60                  


Pro Pro Glu Pro Thr Ala Glu Arg Ala His Ser Val Asp Pro Arg Asp 
65                  70                  75                  80  


Ala Trp Met Leu Phe Val Arg Gln Ser Asp Lys Gly Val Asn Gly Lys 
                85                  90                  95      


Lys Arg Ser Arg Gly Lys Ala Lys Lys Leu Lys Val Pro Phe Gln Phe 
            100                 105                 110         


Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly 
        115                 120                 125             


Pro Ile Ile Pro Pro Glu Ala Leu Leu Lys Glu Phe Gln Leu Leu Leu 
    130                 135                 140                 


Lys Gly Ala Val Arg Gln Arg Glu Arg Ala Glu Pro Glu Pro Cys Thr 
145                 150                 155                 160 


Cys Gly Pro Ala Gly Pro Val Ala Ala Ser Leu Ala Pro Val Ser Ala 
                165                 170                 175     


Thr Ala Gly Glu Asp Asp Asp Asp Val Val Gly Asp Val Leu Ala Leu 
            180                 185                 190         


Leu Ala Ala Pro Leu Ala Pro Gly Pro Arg Ala Pro Arg Val Glu Ala 
        195                 200                 205             


Ala Phe Leu Cys Arg Leu Arg Arg Asp Ala Leu Val Glu Arg Arg Ala 
    210                 215                 220                 


Leu His Glu Leu Gly Val Tyr Tyr Leu Pro Asp Ala Glu Gly Ala Phe 
225                 230                 235                 240 


Arg Arg Gly Pro Gly Leu Asn Leu Thr Ser Gly Gln Tyr Arg Ala Pro 
                245                 250                 255     


Val Ala Gly Phe Tyr Ala Leu Ala Ala Thr Leu His Val Ala Leu Gly 
            260                 265                 270         


Glu Pro Pro Arg Arg Gly Pro Pro Arg Pro Arg Asp His Leu Arg Leu 
        275                 280                 285             


Leu Ile Cys Ile Gln Ser Arg Cys Gln Arg Asn Ala Ser Leu Glu Ala 
    290                 295                 300                 


Ile Met Gly Leu Glu Ser Ser Ser Glu Leu Phe Thr Ile Ser Val Asn 
305                 310                 315                 320 


Gly Val Leu Tyr Leu Gln Met Gly Gln Trp Thr Ser Val Phe Leu Asp 
                325                 330                 335     


Asn Ala Ser Gly Cys Ser Leu Thr Val Arg Ser Gly Ser His Phe Ser 
            340                 345                 350         


Ala Val Leu Leu Gly Val 
        355             


<210>  5
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  4 amino acids VPFQ

<400>  5

Val Pro Phe Gln 
1               


<210>  6
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  12 nucleic acids GTTCCCTTTCAG

<400>  6
gttccctttc ag                                                         12


<210>  7
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  cryptic peptide

<400>  7

Val Pro Phe Gln Phe Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro 
1               5                   10                  15      


Gln Gly Pro Pro Gly Pro Ile Ile Pro Pro Glu Ala Leu Leu Lys 
            20                  25                  30      


<210>  8
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  ASO

<400>  8
aactgaaagg gaac                                                       14


<210>  9
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  ASO

<400>  9
aaagggaacc ttggcagtga ggaca                                           25


<210>  10
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ASO

<400>  10
accttggcag tgaggacatg t                                               21


<210>  11
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  peptide obtained by MS

<400>  11

Ala Leu His Glu Leu Gly Val Tyr Tyr Leu Pro Asp Ala Glu Gly Ala 
1               5                   10                  15      


Phe Arg 
        


