                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  E3 Ubiquitin ligase (UBE3A) protein targets

<130>  P35102-WO

<150>  EP19152337.2
<151>  2019-01-17

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  1871
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Asn Glu Ile Phe Thr Pro Leu Leu Glu Gln Phe Met Thr Ser 
1               5                   10                  15      


Pro Leu Val Thr Trp Val Lys Thr Phe Gly Pro Leu Ala Ala Gly Asn 
            20                  25                  30          


Gly Thr Asn Leu Asp Glu Tyr Val Ala Leu Val Asp Gly Val Phe Leu 
        35                  40                  45              


Asn Gln Val Met Leu Gln Ile Asn Pro Lys Leu Glu Ser Gln Arg Val 
    50                  55                  60                  


Asn Lys Lys Val Asn Asn Asp Ala Ser Leu Arg Met His Asn Leu Ser 
65                  70                  75                  80  


Ile Leu Val Arg Gln Ile Lys Phe Tyr Tyr Gln Glu Thr Leu Gln Gln 
                85                  90                  95      


Leu Ile Met Met Ser Leu Pro Asn Val Leu Ile Ile Gly Lys Asn Pro 
            100                 105                 110         


Phe Ser Glu Gln Gly Thr Glu Glu Val Lys Lys Leu Leu Leu Leu Leu 
        115                 120                 125             


Leu Gly Cys Ala Val Gln Cys Gln Lys Lys Glu Glu Phe Ile Glu Arg 
    130                 135                 140                 


Ile Gln Gly Leu Asp Phe Asp Thr Lys Ala Ala Val Ala Ala His Ile 
145                 150                 155                 160 


Gln Glu Val Thr His Asn Gln Glu Asn Val Phe Asp Leu Gln Trp Met 
                165                 170                 175     


Glu Val Thr Asp Met Ser Gln Glu Asp Ile Glu Pro Leu Leu Lys Asn 
            180                 185                 190         


Met Ala Leu His Leu Lys Arg Leu Ile Asp Glu Arg Asp Glu His Ser 
        195                 200                 205             


Glu Thr Ile Ile Glu Leu Ser Glu Glu Arg Asp Gly Leu His Phe Leu 
    210                 215                 220                 


Pro His Ala Ser Ser Ser Ala Gln Ser Pro Cys Gly Ser Pro Gly Met 
225                 230                 235                 240 


Lys Arg Thr Glu Ser Arg Gln His Leu Ser Val Glu Leu Ala Asp Ala 
                245                 250                 255     


Lys Ala Lys Ile Arg Arg Leu Arg Gln Glu Leu Glu Glu Lys Thr Glu 
            260                 265                 270         


Gln Leu Leu Asp Cys Lys Gln Glu Leu Glu Gln Met Glu Ile Glu Leu 
        275                 280                 285             


Lys Arg Leu Gln Gln Glu Asn Met Asn Leu Leu Ser Asp Ala Arg Ser 
    290                 295                 300                 


Ala Arg Met Tyr Arg Asp Glu Leu Asp Ala Leu Arg Glu Lys Ala Val 
305                 310                 315                 320 


Arg Val Asp Lys Leu Glu Ser Glu Val Ser Arg Tyr Lys Glu Arg Leu 
                325                 330                 335     


His Asp Ile Glu Phe Tyr Lys Ala Arg Val Glu Glu Leu Lys Glu Asp 
            340                 345                 350         


Asn Gln Val Leu Leu Glu Thr Lys Thr Met Leu Glu Asp Gln Leu Glu 
        355                 360                 365             


Gly Thr Arg Ala Arg Ser Asp Lys Leu His Glu Leu Glu Lys Glu Asn 
    370                 375                 380                 


Leu Gln Leu Lys Ala Lys Leu His Asp Met Glu Met Glu Arg Asp Met 
385                 390                 395                 400 


Asp Arg Lys Lys Ile Glu Glu Leu Met Glu Glu Asn Met Thr Leu Glu 
                405                 410                 415     


Met Ala Gln Lys Gln Ser Met Asp Glu Ser Leu His Leu Gly Trp Glu 
            420                 425                 430         


Leu Glu Gln Ile Ser Arg Thr Ser Glu Leu Ser Glu Ala Pro Gln Lys 
        435                 440                 445             


Ser Leu Gly His Glu Val Asn Glu Leu Thr Ser Ser Arg Leu Leu Lys 
    450                 455                 460                 


Leu Glu Met Glu Asn Gln Ser Leu Thr Lys Thr Val Glu Glu Leu Arg 
465                 470                 475                 480 


Thr Thr Val Asp Ser Val Glu Gly Asn Ala Ser Lys Ile Leu Lys Met 
                485                 490                 495     


Glu Lys Glu Asn Gln Arg Leu Ser Lys Lys Val Glu Ile Leu Glu Asn 
            500                 505                 510         


Glu Ile Val Gln Glu Lys Gln Ser Leu Gln Asn Cys Gln Asn Leu Ser 
        515                 520                 525             


Lys Asp Leu Met Lys Glu Lys Ala Gln Leu Glu Lys Thr Ile Glu Thr 
    530                 535                 540                 


Leu Arg Glu Asn Ser Glu Arg Gln Ile Lys Ile Leu Glu Gln Glu Asn 
545                 550                 555                 560 


Glu His Leu Asn Gln Thr Val Ser Ser Leu Arg Gln Arg Ser Gln Ile 
                565                 570                 575     


Ser Ala Glu Ala Arg Val Lys Asp Ile Glu Lys Glu Asn Lys Ile Leu 
            580                 585                 590         


His Glu Ser Ile Lys Glu Thr Ser Ser Lys Leu Ser Lys Ile Glu Phe 
        595                 600                 605             


Glu Lys Arg Gln Ile Lys Lys Glu Leu Glu His Tyr Lys Glu Lys Gly 
    610                 615                 620                 


Glu Arg Ala Glu Glu Leu Glu Asn Glu Leu His His Leu Glu Lys Glu 
625                 630                 635                 640 


Asn Glu Leu Leu Gln Lys Lys Ile Thr Asn Leu Lys Ile Thr Cys Glu 
                645                 650                 655     


Lys Ile Glu Ala Leu Glu Gln Glu Asn Ser Glu Leu Glu Arg Glu Asn 
            660                 665                 670         


Arg Lys Leu Lys Lys Thr Leu Asp Ser Phe Lys Asn Leu Thr Phe Gln 
        675                 680                 685             


Leu Glu Ser Leu Glu Lys Glu Asn Ser Gln Leu Asp Glu Glu Asn Leu 
    690                 695                 700                 


Glu Leu Arg Arg Asn Val Glu Ser Leu Lys Cys Ala Ser Met Lys Met 
705                 710                 715                 720 


Ala Gln Leu Gln Leu Glu Asn Lys Glu Leu Glu Ser Glu Lys Glu Gln 
                725                 730                 735     


Leu Lys Lys Gly Leu Glu Leu Leu Lys Ala Ser Phe Lys Lys Thr Glu 
            740                 745                 750         


Arg Leu Glu Val Ser Tyr Gln Gly Leu Asp Ile Glu Asn Gln Arg Leu 
        755                 760                 765             


Gln Lys Thr Leu Glu Asn Ser Asn Lys Lys Ile Gln Gln Leu Glu Ser 
    770                 775                 780                 


Glu Leu Gln Asp Leu Glu Met Glu Asn Gln Thr Leu Gln Lys Asn Leu 
785                 790                 795                 800 


Glu Glu Leu Lys Ile Ser Ser Lys Arg Leu Glu Gln Leu Glu Lys Glu 
                805                 810                 815     


Asn Lys Ser Leu Glu Gln Glu Thr Ser Gln Leu Glu Lys Asp Lys Lys 
            820                 825                 830         


Gln Leu Glu Lys Glu Asn Lys Arg Leu Arg Gln Gln Ala Glu Ile Lys 
        835                 840                 845             


Asp Thr Thr Leu Glu Glu Asn Asn Val Lys Ile Gly Asn Leu Glu Lys 
    850                 855                 860                 


Glu Asn Lys Thr Leu Ser Lys Glu Ile Gly Ile Tyr Lys Glu Ser Cys 
865                 870                 875                 880 


Val Arg Leu Lys Glu Leu Glu Lys Glu Asn Lys Glu Leu Val Lys Arg 
                885                 890                 895     


Ala Thr Ile Asp Ile Lys Thr Leu Val Thr Leu Arg Glu Asp Leu Val 
            900                 905                 910         


Ser Glu Lys Leu Lys Thr Gln Gln Met Asn Asn Asp Leu Glu Lys Leu 
        915                 920                 925             


Thr His Glu Leu Glu Lys Ile Gly Leu Asn Lys Glu Arg Leu Leu His 
    930                 935                 940                 


Asp Glu Gln Ser Thr Asp Asp Ser Arg Tyr Lys Leu Leu Glu Ser Lys 
945                 950                 955                 960 


Leu Glu Ser Thr Leu Lys Lys Ser Leu Glu Ile Lys Glu Glu Lys Ile 
                965                 970                 975     


Ala Ala Leu Glu Ala Arg Leu Glu Glu Ser Thr Asn Tyr Asn Gln Gln 
            980                 985                 990         


Leu Arg Gln Glu Leu Lys Thr Val  Lys Lys Asn Tyr Glu  Ala Leu Lys 
        995                 1000                 1005             


Gln Arg  Gln Asp Glu Glu Arg  Met Val Gln Ser Ser  Pro Pro Ile 
    1010                 1015                 1020             


Ser Gly  Glu Asp Asn Lys Trp  Glu Arg Glu Ser Gln  Glu Thr Thr 
    1025                 1030                 1035             


Arg Glu  Leu Leu Lys Val Lys  Asp Arg Leu Ile Glu  Val Glu Arg 
    1040                 1045                 1050             


Asn Asn  Ala Thr Leu Gln Ala  Glu Lys Gln Ala Leu  Lys Thr Gln 
    1055                 1060                 1065             


Leu Lys  Gln Leu Glu Thr Gln  Asn Asn Asn Leu Gln  Ala Gln Ile 
    1070                 1075                 1080             


Leu Ala  Leu Gln Arg Gln Thr  Val Ser Leu Gln Glu  Gln Asn Thr 
    1085                 1090                 1095             


Thr Leu  Gln Thr Gln Asn Ala  Lys Leu Gln Val Glu  Asn Ser Thr 
    1100                 1105                 1110             


Leu Asn  Ser Gln Ser Thr Ser  Leu Met Asn Gln Asn  Ala Gln Leu 
    1115                 1120                 1125             


Leu Ile  Gln Gln Ser Ser Leu  Glu Asn Glu Asn Glu  Ser Val Ile 
    1130                 1135                 1140             


Lys Glu  Arg Glu Asp Leu Lys  Ser Leu Tyr Asp Ser  Leu Ile Lys 
    1145                 1150                 1155             


Asp His  Glu Lys Leu Glu Leu  Leu His Glu Arg Gln  Ala Ser Glu 
    1160                 1165                 1170             


Tyr Glu  Ser Leu Ile Ser Lys  His Gly Thr Leu Lys  Ser Ala His 
    1175                 1180                 1185             


Lys Asn  Leu Glu Val Glu His  Arg Asp Leu Glu Asp  Arg Tyr Asn 
    1190                 1195                 1200             


Gln Leu  Leu Lys Gln Lys Gly  Gln Leu Glu Asp Leu  Glu Lys Met 
    1205                 1210                 1215             


Leu Lys  Val Glu Gln Glu Lys  Met Leu Leu Glu Asn  Lys Asn His 
    1220                 1225                 1230             


Glu Thr  Val Ala Ala Glu Tyr  Lys Lys Leu Cys Gly  Glu Asn Asp 
    1235                 1240                 1245             


Arg Leu  Asn His Thr Tyr Ser  Gln Leu Leu Lys Glu  Thr Glu Val 
    1250                 1255                 1260             


Leu Gln  Thr Asp His Lys Asn  Leu Lys Ser Leu Leu  Asn Asn Ser 
    1265                 1270                 1275             


Lys Leu  Glu Gln Thr Arg Leu  Glu Ala Glu Phe Ser  Lys Leu Lys 
    1280                 1285                 1290             


Glu Gln  Tyr Gln Gln Leu Asp  Ile Thr Ser Thr Lys  Leu Asn Asn 
    1295                 1300                 1305             


Gln Cys  Glu Leu Leu Ser Gln  Leu Lys Gly Asn Leu  Glu Glu Glu 
    1310                 1315                 1320             


Asn Arg  His Leu Leu Asp Gln  Ile Gln Thr Leu Met  Leu Gln Asn 
    1325                 1330                 1335             


Arg Thr  Leu Leu Glu Gln Asn  Met Glu Ser Lys Asp  Leu Phe His 
    1340                 1345                 1350             


Val Glu  Gln Arg Gln Tyr Ile  Asp Lys Leu Asn Glu  Leu Arg Arg 
    1355                 1360                 1365             


Gln Lys  Glu Lys Leu Glu Glu  Lys Ile Met Asp Gln  Tyr Lys Phe 
    1370                 1375                 1380             


Tyr Asp  Pro Ser Pro Pro Arg  Arg Arg Gly Asn Trp  Ile Thr Leu 
    1385                 1390                 1395             


Lys Met  Arg Lys Leu Ile Lys  Ser Lys Lys Asp Ile  Asn Arg Glu 
    1400                 1405                 1410             


Arg Gln  Lys Ser Leu Thr Leu  Thr Pro Thr Arg Ser  Asp Ser Ser 
    1415                 1420                 1425             


Glu Gly  Phe Leu Gln Leu Pro  His Gln Asp Ser Gln  Asp Ser Ser 
    1430                 1435                 1440             


Ser Val  Gly Ser Asn Ser Leu  Glu Asp Gly Gln Thr  Leu Gly Thr 
    1445                 1450                 1455             


Lys Lys  Ser Ser Met Val Ala  Leu Lys Arg Leu Pro  Phe Leu Arg 
    1460                 1465                 1470             


Asn Arg  Pro Lys Asp Lys Asp  Lys Met Lys Ala Cys  Tyr Arg Arg 
    1475                 1480                 1485             


Ser Met  Ser Met Asn Asp Leu  Val Gln Ser Met Val  Leu Ala Gly 
    1490                 1495                 1500             


Gln Trp  Thr Gly Ser Thr Glu  Asn Leu Glu Val Pro  Asp Asp Ile 
    1505                 1510                 1515             


Ser Thr  Gly Lys Arg Arg Lys  Glu Leu Gly Ala Met  Ala Phe Ser 
    1520                 1525                 1530             


Thr Thr  Ala Ile Asn Phe Ser  Thr Val Asn Ser Ser  Ala Gly Phe 
    1535                 1540                 1545             


Arg Ser  Lys Gln Leu Val Asn  Asn Lys Asp Thr Thr  Ser Phe Glu 
    1550                 1555                 1560             


Asp Ile  Ser Pro Gln Gly Val  Ser Asp Asp Ser Ser  Thr Gly Ser 
    1565                 1570                 1575             


Arg Val  His Ala Ser Arg Pro  Ala Ser Leu Asp Ser  Gly Arg Thr 
    1580                 1585                 1590             


Ser Thr  Ser Asn Ser Asn Asn  Asn Ala Ser Leu His  Glu Val Lys 
    1595                 1600                 1605             


Ala Gly  Ala Val Asn Asn Gln  Ser Arg Pro Gln Ser  His Ser Ser 
    1610                 1615                 1620             


Gly Glu  Phe Ser Leu Leu His  Asp His Glu Ala Trp  Ser Ser Ser 
    1625                 1630                 1635             


Gly Ser  Ser Pro Ile Gln Tyr  Leu Lys Arg Gln Thr  Arg Ser Ser 
    1640                 1645                 1650             


Pro Val  Leu Gln His Lys Ile  Ser Glu Thr Leu Glu  Ser Arg His 
    1655                 1660                 1665             


His Lys  Ile Lys Thr Gly Ser  Pro Gly Ser Glu Val  Val Thr Leu 
    1670                 1675                 1680             


Gln Gln  Phe Leu Glu Glu Ser  Asn Lys Leu Thr Ser  Val Gln Ile 
    1685                 1690                 1695             


Lys Ser  Ser Ser Gln Glu Asn  Leu Leu Asp Glu Val  Met Lys Ser 
    1700                 1705                 1710             


Leu Ser  Val Ser Ser Asp Phe  Leu Gly Lys Asp Lys  Pro Val Ser 
    1715                 1720                 1725             


Cys Gly  Leu Ala Arg Ser Val  Ser Gly Lys Thr Pro  Gly Asp Phe 
    1730                 1735                 1740             


Tyr Asp  Arg Arg Thr Thr Lys  Pro Glu Phe Leu Arg  Pro Gly Pro 
    1745                 1750                 1755             


Arg Lys  Thr Glu Asp Thr Tyr  Phe Ile Ser Ser Ala  Gly Lys Pro 
    1760                 1765                 1770             


Thr Pro  Gly Thr Gln Gly Lys  Ile Lys Leu Val Lys  Glu Ser Ser 
    1775                 1780                 1785             


Leu Ser  Arg Gln Ser Lys Asp  Ser Asn Pro Tyr Ala  Thr Leu Pro 
    1790                 1795                 1800             


Arg Ala  Ser Ser Val Ile Ser  Thr Ala Glu Gly Thr  Thr Arg Arg 
    1805                 1810                 1815             


Thr Ser  Ile His Asp Phe Leu  Thr Lys Asp Ser Arg  Leu Pro Ile 
    1820                 1825                 1830             


Ser Val  Asp Ser Pro Pro Ala  Ala Ala Asp Ser Asn  Thr Thr Ala 
    1835                 1840                 1845             


Ala Ser  Asn Val Asp Lys Val  Gln Glu Ser Arg Asn  Ser Lys Ser 
    1850                 1855                 1860             


Arg Ser  Arg Glu Gln Gln Ser  Ser 
    1865                 1870     


<210>  2
<211>  7570
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gly Tyr Leu Ser Pro Ala Ala Tyr Leu Tyr Val Glu Glu Gln 
1               5                   10                  15      


Glu Tyr Leu Gln Ala Tyr Glu Asp Val Leu Glu Arg Tyr Lys Asp Glu 
            20                  25                  30          


Arg Asp Lys Val Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Gln His 
        35                  40                  45              


Leu Met Lys Val Arg Lys His Val Asn Asp Leu Tyr Glu Asp Leu Arg 
    50                  55                  60                  


Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp Thr 
65                  70                  75                  80  


Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Arg Leu Gln Asn Val 
                85                  90                  95      


Gln Ile Ala Leu Asp Tyr Leu Lys Arg Arg Gln Val Lys Leu Val Asn 
            100                 105                 110         


Ile Arg Asn Asp Asp Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly 
        115                 120                 125             


Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile His Val 
    130                 135                 140                 


Thr Gly Glu Ser Glu Asp Met Ser Ala Lys Glu Arg Leu Leu Leu Trp 
145                 150                 155                 160 


Thr Gln Gln Ala Thr Glu Gly Tyr Ala Gly Ile Arg Cys Glu Asn Phe 
                165                 170                 175     


Thr Thr Cys Trp Arg Asp Gly Lys Leu Phe Asn Ala Ile Ile His Lys 
            180                 185                 190         


Tyr Arg Pro Asp Leu Ile Asp Met Asn Thr Val Ala Val Gln Ser Asn 
        195                 200                 205             


Leu Ala Asn Leu Glu His Ala Phe Tyr Val Ala Glu Lys Ile Gly Val 
    210                 215                 220                 


Ile Arg Leu Leu Asp Pro Glu Asp Val Asp Val Ser Ser Pro Asp Glu 
225                 230                 235                 240 


Lys Ser Val Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Phe Pro Lys 
                245                 250                 255     


Val Pro Glu Gly Gly Glu Gly Ile Gly Ala Asn Asp Val Glu Val Lys 
            260                 265                 270         


Trp Ile Glu Tyr Gln Asn Met Val Asn Tyr Leu Ile Gln Trp Ile Arg 
        275                 280                 285             


His His Val Thr Thr Met Ser Glu Arg Thr Phe Pro Asn Asn Pro Val 
    290                 295                 300                 


Glu Leu Lys Ala Leu Tyr Asn Gln Tyr Leu Gln Phe Lys Glu Thr Glu 
305                 310                 315                 320 


Ile Pro Pro Lys Glu Thr Glu Lys Ser Lys Ile Lys Arg Leu Tyr Lys 
                325                 330                 335     


Leu Leu Glu Ile Trp Ile Glu Phe Gly Arg Ile Lys Leu Leu Gln Gly 
            340                 345                 350         


Tyr His Pro Asn Asp Ile Glu Lys Glu Trp Gly Lys Leu Ile Ile Ala 
        355                 360                 365             


Met Leu Glu Arg Glu Lys Ala Leu Arg Pro Glu Val Glu Arg Leu Glu 
    370                 375                 380                 


Met Leu Gln Gln Ile Ala Asn Arg Val Gln Arg Asp Ser Val Ile Cys 
385                 390                 395                 400 


Glu Asp Lys Leu Ile Leu Ala Gly Asn Ala Leu Gln Ser Asp Ser Lys 
                405                 410                 415     


Arg Leu Glu Ser Gly Val Gln Phe Gln Asn Glu Ala Glu Ile Ala Gly 
            420                 425                 430         


Tyr Ile Leu Glu Cys Glu Asn Leu Leu Arg Gln His Val Ile Asp Val 
        435                 440                 445             


Gln Ile Leu Ile Asp Gly Lys Tyr Tyr Gln Ala Asp Gln Leu Val Gln 
    450                 455                 460                 


Arg Val Ala Lys Leu Arg Asp Glu Ile Met Ala Leu Arg Asn Glu Cys 
465                 470                 475                 480 


Ser Ser Val Tyr Ser Lys Gly Arg Ile Leu Thr Thr Glu Gln Thr Lys 
                485                 490                 495     


Leu Met Ile Ser Gly Ile Thr Gln Ser Leu Asn Ser Gly Phe Ala Gln 
            500                 505                 510         


Thr Leu His Pro Ser Leu Thr Ser Gly Leu Thr Gln Ser Leu Thr Pro 
        515                 520                 525             


Ser Leu Thr Ser Ser Ser Met Thr Ser Gly Leu Ser Ser Gly Met Thr 
    530                 535                 540                 


Ser Arg Leu Thr Pro Ser Val Thr Pro Ala Tyr Thr Pro Gly Phe Pro 
545                 550                 555                 560 


Ser Gly Leu Val Pro Asn Phe Ser Ser Gly Val Glu Pro Asn Ser Leu 
                565                 570                 575     


Gln Thr Leu Lys Leu Met Gln Ile Arg Lys Pro Leu Leu Lys Ser Ser 
            580                 585                 590         


Leu Leu Asp Gln Asn Leu Thr Glu Glu Glu Ile Asn Met Lys Phe Val 
        595                 600                 605             


Gln Asp Leu Leu Asn Trp Val Asp Glu Met Gln Val Gln Leu Asp Arg 
    610                 615                 620                 


Thr Glu Trp Gly Ser Asp Leu Pro Ser Val Glu Ser His Leu Glu Asn 
625                 630                 635                 640 


His Lys Asn Val His Arg Ala Ile Glu Glu Phe Glu Ser Ser Leu Lys 
                645                 650                 655     


Glu Ala Lys Ile Ser Glu Ile Gln Met Thr Ala Pro Leu Lys Leu Thr 
            660                 665                 670         


Tyr Ala Glu Lys Leu His Arg Leu Glu Ser Gln Tyr Ala Lys Leu Leu 
        675                 680                 685             


Asn Thr Ser Arg Asn Gln Glu Arg His Leu Asp Thr Leu His Asn Phe 
    690                 695                 700                 


Val Ser Arg Ala Thr Asn Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu 
705                 710                 715                 720 


Glu Glu Val Ala Tyr Asp Trp Ser Glu Arg Asn Thr Asn Ile Ala Arg 
                725                 730                 735     


Lys Lys Asp Tyr His Ala Glu Leu Met Arg Glu Leu Asp Gln Lys Glu 
            740                 745                 750         


Glu Asn Ile Lys Ser Val Gln Glu Ile Ala Glu Gln Leu Leu Leu Glu 
        755                 760                 765             


Asn His Pro Ala Arg Leu Thr Ile Glu Ala Tyr Arg Ala Ala Met Gln 
    770                 775                 780                 


Thr Gln Trp Ser Trp Ile Leu Gln Leu Cys Gln Cys Val Glu Gln His 
785                 790                 795                 800 


Ile Lys Glu Asn Thr Ala Tyr Phe Glu Phe Phe Asn Asp Ala Lys Glu 
                805                 810                 815     


Ala Thr Asp Tyr Leu Arg Asn Leu Lys Asp Ala Ile Gln Arg Lys Tyr 
            820                 825                 830         


Ser Cys Asp Arg Ser Ser Ser Ile His Lys Leu Glu Asp Leu Val Gln 
        835                 840                 845             


Glu Ser Met Glu Glu Lys Glu Glu Leu Leu Gln Tyr Lys Ser Thr Ile 
    850                 855                 860                 


Ala Asn Leu Met Gly Lys Ala Lys Thr Ile Ile Gln Leu Lys Pro Arg 
865                 870                 875                 880 


Asn Ser Asp Cys Pro Leu Lys Thr Ser Ile Pro Ile Lys Ala Ile Cys 
                885                 890                 895     


Asp Tyr Arg Gln Ile Glu Ile Thr Ile Tyr Lys Asp Asp Glu Cys Val 
            900                 905                 910         


Leu Ala Asn Asn Ser His Arg Ala Lys Trp Lys Val Ile Ser Pro Thr 
        915                 920                 925             


Gly Asn Glu Ala Met Val Pro Ser Val Cys Phe Thr Val Pro Pro Pro 
    930                 935                 940                 


Asn Lys Glu Ala Val Asp Leu Ala Asn Arg Ile Glu Gln Gln Tyr Gln 
945                 950                 955                 960 


Asn Val Leu Thr Leu Trp His Glu Ser His Ile Asn Met Lys Ser Val 
                965                 970                 975     


Val Ser Trp His Tyr Leu Ile Asn Glu Ile Asp Arg Ile Arg Ala Ser 
            980                 985                 990         


Asn Val Ala Ser Ile Lys Thr Met  Leu Pro Gly Glu His  Gln Gln Val 
        995                 1000                 1005             


Leu Ser  Asn Leu Gln Ser Arg  Phe Glu Asp Phe Leu  Glu Asp Ser 
    1010                 1015                 1020             


Gln Glu  Ser Gln Val Phe Ser  Gly Ser Asp Ile Thr  Gln Leu Glu 
    1025                 1030                 1035             


Lys Glu  Val Asn Val Cys Lys  Gln Tyr Tyr Gln Glu  Leu Leu Lys 
    1040                 1045                 1050             


Ser Ala  Glu Arg Glu Glu Gln  Glu Glu Ser Val Tyr  Asn Leu Tyr 
    1055                 1060                 1065             


Ile Ser  Glu Val Arg Asn Ile  Arg Leu Arg Leu Glu  Asn Cys Glu 
    1070                 1075                 1080             


Asp Arg  Leu Ile Arg Gln Ile  Arg Thr Pro Leu Glu  Arg Asp Asp 
    1085                 1090                 1095             


Leu His  Glu Ser Val Phe Arg  Ile Thr Glu Gln Glu  Lys Leu Lys 
    1100                 1105                 1110             


Lys Glu  Leu Glu Arg Leu Lys  Asp Asp Leu Gly Thr  Ile Thr Asn 
    1115                 1120                 1125             


Lys Cys  Glu Glu Phe Phe Ser  Gln Ala Ala Ala Ser  Ser Ser Val 
    1130                 1135                 1140             


Pro Thr  Leu Arg Ser Glu Leu  Asn Val Val Leu Gln  Asn Met Asn 
    1145                 1150                 1155             


Gln Val  Tyr Ser Met Ser Ser  Thr Tyr Ile Asp Lys  Leu Lys Thr 
    1160                 1165                 1170             


Val Asn  Leu Val Leu Lys Asn  Thr Gln Ala Ala Glu  Ala Leu Val 
    1175                 1180                 1185             


Lys Leu  Tyr Glu Thr Lys Leu  Cys Glu Glu Glu Ala  Val Ile Ala 
    1190                 1195                 1200             


Asp Lys  Asn Asn Ile Glu Asn  Leu Ile Ser Thr Leu  Lys Gln Trp 
    1205                 1210                 1215             


Arg Ser  Glu Val Asp Glu Lys  Arg Gln Val Phe His  Ala Leu Glu 
    1220                 1225                 1230             


Asp Glu  Leu Gln Lys Ala Lys  Ala Ile Ser Asp Glu  Met Phe Lys 
    1235                 1240                 1245             


Thr Tyr  Lys Glu Arg Asp Leu  Asp Phe Asp Trp His  Lys Glu Lys 
    1250                 1255                 1260             


Ala Asp  Gln Leu Val Glu Arg  Trp Gln Asn Val His  Val Gln Ile 
    1265                 1270                 1275             


Asp Asn  Arg Leu Arg Asp Leu  Glu Gly Ile Gly Lys  Ser Leu Lys 
    1280                 1285                 1290             


Tyr Tyr  Arg Asp Thr Tyr His  Pro Leu Asp Asp Trp  Ile Gln Gln 
    1295                 1300                 1305             


Val Glu  Thr Thr Gln Arg Lys  Ile Gln Glu Asn Gln  Pro Glu Asn 
    1310                 1315                 1320             


Ser Lys  Thr Leu Ala Thr Gln  Leu Asn Gln Gln Lys  Met Leu Val 
    1325                 1330                 1335             


Ser Glu  Ile Glu Met Lys Gln  Ser Lys Met Asp Glu  Cys Gln Lys 
    1340                 1345                 1350             


Tyr Ala  Glu Gln Tyr Ser Ala  Thr Val Lys Asp Tyr  Glu Leu Gln 
    1355                 1360                 1365             


Thr Met  Thr Tyr Arg Ala Met  Val Asp Ser Gln Gln  Lys Ser Pro 
    1370                 1375                 1380             


Val Lys  Arg Arg Arg Met Gln  Ser Ser Ala Asp Leu  Ile Ile Gln 
    1385                 1390                 1395             


Glu Phe  Met Asp Leu Arg Thr  Arg Tyr Thr Ala Leu  Val Thr Leu 
    1400                 1405                 1410             


Met Thr  Gln Tyr Ile Lys Phe  Ala Gly Asp Ser Leu  Lys Arg Leu 
    1415                 1420                 1425             


Glu Glu  Glu Glu Lys Ser Leu  Glu Glu Glu Lys Lys  Glu His Val 
    1430                 1435                 1440             


Glu Lys  Ala Lys Glu Leu Gln  Lys Trp Val Ser Asn  Ile Ser Lys 
    1445                 1450                 1455             


Thr Leu  Lys Asp Ala Glu Lys  Ala Gly Lys Pro Pro  Phe Ser Lys 
    1460                 1465                 1470             


Gln Lys  Ile Ser Ser Glu Glu  Ile Ser Thr Lys Lys  Glu Gln Leu 
    1475                 1480                 1485             


Ser Glu  Ala Leu Gln Thr Ile  Gln Leu Phe Leu Ala  Lys His Gly 
    1490                 1495                 1500             


Asp Lys  Met Thr Asp Glu Glu  Arg Asn Glu Leu Glu  Lys Gln Val 
    1505                 1510                 1515             


Lys Thr  Leu Gln Glu Ser Tyr  Asn Leu Leu Phe Ser  Glu Ser Leu 
    1520                 1525                 1530             


Lys Gln  Leu Gln Glu Ser Gln  Thr Ser Gly Asp Val  Lys Val Glu 
    1535                 1540                 1545             


Glu Lys  Leu Asp Lys Val Ile  Ala Gly Thr Ile Asp  Gln Thr Thr 
    1550                 1555                 1560             


Gly Glu  Val Leu Ser Val Phe  Gln Ala Val Leu Arg  Gly Leu Ile 
    1565                 1570                 1575             


Asp Tyr  Asp Thr Gly Ile Arg  Leu Leu Glu Thr Gln  Leu Met Ile 
    1580                 1585                 1590             


Ser Gly  Leu Ile Ser Pro Glu  Leu Arg Lys Cys Phe  Asp Leu Lys 
    1595                 1600                 1605             


Asp Ala  Lys Ser His Gly Leu  Ile Asp Glu Gln Ile  Leu Cys Gln 
    1610                 1615                 1620             


Leu Lys  Glu Leu Ser Lys Ala  Lys Glu Ile Ile Ser  Ala Ala Ser 
    1625                 1630                 1635             


Pro Thr  Thr Ile Pro Val Leu  Asp Ala Leu Ala Gln  Ser Met Ile 
    1640                 1645                 1650             


Thr Glu  Ser Met Ala Ile Lys  Val Leu Glu Ile Leu  Leu Ser Thr 
    1655                 1660                 1665             


Gly Ser  Leu Val Ile Pro Ala  Thr Gly Glu Gln Leu  Thr Leu Gln 
    1670                 1675                 1680             


Lys Ala  Phe Gln Gln Asn Leu  Val Ser Ser Ala Leu  Phe Ser Lys 
    1685                 1690                 1695             


Val Leu  Glu Arg Gln Asn Met  Cys Lys Asp Leu Ile  Asp Pro Cys 
    1700                 1705                 1710             


Thr Ser  Glu Lys Val Ser Leu  Ile Asp Met Val Gln  Arg Ser Thr 
    1715                 1720                 1725             


Leu Gln  Glu Asn Thr Gly Met  Trp Leu Leu Pro Val  Arg Pro Gln 
    1730                 1735                 1740             


Glu Gly  Gly Arg Ile Thr Leu  Lys Cys Gly Arg Asn  Ile Ser Ile 
    1745                 1750                 1755             


Leu Arg  Ala Ala His Glu Gly  Leu Ile Asp Arg Glu  Thr Met Phe 
    1760                 1765                 1770             


Arg Leu  Leu Ser Ala Gln Leu  Leu Ser Gly Gly Leu  Ile Asn Ser 
    1775                 1780                 1785             


Asn Ser  Gly Gln Arg Met Thr  Val Glu Glu Ala Val  Arg Glu Gly 
    1790                 1795                 1800             


Val Ile  Asp Arg Asp Thr Ala  Ser Ser Ile Leu Thr  Tyr Gln Val 
    1805                 1810                 1815             


Gln Thr  Gly Gly Ile Ile Gln  Ser Asn Pro Ala Lys  Arg Leu Thr 
    1820                 1825                 1830             


Val Asp  Glu Ala Val Gln Cys  Asp Leu Ile Thr Ser  Ser Ser Ala 
    1835                 1840                 1845             


Leu Leu  Val Leu Glu Ala Gln  Arg Gly Tyr Val Gly  Leu Ile Trp 
    1850                 1855                 1860             


Pro His  Ser Gly Glu Ile Phe  Pro Thr Ser Ser Ser  Leu Gln Gln 
    1865                 1870                 1875             


Glu Leu  Ile Thr Asn Glu Leu  Ala Tyr Lys Ile Leu  Asn Gly Arg 
    1880                 1885                 1890             


Gln Lys  Ile Ala Ala Leu Tyr  Ile Pro Glu Ser Ser  Gln Val Ile 
    1895                 1900                 1905             


Gly Leu  Asp Ala Ala Lys Gln  Leu Gly Ile Ile Asp  Asn Asn Thr 
    1910                 1915                 1920             


Ala Ser  Ile Leu Lys Asn Ile  Thr Leu Pro Asp Lys  Met Pro Asp 
    1925                 1930                 1935             


Leu Gly  Asp Leu Glu Ala Cys  Lys Asn Ala Arg Arg  Trp Leu Ser 
    1940                 1945                 1950             


Phe Cys  Lys Phe Gln Pro Ser  Thr Val His Asp Tyr  Arg Gln Glu 
    1955                 1960                 1965             


Glu Asp  Val Phe Asp Gly Glu  Glu Pro Val Thr Thr  Gln Thr Ser 
    1970                 1975                 1980             


Glu Glu  Thr Lys Lys Leu Phe  Leu Ser Tyr Leu Met  Ile Asn Ser 
    1985                 1990                 1995             


Tyr Met  Asp Ala Asn Thr Gly  Gln Arg Leu Leu Leu  Tyr Asp Gly 
    2000                 2005                 2010             


Asp Leu  Asp Glu Ala Val Gly  Met Leu Leu Glu Gly  Cys His Ala 
    2015                 2020                 2025             


Glu Phe  Asp Gly Asn Thr Ala  Ile Lys Glu Cys Leu  Asp Val Leu 
    2030                 2035                 2040             


Ser Ser  Ser Gly Val Phe Leu  Asn Asn Ala Ser Gly  Arg Glu Lys 
    2045                 2050                 2055             


Asp Glu  Cys Thr Ala Thr Pro  Ser Ser Phe Asn Lys  Cys His Cys 
    2060                 2065                 2070             


Gly Glu  Pro Glu His Glu Glu  Thr Pro Glu Asn Arg  Lys Cys Ala 
    2075                 2080                 2085             


Ile Asp  Glu Glu Phe Asn Glu  Met Arg Asn Thr Val  Ile Asn Ser 
    2090                 2095                 2100             


Glu Phe  Ser Gln Ser Gly Lys  Leu Ala Ser Thr Ile  Ser Ile Asp 
    2105                 2110                 2115             


Pro Lys  Val Asn Ser Ser Pro  Ser Val Cys Val Pro  Ser Leu Ile 
    2120                 2125                 2130             


Ser Tyr  Leu Thr Gln Thr Glu  Leu Ala Asp Ile Ser  Met Leu Arg 
    2135                 2140                 2145             


Ser Asp  Ser Glu Asn Ile Leu  Thr Asn Tyr Glu Asn  Gln Ser Arg 
    2150                 2155                 2160             


Val Glu  Thr Asn Glu Arg Ala  Asn Glu Cys Ser His  Ser Lys Asn 
    2165                 2170                 2175             


Ile Gln  Asn Phe Pro Ser Asp  Leu Ile Glu Asn Pro  Ile Met Lys 
    2180                 2185                 2190             


Ser Lys  Met Ser Lys Phe Cys  Gly Val Asn Glu Thr  Glu Asn Glu 
    2195                 2200                 2205             


Asp Asn  Thr Asn Arg Asp Ser  Pro Ile Phe Asp Tyr  Ser Pro Arg 
    2210                 2215                 2220             


Leu Ser  Ala Leu Leu Ser His  Asp Lys Leu Met His  Ser Gln Gly 
    2225                 2230                 2235             


Ser Phe  Asn Asp Thr His Thr  Pro Glu Ser Asn Gly  Asn Lys Cys 
    2240                 2245                 2250             


Glu Ala  Pro Ala Leu Ser Phe  Ser Asp Lys Thr Met  Leu Ser Gly 
    2255                 2260                 2265             


Gln Arg  Ile Gly Glu Lys Phe  Gln Asp Gln Phe Leu  Gly Ile Ala 
    2270                 2275                 2280             


Ala Ile  Asn Ile Ser Leu Pro  Gly Glu Gln Tyr Gly  Gln Lys Ser 
    2285                 2290                 2295             


Leu Asn  Met Ile Ser Ser Asn  Pro Gln Val Gln Tyr  His Asn Asp 
    2300                 2305                 2310             


Lys Tyr  Ile Ser Asn Thr Ser  Gly Glu Asp Glu Lys  Thr His Pro 
    2315                 2320                 2325             


Gly Phe  Gln Gln Met Pro Glu  Asp Lys Glu Asp Glu  Ser Glu Ile 
    2330                 2335                 2340             


Glu Glu  Tyr Ser Cys Ala Val  Thr Pro Gly Gly Asp  Thr Asp Asn 
    2345                 2350                 2355             


Ala Ile  Val Ser Leu Thr Cys  Ala Thr Pro Leu Leu  Asp Glu Thr 
    2360                 2365                 2370             


Ile Ser  Ala Ser Asp Tyr Glu  Thr Ser Leu Leu Asn  Asp Gln Gln 
    2375                 2380                 2385             


Asn Asn  Thr Gly Thr Asp Thr  Asp Ser Asp Asp Asp  Phe Tyr Asp 
    2390                 2395                 2400             


Thr Pro  Leu Phe Glu Asp Asp  Asp His Asp Ser Leu  Leu Leu Asp 
    2405                 2410                 2415             


Gly Asp  Asp Arg Asp Cys Leu  His Pro Glu Asp Tyr  Asp Thr Leu 
    2420                 2425                 2430             


Gln Glu  Glu Asn Asp Glu Thr  Ala Ser Pro Ala Asp  Val Phe Tyr 
    2435                 2440                 2445             


Asp Val  Ser Lys Glu Asn Glu  Asn Ser Met Val Pro  Gln Gly Ala 
    2450                 2455                 2460             


Pro Val  Gly Ser Leu Ser Val  Lys Asn Lys Ala His  Cys Leu Gln 
    2465                 2470                 2475             


Asp Phe  Leu Met Asp Val Glu  Lys Asp Glu Leu Asp  Ser Gly Glu 
    2480                 2485                 2490             


Lys Ile  His Leu Asn Pro Val  Gly Ser Asp Lys Val  Asn Gly Gln 
    2495                 2500                 2505             


Ser Leu  Glu Thr Gly Ser Glu  Arg Glu Cys Thr Asn  Ile Leu Glu 
    2510                 2515                 2520             


Gly Asp  Glu Ser Asp Ser Leu  Thr Asp Tyr Asp Ile  Val Gly Gly 
    2525                 2530                 2535             


Lys Glu  Ser Phe Thr Ala Ser  Leu Lys Phe Asp Asp  Ser Gly Ser 
    2540                 2545                 2550             


Trp Arg  Gly Arg Lys Glu Glu  Tyr Val Thr Gly Gln  Glu Phe His 
    2555                 2560                 2565             


Ser Asp  Thr Asp His Leu Asp  Ser Met Gln Ser Glu  Glu Ser Tyr 
    2570                 2575                 2580             


Gly Asp  Tyr Ile Tyr Asp Ser  Asn Asp Gln Asp Asp  Asp Asp Asp 
    2585                 2590                 2595             


Asp Gly  Ile Asp Glu Glu Gly  Gly Gly Ile Arg Asp  Glu Asn Gly 
    2600                 2605                 2610             


Lys Pro  Arg Cys Gln Asn Val  Ala Glu Asp Met Asp  Ile Gln Leu 
    2615                 2620                 2625             


Cys Ala  Ser Ile Leu Asn Glu  Asn Ser Asp Glu Asn  Glu Asn Ile 
    2630                 2635                 2640             


Asn Thr  Met Ile Leu Leu Asp  Lys Met His Ser Cys  Ser Ser Leu 
    2645                 2650                 2655             


Glu Lys  Gln Gln Arg Val Asn  Val Val Gln Leu Ala  Ser Pro Ser 
    2660                 2665                 2670             


Glu Asn  Asn Leu Val Thr Glu  Lys Ser Asn Leu Pro  Glu Tyr Thr 
    2675                 2680                 2685             


Thr Glu  Ile Ala Gly Lys Ser  Lys Glu Asn Leu Leu  Asn His Glu 
    2690                 2695                 2700             


Met Val  Leu Lys Asp Val Leu  Pro Pro Ile Ile Lys  Asp Thr Glu 
    2705                 2710                 2715             


Ser Glu  Lys Thr Phe Gly Pro  Ala Ser Ile Ser His  Asp Asn Asn 
    2720                 2725                 2730             


Asn Ile  Ser Ser Thr Ser Glu  Leu Gly Thr Asp Leu  Ala Asn Thr 
    2735                 2740                 2745             


Lys Val  Lys Leu Ile Gln Gly  Ser Glu Leu Pro Glu  Leu Thr Asp 
    2750                 2755                 2760             


Ser Val  Lys Gly Lys Asp Glu  Tyr Phe Lys Asn Met  Thr Pro Lys 
    2765                 2770                 2775             


Val Asp  Ser Ser Leu Asp His  Ile Ile Cys Thr Glu  Pro Asp Leu 
    2780                 2785                 2790             


Ile Gly  Lys Pro Ala Glu Glu  Ser His Leu Ser Leu  Ile Ala Ser 
    2795                 2800                 2805             


Val Thr  Asp Lys Asp Pro Gln  Gly Asn Gly Ser Asp  Leu Ile Lys 
    2810                 2815                 2820             


Gly Arg  Asp Gly Lys Ser Asp  Ile Leu Ile Glu Asp  Glu Thr Ser 
    2825                 2830                 2835             


Ile Gln  Lys Met Tyr Leu Gly  Glu Gly Glu Val Leu  Val Glu Gly 
    2840                 2845                 2850             


Leu Val  Glu Glu Glu Asn Arg  His Leu Lys Leu Leu  Pro Gly Lys 
    2855                 2860                 2865             


Asn Thr  Arg Asp Ser Phe Lys  Leu Ile Asn Ser Gln  Phe Pro Phe 
    2870                 2875                 2880             


Pro Gln  Ile Thr Asn Asn Glu  Glu Leu Asn Gln Lys  Gly Ser Leu 
    2885                 2890                 2895             


Lys Lys  Ala Thr Val Thr Leu  Lys Asp Glu Pro Asn  Asn Leu Gln 
    2900                 2905                 2910             


Ile Ile  Val Ser Lys Ser Pro  Val Gln Phe Glu Asn  Leu Glu Glu 
    2915                 2920                 2925             


Ile Phe  Asp Thr Ser Val Ser  Lys Glu Ile Ser Asp  Asp Ile Thr 
    2930                 2935                 2940             


Ser Asp  Ile Thr Ser Trp Glu  Gly Asn Thr His Phe  Glu Glu Ser 
    2945                 2950                 2955             


Phe Thr  Asp Gly Pro Glu Lys  Glu Leu Asp Leu Phe  Thr Tyr Leu 
    2960                 2965                 2970             


Lys His  Cys Ala Lys Asn Ile  Lys Ala Lys Asp Val  Ala Lys Pro 
    2975                 2980                 2985             


Asn Glu  Asp Val Pro Ser His  Val Leu Ile Thr Ala  Pro Pro Met 
    2990                 2995                 3000             


Lys Glu  His Leu Gln Leu Gly  Val Asn Asn Thr Lys  Glu Lys Ser 
    3005                 3010                 3015             


Thr Ser  Thr Gln Lys Asp Ser  Pro Leu Asn Asp Met  Ile Gln Ser 
    3020                 3025                 3030             


Asn Asp  Leu Cys Ser Lys Glu  Ser Ile Ser Gly Gly  Gly Thr Glu 
    3035                 3040                 3045             


Ile Ser  Gln Phe Thr Pro Glu  Ser Ile Glu Ala Thr  Leu Ser Ile 
    3050                 3055                 3060             


Leu Ser  Arg Lys His Val Glu  Asp Val Gly Lys Asn  Asp Phe Leu 
    3065                 3070                 3075             


Gln Ser  Glu Arg Cys Ala Asn  Gly Leu Gly Asn Asp  Asn Ser Ser 
    3080                 3085                 3090             


Asn Thr  Leu Asn Thr Asp Tyr  Ser Phe Leu Glu Ile  Asn Asn Lys 
    3095                 3100                 3105             


Lys Glu  Arg Ile Glu Gln Gln  Leu Pro Lys Glu Gln  Ala Leu Ser 
    3110                 3115                 3120             


Pro Arg  Ser Gln Glu Lys Glu  Val Gln Ile Pro Glu  Leu Ser Gln 
    3125                 3130                 3135             


Val Phe  Val Glu Asp Val Lys  Asp Ile Leu Lys Ser  Arg Leu Lys 
    3140                 3145                 3150             


Glu Gly  His Met Asn Pro Gln  Glu Val Glu Glu Pro  Ser Ala Cys 
    3155                 3160                 3165             


Ala Asp  Thr Lys Ile Leu Ile  Gln Asn Leu Ile Lys  Arg Ile Thr 
    3170                 3175                 3180             


Thr Ser  Gln Leu Val Asn Glu  Ala Ser Thr Val Pro  Ser Asp Ser 
    3185                 3190                 3195             


Gln Met  Ser Asp Ser Ser Gly  Val Ser Pro Met Thr  Asn Ser Ser 
    3200                 3205                 3210             


Glu Leu  Lys Pro Glu Ser Arg  Asp Asp Pro Phe Cys  Ile Gly Asn 
    3215                 3220                 3225             


Leu Lys  Ser Glu Leu Leu Leu  Asn Ile Leu Lys Gln  Asp Gln His 
    3230                 3235                 3240             


Ser Gln  Lys Ile Thr Gly Val  Phe Glu Leu Met Arg  Glu Leu Thr 
    3245                 3250                 3255             


His Met  Glu Tyr Asp Leu Glu  Lys Arg Gly Ile Thr  Ser Lys Val 
    3260                 3265                 3270             


Leu Pro  Leu Gln Leu Glu Asn  Ile Phe Tyr Lys Leu  Leu Ala Asp 
    3275                 3280                 3285             


Gly Tyr  Ser Glu Lys Ile Glu  His Val Gly Asp Phe  Asn Gln Lys 
    3290                 3295                 3300             


Ala Cys  Ser Thr Ser Glu Met  Met Glu Glu Lys Pro  His Ile Leu 
    3305                 3310                 3315             


Gly Asp  Ile Lys Ser Lys Glu  Gly Asn Tyr Tyr Ser  Pro Asn Leu 
    3320                 3325                 3330             


Glu Thr  Val Lys Glu Ile Gly  Leu Glu Ser Ser Thr  Val Trp Ala 
    3335                 3340                 3345             


Ser Thr  Leu Pro Arg Asp Glu  Lys Leu Lys Asp Leu  Cys Asn Asp 
    3350                 3355                 3360             


Phe Pro  Ser His Leu Glu Cys  Thr Ser Gly Ser Lys  Glu Met Ala 
    3365                 3370                 3375             


Ser Gly  Asp Ser Ser Thr Glu  Gln Phe Ser Ser Glu  Leu Gln Gln 
    3380                 3385                 3390             


Cys Leu  Gln His Thr Glu Lys  Met His Glu Tyr Leu  Thr Leu Leu 
    3395                 3400                 3405             


Gln Asp  Met Lys Pro Pro Leu  Asp Asn Gln Glu Ser  Leu Asp Asn 
    3410                 3415                 3420             


Asn Leu  Glu Ala Leu Lys Asn  Gln Leu Arg Gln Leu  Glu Thr Phe 
    3425                 3430                 3435             


Glu Leu  Gly Leu Ala Pro Ile  Ala Val Ile Leu Arg  Lys Asp Met 
    3440                 3445                 3450             


Lys Leu  Ala Glu Glu Phe Leu  Lys Ser Leu Pro Ser  Asp Phe Pro 
    3455                 3460                 3465             


Arg Gly  His Val Glu Glu Leu  Ser Ile Ser His Gln  Ser Leu Lys 
    3470                 3475                 3480             


Thr Ala  Phe Ser Ser Leu Ser  Asn Val Ser Ser Glu  Arg Thr Lys 
    3485                 3490                 3495             


Gln Ile  Met Leu Ala Ile Asp  Ser Glu Met Ser Lys  Leu Ala Val 
    3500                 3505                 3510             


Ser His  Glu Glu Phe Leu His  Lys Leu Lys Ser Phe  Ser Asp Trp 
    3515                 3520                 3525             


Val Ser  Glu Lys Ser Lys Ser  Val Lys Asp Ile Glu  Ile Val Asn 
    3530                 3535                 3540             


Val Gln  Asp Ser Glu Tyr Val  Lys Lys Arg Leu Glu  Phe Leu Lys 
    3545                 3550                 3555             


Asn Val  Leu Lys Asp Leu Gly  His Thr Lys Met Gln  Leu Glu Thr 
    3560                 3565                 3570             


Thr Ala  Phe Asp Val Gln Phe  Phe Ile Ser Glu Tyr  Ala Gln Asp 
    3575                 3580                 3585             


Leu Ser  Pro Asn Gln Ser Lys  Gln Leu Leu Arg Leu  Leu Asn Thr 
    3590                 3595                 3600             


Thr Gln  Lys Cys Phe Leu Asp  Val Gln Glu Ser Val  Thr Thr Gln 
    3605                 3610                 3615             


Val Glu  Arg Leu Glu Thr Gln  Leu His Leu Glu Gln  Asp Leu Asp 
    3620                 3625                 3630             


Asp Gln  Lys Ile Val Ala Glu  Arg Gln Gln Glu Tyr  Lys Glu Lys 
    3635                 3640                 3645             


Leu Gln  Gly Ile Cys Asp Leu  Leu Thr Gln Thr Glu  Asn Arg Leu 
    3650                 3655                 3660             


Ile Gly  His Gln Glu Ala Phe  Met Ile Gly Asp Gly  Thr Val Glu 
    3665                 3670                 3675             


Leu Lys  Lys Tyr Gln Ser Lys  Gln Glu Glu Leu Gln  Lys Asp Met 
    3680                 3685                 3690             


Gln Gly  Ser Ala Gln Ala Leu  Ala Glu Val Val Lys  Asn Thr Glu 
    3695                 3700                 3705             


Asn Phe  Leu Lys Glu Asn Gly  Glu Lys Leu Ser Gln  Glu Asp Lys 
    3710                 3715                 3720             


Ala Leu  Ile Glu Gln Lys Leu  Asn Glu Ala Lys Ile  Lys Cys Glu 
    3725                 3730                 3735             


Gln Leu  Asn Leu Lys Ala Glu  Gln Ser Lys Lys Glu  Leu Asp Lys 
    3740                 3745                 3750             


Val Val  Thr Thr Ala Ile Lys  Glu Glu Thr Glu Lys  Val Ala Ala 
    3755                 3760                 3765             


Val Lys  Gln Leu Glu Glu Ser  Lys Thr Lys Ile Glu  Asn Leu Leu 
    3770                 3775                 3780             


Asp Trp  Leu Ser Asn Val Asp  Lys Asp Ser Glu Arg  Ala Gly Thr 
    3785                 3790                 3795             


Lys His  Lys Gln Val Ile Glu  Gln Asn Gly Thr His  Phe Gln Glu 
    3800                 3805                 3810             


Gly Asp  Gly Lys Ser Ala Ile  Gly Glu Glu Asp Glu  Val Asn Gly 
    3815                 3820                 3825             


Asn Leu  Leu Glu Thr Asp Val  Asp Gly Gln Val Gly  Thr Thr Gln 
    3830                 3835                 3840             


Glu Asn  Leu Asn Gln Gln Tyr  Gln Lys Val Lys Ala  Gln His Glu 
    3845                 3850                 3855             


Lys Ile  Ile Ser Gln His Gln  Ala Val Ile Ile Ala  Thr Gln Ser 
    3860                 3865                 3870             


Ala Gln  Val Leu Leu Glu Lys  Gln Gly Gln Tyr Leu  Ser Pro Glu 
    3875                 3880                 3885             


Glu Lys  Glu Lys Leu Gln Lys  Asn Met Lys Glu Leu  Lys Val His 
    3890                 3895                 3900             


Tyr Glu  Thr Ala Leu Ala Glu  Ser Glu Lys Lys Met  Lys Leu Thr 
    3905                 3910                 3915             


His Ser  Leu Gln Glu Glu Leu  Glu Lys Phe Asp Ala  Asp Tyr Thr 
    3920                 3925                 3930             


Glu Phe  Glu His Trp Leu Gln  Gln Ser Glu Gln Glu  Leu Glu Asn 
    3935                 3940                 3945             


Leu Glu  Ala Gly Ala Asp Asp  Ile Asn Gly Leu Met  Thr Lys Leu 
    3950                 3955                 3960             


Lys Arg  Gln Lys Ser Phe Ser  Glu Asp Val Ile Ser  His Lys Gly 
    3965                 3970                 3975             


Asp Leu  Arg Tyr Ile Thr Ile  Ser Gly Asn Arg Val  Leu Glu Ala 
    3980                 3985                 3990             


Ala Lys  Ser Cys Ser Lys Arg  Asp Gly Gly Lys Val  Asp Thr Ser 
    3995                 4000                 4005             


Ala Thr  His Arg Glu Val Gln  Arg Lys Leu Asp His  Ala Thr Asp 
    4010                 4015                 4020             


Arg Phe  Arg Ser Leu Tyr Ser  Lys Cys Asn Val Leu  Gly Asn Asn 
    4025                 4030                 4035             


Leu Lys  Asp Leu Val Asp Lys  Tyr Gln His Tyr Glu  Asp Ala Ser 
    4040                 4045                 4050             


Cys Gly  Leu Leu Ala Gly Leu  Gln Ala Cys Glu Ala  Thr Ala Ser 
    4055                 4060                 4065             


Lys His  Leu Ser Glu Pro Ile  Ala Val Asp Pro Lys  Asn Leu Gln 
    4070                 4075                 4080             


Arg Gln  Leu Glu Glu Thr Lys  Ala Leu Gln Gly Gln  Ile Ser Ser 
    4085                 4090                 4095             


Gln Gln  Val Ala Val Glu Lys  Leu Lys Lys Thr Ala  Glu Val Leu 
    4100                 4105                 4110             


Leu Asp  Ala Arg Gly Ser Leu  Leu Pro Ala Lys Asn  Asp Ile Gln 
    4115                 4120                 4125             


Lys Thr  Leu Asp Asp Ile Val  Gly Arg Tyr Glu Asp  Leu Ser Lys 
    4130                 4135                 4140             


Ser Val  Asn Glu Arg Asn Glu  Lys Leu Gln Ile Thr  Leu Thr Arg 
    4145                 4150                 4155             


Ser Leu  Ser Val Gln Asp Gly  Leu Asp Glu Met Leu  Asp Trp Met 
    4160                 4165                 4170             


Gly Asn  Val Glu Ser Ser Leu  Lys Glu Gln Gly Gln  Val Pro Leu 
    4175                 4180                 4185             


Asn Ser  Thr Ala Leu Gln Asp  Ile Ile Ser Lys Asn  Ile Met Leu 
    4190                 4195                 4200             


Glu Gln  Asp Ile Ala Gly Arg  Gln Ser Ser Ile Asn  Ala Met Asn 
    4205                 4210                 4215             


Glu Lys  Val Lys Lys Phe Met  Glu Thr Thr Asp Pro  Ser Thr Ala 
    4220                 4225                 4230             


Ser Ser  Leu Gln Ala Lys Met  Lys Asp Leu Ser Ala  Arg Phe Ser 
    4235                 4240                 4245             


Glu Ala  Ser His Lys His Lys  Glu Thr Leu Ala Lys  Met Glu Glu 
    4250                 4255                 4260             


Leu Lys  Thr Lys Val Glu Leu  Phe Glu Asn Leu Ser  Glu Lys Leu 
    4265                 4270                 4275             


Gln Thr  Phe Leu Glu Thr Lys  Thr Gln Ala Leu Thr  Glu Val Asp 
    4280                 4285                 4290             


Val Pro  Gly Lys Asp Val Thr  Glu Leu Ser Gln Tyr  Met Gln Glu 
    4295                 4300                 4305             


Ser Thr  Ser Glu Phe Leu Glu  His Lys Lys His Leu  Glu Val Leu 
    4310                 4315                 4320             


His Ser  Leu Leu Lys Glu Ile  Ser Ser His Gly Leu  Pro Ser Asp 
    4325                 4330                 4335             


Lys Ala  Leu Val Leu Glu Lys  Thr Asn Asn Leu Ser  Lys Lys Phe 
    4340                 4345                 4350             


Lys Glu  Met Glu Asp Thr Ile  Lys Glu Lys Lys Glu  Ala Val Thr 
    4355                 4360                 4365             


Ser Cys  Gln Glu Gln Leu Asp  Ala Phe Gln Val Leu  Val Lys Ser 
    4370                 4375                 4380             


Leu Lys  Ser Trp Ile Lys Glu  Thr Thr Lys Lys Val  Pro Ile Val 
    4385                 4390                 4395             


Gln Pro  Ser Phe Gly Ala Glu  Asp Leu Gly Lys Ser  Leu Glu Asp 
    4400                 4405                 4410             


Thr Lys  Lys Leu Gln Glu Lys  Trp Ser Leu Lys Thr  Pro Glu Ile 
    4415                 4420                 4425             


Gln Lys  Val Asn Asn Ser Gly  Ile Ser Leu Cys Asn  Leu Ile Ser 
    4430                 4435                 4440             


Ala Val  Thr Thr Pro Ala Lys  Ala Ile Ala Ala Val  Lys Ser Gly 
    4445                 4450                 4455             


Gly Ala  Val Leu Asn Gly Glu  Gly Thr Ala Thr Asn  Thr Glu Glu 
    4460                 4465                 4470             


Phe Trp  Ala Asn Lys Gly Leu  Thr Ser Ile Lys Lys  Asp Met Thr 
    4475                 4480                 4485             


Asp Ile  Ser His Gly Tyr Glu  Asp Leu Gly Leu Leu  Leu Lys Asp 
    4490                 4495                 4500             


Lys Ile  Ala Glu Leu Asn Thr  Lys Leu Ser Lys Leu  Gln Lys Ala 
    4505                 4510                 4515             


Gln Glu  Glu Ser Ser Ala Met  Met Gln Trp Leu Gln  Lys Met Asn 
    4520                 4525                 4530             


Lys Thr  Ala Thr Lys Trp Gln  Gln Thr Pro Ala Pro  Thr Asp Thr 
    4535                 4540                 4545             


Glu Ala  Val Lys Thr Gln Val  Glu Gln Asn Lys Ser  Phe Glu Ala 
    4550                 4555                 4560             


Glu Leu  Lys Gln Asn Val Asn  Lys Val Gln Glu Leu  Lys Asp Lys 
    4565                 4570                 4575             


Leu Thr  Glu Leu Leu Glu Glu  Asn Pro Asp Thr Pro  Glu Ala Pro 
    4580                 4585                 4590             


Arg Trp  Lys Gln Met Leu Thr  Glu Ile Asp Ser Lys  Trp Gln Glu 
    4595                 4600                 4605             


Leu Asn  Gln Leu Thr Ile Asp  Arg Gln Gln Lys Leu  Glu Glu Ser 
    4610                 4615                 4620             


Ser Asn  Asn Leu Thr Gln Phe  Gln Thr Val Glu Ala  Gln Leu Lys 
    4625                 4630                 4635             


Gln Trp  Leu Val Glu Lys Glu  Leu Met Val Ser Val  Leu Gly Pro 
    4640                 4645                 4650             


Leu Ser  Ile Asp Pro Asn Met  Leu Asn Thr Gln Arg  Gln Gln Val 
    4655                 4660                 4665             


Gln Ile  Leu Leu Gln Glu Phe  Ala Thr Arg Lys Pro  Gln Tyr Glu 
    4670                 4675                 4680             


Gln Leu  Thr Ala Ala Gly Gln  Gly Ile Leu Ser Arg  Pro Gly Glu 
    4685                 4690                 4695             


Asp Pro  Ser Leu Arg Gly Ile  Val Lys Glu Gln Leu  Ala Ala Val 
    4700                 4705                 4710             


Thr Gln  Lys Trp Asp Ser Leu  Thr Gly Gln Leu Ser  Asp Arg Cys 
    4715                 4720                 4725             


Asp Trp  Ile Asp Gln Ala Ile  Val Lys Ser Thr Gln  Tyr Gln Ser 
    4730                 4735                 4740             


Leu Leu  Arg Ser Leu Ser Asp  Lys Leu Ser Asp Leu  Asp Asn Lys 
    4745                 4750                 4755             


Leu Ser  Ser Ser Leu Ala Val  Ser Thr His Pro Asp  Ala Met Asn 
    4760                 4765                 4770             


Gln Gln  Leu Glu Thr Ala Gln  Lys Met Lys Gln Glu  Ile Gln Gln 
    4775                 4780                 4785             


Glu Lys  Lys Gln Ile Lys Val  Ala Gln Ala Leu Cys  Glu Asp Leu 
    4790                 4795                 4800             


Ser Ala  Leu Val Lys Glu Glu  Tyr Leu Lys Ala Glu  Leu Ser Arg 
    4805                 4810                 4815             


Gln Leu  Glu Gly Ile Leu Lys  Ser Phe Lys Asp Val  Glu Gln Lys 
    4820                 4825                 4830             


Ala Glu  Asn His Val Gln His  Leu Gln Ser Ala Cys  Ala Ser Ser 
    4835                 4840                 4845             


His Gln  Phe Gln Gln Met Ser  Arg Asp Phe Gln Ala  Trp Leu Asp 
    4850                 4855                 4860             


Thr Lys  Lys Glu Glu Gln Asn  Lys Ser His Pro Ile  Ser Ala Lys 
    4865                 4870                 4875             


Leu Asp  Val Leu Glu Ser Leu  Ile Lys Asp His Lys  Asp Phe Ser 
    4880                 4885                 4890             


Lys Thr  Leu Thr Ala Gln Ser  His Met Tyr Glu Lys  Thr Ile Ala 
    4895                 4900                 4905             


Glu Gly  Glu Asn Leu Leu Leu  Lys Thr Gln Gly Ser  Glu Lys Ala 
    4910                 4915                 4920             


Ala Leu  Gln Leu Gln Leu Asn  Thr Ile Lys Thr Asn  Trp Asp Thr 
    4925                 4930                 4935             


Phe Asn  Lys Gln Val Lys Glu  Arg Glu Asn Lys Leu  Lys Glu Ser 
    4940                 4945                 4950             


Leu Glu  Lys Ala Leu Lys Tyr  Lys Glu Gln Val Glu  Thr Leu Trp 
    4955                 4960                 4965             


Pro Trp  Ile Asp Lys Cys Gln  Asn Asn Leu Glu Glu  Ile Lys Phe 
    4970                 4975                 4980             


Cys Leu  Asp Pro Ala Glu Gly  Glu Asn Ser Ile Ala  Lys Leu Lys 
    4985                 4990                 4995             


Ser Leu  Gln Lys Glu Met Asp  Gln His Phe Gly Met  Val Glu Leu 
    5000                 5005                 5010             


Leu Asn  Asn Thr Ala Asn Ser  Leu Leu Ser Val Cys  Glu Ile Asp 
    5015                 5020                 5025             


Lys Glu  Val Val Thr Asp Glu  Asn Lys Ser Leu Ile  Gln Lys Val 
    5030                 5035                 5040             


Asp Met  Val Thr Glu Gln Leu  His Ser Lys Lys Phe  Cys Leu Glu 
    5045                 5050                 5055             


Asn Met  Thr Gln Lys Phe Lys  Glu Phe Gln Glu Val  Ser Lys Glu 
    5060                 5065                 5070             


Ser Lys  Arg Gln Leu Gln Cys  Ala Lys Glu Gln Leu  Asp Ile His 
    5075                 5080                 5085             


Asp Ser  Leu Gly Ser Gln Ala  Tyr Ser Asn Lys Tyr  Leu Thr Met 
    5090                 5095                 5100             


Leu Gln  Thr Gln Gln Lys Ser  Leu Gln Ala Leu Lys  His Gln Val 
    5105                 5110                 5115             


Asp Leu  Ala Lys Arg Leu Ala  Gln Asp Leu Val Val  Glu Ala Ser 
    5120                 5125                 5130             


Asp Ser  Lys Gly Thr Ser Asp  Val Leu Leu Gln Val  Glu Thr Ile 
    5135                 5140                 5145             


Ala Gln  Glu His Ser Thr Leu  Ser Gln Gln Val Asp  Glu Lys Cys 
    5150                 5155                 5160             


Ser Phe  Leu Glu Thr Lys Leu  Gln Gly Ile Gly His  Phe Gln Asn 
    5165                 5170                 5175             


Thr Ile  Arg Glu Met Phe Ser  Gln Phe Ala Glu Phe  Asp Asp Glu 
    5180                 5185                 5190             


Leu Asp  Ser Met Ala Pro Val  Gly Arg Asp Ala Glu  Thr Leu Gln 
    5195                 5200                 5205             


Lys Gln  Lys Glu Thr Ile Lys  Ala Phe Leu Lys Lys  Leu Glu Ala 
    5210                 5215                 5220             


Leu Met  Ala Ser Asn Asp Asn  Ala Asn Lys Thr Cys  Lys Met Met 
    5225                 5230                 5235             


Leu Ala  Thr Glu Glu Thr Ser  Pro Asp Leu Val Gly  Ile Lys Arg 
    5240                 5245                 5250             


Asp Leu  Glu Ala Leu Ser Lys  Gln Cys Asn Lys Leu  Leu Asp Arg 
    5255                 5260                 5265             


Ala Gln  Ala Arg Glu Glu Gln  Val Glu Gly Thr Ile  Lys Arg Leu 
    5270                 5275                 5280             


Glu Glu  Phe Tyr Ser Lys Leu  Lys Glu Phe Ser Ile  Leu Leu Gln 
    5285                 5290                 5295             


Lys Ala  Glu Glu His Glu Glu  Ser Gln Gly Pro Val  Gly Met Glu 
    5300                 5305                 5310             


Thr Glu  Thr Ile Asn Gln Gln  Leu Asn Met Phe Lys  Val Phe Gln 
    5315                 5320                 5325             


Lys Glu  Glu Ile Glu Pro Leu  Gln Gly Lys Gln Gln  Asp Val Asn 
    5330                 5335                 5340             


Trp Leu  Gly Gln Gly Leu Ile  Gln Ser Ala Ala Lys  Ser Thr Ser 
    5345                 5350                 5355             


Thr Gln  Gly Leu Glu His Asp  Leu Asp Asp Val Asn  Ala Arg Trp 
    5360                 5365                 5370             


Lys Thr  Leu Asn Lys Lys Val  Ala Gln Arg Ala Ala  Gln Leu Gln 
    5375                 5380                 5385             


Glu Ala  Leu Leu His Cys Gly  Arg Phe Gln Asp Ala  Leu Glu Ser 
    5390                 5395                 5400             


Leu Leu  Ser Trp Met Val Asp  Thr Glu Glu Leu Val  Ala Asn Gln 
    5405                 5410                 5415             


Lys Pro  Pro Ser Ala Glu Phe  Lys Val Val Lys Ala  Gln Ile Gln 
    5420                 5425                 5430             


Glu Gln  Lys Leu Leu Gln Arg  Leu Leu Asp Asp Arg  Lys Ser Thr 
    5435                 5440                 5445             


Val Glu  Val Ile Lys Arg Glu  Gly Glu Lys Ile Ala  Thr Thr Ala 
    5450                 5455                 5460             


Glu Pro  Ala Asp Lys Val Lys  Ile Leu Lys Gln Leu  Ser Leu Leu 
    5465                 5470                 5475             


Asp Ser  Arg Trp Glu Ala Leu  Leu Asn Lys Ala Glu  Thr Arg Asn 
    5480                 5485                 5490             


Arg Gln  Leu Glu Gly Ile Ser  Val Val Ala Gln Gln  Phe His Glu 
    5495                 5500                 5505             


Thr Leu  Glu Pro Leu Asn Glu  Trp Leu Thr Thr Ile  Glu Lys Arg 
    5510                 5515                 5520             


Leu Val  Asn Cys Glu Pro Ile  Gly Thr Gln Ala Ser  Lys Leu Glu 
    5525                 5530                 5535             


Glu Gln  Ile Ala Gln His Lys  Ala Leu Glu Asp Asp  Ile Ile Asn 
    5540                 5545                 5550             


His Asn  Lys His Leu His Gln  Ala Val Ser Ile Gly  Gln Ser Leu 
    5555                 5560                 5565             


Lys Val  Leu Ser Ser Arg Glu  Asp Lys Asp Met Val  Gln Ser Lys 
    5570                 5575                 5580             


Leu Asp  Phe Ser Gln Val Trp  Tyr Ile Glu Ile Gln  Glu Lys Ser 
    5585                 5590                 5595             


His Ser  Arg Ser Glu Leu Leu  Gln Gln Ala Leu Cys  Asn Ala Lys 
    5600                 5605                 5610             


Ile Phe  Gly Glu Asp Glu Val  Glu Leu Met Asn Trp  Leu Asn Glu 
    5615                 5620                 5625             


Val His  Asp Lys Leu Ser Lys  Leu Ser Val Gln Asp  Tyr Ser Thr 
    5630                 5635                 5640             


Glu Gly  Leu Trp Lys Gln Gln  Ser Glu Leu Arg Val  Leu Gln Glu 
    5645                 5650                 5655             


Asp Ile  Leu Leu Arg Lys Gln  Asn Val Asp Gln Ala  Leu Leu Asn 
    5660                 5665                 5670             


Gly Leu  Glu Leu Leu Lys Gln  Thr Thr Gly Asp Glu  Val Leu Ile 
    5675                 5680                 5685             


Ile Gln  Asp Lys Leu Glu Ala  Ile Lys Ala Arg Tyr  Lys Asp Ile 
    5690                 5695                 5700             


Thr Lys  Leu Ser Thr Asp Val  Ala Lys Thr Leu Glu  Gln Ala Leu 
    5705                 5710                 5715             


Gln Leu  Ala Arg Arg Leu His  Ser Thr His Glu Glu  Leu Cys Thr 
    5720                 5725                 5730             


Trp Leu  Asp Lys Val Glu Val  Glu Leu Leu Ser Tyr  Glu Thr Gln 
    5735                 5740                 5745             


Val Leu  Lys Gly Glu Glu Ala  Ser Gln Ala Gln Met  Arg Pro Lys 
    5750                 5755                 5760             


Glu Leu  Lys Lys Glu Ala Lys  Asn Asn Lys Ala Leu  Leu Asp Ser 
    5765                 5770                 5775             


Leu Asn  Glu Val Ser Ser Ala  Leu Leu Glu Leu Val  Pro Trp Arg 
    5780                 5785                 5790             


Ala Arg  Glu Gly Leu Glu Lys  Met Val Ala Glu Asp  Asn Glu Arg 
    5795                 5800                 5805             


Tyr Arg  Leu Val Ser Asp Thr  Ile Thr Gln Lys Val  Glu Glu Ile 
    5810                 5815                 5820             


Asp Ala  Ala Ile Leu Arg Ser  Gln Gln Phe Asp Gln  Ala Ala Asp 
    5825                 5830                 5835             


Ala Glu  Leu Ser Trp Ile Thr  Glu Thr Glu Lys Lys  Leu Met Ser 
    5840                 5845                 5850             


Leu Gly  Asp Ile Arg Leu Glu  Gln Asp Gln Thr Ser  Ala Gln Leu 
    5855                 5860                 5865             


Gln Val  Gln Lys Thr Phe Thr  Met Glu Ile Leu Arg  His Lys Asp 
    5870                 5875                 5880             


Ile Ile  Asp Asp Leu Val Lys  Ser Gly His Lys Ile  Met Thr Ala 
    5885                 5890                 5895             


Cys Ser  Glu Glu Glu Lys Gln  Ser Met Lys Lys Lys  Leu Asp Lys 
    5900                 5905                 5910             


Val Leu  Lys Asn Tyr Asp Thr  Ile Cys Gln Ile Asn  Ser Glu Arg 
    5915                 5920                 5925             


Tyr Leu  Gln Leu Glu Arg Ala  Gln Ser Leu Val Asn  Gln Phe Trp 
    5930                 5935                 5940             


Glu Thr  Tyr Glu Glu Leu Trp  Pro Trp Leu Thr Glu  Thr Gln Ser 
    5945                 5950                 5955             


Ile Ile  Ser Gln Leu Pro Ala  Pro Ala Leu Glu Tyr  Glu Thr Leu 
    5960                 5965                 5970             


Arg Gln  Gln Gln Glu Glu His  Arg Gln Leu Arg Glu  Leu Ile Ala 
    5975                 5980                 5985             


Glu His  Lys Pro His Ile Asp  Lys Met Asn Lys Thr  Gly Pro Gln 
    5990                 5995                 6000             


Leu Leu  Glu Leu Ser Pro Gly  Glu Gly Phe Ser Ile  Gln Glu Lys 
    6005                 6010                 6015             


Tyr Val  Ala Ala Asp Thr Leu  Tyr Ser Gln Ile Lys  Glu Asp Val 
    6020                 6025                 6030             


Lys Lys  Arg Ala Val Ala Leu  Asp Glu Ala Ile Ser  Gln Ser Thr 
    6035                 6040                 6045             


Gln Phe  His Asp Lys Ile Asp  Gln Ile Leu Glu Ser  Leu Glu Arg 
    6050                 6055                 6060             


Ile Val  Glu Arg Leu Arg Gln  Pro Pro Ser Ile Ser  Ala Glu Val 
    6065                 6070                 6075             


Glu Lys  Ile Lys Glu Gln Ile  Ser Glu Asn Lys Asn  Val Ser Val 
    6080                 6085                 6090             


Asp Met  Glu Lys Leu Gln Pro  Leu Tyr Glu Thr Leu  Lys Gln Arg 
    6095                 6100                 6105             


Gly Glu  Glu Met Ile Ala Arg  Ser Gly Gly Thr Asp  Lys Asp Ile 
    6110                 6115                 6120             


Ser Ala  Lys Ala Val Gln Asp  Lys Leu Asp Gln Met  Val Phe Ile 
    6125                 6130                 6135             


Trp Glu  Asn Ile His Thr Leu  Val Glu Glu Arg Glu  Ala Lys Leu 
    6140                 6145                 6150             


Leu Asp  Val Met Glu Leu Ala  Glu Lys Phe Trp Cys  Asp His Met 
    6155                 6160                 6165             


Ser Leu  Ile Val Thr Ile Lys  Asp Thr Gln Asp Phe  Ile Arg Asp 
    6170                 6175                 6180             


Leu Glu  Asp Pro Gly Ile Asp  Pro Ser Val Val Lys  Gln Gln Gln 
    6185                 6190                 6195             


Glu Ala  Ala Glu Thr Ile Arg  Glu Glu Ile Asp Gly  Leu Gln Glu 
    6200                 6205                 6210             


Glu Leu  Asp Ile Val Ile Asn  Leu Gly Ser Glu Leu  Ile Ala Ala 
    6215                 6220                 6225             


Cys Gly  Glu Pro Asp Lys Pro  Ile Val Lys Lys Ser  Ile Asp Glu 
    6230                 6235                 6240             


Leu Asn  Ser Ala Trp Asp Ser  Leu Asn Lys Ala Trp  Lys Asp Arg 
    6245                 6250                 6255             


Ile Asp  Lys Leu Glu Glu Ala  Met Gln Ala Ala Val  Gln Tyr Gln 
    6260                 6265                 6270             


Asp Gly  Leu Gln Ala Val Phe  Asp Trp Val Asp Ile  Ala Gly Gly 
    6275                 6280                 6285             


Lys Leu  Ala Ser Met Ser Pro  Ile Gly Thr Asp Leu  Glu Thr Val 
    6290                 6295                 6300             


Lys Gln  Gln Ile Glu Glu Leu  Lys Gln Phe Lys Ser  Glu Ala Tyr 
    6305                 6310                 6315             


Gln Gln  Gln Ile Glu Met Glu  Arg Leu Asn His Gln  Ala Glu Leu 
    6320                 6325                 6330             


Leu Leu  Lys Lys Val Thr Glu  Glu Ser Asp Lys His  Thr Val Gln 
    6335                 6340                 6345             


Asp Pro  Leu Met Glu Leu Lys  Leu Ile Trp Asp Ser  Leu Glu Glu 
    6350                 6355                 6360             


Arg Ile  Ile Asn Arg Gln His  Lys Leu Glu Gly Ala  Leu Leu Ala 
    6365                 6370                 6375             


Leu Gly  Gln Phe Gln His Ala  Leu Asp Glu Leu Leu  Ala Trp Leu 
    6380                 6385                 6390             


Thr His  Thr Glu Gly Leu Leu  Ser Glu Gln Lys Pro  Val Gly Gly 
    6395                 6400                 6405             


Asp Pro  Lys Ala Ile Glu Ile  Glu Leu Ala Lys His  His Val Leu 
    6410                 6415                 6420             


Gln Asn  Asp Val Leu Ala His  Gln Ser Thr Val Glu  Ala Val Asn 
    6425                 6430                 6435             


Lys Ala  Gly Asn Asp Leu Ile  Glu Ser Ser Ala Gly  Glu Glu Ala 
    6440                 6445                 6450             


Ser Asn  Leu Gln Asn Lys Leu  Glu Val Leu Asn Gln  Arg Trp Gln 
    6455                 6460                 6465             


Asn Val  Leu Glu Lys Thr Glu  Gln Arg Lys Gln Gln  Leu Asp Gly 
    6470                 6475                 6480             


Ala Leu  Arg Gln Ala Lys Gly  Phe His Gly Glu Ile  Glu Asp Leu 
    6485                 6490                 6495             


Gln Gln  Trp Leu Thr Asp Thr  Glu Arg His Leu Leu  Ala Ser Lys 
    6500                 6505                 6510             


Pro Leu  Gly Gly Leu Pro Glu  Thr Ala Lys Glu Gln  Leu Asn Val 
    6515                 6520                 6525             


His Met  Glu Val Cys Ala Ala  Phe Glu Ala Lys Glu  Glu Thr Tyr 
    6530                 6535                 6540             


Lys Ser  Leu Met Gln Lys Gly  Gln Gln Met Leu Ala  Arg Cys Pro 
    6545                 6550                 6555             


Lys Ser  Ala Glu Thr Asn Ile  Asp Gln Asp Ile Asn  Asn Leu Lys 
    6560                 6565                 6570             


Glu Lys  Trp Glu Ser Val Glu  Thr Lys Leu Asn Glu  Arg Lys Thr 
    6575                 6580                 6585             


Lys Leu  Glu Glu Ala Leu Asn  Leu Ala Met Glu Phe  His Asn Ser 
    6590                 6595                 6600             


Leu Gln  Asp Phe Ile Asn Trp  Leu Thr Gln Ala Glu  Gln Thr Leu 
    6605                 6610                 6615             


Asn Val  Ala Ser Arg Pro Ser  Leu Ile Leu Asp Thr  Val Leu Phe 
    6620                 6625                 6630             


Gln Ile  Asp Glu His Lys Val  Phe Ala Asn Glu Val  Asn Ser His 
    6635                 6640                 6645             


Arg Glu  Gln Ile Ile Glu Leu  Asp Lys Thr Gly Thr  His Leu Lys 
    6650                 6655                 6660             


Tyr Phe  Ser Gln Lys Gln Asp  Val Val Leu Ile Lys  Asn Leu Leu 
    6665                 6670                 6675             


Ile Ser  Val Gln Ser Arg Trp  Glu Lys Val Val Gln  Arg Leu Val 
    6680                 6685                 6690             


Glu Arg  Gly Arg Ser Leu Asp  Asp Ala Arg Lys Arg  Ala Lys Gln 
    6695                 6700                 6705             


Phe His  Glu Ala Trp Ser Lys  Leu Met Glu Trp Leu  Glu Glu Ser 
    6710                 6715                 6720             


Glu Lys  Ser Leu Asp Ser Glu  Leu Glu Ile Ala Asn  Asp Pro Asp 
    6725                 6730                 6735             


Lys Ile  Lys Thr Gln Leu Ala  Gln His Lys Glu Phe  Gln Lys Ser 
    6740                 6745                 6750             


Leu Gly  Ala Lys His Ser Val  Tyr Asp Thr Thr Asn  Arg Thr Gly 
    6755                 6760                 6765             


Arg Ser  Leu Lys Glu Lys Thr  Ser Leu Ala Asp Asp  Asn Leu Lys 
    6770                 6775                 6780             


Leu Asp  Asp Met Leu Ser Glu  Leu Arg Asp Lys Trp  Asp Thr Ile 
    6785                 6790                 6795             


Cys Gly  Lys Ser Val Glu Arg  Gln Asn Lys Leu Glu  Glu Ala Leu 
    6800                 6805                 6810             


Leu Phe  Ser Gly Gln Phe Thr  Asp Ala Leu Gln Ala  Leu Ile Asp 
    6815                 6820                 6825             


Trp Leu  Tyr Arg Val Glu Pro  Gln Leu Ala Glu Asp  Gln Pro Val 
    6830                 6835                 6840             


His Gly  Asp Ile Asp Leu Val  Met Asn Leu Ile Asp  Asn His Lys 
    6845                 6850                 6855             


Ala Phe  Gln Lys Glu Leu Gly  Lys Arg Thr Ser Ser  Val Gln Ala 
    6860                 6865                 6870             


Leu Lys  Arg Ser Ala Arg Glu  Leu Ile Glu Gly Ser  Arg Asp Asp 
    6875                 6880                 6885             


Ser Ser  Trp Val Lys Val Gln  Met Gln Glu Leu Ser  Thr Arg Trp 
    6890                 6895                 6900             


Glu Thr  Val Cys Ala Leu Ser  Ile Ser Lys Gln Thr  Arg Leu Glu 
    6905                 6910                 6915             


Ala Ala  Leu Arg Gln Ala Glu  Glu Phe His Ser Val  Val His Ala 
    6920                 6925                 6930             


Leu Leu  Glu Trp Leu Ala Glu  Ala Glu Gln Thr Leu  Arg Phe His 
    6935                 6940                 6945             


Gly Val  Leu Pro Asp Asp Glu  Asp Ala Leu Arg Thr  Leu Ile Asp 
    6950                 6955                 6960             


Gln His  Lys Glu Phe Met Lys  Lys Leu Glu Glu Lys  Arg Ala Glu 
    6965                 6970                 6975             


Leu Asn  Lys Ala Thr Thr Met  Gly Asp Thr Val Leu  Ala Ile Cys 
    6980                 6985                 6990             


His Pro  Asp Ser Ile Thr Thr  Ile Lys His Trp Ile  Thr Ile Ile 
    6995                 7000                 7005             


Arg Ala  Arg Phe Glu Glu Val  Leu Ala Trp Ala Lys  Gln His Gln 
    7010                 7015                 7020             


Gln Arg  Leu Ala Ser Ala Leu  Ala Gly Leu Ile Ala  Lys Gln Glu 
    7025                 7030                 7035             


Leu Leu  Glu Ala Leu Leu Ala  Trp Leu Gln Trp Ala  Glu Thr Thr 
    7040                 7045                 7050             


Leu Thr  Asp Lys Asp Lys Glu  Val Ile Pro Gln Glu  Ile Glu Glu 
    7055                 7060                 7065             


Val Lys  Ala Leu Ile Ala Glu  His Gln Thr Phe Met  Glu Glu Met 
    7070                 7075                 7080             


Thr Arg  Lys Gln Pro Asp Val  Asp Lys Val Thr Lys  Thr Tyr Lys 
    7085                 7090                 7095             


Arg Arg  Ala Ala Asp Pro Ser  Ser Leu Gln Ser His  Ile Pro Val 
    7100                 7105                 7110             


Leu Asp  Lys Gly Arg Ala Gly  Arg Lys Arg Phe Pro  Ala Ser Ser 
    7115                 7120                 7125             


Leu Tyr  Pro Ser Gly Ser Gln  Thr Gln Ile Glu Thr  Lys Asn Pro 
    7130                 7135                 7140             


Arg Val  Asn Leu Leu Val Ser  Lys Trp Gln Gln Val  Trp Leu Leu 
    7145                 7150                 7155             


Ala Leu  Glu Arg Arg Arg Lys  Leu Asn Asp Ala Leu  Asp Arg Leu 
    7160                 7165                 7170             


Glu Glu  Leu Arg Glu Phe Ala  Asn Phe Asp Phe Asp  Ile Trp Arg 
    7175                 7180                 7185             


Lys Lys  Tyr Met Arg Trp Met  Asn His Lys Lys Ser  Arg Val Met 
    7190                 7195                 7200             


Asp Phe  Phe Arg Arg Ile Asp  Lys Asp Gln Asp Gly  Lys Ile Thr 
    7205                 7210                 7215             


Arg Gln  Glu Phe Ile Asp Gly  Ile Leu Ser Ser Lys  Phe Pro Thr 
    7220                 7225                 7230             


Ser Arg  Leu Glu Met Ser Ala  Val Ala Asp Ile Phe  Asp Arg Asp 
    7235                 7240                 7245             


Gly Asp  Gly Tyr Ile Asp Tyr  Tyr Glu Phe Val Ala  Ala Leu His 
    7250                 7255                 7260             


Pro Asn  Lys Asp Ala Tyr Lys  Pro Ile Thr Asp Ala  Asp Lys Ile 
    7265                 7270                 7275             


Glu Asp  Glu Val Thr Arg Gln  Val Ala Lys Cys Lys  Cys Ala Lys 
    7280                 7285                 7290             


Arg Phe  Gln Val Glu Gln Ile  Gly Asp Asn Lys Tyr  Arg Phe Phe 
    7295                 7300                 7305             


Leu Gly  Asn Gln Phe Gly Asp  Ser Gln Gln Leu Arg  Leu Val Arg 
    7310                 7315                 7320             


Ile Leu  Arg Ser Thr Val Met  Val Arg Val Gly Gly  Gly Trp Met 
    7325                 7330                 7335             


Ala Leu  Asp Glu Phe Leu Val  Lys Asn Asp Pro Cys  Arg Val His 
    7340                 7345                 7350             


His His  Gly Ser Lys Met Leu  Arg Ser Glu Ser Asn  Ser Ser Ile 
    7355                 7360                 7365             


Thr Thr  Thr Gln Pro Thr Ile  Ala Lys Gly Arg Thr  Asn Met Glu 
    7370                 7375                 7380             


Leu Arg  Glu Lys Phe Ile Leu  Ala Asp Gly Ala Ser  Gln Gly Met 
    7385                 7390                 7395             


Ala Ala  Phe Arg Pro Arg Gly  Arg Arg Ser Arg Pro  Ser Ser Arg 
    7400                 7405                 7410             


Gly Ala  Ser Pro Asn Arg Ser  Thr Ser Val Ser Ser  Gln Ala Ala 
    7415                 7420                 7425             


Gln Ala  Ala Ser Pro Gln Val  Pro Ala Thr Thr Thr  Pro Lys Gly 
    7430                 7435                 7440             


Thr Pro  Ile Gln Gly Ser Lys  Leu Arg Leu Pro Gly  Tyr Leu Ser 
    7445                 7450                 7455             


Gly Lys  Gly Phe His Ser Gly  Glu Asp Ser Gly Leu  Ile Thr Thr 
    7460                 7465                 7470             


Ala Ala  Ala Arg Val Arg Thr  Gln Phe Ala Asp Ser  Lys Lys Thr 
    7475                 7480                 7485             


Pro Ser  Arg Pro Gly Ser Arg  Ala Gly Ser Lys Ala  Gly Ser Arg 
    7490                 7495                 7500             


Ala Ser  Ser Arg Arg Gly Ser  Asp Ala Ser Asp Phe  Asp Ile Ser 
    7505                 7510                 7515             


Glu Ile  Gln Ser Val Cys Ser  Asp Val Glu Thr Val  Pro Gln Thr 
    7520                 7525                 7530             


His Arg  Pro Thr Pro Arg Ala  Gly Ser Arg Pro Ser  Thr Ala Lys 
    7535                 7540                 7545             


Pro Ser  Lys Ile Pro Thr Pro  Gln Arg Lys Ser Pro  Ala Ser Lys 
    7550                 7555                 7560             


Leu Asp  Lys Ser Ser Lys Arg  
    7565                 7570 


<210>  3
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Gly Arg Val Gln Leu Ile Lys Ala Leu Leu Ala Leu Pro Ile 
1               5                   10                  15      


Arg Pro Ala Thr Arg Arg Trp Arg Asn Pro Ile Pro Phe Pro Glu Thr 
            20                  25                  30          


Phe Asp Gly Asp Thr Asp Arg Leu Pro Glu Phe Ile Val Gln Thr Gly 
        35                  40                  45              


Ser Tyr Met Phe Val Asp Glu Asn Thr Phe Ser Ser Asp Ala Leu Lys 
    50                  55                  60                  


Val Thr Phe Leu Ile Thr Arg Leu Thr Gly Pro Ala Leu Gln Trp Val 
65                  70                  75                  80  


Ile Pro Tyr Ile Lys Lys Glu Ser Pro Leu Leu Asn Asp Tyr Arg Gly 
                85                  90                  95      


Phe Leu Ala Glu Met Lys Arg Val Phe Gly Trp Glu Glu Asp Glu Asp 
            100                 105                 110         


Phe 
    


<210>  4
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Gly Arg Val Gln Leu Met Lys Ala Leu Leu Ala Gly Pro Leu 
1               5                   10                  15      


Arg Pro Ala Ala Arg Arg Trp Arg Asn Pro Ile Pro Phe Pro Glu Thr 
            20                  25                  30          


Phe Asp Gly Asp Thr Asp Arg Leu Pro Glu Phe Ile Val Gln Thr Ser 
        35                  40                  45              


Ser Tyr Met Phe Val Asp Glu Asn Thr Phe Ser Asn Asp Ala Leu Lys 
    50                  55                  60                  


Val Thr Phe Leu Ile Thr Arg Leu Thr Gly Pro Ala Leu Gln Trp Val 
65                  70                  75                  80  


Ile Pro Tyr Ile Arg Lys Glu Ser Pro Leu Leu Asn Asp Tyr Arg Gly 
                85                  90                  95      


Phe Leu Ala Glu Met Lys Arg Val Phe Gly Trp Glu Glu Asp Glu Asp 
            100                 105                 110         


Phe 
    


<210>  5
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Gly Arg Val Gln Leu Met Lys Ala Leu Leu Ala Arg Pro Leu 
1               5                   10                  15      


Arg Pro Ala Ala Arg Arg Trp Arg Asn Pro Ile Pro Phe Pro Glu Thr 
            20                  25                  30          


Phe Asp Gly Asp Thr Asp Arg Leu Pro Glu Phe Ile Val Gln Thr Ser 
        35                  40                  45              


Ser Tyr Met Phe Val Asp Glu Asn Thr Phe Ser Asn Asp Ala Leu Lys 
    50                  55                  60                  


Val Thr Phe Leu Ile Thr Arg Leu Thr Gly Pro Ala Leu Gln Trp Val 
65                  70                  75                  80  


Ile Pro Tyr Ile Lys Lys Glu Ser Pro Leu Leu Ser Asp Tyr Arg Gly 
                85                  90                  95      


Phe Leu Ala Glu Met Lys Arg Val Phe Gly Trp Glu Glu Asp Glu Asp 
            100                 105                 110         


Phe 
    


<210>  6
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Glu Arg Arg Arg Asp Glu Leu Ser Glu Glu Ile Asn Asn Leu 
1               5                   10                  15      


Arg Glu Lys Val Met Lys Gln Ser Glu Glu Asn Asn Asn Leu Gln Ser 
            20                  25                  30          


Gln Val Gln Lys Leu Thr Glu Glu Asn Thr Thr Leu Arg Glu Gln Val 
        35                  40                  45              


Glu Pro Thr Pro Glu Asp Glu Asp Asp Asp Ile Glu Leu Arg Gly Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Pro Pro Pro Pro Ile Glu Glu Glu Cys Pro Glu 
65                  70                  75                  80  


Asp Leu Pro Glu Lys Phe Asp Gly Asn Pro Asp Met Leu Ala Pro Phe 
                85                  90                  95      


Met Ala Gln Cys Gln Ile Phe Met Glu Lys Ser Thr Arg Asp Phe Ser 
            100                 105                 110         


Val Asp Arg Val Arg Val Cys Phe Val Thr Ser Met Met Thr Gly Arg 
        115                 120                 125             


Ala Ala Arg Trp Ala Ser Ala Lys Leu Glu Arg Ser His Tyr Leu Met 
    130                 135                 140                 


His Asn Tyr Pro Ala Phe Met Met Glu Met Lys His Val Phe Glu Asp 
145                 150                 155                 160 


Pro Gln Arg Arg Glu Val Ala Lys Arg Lys Ile Arg Arg Leu Arg Gln 
                165                 170                 175     


Gly Met Gly Ser Val Ile Asp Tyr Ser Asn Ala Phe Gln Met Ile Ala 
            180                 185                 190         


Gln Asp Leu Asp Trp Asn Glu Pro Ala Leu Ile Asp Gln Tyr His Glu 
        195                 200                 205             


Gly Leu Ser Asp His Ile Gln Glu Glu Leu Ser His Leu Glu Val Ala 
    210                 215                 220                 


Lys Ser Leu Ser Ala Leu Ile Gly Gln Cys Ile His Ile Glu Arg Arg 
225                 230                 235                 240 


Leu Ala Arg Ala Ala Ala Ala Arg Lys Pro Arg Ser Pro Pro Arg Ala 
                245                 250                 255     


Leu Val Leu Pro His Ile Ala Ser His His Gln Val Asp Pro Thr Glu 
            260                 265                 270         


Pro Val Gly Gly Ala Arg Met Arg Leu Thr Gln Glu Glu Lys Glu Arg 
        275                 280                 285             


Arg Arg Lys Leu Asn Leu Cys Leu Tyr Cys Gly Thr Gly Gly His Tyr 
    290                 295                 300                 


Ala Asp Asn Cys Pro Ala Lys Ala Ser Lys Ser Ser Pro Ala Gly Lys 
305                 310                 315                 320 


Leu Pro Gly Pro Ala Val Glu Gly Pro Ser Ala Thr Gly Pro Glu Ile 
                325                 330                 335     


Ile Arg Ser Pro Gln Asp Asp Ala Ser Ser Pro His Leu Gln Val Met 
            340                 345                 350         


Leu Gln Ile His Leu Pro Gly Arg His Thr Leu Phe Val Arg Ala Met 
        355                 360                 365             


Ile Asp Ser Gly Ala Ser Gly Asn Phe Ile Asp His Glu Tyr Val Ala 
    370                 375                 380                 


Gln Asn Gly Ile Pro Leu Arg Ile Lys Asp Trp Pro Ile Leu Val Glu 
385                 390                 395                 400 


Ala Ile Asp Gly Arg Pro Ile Ala Ser Gly Pro Val Val His Glu Thr 
                405                 410                 415     


His Asp Leu Ile Val Asp Leu Gly Asp His Arg Glu Val Leu Ser Phe 
            420                 425                 430         


Asp Val Thr Gln Ser Pro Phe Phe Pro Val Val Leu Gly Val Arg Trp 
        435                 440                 445             


Leu Ser Thr His Asp Pro Asn Ile Thr Trp Ser Thr Arg Ser Ile Val 
    450                 455                 460                 


Phe Asp Ser Glu Tyr Cys Arg Tyr His Cys Arg Met Tyr Ser Pro Ile 
465                 470                 475                 480 


Pro Pro Ser Leu Pro Pro Pro Ala Pro Gln Pro Pro Leu Tyr Tyr Pro 
                485                 490                 495     


Val Asp Gly Tyr Arg Val Tyr Gln Pro Val Arg Tyr Tyr Tyr Val Gln 
            500                 505                 510         


Asn Val Tyr Thr Pro Val Asp Glu His Val Tyr Pro Asp His Arg Leu 
        515                 520                 525             


Val Asp Pro His Ile Glu Met Ile Pro Gly Ala His Ser Ile Pro Ser 
    530                 535                 540                 


Gly His Val Tyr Ser Leu Ser Glu Pro Glu Met Ala Ala Leu Arg Asp 
545                 550                 555                 560 


Phe Val Ala Arg Asn Val Lys Asp Gly Leu Ile Thr Pro Thr Ile Ala 
                565                 570                 575     


Pro Asn Gly Ala Gln Val Leu Gln Val Lys Arg Gly Trp Lys Leu Gln 
            580                 585                 590         


Val Ser Tyr Asp Cys Arg Ala Pro Asn Asn Phe Thr Ile Gln Asn Gln 
        595                 600                 605             


Tyr Pro Arg Leu Ser Ile Pro Asn Leu Glu Asp Gln Ala His Leu Ala 
    610                 615                 620                 


Thr Tyr Thr Glu Phe Val Pro Gln Ile Pro Gly Tyr Gln Thr Tyr Pro 
625                 630                 635                 640 


Thr Tyr Ala Ala Tyr Pro Thr Tyr Pro Val Gly Phe Ala Trp Tyr Pro 
                645                 650                 655     


Val Gly Arg Asp Gly Gln Gly Arg Ser Leu Tyr Val Pro Val Met Ile 
            660                 665                 670         


Thr Trp Asn Pro His Trp Tyr Arg Gln Pro Pro Val Pro Gln Tyr Pro 
        675                 680                 685             


Pro Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ser 
    690                 695                 700                 


Tyr Ser Thr Leu 
705             


<210>  7
<211>  921
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Thr Pro Ser Ala Ala Phe Glu Ala Leu Met Asn Gly Val Thr 
1               5                   10                  15      


Ser Trp Asp Val Pro Glu Asp Ala Val Pro Cys Glu Leu Leu Leu Ile 
            20                  25                  30          


Gly Glu Ala Ser Phe Pro Val Met Val Asn Asp Met Gly Gln Val Leu 
        35                  40                  45              


Ile Ala Ala Ser Ser Tyr Gly Arg Gly Arg Leu Val Val Val Ser His 
    50                  55                  60                  


Glu Asp Tyr Leu Val Glu Ala Gln Leu Thr Pro Phe Leu Leu Asn Ala 
65                  70                  75                  80  


Val Gly Trp Leu Cys Ser Ser Pro Gly Ala Pro Ile Gly Val His Pro 
                85                  90                  95      


Ser Leu Ala Pro Leu Ala Lys Ile Leu Glu Gly Ser Gly Val Asp Ala 
            100                 105                 110         


Lys Val Glu Pro Glu Val Lys Asp Ser Leu Gly Val Tyr Cys Ile Asp 
        115                 120                 125             


Ala Tyr Asn Glu Thr Met Thr Glu Lys Leu Val Lys Phe Met Lys Cys 
    130                 135                 140                 


Gly Gly Gly Leu Leu Ile Gly Gly Gln Ala Trp Asp Trp Ala Asn Gln 
145                 150                 155                 160 


Gly Glu Asp Glu Arg Val Leu Phe Thr Phe Pro Gly Asn Leu Val Thr 
                165                 170                 175     


Ser Val Ala Gly Ile Tyr Phe Thr Asp Asn Lys Gly Asp Thr Ser Phe 
            180                 185                 190         


Phe Lys Val Ser Lys Lys Met Pro Lys Ile Pro Val Leu Val Ser Cys 
        195                 200                 205             


Glu Asp Asp Leu Ser Asp Asp Arg Glu Glu Leu Leu His Gly Ile Ser 
    210                 215                 220                 


Glu Leu Asp Ile Ser Asn Ser Asp Cys Phe Pro Ser Gln Leu Leu Val 
225                 230                 235                 240 


His Gly Ala Leu Ala Phe Pro Leu Gly Leu Asp Ser Tyr His Gly Cys 
                245                 250                 255     


Val Ile Ala Ala Ala Arg Tyr Gly Arg Gly Arg Val Val Val Thr Gly 
            260                 265                 270         


His Lys Val Leu Phe Thr Val Gly Lys Leu Gly Pro Phe Leu Leu Asn 
        275                 280                 285             


Ala Val Arg Trp Leu Asp Gly Gly Arg Arg Gly Lys Val Val Val Gln 
    290                 295                 300                 


Thr Glu Leu Arg Thr Leu Ser Gly Leu Leu Ala Val Gly Gly Ile Asp 
305                 310                 315                 320 


Thr Ser Ile Glu Pro Asn Leu Thr Ser Asp Ala Ser Val Tyr Cys Phe 
                325                 330                 335     


Glu Pro Val Ser Glu Val Gly Val Lys Glu Leu Gln Glu Phe Val Ala 
            340                 345                 350         


Glu Gly Gly Gly Leu Phe Val Gly Ala Gln Ala Trp Trp Trp Ala Phe 
        355                 360                 365             


Lys Asn Pro Gly Val Ser Pro Leu Ala Arg Phe Pro Gly Asn Leu Leu 
    370                 375                 380                 


Leu Asn Pro Phe Gly Ile Ser Ile Thr Ser Gln Ser Leu Asn Pro Gly 
385                 390                 395                 400 


Pro Phe Arg Thr Pro Lys Ala Gly Ile Arg Thr Tyr His Phe Arg Ser 
                405                 410                 415     


Thr Leu Ala Glu Phe Gln Val Ile Met Gly Arg Lys Arg Gly Asn Val 
            420                 425                 430         


Glu Lys Gly Trp Leu Ala Lys Leu Gly Pro Asp Gly Ala Ala Phe Leu 
        435                 440                 445             


Gln Ile Pro Ala Glu Glu Ile Pro Ala Tyr Met Ser Val His Arg Leu 
    450                 455                 460                 


Leu Arg Lys Leu Leu Ser Arg Tyr Arg Leu Pro Val Ala Thr Arg Glu 
465                 470                 475                 480 


Asn Pro Val Ile Asn Asp Cys Cys Arg Gly Ala Met Leu Ser Leu Ala 
                485                 490                 495     


Thr Gly Leu Ala His Ser Gly Ser Asp Leu Ser Leu Leu Val Pro Glu 
            500                 505                 510         


Ile Glu Asp Met Tyr Ser Ser Pro Tyr Leu Arg Pro Ser Glu Ser Pro 
        515                 520                 525             


Ile Thr Val Glu Val Asn Cys Thr Asn Pro Gly Thr Arg Tyr Cys Trp 
    530                 535                 540                 


Met Ser Thr Gly Leu Tyr Ile Pro Gly Arg Gln Ile Ile Glu Val Ser 
545                 550                 555                 560 


Leu Pro Glu Ala Ala Ala Ser Ala Asp Leu Lys Ile Gln Ile Gly Cys 
                565                 570                 575     


His Thr Asp Asp Leu Thr Arg Ala Ser Lys Leu Phe Arg Gly Pro Leu 
            580                 585                 590         


Val Ile Asn Arg Cys Cys Leu Asp Lys Pro Thr Lys Ser Ile Thr Cys 
        595                 600                 605             


Leu Trp Gly Gly Leu Leu Tyr Ile Ile Val Pro Gln Asn Ser Lys Leu 
    610                 615                 620                 


Gly Ser Val Pro Val Thr Val Lys Gly Ala Val His Ala Pro Tyr Tyr 
625                 630                 635                 640 


Lys Leu Gly Glu Thr Thr Leu Glu Glu Trp Lys Arg Arg Ile Gln Glu 
                645                 650                 655     


Asn Pro Gly Pro Trp Gly Glu Leu Ala Thr Asp Asn Ile Ile Leu Thr 
            660                 665                 670         


Val Pro Thr Ala Asn Leu Arg Thr Leu Glu Asn Pro Glu Pro Leu Leu 
        675                 680                 685             


Arg Leu Trp Asp Glu Val Met Gln Ala Val Ala Arg Leu Gly Ala Glu 
    690                 695                 700                 


Pro Phe Pro Leu Arg Leu Pro Gln Arg Ile Val Ala Asp Val Gln Ile 
705                 710                 715                 720 


Ser Val Gly Trp Met His Ala Gly Tyr Pro Ile Met Cys His Leu Glu 
                725                 730                 735     


Ser Val Gln Glu Leu Ile Asn Glu Lys Leu Ile Arg Thr Lys Gly Leu 
            740                 745                 750         


Trp Gly Pro Val His Glu Leu Gly Arg Asn Gln Gln Arg Gln Glu Trp 
        755                 760                 765             


Glu Phe Pro Pro His Thr Thr Glu Ala Thr Cys Asn Leu Trp Cys Val 
    770                 775                 780                 


Tyr Val His Glu Thr Val Leu Gly Ile Pro Arg Ser Arg Ala Asn Ile 
785                 790                 795                 800 


Ala Leu Trp Pro Pro Val Arg Glu Lys Arg Val Arg Ile Tyr Leu Ser 
                805                 810                 815     


Lys Gly Pro Asn Val Lys Asn Trp Asn Ala Trp Thr Ala Leu Glu Thr 
            820                 825                 830         


Tyr Leu Gln Leu Gln Glu Ala Phe Gly Trp Glu Pro Phe Ile Arg Leu 
        835                 840                 845             


Phe Thr Glu Tyr Arg Asn Gln Thr Asn Leu Pro Thr Glu Asn Val Asp 
    850                 855                 860                 


Lys Met Asn Leu Trp Val Lys Met Phe Ser His Gln Val Gln Lys Asn 
865                 870                 875                 880 


Leu Ala Pro Phe Phe Glu Ala Trp Ala Trp Pro Ile Gln Lys Glu Val 
                885                 890                 895     


Ala Thr Ser Leu Ala Tyr Leu Pro Glu Trp Lys Glu Asn Ile Met Lys 
            900                 905                 910         


Leu Tyr Leu Leu Thr Gln Met Pro His 
        915                 920     


<210>  8
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser His Pro Ser Pro Gln Ala Lys Pro Ser Asn Pro Ser Asn Pro 
1               5                   10                  15      


Arg Val Phe Phe Asp Val Asp Ile Gly Gly Glu Arg Val Gly Arg Ile 
            20                  25                  30          


Val Leu Glu Leu Phe Ala Asp Ile Val Pro Lys Thr Ala Glu Asn Phe 
        35                  40                  45              


Arg Ala Leu Cys Thr Gly Glu Lys Gly Ile Gly His Thr Thr Gly Lys 
    50                  55                  60                  


Pro Leu His Phe Lys Gly Cys Pro Phe His Arg Ile Ile Lys Lys Phe 
65                  70                  75                  80  


Met Ile Gln Gly Gly Asp Phe Ser Asn Gln Asn Gly Thr Gly Gly Glu 
                85                  90                  95      


Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe His Tyr Lys His 
            100                 105                 110         


Asp Arg Glu Gly Leu Leu Ser Met Ala Asn Ala Gly Arg Asn Thr Asn 
        115                 120                 125             


Gly Ser Gln Phe Phe Ile Thr Thr Val Pro Thr Pro His Leu Asp Gly 
    130                 135                 140                 


Lys His Val Val Phe Gly Gln Val Ile Lys Gly Ile Gly Val Ala Arg 
145                 150                 155                 160 


Ile Leu Glu Asn Val Glu Val Lys Gly Glu Lys Pro Ala Lys Leu Cys 
                165                 170                 175     


Val Ile Ala Glu Cys Gly Glu Leu Lys Glu Gly Asp Asp Gly Gly Ile 
            180                 185                 190         


Phe Pro Lys Asp Gly Ser Gly Asp Ser His Pro Asp Phe Pro Glu Asp 
        195                 200                 205             


Ala Asp Ile Asp Leu Lys Asp Val Asp Lys Ile Leu Leu Ile Thr Glu 
    210                 215                 220                 


Asp Leu Lys Asn Ile Gly Asn Thr Phe Phe Lys Ser Gln Asn Trp Glu 
225                 230                 235                 240 


Met Ala Ile Lys Lys Tyr Ala Glu Val Leu Arg Tyr Val Asp Ser Ser 
                245                 250                 255     


Lys Ala Val Ile Glu Thr Ala Asp Arg Ala Lys Leu Gln Pro Ile Ala 
            260                 265                 270         


Leu Ser Cys Val Leu Asn Ile Gly Ala Cys Lys Leu Lys Met Ser Asn 
        275                 280                 285             


Trp Gln Gly Ala Ile Asp Ser Cys Leu Glu Ala Leu Glu Leu Asp Pro 
    290                 295                 300                 


Ser Asn Thr Lys Ala Leu Tyr Arg Arg Ala Gln Gly Trp Gln Gly Leu 
305                 310                 315                 320 


Lys Glu Tyr Asp Gln Ala Leu Ala Asp Leu Lys Lys Ala Gln Gly Ile 
                325                 330                 335     


Ala Pro Glu Asp Lys Ala Ile Gln Ala Glu Leu Leu Lys Val Lys Gln 
            340                 345                 350         


Lys Ile Lys Ala Gln Lys Asp Lys Glu Lys Ala Val Tyr Ala Lys Met 
        355                 360                 365             


Phe Ala 
    370 


<210>  9
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys 
1               5                   10      


<210>  10
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  10

Trp Gln Pro Gly Glu Glu Pro Ala Gly Ser Val Val Gln Asp Ser Arg 
1               5                   10                  15      


<210>  11
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Phe Ser Gln Ser Phe Asp Ala Ala Met Lys 
1               5                   10      


<210>  12
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  12

Thr Leu Glu Asn Pro Glu Pro Leu Leu Arg 
1               5                   10  


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Gly Ala Glu Pro Phe Pro Leu Arg 
1               5                   


<210>  14
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Val Ala Thr Ser Leu Ala Tyr Leu Pro Glu Trp Lys 
1               5                   10              


<210>  15
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  15

His Val Val Phe Gly Gln Val Ile Lys 
1               5                   


<210>  16
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  16

Asn Ile Gly Asn Thr Phe Phe Lys 
1               5               


<210>  17
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  17

Thr Ala Ile Glu Ser Phe Ala Leu Met Val Lys 
1               5                   10      


<210>  18
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Asp Phe Gln Ile Tyr Glu Lys 
1               5                   


<210>  19
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Glu Val Tyr Ile Val Gln Ala Pro Thr Pro Glu Ile Lys 
1               5                   10                  


<210>  20
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  20

Ile Asn Glu Pro Gly Gln Ser Ala Val Phe Cys Gly Arg 
1               5                   10              


<210>  21
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  21

Phe Thr Val Tyr Pro Ile Met Pro Ala Ala Gly Pro Lys 
1               5                   10              


<210>  22
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Asn Thr Ala Tyr Phe Glu Phe Phe Asn Asp Ala Lys 
1               5                   10              


<210>  23
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  23

Val Leu Gln Glu Asp Ile Leu Leu Arg 
1               5                   


<210>  24
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  24

Ser Glu Ala Tyr Gln Gln Gln Ile Glu Met Glu Arg 
1               5                   10          


<210>  25
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Val Ile Pro Gln Glu Ile Glu Glu Val Lys 
1               5                   10      


<210>  26
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  26

Val Gly Gly Gly Trp Met Ala Leu Asp Glu Phe Leu Val Lys 
1               5                   10                  


<210>  27
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  27

Ser Leu Gly His Glu Val Asn Glu Leu Thr Ser Ser Arg 
1               5                   10              


<210>  28
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  28

Ser Leu Glu Gln Glu Thr Ser Gln Leu Glu Lys 
1               5                   10      


<210>  29
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Ser Ser Val Ile Ser Thr Ala Glu Gly Thr Thr Arg 
1               5                   10              


<210>  30
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  30

Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg 
1               5                   10  


<210>  31
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Ile Thr Ala Leu Ala Pro Ser Thr Met Lys 
1               5                   10      


<210>  32
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  32

Glu Gln Val Glu Pro Thr Pro Glu Asp Glu Asp Asp Asp Ile Glu Leu 
1               5                   10                  15      


Arg 
    


<210>  33
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  33

Trp Leu Ser Thr His Asp Pro Asn Ile Thr Trp Ser Thr Arg 
1               5                   10                  


<210>  34
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  34

Ser Ile Val Phe Asp Ser Glu Tyr Cys Arg 
1               5                   10  


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UBE3A sense LNA

<400>  35
tttacaccta cttcttaaca                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense LNA

<400>  36
ctttccattt atttccattt                                                   20


