                         SEQUENCE LISTING

<110>  UNIVERSITY OF VIRGINIA PATENT FOUNDATION
       Noth, Imre
 
<120>  COMPOSITIONS AND METHODS FOR PREDICTING LUNG FUNCTION DECLINE IN 
       IDIOPATHIC PULMONARY FIBROSIS

<130>  3062/50 PCT

<150>  US 62/791,083
<151>  2019-01-11

<150>  US 62/849,630
<151>  2019-05-17

<160>  66    

<170>  PatentIn version 3.5

<210>  1
<211>  3139
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (33)..(1724)

<400>  1
gatccagcga acagccccgc ttctaacccg ag atg ctg ctg ccg gcg ccc gcg         53
                                    Met Leu Leu Pro Ala Pro Ala           
                                    1               5                     

ctc cgc cgc gcc ctg ctg tcc cgc ccc tgg acc ggg gcc ggc ctg cgg        101
Leu Arg Arg Ala Leu Leu Ser Arg Pro Trp Thr Gly Ala Gly Leu Arg           
        10                  15                  20                        

tgg aag cac acc tcc tcc ctg aag gtg gcc aac gag ccc gtc tta gcc        149
Trp Lys His Thr Ser Ser Leu Lys Val Ala Asn Glu Pro Val Leu Ala           
    25                  30                  35                            

ttc acg cag ggc agc cct gag cga gat gcc ctg caa aag gcc ttg aag        197
Phe Thr Gln Gly Ser Pro Glu Arg Asp Ala Leu Gln Lys Ala Leu Lys           
40                  45                  50                  55            

gac ctg aag ggc cgg atg gaa gcc atc cca tgc gtg gtg ggg gat gag        245
Asp Leu Lys Gly Arg Met Glu Ala Ile Pro Cys Val Val Gly Asp Glu           
                60                  65                  70                

gag gtg tgg acg tcg gac gtg cag tac caa gtg tcg cct ttt aac cat        293
Glu Val Trp Thr Ser Asp Val Gln Tyr Gln Val Ser Pro Phe Asn His           
            75                  80                  85                    

gga cat aag gtg gcc aag ttc tgt tat gca gac aag agc ctg ctc aac        341
Gly His Lys Val Ala Lys Phe Cys Tyr Ala Asp Lys Ser Leu Leu Asn           
        90                  95                  100                       

aaa gcc att gag gct gcc ctg gct gcc cgg aaa gag tgg gac ctg aag        389
Lys Ala Ile Glu Ala Ala Leu Ala Ala Arg Lys Glu Trp Asp Leu Lys           
    105                 110                 115                           

cct att gca gac cgg gcc cag atc ttc ctg aag gcg gca gac atg ctg        437
Pro Ile Ala Asp Arg Ala Gln Ile Phe Leu Lys Ala Ala Asp Met Leu           
120                 125                 130                 135           

agt ggg ccg cgc agg gct gag atc ctc gcc aag acc atg gtg gga cag        485
Ser Gly Pro Arg Arg Ala Glu Ile Leu Ala Lys Thr Met Val Gly Gln           
                140                 145                 150               

ggt aag acc gtg atc caa gcg gag att gac gct gca gcg gaa ctc atc        533
Gly Lys Thr Val Ile Gln Ala Glu Ile Asp Ala Ala Ala Glu Leu Ile           
            155                 160                 165                   

gac ttc ttc cgg ttc aat gcc aag tat gcg gtg gag ctg gag ggg cag        581
Asp Phe Phe Arg Phe Asn Ala Lys Tyr Ala Val Glu Leu Glu Gly Gln           
        170                 175                 180                       

cag ccc atc agc gtg ccc ccg agc acc aac agc acg gtg tac cgg ggt        629
Gln Pro Ile Ser Val Pro Pro Ser Thr Asn Ser Thr Val Tyr Arg Gly           
    185                 190                 195                           

ctg gag ggc ttc gtg gcg gcc atc tcg ccc ttt aac ttc act gca atc        677
Leu Glu Gly Phe Val Ala Ala Ile Ser Pro Phe Asn Phe Thr Ala Ile           
200                 205                 210                 215           

ggc ggc aac ctg gcg ggg gca ccg gcc ctg atg ggc aac gtg gtc cta        725
Gly Gly Asn Leu Ala Gly Ala Pro Ala Leu Met Gly Asn Val Val Leu           
                220                 225                 230               

tgg aag ccc agt gac act gcc atg ctg gcc agc tat gct gtc tac cgc        773
Trp Lys Pro Ser Asp Thr Ala Met Leu Ala Ser Tyr Ala Val Tyr Arg           
            235                 240                 245                   

atc ctt cgg gag gct ggc ctg ccc ccc aac atc atc cag ttt gtg cca        821
Ile Leu Arg Glu Ala Gly Leu Pro Pro Asn Ile Ile Gln Phe Val Pro           
        250                 255                 260                       

gct gat ggg ccc cta ttt ggg gac act gtc acc agc tca gag cac ctc        869
Ala Asp Gly Pro Leu Phe Gly Asp Thr Val Thr Ser Ser Glu His Leu           
    265                 270                 275                           

tgt ggc atc aac ttc aca ggc agt gtg ccc acc ttc aaa cac ctg tgg        917
Cys Gly Ile Asn Phe Thr Gly Ser Val Pro Thr Phe Lys His Leu Trp           
280                 285                 290                 295           

aag cag gtg gcc cag aac ctg gac cgg ttc cac acc ttc cca cgc ctg        965
Lys Gln Val Ala Gln Asn Leu Asp Arg Phe His Thr Phe Pro Arg Leu           
                300                 305                 310               

gct gga gag tgc ggc gga aag aac ttc cac ttc gtg cac cgc tcg gcc       1013
Ala Gly Glu Cys Gly Gly Lys Asn Phe His Phe Val His Arg Ser Ala           
            315                 320                 325                   

gac gtg gag agc gtg gtg agc ggg acc ctc cgc tca gcc ttc gag tac       1061
Asp Val Glu Ser Val Val Ser Gly Thr Leu Arg Ser Ala Phe Glu Tyr           
        330                 335                 340                       

ggt ggc cag aag tgt tcc gcg tgc tcg cgt ctc tac gtg ccg cac tcg       1109
Gly Gly Gln Lys Cys Ser Ala Cys Ser Arg Leu Tyr Val Pro His Ser           
    345                 350                 355                           

ctg tgg ccg cag atc aaa ggg cgg ctg ctg gag gag cac agt cgg atc       1157
Leu Trp Pro Gln Ile Lys Gly Arg Leu Leu Glu Glu His Ser Arg Ile           
360                 365                 370                 375           

aaa gtg ggc gac cct gca gag gat ttt ggg acc ttc ttc tct gca gtg       1205
Lys Val Gly Asp Pro Ala Glu Asp Phe Gly Thr Phe Phe Ser Ala Val           
                380                 385                 390               

att gat gcc aag tcc ttt gcc cgt atc aag aag tgg ctg gag cac gca       1253
Ile Asp Ala Lys Ser Phe Ala Arg Ile Lys Lys Trp Leu Glu His Ala           
            395                 400                 405                   

cgc tcc tca ccc agc ctc acc atc ctg gcc ggg ggc aag tgt gat gac       1301
Arg Ser Ser Pro Ser Leu Thr Ile Leu Ala Gly Gly Lys Cys Asp Asp           
        410                 415                 420                       

tcc gtg ggc tac ttt gtg gag ccc tgc atc gtg gag agc aag gac cct       1349
Ser Val Gly Tyr Phe Val Glu Pro Cys Ile Val Glu Ser Lys Asp Pro           
    425                 430                 435                           

cag gag ccc atc atg aag gag gag atc ttc ggg cct gta ctg tct gtg       1397
Gln Glu Pro Ile Met Lys Glu Glu Ile Phe Gly Pro Val Leu Ser Val           
440                 445                 450                 455           

tac gtc tac ccg gat gac aag tac aag gag acg ctg cag ctg gtt gac       1445
Tyr Val Tyr Pro Asp Asp Lys Tyr Lys Glu Thr Leu Gln Leu Val Asp           
                460                 465                 470               

agc acc acc agc tat ggc ctc acg ggg gca gtg ttc tcc cag gat aag       1493
Ser Thr Thr Ser Tyr Gly Leu Thr Gly Ala Val Phe Ser Gln Asp Lys           
            475                 480                 485                   

gac gtc gtg cag gag gcc aca aag gtg ctg agg aat gct gcc ggc aac       1541
Asp Val Val Gln Glu Ala Thr Lys Val Leu Arg Asn Ala Ala Gly Asn           
        490                 495                 500                       

ttc tac atc aac gac aag tcc act ggc tcg ata gtg ggc cag cag ccc       1589
Phe Tyr Ile Asn Asp Lys Ser Thr Gly Ser Ile Val Gly Gln Gln Pro           
    505                 510                 515                           

ttt ggg ggg gcc cga gcc tct gga acc aat gac aag cca ggg ggc cca       1637
Phe Gly Gly Ala Arg Ala Ser Gly Thr Asn Asp Lys Pro Gly Gly Pro           
520                 525                 530                 535           

cac tac atc ctg cgc tgg acg tcg ccg cag gtc atc aag gag aca cat       1685
His Tyr Ile Leu Arg Trp Thr Ser Pro Gln Val Ile Lys Glu Thr His           
                540                 545                 550               

aag ccc ctg ggg gac tgg agc tac gcg tac atg cag tga gcccctctcg        1734
Lys Pro Leu Gly Asp Trp Ser Tyr Ala Tyr Met Gln                           
            555                 560                                       

ggctccaccg tccagctgtc tgtccgtcca ggtggccgac ctcactgcac agaccccact     1794

ccagcccctc caccccttct tcatgcacag ctgcctttct ataatccggg cttgactccc     1854

ttcttaccac tgtattctgg cctctcccat gcctcaggct ctggtttgag atcgtgctgg     1914

ggaggaacat ggccactacc ccttatccca tcggccatgt gggaggtatg accctggtgc     1974

ctggcaggtt ctccctctgc cctccactgg gcccagtggc tcagggacct ggggaaagga     2034

gatggagcag ctcttgggat cctttgggga aaaggaggcc attctgggcc ccttggcaaa     2094

cctcaccact cacagaggct cctggccttg atccctgccc ctccaggtgt ccagggtaaa     2154

gtgtaactca gactgacctg tggggcacag ggggcaccag ctggccttgc cctctctggt     2214

ctgggctgtc taccttcctc actgtatctt tgcccagacc cacctgggcc agtaggcccc     2274

tgtccccagc cacacacctt agatgctggc atgccttact ccaggtgcct gtgtttggcc     2334

gaggcctgtg tgattcccgg tctgcaccac atggcggggt tggggggccg ctggaggcca     2394

cctgccaagg cgtgggatgg gatggtcctg ccggtttagg ccgtgattct ggaaaacctt     2454

ggatgggcct tcgtcctatg tcagccttcc ctttgatcct caggccctac ctgtagagac     2514

ctccactcct agagccagtc tcagggtctg ggatttccct gcaggagctc agccaccact     2574

gtgccatggt gacacaggcc aaggcagaca ttggccctcc cttctcccag cccccagagg     2634

cctggccttg ggttcgtcag catgggccga ggacgttgcc tgtagaatcc tcctctgcct     2694

gggagtggct ctgtgtggac cagtccctca ctggcccatt ctttttttga cgcagccaat     2754

ctgtgaccac gattcctccc acagatgcct cctgcttgga ttctgagtgg tcagagatct     2814

gtaaagcatg actttcaagg atggttctta ggggactgtg aaagtgttgg gtcttcctcc     2874

aggatgcctg catgggaccc cacccggagc tggtgtggcc attccccaag tgccactggc     2934

ccatggatgg gggtgggtgc tggtgccagc tgggctgggt gtgggttctg tgtccttcca     2994

ggatatgtgt catttcccat gaggggccgg ggcaggtggc tgggtggggg cacaggctgg     3054

agtattctta gttctactgg ttctacactg tgaggtggca atgggatttg ctcagatgcc     3114

acccaataaa atgcctgtta cttaa                                           3139


<210>  2
<211>  563
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Leu Pro Ala Pro Ala Leu Arg Arg Ala Leu Leu Ser Arg Pro 
1               5                   10                  15      


Trp Thr Gly Ala Gly Leu Arg Trp Lys His Thr Ser Ser Leu Lys Val 
            20                  25                  30          


Ala Asn Glu Pro Val Leu Ala Phe Thr Gln Gly Ser Pro Glu Arg Asp 
        35                  40                  45              


Ala Leu Gln Lys Ala Leu Lys Asp Leu Lys Gly Arg Met Glu Ala Ile 
    50                  55                  60                  


Pro Cys Val Val Gly Asp Glu Glu Val Trp Thr Ser Asp Val Gln Tyr 
65                  70                  75                  80  


Gln Val Ser Pro Phe Asn His Gly His Lys Val Ala Lys Phe Cys Tyr 
                85                  90                  95      


Ala Asp Lys Ser Leu Leu Asn Lys Ala Ile Glu Ala Ala Leu Ala Ala 
            100                 105                 110         


Arg Lys Glu Trp Asp Leu Lys Pro Ile Ala Asp Arg Ala Gln Ile Phe 
        115                 120                 125             


Leu Lys Ala Ala Asp Met Leu Ser Gly Pro Arg Arg Ala Glu Ile Leu 
    130                 135                 140                 


Ala Lys Thr Met Val Gly Gln Gly Lys Thr Val Ile Gln Ala Glu Ile 
145                 150                 155                 160 


Asp Ala Ala Ala Glu Leu Ile Asp Phe Phe Arg Phe Asn Ala Lys Tyr 
                165                 170                 175     


Ala Val Glu Leu Glu Gly Gln Gln Pro Ile Ser Val Pro Pro Ser Thr 
            180                 185                 190         


Asn Ser Thr Val Tyr Arg Gly Leu Glu Gly Phe Val Ala Ala Ile Ser 
        195                 200                 205             


Pro Phe Asn Phe Thr Ala Ile Gly Gly Asn Leu Ala Gly Ala Pro Ala 
    210                 215                 220                 


Leu Met Gly Asn Val Val Leu Trp Lys Pro Ser Asp Thr Ala Met Leu 
225                 230                 235                 240 


Ala Ser Tyr Ala Val Tyr Arg Ile Leu Arg Glu Ala Gly Leu Pro Pro 
                245                 250                 255     


Asn Ile Ile Gln Phe Val Pro Ala Asp Gly Pro Leu Phe Gly Asp Thr 
            260                 265                 270         


Val Thr Ser Ser Glu His Leu Cys Gly Ile Asn Phe Thr Gly Ser Val 
        275                 280                 285             


Pro Thr Phe Lys His Leu Trp Lys Gln Val Ala Gln Asn Leu Asp Arg 
    290                 295                 300                 


Phe His Thr Phe Pro Arg Leu Ala Gly Glu Cys Gly Gly Lys Asn Phe 
305                 310                 315                 320 


His Phe Val His Arg Ser Ala Asp Val Glu Ser Val Val Ser Gly Thr 
                325                 330                 335     


Leu Arg Ser Ala Phe Glu Tyr Gly Gly Gln Lys Cys Ser Ala Cys Ser 
            340                 345                 350         


Arg Leu Tyr Val Pro His Ser Leu Trp Pro Gln Ile Lys Gly Arg Leu 
        355                 360                 365             


Leu Glu Glu His Ser Arg Ile Lys Val Gly Asp Pro Ala Glu Asp Phe 
    370                 375                 380                 


Gly Thr Phe Phe Ser Ala Val Ile Asp Ala Lys Ser Phe Ala Arg Ile 
385                 390                 395                 400 


Lys Lys Trp Leu Glu His Ala Arg Ser Ser Pro Ser Leu Thr Ile Leu 
                405                 410                 415     


Ala Gly Gly Lys Cys Asp Asp Ser Val Gly Tyr Phe Val Glu Pro Cys 
            420                 425                 430         


Ile Val Glu Ser Lys Asp Pro Gln Glu Pro Ile Met Lys Glu Glu Ile 
        435                 440                 445             


Phe Gly Pro Val Leu Ser Val Tyr Val Tyr Pro Asp Asp Lys Tyr Lys 
    450                 455                 460                 


Glu Thr Leu Gln Leu Val Asp Ser Thr Thr Ser Tyr Gly Leu Thr Gly 
465                 470                 475                 480 


Ala Val Phe Ser Gln Asp Lys Asp Val Val Gln Glu Ala Thr Lys Val 
                485                 490                 495     


Leu Arg Asn Ala Ala Gly Asn Phe Tyr Ile Asn Asp Lys Ser Thr Gly 
            500                 505                 510         


Ser Ile Val Gly Gln Gln Pro Phe Gly Gly Ala Arg Ala Ser Gly Thr 
        515                 520                 525             


Asn Asp Lys Pro Gly Gly Pro His Tyr Ile Leu Arg Trp Thr Ser Pro 
    530                 535                 540                 


Gln Val Ile Lys Glu Thr His Lys Pro Leu Gly Asp Trp Ser Tyr Ala 
545                 550                 555                 560 


Tyr Met Gln 
            


<210>  3
<211>  2116
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (186)..(1214)

<400>  3
gacgtcatcc cgcagcgccg gaagcggtga ggcacagatg agtaacgtga atttgtccgt       60

ctccgacttc tggagattta ttttttttag atgaggtgtt gctgtgttgc ccaagctgga      120

cttgaacccc taggctcaag caatccttcc acctcagtct cccaagtagc agggactaca      180

gagtg atg atg cgg gtg tgc tgg ttg gtg aga cag gac agc cgg cac cag      230
      Met Met Arg Val Cys Trp Leu Val Arg Gln Asp Ser Arg His Gln         
      1               5                   10                  15          

cga atc aga ctt cca cat ttg gaa gca gtt gtg att ggg cgt ggc cca        278
Arg Ile Arg Leu Pro His Leu Glu Ala Val Val Ile Gly Arg Gly Pro           
                20                  25                  30                

gag acc aag atc act gat aag aaa tgt tct cga cag caa gta cag ttg        326
Glu Thr Lys Ile Thr Asp Lys Lys Cys Ser Arg Gln Gln Val Gln Leu           
            35                  40                  45                    

aaa gca gag tgt aac aag gga tat gtc aag gta aag cag gta gga gtc        374
Lys Ala Glu Cys Asn Lys Gly Tyr Val Lys Val Lys Gln Val Gly Val           
        50                  55                  60                        

aat ccc acc agc att gac tca gtc gta att ggg aag gac caa gag gtg        422
Asn Pro Thr Ser Ile Asp Ser Val Val Ile Gly Lys Asp Gln Glu Val           
    65                  70                  75                            

aag ctg cag cct ggc cag gtt ctc cac atg gtg aat gaa ctt tat cca        470
Lys Leu Gln Pro Gly Gln Val Leu His Met Val Asn Glu Leu Tyr Pro           
80                  85                  90                  95            

tat att gta gag ttt gag gaa gag gca aag aac cct ggc ctg gaa aca        518
Tyr Ile Val Glu Phe Glu Glu Glu Ala Lys Asn Pro Gly Leu Glu Thr           
                100                 105                 110               

cac agg aag aga aag aga tca ggc aac agt gat tct ata gaa agg gat        566
His Arg Lys Arg Lys Arg Ser Gly Asn Ser Asp Ser Ile Glu Arg Asp           
            115                 120                 125                   

gct gct cag gaa gct gag gct ggg aca ggg ctg gaa cct ggg agc aac        614
Ala Ala Gln Glu Ala Glu Ala Gly Thr Gly Leu Glu Pro Gly Ser Asn           
        130                 135                 140                       

tct ggc caa tgc tct gtg ccc cta aag aag gga aaa gat gca cct atc        662
Ser Gly Gln Cys Ser Val Pro Leu Lys Lys Gly Lys Asp Ala Pro Ile           
    145                 150                 155                           

aaa aag gaa tcc ctg ggc cac tgg agt caa ggc ttg aag att tct atg        710
Lys Lys Glu Ser Leu Gly His Trp Ser Gln Gly Leu Lys Ile Ser Met           
160                 165                 170                 175           

cag gac ccc aaa atg cag gtt tac aaa gat gag cag gtg gtg gtg ata        758
Gln Asp Pro Lys Met Gln Val Tyr Lys Asp Glu Gln Val Val Val Ile           
                180                 185                 190               

aag gat aaa tac cca aag gcc cgt tac cat tgg ctg gtc tta ccg tgg        806
Lys Asp Lys Tyr Pro Lys Ala Arg Tyr His Trp Leu Val Leu Pro Trp           
            195                 200                 205                   

acc tcc att tcc agt ctg aag gct gtg gcc agg gaa cac ctt gaa ctc        854
Thr Ser Ile Ser Ser Leu Lys Ala Val Ala Arg Glu His Leu Glu Leu           
        210                 215                 220                       

ctt aag cat atg cac act gtg ggg gaa aag gtg att gta gat ttt gct        902
Leu Lys His Met His Thr Val Gly Glu Lys Val Ile Val Asp Phe Ala           
    225                 230                 235                           

ggg tcc agc aaa ctc cgc ttc cga ttg ggc tac cac gcc att ccg agt        950
Gly Ser Ser Lys Leu Arg Phe Arg Leu Gly Tyr His Ala Ile Pro Ser           
240                 245                 250                 255           

atg agc cat gta cat ctt cat gtg atc agc cag gat ttt gat tct cct        998
Met Ser His Val His Leu His Val Ile Ser Gln Asp Phe Asp Ser Pro           
                260                 265                 270               

tgc ctt aaa aac aaa aaa cat tgg aat tct ttc aat aca gaa tac ttc       1046
Cys Leu Lys Asn Lys Lys His Trp Asn Ser Phe Asn Thr Glu Tyr Phe           
            275                 280                 285                   

cta gaa tca caa gct gtg atc gag atg gta caa gag gct ggt aga gta       1094
Leu Glu Ser Gln Ala Val Ile Glu Met Val Gln Glu Ala Gly Arg Val           
        290                 295                 300                       

act gtc cga gat ggg atg cct gag ctc ttg aag ctg ccc ctt cgt tgt       1142
Thr Val Arg Asp Gly Met Pro Glu Leu Leu Lys Leu Pro Leu Arg Cys           
    305                 310                 315                           

cat gag tgc cag cag ctg ctg cct tcc att cct cag ctg aaa gaa cat       1190
His Glu Cys Gln Gln Leu Leu Pro Ser Ile Pro Gln Leu Lys Glu His           
320                 325                 330                 335           

ctc agg aag cac tgg aca cag tga ttctgcagag cctgagctgc tgctgtggtg      1244
Leu Arg Lys His Trp Thr Gln                                               
                340                                                       

tggcccactg gagcaaactg ctggcaccta ttctgggttg cttgtgaact tctactcatt     1304

tcctaaatta aaacatgcag ctttttcaca aatttattct attattgagt ggccacaatg     1364

tagagtggct caaagtactt caggattagg aatttgggtt tgtcatagat gtattctctg     1424

gtgagggtgg ctgggatata cctgacccac catcttcaga aggacccatg tcaggtctga     1484

ccattgggag caaagccatg ttcacactga cctaatgcag agtatggaag cattgggctg     1544

gttatacatt tctgtttctt agatttatcc tccgcctctg taggcatgga caacctttaa     1604

tcagagcatc tagagtggcc tcttgtttat cctgaagata ctgatgggtc ttgttttctg     1664

ttagtctgtt ttgtaatatt cttttccctt ccttcatggg gaggcttagt ttgtccagtc     1724

cttccatgcc cttctatccc agattaccta aatgttccct tctcaggaat tctgtctcat     1784

cagttcttca cagtgagaaa agaggctaga tgatggtgtg gggggttgga gttttcttct     1844

aataccgagg gttcctggct gtgaggaaac agccacatgt tcgtcatgat tgagctgtga     1904

agtcttcttg gacctgttgt ctgaaaataa agttaatttg tttgaggcat ctctcttaag     1964

taggtggaaa ctattgaagt tcagctaaca atcacagcat aggttctgat gcatggaaag     2024

gtggttggtg aatgaaaaag ttgcgtagag ccactacttt ctttttccct gagaataaat     2084

ttggataaaa cagttgtatt caaaaaaaaa aa                                   2116


<210>  4
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Met Arg Val Cys Trp Leu Val Arg Gln Asp Ser Arg His Gln Arg 
1               5                   10                  15      


Ile Arg Leu Pro His Leu Glu Ala Val Val Ile Gly Arg Gly Pro Glu 
            20                  25                  30          


Thr Lys Ile Thr Asp Lys Lys Cys Ser Arg Gln Gln Val Gln Leu Lys 
        35                  40                  45              


Ala Glu Cys Asn Lys Gly Tyr Val Lys Val Lys Gln Val Gly Val Asn 
    50                  55                  60                  


Pro Thr Ser Ile Asp Ser Val Val Ile Gly Lys Asp Gln Glu Val Lys 
65                  70                  75                  80  


Leu Gln Pro Gly Gln Val Leu His Met Val Asn Glu Leu Tyr Pro Tyr 
                85                  90                  95      


Ile Val Glu Phe Glu Glu Glu Ala Lys Asn Pro Gly Leu Glu Thr His 
            100                 105                 110         


Arg Lys Arg Lys Arg Ser Gly Asn Ser Asp Ser Ile Glu Arg Asp Ala 
        115                 120                 125             


Ala Gln Glu Ala Glu Ala Gly Thr Gly Leu Glu Pro Gly Ser Asn Ser 
    130                 135                 140                 


Gly Gln Cys Ser Val Pro Leu Lys Lys Gly Lys Asp Ala Pro Ile Lys 
145                 150                 155                 160 


Lys Glu Ser Leu Gly His Trp Ser Gln Gly Leu Lys Ile Ser Met Gln 
                165                 170                 175     


Asp Pro Lys Met Gln Val Tyr Lys Asp Glu Gln Val Val Val Ile Lys 
            180                 185                 190         


Asp Lys Tyr Pro Lys Ala Arg Tyr His Trp Leu Val Leu Pro Trp Thr 
        195                 200                 205             


Ser Ile Ser Ser Leu Lys Ala Val Ala Arg Glu His Leu Glu Leu Leu 
    210                 215                 220                 


Lys His Met His Thr Val Gly Glu Lys Val Ile Val Asp Phe Ala Gly 
225                 230                 235                 240 


Ser Ser Lys Leu Arg Phe Arg Leu Gly Tyr His Ala Ile Pro Ser Met 
                245                 250                 255     


Ser His Val His Leu His Val Ile Ser Gln Asp Phe Asp Ser Pro Cys 
            260                 265                 270         


Leu Lys Asn Lys Lys His Trp Asn Ser Phe Asn Thr Glu Tyr Phe Leu 
        275                 280                 285             


Glu Ser Gln Ala Val Ile Glu Met Val Gln Glu Ala Gly Arg Val Thr 
    290                 295                 300                 


Val Arg Asp Gly Met Pro Glu Leu Leu Lys Leu Pro Leu Arg Cys His 
305                 310                 315                 320 


Glu Cys Gln Gln Leu Leu Pro Ser Ile Pro Gln Leu Lys Glu His Leu 
                325                 330                 335     


Arg Lys His Trp Thr Gln 
            340         


<210>  5
<211>  4371
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (2065)..(2739)

<400>  5
gctcttgccc aagccactga gagcgggacg cggggctagg tcagagtagg aaggagtcgc       60

tgagctgaat ctttgtggag tggagtgggg cgagagtcct ccgagtagtc tggaaaatta      120

gacttctgag ccttaattca tacttataag cagctagtaa attgtaaaat atagtgaagc      180

aatgtagtgt agtaactaaa accccaagct ttggagccag attgggcctt taaccctaaa      240

gttgccgttt attttgactg gcgagtcatt tacttataga tttatttatt tttattttta      300

tttttttctg agacagggtc tcactctgtc ttctaggctg ttgtgcagtg gtgcgatctt      360

ggctcactac aacctccgcc tcccgggttc aagcgattgt cccacctcag cctcctgagt      420

agctgggatt acaggcttcc accatcacgc ctggctgatg tttgtatttt cagtagagag      480

ggggtttcac catgttggcc aggctggtgt cgatctcctg acctcgagtg atccgcccgc      540

ctcggcctcc caatgtgctg ggattacagg cgtgagccac cgcgcctggc catttaatta      600

actctttaat actgtttctc ctgtaagatg aactagctgt gagaggtttc tgggatattg      660

gttcactcag caaggatgtt taaaaatgcc ttctatgtgc cagacgctgt tgtaggtacc      720

gggaatatgg cggttaaatt aagagggtga aggtttctgc tctgatacag tttatattct      780

aaatgtgaga ggacagacca gttagataga tgtaaattaa ataattaaat agatgatttt      840

tacatactgt agagctatag agaaaatata gctggatggg tgatagtgac ttggggatgg      900

gggtggctac tctggatagg gtagtttaag gtgacatctc tgtgcagatg tagaatgggc      960

tagtgctttc taagaactga aagatcagtg aagaagggga gcatagtgac tgaggagtag     1020

tgtggcatta gatggggtct gagagttaca caggaacatg tggagcctgt aggccatgca     1080

aggccatcag tgaagagaaa gagtgggaga aaaaggtttg aggagagaag gtataggact     1140

ttcactaacc ttggaccata tatttgccag gaagaatgta agttctccaa catcttcaaa     1200

taaagaagtg gttatgagga atgatcagaa taatggagat atgaaaccat tccagaattt     1260

cacaacaata ccaatcacac agagggtcca tgtgcagatt tgttacgtga gaatagtgca     1320

taatgctgga gtttgcggta tgaatcccat caccctgata gctctcaact acaatctgag     1380

caaagaaggg catttagaaa aagaaccttg gaatgcattc agccatcatg gcccagttaa     1440

tgtctccatc aatggaattc cttgcattct cttctgggcc aaaagaataa tgattaaatt     1500

taagaatcaa acctggctgg accttacaga cgagccattt ggtcagaagg taactgtgga     1560

ccctgacaac tcaaattgca gtgaagaaag tgctagaaaa aaaaagtagg ctcctttgta     1620

taggaccctg acacacatct ttgaggaagt atttactgtc taaaataaag gaacaagtca     1680

gaagttaact tcaaaaattg ttggctgggc atggtggctc acgcctgtaa tcccagcact     1740

tcgggaggcc aagggagtgg atcacctgag gtcaggagtt ggagacaagc ctggccaaca     1800

tggtgaaacc tcgtctctac taaaatacaa aaattagccg ggcgtggtgg caggtgcctg     1860

taatcccagc tactcaggag gctgagacag gagaattgct tgaacctggg aggtggaggt     1920

tgtggtgagc tgagatcgcg ccattgctct ccagcttggg tgacagagtg agtgagactc     1980

catctcaaaa aaaaaaaatt gttatatttt cccggcagtt ttcttctgaa cctttttgct     2040

aattgtcgga ataacttgta gaaa atg aga ctt tgg aaa gca agg gtt ctc        2091
                           Met Arg Leu Trp Lys Ala Arg Val Leu            
                           1               5                              

aaa ctc gtt ttg aaa aca gca aag gat tcc agg ctt ggt ctc aac tcc       2139
Lys Leu Val Leu Lys Thr Ala Lys Asp Ser Arg Leu Gly Leu Asn Ser           
10                  15                  20                  25            

aaa tgg ttg tct ttg aag ctt ggt gat gct gga aac ccc aga agt ctt       2187
Lys Trp Leu Ser Leu Lys Leu Gly Asp Ala Gly Asn Pro Arg Ser Leu           
                30                  35                  40                

gct ata aga ttc atc ctt acc aat tac aac aag ttg tcc atc cag agt       2235
Ala Ile Arg Phe Ile Leu Thr Asn Tyr Asn Lys Leu Ser Ile Gln Ser           
            45                  50                  55                    

tgg ttt agt ttg cgc cga gtc gag atc att tcc aac aat tca atc caa       2283
Trp Phe Ser Leu Arg Arg Val Glu Ile Ile Ser Asn Asn Ser Ile Gln           
        60                  65                  70                        

gca gtc ttt aac cca act ggc gta tat gct ccc tct ggt tac tcc tac       2331
Ala Val Phe Asn Pro Thr Gly Val Tyr Ala Pro Ser Gly Tyr Ser Tyr           
    75                  80                  85                            

cgc tgc caa cgc gtg ggc agc ctg cag cag gac cag gcc ctc ttg ctg       2379
Arg Cys Gln Arg Val Gly Ser Leu Gln Gln Asp Gln Ala Leu Leu Leu           
90                  95                  100                 105           

ccc agc gac acg gat gat ggg tcg agc ctg tgg gag gtc act ttt att       2427
Pro Ser Asp Thr Asp Asp Gly Ser Ser Leu Trp Glu Val Thr Phe Ile           
                110                 115                 120               

gat ttc cag atc caa ggt ttt gcc atc aag ggg gga cga ttt acc aaa       2475
Asp Phe Gln Ile Gln Gly Phe Ala Ile Lys Gly Gly Arg Phe Thr Lys           
            125                 130                 135                   

gcc caa gac tgc gcc tcc tcc ttc tcg cca gct ttt ctg atc ggc ctg       2523
Ala Gln Asp Cys Ala Ser Ser Phe Ser Pro Ala Phe Leu Ile Gly Leu           
        140                 145                 150                       

gca atg tcc ctg atc ctg ctg ctg gtg ttg gcc tat gcc ctg cac atg       2571
Ala Met Ser Leu Ile Leu Leu Leu Val Leu Ala Tyr Ala Leu His Met           
    155                 160                 165                           

ctc atc tac ctg cgg tat ctg gac caa caa tat gat ctc atc gcc tct       2619
Leu Ile Tyr Leu Arg Tyr Leu Asp Gln Gln Tyr Asp Leu Ile Ala Ser           
170                 175                 180                 185           

cct gcc cac ttc tcg cag ctg aaa gct cga gac aca gcc gaa gag aag       2667
Pro Ala His Phe Ser Gln Leu Lys Ala Arg Asp Thr Ala Glu Glu Lys           
                190                 195                 200               

gag ctg ctg agg agc cag ggg gct gaa tgc tat aaa ctg aga agc caa       2715
Glu Leu Leu Arg Ser Gln Gly Ala Glu Cys Tyr Lys Leu Arg Ser Gln           
            205                 210                 215                   

cag atc agc aaa atc tat gtt tag cagcacaggc tggcccccac catgtccaca      2769
Gln Ile Ser Lys Ile Tyr Val                                               
        220                                                               

gtgggctccg aaagttgtct ctgttctgtg ctatttgact tgtgaattac agattttcac     2829

caaatggctt gattacaaaa aaaaagaaaa aacacaaaaa ggaaatagat aatgaattct     2889

ttttgaacca tccactggcc tacttaggta gacttggggc aatcaaaaaa ggcatctcag     2949

ggatcccaca gagacaaata tgactgttag ttgcctcaaa gtaccctgaa agcaaagggg     3009

tatttcaagt acggaaaaag agagagagag aagaagaagg aggaggagga ggaggaggag     3069

aaggagaagg aggagcagga ggaagaggag gaggaggagg aaagggaggg agggagggag     3129

agggagagag agagaaagat tggcaacaca gagaagggaa aacacacttg gtcctccttg     3189

cctgtgccag tttggatgtg acaattatag aaataataaa ccaagattat ctggaagttc     3249

ataatttaaa ctattttgta acataatttg catttctaga tattatgtcc caattttgtt     3309

ttaaaaacag tctttttctc tttcatagaa atgttgaggg aggactcaac atgtggcaga     3369

gcactttatt taaggacctt cttgtccttt actgtgctgt tcagaagcag tacagctcca     3429

tctgtgaagt aggggtaata gtcatggcca tattttacct ttccatttgg gaaggggcca     3489

gggttgtctc acttgtctga tttagacctc catgagctct cataggtcca cttggaataa     3549

acagtagagc taagcaataa cagtgtgctt gctatgcaaa cacagctttg agacattccc     3609

ctgatcttcc ttccaatgag atagtgccct ctaaatgctt cctgaataga aattctggag     3669

ccaccactga tgttcttacc attgctgtct ttcatatgca ttcctcatca tccttttcag     3729

ctcttggcag atactgaaga ttgattcaac cttcatcctc accaaagcgt ctctaataat     3789

ataccttctg tcttaaagag atcttaaaca taaagatgac attgcatttt cccaggtagg     3849

gtttggtaca ggacctaggt tctactaaga agatactcct acacaaaact tagaatgcag     3909

acaggaaaca tgtgcagtgg agggtcacac acagagcaag aaaatcttct gggcagctgt     3969

cacgatgagt ctgctgtcta gtcccatcct aggtggtaag cagtagatga taatgacagt     4029

tttctgatgg gacagtctca tgttgagcat ttattttggc tgcaattttc ttggttatga     4089

atgtaggttt ggttctggcc ctctcagaat tctgtaagat cccatacttt atagtaaatt     4149

tctttctgtt ttaataacag agttgattct gtagtctgca gtgaagaatc ctgatttatg     4209

tagttgttag taccaagagg attgcaggga acagactctc aagaaaatgc aaatctatga     4269

ttgattatcc aactccattt ggctttaaac cagtggaaac tgtcagcctt agagaatggt     4329

attcaataat aaaacagatt tttattgtgg ttcccttgag ca                        4371


<210>  6
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Leu Trp Lys Ala Arg Val Leu Lys Leu Val Leu Lys Thr Ala 
1               5                   10                  15      


Lys Asp Ser Arg Leu Gly Leu Asn Ser Lys Trp Leu Ser Leu Lys Leu 
            20                  25                  30          


Gly Asp Ala Gly Asn Pro Arg Ser Leu Ala Ile Arg Phe Ile Leu Thr 
        35                  40                  45              


Asn Tyr Asn Lys Leu Ser Ile Gln Ser Trp Phe Ser Leu Arg Arg Val 
    50                  55                  60                  


Glu Ile Ile Ser Asn Asn Ser Ile Gln Ala Val Phe Asn Pro Thr Gly 
65                  70                  75                  80  


Val Tyr Ala Pro Ser Gly Tyr Ser Tyr Arg Cys Gln Arg Val Gly Ser 
                85                  90                  95      


Leu Gln Gln Asp Gln Ala Leu Leu Leu Pro Ser Asp Thr Asp Asp Gly 
            100                 105                 110         


Ser Ser Leu Trp Glu Val Thr Phe Ile Asp Phe Gln Ile Gln Gly Phe 
        115                 120                 125             


Ala Ile Lys Gly Gly Arg Phe Thr Lys Ala Gln Asp Cys Ala Ser Ser 
    130                 135                 140                 


Phe Ser Pro Ala Phe Leu Ile Gly Leu Ala Met Ser Leu Ile Leu Leu 
145                 150                 155                 160 


Leu Val Leu Ala Tyr Ala Leu His Met Leu Ile Tyr Leu Arg Tyr Leu 
                165                 170                 175     


Asp Gln Gln Tyr Asp Leu Ile Ala Ser Pro Ala His Phe Ser Gln Leu 
            180                 185                 190         


Lys Ala Arg Asp Thr Ala Glu Glu Lys Glu Leu Leu Arg Ser Gln Gly 
        195                 200                 205             


Ala Glu Cys Tyr Lys Leu Arg Ser Gln Gln Ile Ser Lys Ile Tyr Val 
    210                 215                 220                 


<210>  7
<211>  2029
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (114)..(1415)

<400>  7
ggcgtgctgc ggcggaacgg ctgttggttt ctgctgggtg taggtccttg gctggtcggg       60

cctccggtgt tctgcttctc cccgctgagc tgctgcctgg tgaagaggaa gcc atg         116
                                                           Met            
                                                           1              

gcg ctc cga gtc acc agg aac tcg aaa att aat gct gaa aat aag gcg        164
Ala Leu Arg Val Thr Arg Asn Ser Lys Ile Asn Ala Glu Asn Lys Ala           
            5                   10                  15                    

aag atc aac atg gca ggc gca aag cgc gtt cct acg gcc cct gct gca        212
Lys Ile Asn Met Ala Gly Ala Lys Arg Val Pro Thr Ala Pro Ala Ala           
        20                  25                  30                        

acc tcc aag ccc gga ctg agg cca aga aca gct ctt ggg gac att ggt        260
Thr Ser Lys Pro Gly Leu Arg Pro Arg Thr Ala Leu Gly Asp Ile Gly           
    35                  40                  45                            

aac aaa gtc agt gaa caa ctg cag gcc aaa atg cct atg aag aag gaa        308
Asn Lys Val Ser Glu Gln Leu Gln Ala Lys Met Pro Met Lys Lys Glu           
50                  55                  60                  65            

gca aaa cct tca gct act gga aaa gtc att gat aaa aaa cta cca aaa        356
Ala Lys Pro Ser Ala Thr Gly Lys Val Ile Asp Lys Lys Leu Pro Lys           
                70                  75                  80                

cct ctt gaa aag gta cct atg ctg gtg cca gtg cca gtg tct gag cca        404
Pro Leu Glu Lys Val Pro Met Leu Val Pro Val Pro Val Ser Glu Pro           
            85                  90                  95                    

gtg cca gag cca gaa cct gag cca gaa cct gag cct gtt aaa gaa gaa        452
Val Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Lys Glu Glu           
        100                 105                 110                       

aaa ctt tcg cct gag cct att ttg gtt gat act gcc tct cca agc cca        500
Lys Leu Ser Pro Glu Pro Ile Leu Val Asp Thr Ala Ser Pro Ser Pro           
    115                 120                 125                           

atg gaa aca tct gga tgt gcc cct gca gaa gaa gac ctg tgt cag gct        548
Met Glu Thr Ser Gly Cys Ala Pro Ala Glu Glu Asp Leu Cys Gln Ala           
130                 135                 140                 145           

ttc tct gat gta att ctt gca gta aat gat gtg gat gca gaa gat gga        596
Phe Ser Asp Val Ile Leu Ala Val Asn Asp Val Asp Ala Glu Asp Gly           
                150                 155                 160               

gct gat cca aac ctt tgt agt gaa tat gtg aaa gat att tat gct tat        644
Ala Asp Pro Asn Leu Cys Ser Glu Tyr Val Lys Asp Ile Tyr Ala Tyr           
            165                 170                 175                   

ctg aga caa ctt gag gaa gag caa gca gtc aga cca aaa tac cta ctg        692
Leu Arg Gln Leu Glu Glu Glu Gln Ala Val Arg Pro Lys Tyr Leu Leu           
        180                 185                 190                       

ggt cgg gaa gtc act gga aac atg aga gcc atc cta att gac tgg cta        740
Gly Arg Glu Val Thr Gly Asn Met Arg Ala Ile Leu Ile Asp Trp Leu           
    195                 200                 205                           

gta cag gtt caa atg aaa ttc agg ttg ttg cag gag acc atg tac atg        788
Val Gln Val Gln Met Lys Phe Arg Leu Leu Gln Glu Thr Met Tyr Met           
210                 215                 220                 225           

act gtc tcc att att gat cgg ttc atg cag aat aat tgt gtg ccc aag        836
Thr Val Ser Ile Ile Asp Arg Phe Met Gln Asn Asn Cys Val Pro Lys           
                230                 235                 240               

aag atg ctg cag ctg gtt ggt gtc act gcc atg ttt att gca agc aaa        884
Lys Met Leu Gln Leu Val Gly Val Thr Ala Met Phe Ile Ala Ser Lys           
            245                 250                 255                   

tat gaa gaa atg tac cct cca gaa att ggt gac ttt gct ttt gtg act        932
Tyr Glu Glu Met Tyr Pro Pro Glu Ile Gly Asp Phe Ala Phe Val Thr           
        260                 265                 270                       

gac aac act tat act aag cac caa atc aga cag atg gaa atg aag att        980
Asp Asn Thr Tyr Thr Lys His Gln Ile Arg Gln Met Glu Met Lys Ile           
    275                 280                 285                           

cta aga gct tta aac ttt ggt ctg ggt cgg cct cta cct ttg cac ttc       1028
Leu Arg Ala Leu Asn Phe Gly Leu Gly Arg Pro Leu Pro Leu His Phe           
290                 295                 300                 305           

ctt cgg aga gca tct aag att gga gag gtt gat gtc gag caa cat act       1076
Leu Arg Arg Ala Ser Lys Ile Gly Glu Val Asp Val Glu Gln His Thr           
                310                 315                 320               

ttg gcc aaa tac ctg atg gaa cta act atg ttg gac tat gac atg gtg       1124
Leu Ala Lys Tyr Leu Met Glu Leu Thr Met Leu Asp Tyr Asp Met Val           
            325                 330                 335                   

cac ttt cct cct tct caa att gca gca gga gct ttt tgc tta gca ctg       1172
His Phe Pro Pro Ser Gln Ile Ala Ala Gly Ala Phe Cys Leu Ala Leu           
        340                 345                 350                       

aaa att ctg gat aat ggt gaa tgg aca cca act cta caa cat tac ctg       1220
Lys Ile Leu Asp Asn Gly Glu Trp Thr Pro Thr Leu Gln His Tyr Leu           
    355                 360                 365                           

tca tat act gaa gaa tct ctt ctt cca gtt atg cag cac ctg gct aag       1268
Ser Tyr Thr Glu Glu Ser Leu Leu Pro Val Met Gln His Leu Ala Lys           
370                 375                 380                 385           

aat gta gtc atg gta aat caa gga ctt aca aag cac atg act gtc aag       1316
Asn Val Val Met Val Asn Gln Gly Leu Thr Lys His Met Thr Val Lys           
                390                 395                 400               

aac aag tat gcc aca tcg aag cat gct aag atc agc act cta cca cag       1364
Asn Lys Tyr Ala Thr Ser Lys His Ala Lys Ile Ser Thr Leu Pro Gln           
            405                 410                 415                   

ctg aat tct gca cta gtt caa gat tta gcc aag gct gtg gca aag gtg       1412
Leu Asn Ser Ala Leu Val Gln Asp Leu Ala Lys Ala Val Ala Lys Val           
        420                 425                 430                       

taa cttgtaaact tgagttggag tactatattt acaaataaaa ttggcaccat            1465

gtgccatctg tacatattac tgttgcattt acttttaata aagcttgtgg ccccttttac     1525

ttttttatag cttaactaat ttgaatgtgg ttacttccta ctgtagggta gcggaaaagt     1585

tgtcttaaaa ggtatggtgg ggatattttt aaaaactcct tttggtttac ctggggatcc     1645

aattgatgta tatgtttata tactgggttc ttgttttata tacctggctt ttactttatt     1705

aatatgagtt actgaaggtg atggaggtat ttgaaaattt tacttccata ggacatactg     1765

catgtaagcc aagtcatgga gaatctgctg catagctcta ttttaaagta aaagtctacc     1825

accgaatccc tagtccccct gttttctgtt tcttcttgtg attgctgcca taattctaag     1885

ttatttactt ttaccactat ttaagttatc aactttagct agtatcttca aactttcact     1945

ttgaaaaatg agaattttat attctaagcc agttttcatt ttggttttgt gttttggtta     2005

ataaaacaat actcaaatac aaaa                                            2029


<210>  8
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Leu Arg Val Thr Arg Asn Ser Lys Ile Asn Ala Glu Asn Lys 
1               5                   10                  15      


Ala Lys Ile Asn Met Ala Gly Ala Lys Arg Val Pro Thr Ala Pro Ala 
            20                  25                  30          


Ala Thr Ser Lys Pro Gly Leu Arg Pro Arg Thr Ala Leu Gly Asp Ile 
        35                  40                  45              


Gly Asn Lys Val Ser Glu Gln Leu Gln Ala Lys Met Pro Met Lys Lys 
    50                  55                  60                  


Glu Ala Lys Pro Ser Ala Thr Gly Lys Val Ile Asp Lys Lys Leu Pro 
65                  70                  75                  80  


Lys Pro Leu Glu Lys Val Pro Met Leu Val Pro Val Pro Val Ser Glu 
                85                  90                  95      


Pro Val Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Val Lys Glu 
            100                 105                 110         


Glu Lys Leu Ser Pro Glu Pro Ile Leu Val Asp Thr Ala Ser Pro Ser 
        115                 120                 125             


Pro Met Glu Thr Ser Gly Cys Ala Pro Ala Glu Glu Asp Leu Cys Gln 
    130                 135                 140                 


Ala Phe Ser Asp Val Ile Leu Ala Val Asn Asp Val Asp Ala Glu Asp 
145                 150                 155                 160 


Gly Ala Asp Pro Asn Leu Cys Ser Glu Tyr Val Lys Asp Ile Tyr Ala 
                165                 170                 175     


Tyr Leu Arg Gln Leu Glu Glu Glu Gln Ala Val Arg Pro Lys Tyr Leu 
            180                 185                 190         


Leu Gly Arg Glu Val Thr Gly Asn Met Arg Ala Ile Leu Ile Asp Trp 
        195                 200                 205             


Leu Val Gln Val Gln Met Lys Phe Arg Leu Leu Gln Glu Thr Met Tyr 
    210                 215                 220                 


Met Thr Val Ser Ile Ile Asp Arg Phe Met Gln Asn Asn Cys Val Pro 
225                 230                 235                 240 


Lys Lys Met Leu Gln Leu Val Gly Val Thr Ala Met Phe Ile Ala Ser 
                245                 250                 255     


Lys Tyr Glu Glu Met Tyr Pro Pro Glu Ile Gly Asp Phe Ala Phe Val 
            260                 265                 270         


Thr Asp Asn Thr Tyr Thr Lys His Gln Ile Arg Gln Met Glu Met Lys 
        275                 280                 285             


Ile Leu Arg Ala Leu Asn Phe Gly Leu Gly Arg Pro Leu Pro Leu His 
    290                 295                 300                 


Phe Leu Arg Arg Ala Ser Lys Ile Gly Glu Val Asp Val Glu Gln His 
305                 310                 315                 320 


Thr Leu Ala Lys Tyr Leu Met Glu Leu Thr Met Leu Asp Tyr Asp Met 
                325                 330                 335     


Val His Phe Pro Pro Ser Gln Ile Ala Ala Gly Ala Phe Cys Leu Ala 
            340                 345                 350         


Leu Lys Ile Leu Asp Asn Gly Glu Trp Thr Pro Thr Leu Gln His Tyr 
        355                 360                 365             


Leu Ser Tyr Thr Glu Glu Ser Leu Leu Pro Val Met Gln His Leu Ala 
    370                 375                 380                 


Lys Asn Val Val Met Val Asn Gln Gly Leu Thr Lys His Met Thr Val 
385                 390                 395                 400 


Lys Asn Lys Tyr Ala Thr Ser Lys His Ala Lys Ile Ser Thr Leu Pro 
                405                 410                 415     


Gln Leu Asn Ser Ala Leu Val Gln Asp Leu Ala Lys Ala Val Ala Lys 
            420                 425                 430         


Val 
    


<210>  9
<211>  5265
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (163)..(1245)

<400>  9
ggcactcaac aggtgctctg agtggcaccc acggccaggt cctgggagag gacagaaaac       60

aactgggact cctcagcccc cggcagctcc cagtgcccag ccacccacaa cacaacccaa      120

agccttctag acaagctcag tggaatctga agggcccacc cc atg gag gaa tgc         174
                                               Met Glu Glu Cys            
                                               1                          

tgg gtg aca gag ata gcc aat ggc tcc aag gat ggc ttg gat tcc aac        222
Trp Val Thr Glu Ile Ala Asn Gly Ser Lys Asp Gly Leu Asp Ser Asn           
5                   10                  15                  20            

cct atg aag gat tac atg atc ctg agt ggt ccc cag aag aca gct gtt        270
Pro Met Lys Asp Tyr Met Ile Leu Ser Gly Pro Gln Lys Thr Ala Val           
                25                  30                  35                

gct gtg ttg tgc act ctt ctg ggc ctg cta agt gcc ctg gag aac gtg        318
Ala Val Leu Cys Thr Leu Leu Gly Leu Leu Ser Ala Leu Glu Asn Val           
            40                  45                  50                    

gct gtg ctc tat ctg atc ctg tcc tcc cac caa ctc cgc cgg aag ccc        366
Ala Val Leu Tyr Leu Ile Leu Ser Ser His Gln Leu Arg Arg Lys Pro           
        55                  60                  65                        

tca tac ctg ttc att ggc agc ttg gct ggg gct gac ttc ctg gcc agt        414
Ser Tyr Leu Phe Ile Gly Ser Leu Ala Gly Ala Asp Phe Leu Ala Ser           
    70                  75                  80                            

gtg gtc ttt gca tgc agc ttt gtg aat ttc cat gtt ttc cat ggt gtg        462
Val Val Phe Ala Cys Ser Phe Val Asn Phe His Val Phe His Gly Val           
85                  90                  95                  100           

gat tcc aag gct gtc ttc ctg ctg aag att ggc agc gtg act atg acc        510
Asp Ser Lys Ala Val Phe Leu Leu Lys Ile Gly Ser Val Thr Met Thr           
                105                 110                 115               

ttc aca gcc tct gtg ggt agc ctc ctg ctg acc gcc att gac cga tac        558
Phe Thr Ala Ser Val Gly Ser Leu Leu Leu Thr Ala Ile Asp Arg Tyr           
            120                 125                 130                   

ctc tgc ctg cgc tat cca cct tcc tac aaa gct ctg ctc acc cgt gga        606
Leu Cys Leu Arg Tyr Pro Pro Ser Tyr Lys Ala Leu Leu Thr Arg Gly           
        135                 140                 145                       

agg gca ctg gtg acc ctg ggc atc atg tgg gtc ctc tca gca cta gtc        654
Arg Ala Leu Val Thr Leu Gly Ile Met Trp Val Leu Ser Ala Leu Val           
    150                 155                 160                           

tcc tac ctg ccc ctc atg gga tgg act tgc tgt ccc agg ccc tgc tct        702
Ser Tyr Leu Pro Leu Met Gly Trp Thr Cys Cys Pro Arg Pro Cys Ser           
165                 170                 175                 180           

gag ctt ttc cca ctg atc ccc aat gac tac ctg ctg agc tgg ctc ctg        750
Glu Leu Phe Pro Leu Ile Pro Asn Asp Tyr Leu Leu Ser Trp Leu Leu           
                185                 190                 195               

ttc atc gcc ttc ctc ttt tcc gga atc atc tac acc tat ggg cat gtt        798
Phe Ile Ala Phe Leu Phe Ser Gly Ile Ile Tyr Thr Tyr Gly His Val           
            200                 205                 210                   

ctc tgg aag gcc cat cag cat gtg gcc agc ttg tct ggc cac cag gac        846
Leu Trp Lys Ala His Gln His Val Ala Ser Leu Ser Gly His Gln Asp           
        215                 220                 225                       

agg cag gtg cca gga atg gcc cga atg agg ctg gat gtg agg ttg gcc        894
Arg Gln Val Pro Gly Met Ala Arg Met Arg Leu Asp Val Arg Leu Ala           
    230                 235                 240                           

aag acc cta ggg cta gtg ttg gct gtg ctc ctc atc tgt tgg ttc cca        942
Lys Thr Leu Gly Leu Val Leu Ala Val Leu Leu Ile Cys Trp Phe Pro           
245                 250                 255                 260           

gtg ctg gcc ctc atg gcc cac agc ctg gcc act acg ctc agt gac cag        990
Val Leu Ala Leu Met Ala His Ser Leu Ala Thr Thr Leu Ser Asp Gln           
                265                 270                 275               

gtc aag aag gcc ttt gct ttc tgc tcc atg ctg tgc ctc atc aac tcc       1038
Val Lys Lys Ala Phe Ala Phe Cys Ser Met Leu Cys Leu Ile Asn Ser           
            280                 285                 290                   

atg gtc aac cct gtc atc tat gct cta cgg agt gga gag atc cgc tcc       1086
Met Val Asn Pro Val Ile Tyr Ala Leu Arg Ser Gly Glu Ile Arg Ser           
        295                 300                 305                       

tct gcc cat cac tgc ctg gct cac tgg aag aag tgt gtg agg ggc ctt       1134
Ser Ala His His Cys Leu Ala His Trp Lys Lys Cys Val Arg Gly Leu           
    310                 315                 320                           

ggg tca gag gca aaa gaa gaa gcc ccg aga tcc tca gtc acc gag aca       1182
Gly Ser Glu Ala Lys Glu Glu Ala Pro Arg Ser Ser Val Thr Glu Thr           
325                 330                 335                 340           

gag gct gat ggg aaa atc act ccg tgg cca gat tcc aga gat cta gac       1230
Glu Ala Asp Gly Lys Ile Thr Pro Trp Pro Asp Ser Arg Asp Leu Asp           
                345                 350                 355               

ctc tct gat tgc tga tgaggcctct tcccaattta aacaactcaa gtcagaaatc       1285
Leu Ser Asp Cys                                                           
            360                                                           

agttcactcc ctggaagaga gagaggggtc ttggcactct cttcttactt aaaccagtcc     1345

cagacaccta gacacggacc cctttttgct gatgagtgtt gggactgact cctggaagac     1405

agcctggcct tgcccacctg cacacagtct gttggatagg tagggccacg aggagtagcc     1465

aggtaggcga gacacaaaag gcctgggaca gggtcagtac aagtcaggtc aggcttcatg     1525

cctgcatcct ccagagacca caggagccaa agcgagcctc caggcccagc aatgagggac     1585

ttgggagaaa tctgagaaga atgggttgtt ctcttgggaa gtcagggtat cagatgggat     1645

ggacatccag gtcttctctc tgcctaattg tcaaggcctc cttggctctg gagctatgaa     1705

aggccccact ttcaagtcac ccttgccact gaggaccgag gactatgcta tgatgaggat     1765

taaggtgttg acttgcctct ttcagagata aatgacaagc cttcagtttg gggcatcctg     1825

ttgtttgggc gaggaccctc tctgatattc tgataatccc cacctgtaac ctcaggtccc     1885

tggaaataca gaggaggctg ggatcgcctg agacacaaaa atctttggag aattttcttg     1945

accctctgaa gtccttccag cagcagtcct ggtggtgctg ctggaagcag gcaatgtcct     2005

agtctaacct aactcgaaga aaaaaaggaa gatattcaca aagattgtat aaatctccaa     2065

actgttcccc tatctgcccc caattcagct cccttgcctc ctccacaccc ctattacata     2125

taataagcag agcaagtggg aggaggggaa atgtccttcc tatatgccag gtatggggct     2185

gacatttcag tctattgacc ccagctagaa tatagctcca tgattttaaa gatctcaggg     2245

gccaggcatg gtagctcatg cctgtaatcc cagcactttg ggaggccaag gcaggtggat     2305

cacctgaggt caggagtttg agaccagcct gaccaatatg gtgaaaccct gtctctacta     2365

aaaatacaaa aattagcagg gcatggtggc aggcacctgt agtcccagct actcgggagg     2425

ctgagacagg agaattgctt gaaccctgga ggcagaggtt gcagtgagcc gagattgcac     2485

cactgcactc cagcctgggt gacagagcaa gactgtctca aaaaaataaa ataaaataga     2545

tcccagggta ctcatttttc atatgaggga ggctgggttc ctcccagagg agcctaaaac     2605

agccaacaag agaaattgtt ggcggcagga agattgcaga ggaattctaa tgcaattatt     2665

tgggacctca aatggaataa aatgaaagat attggttaaa catgtcttcg tttaatactt     2725

tcaagacaaa atatccacta gctattcact tattcattca tctcataaac atgagccagg     2785

ctctgtgcag ggtcctgagt acccagccat aaatgagact gtgcccctgt ctcatggggc     2845

ttacagtcta tatcctgctt gcaagacagc caataagtca ataaagaaga taattacagg     2905

cagtacaaca aaggaaatat gcaggttcat gtcatgtaat agggattaat tgagttaact     2965

caataaacgg taggatagac ctaccatgtg ccggctcact tttattgagc ctttactatg     3025

tgccaggcag ggggctaagt gtttttaaat gccttatttc acttcatgtt tcccaacaac     3085

ctaataagaa ggtcttagtt atcttcattt tacagatgtg gcaacctcaa agatgcaaag     3145

tcacttgtct aaggtcaccc tgctaagtac cagagctgag gtctccaacc tagttctgtt     3205

tgacttcaaa gcctgccctc ttaaccacta accttttgtc ctagttcagt caaattctgc     3265

ttgattattg ctcattaggg ataatattag ctatctgtag catcagattg ctgcaaagtt     3325

aactcatcgt agattctcaa tatactccat tttattaaat ggccccgtat taatctcctg     3385

taataaattt cacaaatcca gtggcttatc aacagaaatt tactgtctca taattctgga     3445

ggccagaagt caaaatcaag atgtggtagg gccctgctcc ctccaaaagt ttaaggggag     3505

aattattcct tgactctttc aacttctggc agtccctgtc attccttggc ttgtggaaac     3565

atcactccta cctctgactc tgtcttcata tggcatttcc tctgtgtctc ttggtgtctt     3625

tttttttttt tttttttttt ttgagacgga atctcattct gttgtccagg caggagtgca     3685

gtgacatgat cttggctcac tgcaacctcc acctctcagg ttcaagtgat tctcctgcct     3745

cagcctccca aatagctggg actacaggca cccgccacca cactcagcta atttttgtat     3805

ttttagtaga gatggggttt caccatcttg cccaggctgg tcttgaactc ctgacctcaa     3865

gtgatccgcc caccttggcc tcctaaattg ctgggattac agacgtgagc caccataccc     3925

ggcctggtgt cttttttaaa gaatatcagt cactggattt gggcccaccc taatcctaat     3985

agtatgactt catcttaatt taaccaatta tatctgtaga gaccctgttt ccaaataagg     4045

tcacattcac agattccagg tggacaagaa gtttaggcgg acactattca actcagtaca     4105

gacccaggaa caaagtccac ccactgggct gtgttgagtg gcagtcacta gtttatcctc     4165

cctcaacaag atgagctcca ggttgacctc tgcatcccca gtgctcagtc aggacccagc     4225

agagcatctg aagggatctg gtcaatatgt gtggaactga actgtttctg aaaagctctg     4285

acgtatgttt tggaaaatca aatcttgttt taatccagac accaatcttt ttgtaaggca     4345

aacaagtagc ataaatgttt aaaagtgaat ttgcatgttt atatactgtc attccttaaa     4405

gttgaagcat gcctttcttt attcatcggt ggaatccttt ctcattttgg caaagaaaat     4465

gcccaagtgc ctggcacaaa caagcactga gtaaatactt cttgaatgaa taaaactaga     4525

ttctaaaaat catttgatca aacgcaactc cacactttct acttctcttc ttttagaacc     4585

acactgtatt tctgcttttt tttttttttt tttttttttt gacatagaat ctcactctgt     4645

cacccaggtt ggagtgcagt ggcatgcaat cttggctcac tgcaacctct gcctcctggg     4705

ttcaagcagt tctcctgcct tagcctccca tgtagctggg attacaggta cccgccacca     4765

tgcccagcta atttttgtat tgttagtaga gatggaattt caccatattg gccaggctgg     4825

tcttgaactc ctgacttcaa gtgatccacc caccttagcc tcccaaagtg ctaggattac     4885

aggtgtgagc caccactccc agcccctatg tctgctttaa gtggagaagc agagcttatg     4945

agggaggaga acaagggtgc aaaagggacc tagatatcac tgagaactgc ccttgttgtt     5005

tggttgagga aatgggccca gacagtggac aagacttgct cagggagaca aacgagatgg     5065

tgtccagtgc aacaaaccta ggtttcctaa cttccagttc tgtccactct acatcagtgc     5125

ctctcacctg tccctgcagg ttcacatttt ggttatgtgg ataaggagaa ataaattgaa     5185

gatcacaatg tcccatttta tcttccccaa gacaagctct gtaacattaa agaccactat     5245

gcaaaccgat tactagaaaa                                                 5265


<210>  10
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Glu Cys Trp Val Thr Glu Ile Ala Asn Gly Ser Lys Asp Gly 
1               5                   10                  15      


Leu Asp Ser Asn Pro Met Lys Asp Tyr Met Ile Leu Ser Gly Pro Gln 
            20                  25                  30          


Lys Thr Ala Val Ala Val Leu Cys Thr Leu Leu Gly Leu Leu Ser Ala 
        35                  40                  45              


Leu Glu Asn Val Ala Val Leu Tyr Leu Ile Leu Ser Ser His Gln Leu 
    50                  55                  60                  


Arg Arg Lys Pro Ser Tyr Leu Phe Ile Gly Ser Leu Ala Gly Ala Asp 
65                  70                  75                  80  


Phe Leu Ala Ser Val Val Phe Ala Cys Ser Phe Val Asn Phe His Val 
                85                  90                  95      


Phe His Gly Val Asp Ser Lys Ala Val Phe Leu Leu Lys Ile Gly Ser 
            100                 105                 110         


Val Thr Met Thr Phe Thr Ala Ser Val Gly Ser Leu Leu Leu Thr Ala 
        115                 120                 125             


Ile Asp Arg Tyr Leu Cys Leu Arg Tyr Pro Pro Ser Tyr Lys Ala Leu 
    130                 135                 140                 


Leu Thr Arg Gly Arg Ala Leu Val Thr Leu Gly Ile Met Trp Val Leu 
145                 150                 155                 160 


Ser Ala Leu Val Ser Tyr Leu Pro Leu Met Gly Trp Thr Cys Cys Pro 
                165                 170                 175     


Arg Pro Cys Ser Glu Leu Phe Pro Leu Ile Pro Asn Asp Tyr Leu Leu 
            180                 185                 190         


Ser Trp Leu Leu Phe Ile Ala Phe Leu Phe Ser Gly Ile Ile Tyr Thr 
        195                 200                 205             


Tyr Gly His Val Leu Trp Lys Ala His Gln His Val Ala Ser Leu Ser 
    210                 215                 220                 


Gly His Gln Asp Arg Gln Val Pro Gly Met Ala Arg Met Arg Leu Asp 
225                 230                 235                 240 


Val Arg Leu Ala Lys Thr Leu Gly Leu Val Leu Ala Val Leu Leu Ile 
                245                 250                 255     


Cys Trp Phe Pro Val Leu Ala Leu Met Ala His Ser Leu Ala Thr Thr 
            260                 265                 270         


Leu Ser Asp Gln Val Lys Lys Ala Phe Ala Phe Cys Ser Met Leu Cys 
        275                 280                 285             


Leu Ile Asn Ser Met Val Asn Pro Val Ile Tyr Ala Leu Arg Ser Gly 
    290                 295                 300                 


Glu Ile Arg Ser Ser Ala His His Cys Leu Ala His Trp Lys Lys Cys 
305                 310                 315                 320 


Val Arg Gly Leu Gly Ser Glu Ala Lys Glu Glu Ala Pro Arg Ser Ser 
                325                 330                 335     


Val Thr Glu Thr Glu Ala Asp Gly Lys Ile Thr Pro Trp Pro Asp Ser 
            340                 345                 350         


Arg Asp Leu Asp Leu Ser Asp Cys 
        355                 360 


<210>  11
<211>  3721
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (28)..(942)

<400>  11
gtagtacgaa tccgtcaggc cggaacc atg gca gtg acc aag gag ctc tta cag       54
                              Met Ala Val Thr Lys Glu Leu Leu Gln         
                              1               5                           

atg gac ctg tac gcg ctg cta ggc att gag gag aag gca gcg gac aaa        102
Met Asp Leu Tyr Ala Leu Leu Gly Ile Glu Glu Lys Ala Ala Asp Lys           
10                  15                  20                  25            

gag gta aag aag gcg tat agg cag aag gcc ctc tcc tgc cac cca gac        150
Glu Val Lys Lys Ala Tyr Arg Gln Lys Ala Leu Ser Cys His Pro Asp           
                30                  35                  40                

aaa aat cca gat aat ccc aga gca gct gaa ctc ttc cac cag ctt tct        198
Lys Asn Pro Asp Asn Pro Arg Ala Ala Glu Leu Phe His Gln Leu Ser           
            45                  50                  55                    

cag gcc ttg gag gtg ctg acc gat gct gca gcc agg gct gca tat gac        246
Gln Ala Leu Glu Val Leu Thr Asp Ala Ala Ala Arg Ala Ala Tyr Asp           
        60                  65                  70                        

aag gtc agg aaa gcc aag aag caa gca gca gag agg acc cag aaa ctt        294
Lys Val Arg Lys Ala Lys Lys Gln Ala Ala Glu Arg Thr Gln Lys Leu           
    75                  80                  85                            

gat gag aaa agg aag aaa gtg aag ctt gac ctg gag gcc cgg gag cgg        342
Asp Glu Lys Arg Lys Lys Val Lys Leu Asp Leu Glu Ala Arg Glu Arg           
90                  95                  100                 105           

cag gcc cag gcc cag gag agt gag gag gaa gag gag agc cgg agc acc        390
Gln Ala Gln Ala Gln Glu Ser Glu Glu Glu Glu Glu Ser Arg Ser Thr           
                110                 115                 120               

agg aca cta gag caa gag atc gaa cgc ctg aga gaa gag ggt tcc cgg        438
Arg Thr Leu Glu Gln Glu Ile Glu Arg Leu Arg Glu Glu Gly Ser Arg           
            125                 130                 135                   

cag ctg gag gaa cag cag agg ctc atc cgg gag cag ata cgc cag gag        486
Gln Leu Glu Glu Gln Gln Arg Leu Ile Arg Glu Gln Ile Arg Gln Glu           
        140                 145                 150                       

cgt gac cag agg ttg aga gga aag gca gaa aat act gaa ggc caa gga        534
Arg Asp Gln Arg Leu Arg Gly Lys Ala Glu Asn Thr Glu Gly Gln Gly           
    155                 160                 165                           

acc ccc aaa cta aag cta aaa tgg aag tgc aag aag gag gat gag tca        582
Thr Pro Lys Leu Lys Leu Lys Trp Lys Cys Lys Lys Glu Asp Glu Ser           
170                 175                 180                 185           

aaa ggt ggc tac tcc aaa gac gtc ctc cta cgg ctt ttg cag aag tat        630
Lys Gly Gly Tyr Ser Lys Asp Val Leu Leu Arg Leu Leu Gln Lys Tyr           
                190                 195                 200               

ggt gag gtt ctc aac ctg gtg ctt tcc agt aag aag cca ggc act gct        678
Gly Glu Val Leu Asn Leu Val Leu Ser Ser Lys Lys Pro Gly Thr Ala           
            205                 210                 215                   

gtg gtg gag ttt gca acc gtc aag gca gcg gag ctg gct gtc cag aat        726
Val Val Glu Phe Ala Thr Val Lys Ala Ala Glu Leu Ala Val Gln Asn           
        220                 225                 230                       

gaa gtt ggc ctg gtg gat aac cct ctg aag att tcc tgg ttg gag gga        774
Glu Val Gly Leu Val Asp Asn Pro Leu Lys Ile Ser Trp Leu Glu Gly           
    235                 240                 245                           

cag ccc cag gat gcc gtg ggc cgc agc cac tca gga ctg tca aag ggc        822
Gln Pro Gln Asp Ala Val Gly Arg Ser His Ser Gly Leu Ser Lys Gly           
250                 255                 260                 265           

tca gtg ctg tca gag agg gac tac gag agc ctc gtc atg atg cgc atg        870
Ser Val Leu Ser Glu Arg Asp Tyr Glu Ser Leu Val Met Met Arg Met           
                270                 275                 280               

cgc cag gcg gcc gag cgg caa cag ctg atc gca cgg atg cag cag gaa        918
Arg Gln Ala Ala Glu Arg Gln Gln Leu Ile Ala Arg Met Gln Gln Glu           
            285                 290                 295                   

gac cag gag ggg ccg cct acg tag ccccagctcc agccatccac ccctcagccc       972
Asp Gln Glu Gly Pro Pro Thr                                               
        300                                                               

ttttcttcaa cgtcaccaat aaattttttt tttttttaag attttacctc tatcccatac     1032

ataggtataa ggtgctgggc tctgccgcag agcgctccac ccaggcctgg cgcccctccc     1092

aggaagtggg cagaccccca gggaaacgct ccgcagggtg agagtcccag agtccgtgca     1152

caagcagagc acaggcgcag ccactcatca cagcccttta ttggcttggg ctagctatgc     1212

aggagccacg cgccagggcc gctggagtgc ccagctccgg cccggggcag ctgcccgagg     1272

aacatggcct acacaaggcc ctcggcccag gcccgaagca ggagggcagc tgggagcacc     1332

agggcaccgg gcactgccct ctcccactgc ttgacgcagg gtttcagaga aggccattca     1392

ctgccctttg gggctgggcc catggcggtg atgatttggg aagagaggag caaggcagac     1452

ggtgaggcag gagcttggag gtcagggccc acagcagccc ctccacaggg gtgccccgtc     1512

tgcaaatcag catgagaagg tcactccttg tgcagacacc acaccagcgt ctggcccacc     1572

cccgtcatgc tcagcacacg gaagcccctg cgttccagct tgtccaggac tatgcgggga     1632

gggtcatcga cgtagtattc ataactgcaa agagacagga tggggggggt gaggaggggc     1692

acacagcaag ctcctggtac aaagctagtg tctgcagcag gcagcctggc cactcttgta     1752

gtgactcaca cttgctggct gcttgctggg cgctggggta agtgcacgcc ccctgcctcc     1812

tccccttcta ggtacttcac gagctatctc atttattctt cccaacaagc tagtgaaggt     1872

gccactgttg tggccattga tagatgagaa aacagagggg ttaatcaggt tccccagcgt     1932

cccagatggt agaccatgtt agtctgacca cagccctgct gccgccctcc ctgggcttgc     1992

tccccaccca ggcttccagg taggaggagg ctgaggctgc agtgagccat gattgcacca     2052

ccgcactcca gcctgggcga cagagactcc atttcaaaaa aaaataagcc tccaggcccc     2112

tcactgccct ggctgtcctg cagttctgta gcaacaaggc tgagccccag tagctcctgg     2172

ctctgtgcgc cactccctag catggagagt gctggtagtc cttctgtcag gtttaattga     2232

tgctgaaaga ccatgaagca gacaaagggc tcaagcccca agctgggcat ggagaggcaa     2292

gtgcctcatg gcaaagggag ggggctggct tctgtccccg agccttgacc caggggctgg     2352

gatcagccct cctctttccc cgatttgaac tggcactcac tctgacaact cttttcagag     2412

agcctgtgta gcttgggttc tccctgcctc caggggtgag aggaggaatg gaagcagtag     2472

tcacagttta gacatggagg cattaggaag aatgccaagg gaaatggcta ggtccccagg     2532

cagcagccac cctggaggta ggacgcaggc tccctgctcc ctgcttctag ggcttagctt     2592

tgcgactcat gcagatcctc acgacaaaaa cctttctctc tgtgcctgtc tgtccttgat     2652

ggggtccagc ttaggagagg gcagggcaag gaacagtctg ctagtggagt cctagaccca     2712

gggaacggac tctgtttctg cggttccagt aaggatgtgg aaagctttca gagcaagcct     2772

cgtgggggag aggggggatg ttggagaggc tacagatggg accaactcct ccggagaaca     2832

gagccccagg atgcaggcag ggggctctga tgctgggccc tgtccctggg cttggaggtt     2892

gtataaaggg agcagaggca ggtctagggg ctggcaggga gaggatactg agggaggctg     2952

ctacttacaa gttgtttccc aaggctcttc tctttgaagc ccccagatgc tgcatcagct     3012

ctggatccga ctgttcatcg cccaccatag tggggcccac ctcctgcaag gtaagccaca     3072

gtggctgctt ggctggctgc caggaggagg tggaaggtct tgcctgtcct tcctcccctg     3132

cctgctagcc ctgagtaagg ttcaggtaaa ggctacagag agtagcaagg attcttaggg     3192

gctgagcaca agctgtgaag gggtggagcc catcaatgat caggaggagc aatgtaggcg     3252

ccctccctag tgccttaaag ctcagcttta gccaggcaaa gtatcacgag cctatagttc     3312

cagctactga ggctgaggtg ggaggatcgc ttgaggtggg aggagtttga ggctgcagtg     3372

agccatgatt gcaccactgc actccagcct gggtgacaga gtgagactcc atttcaaaaa     3432

aacaaaacaa aataaacatg taaatgaaag aagccagact cagatcacat taccacagaa     3492

aggtaattag tggttatcta gggctgaggg acttggggga aatcaagagt gtctgccagt     3552

gggtacaggg tttccttttg gggtattaga aatgttctaa aactgattat ggtgatggtt     3612

gcacaactct gagtacacta aagaaacaac aacactgaat tgtacacttt aaatcaaaga     3672

atttatggta tgcacattac atatcaataa agccatatct tttaagaaa                 3721


<210>  12
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Val Thr Lys Glu Leu Leu Gln Met Asp Leu Tyr Ala Leu Leu 
1               5                   10                  15      


Gly Ile Glu Glu Lys Ala Ala Asp Lys Glu Val Lys Lys Ala Tyr Arg 
            20                  25                  30          


Gln Lys Ala Leu Ser Cys His Pro Asp Lys Asn Pro Asp Asn Pro Arg 
        35                  40                  45              


Ala Ala Glu Leu Phe His Gln Leu Ser Gln Ala Leu Glu Val Leu Thr 
    50                  55                  60                  


Asp Ala Ala Ala Arg Ala Ala Tyr Asp Lys Val Arg Lys Ala Lys Lys 
65                  70                  75                  80  


Gln Ala Ala Glu Arg Thr Gln Lys Leu Asp Glu Lys Arg Lys Lys Val 
                85                  90                  95      


Lys Leu Asp Leu Glu Ala Arg Glu Arg Gln Ala Gln Ala Gln Glu Ser 
            100                 105                 110         


Glu Glu Glu Glu Glu Ser Arg Ser Thr Arg Thr Leu Glu Gln Glu Ile 
        115                 120                 125             


Glu Arg Leu Arg Glu Glu Gly Ser Arg Gln Leu Glu Glu Gln Gln Arg 
    130                 135                 140                 


Leu Ile Arg Glu Gln Ile Arg Gln Glu Arg Asp Gln Arg Leu Arg Gly 
145                 150                 155                 160 


Lys Ala Glu Asn Thr Glu Gly Gln Gly Thr Pro Lys Leu Lys Leu Lys 
                165                 170                 175     


Trp Lys Cys Lys Lys Glu Asp Glu Ser Lys Gly Gly Tyr Ser Lys Asp 
            180                 185                 190         


Val Leu Leu Arg Leu Leu Gln Lys Tyr Gly Glu Val Leu Asn Leu Val 
        195                 200                 205             


Leu Ser Ser Lys Lys Pro Gly Thr Ala Val Val Glu Phe Ala Thr Val 
    210                 215                 220                 


Lys Ala Ala Glu Leu Ala Val Gln Asn Glu Val Gly Leu Val Asp Asn 
225                 230                 235                 240 


Pro Leu Lys Ile Ser Trp Leu Glu Gly Gln Pro Gln Asp Ala Val Gly 
                245                 250                 255     


Arg Ser His Ser Gly Leu Ser Lys Gly Ser Val Leu Ser Glu Arg Asp 
            260                 265                 270         


Tyr Glu Ser Leu Val Met Met Arg Met Arg Gln Ala Ala Glu Arg Gln 
        275                 280                 285             


Gln Leu Ile Ala Arg Met Gln Gln Glu Asp Gln Glu Gly Pro Pro Thr 
    290                 295                 300                 


<210>  13
<211>  13827
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (259)..(1173)

<400>  13
acggcccggc gcgtggctcg ggctcgggcg gagctggaga cgtgtggagc tgttcgagga       60

ctcgcgggtg tgcagggatg cggtttaata ttttcatgtg attcctaaaa gaatctgagg      120

ctcaagaaaa gagggcatct taatatcctg cactttcagt cattgagggc atgatcacaa      180

agatcaaagc catttttagg cagtgcacct atgatatgtg ttttagaaat agccgttaaa      240

ctttggtttg aatgaaga atg tct ctc aat cca cct ata ttt ctc aaa cga        291
                    Met Ser Leu Asn Pro Pro Ile Phe Leu Lys Arg           
                    1               5                   10                

agt gaa gaa aat agt tca aaa ttt gtg gaa aca aaa cag tca caa act        339
Ser Glu Glu Asn Ser Ser Lys Phe Val Glu Thr Lys Gln Ser Gln Thr           
            15                  20                  25                    

act tcc ata gct tca gaa gat ccc ctt caa aac tta tgt tta gca tct        387
Thr Ser Ile Ala Ser Glu Asp Pro Leu Gln Asn Leu Cys Leu Ala Ser           
        30                  35                  40                        

caa gaa gtt ctt caa aaa gct cag caa agt ggg aga tca aaa tgt ctc        435
Gln Glu Val Leu Gln Lys Ala Gln Gln Ser Gly Arg Ser Lys Cys Leu           
    45                  50                  55                            

aaa tgt ggt ggt tcc aga atg ttc tac tgc tat aca tgt tat gtt cca        483
Lys Cys Gly Gly Ser Arg Met Phe Tyr Cys Tyr Thr Cys Tyr Val Pro           
60                  65                  70                  75            

gtt gaa aat gta cct att gaa cag att cca ctt gtg aag ctt cca ttg        531
Val Glu Asn Val Pro Ile Glu Gln Ile Pro Leu Val Lys Leu Pro Leu           
                80                  85                  90                

aag att gac atc att aaa cat cca aat gaa aca gat ggc aaa agt act        579
Lys Ile Asp Ile Ile Lys His Pro Asn Glu Thr Asp Gly Lys Ser Thr           
            95                  100                 105                   

gct ata cat gca aaa ctc tta gca cct gaa ttt gta aac att tac acg        627
Ala Ile His Ala Lys Leu Leu Ala Pro Glu Phe Val Asn Ile Tyr Thr           
        110                 115                 120                       

tat ccg tgt att cca gaa tat gaa gaa aag gac cat gaa gtt gca ctc        675
Tyr Pro Cys Ile Pro Glu Tyr Glu Glu Lys Asp His Glu Val Ala Leu           
    125                 130                 135                           

att ttt cct gga cct cag tct atc tca ata aaa gat att tct ttt cat        723
Ile Phe Pro Gly Pro Gln Ser Ile Ser Ile Lys Asp Ile Ser Phe His           
140                 145                 150                 155           

ctg caa aaa agg att caa aat aat gtt aga ggc aaa aat gat gac cct        771
Leu Gln Lys Arg Ile Gln Asn Asn Val Arg Gly Lys Asn Asp Asp Pro           
                160                 165                 170               

gac aag cca tct ttt aaa cgc aaa aga act gaa gaa caa gag ttc tgt        819
Asp Lys Pro Ser Phe Lys Arg Lys Arg Thr Glu Glu Gln Glu Phe Cys           
            175                 180                 185                   

gat ttg aat gac agc aag tgc aaa ggc aca aca ctg aaa aaa att ata        867
Asp Leu Asn Asp Ser Lys Cys Lys Gly Thr Thr Leu Lys Lys Ile Ile           
        190                 195                 200                       

ttt ata gat agc acc tgg aac caa aca aac aaa ata ttc act gat gag        915
Phe Ile Asp Ser Thr Trp Asn Gln Thr Asn Lys Ile Phe Thr Asp Glu           
    205                 210                 215                           

cga ctt caa ggg ttg tta caa gtt gag ttg aaa aca aga aaa act tgc        963
Arg Leu Gln Gly Leu Leu Gln Val Glu Leu Lys Thr Arg Lys Thr Cys           
220                 225                 230                 235           

ttt tgg cgc cat caa aaa gga aag cca gat act ttc ctt tct aca att       1011
Phe Trp Arg His Gln Lys Gly Lys Pro Asp Thr Phe Leu Ser Thr Ile           
                240                 245                 250               

gaa gcc att tac tac ttt ctg gta gac tac cat act gat ata tta aaa       1059
Glu Ala Ile Tyr Tyr Phe Leu Val Asp Tyr His Thr Asp Ile Leu Lys           
            255                 260                 265                   

gag aaa tac aga ggg caa tat gac aat ctt tta ttt ttc tat tct ttt       1107
Glu Lys Tyr Arg Gly Gln Tyr Asp Asn Leu Leu Phe Phe Tyr Ser Phe           
        270                 275                 280                       

atg tac cag ttg ata aag aat gcc aaa tgc tct gga gat aag gaa aca       1155
Met Tyr Gln Leu Ile Lys Asn Ala Lys Cys Ser Gly Asp Lys Glu Thr           
    285                 290                 295                           

gga aaa ctt aca cat tag tttttaacaa gccacttatg tctttttatt              1203
Gly Lys Leu Thr His                                                       
300                                                                       

ttgctaacat taataaactt atatttgtgc tttgtttttt cttaagaaat aatcatatat     1263

aatgcctgta agaccatttg aaaaaattcc agtttcatat atatcacttc atatttcttg     1323

aaggaaattg tatctggggg aatttttcag agatactgtt gattgaaaaa cttacttcag     1383

aagttatttg ctcagtgaaa cctcagtttc attactacat tttaatatag tgtgttatgt     1443

ctctgtgatt agatataaca tattccatta gatctaatta gctatttatt tcaacatctt     1503

tatatctttt cacctgtact catgaccacc tttagaagta aatggggtta caatctgctg     1563

gctgaaaaat aggtcataag tgatttttct tgaggttagt agcaaacata ggcagaacta     1623

gaattagaat tctggtatct agggctgttt ctttaagtcc taaggttgtt aaaagcagag     1683

actctggagc tagactacct gaatctaaat ctcagccttt ctgcttatca gccatgtcat     1743

tttcttccat ttgtacaaag caggcaatac tgagcaacta ccttatagga ataactgagt     1803

taatatctaa ggggctttca gcagtacctg aaatatagta agtgttacat atatgtttac     1863

tctttttatt ttatttggaa ttgtgaactg ataataattg aagcctacct gctagtggcc     1923

atctctgctg ccaggtgaaa agagcctgac ttagaatgaa gtcagcgaag gaaagcagag     1983

tggagagaaa aagagagact gagtcctgat gacatcattt atttacctag acctagctgc     2043

ttgtgaatag agccctactg tgctgaatag cttctgtctg ctcttttcta ttctgctccc     2103

tgctctgtga ggtaggttcc tttgctctct tgcttttggt tgggttcaac aaatgggaag     2163

caccagtggg agattagaag ttgagaggaa aatgaaatga tgttatttat ttccctggct     2223

cctttcctgc catgtcatca tcagttggct gtgttcctct actaaatagt accttatcag     2283

gaatcctatc tcttctgttc ccaagcagtt accccagtta cctcactagg tttagttcct     2343

gctccctccc tttacccctt ttcacttagg gttggtaata gcttacagtt attactagcc     2403

ccagtatagt tcactacaac ttgttgcttt acctaaaccc tgctcataca tttgtaaata     2463

ctgtagttgt tttattacac tcttctcaaa tgtccccact tgaaatagcc ttctatttct     2523

tttggggact ctgataaatt cacctgtttg ggtgaaataa tagcacattt cctgaagtat     2583

atacagtggg acacatgatg ttttatgggg gaaagagttc ttggtgaaat tagtttgctg     2643

tacattacgt tgtttccctc ccagggattc agaaggcaaa acatattaaa ggttctgaaa     2703

agtcctgaaa taaacatttt gaactttatt taagctgata tatcttaaac ttacttgaat     2763

atgtagcacc tattaacatg ccatggaaat aggacgtttg gagtattgta attaagaaca     2823

attcctatta atatacatgg ggcaactgag aattaaagag gtaagtaaat tattgataga     2883

tcatacacct agttagtagc agagcctgtt ctagaatctg gaacttctga tttggtttgg     2943

ttcagtaagg tcaccattat attatgctat tcataaaaag gaatgtggat tatataaggc     3003

ttgaacatta ttagtcttac agtcttagcc aaataaacta actggcttgc ttattttagc     3063

agttattcta caagaatgga attaaaatag attttttttt tcatgtttag aacttggccc     3123

tgggaataga ggaaggcttg aattgattta agcagggcca aagttggatt tctctaggct     3183

aaatttggac ttccctgagc caaaatctat tgcatttaac tggctttaca aaccaactaa     3243

acataacagt tcagagggaa aagaaaaaaa aaagcgagag acagagaaca attctatcac     3303

tcatttgcct ccatctctca gctggcataa gaaagatgac ccacgtactt cataagagcc     3363

taatttacag ctaaggccag ataaaatctc aggttctttt caaaagaagt tagtaatacc     3423

tattagaaca atgaattgac tatacttgtc ttagtttttt ttgtttgttt tttgtttttt     3483

gtttttttgg tgtgatagat gtaacagtgg ccctaattct ttatccttgc ttgtattcat     3543

ggtcattttt caggttcctt tgaagtactc cccccactgt gattctgggt catctgcatt     3603

cagagattta gtgcattttt acttacactt gtgcttctgc tgttgacata agaatatgca     3663

tggctgagtt agcctgctgg agcatgagac tccatggaac agagccaggt tgccctggtc     3723

accctcactg aatcttgtct agattggctg atggccagcc aaacccaaga tatgtgaatg     3783

attccagcca agatcagcag agtcatctaa ctgacaccta cctgattcca aacatgtgag     3843

caaggaatgt ctattatgcc accaatgtct tatagctatt tattgtggct atagatatct     3903

catctttgga tgcattatca gatcatcttc ttcaagtacc ttagaagatt ctcagtctca     3963

tgtttcttgg gctcttgacc acttgctttg ccttagctac cacctcatat agtaacagat     4023

taccagcagg tttgtatgat tcctctgctt gagatcaatt agccatatgt tcagaatccc     4083

tggcctataa caacacttct gtgctttaaa aaccccatgc cacaatgact gttaaaaggg     4143

ctaggcgatg tagtctggta ggtttgtgaa gttaactgtc tgaaaaactt ggatcaatgg     4203

actagaaaaa gctgctgggt aaattgctct tcttctgatg gactgtatag agacactgtt     4263

tttcatcttg cctgtccaga agcgtactct gtggccaagc aagtgtactt gccacatgat     4323

tggcagtgtc tcttcatggc ttttcatgaa acagcagcaa gtgctacaca gtaatttatc     4383

agtttgcatt tgcctcccat tattgccagc ctcacttcct ttcttcctcg ctcttaccag     4443

cctggattgt acctttaata aagtagtgga tatatttcct ttagggtctc tttttctagg     4503

gaagtcaggt gttttagtct ggatttagtt agaaaagcag catcgttaca agtattacat     4563

gaataaagaa gtttagtaaa gaaattaagg tttaccccaa tgtgagaatt actggggtaa     4623

taaaggtctg gaaggctgca gcagaagaga tttagagaag cagtgactaa ctaggtcagc     4683

cggagattct caaagtactc atgacttcat ttgtagaaac atgtatatct taagcatatc     4743

aagtgtctca ttcctctaat ctttctagga gccctttggt tcatcctgaa ggtcccccta     4803

aatcccttca gaagtcttaa aaaggagtaa atggccacac cttttatttg ttcttttctt     4863

tgaggccatg ttaatggcag tcccttgatt tggtctttgt actaggctgt ttttaatgat     4923

cacattttat ttgatgagaa acaattttat tttctagttc tgcatatcct aggttatgta     4983

tttcatttca gttccatttc catacccatt gccttaattt tgagcttgtc tgtttcttac     5043

atttctcatt ttgacagaat aagctgactg ttattaagta caatagataa ggtacctaag     5103

agcctcgaaa catcaccaaa taccatgaat gcattaggta tattttttgt cttccatgtt     5163

actggaagca ttaattatag caacttttta tctccaaata ctgacaatta aaagacccta     5223

gtgaaaactt taaccaaaca cttactgacc ctacattgaa ggccaccagc caaaaatcac     5283

cacccataca taagagccaa acatcactag acacttggtg aaatccttca aatataaaag     5343

gggaaaagga ggggagaaaa tccaaaggaa atagacaaac ggagaataat ggcaacaaaa     5403

aaaaaactgt cttcaaaata agagtatatt atattcacaa aacaagaata ggagagtgtg     5463

aaaaagaaca agcaataaaa aagatctcag aaatttaaaa agtgattgct gaaataaaaa     5523

ttaaatataa gagttgaaga taaaatatag cataagaata gaaaattctg aattccaaat     5583

acctaaggcc aatcttagtt aaaagttgta aatgcaacca taggctacat gttacattgt     5643

atttaattaa aaaccttaag aggaaaggca atagagcttg taacagctat tacccttggt     5703

tgtaaaggag aaggttggag attatttgta taccaactac ttaagtttac aaaaaataat     5763

gagcattagg tagatggaat gaaagtctat tcatacactg tatattaagc tctatataca     5823

ctgcatatca tcatcatgac attgagtttc tagctggatt gcagagatga gccaaagcgc     5883

ttctccccaa attattattt attcattttt gagacagagt ctcactcttg tctcccaggc     5943

tgcagtgcag tggtgcgatc tcagctcact acaacctcca cctcccaagt tcaagcaatt     6003

atcatgcctt agccccccga gtagctggga tcacaggcat gtgccaccac accccgctaa     6063

tttttgtatt tttagtagag atggagtttt gtcatgtttg gccagcctta tctgaaactc     6123

ctgacctcaa gtgatcctgc ctttgcttcc caaagtgctg ggattaacag gcctgagcca     6183

caacacccag cctaaattat ttttaattat gacatttttt gtattccctt gaggcactga     6243

caactatagt cttattttat atgttatagt gaatcatatt tatctcatta tatattacag     6303

aatattttgt ttgatggaga aaattcactg acctgtgctg taatgtttat accagcaatt     6363

agctgattga tttactatga cctcactctt tattcagcag ttctgccact attactagct     6423

aatccaacaa cgaggcctta ttttggcttt ctttcgaaag gtcatttctg accccagctt     6483

gaagtttgtt tattttcact tgaagagatc tctcagaaag tcaaagaaaa taggaggaaa     6543

aaaacttaag attaagggcc aatctaagag gtccttcatt tgaataatag gagtaacaga     6603

atgggaaagg cgtggaaaaa aatttgtgat ttctaaaatt gaggacatta agtcattaga     6663

gtaaaaaaaa gatgtacatt aaggcttatc atcaaggaat ttcagaacac tgtggataga     6723

aaatactaaa agatttcaaa cagaagaaat aggtcgtata tcgaccaata atcaggatat     6783

taaaggactt cttaacaaca ttggaaacta gaagacatgg ggtgatgcct ttagaacttt     6843

aagtgaaaat agttttctat ttggattcta tttttagtca tgcaattaat caagtatgaa     6903

tatagtataa agacacagaa ggtctcaaag gtattacctc ccatatattc ttgagataaa     6963

gatgcttagg agaatactga agatgttttc cagtaaaacg gagaaggaaa ccaaaaacca     7023

aaaaagagag cattaagaag tcagcaggcc aggcgcggtg gctcacgcct ctaatcccag     7083

cactttagga ggccaaggca ggtggatcgc ctgaggtctg gagtttaaga ccagcctggc     7143

taacatggcg aaactctgtc tctactaaaa atacaaaaat tagtcgggtg tgatggcatg     7203

tgtctgtaat cccagctact cgggaggctg aagcaggaga atcacttaga acctgggagg     7263

cagaagttgt agtgagccga gatggtgcca ttgcactcca gcctgggtga cagagtgaga     7323

ctccgtctca aaaaaaataa ataaaaaaat aaaaagtcag caaagggaag tttcagggtt     7383

tcaggattca ttcatccatt ctaaaaaatt ttgagtgcat actatgtgtc aaattattgt     7443

ctaggtgatg gctatagcat gccgaggtag taagtgctaa gaagaaaata aagcagagta     7503

aggaactgat agtgactggt gcaggaaagg ggtgccagtt taaatagcat ggtcagatgg     7563

aaaagcctgt gataaggtaa aattgagcag agacctaaat gagagagagt gaaccatgcg     7623

aataattaag tgaataatgt tttaattata gggaacaata tgtgtgtgtc tatatatata     7683

tatacacaca aaggtactga ggcagcagta tacttggcat gtttgaggaa taacaaggac     7743

actagtttgg aacagtgtgt gggagggaaa aaatgataga agatgacatc atagggagta     7803

atggtgtgga gccatggtaa gatgttaaga ttttactctg agtgatgaga taggaagcca     7863

tcagagaatt taagcaaatg agtgacagga tctgacttat atttttaaag gattatttgg     7923

cttctttatg aaaaatagac tgcaagagag taagaaataa aataggaaga tcaattagaa     7983

tgctatttca gtagtccatt tgagagatga tatttgcctg gacaagggtt gtgatcatgg     8043

gcgagtggta cagaatgaca agatcctgca tgtattttta aggtagagcc agtatttgca     8103

gatagtttag acattgtggt agatatgaaa atgtgctgcc tatatccccc ttctaggaag     8163

gacttgctaa ttagctgcag ggagtgtgaa gaacagaaat ccaccagtat cagcacttca     8223

tctgcaacag ctatagaaaa agcttcacct gaggttaccc tcgtcttaga tctcagggca     8283

gccctcagtg gagatgtaag gccttgctac ttcagcctca tttattacac tgtcaggcaa     8343

aaccttcctc agagctccct ctattacaac ttaatttctt cttctgccca atcctgcttc     8403

ctccccttcc cctgaaaggt gacactttct aataaacatc ttacacccca aactccatct     8463

cagcattcct ctttagagga ctcgacctgt ggtaattgtt agtaggagtg atctgagctg     8523

ccaatgagaa tcccatcaca tgtggcacat ggaacaaaag cccatggctc aaggtggtaa     8583

cttttattag tggtaaaatg agaagattta cccacggaag agaatgtgcc agcaagtgca     8643

gtatatcagg tatttgagac tcatgaagga aatagtaaat ttaagaataa cagaattgaa     8703

tggccaagtg ccactaatgc tctgtagaaa gagggcttct ttggttgcat acaaatctca     8763

tctagaattt aatagtccaa gtagccaaac tggtatttgt ccttaagaat aaatactgga     8823

agatcaagca cagaaagtct agaatagagg catgtgaatg gacatacttg tgtcaagtat     8883

gtacatgaac tgtgaaggtc tctgtattac gtgcagtgcc caccagagag cattcagtac     8943

tgaagagtct ctaaacaata aagcaaacta aacacattgc ctagttgacg tcatccttcc     9003

tgcttcagtt attcgccacc cagtgctagc acagtgggca catgaatgga atgtccactg     9063

tggaaaggat gaagactaag catagggttc agtagcttga gtttcaactt accaaggctg     9123

ccttagctgc tgctgctgtt gaatgtccaa cctacaagca acacagacaa tactgcaccc     9183

ctgatataat accattcttc aatatcaagt tggttacatt gggccccttc cacactggaa     9243

ggaccagcat ttccttgtca tagaaataga cacaatttcc agataggagt ttgcttttcc     9303

tctttgcaga gcctcagtca gtatcaccat ttgagtttac ttagtattgt attgaccagc     9363

atgcgatctc acattatatc atatcagatc cggaaaccta ttttatggaa aaccaagcgc     9423

aggagtggac ccatatccac aggatccact aataatatca cttttttcac cacttggaat     9483

ttgtcagctt gatagaacat tggaacaacc tgctgaaggt acagctgaac accagctcat     9543

aggcaaattc tacaaggata ggatgccata ctccaagata cagagtatgt actggatcaa     9603

ttatccttat atagcatgtg ccccaatatg aagaataaat gggtcttgga acccatttat     9663

tcctaggggt agatgcaaag agagtagaag aagaggtgcc tcccctccgt gccatcactt     9723

ttaatgaccc atatggtact ttgcacctct tcataactct gaactctgca gtgagaggtc     9783

ttggtcccac aaggggacac agttttgctg agagatatat aaaaaatctc actgaaaaac     9843

ataagctgca gcagctacct ggatactttc ggttccttgt gtctgtctag ggagcagcag     9903

ccaataaaag gagtcaagat cagttgaccc taatcaagag gagattggaa tcctggttac     9963

acaatctggg cagaagtaat aaatgtggtg cccaagtgat aaacctacca aattgagact    10023

aatgtgtagg tgtggcaacc catcctcaaa agggcatgat ggcctggaac tcaggcctct    10083

caaggaatgt gggtctgaat tataccagat aaaccaccag gagcagcaga ggtggtagca    10143

gaggctgagg gaaatctaga attgatagtg gaggatgagg ggatgtgaca agtattgatg    10203

gcattcccaa gccccactgc agcagcaagc actgtaattt gtcccactaa tctcccatct    10263

tctaaatttc tgagaggtca agaaaagagg tctcttgatt cctttaggaa ctgctcccta    10323

agcatacagg gagacataga tctatgtgga gcaaagggtg gattgtaata agcaaagaga    10383

tacactgcct gattcacttt aagaaaggac tgacctccca gttgcaagga atgaggtcag    10443

cagcctccaa ctgtcagctc cttcagagtc tgcttcaact gcagaaggac actgtgcttg    10503

aggtcatacc cttcccatgt ctggtgactg aagtccagct gaatgtagct gccaaagtta    10563

ccttaatgcc catgggaagc aaaaaatcaa agagtttaaa cagaattttg agaaatccca    10623

aatcagtttt ttttcagcat atgacatttt ggagtagttt gttattcagc aatagataac    10683

agaaattggt atcaggagtg gggtgttacc ataacaaaag gttaaacctt acatggtaaa    10743

aaggactttg cctctgtcat taagttaagc actttgaaat gtagagatta tcctgaatta    10803

tctaggtagg ctcaatataa gcatgagtcc ttaaaagtgg aagacggata catgagagga    10863

tgtcagaatg atgtgaaatg agaagaactc aacctgctat tgttggcttt acaggtgagt    10923

gataggaacc acaagcccca agcagcctct ggaagctgga aaaagcaaag aaacagattc    10983

tttccagagt gtccagaaag gaatgcagtt cagctaacat cttgatttta gatcagtgag    11043

atttttgtgt tggacttcta cagaactata taagaataaa ttgtgttgct taagcacact    11103

ataatacatg tggcaagaag ctgccagcta agccttgaag aatagtgaac aaactcttac    11163

tggaggatgg gaaggcagta aataaattat tgaattattg aaataaatgg aggattgagt    11223

tatgcattga cagaatgctt agcaataatt ttgcttgtct taatgtggaa cagaaaatga    11283

aacttaatag cttgtagatg tcttaaggag atttccaggt gaatgttgaa agtactgatg    11343

aacttattat ggctgcatct cataatgtac aggaagacat ttactgagtg aactaaagaa    11403

ggaactgttc aatttgaaag cagaatttag aggaaatttt tcaacctagt acttgtcatt    11463

tttttataga aaaggaaaaa tagatggaag atggagccaa aatcccagag ggaggagcca    11523

agaagcaagg agagcaatgg attaggaaac cactaccaga gggatgaact gaaccacaat    11583

caaggaatag cctcttcctt tggtgtaggg ggaccctgaa aacaatttaa ttttatgctt    11643

cctgtttcct tgtctccttt tttgaatgat agtctctgtg tggtgttcct atcctagaaa    11703

accttaactg ggacaagcta ctctcaagca tcttcacttg agaaacagta actgaggaag    11763

tttattgtat ctggacatgg tttagatgat aagattctga acttaaactt atgccataat    11823

ggagtgagac tcttagggta cagagtaagt acatttttgc atgttagtga gacaagaact    11883

gtggccgggg gcagactgtg atagtttttg aagatgtccc tcaaacaatt ccttcccttc    11943

cttggactcc tctcttcaga gggtagagtc catttccttt tccttttaat ctggattggc    12003

cttctaactc actttgacca ataaaatgtg gtaaaagtaa ggtctggcag ttttcacttt    12063

cactctcctg aaccttcata ttagaattcc aggatatcct tctagagata tccatatctc    12123

tagggacatg gtgagtccct agagacacca catggaaagg ccacctaggg aagaactgag    12183

atgccccagt caatagcact gccttagtca gtttgggcta gtataacaga aatatcatag    12243

attgagtgac tttttttctt taaaaaaatg agattgtgga acctgaaaat acagtgtagt    12303

aagagtggag agaaaggcca cctaaggaag aactgagacg tcccagtcaa tagcactgcc    12363

ttagtcagtt ggagctactg taacaaaaaa tatcatagat tgagtgactt aaacaacaga    12423

aatttatatc ttacatttct ggagactgaa aatatggaaa tccaagatca gagtttcagc    12483

atggttaggt gtttagtggg cgctcccttc ctggtttgca gacagccatc ttcctgctat    12543

atcctcacat gatgcagaga gagagaactc tggtatcttt gtccccttat aagggcacca    12603

atctcatcat ggagggtctt caacctcatg gcttcttgga accaaattac ttcccaaagt    12663

cctcacctcc aaatctagca cattgaggtt tagggcttca acatatgaat ttcagtgcat    12723

agaaagcacc aagtcctcag acaaagagaa cttgaacctt ctaactcagc ttagccatta    12783

tctgcatgca accacataag tgaccctggg taacaccatc tggagctgaa gaaccaccag    12843

ccagtacaca gaaatgagaa attttaaaat ggttgattta ggtaattaag ttttggggtg    12903

gtttattaca tagcaattga taactgatac aacagtcttt tcgttagtag aagagggggt    12963

aagaaagaaa gacttatgaa gaaaagacct gtagaaaatc gggcctacgt acctctattt    13023

ttttttcata ctcccgtgtt ttttttagtc catgctggtg gtatcctcat caatgcaatt    13083

ttctttaaaa ctctgtgagc ctttatatca gattagtcca ccccattaga acaaaagcaa    13143

cttctataaa tattgagaca ttccctttct acctttggct aagaattggg gtgctataga    13203

taattcccaa aagattatct agcctacagg gccgatgagg tatagcttga agtcattcta    13263

aagtcttcac aaaggatctt acagcctttg attttattat cactctggga ccacgtttta    13323

ctgttggcac gttcggcttt tctcatcttt tccctgagat catttatgat gtggaaatta    13383

ctttgctggc tgaagttggg aatagaaaac agtagagaat acttcaagag tattctaggt    13443

atgcactaag tttatgggaa gatatgccat ctacataatt taccttcctc tctaggccca    13503

tcataaaaat ctttgaaaaa ttaatactac attttagtat gaatataagt taaacttaga    13563

ggtgatatct attttgtggt taaatgtgtt ataaacattt atttagtgaa atacagtaca    13623

attacaacaa gcatcaatga atatttaatg agcagctgtt aatttctgaa gcagaaagaa    13683

agatgaataa aagttctggt tttactttta aaagtgaagg ctaactgtta gctcaagaaa    13743

tactttatgt ttgtcctata tgaaagtgtt gattgcacct ggttctttgc tgtaaattaa    13803

ataaaaattc aaatatttgt aaaa                                           13827


<210>  14
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Leu Asn Pro Pro Ile Phe Leu Lys Arg Ser Glu Glu Asn Ser 
1               5                   10                  15      


Ser Lys Phe Val Glu Thr Lys Gln Ser Gln Thr Thr Ser Ile Ala Ser 
            20                  25                  30          


Glu Asp Pro Leu Gln Asn Leu Cys Leu Ala Ser Gln Glu Val Leu Gln 
        35                  40                  45              


Lys Ala Gln Gln Ser Gly Arg Ser Lys Cys Leu Lys Cys Gly Gly Ser 
    50                  55                  60                  


Arg Met Phe Tyr Cys Tyr Thr Cys Tyr Val Pro Val Glu Asn Val Pro 
65                  70                  75                  80  


Ile Glu Gln Ile Pro Leu Val Lys Leu Pro Leu Lys Ile Asp Ile Ile 
                85                  90                  95      


Lys His Pro Asn Glu Thr Asp Gly Lys Ser Thr Ala Ile His Ala Lys 
            100                 105                 110         


Leu Leu Ala Pro Glu Phe Val Asn Ile Tyr Thr Tyr Pro Cys Ile Pro 
        115                 120                 125             


Glu Tyr Glu Glu Lys Asp His Glu Val Ala Leu Ile Phe Pro Gly Pro 
    130                 135                 140                 


Gln Ser Ile Ser Ile Lys Asp Ile Ser Phe His Leu Gln Lys Arg Ile 
145                 150                 155                 160 


Gln Asn Asn Val Arg Gly Lys Asn Asp Asp Pro Asp Lys Pro Ser Phe 
                165                 170                 175     


Lys Arg Lys Arg Thr Glu Glu Gln Glu Phe Cys Asp Leu Asn Asp Ser 
            180                 185                 190         


Lys Cys Lys Gly Thr Thr Leu Lys Lys Ile Ile Phe Ile Asp Ser Thr 
        195                 200                 205             


Trp Asn Gln Thr Asn Lys Ile Phe Thr Asp Glu Arg Leu Gln Gly Leu 
    210                 215                 220                 


Leu Gln Val Glu Leu Lys Thr Arg Lys Thr Cys Phe Trp Arg His Gln 
225                 230                 235                 240 


Lys Gly Lys Pro Asp Thr Phe Leu Ser Thr Ile Glu Ala Ile Tyr Tyr 
                245                 250                 255     


Phe Leu Val Asp Tyr His Thr Asp Ile Leu Lys Glu Lys Tyr Arg Gly 
            260                 265                 270         


Gln Tyr Asp Asn Leu Leu Phe Phe Tyr Ser Phe Met Tyr Gln Leu Ile 
        275                 280                 285             


Lys Asn Ala Lys Cys Ser Gly Asp Lys Glu Thr Gly Lys Leu Thr His 
    290                 295                 300                 


<210>  15
<211>  3506
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (192)..(2396)

<400>  15
aaatccagag cggcgggcac tgacgggcac ttgcaccgtg tggacagact ctccggttct       60

ggggaaatcc agtccctgtt actccatttt ggccagaaat tcaagacatt tcaggtggca      120

gaataaattc aatccttgtt tctccatctt atcgagtagt agaagttagt tacattctct      180

ttgaactcat c atg aat tcc atg aag act gaa gaa aac aag tca ttt agc       230
             Met Asn Ser Met Lys Thr Glu Glu Asn Lys Ser Phe Ser          
             1               5                   10                       

gct atg gaa gat gac cag agg act aga cct gaa gtt tca aag gat act        278
Ala Met Glu Asp Asp Gln Arg Thr Arg Pro Glu Val Ser Lys Asp Thr           
    15                  20                  25                            

gtc atg aag cag aca cat gct gac aca cct gtt gat cat tgt cta tct        326
Val Met Lys Gln Thr His Ala Asp Thr Pro Val Asp His Cys Leu Ser           
30                  35                  40                  45            

ggc ata aga aag tgt agc agc acc ttt aag ctt aaa agt gaa gtc aac        374
Gly Ile Arg Lys Cys Ser Ser Thr Phe Lys Leu Lys Ser Glu Val Asn           
                50                  55                  60                

aag cat gaa aca gcc ctt gaa atg cag aat cca aat ttg aac aat aaa        422
Lys His Glu Thr Ala Leu Glu Met Gln Asn Pro Asn Leu Asn Asn Lys           
            65                  70                  75                    

gaa tgt tgt ttc acc ttt acg ttg aat gga aac tcc aga aaa tta gac        470
Glu Cys Cys Phe Thr Phe Thr Leu Asn Gly Asn Ser Arg Lys Leu Asp           
        80                  85                  90                        

cgt agt gtg ttt aca gca tat ggt aaa ccc agc gag agt atc tac tca        518
Arg Ser Val Phe Thr Ala Tyr Gly Lys Pro Ser Glu Ser Ile Tyr Ser           
    95                  100                 105                           

gcc ctg agt gct aat gac tat ttc agt gaa agg ata aag aat cag ttt        566
Ala Leu Ser Ala Asn Asp Tyr Phe Ser Glu Arg Ile Lys Asn Gln Phe           
110                 115                 120                 125           

aat aag aac att att gtt tat gaa gaa aag aca ata gat gga cat ata        614
Asn Lys Asn Ile Ile Val Tyr Glu Glu Lys Thr Ile Asp Gly His Ile           
                130                 135                 140               

aat tta gga atg cct ctc aag tgc ctg cct agt gat tct cat ttt aaa        662
Asn Leu Gly Met Pro Leu Lys Cys Leu Pro Ser Asp Ser His Phe Lys           
            145                 150                 155                   

att aca ttt ggt caa aga aag agt agc aaa gaa gat gga cac ata tta        710
Ile Thr Phe Gly Gln Arg Lys Ser Ser Lys Glu Asp Gly His Ile Leu           
        160                 165                 170                       

cgc caa tgt gaa aat cca aac atg gaa tgc att ctt ttt cat gtt gtt        758
Arg Gln Cys Glu Asn Pro Asn Met Glu Cys Ile Leu Phe His Val Val           
    175                 180                 185                           

gct ata gga agg aca aga aag aag att gtt aag atc aac gaa ctt cat        806
Ala Ile Gly Arg Thr Arg Lys Lys Ile Val Lys Ile Asn Glu Leu His           
190                 195                 200                 205           

gaa aaa gga agt aaa ctt tgt att tat gcc ttg aag ggt gag act att        854
Glu Lys Gly Ser Lys Leu Cys Ile Tyr Ala Leu Lys Gly Glu Thr Ile           
                210                 215                 220               

gaa gga gcc tta tgc aag gat ggc cgt ttt cgg tct gac ata ggt gaa        902
Glu Gly Ala Leu Cys Lys Asp Gly Arg Phe Arg Ser Asp Ile Gly Glu           
            225                 230                 235                   

ttt gaa tgg aaa cta aag gaa ggt cat aag aaa att tat gga aaa cag        950
Phe Glu Trp Lys Leu Lys Glu Gly His Lys Lys Ile Tyr Gly Lys Gln           
        240                 245                 250                       

tcc atg gtg gat gaa gta tct gga aaa gtc tta gaa atg gac att tca        998
Ser Met Val Asp Glu Val Ser Gly Lys Val Leu Glu Met Asp Ile Ser           
    255                 260                 265                           

aaa aaa aaa gca tta caa cag aaa gat atc cat aaa aaa att aaa cag       1046
Lys Lys Lys Ala Leu Gln Gln Lys Asp Ile His Lys Lys Ile Lys Gln           
270                 275                 280                 285           

aat gaa agt gcc act gat gaa att aat cac cag agt ctg ata cag tct       1094
Asn Glu Ser Ala Thr Asp Glu Ile Asn His Gln Ser Leu Ile Gln Ser           
                290                 295                 300               

aag aaa aaa gtc cac aaa cca aag aaa gat gga gag acc aaa gat gta       1142
Lys Lys Lys Val His Lys Pro Lys Lys Asp Gly Glu Thr Lys Asp Val           
            305                 310                 315                   

gaa cac agc aga gag caa att ctc cca cct cag gat cta agc cat tat       1190
Glu His Ser Arg Glu Gln Ile Leu Pro Pro Gln Asp Leu Ser His Tyr           
        320                 325                 330                       

att aaa gat aaa act cgc cag aca att ccc agg att aga aat tat tac       1238
Ile Lys Asp Lys Thr Arg Gln Thr Ile Pro Arg Ile Arg Asn Tyr Tyr           
    335                 340                 345                           

ttt tgt agt ttg ccc cga aaa tat agg caa ata aac tca caa gtt aga       1286
Phe Cys Ser Leu Pro Arg Lys Tyr Arg Gln Ile Asn Ser Gln Val Arg           
350                 355                 360                 365           

cgg agg ccg cat ctg ggt agg cgg tat gct att aat ctg gat gtc caa       1334
Arg Arg Pro His Leu Gly Arg Arg Tyr Ala Ile Asn Leu Asp Val Gln           
                370                 375                 380               

aag gag gca att aat ctc tta aag aat tat caa acg ttg aat gaa gcc       1382
Lys Glu Ala Ile Asn Leu Leu Lys Asn Tyr Gln Thr Leu Asn Glu Ala           
            385                 390                 395                   

ata atg cat cag tat ccg aat ttt aaa gag gag gca cag tgg gta aga       1430
Ile Met His Gln Tyr Pro Asn Phe Lys Glu Glu Ala Gln Trp Val Arg           
        400                 405                 410                       

aaa tat ttt cgg gaa gaa caa aag aga atg aat ctt tca cca gct aag       1478
Lys Tyr Phe Arg Glu Glu Gln Lys Arg Met Asn Leu Ser Pro Ala Lys           
    415                 420                 425                           

caa ttc aac ata tat aaa aag gac ttc gga aaa atg act gca aat tct       1526
Gln Phe Asn Ile Tyr Lys Lys Asp Phe Gly Lys Met Thr Ala Asn Ser           
430                 435                 440                 445           

gtt tca gtt gca acc tgc gaa cag ctt aca tat tat agc aag tca gtt       1574
Val Ser Val Ala Thr Cys Glu Gln Leu Thr Tyr Tyr Ser Lys Ser Val           
                450                 455                 460               

ggg ttc atg caa tgg gac aat aat gga aac aca ggt aat gct act tgc       1622
Gly Phe Met Gln Trp Asp Asn Asn Gly Asn Thr Gly Asn Ala Thr Cys           
            465                 470                 475                   

ttt gtc ttc aat ggt ggt tat att ttc acc tgt cga cat gtt gta cat       1670
Phe Val Phe Asn Gly Gly Tyr Ile Phe Thr Cys Arg His Val Val His           
        480                 485                 490                       

ctt atg gtg ggt aaa aac aca cat cca agt ttg tgg cca gat ata att       1718
Leu Met Val Gly Lys Asn Thr His Pro Ser Leu Trp Pro Asp Ile Ile           
    495                 500                 505                           

agc aaa tgt gcg aag gta acc ttc act tat aca gag ttc tgc cct act       1766
Ser Lys Cys Ala Lys Val Thr Phe Thr Tyr Thr Glu Phe Cys Pro Thr           
510                 515                 520                 525           

cct gac aat tgg ttt tcc att gag cca tgg ctt aaa gtg tcc aat gaa       1814
Pro Asp Asn Trp Phe Ser Ile Glu Pro Trp Leu Lys Val Ser Asn Glu           
                530                 535                 540               

aat cta gat tat gcc att tta aaa cta aaa gaa aat gga aat gcg ttt       1862
Asn Leu Asp Tyr Ala Ile Leu Lys Leu Lys Glu Asn Gly Asn Ala Phe           
            545                 550                 555                   

cct cca gga cta tgg cga cag att tct cct caa cca tct act ggt ttg       1910
Pro Pro Gly Leu Trp Arg Gln Ile Ser Pro Gln Pro Ser Thr Gly Leu           
        560                 565                 570                       

att tat tta att ggt cat cct gaa ggc cag atc aag aaa ata gat ggt       1958
Ile Tyr Leu Ile Gly His Pro Glu Gly Gln Ile Lys Lys Ile Asp Gly           
    575                 580                 585                           

tgt act gtg att cct cta aac gaa cga ttg aaa aaa tat cca aac gat       2006
Cys Thr Val Ile Pro Leu Asn Glu Arg Leu Lys Lys Tyr Pro Asn Asp           
590                 595                 600                 605           

tgt caa gat ggg ttg gta gat ctc tat gat acc acc agt aat gta tac       2054
Cys Gln Asp Gly Leu Val Asp Leu Tyr Asp Thr Thr Ser Asn Val Tyr           
                610                 615                 620               

tgt atg ttt acc caa aga agt ttc cta tca gag gtt tgg aac aca cac       2102
Cys Met Phe Thr Gln Arg Ser Phe Leu Ser Glu Val Trp Asn Thr His           
            625                 630                 635                   

acg ctt agt tat gat act tgt ttc tct gat ggg tcc tca ggc tcc cca       2150
Thr Leu Ser Tyr Asp Thr Cys Phe Ser Asp Gly Ser Ser Gly Ser Pro           
        640                 645                 650                       

gtg ttt aat gca tct ggc aaa ttg gtt gct ttg cat acc ttt ggg ctt       2198
Val Phe Asn Ala Ser Gly Lys Leu Val Ala Leu His Thr Phe Gly Leu           
    655                 660                 665                           

ttt tat caa cga gga ttt aat gtg cat gcc ctt att gaa ttt ggt tat       2246
Phe Tyr Gln Arg Gly Phe Asn Val His Ala Leu Ile Glu Phe Gly Tyr           
670                 675                 680                 685           

tct atg gat tct att ctt tgt gat att aaa aag aca aat gag agc ttg       2294
Ser Met Asp Ser Ile Leu Cys Asp Ile Lys Lys Thr Asn Glu Ser Leu           
                690                 695                 700               

tat aaa tca tta aat gat gag aaa ctt gag acc tac gat gaa gag aaa       2342
Tyr Lys Ser Leu Asn Asp Glu Lys Leu Glu Thr Tyr Asp Glu Glu Lys           
            705                 710                 715                   

ggt aaa caa gag tca tca ctt caa gat cat cag att gaa ccc atg gaa       2390
Gly Lys Gln Glu Ser Ser Leu Gln Asp His Gln Ile Glu Pro Met Glu           
        720                 725                 730                       

tgt tag aaaagagatg ctgtcttcaa gaaaatatgc caataattcc tggcaaagat        2446
Cys                                                                       
                                                                          

ttcatgacaa agacacttaa agcaattgca acaaaagtga aaattggcaa atgagaccta     2506

attaaatctt ctgcacagca aaagaaacta tcaacagggt aaacacacaa cctacggaat     2566

gggagaaaat atttgcaaac tatgcataca gcaaagatct aatattcaga atccattagg     2626

aacttaaaca gattaacaag caaaaaaaac aagcaacccc attaaaaagt gggcaaagga     2686

catgaacaaa cacttttcaa aagaagatat acacatggcc aacaaggata tgaaaaaata     2746

cctgatatca ctaatcatta gagaaatgca aatcaaaaaa atgccatcac actaatcaga     2806

atggctgtta ttaaaatgcc aaaaaattac agatgctggc gaggttgcag agaaagggga     2866

atgcttatac actgctagtg ggaaaataaa ttagttcagc cattgtggaa agcagttggg     2926

tgatttctaa aagaacttaa aacagctacc attcaagcca gcaatctcat gactgggtat     2986

atgtccaaag gaatataaat tgttctacca taaagacatg cacatatatg ttcactgcag     3046

cactattcac aatagcaaaa catgaaatca acctaaatgc ccatcaatgg tagactggat     3106

aaagaaaatg tgacacatat acaccatagc atactacaca gccataaaaa agtacaagat     3166

catgtgcttt gcagcaacat ggatggaact gaaggtcatt atcctaagcg aactaatgca     3226

ggaacagaaa gccaagtacc acatgttctc tcataagtgg aagctaaata ttgagtacac     3286

atggacacaa agaagaaaac aacagatatg gggcctactt gagggtggag ggtgggagga     3346

gggtgaagac tgaaaaactg cctatggggt actatgctta ttacctgggt gatgaaataa     3406

tctgaacaca aaaccctggt gacatgcagt ttacctatat aacaaaactg cacatggact     3466

cttaaaccta aataaaagtt taaaatatat ataatgccaa                           3506


<210>  16
<211>  734
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Asn Ser Met Lys Thr Glu Glu Asn Lys Ser Phe Ser Ala Met Glu 
1               5                   10                  15      


Asp Asp Gln Arg Thr Arg Pro Glu Val Ser Lys Asp Thr Val Met Lys 
            20                  25                  30          


Gln Thr His Ala Asp Thr Pro Val Asp His Cys Leu Ser Gly Ile Arg 
        35                  40                  45              


Lys Cys Ser Ser Thr Phe Lys Leu Lys Ser Glu Val Asn Lys His Glu 
    50                  55                  60                  


Thr Ala Leu Glu Met Gln Asn Pro Asn Leu Asn Asn Lys Glu Cys Cys 
65                  70                  75                  80  


Phe Thr Phe Thr Leu Asn Gly Asn Ser Arg Lys Leu Asp Arg Ser Val 
                85                  90                  95      


Phe Thr Ala Tyr Gly Lys Pro Ser Glu Ser Ile Tyr Ser Ala Leu Ser 
            100                 105                 110         


Ala Asn Asp Tyr Phe Ser Glu Arg Ile Lys Asn Gln Phe Asn Lys Asn 
        115                 120                 125             


Ile Ile Val Tyr Glu Glu Lys Thr Ile Asp Gly His Ile Asn Leu Gly 
    130                 135                 140                 


Met Pro Leu Lys Cys Leu Pro Ser Asp Ser His Phe Lys Ile Thr Phe 
145                 150                 155                 160 


Gly Gln Arg Lys Ser Ser Lys Glu Asp Gly His Ile Leu Arg Gln Cys 
                165                 170                 175     


Glu Asn Pro Asn Met Glu Cys Ile Leu Phe His Val Val Ala Ile Gly 
            180                 185                 190         


Arg Thr Arg Lys Lys Ile Val Lys Ile Asn Glu Leu His Glu Lys Gly 
        195                 200                 205             


Ser Lys Leu Cys Ile Tyr Ala Leu Lys Gly Glu Thr Ile Glu Gly Ala 
    210                 215                 220                 


Leu Cys Lys Asp Gly Arg Phe Arg Ser Asp Ile Gly Glu Phe Glu Trp 
225                 230                 235                 240 


Lys Leu Lys Glu Gly His Lys Lys Ile Tyr Gly Lys Gln Ser Met Val 
                245                 250                 255     


Asp Glu Val Ser Gly Lys Val Leu Glu Met Asp Ile Ser Lys Lys Lys 
            260                 265                 270         


Ala Leu Gln Gln Lys Asp Ile His Lys Lys Ile Lys Gln Asn Glu Ser 
        275                 280                 285             


Ala Thr Asp Glu Ile Asn His Gln Ser Leu Ile Gln Ser Lys Lys Lys 
    290                 295                 300                 


Val His Lys Pro Lys Lys Asp Gly Glu Thr Lys Asp Val Glu His Ser 
305                 310                 315                 320 


Arg Glu Gln Ile Leu Pro Pro Gln Asp Leu Ser His Tyr Ile Lys Asp 
                325                 330                 335     


Lys Thr Arg Gln Thr Ile Pro Arg Ile Arg Asn Tyr Tyr Phe Cys Ser 
            340                 345                 350         


Leu Pro Arg Lys Tyr Arg Gln Ile Asn Ser Gln Val Arg Arg Arg Pro 
        355                 360                 365             


His Leu Gly Arg Arg Tyr Ala Ile Asn Leu Asp Val Gln Lys Glu Ala 
    370                 375                 380                 


Ile Asn Leu Leu Lys Asn Tyr Gln Thr Leu Asn Glu Ala Ile Met His 
385                 390                 395                 400 


Gln Tyr Pro Asn Phe Lys Glu Glu Ala Gln Trp Val Arg Lys Tyr Phe 
                405                 410                 415     


Arg Glu Glu Gln Lys Arg Met Asn Leu Ser Pro Ala Lys Gln Phe Asn 
            420                 425                 430         


Ile Tyr Lys Lys Asp Phe Gly Lys Met Thr Ala Asn Ser Val Ser Val 
        435                 440                 445             


Ala Thr Cys Glu Gln Leu Thr Tyr Tyr Ser Lys Ser Val Gly Phe Met 
    450                 455                 460                 


Gln Trp Asp Asn Asn Gly Asn Thr Gly Asn Ala Thr Cys Phe Val Phe 
465                 470                 475                 480 


Asn Gly Gly Tyr Ile Phe Thr Cys Arg His Val Val His Leu Met Val 
                485                 490                 495     


Gly Lys Asn Thr His Pro Ser Leu Trp Pro Asp Ile Ile Ser Lys Cys 
            500                 505                 510         


Ala Lys Val Thr Phe Thr Tyr Thr Glu Phe Cys Pro Thr Pro Asp Asn 
        515                 520                 525             


Trp Phe Ser Ile Glu Pro Trp Leu Lys Val Ser Asn Glu Asn Leu Asp 
    530                 535                 540                 


Tyr Ala Ile Leu Lys Leu Lys Glu Asn Gly Asn Ala Phe Pro Pro Gly 
545                 550                 555                 560 


Leu Trp Arg Gln Ile Ser Pro Gln Pro Ser Thr Gly Leu Ile Tyr Leu 
                565                 570                 575     


Ile Gly His Pro Glu Gly Gln Ile Lys Lys Ile Asp Gly Cys Thr Val 
            580                 585                 590         


Ile Pro Leu Asn Glu Arg Leu Lys Lys Tyr Pro Asn Asp Cys Gln Asp 
        595                 600                 605             


Gly Leu Val Asp Leu Tyr Asp Thr Thr Ser Asn Val Tyr Cys Met Phe 
    610                 615                 620                 


Thr Gln Arg Ser Phe Leu Ser Glu Val Trp Asn Thr His Thr Leu Ser 
625                 630                 635                 640 


Tyr Asp Thr Cys Phe Ser Asp Gly Ser Ser Gly Ser Pro Val Phe Asn 
                645                 650                 655     


Ala Ser Gly Lys Leu Val Ala Leu His Thr Phe Gly Leu Phe Tyr Gln 
            660                 665                 670         


Arg Gly Phe Asn Val His Ala Leu Ile Glu Phe Gly Tyr Ser Met Asp 
        675                 680                 685             


Ser Ile Leu Cys Asp Ile Lys Lys Thr Asn Glu Ser Leu Tyr Lys Ser 
    690                 695                 700                 


Leu Asn Asp Glu Lys Leu Glu Thr Tyr Asp Glu Glu Lys Gly Lys Gln 
705                 710                 715                 720 


Glu Ser Ser Leu Gln Asp His Gln Ile Glu Pro Met Glu Cys 
                725                 730                 


<210>  17
<211>  2742
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (37)..(1476)

<400>  17
ctgtttctgg agagagctgt ttgaatttgg aaaccc atg ttg gct gtc cca aat         54
                                        Met Leu Ala Val Pro Asn           
                                        1               5                 

atg aga ttt ggc atc ttt ctt ttg tgg tgg gga tgg gtt ttg gcc act        102
Met Arg Phe Gly Ile Phe Leu Leu Trp Trp Gly Trp Val Leu Ala Thr           
            10                  15                  20                    

gaa agc aga atg cac tgg ccc gga aga gaa gtc cac gag atg tct aag        150
Glu Ser Arg Met His Trp Pro Gly Arg Glu Val His Glu Met Ser Lys           
        25                  30                  35                        

aaa ggc agg ccc caa aga caa aga cga gaa gta cat gaa gat gcc cac        198
Lys Gly Arg Pro Gln Arg Gln Arg Arg Glu Val His Glu Asp Ala His           
    40                  45                  50                            

aag caa gtc agc cca att ctg aga cga agt cct gac atc acc aaa tcg        246
Lys Gln Val Ser Pro Ile Leu Arg Arg Ser Pro Asp Ile Thr Lys Ser           
55                  60                  65                  70            

cct ctg aca aag tca gaa cag ctt ctg agg ata gat gac cat gat ttc        294
Pro Leu Thr Lys Ser Glu Gln Leu Leu Arg Ile Asp Asp His Asp Phe           
                75                  80                  85                

agc atg agg cct ggc ttt gga ggc cct gcc att cct gtt ggt gtg gat        342
Ser Met Arg Pro Gly Phe Gly Gly Pro Ala Ile Pro Val Gly Val Asp           
            90                  95                  100                   

gtg cag gtg gag agt ttg gat agc atc tca gag gtt gac atg gac ttt        390
Val Gln Val Glu Ser Leu Asp Ser Ile Ser Glu Val Asp Met Asp Phe           
        105                 110                 115                       

acg atg acc ctc tac ctg agg cac tac tgg aag gac gag agg ctg tct        438
Thr Met Thr Leu Tyr Leu Arg His Tyr Trp Lys Asp Glu Arg Leu Ser           
    120                 125                 130                           

ttt cca agc acc aac aac ctc agc atg acg ttt gac ggc cgg ctg gtc        486
Phe Pro Ser Thr Asn Asn Leu Ser Met Thr Phe Asp Gly Arg Leu Val           
135                 140                 145                 150           

aag aag atc tgg gtc cct gac atg ttt ttc gtg cac tcc aaa cgc tcc        534
Lys Lys Ile Trp Val Pro Asp Met Phe Phe Val His Ser Lys Arg Ser           
                155                 160                 165               

ttc atc cac gac acc acc aca gac aac gtc atg ttg cgg gtc cag cct        582
Phe Ile His Asp Thr Thr Thr Asp Asn Val Met Leu Arg Val Gln Pro           
            170                 175                 180                   

gat ggg aaa gtg ctc tat agt ctc agg gtt aca gta act gca atg tgc        630
Asp Gly Lys Val Leu Tyr Ser Leu Arg Val Thr Val Thr Ala Met Cys           
        185                 190                 195                       

aac atg gac ttc agc cga ttt ccc ttg gac aca caa acg tgc tct ctt        678
Asn Met Asp Phe Ser Arg Phe Pro Leu Asp Thr Gln Thr Cys Ser Leu           
    200                 205                 210                           

gaa att gaa agc tat gcc tat aca gaa gat gac ctc atg ctg tac tgg        726
Glu Ile Glu Ser Tyr Ala Tyr Thr Glu Asp Asp Leu Met Leu Tyr Trp           
215                 220                 225                 230           

aaa aag ggc aat gac tcc tta aag aca gat gaa cgg atc tca ctc tcc        774
Lys Lys Gly Asn Asp Ser Leu Lys Thr Asp Glu Arg Ile Ser Leu Ser           
                235                 240                 245               

cag ttc ctc att cag gaa ttc cac acc acc acc aaa ctg gct ttc tac        822
Gln Phe Leu Ile Gln Glu Phe His Thr Thr Thr Lys Leu Ala Phe Tyr           
            250                 255                 260                   

agc agc aca ggc tgg tac aac cgt ctc tac att aat ttc acg ttg cgt        870
Ser Ser Thr Gly Trp Tyr Asn Arg Leu Tyr Ile Asn Phe Thr Leu Arg           
        265                 270                 275                       

cgc cac atc ttc ttc ttc ttg ctc caa act tat ttc ccc gct acc ctg        918
Arg His Ile Phe Phe Phe Leu Leu Gln Thr Tyr Phe Pro Ala Thr Leu           
    280                 285                 290                           

atg gtc atg ctg tcc tgg gtg tcc ttc tgg atc gac cgc aga gcc gtg        966
Met Val Met Leu Ser Trp Val Ser Phe Trp Ile Asp Arg Arg Ala Val           
295                 300                 305                 310           

cct gcc aga gtc ccc tta ggt atc aca acg gtg ctg acc atg tcc acc       1014
Pro Ala Arg Val Pro Leu Gly Ile Thr Thr Val Leu Thr Met Ser Thr           
                315                 320                 325               

atc atc acg ggc gtg aat gcc tcc atg ccg cgc gtc tcc tac atc aag       1062
Ile Ile Thr Gly Val Asn Ala Ser Met Pro Arg Val Ser Tyr Ile Lys           
            330                 335                 340                   

gcc gtg gac atc tac ctc tgg gtc agc ttt gtg ttc gtg ttc ctc tcg       1110
Ala Val Asp Ile Tyr Leu Trp Val Ser Phe Val Phe Val Phe Leu Ser           
        345                 350                 355                       

gtg ctg gag tat gcg gcc gtc aac tac ctg acc act gtg cag gag agg       1158
Val Leu Glu Tyr Ala Ala Val Asn Tyr Leu Thr Thr Val Gln Glu Arg           
    360                 365                 370                           

aag gaa cag aag ctg cgg gag aag ctt ccc tgc acc agc gga tta cct       1206
Lys Glu Gln Lys Leu Arg Glu Lys Leu Pro Cys Thr Ser Gly Leu Pro           
375                 380                 385                 390           

ccg ccc cgc act gcg atg ctg gac ggc aac tac agt gat ggg gag gtg       1254
Pro Pro Arg Thr Ala Met Leu Asp Gly Asn Tyr Ser Asp Gly Glu Val           
                395                 400                 405               

aat gac ctg gac aac tac atg cca gag aat gga gag aag ccc gac agg       1302
Asn Asp Leu Asp Asn Tyr Met Pro Glu Asn Gly Glu Lys Pro Asp Arg           
            410                 415                 420                   

atg atg gtg cag ctg acc ctg gcc tca gag agg agc tcc cca cag agg       1350
Met Met Val Gln Leu Thr Leu Ala Ser Glu Arg Ser Ser Pro Gln Arg           
        425                 430                 435                       

aaa agt cag aga agc agc tat gtg agc atg aga atc gac acc cac gcc       1398
Lys Ser Gln Arg Ser Ser Tyr Val Ser Met Arg Ile Asp Thr His Ala           
    440                 445                 450                           

att gat aaa tac tcc agg atc atc ttt cca gca gca tac att tta ttc       1446
Ile Asp Lys Tyr Ser Arg Ile Ile Phe Pro Ala Ala Tyr Ile Leu Phe           
455                 460                 465                 470           

aat tta ata tac tgg tct att ttc tcc tag atgcttgtaa ttctacaaat         1496
Asn Leu Ile Tyr Trp Ser Ile Phe Ser                                       
                475                                                       

ttcacatttc catggcatgc actacagaaa taactgtata atgaaaaagt atttaaggat     1556

atggttaaaa aaaaatccca ggacccaccc atgttttcac tatcccttct gcagctttcc     1616

aaagctacat tgacgagaca cttactggtt taatttgcac ttattaacca tctattgaat     1676

acacagcatt atattaggtg ctgcaggaaa tacgacactg tagcgactga tgttagttgt     1736

tacccagatc ccctggaaaa gcacactacc agtgttgtgg gcacatttag ttccacccgt     1796

tagacccttg atgctattca catgaataat ttattttcct caagtgtcat tacattgttc     1856

aggctacgtg aacttggaag cacctacagg ccatttgcat gaaattcaca tgcacctaaa     1916

tcctcacttt gacagaaact catgcttcag tttataacct attacctatt ttgtatgcga     1976

ctccacctcc gcatgtttat tttaataaaa ggcaatgata acattcacat tatttttctt     2036

tatatgctgt ggttcacagg ctttacccct tcacaagaaa agctctttag attggcgcaa     2096

ttgcttctga ttttggtgaa attttccctg gtagggaaac tttgaagata agagtacaca     2156

catgcatttt gtctgttgtg tcatagaggt aactaggcta gaaaatttgt gtttaaatgt     2216

tccctatttt atataatcac cacttcatgt ttcttcttct tggagcatgt ccttgttcaa     2276

agagaagtgc tttctcagtg atgtgatatc ttcactgagg aacttgggta gagaatgatt     2336

tcttctgcat aaacacttca aggaaataca taatttggga ctacttgtaa ctcattagaa     2396

tgagaaatac tcacatggtt tcttaagaga aaaagaacat cggaaagcaa aataaatggg     2456

aagatatcac tggacatctg catttatact cgaaatacca gcattttcta tggaccagaa     2516

aactgccatc acctagacca cacagcccag ataccaggca gacggatggc ccaatggcaa     2576

ctgatgtcag ggcatggggt aaaggagagg gttctaatct ggtgtatcac ttaaaaacag     2636

ttatttatat tatatatctg ctatatagat caacctccac caaacttacc caaacagcat     2696

ttgttttatt tgaaactcac tttaataaag tgaattatat acacaa                    2742


<210>  18
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Leu Ala Val Pro Asn Met Arg Phe Gly Ile Phe Leu Leu Trp Trp 
1               5                   10                  15      


Gly Trp Val Leu Ala Thr Glu Ser Arg Met His Trp Pro Gly Arg Glu 
            20                  25                  30          


Val His Glu Met Ser Lys Lys Gly Arg Pro Gln Arg Gln Arg Arg Glu 
        35                  40                  45              


Val His Glu Asp Ala His Lys Gln Val Ser Pro Ile Leu Arg Arg Ser 
    50                  55                  60                  


Pro Asp Ile Thr Lys Ser Pro Leu Thr Lys Ser Glu Gln Leu Leu Arg 
65                  70                  75                  80  


Ile Asp Asp His Asp Phe Ser Met Arg Pro Gly Phe Gly Gly Pro Ala 
                85                  90                  95      


Ile Pro Val Gly Val Asp Val Gln Val Glu Ser Leu Asp Ser Ile Ser 
            100                 105                 110         


Glu Val Asp Met Asp Phe Thr Met Thr Leu Tyr Leu Arg His Tyr Trp 
        115                 120                 125             


Lys Asp Glu Arg Leu Ser Phe Pro Ser Thr Asn Asn Leu Ser Met Thr 
    130                 135                 140                 


Phe Asp Gly Arg Leu Val Lys Lys Ile Trp Val Pro Asp Met Phe Phe 
145                 150                 155                 160 


Val His Ser Lys Arg Ser Phe Ile His Asp Thr Thr Thr Asp Asn Val 
                165                 170                 175     


Met Leu Arg Val Gln Pro Asp Gly Lys Val Leu Tyr Ser Leu Arg Val 
            180                 185                 190         


Thr Val Thr Ala Met Cys Asn Met Asp Phe Ser Arg Phe Pro Leu Asp 
        195                 200                 205             


Thr Gln Thr Cys Ser Leu Glu Ile Glu Ser Tyr Ala Tyr Thr Glu Asp 
    210                 215                 220                 


Asp Leu Met Leu Tyr Trp Lys Lys Gly Asn Asp Ser Leu Lys Thr Asp 
225                 230                 235                 240 


Glu Arg Ile Ser Leu Ser Gln Phe Leu Ile Gln Glu Phe His Thr Thr 
                245                 250                 255     


Thr Lys Leu Ala Phe Tyr Ser Ser Thr Gly Trp Tyr Asn Arg Leu Tyr 
            260                 265                 270         


Ile Asn Phe Thr Leu Arg Arg His Ile Phe Phe Phe Leu Leu Gln Thr 
        275                 280                 285             


Tyr Phe Pro Ala Thr Leu Met Val Met Leu Ser Trp Val Ser Phe Trp 
    290                 295                 300                 


Ile Asp Arg Arg Ala Val Pro Ala Arg Val Pro Leu Gly Ile Thr Thr 
305                 310                 315                 320 


Val Leu Thr Met Ser Thr Ile Ile Thr Gly Val Asn Ala Ser Met Pro 
                325                 330                 335     


Arg Val Ser Tyr Ile Lys Ala Val Asp Ile Tyr Leu Trp Val Ser Phe 
            340                 345                 350         


Val Phe Val Phe Leu Ser Val Leu Glu Tyr Ala Ala Val Asn Tyr Leu 
        355                 360                 365             


Thr Thr Val Gln Glu Arg Lys Glu Gln Lys Leu Arg Glu Lys Leu Pro 
    370                 375                 380                 


Cys Thr Ser Gly Leu Pro Pro Pro Arg Thr Ala Met Leu Asp Gly Asn 
385                 390                 395                 400 


Tyr Ser Asp Gly Glu Val Asn Asp Leu Asp Asn Tyr Met Pro Glu Asn 
                405                 410                 415     


Gly Glu Lys Pro Asp Arg Met Met Val Gln Leu Thr Leu Ala Ser Glu 
            420                 425                 430         


Arg Ser Ser Pro Gln Arg Lys Ser Gln Arg Ser Ser Tyr Val Ser Met 
        435                 440                 445             


Arg Ile Asp Thr His Ala Ile Asp Lys Tyr Ser Arg Ile Ile Phe Pro 
    450                 455                 460                 


Ala Ala Tyr Ile Leu Phe Asn Leu Ile Tyr Trp Ser Ile Phe Ser 
465                 470                 475                 


<210>  19
<211>  2576
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (239)..(1600)

<400>  19
acatacactc ccaaacctca acacccaggc gcctcctggg cctctcctag gttgggctgc       60

tccagcaagt ttccatgaaa gcacctgaaa tactaagtta ccttcgcgag gagaactcga      120

gtgagataaa atcgtgcgcc cacgcaggtg agtttgcagc caagaatttt ggacgctgct      180

gggaggagaa agggaagttg agaaagtctt tggacctggt agcctggtgc tctttctc        238

atg gct tca ccc agc ctc ccg ggc agt gac tgc tcc caa atc att gat        286
Met Ala Ser Pro Ser Leu Pro Gly Ser Asp Cys Ser Gln Ile Ile Asp           
1               5                   10                  15                

cac agt cat gtc ccc gag ttt gag gtg gcc acc tgg atc aaa atc acc        334
His Ser His Val Pro Glu Phe Glu Val Ala Thr Trp Ile Lys Ile Thr           
            20                  25                  30                    

ctt att ctg gtg tac ctg atc atc ttc gtg atg ggc ctt ctg ggg aac        382
Leu Ile Leu Val Tyr Leu Ile Ile Phe Val Met Gly Leu Leu Gly Asn           
        35                  40                  45                        

agc gcc acc att cgg gtc acc cag gtg ctg cag aag aaa gga tac ttg        430
Ser Ala Thr Ile Arg Val Thr Gln Val Leu Gln Lys Lys Gly Tyr Leu           
    50                  55                  60                            

cag aag gag gtg aca gac cac atg gtg agt ttg gct tgc tcg gac atc        478
Gln Lys Glu Val Thr Asp His Met Val Ser Leu Ala Cys Ser Asp Ile           
65                  70                  75                  80            

ttg gtg ttc ctc atc ggc atg ccc atg gag ttc tac agc atc atc tgg        526
Leu Val Phe Leu Ile Gly Met Pro Met Glu Phe Tyr Ser Ile Ile Trp           
                85                  90                  95                

aat ccc ctg acc acg tcc agc tac acc ctg tcc tgc aag ctg cac act        574
Asn Pro Leu Thr Thr Ser Ser Tyr Thr Leu Ser Cys Lys Leu His Thr           
            100                 105                 110                   

ttc ctc ttc gag gcc tgc agc tac gct acg ctg ctg cac gtg ctg aca        622
Phe Leu Phe Glu Ala Cys Ser Tyr Ala Thr Leu Leu His Val Leu Thr           
        115                 120                 125                       

ctc agc ttt gag cgc tac atc gcc atc tgt cac ccc ttc agg tac aag        670
Leu Ser Phe Glu Arg Tyr Ile Ala Ile Cys His Pro Phe Arg Tyr Lys           
    130                 135                 140                           

gct gtg tcg gga cct tgc cag gtg aag ctg ctg att ggc ttc gtc tgg        718
Ala Val Ser Gly Pro Cys Gln Val Lys Leu Leu Ile Gly Phe Val Trp           
145                 150                 155                 160           

gtc acc tcc gcc ctg gtg gca ctg ccc ttg ctg ttt gcc atg ggt act        766
Val Thr Ser Ala Leu Val Ala Leu Pro Leu Leu Phe Ala Met Gly Thr           
                165                 170                 175               

gag tac ccc ctg gtg aac gtg ccc agc cac cgg ggt ctc act tgc aac        814
Glu Tyr Pro Leu Val Asn Val Pro Ser His Arg Gly Leu Thr Cys Asn           
            180                 185                 190                   

cgc tcc agc acc cgc cac cac gag cag ccc gag acc tcc aat atg tcc        862
Arg Ser Ser Thr Arg His His Glu Gln Pro Glu Thr Ser Asn Met Ser           
        195                 200                 205                       

atc tgt acc aac ctc tcc agc cgc tgg acc gtg ttc cag tcc agc atc        910
Ile Cys Thr Asn Leu Ser Ser Arg Trp Thr Val Phe Gln Ser Ser Ile           
    210                 215                 220                           

ttc ggc gcc ttc gtg gtc tac ctc gtg gtc ctg ctc tcc gta gcc ttc        958
Phe Gly Ala Phe Val Val Tyr Leu Val Val Leu Leu Ser Val Ala Phe           
225                 230                 235                 240           

atg tgc tgg aac atg atg cag gtg ctc atg aaa agc cag aag ggc tcg       1006
Met Cys Trp Asn Met Met Gln Val Leu Met Lys Ser Gln Lys Gly Ser           
                245                 250                 255               

ctg gcc ggg ggc acg cgg cct ccg cag ctg agg aag tcc gag agc gaa       1054
Leu Ala Gly Gly Thr Arg Pro Pro Gln Leu Arg Lys Ser Glu Ser Glu           
            260                 265                 270                   

gag agc agg acc gcc agg agg cag acc atc atc ttc ctg agg ctg att       1102
Glu Ser Arg Thr Ala Arg Arg Gln Thr Ile Ile Phe Leu Arg Leu Ile           
        275                 280                 285                       

gtt gtg aca ttg gcc gta tgc tgg atg ccc aac cag att cgg agg atc       1150
Val Val Thr Leu Ala Val Cys Trp Met Pro Asn Gln Ile Arg Arg Ile           
    290                 295                 300                           

atg gct gcg gcc aaa ccc aag cac gac tgg acg agg tcc tac ttc cgg       1198
Met Ala Ala Ala Lys Pro Lys His Asp Trp Thr Arg Ser Tyr Phe Arg           
305                 310                 315                 320           

gcg tac atg atc ctc ctc ccc ttc tcg gag acg ttt ttc tac ctc agc       1246
Ala Tyr Met Ile Leu Leu Pro Phe Ser Glu Thr Phe Phe Tyr Leu Ser           
                325                 330                 335               

tcg gtc atc aac ccg ctc ctg tac acg gtg tcc tcg cag cag ttt cgg       1294
Ser Val Ile Asn Pro Leu Leu Tyr Thr Val Ser Ser Gln Gln Phe Arg           
            340                 345                 350                   

cgg gtg ttc gtg cag gtg ctg tgc tgc cgc ctg tcg ctg cag cac gcc       1342
Arg Val Phe Val Gln Val Leu Cys Cys Arg Leu Ser Leu Gln His Ala           
        355                 360                 365                       

aac cac gag aag cgc ctg cgc gta cat gcg cac tcc acc acc gac agc       1390
Asn His Glu Lys Arg Leu Arg Val His Ala His Ser Thr Thr Asp Ser           
    370                 375                 380                           

gcc cgc ttt gtg cag cgc ccg ttg ctc ttc gcg tcc cgg cgc cag tcc       1438
Ala Arg Phe Val Gln Arg Pro Leu Leu Phe Ala Ser Arg Arg Gln Ser           
385                 390                 395                 400           

tct gca agg aga act gag aag att ttc tta agc act ttt cag agc gag       1486
Ser Ala Arg Arg Thr Glu Lys Ile Phe Leu Ser Thr Phe Gln Ser Glu           
                405                 410                 415               

gcc gag ccc cag tct aag tcc cag tca ttg agt ctc gag tca cta gag       1534
Ala Glu Pro Gln Ser Lys Ser Gln Ser Leu Ser Leu Glu Ser Leu Glu           
            420                 425                 430                   

ccc aac tca ggc gcg aaa cca gcc aat tct gct gca gag aat ggt ttt       1582
Pro Asn Ser Gly Ala Lys Pro Ala Asn Ser Ala Ala Glu Asn Gly Phe           
        435                 440                 445                       

cag gag cat gaa gtt tga atgtcaagcg agggagcctt gagtgggaac              1630
Gln Glu His Glu Val                                                       
    450                                                                   

tggccctcca gccctaagaa aacgtcactc tcactctgca gtctcaaact atgcccccat     1690

cagggatgga atggacactg gaggctttac aaaaggcaga tgcccacctc agtgacttct     1750

aaggactgac tctgccagcc tggccttgac tccggttaca cagacatggg ggtgaacttt     1810

cactccacct ccttccttca agtacatact gaaaattcag tcaggctgaa tttattcaga     1870

atgctttacc gagctctttc attatttgca caggaacaaa agagaacacg gactcccgct     1930

ccctacccag aataaaagga cacccagaag aaactcactc agggaggtgg ggggttgggg     1990

gcgagggctg gaagaacaat gcaggagggg gtggcatctc cttcagcttc agcagtgtgc     2050

cgagaagagg gctaatttga ggaacaggat ggtggtgcgg agccctggcc tgagggccga     2110

ggcagaactt ccccttttct tgggccttgg cccgttacaa agaggggtgt tgcagcagct     2170

gatgcaaact gagttcagtt tccctgggga gcagaaggac tggtacccgg cagaggcgat     2230

gagacaggcc gctgatgatg cacaggactt gcggtacatg atccctgtaa cacagaccca     2290

aaggagctga gttaacgtgc accggcaaaa gaatagctgt ccctctcagc ccaaatccaa     2350

acggacagct cttccttact cctcccacag cccagagact aggtgaggtc agggaagtgc     2410

ttcggattgt ctcattgata ttcaagatag atggtgaaag agacaggcac tatttcatta     2470

gttttaacaa aactgttcca aaagcgattt gagatgccaa tacctgtgaa tacctgttaa     2530

taaagagctg ttaaatagac ttatttacat tttaagtcag agttca                    2576


<210>  20
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Ser Pro Ser Leu Pro Gly Ser Asp Cys Ser Gln Ile Ile Asp 
1               5                   10                  15      


His Ser His Val Pro Glu Phe Glu Val Ala Thr Trp Ile Lys Ile Thr 
            20                  25                  30          


Leu Ile Leu Val Tyr Leu Ile Ile Phe Val Met Gly Leu Leu Gly Asn 
        35                  40                  45              


Ser Ala Thr Ile Arg Val Thr Gln Val Leu Gln Lys Lys Gly Tyr Leu 
    50                  55                  60                  


Gln Lys Glu Val Thr Asp His Met Val Ser Leu Ala Cys Ser Asp Ile 
65                  70                  75                  80  


Leu Val Phe Leu Ile Gly Met Pro Met Glu Phe Tyr Ser Ile Ile Trp 
                85                  90                  95      


Asn Pro Leu Thr Thr Ser Ser Tyr Thr Leu Ser Cys Lys Leu His Thr 
            100                 105                 110         


Phe Leu Phe Glu Ala Cys Ser Tyr Ala Thr Leu Leu His Val Leu Thr 
        115                 120                 125             


Leu Ser Phe Glu Arg Tyr Ile Ala Ile Cys His Pro Phe Arg Tyr Lys 
    130                 135                 140                 


Ala Val Ser Gly Pro Cys Gln Val Lys Leu Leu Ile Gly Phe Val Trp 
145                 150                 155                 160 


Val Thr Ser Ala Leu Val Ala Leu Pro Leu Leu Phe Ala Met Gly Thr 
                165                 170                 175     


Glu Tyr Pro Leu Val Asn Val Pro Ser His Arg Gly Leu Thr Cys Asn 
            180                 185                 190         


Arg Ser Ser Thr Arg His His Glu Gln Pro Glu Thr Ser Asn Met Ser 
        195                 200                 205             


Ile Cys Thr Asn Leu Ser Ser Arg Trp Thr Val Phe Gln Ser Ser Ile 
    210                 215                 220                 


Phe Gly Ala Phe Val Val Tyr Leu Val Val Leu Leu Ser Val Ala Phe 
225                 230                 235                 240 


Met Cys Trp Asn Met Met Gln Val Leu Met Lys Ser Gln Lys Gly Ser 
                245                 250                 255     


Leu Ala Gly Gly Thr Arg Pro Pro Gln Leu Arg Lys Ser Glu Ser Glu 
            260                 265                 270         


Glu Ser Arg Thr Ala Arg Arg Gln Thr Ile Ile Phe Leu Arg Leu Ile 
        275                 280                 285             


Val Val Thr Leu Ala Val Cys Trp Met Pro Asn Gln Ile Arg Arg Ile 
    290                 295                 300                 


Met Ala Ala Ala Lys Pro Lys His Asp Trp Thr Arg Ser Tyr Phe Arg 
305                 310                 315                 320 


Ala Tyr Met Ile Leu Leu Pro Phe Ser Glu Thr Phe Phe Tyr Leu Ser 
                325                 330                 335     


Ser Val Ile Asn Pro Leu Leu Tyr Thr Val Ser Ser Gln Gln Phe Arg 
            340                 345                 350         


Arg Val Phe Val Gln Val Leu Cys Cys Arg Leu Ser Leu Gln His Ala 
        355                 360                 365             


Asn His Glu Lys Arg Leu Arg Val His Ala His Ser Thr Thr Asp Ser 
    370                 375                 380                 


Ala Arg Phe Val Gln Arg Pro Leu Leu Phe Ala Ser Arg Arg Gln Ser 
385                 390                 395                 400 


Ser Ala Arg Arg Thr Glu Lys Ile Phe Leu Ser Thr Phe Gln Ser Glu 
                405                 410                 415     


Ala Glu Pro Gln Ser Lys Ser Gln Ser Leu Ser Leu Glu Ser Leu Glu 
            420                 425                 430         


Pro Asn Ser Gly Ala Lys Pro Ala Asn Ser Ala Ala Glu Asn Gly Phe 
        435                 440                 445             


Gln Glu His Glu Val 
    450             


<210>  21
<211>  2627
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (84)..(536)

<400>  21
aggctaaggt cagacactga cacttgcagt tgtctttggt agtttttttg cactaacttc       60

aggaaccagc tcatgatctc agg atg tat gga aaa ata atc ttt gta tta cta      113
                          Met Tyr Gly Lys Ile Ile Phe Val Leu Leu         
                          1               5                   10          

ttg tca gaa att gtg agc ata tca gca tta agt acc act gag gtg gca        161
Leu Ser Glu Ile Val Ser Ile Ser Ala Leu Ser Thr Thr Glu Val Ala           
                15                  20                  25                

atg cac act tca act tct tct tca gtc aca aag agt tac atc tca tca        209
Met His Thr Ser Thr Ser Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser           
            30                  35                  40                    

cag aca aat gat acg cac aaa cgg gac aca tat gca gcc act cct aga        257
Gln Thr Asn Asp Thr His Lys Arg Asp Thr Tyr Ala Ala Thr Pro Arg           
        45                  50                  55                        

gct cat gaa gtt tca gaa att tct gtt aga act gtt tac cct cca gaa        305
Ala His Glu Val Ser Glu Ile Ser Val Arg Thr Val Tyr Pro Pro Glu           
    60                  65                  70                            

gag gaa acc gga gaa agg gta caa ctt gcc cat cat ttc tct gaa cca        353
Glu Glu Thr Gly Glu Arg Val Gln Leu Ala His His Phe Ser Glu Pro           
75                  80                  85                  90            

gag ata aca ctc att att ttt ggg gtg atg gct ggt gtt att gga acg        401
Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly Val Ile Gly Thr           
                95                  100                 105               

atc ctc tta att tct tac ggt att cgc cga ctg ata aag aaa agc cca        449
Ile Leu Leu Ile Ser Tyr Gly Ile Arg Arg Leu Ile Lys Lys Ser Pro           
            110                 115                 120                   

tct gat gta aaa cct ctc ccc tca cct gac aca gac gtg cct tta agt        497
Ser Asp Val Lys Pro Leu Pro Ser Pro Asp Thr Asp Val Pro Leu Ser           
        125                 130                 135                       

tct gtt gaa ata gaa aat cca gag aca agt gat caa tga gaatctgttc         546
Ser Val Glu Ile Glu Asn Pro Glu Thr Ser Asp Gln                           
    140                 145                 150                           

accaaaccaa atgtggaaag aacacaaaga agacataaga cttcagtcaa gtgaaaaatt      606

aacatgtgga ctggacactc caataaatta tatacctgcc taagttgtac aatttcagaa      666

tgcaattttc attataatga gttccagtga ctcaatgatg gggaaaaaaa tctctgctca      726

ttaatatttc aagataaaga acaaatgttt ccttgaatgc ttgcttttgt gtgttagcat      786

aatttttaga attgtttgag aattctgatc caaaacttta gttgaattca tctacgtttg      846

tttaatatta acttaaccta ttctattgta ttataatgat gattctgtca aatgaaaggc      906

ttgaaatacc tagatgaagt ttagattttc ttcctattgt aaacttttga gtctggtttc      966

attgttttaa ataaattaag gggacactaa agtcctatca ttcatttcct tcattgctga     1026

acaggcaaga tataatatta catgaatgat tactatattt tgttcacact aataaagctt     1086

atgctcagaa atgccataca cacacacaca cacacacaca aacacacaca tttatcattt     1146

aatgcataaa tcaacacaaa aggttttccc attaatatga aatattacat atatataagt     1206

gccatattta aaataatttg tctaacagta gaactgtgtc ggagcactca ctgaagcttg     1266

cattccactg aaagagttat ttgtgtaagt agagtatccg gagaaggaaa agaacttacg     1326

acctttcttt ataacagaaa ctcaactcta aattcaacaa gatgtgcaaa ccggacatgc     1386

aggtgaatat tttaataggt tactataagg ttctcaatta aattctttaa tctgtccagt     1446

cccagtttct cttattaata aaactttgga aattgcttta aaccatttaa aggaaatttc     1506

tagatataga aactaaggac tgtgactata cagctgtcac tcatttgtag taaaacttaa     1566

aaagcaaaaa caaaaaacaa aaaagacctt cctgtgatac tttatttccg aactaataaa     1626

aatctatatg actttttatt attgtgtgat aaccaagtaa atgttttcta ttttgcatat     1686

tttcaggcat ggtaacagaa atttaccttt taataaatta aaaaatctaa attttaacct     1746

acttgtatgt tcggagagtg tttttgtact atattgacta cttaaaatag agaatgagac     1806

taagaaggga acatttctgt tgatacatgt tttttaaaag taattttaag agcattatta     1866

ggttaattaa tccaattaat gacccaaatg ccaaggtaat tttaaattta catttttaat     1926

aaaagcaaca tgttgaaaca agagagggtg agattaacct ttttgctaaa gtaatttaca     1986

agtcaaagac aggaagagat cagagtgaat gtgccttctt aaccagagct acagaattta     2046

gtgaataatt aaagtacaaa ctgctttgac ctccttgaac ttttccaagc aatttctctg     2106

tacttctata tatgaatgtc ttagccaatt ttctgctact ataacagaat acgacagact     2166

gggtaattta aaaagaaaag aaatttattt tcttcctagt tctggaggct gggaaggcga     2226

agggcatggc actgacatct gccttgtaac tgatgagaac cttcttactg catgataaca     2286

aagcagcaag gcaagcaaaa gcgtaagatg aagagagagg aaatgaagcc aaacacatcc     2346

tttcatcaga agcccattcc ctctataagg cgttattaca tttatgagaa tggagtcctc     2406

atgacctaat cgtgacctta aaggcccctc ccaacactgt tacaatggca attaaatttc     2466

aacaaaggtt ccagaggtga cattcgaatc agcaatgaaa ttttcatagt taaatttggt     2526

attcgtgggg gaagaaatga ccatttccct tgtattttta taattaaatc agcaaaatat     2586

tgtaataaag aaatctttcc tgtgaagata ccatgacccc a                         2627


<210>  22
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Glu Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Leu Ser Thr Thr Glu Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His 
        35                  40                  45              


Lys Arg Asp Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu 
    50                  55                  60                  


Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg 
65                  70                  75                  80  


Val Gln Leu Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile 
                85                  90                  95      


Phe Gly Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr 
            100                 105                 110         


Gly Ile Arg Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu 
        115                 120                 125             


Pro Ser Pro Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn 
    130                 135                 140                 


Pro Glu Thr Ser Asp Gln 
145                 150 


<210>  23
<211>  628
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (51)..(494)

<400>  23
acatttgctt ctgacacaac tgtgttcact agcaacctca aacagacacc atg gtg          56
                                                       Met Val            
                                                       1                  

cat ctg act cct gag gag aag tct gcc gtt act gcc ctg tgg ggc aag        104
His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp Gly Lys           
        5                   10                  15                        

gtg aac gtg gat gaa gtt ggt ggt gag gcc ctg ggc agg ctg ctg gtg        152
Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu Leu Val           
    20                  25                  30                            

gtc tac cct tgg acc cag agg ttc ttt gag tcc ttt ggg gat ctg tcc        200
Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp Leu Ser           
35                  40                  45                  50            

act cct gat gct gtt atg ggc aac cct aag gtg aag gct cat ggc aag        248
Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His Gly Lys           
                55                  60                  65                

aaa gtg ctc ggt gcc ttt agt gat ggc ctg gct cac ctg gac aac ctc        296
Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn Leu           
            70                  75                  80                    

aag ggc acc ttt gcc aca ctg agt gag ctg cac tgt gac aag ctg cac        344
Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys Leu His           
        85                  90                  95                        

gtg gat cct gag aac ttc agg ctc ctg ggc aac gtg ctg gtc tgt gtg        392
Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val Cys Val           
    100                 105                 110                           

ctg gcc cat cac ttt ggc aaa gaa ttc acc cca cca gtg cag gct gcc        440
Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln Ala Ala           
115                 120                 125                 130           

tat cag aaa gtg gtg gct ggt gtg gct aat gcc ctg gcc cac aag tat        488
Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His Lys Tyr           
                135                 140                 145               

cac taa gctcgctttc ttgctgtcca atttctatta aaggttcctt tgttccctaa         544
His                                                                       
                                                                          

gtccaactac taaactgggg gatattatga agggccttga gcatctggat tctgcctaat      604

aaaaaacatt tattttcatt gcaa                                             628


<210>  24
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  25
<211>  3991
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (53)..(829)

<400>  25
ccttcttttc ctgactgcag ctcttttcat tttgccatcc ttttccagct cc atg atg       58
                                                          Met Met         
                                                          1               

gtt ctg cag gtt tct gcg gcc ccc cgg aca gtg gct ctg acg gcg tta        106
Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr Ala Leu           
        5                   10                  15                        

ctg atg gtg ctg ctc aca tct gtg gtc cag ggc agg gcc act cca gag        154
Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr Pro Glu           
    20                  25                  30                            

aat tac ctt ttc cag gga cgg cag gaa tgc tac gcg ttt aat ggg aca        202
Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn Gly Thr           
35                  40                  45                  50            

cag cgc ttc ctg gag aga tac atc tac aac cgg gag gag ttc gcg cgc        250
Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe Ala Arg           
                55                  60                  65                

ttc gac agc gac gtg ggg gag ttc cgg gcg gtg acg gag ctg ggg cgg        298
Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu Gly Arg           
            70                  75                  80                    

cct gct gcg gag tac tgg aac agc cag aag gac atc ctg gag gag aag        346
Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu Glu Lys           
        85                  90                  95                        

cgg gca gtg ccg gac agg atg tgc aga cac aac tac gag ctg ggc ggg        394
Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu Gly Gly           
    100                 105                 110                           

ccc atg acc ctg cag cgc cga gtc cag cct agg gtg aat gtt tcc ccc        442
Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg Val Asn Val Ser Pro           
115                 120                 125                 130           

tcc aag aag ggg ccc ttg cag cac cac aac ctg ctt gtc tgc cac gtg        490
Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys His Val           
                135                 140                 145               

acg gat ttc tac cca ggc agc att caa gtc cga tgg ttc ctg aat gga        538
Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu Asn Gly           
            150                 155                 160                   

cag gag gaa aca gct ggg gtc gtg tcc acc aac ctg atc cgt aat gga        586
Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg Asn Gly           
        165                 170                 175                       

gac tgg acc ttc cag atc ctg gtg atg ctg gaa atg acc ccc cag cag        634
Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro Gln Gln           
    180                 185                 190                           

gga gat gtc tac acc tgc caa gtg gag cac acc agc ctg gat agt cct        682
Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr Ser Leu Asp Ser Pro           
195                 200                 205                 210           

gtc acc gtg gag tgg aag gca cag tct gat tct gcc cgg agt aag aca        730
Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser Lys Thr           
                215                 220                 225               

ttg acg gga gct ggg ggc ttc gtg ctg ggg ctc atc atc tgt gga gtg        778
Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys Gly Val           
            230                 235                 240                   

ggc atc ttc atg cac agg agg agc aag aaa gtt caa cga gga tct gca        826
Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly Ser Ala           
        245                 250                 255                       

taa acagggttcc tgagctcact gaaaagacta ttgtgcctta ggaaaagcat             879

ttgctgtgtt tcgttagcat ctggctccag gacagacctt caacttccaa attggatact      939

gctgccaaga agttgctctg aagtcagttt ctatcattct gctctttgat tcaaagcact      999

gtttctctca ctgggcctcc aaccatgttc ccttcttctt agcaccacaa ataatcaaaa     1059

cccaacatga ctgtttgttt tcctttaaaa atatgcacca aatcatctct catcactttt     1119

ctctgagggt tttagtagac agtaggagtt aataaagaag ttcattttgg tttaaacata     1179

ggaaagaaga gaaccatgaa aatggggata tgttaactat tgtataatgg ggcctgttac     1239

acatgacact cttctgaatt gactgtattt cagtgagctg cccccaaatc aagtttagtg     1299

ccctcatcca tttatgtctc agaccactat tcttaactat tcaatggtga gcagactgca     1359

aatctgcctg ataggaccca tattcccaca gcactaattc aacatatacc ttactgagag     1419

catgttttat cattaccatt aagaagttaa atgaacatca gaatttaaaa tcataaatat     1479

aatctaatac actttaacca ttttctttgt gtgccatcac aaatactcct taaccaaata     1539

cggcttggac ttttgaatgc atccaataga cgtcatttgt cgtctaagtc tgcattcatc     1599

caccagccta ggcctcctgt cttaattttc atacagacag aaatgactcc ccactgggga     1659

aagagcaaag caatacatgt agcactcttt ttcaaacact ggtctttttt tttttcttaa     1719

caatccaaca ttgttatgtg ttttgcgtct catattgaca ccttttggtc aaggtagagg     1779

acatgtttgt tgtaagcttt ctttttcgtg tagaggatgg attcttcact cctgatacac     1839

acaatcagtg cacagcagct ctcttataca tccagttgat gccttcagtc tccctggctt     1899

cttacaagca tcttctgggc cttgtgtgtc cctgggcacc tgtccctggt caattcccga     1959

aagctactgt gctcctcttg cccatctccc cttgcaaata atatcttcca tcgggggacc     2019

ggcttcctcc aatttcagga gaggtggggc tgaaggcaca gacttgggcg tcactggcac     2079

agatataagt aaatacagct ggagtctgca gagaggctgg actgagtcag ggagtcagga     2139

aagagaagcc acacacaagg acaaccaatc atgtttctca taatcttctt aacctaggga     2199

ataggacaca atcatttttt ctttttaaaa catctttatc cctgatcagc ctcatttcct     2259

caaaaactat aaaggaaaat gctgctgact tgtttttgcg tagtaatttc agctgtcaca     2319

taataagcta aggaagacag tatatagtaa ataaggaccc tttatctgtc ttattttccc     2379

ttttggcttc acaggaaact tgtgagaaac ctatgcagca taaaattaat atgatttcaa     2439

tccagggatt caacgatgga aggaggtcat gagaatagca gaaagtcttc aaatcgagat     2499

cattatgaaa tcctcagacc cagagcacat aaatcctacc ctcagagtca ctgagcagtt     2559

aacattacaa attacaaacc atatccagtc agagtcattc tctttcctgc ttgtctcctg     2619

tactcatgtt acaggttagg gcagtacccc gagtggagtg aacaatctct ggactaacac     2679

ttgtcaggat cagaagctga ggtatctgca cccacattac aggaacagga tatgtgctcc     2739

tagggaactg agggtgtcag gagatgagga atgtccctgg agtcacagaa agaaggtatc     2799

agatgtgtct cactctgaca tatgcaggtg tttatgaaac tctgggattt ctaaggaagg     2859

atgcagtgca gagacaggtc ccagaggaga caagagctga gagaccatcc aaactgggac     2919

caccttgtca ctagacttca aattttcaat attgatagag tgttttctaa gagtcaggcc     2979

ctttgctgag tgctatgtgc agcaggatca aaggcagcca ggaggtagag gagtcttgag     3039

gtacatcagt cattggagtt gaagagcaga gattcaaagg aaagttggaa ctggagcttt     3099

aaaggagatg tgaagtgggt gactcaacct ctgactcaga aaaattgata cctgcagaag     3159

aaaaaacccg gcgggcttag gactcccagc tgagtgttgt atcctccatc cctttccacc     3219

tggtcccttc attttctacc cctcacagtt ccctaacgag aaggtggtcc acccaacaga     3279

caacactgcc tcagatggtt atcaaggggt accctaagaa gaaatcatct caccctctct     3339

ttgtccccat ttgtcaagta gcagtgaggc cgagccaggg gatggtgaaa gtggaaggag     3399

gtgggagttg ggcatcgggt gtgaagatgc tcttgaaagg ggttttaata accacttgct     3459

accaggccag tgaacactta ccatagttga tgccttttga gcatgttgca ttgtaaactg     3519

tccctgaaat tactgtgcac ttggcttatg ggatgaaaca tcctcctagt tcttttgtct     3579

ctcagcttct ctgaagtctc attgagcacc ttctcttcaa tttcttttac acagtaagaa     3639

taggatcagc tgtgctaaac taacaaatac ccagatatcc aggtttggct catgttacac     3699

gtccaaagta agtcatgcag gaagctctgc tcatcatcgt actcaggaag tcaggctgac     3759

agtctttctc ctgcacatct gctcccagaa cctccccagc agaatgaagg gaacctaaga     3819

atttattcac tggcttttaa tgatccctcc tagaaagaac acacttctcg catttcattt     3879

tccaatgtaa atcatatggc tgcaactaac ttcaaataag tgggaatact tgaaggtgga     3939

aaacatttaa gaagtacaca ctaaataaat aataaaatac ttctacaaga ga             3991


<210>  26
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Lys Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  27
<211>  899
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (322)..(741)

<400>  27
agatgcccct ctgggagaga tccccagggg tgacagccat ggaccctgga agggcctggg       60

ctagggacag ggaccagagc cagtccaggg agaggacaga gccaatggac tggggtgtac      120

tgtaacagcc ctgctggcga gagggaccag ggcaccgtcc tccagggagc ccatgctgca      180

agtcgggcca gaggtgcccc tgaacctgaa ggccaatgag acccaagaca ggccaagtgg      240

gttgtgagac ccctgaggag ctgggccctg gtcccaggca gcgctggccc ctgctgctgc      300

tgggtctggc catggtcgcc c atg gcc tgc tgc gcc caa tgg ttg cac cgc        351
                        Met Ala Cys Cys Ala Gln Trp Leu His Arg           
                        1               5                   10            

aaa gcg ggg acc cag acc ctg gag cct cag ttg gaa gca gcc gat cca        399
Lys Ala Gly Thr Gln Thr Leu Glu Pro Gln Leu Glu Ala Ala Asp Pro           
                15                  20                  25                

gcc tgc gga gcc tgt ggg gca ggt cag ccc aag gct gcc ccc tcg gtc        447
Ala Cys Gly Ala Cys Gly Ala Gly Gln Pro Lys Ala Ala Pro Ser Val           
            30                  35                  40                    

act ctg ttc ccg ccc tcc tct gag gag ctt caa gcc aac aag gcc aca        495
Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr           
        45                  50                  55                        

ctg gtg tgt ctc ata agt gac ttc tac ccg gga gcc gtg aca gtg gcc        543
Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala           
    60                  65                  70                            

tgg aag gca gat agc agc ccc gtc aag gcg gga gtg gag acc acc aca        591
Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr           
75                  80                  85                  90            

ccc tcc aaa caa agc aac aac aag tac gcg gcc agc agc tac ctg agc        639
Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser           
                95                  100                 105               

ctg acg cct gag cag tgg aag tcc cac aga agc tac agc tgc cag gtc        687
Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val           
            110                 115                 120                   

acg cat gaa ggg agc acc gtg gag aag aca gtg gcc cct aca gaa tgt        735
Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys           
        125                 130                 135                       

tca tag gttctcaacc ctcaccccca ccacgggaga ctagagctgc aggatcccag         791
Ser                                                                       
                                                                          

gggaggggtc tctcctccca ccccaaggca tcaagccctt ctccctgcac tcaataaacc      851

ctcaataaat attctcattg tcaatcaaaa aaaaaaaaaa aaaaaaaa                   899


<210>  28
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Cys Cys Ala Gln Trp Leu His Arg Lys Ala Gly Thr Gln Thr 
1               5                   10                  15      


Leu Glu Pro Gln Leu Glu Ala Ala Asp Pro Ala Cys Gly Ala Cys Gly 
            20                  25                  30          


Ala Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser 
        35                  40                  45              


Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser 
    50                  55                  60                  


Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser 
65                  70                  75                  80  


Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn 
                85                  90                  95      


Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp 
            100                 105                 110         


Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr 
        115                 120                 125             


Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    130                 135                 


<210>  29
<211>  1192
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (127)..(1068)

<400>  29
attccacatc aggagcgttt ttggagaaag ctgcactctg ttgagctcca gggcgcagtg       60

gagggaggga gtgaaggagc tctctgtacc caaggaaagt gcagctgaga ctcagacaag      120

attaca atg aac caa ctc agc ttc ctg ctg ttt ctc ata gcg acc acc         168
       Met Asn Gln Leu Ser Phe Leu Leu Phe Leu Ile Ala Thr Thr            
       1               5                   10                             

aga gga tgg agt aca gat gag gct aat act tac ttc aag gaa tgg acc        216
Arg Gly Trp Ser Thr Asp Glu Ala Asn Thr Tyr Phe Lys Glu Trp Thr           
15                  20                  25                  30            

tgt tct tcg tct cca tct ctg ccc aga agc tgc aag gaa atc aaa gac        264
Cys Ser Ser Ser Pro Ser Leu Pro Arg Ser Cys Lys Glu Ile Lys Asp           
                35                  40                  45                

gaa tgt cct agt gca ttt gat ggc ctg tat ttt ctc cgc act gag aat        312
Glu Cys Pro Ser Ala Phe Asp Gly Leu Tyr Phe Leu Arg Thr Glu Asn           
            50                  55                  60                    

ggt gtt atc tac cag acc ttc tgt gac atg acc tct ggg ggt ggc ggc        360
Gly Val Ile Tyr Gln Thr Phe Cys Asp Met Thr Ser Gly Gly Gly Gly           
        65                  70                  75                        

tgg acc ctg gtg gcc agc gtg cac gag aat gac atg cgt ggg aag tgc        408
Trp Thr Leu Val Ala Ser Val His Glu Asn Asp Met Arg Gly Lys Cys           
    80                  85                  90                            

acg gtg ggc gat cgc tgg tcc agt cag cag ggc agc aaa gca gtc tac        456
Thr Val Gly Asp Arg Trp Ser Ser Gln Gln Gly Ser Lys Ala Val Tyr           
95                  100                 105                 110           

cca gag ggg gac ggc aac tgg gcc aac tac aac acc ttt gga tct gca        504
Pro Glu Gly Asp Gly Asn Trp Ala Asn Tyr Asn Thr Phe Gly Ser Ala           
                115                 120                 125               

gag gcg gcc acg agc gat gac tac aag aac cct ggc tac tac gac atc        552
Glu Ala Ala Thr Ser Asp Asp Tyr Lys Asn Pro Gly Tyr Tyr Asp Ile           
            130                 135                 140                   

cag gcc aag gac ctg ggc atc tgg cac gtg ccc aat aag tcc ccc atg        600
Gln Ala Lys Asp Leu Gly Ile Trp His Val Pro Asn Lys Ser Pro Met           
        145                 150                 155                       

cag cac tgg aga aac agc tcc ctg ctg agg tac cgc acg gac act ggc        648
Gln His Trp Arg Asn Ser Ser Leu Leu Arg Tyr Arg Thr Asp Thr Gly           
    160                 165                 170                           

ttc ctc cag aca ctg gga cat aat ctg ttt ggc atc tac cag aaa tat        696
Phe Leu Gln Thr Leu Gly His Asn Leu Phe Gly Ile Tyr Gln Lys Tyr           
175                 180                 185                 190           

cca gtg aaa tat gga gaa gga aag tgt tgg act gac aac ggc ccg gtg        744
Pro Val Lys Tyr Gly Glu Gly Lys Cys Trp Thr Asp Asn Gly Pro Val           
                195                 200                 205               

atc cct gtg gtc tat gat ttt ggc gac gcc cag aaa aca gca tct tat        792
Ile Pro Val Val Tyr Asp Phe Gly Asp Ala Gln Lys Thr Ala Ser Tyr           
            210                 215                 220                   

tac tca ccc tat ggc cag cgg gaa ttc act gcg gga ttt gtt cag ttc        840
Tyr Ser Pro Tyr Gly Gln Arg Glu Phe Thr Ala Gly Phe Val Gln Phe           
        225                 230                 235                       

agg gta ttt aat aac gag aga gca gcc aac gcc ttg tgt gct gga atg        888
Arg Val Phe Asn Asn Glu Arg Ala Ala Asn Ala Leu Cys Ala Gly Met           
    240                 245                 250                           

agg gtc acc gga tgt aac act gag cac cac tgc att ggt gga gga gga        936
Arg Val Thr Gly Cys Asn Thr Glu His His Cys Ile Gly Gly Gly Gly           
255                 260                 265                 270           

tac ttt cca gag gcc agt ccc cag cag tgt gga gat ttt tct ggt ttt        984
Tyr Phe Pro Glu Ala Ser Pro Gln Gln Cys Gly Asp Phe Ser Gly Phe           
                275                 280                 285               

gat tgg agt gga tat gga act cat gtt ggt tac agc agc agc cgt gag       1032
Asp Trp Ser Gly Tyr Gly Thr His Val Gly Tyr Ser Ser Ser Arg Glu           
            290                 295                 300                   

ata act gag gca gct gtg ctt cta ttc tat cgt tga gagttttgtg            1078
Ile Thr Glu Ala Ala Val Leu Leu Phe Tyr Arg                               
        305                 310                                           

ggagggaacc cagacctctc ctcccaacca tgagatccca aggatggaga acaacttacc     1138

cagtagctag aatgttaatg gcagaagaga aaacaataaa tcatattgac tcaa           1192


<210>  30
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Asn Gln Leu Ser Phe Leu Leu Phe Leu Ile Ala Thr Thr Arg Gly 
1               5                   10                  15      


Trp Ser Thr Asp Glu Ala Asn Thr Tyr Phe Lys Glu Trp Thr Cys Ser 
            20                  25                  30          


Ser Ser Pro Ser Leu Pro Arg Ser Cys Lys Glu Ile Lys Asp Glu Cys 
        35                  40                  45              


Pro Ser Ala Phe Asp Gly Leu Tyr Phe Leu Arg Thr Glu Asn Gly Val 
    50                  55                  60                  


Ile Tyr Gln Thr Phe Cys Asp Met Thr Ser Gly Gly Gly Gly Trp Thr 
65                  70                  75                  80  


Leu Val Ala Ser Val His Glu Asn Asp Met Arg Gly Lys Cys Thr Val 
                85                  90                  95      


Gly Asp Arg Trp Ser Ser Gln Gln Gly Ser Lys Ala Val Tyr Pro Glu 
            100                 105                 110         


Gly Asp Gly Asn Trp Ala Asn Tyr Asn Thr Phe Gly Ser Ala Glu Ala 
        115                 120                 125             


Ala Thr Ser Asp Asp Tyr Lys Asn Pro Gly Tyr Tyr Asp Ile Gln Ala 
    130                 135                 140                 


Lys Asp Leu Gly Ile Trp His Val Pro Asn Lys Ser Pro Met Gln His 
145                 150                 155                 160 


Trp Arg Asn Ser Ser Leu Leu Arg Tyr Arg Thr Asp Thr Gly Phe Leu 
                165                 170                 175     


Gln Thr Leu Gly His Asn Leu Phe Gly Ile Tyr Gln Lys Tyr Pro Val 
            180                 185                 190         


Lys Tyr Gly Glu Gly Lys Cys Trp Thr Asp Asn Gly Pro Val Ile Pro 
        195                 200                 205             


Val Val Tyr Asp Phe Gly Asp Ala Gln Lys Thr Ala Ser Tyr Tyr Ser 
    210                 215                 220                 


Pro Tyr Gly Gln Arg Glu Phe Thr Ala Gly Phe Val Gln Phe Arg Val 
225                 230                 235                 240 


Phe Asn Asn Glu Arg Ala Ala Asn Ala Leu Cys Ala Gly Met Arg Val 
                245                 250                 255     


Thr Gly Cys Asn Thr Glu His His Cys Ile Gly Gly Gly Gly Tyr Phe 
            260                 265                 270         


Pro Glu Ala Ser Pro Gln Gln Cys Gly Asp Phe Ser Gly Phe Asp Trp 
        275                 280                 285             


Ser Gly Tyr Gly Thr His Val Gly Tyr Ser Ser Ser Arg Glu Ile Thr 
    290                 295                 300                 


Glu Ala Ala Val Leu Leu Phe Tyr Arg 
305                 310             


<210>  31
<211>  2901
<212>  DNA
<213>  Homo sapiens

<400>  31
gtttagatta ggttggaagt cacctgggct gagctgatgg ctgattccgt cagcaaaaag       60

aactgtggaa catactggca cttgggccgg tgtgaagcca cccccctgcc atgaaaaatg      120

gctcttccct gccacagccg gcccagcggg agccaggtca gggcctggag acacagcgcc      180

ccccaccgga gccactgccc ggcccagcag cacctgcgga gaatcccacc agctcccacg      240

cctcccgccg cgccaccgcc ccggctttct gcaaatccac cttatggaag ccggataagc      300

acctcctcct ctgatgcgtc acagtcacag gtcctggtga ggagggagcc acgccaagca      360

cagcggctgg aacaggggca agtgggtgcc caccccgaag tgcaggcaat gaacttgtgc      420

tgtagcccat ggtgagctgt ggggctgttt gtgactgcag cgtagccaag cccatcccgc      480

ctgatgcggc ctcttcatcc agagtggggg tgacgtgcca gcccccacct caccggaatg      540

ctgggaggag cgtctccacg gaaggagctc actttgtcag ctgtaatgtg ctgtgactat      600

cgtaaagttc cttccgggtg cagagtgata catgaaccct ggggactcac tccaacttgg      660

tattgatttt ctccacggag gacccagcag tcacggcccg tgtctgcaca gccccttgga      720

tcctgcggag gaattcagcc ggcccctccc cctgtgccga aaaccacgga ggcaaagcca      780

ggccagggta cagtgagaac acgggagagg actgagagac cgctggctgc cgagggagga      840

agagcaggat tcgcaccccc gtcatcgctg ggcccacacg ccgccgacag cttccgcgtg      900

tggccatctg tctttcagaa accctctggc agagggaccc agcagatgac acgggggccg      960

ttcacactct gaaacctgcc tggagtcaaa acactgctgg cgagcctcca ccgcaaaccc     1020

aatccagatg gtcttccctg gtggccctcg gggtggcggg caccctgccc actccctgcc     1080

agcccctgcc cgctggactc caggcccggc cgagcccccg accggtctcc tgacccagca     1140

tgctgctctc ccctgggccc ggctttctcg cccgctggga ctcccaggcc cctccagccc     1200

agccccgaga gcaggagccc caagggaggc ttggcggctg tggaggcgag tgggccacgt     1260

gtagctggga ggccggcagg accaggagcc cctcacagcg cagcacccac agcatcacga     1320

gccacttcca ctcctgggtg gcctgggggc ccccaccctg ctctgagctg ccccttgttg     1380

tgacctgggg tcccccgtgg tgggcccgcc ccttgagcct gggatccagc ctcagcgagg     1440

ctccagaagt gtcgtctccg ccggccaggc gtcagcgcct ccacccagga tcacacactc     1500

ctatctctgc acttctgccc tccatcctgc tccacgccgc ctctgcttgt tattccagca     1560

cattccaggg tgatgcctgc tgaagccacg cagccagtgc ctccacccta ccccccatct     1620

gacccaccgg ccccttccgc acgctggaag cctgcccggc ctgaagtgtc ctcacctgtc     1680

gccctatcct cccctccact ccagcccacc ggtgactcag ccctcacagc tctctcctcc     1740

ccgagggagc cggtgacttg gctctgatgg tgccgggacc cagccccggc atgttcagaa     1800

tccttgtcct ttaacctgcg tccacatgta gtcgcctcca cctccctgcc tgaacctcca     1860

ggccctgcag agcaaacact gctgcctgca ggagacccct ggggccttct ccgtcccctc     1920

atcctcctaa ggagcctccc ctgccaccgt gccagaatgt gccggaggaa cagaggcccg     1980

agcctcccgt ggccccagcg aggcttcctc tggggaagac agtgagccca acgccctggc     2040

tctcgagggg tggacggagt ccagctggca tcgaccgggt gcccctcttc accggtgtcc     2100

acagtccttg agagcaaagg gttcccagag gcgacctccc tcctgcacag gcatttgtca     2160

tccttaccct ctaggacagc tttgccatgt gcagtgaacc cctggacagt gttgcgtgcc     2220

actttgccgg atttggactg tatacagacc gaagcatgtg gcatgaagcc ttctgctgtc     2280

agcaagttcc ttgtccctcg acagtatgtg cccaggctgc ccttcaaggt ggcagtgatg     2340

gcagttgtct cttgcacgct gcgtacagtt ctgtcactga ctcttacaca cagccctgga     2400

gacgggagag tgccgggagc attctatgca agtgtcctgg cctttgcggg cgtctccaca     2460

gcacaaacac gagtcaggga ccacccctct tctgcttcca tgattccacc aactgggtgg     2520

ggcagagcag tgccagggcc ggaggcacgc cccaggtgag ggcaggtggc catgccagtg     2580

agtgcactgc gttctcagtt aattcatccg aaatatttct aagtttcttg attattgcag     2640

ttgcatcccc aagataatgc cgccctcacc aagtagaagg cacatgtgct ctgatggccc     2700

ctcccacact ggggtcaggg cacagcaact tagcgaggcg acgtgggggc tcagaggacc     2760

tcggaccagg ctcggcacat ggggcttctc cagccagcca gggggaagca ccctgcagac     2820

tgctaacttt tgcaaaatag agtaaaaaag atcagctaga aaaataaaac aaaaaaggaa     2880

agatatacaa aatacaaggc c                                               2901


<210>  32
<211>  2540
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (174)..(1607)

<400>  32
ctcttttcct ccctcccgcc ggccggggtg cgcgggcggc ggggcggccc gcgggccatg       60

cgttcggcgc ggcccagccc ggccggccgg gggcggcgcc ccgagcccgg gccccgcgcg      120

gcccgcgccc ccggcccccg ctgagccccg ggggccccgc tgcggccgag gcc atg         176
                                                           Met            
                                                           1              

ttc ccg gtg ttt cct tgc acg ctg ctg gcc ccc ccc ttc ccc gtg ctg        224
Phe Pro Val Phe Pro Cys Thr Leu Leu Ala Pro Pro Phe Pro Val Leu           
            5                   10                  15                    

ggc ctg gac tcc cgg ggg gtg ggc ggc ctc atg aac tcc ttc ccg cca        272
Gly Leu Asp Ser Arg Gly Val Gly Gly Leu Met Asn Ser Phe Pro Pro           
        20                  25                  30                        

cct cag ggt cac gcc cag aac ccc ctg cag gtc ggg gct gag ctc cag        320
Pro Gln Gly His Ala Gln Asn Pro Leu Gln Val Gly Ala Glu Leu Gln           
    35                  40                  45                            

tcc cgc ttc ttt gcc tcc cag ggc tgc gcc cag agt cca ttc cag gcc        368
Ser Arg Phe Phe Ala Ser Gln Gly Cys Ala Gln Ser Pro Phe Gln Ala           
50                  55                  60                  65            

gcg ccg gcg ccc ccg ccc acg ccc cag gcc ccg gcg gcc gag ccc ctc        416
Ala Pro Ala Pro Pro Pro Thr Pro Gln Ala Pro Ala Ala Glu Pro Leu           
                70                  75                  80                

cag gtg gac ttg ctc ccg gtg ctc gcc gcc gcc cag gag tcc gcc gcg        464
Gln Val Asp Leu Leu Pro Val Leu Ala Ala Ala Gln Glu Ser Ala Ala           
            85                  90                  95                    

gct gct gcg gcc gct gcc gcc gct gct gcc gcc gtc gct gcc gcg ccc        512
Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Ala Ala Pro           
        100                 105                 110                       

ccg gcc cct gcc gcc gcc tct acg gtg gac aca gcg gcc ctg aag cag        560
Pro Ala Pro Ala Ala Ala Ser Thr Val Asp Thr Ala Ala Leu Lys Gln           
    115                 120                 125                           

cct ccg gcg ccc cct ccg cca ccc ccg cca gtg tcg gcg ccc gcg gcc        608
Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Val Ser Ala Pro Ala Ala           
130                 135                 140                 145           

gag gcc gcg ccc ccc gcc tcc gcc gcc act atc gcc gcg gcg gcg gcc        656
Glu Ala Ala Pro Pro Ala Ser Ala Ala Thr Ile Ala Ala Ala Ala Ala           
                150                 155                 160               

acc gcc gtc gta gcc cca acc tcg acg gtc gcc gtg gcc ccg gtc gcg        704
Thr Ala Val Val Ala Pro Thr Ser Thr Val Ala Val Ala Pro Val Ala           
            165                 170                 175                   

tct gcc ttg gag aag aag aca aag agc aag ggg ccc tac atc tgc gct        752
Ser Ala Leu Glu Lys Lys Thr Lys Ser Lys Gly Pro Tyr Ile Cys Ala           
        180                 185                 190                       

ctg tgc gcc aag gag ttc aag aac ggc tac aat ctc cgg agg cac gaa        800
Leu Cys Ala Lys Glu Phe Lys Asn Gly Tyr Asn Leu Arg Arg His Glu           
    195                 200                 205                           

gcc atc cac acg gga gcc aag gcc ggc cgg gtc ccc tcg ggt gct atg        848
Ala Ile His Thr Gly Ala Lys Ala Gly Arg Val Pro Ser Gly Ala Met           
210                 215                 220                 225           

aag atg ccg acc atg gtg ccc ctg agc ctc ctg agc gtg ccc cag ctg        896
Lys Met Pro Thr Met Val Pro Leu Ser Leu Leu Ser Val Pro Gln Leu           
                230                 235                 240               

agc gga gcc ggc ggg gga ggg gga gag gcg ggt gcc ggc ggc ggc gct        944
Ser Gly Ala Gly Gly Gly Gly Gly Glu Ala Gly Ala Gly Gly Gly Ala           
            245                 250                 255                   

gcc gca gtg gcc gcc ggt ggc gtg gtg acc acg acc gcc tcg ggg aag        992
Ala Ala Val Ala Ala Gly Gly Val Val Thr Thr Thr Ala Ser Gly Lys           
        260                 265                 270                       

cgc atc cgg aag aac cat gcc tgc gag atg tgt ggc aag gcc ttc cgc       1040
Arg Ile Arg Lys Asn His Ala Cys Glu Met Cys Gly Lys Ala Phe Arg           
    275                 280                 285                           

gac gtc tac cac ctg aac cga cac aag ctg tcg cac tcg gac gag aag       1088
Asp Val Tyr His Leu Asn Arg His Lys Leu Ser His Ser Asp Glu Lys           
290                 295                 300                 305           

ccc tac cag tgc ccg gtg tgc cag cag cgc ttc aag cgc aag gac cgc       1136
Pro Tyr Gln Cys Pro Val Cys Gln Gln Arg Phe Lys Arg Lys Asp Arg           
                310                 315                 320               

atg agc tac cac gtg cgc tca cat gac ggc gct gtg cac aag ccc tac       1184
Met Ser Tyr His Val Arg Ser His Asp Gly Ala Val His Lys Pro Tyr           
            325                 330                 335                   

aac tgc tcc cac tgt ggc aag agc ttc tcc cgg ccg gat cac ctc aac       1232
Asn Cys Ser His Cys Gly Lys Ser Phe Ser Arg Pro Asp His Leu Asn           
        340                 345                 350                       

agt cac gtc aga caa gtg cac tca aca gaa cgg ccc ttc aaa tgt gag       1280
Ser His Val Arg Gln Val His Ser Thr Glu Arg Pro Phe Lys Cys Glu           
    355                 360                 365                           

aaa tgt gag gca gct ttc gcc acg aag gat cgg ctg cgg gcg cac aca       1328
Lys Cys Glu Ala Ala Phe Ala Thr Lys Asp Arg Leu Arg Ala His Thr           
370                 375                 380                 385           

gta cga cac gag gag aaa gtg cca tgt cac gtg tgt ggc aag atg ctg       1376
Val Arg His Glu Glu Lys Val Pro Cys His Val Cys Gly Lys Met Leu           
                390                 395                 400               

agc tcg gct tat att tcg gac cac atg aag gtg cac agc cag ggt cct       1424
Ser Ser Ala Tyr Ile Ser Asp His Met Lys Val His Ser Gln Gly Pro           
            405                 410                 415                   

cac cat gtc tgt gag ctc tgc aac aaa ggt act ggt gag gtt tgt cca       1472
His His Val Cys Glu Leu Cys Asn Lys Gly Thr Gly Glu Val Cys Pro           
        420                 425                 430                       

atg gcg gcg gca gcg gca gcg gcg gca gcg gca gca gcg gca gca gta       1520
Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val           
    435                 440                 445                           

gca gcc cct ccc aca gct gtg ggc tcc ctc tcg ggg gcg gag ggg gtg       1568
Ala Ala Pro Pro Thr Ala Val Gly Ser Leu Ser Gly Ala Glu Gly Val           
450                 455                 460                 465           

cct gtg agc tct cag cca ctt ccc tcc caa ccc tgg tga gctccaagtt        1617
Pro Val Ser Ser Gln Pro Leu Pro Ser Gln Pro Trp                           
                470                 475                                   

ggttgcgggg gagaggggag aatggagtag agtcccttgg tacaagctcc tctcccccct     1677

cttttcccac caactcctat ttccctacca accaaggagc ctccagaagg aaaggaggaa     1737

gaaatgtttt cttaggggaa ttcgctaggt tttaacgatt tgtttctcct gctcctcttc     1797

tgtcagacct gaccccacac aaacctgtcc cctcggttgt gttgaagtcc cctggacagt     1857

gggcaggggt ggcagaggac acgagcagcc actgcccgta ccccctctcc tctctgtaag     1917

cccatgccct gtcttcccag ggacttgtga gcctcttccc tcgacggtcc tcttctctcc     1977

ttccagtcct ctccccctgc tgtctgcagc ccctccccgg ggagttggtg ctttcttttc     2037

cttttttttt tttttccagg gggagggagg agaggaagga gggggatcag agctgtccca     2097

aagagggaaa gcggtgaggt ttgaggaggg gcagaagcag ggccggcaaa ggttgtacct     2157

tcataaggtg gtatgggggg ttggggtcag gccctgaaca tcgtcctact tgagaatctg     2217

tcaggggaaa aagtcaaggg gagcaggagg aagagccagg agggccagag gcagagaaga     2277

gatggagtct taggggccag ggtgagcgag gggtccaggg cctagaggtg cttcctgggg     2337

gcgggggaat gcagccagtg tccccctccc ctcttccacc ccagctccag ccctggtctt     2397

gtcttttcat ccctcttccc cacgacagaa gaagttgtgg ccctggccat gtcatcgtgt     2457

tcctgtgtcc cctgcatgta ccccaccctc caccccttcc ttttgcgcgg accccattac     2517

aataaatttt aaataaaatc ctg                                             2540


<210>  33
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Phe Pro Val Phe Pro Cys Thr Leu Leu Ala Pro Pro Phe Pro Val 
1               5                   10                  15      


Leu Gly Leu Asp Ser Arg Gly Val Gly Gly Leu Met Asn Ser Phe Pro 
            20                  25                  30          


Pro Pro Gln Gly His Ala Gln Asn Pro Leu Gln Val Gly Ala Glu Leu 
        35                  40                  45              


Gln Ser Arg Phe Phe Ala Ser Gln Gly Cys Ala Gln Ser Pro Phe Gln 
    50                  55                  60                  


Ala Ala Pro Ala Pro Pro Pro Thr Pro Gln Ala Pro Ala Ala Glu Pro 
65                  70                  75                  80  


Leu Gln Val Asp Leu Leu Pro Val Leu Ala Ala Ala Gln Glu Ser Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ala Ala Ala 
            100                 105                 110         


Pro Pro Ala Pro Ala Ala Ala Ser Thr Val Asp Thr Ala Ala Leu Lys 
        115                 120                 125             


Gln Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Val Ser Ala Pro Ala 
    130                 135                 140                 


Ala Glu Ala Ala Pro Pro Ala Ser Ala Ala Thr Ile Ala Ala Ala Ala 
145                 150                 155                 160 


Ala Thr Ala Val Val Ala Pro Thr Ser Thr Val Ala Val Ala Pro Val 
                165                 170                 175     


Ala Ser Ala Leu Glu Lys Lys Thr Lys Ser Lys Gly Pro Tyr Ile Cys 
            180                 185                 190         


Ala Leu Cys Ala Lys Glu Phe Lys Asn Gly Tyr Asn Leu Arg Arg His 
        195                 200                 205             


Glu Ala Ile His Thr Gly Ala Lys Ala Gly Arg Val Pro Ser Gly Ala 
    210                 215                 220                 


Met Lys Met Pro Thr Met Val Pro Leu Ser Leu Leu Ser Val Pro Gln 
225                 230                 235                 240 


Leu Ser Gly Ala Gly Gly Gly Gly Gly Glu Ala Gly Ala Gly Gly Gly 
                245                 250                 255     


Ala Ala Ala Val Ala Ala Gly Gly Val Val Thr Thr Thr Ala Ser Gly 
            260                 265                 270         


Lys Arg Ile Arg Lys Asn His Ala Cys Glu Met Cys Gly Lys Ala Phe 
        275                 280                 285             


Arg Asp Val Tyr His Leu Asn Arg His Lys Leu Ser His Ser Asp Glu 
    290                 295                 300                 


Lys Pro Tyr Gln Cys Pro Val Cys Gln Gln Arg Phe Lys Arg Lys Asp 
305                 310                 315                 320 


Arg Met Ser Tyr His Val Arg Ser His Asp Gly Ala Val His Lys Pro 
                325                 330                 335     


Tyr Asn Cys Ser His Cys Gly Lys Ser Phe Ser Arg Pro Asp His Leu 
            340                 345                 350         


Asn Ser His Val Arg Gln Val His Ser Thr Glu Arg Pro Phe Lys Cys 
        355                 360                 365             


Glu Lys Cys Glu Ala Ala Phe Ala Thr Lys Asp Arg Leu Arg Ala His 
    370                 375                 380                 


Thr Val Arg His Glu Glu Lys Val Pro Cys His Val Cys Gly Lys Met 
385                 390                 395                 400 


Leu Ser Ser Ala Tyr Ile Ser Asp His Met Lys Val His Ser Gln Gly 
                405                 410                 415     


Pro His His Val Cys Glu Leu Cys Asn Lys Gly Thr Gly Glu Val Cys 
            420                 425                 430         


Pro Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        435                 440                 445             


Val Ala Ala Pro Pro Thr Ala Val Gly Ser Leu Ser Gly Ala Glu Gly 
    450                 455                 460                 


Val Pro Val Ser Ser Gln Pro Leu Pro Ser Gln Pro Trp 
465                 470                 475         


<210>  34
<211>  3723
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (35)..(601)

<400>  34
aaacccaaag cggccgccgt aggcgaaggt gaag atg gct gcc tct gcc ttt gct       55
                                      Met Ala Ala Ser Ala Phe Ala         
                                      1               5                   

ggt gca gtg aga gca gct tca gga atc cta cgg ccc ctg aat att ttg        103
Gly Ala Val Arg Ala Ala Ser Gly Ile Leu Arg Pro Leu Asn Ile Leu           
        10                  15                  20                        

gca tct tca acc tac cgc aac tgt gtc aag aat gcc tct ctt att tct        151
Ala Ser Ser Thr Tyr Arg Asn Cys Val Lys Asn Ala Ser Leu Ile Ser           
    25                  30                  35                            

gca ttg tcc act gga cgt ttt agt cat att cag aca cca gtt gtt tcc        199
Ala Leu Ser Thr Gly Arg Phe Ser His Ile Gln Thr Pro Val Val Ser           
40                  45                  50                  55            

tcc act ccc aga ctt acc aca tct gag aga aac ctg aca tgt ggg cat        247
Ser Thr Pro Arg Leu Thr Thr Ser Glu Arg Asn Leu Thr Cys Gly His           
                60                  65                  70                

acc tca gtg atc ctt aat aga atg gcc ccc gtg ctt cca agt gtc ctg        295
Thr Ser Val Ile Leu Asn Arg Met Ala Pro Val Leu Pro Ser Val Leu           
            75                  80                  85                    

aag ctg cca gtc aga tct cta aca tac ttc agt gca aga aaa ggc aag        343
Lys Leu Pro Val Arg Ser Leu Thr Tyr Phe Ser Ala Arg Lys Gly Lys           
        90                  95                  100                       

aga aag acc gtg aaa gct gtc atc gat agg ttt ctt cga ctt cat tgt        391
Arg Lys Thr Val Lys Ala Val Ile Asp Arg Phe Leu Arg Leu His Cys           
    105                 110                 115                           

ggc ctt tgg gtg agg aga aag gct ggc tat aag aaa aaa tta tgg aaa        439
Gly Leu Trp Val Arg Arg Lys Ala Gly Tyr Lys Lys Lys Leu Trp Lys           
120                 125                 130                 135           

aag aca cct gca agg aag aag cga ttg agg gaa ttt gta ttc tgc aat        487
Lys Thr Pro Ala Arg Lys Lys Arg Leu Arg Glu Phe Val Phe Cys Asn           
                140                 145                 150               

aaa acc cag agt aaa ctc tta gat aaa atg acg acg tcc ttc tgg aag        535
Lys Thr Gln Ser Lys Leu Leu Asp Lys Met Thr Thr Ser Phe Trp Lys           
            155                 160                 165                   

agg cga aac tgg tac gtt gat gat cct tat cag aag tat cat gat cga        583
Arg Arg Asn Trp Tyr Val Asp Asp Pro Tyr Gln Lys Tyr His Asp Arg           
        170                 175                 180                       

aca aac ctg aaa gta tag atcagaagtt tcacttgttt ctcagttatt               631
Thr Asn Leu Lys Val                                                       
    185                                                                   

ggatatgtat ctttgtgtac atatctttgc aaaaatggat aagtacaaaa cttgatgtaa      691

attgtaccaa tgaatacgta aacatacagt gacaacatta aacttagaaa agttttaaaa      751

cttaatggat cagactttgc cagatttggt tagggaaaca gaaatttaga atggtgcatt      811

atttttaaca aatggtattg gcttaactag ttgtttcagt tatgctcttt tagttgcaag      871

gaatctcaag tgggacaaac ataaaaagac tcaaaagcta caagttagct caagcaatgt      931

gacattattt caaggatatg tgccagggaa ttcaggaacc acctcaccaa ccccatctcc      991

cactcagaaa tcacctccca gcctcaggaa gagtagaaat tgggtggtgc tcctcagcag     1051

gggaaggtgg atgtttaggc ttgggctctg catgcatgtg acttgcttct ttttgcattg     1111

ttaactccat tctctctatt caccaacttc tctacacagc ttttgcatac ttacagtttc     1171

tgttcctttg taataacttt aacttgcacc tttgaggttc ttttctacat gatgaccttc     1231

agctcctgct gctagtctcc aattgccaag ggaatttaac tgggccagac taccttttta     1291

tactaggtct ggttgggtca ttgtctagag tagggattgg ctgtccttaa gtcaggagcc     1351

cgctttgtat tagcaggttt gcatgcagca aaaaaacagt tatgtgagca gtttcacttg     1411

gaggttcaca tggggtggca gcacacttaa catctaacac accaggttca ttgtgttcat     1471

aacacttgtc atttactgta acaacatttt ttcataggag agtaaatagc ccttcagcat     1531

gctcattcat gaaacagaag aggctgtaca agtgaagaca agggcttttt atgcaagttt     1591

tgaaagatag gtatttattt tttctagaga caggagtttt gctctgttgc ccaggctgga     1651

gtgcagtggt gcaatcatag ctcattgaag cctcgcactc ctgggctcaa gtggtcctcc     1711

tgcctcagct tactgagtaa ggatatgtat ttcttaaaag ttagtttatc cacttcagat     1771

ttcatgtttt catttgtaag gataaacttt tcccacaaat tttcaacaat cattgtagaa     1831

actaaggggg agaaagtaat ctcagttgtt ttagaaacga aaaagttaag cattgtttac     1891

ttgaagtggg cagggaagca gcactgagta aagttcaatt gagtggttac agtctagggc     1951

agtggttccc aactctccga tcagaatcat ctgggaagca ttttcaaaca gcaaagtact     2011

ttgaaaacca ttattaaata gaattatgca tgaattactg tttcagatcc tttaatgtgg     2071

tagttggtaa taataagatg aaattcctct gttgttagta aaattatgaa attgaagttc     2131

tgcagcatgt caggccagga ttattaggga gattcctcga aactagtgtg tgtttattaa     2191

aaggagaaag gataacaata gaatgttcta aaaccagaag tccaagtgcg tgtctactta     2251

tgggaccaat aaataaagaa cagacatttg atttgaggtg aggtaaaagc ctgaaacatg     2311

gaatggcatt ctgttttgat ggattttcat ttcttcgcac ttctgagacg gcaaagccaa     2371

ccacttagaa gccttccaca tctttgtcac ctgcctggct cctgctctct gatgtacctc     2431

tgggtagtga gatggaaatg gtgcctgcag aagttgggga gaaggatact tttgcacagc     2491

ctccatgatg tctttattgc aaatatggat gacaagggtc tctgttacag gggcctcaga     2551

gcaccttcgt ttctcctcta gaccagggac aggtgtagag ataaggactg gcaaccagag     2611

cctcagcatc caaagatgga ctgaagtggg atggctgaca ggcacataac ttacgggaaa     2671

gggaatttca tacatacgat ttttgttttg tgggtaggag ggcttatcat caacactgat     2731

tttataatct gacaataaat gtctttcatt aaagagttta cctaaatgat gttcgattat     2791

atgtataatt tataaaatat ttatgtatag tttgtttatt caggtatatg tataatttat     2851

tgaacaccta ctatgtccca gcatatctac aaaactgggt acatacatac tgtctaactg     2911

ctaatccaca tttccagtct tacaaaggac ataatgatta gttaagccct aatttagatt     2971

tgaggaaact gaagctgaga gagggttaag taaattaccc aaagtacagc taataagacc     3031

cagaatctca gtctcactcc ttgggatcct gtgtatttcc ctgagtcttc taacatatga     3091

aaattcatat ctaaatcaac aagtgactgt aatctggtac tataaatact aaataaacac     3151

ttcttcataa cactgtacca attcagcttt taaattttat tactttgctt tcctgtcctt     3211

tgccaactct taacctagtt aatcctagtt ctgttgacat tggaccaggc tcagtaaata     3271

aacgaatgga tttccagcct ttttttccca tctgttcctg cttttagtcc tctgaatctg     3331

cttcttttct tactgctgct ttattttaca gtgattttgt caaacataga atacaggact     3391

aaaaatgcaa agaaattggg tctgtgttta attttgatgt ttcaaatttt gagcttccaa     3451

gtctttgtgg ccacccaatg aagtttgagt ctgcctgttc agatgtgaaa ggtaagggct     3511

gcagcaggtt taagggtggc ccttcaccac cctgttgtca cctgcacagg cactccccca     3571

tttgcagatg aagaaatgtt cagagaagaa aaatgatgga ccaaacgtct gtttgcacaa     3631

ttgaaactct accagtggac tattctattt tcacagctac ctagtttctg ccgatgattt     3691

ttttaaatgt gaaataaaca gtgatacttt ca                                   3723


<210>  35
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Ala Ser Ala Phe Ala Gly Ala Val Arg Ala Ala Ser Gly Ile 
1               5                   10                  15      


Leu Arg Pro Leu Asn Ile Leu Ala Ser Ser Thr Tyr Arg Asn Cys Val 
            20                  25                  30          


Lys Asn Ala Ser Leu Ile Ser Ala Leu Ser Thr Gly Arg Phe Ser His 
        35                  40                  45              


Ile Gln Thr Pro Val Val Ser Ser Thr Pro Arg Leu Thr Thr Ser Glu 
    50                  55                  60                  


Arg Asn Leu Thr Cys Gly His Thr Ser Val Ile Leu Asn Arg Met Ala 
65                  70                  75                  80  


Pro Val Leu Pro Ser Val Leu Lys Leu Pro Val Arg Ser Leu Thr Tyr 
                85                  90                  95      


Phe Ser Ala Arg Lys Gly Lys Arg Lys Thr Val Lys Ala Val Ile Asp 
            100                 105                 110         


Arg Phe Leu Arg Leu His Cys Gly Leu Trp Val Arg Arg Lys Ala Gly 
        115                 120                 125             


Tyr Lys Lys Lys Leu Trp Lys Lys Thr Pro Ala Arg Lys Lys Arg Leu 
    130                 135                 140                 


Arg Glu Phe Val Phe Cys Asn Lys Thr Gln Ser Lys Leu Leu Asp Lys 
145                 150                 155                 160 


Met Thr Thr Ser Phe Trp Lys Arg Arg Asn Trp Tyr Val Asp Asp Pro 
                165                 170                 175     


Tyr Gln Lys Tyr His Asp Arg Thr Asn Leu Lys Val 
            180                 185             


<210>  36
<211>  3618
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (59)..(1414)

<400>  36
aattgtaaag agagagaagt ggataaatca gtgctgcttt ctttaggacg aaagaagt         58

atg gag cag tgg gat cac ttt cac aat caa cag gag gac act gat agc        106
Met Glu Gln Trp Asp His Phe His Asn Gln Gln Glu Asp Thr Asp Ser           
1               5                   10                  15                

tgc tcc gaa tct gtg aaa ttt gat gct cgc tca atg aca gct ttg ctt        154
Cys Ser Glu Ser Val Lys Phe Asp Ala Arg Ser Met Thr Ala Leu Leu           
            20                  25                  30                    

cct ccg aat cct aaa aac agc cct tcc ctt caa gag aaa ctg aag tcc        202
Pro Pro Asn Pro Lys Asn Ser Pro Ser Leu Gln Glu Lys Leu Lys Ser           
        35                  40                  45                        

ttc aaa gct gca ctg att gcc ctt tac ctc ctc gtg ttt gca gtt ctc        250
Phe Lys Ala Ala Leu Ile Ala Leu Tyr Leu Leu Val Phe Ala Val Leu           
    50                  55                  60                            

atc cct ctc att gga ata gtg gca gct caa ctc ctg aag tgg gaa acg        298
Ile Pro Leu Ile Gly Ile Val Ala Ala Gln Leu Leu Lys Trp Glu Thr           
65                  70                  75                  80            

aag aat tgc tca gtt agt tca act aat gca aat gat ata act caa agt        346
Lys Asn Cys Ser Val Ser Ser Thr Asn Ala Asn Asp Ile Thr Gln Ser           
                85                  90                  95                

ctc acg gga aaa gga aat gac agc gaa gag gaa atg aga ttt caa gaa        394
Leu Thr Gly Lys Gly Asn Asp Ser Glu Glu Glu Met Arg Phe Gln Glu           
            100                 105                 110                   

gtc ttt atg gaa cac atg agc aac atg gag aag aga atc cag cat att        442
Val Phe Met Glu His Met Ser Asn Met Glu Lys Arg Ile Gln His Ile           
        115                 120                 125                       

tta gac atg gaa gcc aac ctc atg gac aca gag cat ttc caa aat ttc        490
Leu Asp Met Glu Ala Asn Leu Met Asp Thr Glu His Phe Gln Asn Phe           
    130                 135                 140                           

agc atg aca act gat caa aga ttt aat gac att ctt ctg cag cta agt        538
Ser Met Thr Thr Asp Gln Arg Phe Asn Asp Ile Leu Leu Gln Leu Ser           
145                 150                 155                 160           

acc ttg ttt tcc tca gtc cag gga cat ggg aat gca ata gat gaa atc        586
Thr Leu Phe Ser Ser Val Gln Gly His Gly Asn Ala Ile Asp Glu Ile           
                165                 170                 175               

tcc aag tcc tta ata agt ttg aat acc aca ttg ctt gat ttg cag ctc        634
Ser Lys Ser Leu Ile Ser Leu Asn Thr Thr Leu Leu Asp Leu Gln Leu           
            180                 185                 190                   

aac ata gaa aat ctg aat ggc aaa atc caa gag aat acc ttc aaa caa        682
Asn Ile Glu Asn Leu Asn Gly Lys Ile Gln Glu Asn Thr Phe Lys Gln           
        195                 200                 205                       

caa gag gaa atc agt aaa tta gag gag cgt gtt tac aat gta tca gca        730
Gln Glu Glu Ile Ser Lys Leu Glu Glu Arg Val Tyr Asn Val Ser Ala           
    210                 215                 220                           

gaa att atg gct atg aaa gaa gaa caa gtg cat ttg gaa cag gaa ata        778
Glu Ile Met Ala Met Lys Glu Glu Gln Val His Leu Glu Gln Glu Ile           
225                 230                 235                 240           

aaa gga gaa gtg aaa gta ctg aat aac atc act aat gat ctc aga ctg        826
Lys Gly Glu Val Lys Val Leu Asn Asn Ile Thr Asn Asp Leu Arg Leu           
                245                 250                 255               

aaa gat tgg gaa cat tct cag acc ttg aga aat atc act tta att caa        874
Lys Asp Trp Glu His Ser Gln Thr Leu Arg Asn Ile Thr Leu Ile Gln           
            260                 265                 270                   

ggt cct cct gga ccc ccg ggt gaa aaa gga gat cga ggt ccc act gga        922
Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Asp Arg Gly Pro Thr Gly           
        275                 280                 285                       

gaa agt ggt cca cga gga ttt cca ggt cca ata ggt cct ccg ggt ctt        970
Glu Ser Gly Pro Arg Gly Phe Pro Gly Pro Ile Gly Pro Pro Gly Leu           
    290                 295                 300                           

aaa ggt gat cgg gga gca att ggc ttt cct gga agt cga gga ctc cca       1018
Lys Gly Asp Arg Gly Ala Ile Gly Phe Pro Gly Ser Arg Gly Leu Pro           
305                 310                 315                 320           

gga tat gcc gga agg cca gga aat tct gga cca aaa ggc cag aaa ggg       1066
Gly Tyr Ala Gly Arg Pro Gly Asn Ser Gly Pro Lys Gly Gln Lys Gly           
                325                 330                 335               

gaa aag ggg agt gga aac aca tta act cca ttt acg aaa gtt cga ctg       1114
Glu Lys Gly Ser Gly Asn Thr Leu Thr Pro Phe Thr Lys Val Arg Leu           
            340                 345                 350                   

gtc ggt ggg agc ggc cct cac gag ggg agg gtg gag ata ctc cac agc       1162
Val Gly Gly Ser Gly Pro His Glu Gly Arg Val Glu Ile Leu His Ser           
        355                 360                 365                       

ggc cag tgg ggt aca att tgt gac gat cgc tgg gaa gtg cgc gtt gga       1210
Gly Gln Trp Gly Thr Ile Cys Asp Asp Arg Trp Glu Val Arg Val Gly           
    370                 375                 380                           

cag gtc gtc tgt agg agc ttg gga tac cca ggt gtt caa gcc gtg cac       1258
Gln Val Val Cys Arg Ser Leu Gly Tyr Pro Gly Val Gln Ala Val His           
385                 390                 395                 400           

aag gca gct cac ttt gga caa ggt act ggt cca ata tgg ctg aat gaa       1306
Lys Ala Ala His Phe Gly Gln Gly Thr Gly Pro Ile Trp Leu Asn Glu           
                405                 410                 415               

gtg ttt tgt ttt ggg aga gaa tca tct att gaa gaa tgt aaa att cgg       1354
Val Phe Cys Phe Gly Arg Glu Ser Ser Ile Glu Glu Cys Lys Ile Arg           
            420                 425                 430                   

caa tgg ggg aca aga gcc tgt tca cat tct gaa gat gct gga gtc act       1402
Gln Trp Gly Thr Arg Ala Cys Ser His Ser Glu Asp Ala Gly Val Thr           
        435                 440                 445                       

tgc act tta taa tgcatcatat tttcattcac aactatgaaa tcgctgctca           1454
Cys Thr Leu                                                               
    450                                                                   

aaaatgattt tattaccttg ttcctgtaaa atccatttaa tcaatattta agagattaag     1514

aatattgccc aaataatatt ttagattaca ggattaatat attgaacacc ttcatgctta     1574

ctattttatg tctatattta aatcatttta acttctatag gtttttaaat ggaattttct     1634

aatataatga cttatatgct gaattgaaca ttttgaagtt tatagcttcc agattacaaa     1694

ggccaagggt aatagaaatg cataccagta attggctcca attcataata tgttcaccag     1754

gagattacaa ttttttgctc ttcttgtctt tgtaatctat ttagttgatt ttaattactt     1814

tctgaataac ggaagggatc agaagatatc ttttgtgcct agattgcaaa atctccaatc     1874

cacacatatt gttttaaaat aagaatgtta tccaactatt aagatatctc aatgtgcaat     1934

aacttgtgta ttagatatca atgttaatga tatgtcttgg ccactatgga ccagggagct     1994

tatttttctt gtcatgtact gacaactgtt taattgaatc atgaagtaaa ttgaaagcag     2054

gacatatgag aaaactgacc atcagtatat ttgtccagat aattggtgga tcaaaaatgc     2114

cacttaacag gaagtttagt ttgttatgca ctttaaatgg aataattagc ttgttacaat     2174

tctaggacat ggtgtttaaa atttaaatct gattaatcca ttttaacaaa caatgcaaac     2234

atcttcagtg cagaaggaag agtggtttca actgtttgga gtcttttatg aagtcagtca     2294

acatttacaa ccaaagggcg gggggggggg tggggggtgc gtctttagtc ctaaagggac     2354

aataactctg agcatgcccc aaaaaagtag tttagcaacc ttttgttggt agtcaaccca     2414

tccccagggc catagtgtag agtgtgaaaa gctaccctga aacccagtaa ttctaccctg     2474

aaagtgactg cctgcagaaa gaccagcagt tgatattaaa gcgcaaatga attcaacctc     2534

agccctgaaa ataacagaat tctgaagttt cctatgacta attcacaaaa aaagtaattg     2594

taaactagta ctattatgga attactctac tgttctttct ttaatagtgg caaatgaaag     2654

cataagctta agcatttttt catattctga agtctcacca cacataataa ccaagtggta     2714

gactcacagc cgtccaactt aaaaaggcaa aaccttacct tggaattgga attactgtaa     2774

acagcctact gaaaatgcat ttttatcatg taacattctt ctacttgttt aacattgctg     2834

attttctctg gcagcataat tttgtggtta agagaatgaa ttctgaatgt acactttctg     2894

tctcaaaccc tggctgtaat ttcagctagt taataattct ttgtgttcag ttccactatc     2954

taggtatttt cttcaaaagg taaatacaat ggtttctgaa agaatcattt gcattatcag     3014

cctgtttggg atgtctgaga tcagtgcctc tgggttgtta atactgtatt gctgtatggt     3074

atatgtatgc tgatttacta cttatgcgta agtggtatgc atgggatgtc tgaaatcagt     3134

gcctatgggt tgtcaatagt attaactatt agtgttaact gttagtatta actattagta     3194

ttattaacac taataatagt actattacta ttactatttt tattttaaaa taaaatttac     3254

ctttaaaata ataatagtac tattgctagt actagtacta ttgctattac tagtactatt     3314

actagtacta gtactatgac actgttaata gtactattaa caacccatag gcacttggga     3374

tgtctgagat cagtgcctat gggttgttaa tactatattg ctgtatggta tatgcatgct     3434

gatttaccac ttatgcatag atatatcttt aataagtaat ctaaaaatcc tttttgtatt     3494

tgagagaatc tactaagttc agtccagtca agaaaagaac ctaatagcac caatacaaat     3554

tgaggactta atttactttg gaatgttgaa ttgcatttgt tccattaaaa aaaacagaaa     3614

tttg                                                                  3618


<210>  37
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Glu Gln Trp Asp His Phe His Asn Gln Gln Glu Asp Thr Asp Ser 
1               5                   10                  15      


Cys Ser Glu Ser Val Lys Phe Asp Ala Arg Ser Met Thr Ala Leu Leu 
            20                  25                  30          


Pro Pro Asn Pro Lys Asn Ser Pro Ser Leu Gln Glu Lys Leu Lys Ser 
        35                  40                  45              


Phe Lys Ala Ala Leu Ile Ala Leu Tyr Leu Leu Val Phe Ala Val Leu 
    50                  55                  60                  


Ile Pro Leu Ile Gly Ile Val Ala Ala Gln Leu Leu Lys Trp Glu Thr 
65                  70                  75                  80  


Lys Asn Cys Ser Val Ser Ser Thr Asn Ala Asn Asp Ile Thr Gln Ser 
                85                  90                  95      


Leu Thr Gly Lys Gly Asn Asp Ser Glu Glu Glu Met Arg Phe Gln Glu 
            100                 105                 110         


Val Phe Met Glu His Met Ser Asn Met Glu Lys Arg Ile Gln His Ile 
        115                 120                 125             


Leu Asp Met Glu Ala Asn Leu Met Asp Thr Glu His Phe Gln Asn Phe 
    130                 135                 140                 


Ser Met Thr Thr Asp Gln Arg Phe Asn Asp Ile Leu Leu Gln Leu Ser 
145                 150                 155                 160 


Thr Leu Phe Ser Ser Val Gln Gly His Gly Asn Ala Ile Asp Glu Ile 
                165                 170                 175     


Ser Lys Ser Leu Ile Ser Leu Asn Thr Thr Leu Leu Asp Leu Gln Leu 
            180                 185                 190         


Asn Ile Glu Asn Leu Asn Gly Lys Ile Gln Glu Asn Thr Phe Lys Gln 
        195                 200                 205             


Gln Glu Glu Ile Ser Lys Leu Glu Glu Arg Val Tyr Asn Val Ser Ala 
    210                 215                 220                 


Glu Ile Met Ala Met Lys Glu Glu Gln Val His Leu Glu Gln Glu Ile 
225                 230                 235                 240 


Lys Gly Glu Val Lys Val Leu Asn Asn Ile Thr Asn Asp Leu Arg Leu 
                245                 250                 255     


Lys Asp Trp Glu His Ser Gln Thr Leu Arg Asn Ile Thr Leu Ile Gln 
            260                 265                 270         


Gly Pro Pro Gly Pro Pro Gly Glu Lys Gly Asp Arg Gly Pro Thr Gly 
        275                 280                 285             


Glu Ser Gly Pro Arg Gly Phe Pro Gly Pro Ile Gly Pro Pro Gly Leu 
    290                 295                 300                 


Lys Gly Asp Arg Gly Ala Ile Gly Phe Pro Gly Ser Arg Gly Leu Pro 
305                 310                 315                 320 


Gly Tyr Ala Gly Arg Pro Gly Asn Ser Gly Pro Lys Gly Gln Lys Gly 
                325                 330                 335     


Glu Lys Gly Ser Gly Asn Thr Leu Thr Pro Phe Thr Lys Val Arg Leu 
            340                 345                 350         


Val Gly Gly Ser Gly Pro His Glu Gly Arg Val Glu Ile Leu His Ser 
        355                 360                 365             


Gly Gln Trp Gly Thr Ile Cys Asp Asp Arg Trp Glu Val Arg Val Gly 
    370                 375                 380                 


Gln Val Val Cys Arg Ser Leu Gly Tyr Pro Gly Val Gln Ala Val His 
385                 390                 395                 400 


Lys Ala Ala His Phe Gly Gln Gly Thr Gly Pro Ile Trp Leu Asn Glu 
                405                 410                 415     


Val Phe Cys Phe Gly Arg Glu Ser Ser Ile Glu Glu Cys Lys Ile Arg 
            420                 425                 430         


Gln Trp Gly Thr Arg Ala Cys Ser His Ser Glu Asp Ala Gly Val Thr 
        435                 440                 445             


Cys Thr Leu 
    450     


<210>  38
<211>  3562
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (58)..(1782)

<400>  38
actcgccggc actcgcccgg ctcgcccgct ttcgcaccca gttcacgcgc cacagct          57

atg tgt ccc cga gcc gcg cgg gcg ccc gcg acg cta ctc ctc gcc ctg        105
Met Cys Pro Arg Ala Ala Arg Ala Pro Ala Thr Leu Leu Leu Ala Leu           
1               5                   10                  15                

ggc gcg gtg ctg tgg cct gcg gct ggc gcc tgg gag ctt acg att ttg        153
Gly Ala Val Leu Trp Pro Ala Ala Gly Ala Trp Glu Leu Thr Ile Leu           
            20                  25                  30                    

cac acc aac gac gtg cac agc cgg ctg gag cag acc agc gag gac tcc        201
His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser           
        35                  40                  45                        

agc aag tgc gtc aac gcc agc cgc tgc atg ggt ggc gtg gct cgg ctc        249
Ser Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu           
    50                  55                  60                            

ttc acc aag gtt cag cag atc cgc cgc gcc gaa ccc aac gtg ctg ctg        297
Phe Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu           
65                  70                  75                  80            

ctg gac gcc ggc gac cag tac cag ggc act atc tgg ttc acc gtg tac        345
Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr           
                85                  90                  95                

aag ggc gcc gag gtg gcg cac ttc atg aac gcc ctg cgc tac gat gcc        393
Lys Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala           
            100                 105                 110                   

atg gca ctg gga aat cat gaa ttt gat aat ggt gtg gaa gga ctg atc        441
Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile           
        115                 120                 125                       

gag cca ctc ctc aaa gag gcc aaa ttt cca att ctg agt gca aac att        489
Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile           
    130                 135                 140                           

aaa gca aag ggg cca cta gca tct caa ata tca gga ctt tat ttg cca        537
Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro           
145                 150                 155                 160           

tat aaa gtt ctt cct gtt ggt gat gaa gtt gtg gga atc gtt gga tac        585
Tyr Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr           
                165                 170                 175               

act tcc aaa gaa acc cct ttt ctc tca aat cca ggg aca aat tta gtg        633
Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val           
            180                 185                 190                   

ttt gaa gat gaa atc act gca tta caa cct gaa gta gat aag tta aaa        681
Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys           
        195                 200                 205                       

act cta aat gtg aac aaa att att gca ctg gga cat tcg ggt ttt gaa        729
Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu           
    210                 215                 220                           

atg gat aaa ctc atc gct cag aaa gtg agg ggt gtg gac gtc gtg gtg        777
Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val           
225                 230                 235                 240           

gga gga cac tcc aac aca ttt ctt tac aca ggc aat cca cct tcc aaa        825
Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys           
                245                 250                 255               

gag gtg cct gct ggg aag tac cca ttc ata gtc act tct gat gat ggg        873
Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ser Asp Asp Gly           
            260                 265                 270                   

cgg aag gtt cct gta gtc cag gcc tat gct ttt ggc aaa tac cta ggc        921
Arg Lys Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly           
        275                 280                 285                       

tat ctg aag atc gag ttt gat gaa aga gga aac gtc atc tct tcc cat        969
Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn Val Ile Ser Ser His           
    290                 295                 300                           

gga aat ccc att ctt cta aac agc agc att cct gaa gat cca agc ata       1017
Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile           
305                 310                 315                 320           

aaa gca gac att aac aaa tgg agg ata aaa ttg gat aat tat tct acc       1065
Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr           
                325                 330                 335               

cag gaa tta ggg aaa aca att gtc tat ctg gat ggc tcc tct caa tca       1113
Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser           
            340                 345                 350                   

tgc cgc ttt aga gaa tgc aac atg ggc aac ctg att tgt gat gca atg       1161
Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met           
        355                 360                 365                       

att aac aac aac ctg aga cac acg gat gaa atg ttc tgg aac cac gta       1209
Ile Asn Asn Asn Leu Arg His Thr Asp Glu Met Phe Trp Asn His Val           
    370                 375                 380                           

tcc atg tgc att tta aat gga ggt ggt atc cgg tcg ccc att gat gaa       1257
Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu           
385                 390                 395                 400           

cgc aac aat ggc aca att acc tgg gag aac ctg gct gct gta ttg ccc       1305
Arg Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val Leu Pro           
                405                 410                 415               

ttt gga ggc aca ttt gac cta gtc cag tta aaa ggt tcc acc ctg aag       1353
Phe Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr Leu Lys           
            420                 425                 430                   

aag gcc ttt gag cat agc gtg cac cgc tac ggc cag tcc act gga gag       1401
Lys Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr Gly Glu           
        435                 440                 445                       

ttc ctg cag gtg ggc gga atc cat gtg gtg tat gat ctt tcc cga aaa       1449
Phe Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Leu Ser Arg Lys           
    450                 455                 460                           

cct gga gac aga gta gtc aaa tta gat gtt ctt tgc acc aag tgt cga       1497
Pro Gly Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr Lys Cys Arg           
465                 470                 475                 480           

gtg ccc agt tat gac cct ctc aaa atg gac gag gta tat aag gtg atc       1545
Val Pro Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr Lys Val Ile           
                485                 490                 495               

ctc cca aac ttc ctg gcc aat ggt gga gat ggg ttc cag atg ata aaa       1593
Leu Pro Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys           
            500                 505                 510                   

gat gaa tta tta aga cat gac tct ggt gac caa gat atc aac gtg gtt       1641
Asp Glu Leu Leu Arg His Asp Ser Gly Asp Gln Asp Ile Asn Val Val           
        515                 520                 525                       

tct aca tat atc tcc aaa atg aaa gta att tat cca gca gtt gaa ggt       1689
Ser Thr Tyr Ile Ser Lys Met Lys Val Ile Tyr Pro Ala Val Glu Gly           
    530                 535                 540                           

cgg atc aag ttt tcc aca gga agt cac tgc cat gga agc ttt tct tta       1737
Arg Ile Lys Phe Ser Thr Gly Ser His Cys His Gly Ser Phe Ser Leu           
545                 550                 555                 560           

ata ttt ctt tca ctt tgg gca gtg atc ttt gtt tta tac caa tag           1782
Ile Phe Leu Ser Leu Trp Ala Val Ile Phe Val Leu Tyr Gln                   
                565                 570                                   

ccaaaaattc tccttgcctt taatgtgtga aactgcattt tttcaagtga gattcaaatc     1842

tgccttttag gacctggctt tgtgacagca aaaaccatct ttacaggctc ctagaagctg     1902

aaggttagag cattataaaa tgaagagaca gacatgatta ctcagggtca gcaacctagt     1962

gagttagaaa aaaaattaac atagggccct ataaggagaa agccaactat gttaagttta     2022

cgtgtccaaa ttttaatgaa attttactaa caattttaaa ccatattttt cttcttcata     2082

tccatttcta atccatcaaa cagcttatgt ttacataaaa ttttatcatt cacaaggaag     2142

ttttaagcac actgtctcat ttgatatcca caacttattt ttggtaggaa agagagatgt     2202

ttttcccacc tgtcagatga aaaaactgaa gctcaaaaag ggttgacttg accatacagc     2262

taatgctgac agatccaaga cctagaccta ggtcttttga actcaagtcc agcattctca     2322

actatatcaa gttactgttc agaatactta atatctcctc tcttcataat tatcaatagc     2382

cccaagctca tggatgacaa atctctgctt tatttcttgt ctctattttt tcactttata     2442

gctcctgtta taatagcaag tttaatggta taaacacagg ataccatcct ctcttgcaac     2502

acccatgtgc ctttgatgag tcaggtagca agctgtagta gataatgaga aaggccagag     2562

gctgcaaaag acagtcaaag gacacgagag aaaggaaggg gaagaacagg actccaggac     2622

tgttttatat tatagaaaag caagagctaa agagcattta cacatgttaa acagatactt     2682

gttaagcata gtgcctgaca cacggcatta gctgttattt tatgagattc catcagctct     2742

gcctctgtcc tctttcttct aacatgaagg tatcatgaga agagaacctt ctaacataag     2802

ctgtaattct aaacctgcac ttgtccctct ccagcaagag gctagcactg aattcattct     2862

actcatacta cacacccagt tatggaatgt ccagagttct cgaagaaaat aaatgacttt     2922

aggaagaggt atacattttt taagtcgctc tgcctccaaa tctgaacagt cactgtaaat     2982

cattcttaag cccagatatg agaacttctg ctggaaagtg ggaccctctg agtgggtggt     3042

cagaaaatac ccatgctgat gaaatgacct atgcccaaag aacaaatact taacgtggga     3102

gtggaaccac atgagcctgc tcagctctgc ataagtaatt caagaaatgg gaggcttcac     3162

cttaaaaaca gtgtgcaaat ggcagctaga ggttttgata ggaagtatgt ttgtttctta     3222

gtgtttacaa atattaagta ctcttgatac aaaatatact tttaaacttc ataacctttt     3282

tataaaagtt gttgcagcaa aataatagcc tcggttctat gcatatatgg attagctata     3342

aaaaatgtca ataagattgt acaaggaaaa ttagagaaag tcacatttag ggtttatttt     3402

ttacacttgg ccagtaaaat agggtaaatc ctattagaat tttttaaaga acttttttta     3462

agtttcctaa atctgtgtgt gtattgtgaa gtggtataag aaatgacttt gaaccacttt     3522

gcaattgtag attcccaaca ataaaattga agataagctc                           3562


<210>  39
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Cys Pro Arg Ala Ala Arg Ala Pro Ala Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Gly Ala Val Leu Trp Pro Ala Ala Gly Ala Trp Glu Leu Thr Ile Leu 
            20                  25                  30          


His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser 
        35                  40                  45              


Ser Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu 
    50                  55                  60                  


Phe Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu 
65                  70                  75                  80  


Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr 
                85                  90                  95      


Lys Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala 
            100                 105                 110         


Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile 
        115                 120                 125             


Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile 
    130                 135                 140                 


Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro 
145                 150                 155                 160 


Tyr Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr 
                165                 170                 175     


Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val 
            180                 185                 190         


Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys 
        195                 200                 205             


Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu 
    210                 215                 220                 


Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val 
225                 230                 235                 240 


Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys 
                245                 250                 255     


Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ser Asp Asp Gly 
            260                 265                 270         


Arg Lys Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly 
        275                 280                 285             


Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn Val Ile Ser Ser His 
    290                 295                 300                 


Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile 
305                 310                 315                 320 


Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr 
                325                 330                 335     


Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser 
            340                 345                 350         


Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met 
        355                 360                 365             


Ile Asn Asn Asn Leu Arg His Thr Asp Glu Met Phe Trp Asn His Val 
    370                 375                 380                 


Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu 
385                 390                 395                 400 


Arg Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val Leu Pro 
                405                 410                 415     


Phe Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr Leu Lys 
            420                 425                 430         


Lys Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr Gly Glu 
        435                 440                 445             


Phe Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Leu Ser Arg Lys 
    450                 455                 460                 


Pro Gly Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr Lys Cys Arg 
465                 470                 475                 480 


Val Pro Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr Lys Val Ile 
                485                 490                 495     


Leu Pro Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys 
            500                 505                 510         


Asp Glu Leu Leu Arg His Asp Ser Gly Asp Gln Asp Ile Asn Val Val 
        515                 520                 525             


Ser Thr Tyr Ile Ser Lys Met Lys Val Ile Tyr Pro Ala Val Glu Gly 
    530                 535                 540                 


Arg Ile Lys Phe Ser Thr Gly Ser His Cys His Gly Ser Phe Ser Leu 
545                 550                 555                 560 


Ile Phe Leu Ser Leu Trp Ala Val Ile Phe Val Leu Tyr Gln 
                565                 570                 


<210>  40
<211>  8991
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (241)..(1263)

<400>  40
actttccgcg cggcggaaga gcgcgcgcca gcttcggcac acctgggagc cggatcccag       60

ccctacgcct cgtcccctac aagctcctcc aagccccgcc ggctgctgtg ggagcggcgg      120

ccgtccctct cctggaggtc gtctcctggc atcctcgggg ccgcaggaag gaagaggagg      180

cagcggccgg agccctggtg ggcggcctga ggtgagagcc cgaccggccc ctttgggaat      240

atg gcg acc ggt ggc tac cgg acc agc agc ggc ctc ggc ggc agc acc        288
Met Ala Thr Gly Gly Tyr Arg Thr Ser Ser Gly Leu Gly Gly Ser Thr           
1               5                   10                  15                

aca gac ttc ctg gag gag tgg aag gcg aaa cgc gag aag atg cgc gcc        336
Thr Asp Phe Leu Glu Glu Trp Lys Ala Lys Arg Glu Lys Met Arg Ala           
            20                  25                  30                    

aag cag aac ccc ccg ggc ccg gcc ccc ccg gga ggg ggc agc agc gac        384
Lys Gln Asn Pro Pro Gly Pro Ala Pro Pro Gly Gly Gly Ser Ser Asp           
        35                  40                  45                        

gcc gct ggg aag ccc ccc gcg ggg gct ctg ggc acc ccg gcg gcc gcc        432
Ala Ala Gly Lys Pro Pro Ala Gly Ala Leu Gly Thr Pro Ala Ala Ala           
    50                  55                  60                            

gct gcc aac gag ctc aac aac aac ctc ccg ggc ggc gcg ccg gcc gca        480
Ala Ala Asn Glu Leu Asn Asn Asn Leu Pro Gly Gly Ala Pro Ala Ala           
65                  70                  75                  80            

cct gcc gtc ccc ggt ccc ggg ggc gtg aac tgc gcg gtc ggc tcc gcc        528
Pro Ala Val Pro Gly Pro Gly Gly Val Asn Cys Ala Val Gly Ser Ala           
                85                  90                  95                

atg ctg acg cgg gcg gcc ccc ggc ccg cgg cgg tcg gag gac gag ccc        576
Met Leu Thr Arg Ala Ala Pro Gly Pro Arg Arg Ser Glu Asp Glu Pro           
            100                 105                 110                   

cca gcc gcc tct gcc tcg gct gca ccg ccg ccc cag cgt gac gag gag        624
Pro Ala Ala Ser Ala Ser Ala Ala Pro Pro Pro Gln Arg Asp Glu Glu           
        115                 120                 125                       

gag ccg gac ggc gtc cca gag aag ggc aag agc tcg ggc ccc agt gcc        672
Glu Pro Asp Gly Val Pro Glu Lys Gly Lys Ser Ser Gly Pro Ser Ala           
    130                 135                 140                           

agg aaa ggc aag ggg cag atc gag aag agg aag ctg cgg gag aag cgg        720
Arg Lys Gly Lys Gly Gln Ile Glu Lys Arg Lys Leu Arg Glu Lys Arg           
145                 150                 155                 160           

cgc tcc acc ggc gtg gtc aac atc cct gcc gca gag tgc tta gat gag        768
Arg Ser Thr Gly Val Val Asn Ile Pro Ala Ala Glu Cys Leu Asp Glu           
                165                 170                 175               

tac gaa gat gat gaa gca ggg cag aaa gag cgg aaa cga gaa gat gca        816
Tyr Glu Asp Asp Glu Ala Gly Gln Lys Glu Arg Lys Arg Glu Asp Ala           
            180                 185                 190                   

att aca caa cag aac act att cag aat gaa gct gta aac tta cta gat        864
Ile Thr Gln Gln Asn Thr Ile Gln Asn Glu Ala Val Asn Leu Leu Asp           
        195                 200                 205                       

cca ggc agt tcc tat ctg cta cag gag cca cct aga aca gtt tca ggc        912
Pro Gly Ser Ser Tyr Leu Leu Gln Glu Pro Pro Arg Thr Val Ser Gly           
    210                 215                 220                           

aga tat aaa agc aca acc agt gtc tct gaa gaa gat gtc tca agt aga        960
Arg Tyr Lys Ser Thr Thr Ser Val Ser Glu Glu Asp Val Ser Ser Arg           
225                 230                 235                 240           

tat tct cga aca gat aga agt ggg ttc cct aga tat aac agg gat gca       1008
Tyr Ser Arg Thr Asp Arg Ser Gly Phe Pro Arg Tyr Asn Arg Asp Ala           
                245                 250                 255               

aat gtt tca ggt act ctg gtt tca agt agc aca ctg gaa aag aaa att       1056
Asn Val Ser Gly Thr Leu Val Ser Ser Ser Thr Leu Glu Lys Lys Ile           
            260                 265                 270                   

gaa gat ctt gaa aag gaa gta gta aga gaa aga caa gaa aac cta aga       1104
Glu Asp Leu Glu Lys Glu Val Val Arg Glu Arg Gln Glu Asn Leu Arg           
        275                 280                 285                       

ctt gtg aga ctg atg caa gat aaa gag gaa atg att gga aaa ctc aaa       1152
Leu Val Arg Leu Met Gln Asp Lys Glu Glu Met Ile Gly Lys Leu Lys           
    290                 295                 300                           

gaa gaa att gat tta tta aat aga gac cta gat gac ata gaa gat gaa       1200
Glu Glu Ile Asp Leu Leu Asn Arg Asp Leu Asp Asp Ile Glu Asp Glu           
305                 310                 315                 320           

aat gaa cag cta aag cag gaa aat aaa act ctt ttg aaa gtt gtg ggt       1248
Asn Glu Gln Leu Lys Gln Glu Asn Lys Thr Leu Leu Lys Val Val Gly           
                325                 330                 335               

cag ctg acc agg tag aggattcaag actcaatgtg gaaaaaatat tttaaactac       1303
Gln Leu Thr Arg                                                           
            340                                                           

tgattgaatg ttaatggtca atgctagcac aatattccta tgctgcaata cattaaaata     1363

actaagcaag tatatttatt tctagcaaac agatgtttgt tttcaaaata cttctttttc     1423

attattggtt ttaaaaaagc attatccttt tatctcacaa ataagtaata tctttcagtt     1483

attaaatgat agataatgcc tttttggttt tgtgtggtat tcaactaata catggtttaa     1543

agtcacagcc gtttgaatat attttatctt ggtagtacat tttctccctt aggaatatac     1603

atagtctttg tttacatgag ttcaaatact tttgggatgt taccttcaca tgtcctatta     1663

ctgatgtgtg caacctttta tgtgttgatg actcactcat aaaggttttt gtctactgtc     1723

atttgttctt tccacttatt ctaagcattt agagtaatag agtcatactt ttttataaca     1783

gcaacctttt aaaaggaaag ctcttataaa gtcactgtca tgttttagtt gactaaatat     1843

aaatttaaga gaatacttga attgtgctat agtaaataaa aatttactat tttgtgtttg     1903

aatattgaaa aattgaatca ctttaactcc tgaaaaacat acaattgtaa tttcaatgta     1963

aaatttctta tgtaggtact accttttttt atcgttccaa ggtttgctag tgaacacagg     2023

atattttaaa agttttttat tcttcgggcc tggaaagtgt acaaagtcag tgtaggagaa     2083

aaaaatccat atttttatat tagcatgcac actaaaaacc aaaatattat tcatacttaa     2143

aacattcata caaaacaata tgtaagcaga aatagtacta aaatactttg cctaatttct     2203

aagttgaaga ataacactgg gacacagttt tttcatatga gagaatattc cgctatttca     2263

aatttaaggg attttcttcc taacattgaa attttaaaaa cagagttact tctaaataat     2323

tatacagatt ttttcttcta ttaaatatta ttatttagaa ttgtttttgt attacatatt     2383

catgttaaga accccgtctt cccttaaaat acattaaaat tatgacattt ttgctttgtg     2443

attgaatttc aaatagcagt atggtatcct tttatctagt taatatatga aagtggcttg     2503

aatatagtca aatccatttt aggtactcta ctgacttttt ccttcacttg ccaagccctt     2563

ttattgttca ctgttagaaa aatagagaag gtgagacagc tgggggaaaa tgtggagtaa     2623

atgataatca aatgttgaat tctaaaagtc tctacattta cctaggttgg ctttctcccc     2683

cagttcagaa gtttccagct tggccaatca tcagaatcac ttgaggaact tagaaagaac     2743

tccctggctg tagctcctat gtaggtttag gttgagactc tggattccac aatttttaaa     2803

ggttaccatc tgaggtttct gatcatagtc tacttttgaa gcagctgctg ctgtttcttt     2863

attccattga acaccctgga attgacataa ttttatctat cagcatttct ccccttttag     2923

tttatttaat aattaacccg gtctccaggg cagttttcat atgaccatgt gtatattcac     2983

tgctcacgaa aaagtttaat gttagattac caaatttaat atagttacag aattactgca     3043

taagggcttc ccttcttgga gactcttacc cagcatggga acagtgatct gcccacatga     3103

cagggtggta tgccaggcat agttaactgc ttttggttgt gaggtactca tcttccttta     3163

gttaccctta gttatgtggc acacatgtcc ttattgccta gttcgtcatc cacactttgg     3223

atcttgtgaa aatgctgtta gtatccaacc ttaaaatata ttagtatatg ggtttttatt     3283

aaaagaatta ctttgaattt tctatttaat tcatatgtaa ataaaggaac atttcatttc     3343

acttaaaaaa attatatcag ttattaggct gggtgcagtg gctcatgcct gtaatcccag     3403

cactttggga ggccaaggcg ggtggattac cagagttcgg gagtttgaga ccagcttgac     3463

caacatggag aaaccccgtc tctactaaaa atacaaaatt agccaggtgt ggtggcgcat     3523

gcctgtaatc ctggctactc aggaggctga ggcaggagaa tcgcttgaaa acccaggaga     3583

cagaggttgc ggtgagctga gattgcgcca ttgtactcca gcctgggcaa gaagagcgaa     3643

actctgtctc caaaaaaaaa aaaaaaaaaa ttattaatac ttttaaagac tgagctgttt     3703

aagaattttt tggggaacat ttctagcagt gatttttttg gcctttaatg atagcgtaaa     3763

gacaggagcc ttacaactta ggcaaagcat ttcacatgca gtccttcttc catctcaaaa     3823

tatgtactta ttttacatac agaattttac actaaccatt gaaaaataaa gtaggatctg     3883

ctacagtttc acctgaaaat ttataaaaag tgttgagatt ggtagaaggt agtttttaag     3943

tacatgtgca ctaccctaaa agacttgtct attgtcaata aagtgttagt atttgtgaaa     4003

ttattattcc tgttcagaaa tactatttct taaatctcct gggaatttgt ggcataataa     4063

agcacattca aagttctaat gtatttatga gctcattttc aaaatagtaa gtttgtcatc     4123

tttaaaatga acatgacttg cctccttgat ttctgaaatg aattaattga agattgctat     4183

agtaatcttt atttcatctt tctagagttg ttgacaattt tattatacaa cagttaccat     4243

tagagaagga gggaagggct tttgggtgtg tatttatagg tactaaggga tttactaaat     4303

atagtagatt agcactgtca cacttgttca agtagtttca aacatagaaa attaagtatc     4363

aggtatgtgg agcaatgtag tttttttttt tcttcagttt aaaaaatttt taattgtggt     4423

agaagcaatg tattcttaag gtgaaaaacc tacctcggtt acatgtggtt tgtgtttttt     4483

ggattaatct ggattttata attagaaata aaaatgtaag attttgaatc cacttaattt     4543

cttgaaaata gtacaagtca gtgtaataga gaagcattca tatattcaac actgtaagac     4603

aaaacagcag agaccttgga tttgataatt gatctgatat cctggacagt attcatatgt     4663

acagtgatag gtatctttct ttggagtttt ttttttgtgc atatgtgtat agttttatgg     4723

gttctgagtt ggtgaccagt aagttgcatg tagtgctggc acttacttaa taactattca     4783

tgatattgtt aataacttgt tataggattg tattcccaat tacagtctct aagattgtaa     4843

ttgatattat ctgagaggta gtgtgacaac tttcttttgt tgttacatta agccgaaaac     4903

ataatactaa tagacaacta acagtttgct tatcaggcac atcaactaag gcacctcccc     4963

ccatgctaag tttctcctgg atatatggaa gttgattgtt tcccagttta aaaacttgaa     5023

ctaatatctc ctaagaaaat ctgagtccat attgttttta ttttacttag ctagaatctc     5083

atagcatgtt aaagtcatat ccttatcccc actaaaaata actatgtcta tgtgagagga     5143

atatagtatg tgggagctgt attaaatact attacaggtg ttacagaatc tttaaataaa     5203

tggacatgga ccaactttcc atctagtagt gtacgatcta tatagtgcat gtcagtagca     5263

caaaatgcag tcttagcatt agcctgtcta atctgaatag tttactcaaa agtacttctt     5323

tgtgttaagt attcagccac tgtttttaga tctagttaat aggttctatt taatttgcta     5383

caacatttac tgaatggtgg agtgaaaaaa ctgatgcata ctgggaaata tctaccattt     5443

tttaaagata atgttaatta ggaaaagaac acttttaagg aatttatagc agtgatgaaa     5503

tgaattcagt tatatcagat acaccaaact gttgatggta tttaaatgtg acttcaagtt     5563

agtatttctg tatatattat tgattactgg tttgttttta gatatgtaag tctgttctaa     5623

tctacagttc acatatcgac agttactctg gtaataatag aatgttagtg atgatcactt     5683

ggtggatgtt gattaagtgc ctgtgttttg tttcctcctc tggataccaa ataggtgtat     5743

gctacttttt tggtgaactt atttcttgga agatttggct atgctattca gggtttttat     5803

tcttatgttt ttcttctaaa tttaagtagc atcctgctgc taccatatta aagctaaaat     5863

ttaacttttg ctgaagaatc agctaattca ggtaatccaa atatttgtgg aaaaacatct     5923

ggataattta ttgaacacat tagtattgtg ttagacagct ttgatcattc ccatttcata     5983

ggtttttatt gtggaatagt caacttaata tagattcact ttcaatttgc atgtataaag     6043

taatactcaa taaaattttt ttcatttatt tttcaacagt ggttattttt tttcttcctg     6103

tactatcagt aaaatcctga ctatgagttt tacttttgaa gctaaaggat aatgctggta     6163

atctaattat gtacctctta cagaaaccat atgcagcact ttaaaaatct ttatttggta     6223

tattatttta ggtggacaat gatttaagac tcaaagccat catattaagg tctaaataca     6283

ttagtggtgg ggtttctcga ataaatgagg aagtgcacaa aagttcagcc tgactgaaaa     6343

ttttaattgt gttttaaaac tacatgaata atttcttgat tcaaaatcag aactcttata     6403

aactaaatct gatggtgtcc aaagaatttc aggtccttca aagtttgtaa aagataagta     6463

ggggcctagg aatataaaaa tttagacttt tttagtaaat ggtttacata accttttgtc     6523

ttaatttgtc attcttcata cacaggcaca agctaatcag tcttctctac ttctagaact     6583

ctaaatcttc tcagtaatgt catacaagtc taacaagagg aaaagcatcc ttaagtcagt     6643

ctatttagat aaactcttca agtccctata taaggacgta ttccactagc aagccagtaa     6703

atttttccaa ggtcacataa tcttacatga aatggaacct ttcatcttag acttcatcaa     6763

actcaatttt ttcccttcta gattcacttt gtgtttatgc atgcatgcac gcgtgcacac     6823

aattctatca gcagctgtaa actacccaca tattttctta atctcatttt ttcagttttt     6883

cttcatcttt aaaagaggtt acatttcatt cctggtcaac tcttaaaaag aattatgtaa     6943

tgttgggcct tcatattaaa gagagagact ggttataaga tcctttacag tccattcatt     7003

ttattctgat gtctaaccag atagacacta gcaagcaaaa cttccctctt aatcctggac     7063

caaatgcata attttactgt cactttcaaa aatctgttat gactgaatca aaatcctttt     7123

aaagaaagga aaaagctcct tttgtgtcaa atagttgaac aacatgaaaa cagtatgagc     7183

cggttaaaga tagattgaat ttttacttta cacatatgaa aaacagtaag ttttgactgc     7243

tgtgtatgtt attcatgtta atatgtgctc agttattcac tattgttaat ccacatataa     7303

tcagttgcta tccctggtta gacacactat ggaacttgaa atgcacaata tttacattgt     7363

tagaggcttc tatccaaata tctgcattcc tttaaaatgt gaactatttg ctgtgattaa     7423

ccaaaggtag attatgtcat cagtggacat tttagcttta tggaaacaaa ttattaagaa     7483

atgaatagaa aggtgtcttt ttctttgtgt agtgcaaaag cctaaagcta tcagtcaaag     7543

gcctaagaaa tccacatttg aaaaacgtaa atcatgattg gtaagaatac attcatctga     7603

tagtattgag aaaagttgaa aaactgttag ccttccataa cacattaaac attttatgta     7663

tggatggctg aaagtattga gaaaagctga aaaactgtta gccttccata acacattaaa     7723

cgttttgtgt atggatggct taggacaata aacaacatca ttaaagtaaa attatgtcag     7783

tctgttcata ttaacttatt taaatcaatg aaaattttga tgagatgact aaatggatgc     7843

tttggaaatg caggattata ggaggcctaa aagtgcatct tgtttcttgt aaccctttta     7903

aaaccaatat gcctggctag gtgcagtggc tcatgcctgt aataccaacg gggtaacaca     7963

gggttatgcc gtctatacaa aaaaataaat gagctgggca agatggcatg cacctgtagt     8023

cccagctgct tggtaggctg agggggaagg attgcttgag cctgggaggt cgagactgca     8083

gtgagccaag atcacaccac tgcactccag cctgggtgac agagcaagac tctacctcaa     8143

aaataaaaat aatcaatata gtttcaatga agcaaagcat ctcaggtaac aatttgagca     8203

taactttaac cataacttat gatagcataa taacattcat tagtaattca gtagccgtat     8263

gtgccaggct gtgttaggtg ctttatatat tgtttaattt ttaaaaactt gtggagtgta     8323

cagattggta aggtgacatt gtatcacaaa gctagtcttt gagtccaaag ttttgtggtt     8383

ttatgttatg atatactttt atcatggaat tgtcttatta aatgttttgc cagtggttct     8443

taaagtgtgt ttctgacacc agtagcattg acttcactta gaaacctgtt agaaatacaa     8503

attatttggc cccacccaac acttgagtca caaactttgc agatggggct caatctgttt     8563

taacaagcgc ttcatgtaat tttgatgcag gcctaagttt ttgagccact gcagtatgca     8623

tttctatttt taagcaaaga tcttggtctt tctttttgga cattgtagaa ataacatgaa     8683

cttgtttttt gtttgttttt gttttgtttt gttttaagct cctgatcttt gttggttatg     8743

ttgcaaaaga ttgtatcagg agaagcctca gcatggacat tggcatcctg acataacccc     8803

cattaattta gtattctttc tgaaactcaa atggattctc aagtccaaga gactatggaa     8863

taaaatcatt gtttgtctgt gttaagtttt atctctgtta ttgcctgaag acttttggta     8923

acaataatgc gctttcatca aacttttaag acttgattgg aaaaaataaa tgtatgtttc     8983

atcagtta                                                              8991


<210>  41
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Thr Gly Gly Tyr Arg Thr Ser Ser Gly Leu Gly Gly Ser Thr 
1               5                   10                  15      


Thr Asp Phe Leu Glu Glu Trp Lys Ala Lys Arg Glu Lys Met Arg Ala 
            20                  25                  30          


Lys Gln Asn Pro Pro Gly Pro Ala Pro Pro Gly Gly Gly Ser Ser Asp 
        35                  40                  45              


Ala Ala Gly Lys Pro Pro Ala Gly Ala Leu Gly Thr Pro Ala Ala Ala 
    50                  55                  60                  


Ala Ala Asn Glu Leu Asn Asn Asn Leu Pro Gly Gly Ala Pro Ala Ala 
65                  70                  75                  80  


Pro Ala Val Pro Gly Pro Gly Gly Val Asn Cys Ala Val Gly Ser Ala 
                85                  90                  95      


Met Leu Thr Arg Ala Ala Pro Gly Pro Arg Arg Ser Glu Asp Glu Pro 
            100                 105                 110         


Pro Ala Ala Ser Ala Ser Ala Ala Pro Pro Pro Gln Arg Asp Glu Glu 
        115                 120                 125             


Glu Pro Asp Gly Val Pro Glu Lys Gly Lys Ser Ser Gly Pro Ser Ala 
    130                 135                 140                 


Arg Lys Gly Lys Gly Gln Ile Glu Lys Arg Lys Leu Arg Glu Lys Arg 
145                 150                 155                 160 


Arg Ser Thr Gly Val Val Asn Ile Pro Ala Ala Glu Cys Leu Asp Glu 
                165                 170                 175     


Tyr Glu Asp Asp Glu Ala Gly Gln Lys Glu Arg Lys Arg Glu Asp Ala 
            180                 185                 190         


Ile Thr Gln Gln Asn Thr Ile Gln Asn Glu Ala Val Asn Leu Leu Asp 
        195                 200                 205             


Pro Gly Ser Ser Tyr Leu Leu Gln Glu Pro Pro Arg Thr Val Ser Gly 
    210                 215                 220                 


Arg Tyr Lys Ser Thr Thr Ser Val Ser Glu Glu Asp Val Ser Ser Arg 
225                 230                 235                 240 


Tyr Ser Arg Thr Asp Arg Ser Gly Phe Pro Arg Tyr Asn Arg Asp Ala 
                245                 250                 255     


Asn Val Ser Gly Thr Leu Val Ser Ser Ser Thr Leu Glu Lys Lys Ile 
            260                 265                 270         


Glu Asp Leu Glu Lys Glu Val Val Arg Glu Arg Gln Glu Asn Leu Arg 
        275                 280                 285             


Leu Val Arg Leu Met Gln Asp Lys Glu Glu Met Ile Gly Lys Leu Lys 
    290                 295                 300                 


Glu Glu Ile Asp Leu Leu Asn Arg Asp Leu Asp Asp Ile Glu Asp Glu 
305                 310                 315                 320 


Asn Glu Gln Leu Lys Gln Glu Asn Lys Thr Leu Leu Lys Val Val Gly 
                325                 330                 335     


Gln Leu Thr Arg 
            340 


<210>  42
<211>  3971
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (185)..(2548)

<400>  42
agacctcttt cagcctaaga ggaaagcctg ttagcagagc acggaccagt gtctccggag       60

aatgctattc tcctacattt ccgaacaggt tatcaacgca cagatcgatc actgcctctg      120

tcccatcgct ccctgaagta gctctgactc cggttccttg aaaggggcgt gtacagaagt      180

aaag atg gag cct gca ggg gag cgc ttt ccc gaa caa agg caa gtc ctg       229
     Met Glu Pro Ala Gly Glu Arg Phe Pro Glu Gln Arg Gln Val Leu          
     1               5                   10                  15           

att ctc ctt ctt tta ctg gaa gtg act ctg gca ggc tgg gaa ccc cgt        277
Ile Leu Leu Leu Leu Leu Glu Val Thr Leu Ala Gly Trp Glu Pro Arg           
                20                  25                  30                

cgc tat tct gtg atg gag gaa aca gag aga ggt tct ttt gta gcc aac        325
Arg Tyr Ser Val Met Glu Glu Thr Glu Arg Gly Ser Phe Val Ala Asn           
            35                  40                  45                    

ctg gcc aat gac cta ggg ctg gga gtg ggg gag cta gcc gag cgg gga        373
Leu Ala Asn Asp Leu Gly Leu Gly Val Gly Glu Leu Ala Glu Arg Gly           
        50                  55                  60                        

gcc cgg gta gtt tct gag gat aac gaa caa ggc ttg cag ctt gat ctg        421
Ala Arg Val Val Ser Glu Asp Asn Glu Gln Gly Leu Gln Leu Asp Leu           
    65                  70                  75                            

cag acc ggg cag ttg ata tta aat gag aag ctg gac cgg gag aag ctg        469
Gln Thr Gly Gln Leu Ile Leu Asn Glu Lys Leu Asp Arg Glu Lys Leu           
80                  85                  90                  95            

tgt ggc cct act gag ccc tgt ata atg cat ttc caa gtg tta ctg aaa        517
Cys Gly Pro Thr Glu Pro Cys Ile Met His Phe Gln Val Leu Leu Lys           
                100                 105                 110               

aaa cct ttg gaa gta ttt cga gct gaa cta cta gtg aca gac ata aac        565
Lys Pro Leu Glu Val Phe Arg Ala Glu Leu Leu Val Thr Asp Ile Asn           
            115                 120                 125                   

gat cat tct cct gag ttt cct gaa aga gaa atg acc ctg aaa atc cca        613
Asp His Ser Pro Glu Phe Pro Glu Arg Glu Met Thr Leu Lys Ile Pro           
        130                 135                 140                       

gaa act agc tcc ctt ggg act gtg ttt cct ctg aaa aaa gct cgg gac        661
Glu Thr Ser Ser Leu Gly Thr Val Phe Pro Leu Lys Lys Ala Arg Asp           
    145                 150                 155                           

ttg gac gtg ggc agc aat aat gtt caa aac tac aat att tct ccc aat        709
Leu Asp Val Gly Ser Asn Asn Val Gln Asn Tyr Asn Ile Ser Pro Asn           
160                 165                 170                 175           

tct cat ttc cat gtt tcc act cgc acc cga ggg gat ggc agg aaa tac        757
Ser His Phe His Val Ser Thr Arg Thr Arg Gly Asp Gly Arg Lys Tyr           
                180                 185                 190               

cca gag ctg gtg ctg gac aca gaa ctg gat cgc gag gag cag gcc gag        805
Pro Glu Leu Val Leu Asp Thr Glu Leu Asp Arg Glu Glu Gln Ala Glu           
            195                 200                 205                   

ctc aga tta acc ttg aca gcg gtg gac ggt ggc tct cca ccc cga tct        853
Leu Arg Leu Thr Leu Thr Ala Val Asp Gly Gly Ser Pro Pro Arg Ser           
        210                 215                 220                       

ggc acc gtc cag atc ctc atc ttg gtc ttg gac gcc aat gac aat gcc        901
Gly Thr Val Gln Ile Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala           
    225                 230                 235                           

ccg gag ttt gtg cag gcg ctc tac gag gtg cag gtc cca gag aac agc        949
Pro Glu Phe Val Gln Ala Leu Tyr Glu Val Gln Val Pro Glu Asn Ser           
240                 245                 250                 255           

cca gta ggc tcc cta gtt gtc aag gtc tct gct agg gat tta gac act        997
Pro Val Gly Ser Leu Val Val Lys Val Ser Ala Arg Asp Leu Asp Thr           
                260                 265                 270               

ggg aca aat gga gag ata tca tac tcc ctt tat tac agc tct cag gag       1045
Gly Thr Asn Gly Glu Ile Ser Tyr Ser Leu Tyr Tyr Ser Ser Gln Glu           
            275                 280                 285                   

ata gac aaa cct ttt gag cta agc agc ctt tca gga gaa att cga cta       1093
Ile Asp Lys Pro Phe Glu Leu Ser Ser Leu Ser Gly Glu Ile Arg Leu           
        290                 295                 300                       

att aaa aaa cta gat ttt gag aca atg tct tcg tat gat cta gat ata       1141
Ile Lys Lys Leu Asp Phe Glu Thr Met Ser Ser Tyr Asp Leu Asp Ile           
    305                 310                 315                           

gag gca tct gat ggc ggg gga ctt tct gga aaa tgc tct gtc tct gtt       1189
Glu Ala Ser Asp Gly Gly Gly Leu Ser Gly Lys Cys Ser Val Ser Val           
320                 325                 330                 335           

aag gtg ctg gat gtt aac gat aac ttc ccg gaa cta agt att tca tca       1237
Lys Val Leu Asp Val Asn Asp Asn Phe Pro Glu Leu Ser Ile Ser Ser           
                340                 345                 350               

ctt acc agc cct att ccc gag aat tct cca gag aca gaa gtg gcc ctg       1285
Leu Thr Ser Pro Ile Pro Glu Asn Ser Pro Glu Thr Glu Val Ala Leu           
            355                 360                 365                   

ttt agg att aga gac cga gac tct ggg gaa aat gga aaa atg att tgc       1333
Phe Arg Ile Arg Asp Arg Asp Ser Gly Glu Asn Gly Lys Met Ile Cys           
        370                 375                 380                       

tca att cag gat gat gtt cct ttt aag cta aaa cct tct gtt gag aat       1381
Ser Ile Gln Asp Asp Val Pro Phe Lys Leu Lys Pro Ser Val Glu Asn           
    385                 390                 395                           

ttc tac agg ctg gta aca gaa ggg gcg ctg gac aga gag acc aga gcc       1429
Phe Tyr Arg Leu Val Thr Glu Gly Ala Leu Asp Arg Glu Thr Arg Ala           
400                 405                 410                 415           

gag tac aac atc acc atc acc atc aca gac ttg ggg act cca agg ctg       1477
Glu Tyr Asn Ile Thr Ile Thr Ile Thr Asp Leu Gly Thr Pro Arg Leu           
                420                 425                 430               

aaa acc gag cag agc ata acc gtg ctg gtg tcg gac gtc aat gac aac       1525
Lys Thr Glu Gln Ser Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn           
            435                 440                 445                   

gcc ccc gcc ttc acc caa acc tcc tac acc ctg ttc gtc cgc gag aac       1573
Ala Pro Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn           
        450                 455                 460                       

aac agc ccc gcc ctg cac atc ggc agt gtc agc gcc aca gac aga gac       1621
Asn Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp           
    465                 470                 475                           

tcg ggc acc aac gcc cag gtc acc tac tcg ctg ctg ccg ccc cgg gac       1669
Ser Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Arg Asp           
480                 485                 490                 495           

ccg cac ctg ccc ctc acc tcc ctg gtc tcc att aac acg gac aac ggc       1717
Pro His Leu Pro Leu Thr Ser Leu Val Ser Ile Asn Thr Asp Asn Gly           
                500                 505                 510               

cac ctg ttc gct ctc cag tcg ctg gac tac gag gcc ctg cag gct ttc       1765
His Leu Phe Ala Leu Gln Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe           
            515                 520                 525                   

gag ttc cgc gtg ggc gcc aca gac cgc ggc ttc ccg gcg ctg agc agc       1813
Glu Phe Arg Val Gly Ala Thr Asp Arg Gly Phe Pro Ala Leu Ser Ser           
        530                 535                 540                       

gag gcg ctg gtg cga gtg ctg gtg ctg gac gcc aac gac aac tcg ccc       1861
Glu Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro           
    545                 550                 555                           

ttc gtg ctg tac ccg ctg cag aac ggc tcc gcg ccc tgc acc gag ctg       1909
Phe Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu           
560                 565                 570                 575           

gtg ccc cgg gcg gcc gag ccg ggc tac ctg gtg acc aag gtg gtg gcg       1957
Val Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala           
                580                 585                 590               

gtg gac ggc gac tcg ggc cag aac gcc tgg ctg tcg tac cag ctg ctc       2005
Val Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu           
            595                 600                 605                   

aag gcc acg gag ccc ggg ctg ttc ggc gtg tgg gcg cac aat ggc gag       2053
Lys Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu           
        610                 615                 620                       

gtg cgc acc gcc agg ctg ctg agc gag cgc gac gtg gcc aag cac agg       2101
Val Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Val Ala Lys His Arg           
    625                 630                 635                           

cta gtg gtg ctg gtc aag gac aat ggc gag cct ccg cgc tcg gcc acc       2149
Leu Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr           
640                 645                 650                 655           

gcc acg ctg caa gtg ctc ctg gtg gac ggc ttc tct cag ccc tac ctg       2197
Ala Thr Leu Gln Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu           
                660                 665                 670               

ccg ctc cca gag gcg gcc ccg gcc caa gcc cag gcc gac tcg ctt acc       2245
Pro Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr           
            675                 680                 685                   

gtc tac ctg gtg gtg gca ttg gcc tcg gtg tct tcg ctc ttc ctc ttc       2293
Val Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe           
        690                 695                 700                       

tcg gtg ttc ctg ttc gtg gca gtg cgg ctg tgc agg agg agc agg gcg       2341
Ser Val Phe Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala           
    705                 710                 715                           

gcc tca gtg ggt cgc tgc tcg gtg ccc gag ggc ccc ttt cca ggg cat       2389
Ala Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His           
720                 725                 730                 735           

ctg gtg gac gtg agc ggc acc ggg acc ctt tcc cag agc tac cag tac       2437
Leu Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr           
                740                 745                 750               

gag gtg tgt ctg acg gga ggc tct gaa agt aat gat ttc aag ttc ttg       2485
Glu Val Cys Leu Thr Gly Gly Ser Glu Ser Asn Asp Phe Lys Phe Leu           
            755                 760                 765                   

aag cct ata ttc cca aat att gta agc cag gac tct agg agg aaa tca       2533
Lys Pro Ile Phe Pro Asn Ile Val Ser Gln Asp Ser Arg Arg Lys Ser           
        770                 775                 780                       

gaa ttt cta gaa taa tgtaggtatc tgtagctttc cgaccgtctg ttaattttgt       2588
Glu Phe Leu Glu                                                           
    785                                                                   

cttcctcact tttcacctta gtttttttta accctttagt aatcttgaat tctacttttt     2648

tttaaatttc tactgttgtc tttagtaatg ttactcattt cctttgtctg attgttagtt     2708

ttcaaattat tgtattatta taaatatttt atatcaggaa agttcatatt tctgaataaa     2768

ttaatagtat tcattcctga agggtgatat gaaagttaac cccacctaat aaacataact     2828

ctaattctga aattaccttt cacactatat gacactacat aagaatgtat gatttttgaa     2888

gtcatatttt aagttttttt tatagttttt cttattcaca cagcttgact ttttgacaaa     2948

agtttggggt gtaatcattt catatttatc catgtgtaat ttcttccaag cttcatattt     3008

ggagttttgt tttttccaat aaggagcaac atggataagt ttaagctact cttttcaagg     3068

tcacacttgt aagcattaga ttttcattct aaaacacata tgtcatctca taaaaatata     3128

tctgcgtaat gtattctgtc tcatgtaaat taacatagaa aagactaatg ggttcttcct     3188

tatctctatc taatgttatg atcctattgg ggggactgga caggctttct aatacccaga     3248

tttactgtgt ttaaggtgtt cgtataaggc caatagacac taggaccaag taatgcatct     3308

cctgcaattt cctcttttca cagcaggaaa atcttaacga gttccaaatt ctgggcttag     3368

aggagcttct gatggtacag tatgccaaca tctacttgtt ttggatggca acattgttct     3428

gattcataag gaatttgaaa gaaaatacat tgtagaatta atattagtta accaaacaaa     3488

atttattaaa ggatatgttg gtgaaggagt tgaattattt gaggaaaaaa catctgctct     3548

cttgtcagga cttttctgtc tccaggagct tctcaacttt gcagatactc tagaatggta     3608

ttgcatgcaa aataatgacc gccaagatgt tcctgcccta atccccagaa cctatgaata     3668

tgttatattg caaagaaatt aaggttcaaa cagaattaag gttgccaatc agctaaactt     3728

aaaataggga gactctccta gataatctgg gtgggtctat ttcaatcagt ggaaaggcca     3788

taaaagcaga gttgagtctt ccgtgagatg aaaataaatt ttgtttaagg acagcagctt     3848

cagcttatgc cccagaattc cagcctgccc ctcctaactg cctgctgtac agattttgga     3908

cttgtccagc cacgtttcaa aactgagtaa gtcacttcct tgcaataaat tgattactac     3968

aca                                                                   3971


<210>  43
<211>  787
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Glu Pro Ala Gly Glu Arg Phe Pro Glu Gln Arg Gln Val Leu Ile 
1               5                   10                  15      


Leu Leu Leu Leu Leu Glu Val Thr Leu Ala Gly Trp Glu Pro Arg Arg 
            20                  25                  30          


Tyr Ser Val Met Glu Glu Thr Glu Arg Gly Ser Phe Val Ala Asn Leu 
        35                  40                  45              


Ala Asn Asp Leu Gly Leu Gly Val Gly Glu Leu Ala Glu Arg Gly Ala 
    50                  55                  60                  


Arg Val Val Ser Glu Asp Asn Glu Gln Gly Leu Gln Leu Asp Leu Gln 
65                  70                  75                  80  


Thr Gly Gln Leu Ile Leu Asn Glu Lys Leu Asp Arg Glu Lys Leu Cys 
                85                  90                  95      


Gly Pro Thr Glu Pro Cys Ile Met His Phe Gln Val Leu Leu Lys Lys 
            100                 105                 110         


Pro Leu Glu Val Phe Arg Ala Glu Leu Leu Val Thr Asp Ile Asn Asp 
        115                 120                 125             


His Ser Pro Glu Phe Pro Glu Arg Glu Met Thr Leu Lys Ile Pro Glu 
    130                 135                 140                 


Thr Ser Ser Leu Gly Thr Val Phe Pro Leu Lys Lys Ala Arg Asp Leu 
145                 150                 155                 160 


Asp Val Gly Ser Asn Asn Val Gln Asn Tyr Asn Ile Ser Pro Asn Ser 
                165                 170                 175     


His Phe His Val Ser Thr Arg Thr Arg Gly Asp Gly Arg Lys Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Thr Glu Leu Asp Arg Glu Glu Gln Ala Glu Leu 
        195                 200                 205             


Arg Leu Thr Leu Thr Ala Val Asp Gly Gly Ser Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Val Gln Ile Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Val Gln Ala Leu Tyr Glu Val Gln Val Pro Glu Asn Ser Pro 
                245                 250                 255     


Val Gly Ser Leu Val Val Lys Val Ser Ala Arg Asp Leu Asp Thr Gly 
            260                 265                 270         


Thr Asn Gly Glu Ile Ser Tyr Ser Leu Tyr Tyr Ser Ser Gln Glu Ile 
        275                 280                 285             


Asp Lys Pro Phe Glu Leu Ser Ser Leu Ser Gly Glu Ile Arg Leu Ile 
    290                 295                 300                 


Lys Lys Leu Asp Phe Glu Thr Met Ser Ser Tyr Asp Leu Asp Ile Glu 
305                 310                 315                 320 


Ala Ser Asp Gly Gly Gly Leu Ser Gly Lys Cys Ser Val Ser Val Lys 
                325                 330                 335     


Val Leu Asp Val Asn Asp Asn Phe Pro Glu Leu Ser Ile Ser Ser Leu 
            340                 345                 350         


Thr Ser Pro Ile Pro Glu Asn Ser Pro Glu Thr Glu Val Ala Leu Phe 
        355                 360                 365             


Arg Ile Arg Asp Arg Asp Ser Gly Glu Asn Gly Lys Met Ile Cys Ser 
    370                 375                 380                 


Ile Gln Asp Asp Val Pro Phe Lys Leu Lys Pro Ser Val Glu Asn Phe 
385                 390                 395                 400 


Tyr Arg Leu Val Thr Glu Gly Ala Leu Asp Arg Glu Thr Arg Ala Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Ile Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Glu Gln Ser Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Arg Asp Pro 
                485                 490                 495     


His Leu Pro Leu Thr Ser Leu Val Ser Ile Asn Thr Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Gln Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp Arg Gly Phe Pro Ala Leu Ser Ser Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Val Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu Gln Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val 
        675                 680                 685             


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser 
    690                 695                 700                 


Val Phe Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
705                 710                 715                 720 


Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu 
                725                 730                 735     


Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu 
            740                 745                 750         


Val Cys Leu Thr Gly Gly Ser Glu Ser Asn Asp Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Ile Phe Pro Asn Ile Val Ser Gln Asp Ser Arg Arg Lys Ser Glu 
    770                 775                 780                 


Phe Leu Glu 
785         


<210>  44
<211>  2940
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (206)..(2455)

<400>  44
aaacatctgc aaaagcgcaa ggagaccagc ccacatttta gcccctccta ctcaggataa       60

gactttctct aagtccggag ctgaaaaagg atcctgactg aaagctagag gcattgagga      120

gcctgaagat tctcaggttt taaagacgct agagtgccaa agaagacttt gaagtgtgaa      180

aacatttcct gtaattgaaa ccaaa atg tca ttt ata gat cct tac cag cac        232
                            Met Ser Phe Ile Asp Pro Tyr Gln His           
                            1               5                             

att ata gtg gag cac cag tat tcc cac aag ttt acg gta gtg gtg tta        280
Ile Ile Val Glu His Gln Tyr Ser His Lys Phe Thr Val Val Val Leu           
10                  15                  20                  25            

cgt gcc acc aaa gtg aca aag ggg gcc ttt ggt gac atg ctt gat act        328
Arg Ala Thr Lys Val Thr Lys Gly Ala Phe Gly Asp Met Leu Asp Thr           
                30                  35                  40                

cca gat ccc tat gtg gaa ctt ttt atc tct aca acc cct gac agc agg        376
Pro Asp Pro Tyr Val Glu Leu Phe Ile Ser Thr Thr Pro Asp Ser Arg           
            45                  50                  55                    

aag aga aca aga cat ttc aat aat gac ata aac cct gtg tgg aat gag        424
Lys Arg Thr Arg His Phe Asn Asn Asp Ile Asn Pro Val Trp Asn Glu           
        60                  65                  70                        

acc ttt gaa ttt att ttg gat cct aat cag gaa aat gtt ttg gag att        472
Thr Phe Glu Phe Ile Leu Asp Pro Asn Gln Glu Asn Val Leu Glu Ile           
    75                  80                  85                            

acg tta atg gat gcc aat tat gtc atg gat gaa act cta ggg aca gca        520
Thr Leu Met Asp Ala Asn Tyr Val Met Asp Glu Thr Leu Gly Thr Ala           
90                  95                  100                 105           

aca ttt act gta tct tct atg aag gtg gga gaa aag aaa gaa gtt cct        568
Thr Phe Thr Val Ser Ser Met Lys Val Gly Glu Lys Lys Glu Val Pro           
                110                 115                 120               

ttt att ttc aac caa gtc act gaa atg gtt cta gaa atg tct ctt gaa        616
Phe Ile Phe Asn Gln Val Thr Glu Met Val Leu Glu Met Ser Leu Glu           
            125                 130                 135                   

gtt tgc tca tgc cca gac cta cga ttt agt atg gct ctg tgt gat cag        664
Val Cys Ser Cys Pro Asp Leu Arg Phe Ser Met Ala Leu Cys Asp Gln           
        140                 145                 150                       

gag aag act ttc aga caa cag aga aaa gaa cac ata agg gag agc atg        712
Glu Lys Thr Phe Arg Gln Gln Arg Lys Glu His Ile Arg Glu Ser Met           
    155                 160                 165                           

aag aaa ctc ttg ggt cca aag aat agt gaa gga ttg cat tct gca cgt        760
Lys Lys Leu Leu Gly Pro Lys Asn Ser Glu Gly Leu His Ser Ala Arg           
170                 175                 180                 185           

gat gtg cct gtg gta gcc ata ttg ggt tca ggt ggg ggt ttc cga gcc        808
Asp Val Pro Val Val Ala Ile Leu Gly Ser Gly Gly Gly Phe Arg Ala           
                190                 195                 200               

atg gtg gga ttc tct ggt gtg atg aag gca tta tac gaa tca gga att        856
Met Val Gly Phe Ser Gly Val Met Lys Ala Leu Tyr Glu Ser Gly Ile           
            205                 210                 215                   

ctg gat tgt gct acc tac gtt gct ggt ctt tct ggc tcc acc tgg tat        904
Leu Asp Cys Ala Thr Tyr Val Ala Gly Leu Ser Gly Ser Thr Trp Tyr           
        220                 225                 230                       

atg tca acc ttg tat tct cac cct gat ttt cca gag aaa ggg cca gag        952
Met Ser Thr Leu Tyr Ser His Pro Asp Phe Pro Glu Lys Gly Pro Glu           
    235                 240                 245                           

gag att aat gaa gaa cta atg aaa aat gtt agc cac aat ccc ctt tta       1000
Glu Ile Asn Glu Glu Leu Met Lys Asn Val Ser His Asn Pro Leu Leu           
250                 255                 260                 265           

ctt ctc aca cca cag aaa gtt aaa aga tat gtt gag tct tta tgg aag       1048
Leu Leu Thr Pro Gln Lys Val Lys Arg Tyr Val Glu Ser Leu Trp Lys           
                270                 275                 280               

aag aaa agc tct gga caa cct gtc acc ttt act gat atc ttt ggg atg       1096
Lys Lys Ser Ser Gly Gln Pro Val Thr Phe Thr Asp Ile Phe Gly Met           
            285                 290                 295                   

tta ata gga gaa aca cta att cat aat aga atg aat act act ctg agc       1144
Leu Ile Gly Glu Thr Leu Ile His Asn Arg Met Asn Thr Thr Leu Ser           
        300                 305                 310                       

agt ttg aag gaa aaa gtt aat act gca caa tgc cct tta cct ctt ttc       1192
Ser Leu Lys Glu Lys Val Asn Thr Ala Gln Cys Pro Leu Pro Leu Phe           
    315                 320                 325                           

acc tgt ctt cat gtc aaa cct gac gtt tca gag ctg atg ttt gca gat       1240
Thr Cys Leu His Val Lys Pro Asp Val Ser Glu Leu Met Phe Ala Asp           
330                 335                 340                 345           

tgg gtt gaa ttt agt cca tac gaa att ggc atg gct aaa tat ggt act       1288
Trp Val Glu Phe Ser Pro Tyr Glu Ile Gly Met Ala Lys Tyr Gly Thr           
                350                 355                 360               

ttt atg gct ccc gac tta ttt gga agc aaa ttt ttt atg gga aca gtc       1336
Phe Met Ala Pro Asp Leu Phe Gly Ser Lys Phe Phe Met Gly Thr Val           
            365                 370                 375                   

gtt aag aag tat gaa gaa aac ccc ttg cat ttc tta atg ggt gtc tgg       1384
Val Lys Lys Tyr Glu Glu Asn Pro Leu His Phe Leu Met Gly Val Trp           
        380                 385                 390                       

ggc agt gcc ttt tcc ata ttg ttc aac aga gtt ttg ggc gtt tct ggt       1432
Gly Ser Ala Phe Ser Ile Leu Phe Asn Arg Val Leu Gly Val Ser Gly           
    395                 400                 405                           

tca caa agc aga ggc tcc aca atg gag gaa gaa tta gaa aat att acc       1480
Ser Gln Ser Arg Gly Ser Thr Met Glu Glu Glu Leu Glu Asn Ile Thr           
410                 415                 420                 425           

aca aag cat att gtg agt aat gat agc tcg gac agt gat gat gaa tca       1528
Thr Lys His Ile Val Ser Asn Asp Ser Ser Asp Ser Asp Asp Glu Ser           
                430                 435                 440               

cac gaa ccc aaa ggc act gaa aat gaa gat gct gga agt gac tat caa       1576
His Glu Pro Lys Gly Thr Glu Asn Glu Asp Ala Gly Ser Asp Tyr Gln           
            445                 450                 455                   

agt gat aat caa gca agt tgg att cat cgt atg ata atg gcc ttg gtg       1624
Ser Asp Asn Gln Ala Ser Trp Ile His Arg Met Ile Met Ala Leu Val           
        460                 465                 470                       

agt gat tca gct tta ttc aat acc aga gaa gga cgt gct ggg aag gta       1672
Ser Asp Ser Ala Leu Phe Asn Thr Arg Glu Gly Arg Ala Gly Lys Val           
    475                 480                 485                           

cac aac ttc atg ctg ggc ttg aat ctc aat aca tct tat cca ctg tct       1720
His Asn Phe Met Leu Gly Leu Asn Leu Asn Thr Ser Tyr Pro Leu Ser           
490                 495                 500                 505           

cct ttg agt gac ttt gcc aca cag gac tcc ttt gat gat gat gaa ctg       1768
Pro Leu Ser Asp Phe Ala Thr Gln Asp Ser Phe Asp Asp Asp Glu Leu           
                510                 515                 520               

gat gca gct gta gca gat cct gat gaa ttt gag cga ata tat gag cct       1816
Asp Ala Ala Val Ala Asp Pro Asp Glu Phe Glu Arg Ile Tyr Glu Pro           
            525                 530                 535                   

ctg gat gtc aaa agt aaa aag att cat gta gtg gac agt ggg ctc aca       1864
Leu Asp Val Lys Ser Lys Lys Ile His Val Val Asp Ser Gly Leu Thr           
        540                 545                 550                       

ttt aac ctg ccg tat ccc ttg ata ctg aga cct cag aga ggg gtt gat       1912
Phe Asn Leu Pro Tyr Pro Leu Ile Leu Arg Pro Gln Arg Gly Val Asp           
    555                 560                 565                           

ctc ata atc tcc ttt gac ttt tct gca agg cca agt gac tct agt cct       1960
Leu Ile Ile Ser Phe Asp Phe Ser Ala Arg Pro Ser Asp Ser Ser Pro           
570                 575                 580                 585           

ccg ttc aag gaa ctt cta ctt gca gaa aag tgg gct aaa atg aac aag       2008
Pro Phe Lys Glu Leu Leu Leu Ala Glu Lys Trp Ala Lys Met Asn Lys           
                590                 595                 600               

ctc ccc ttt cca aag att gat cct tat gtg ttt gat cgg gaa ggg ctg       2056
Leu Pro Phe Pro Lys Ile Asp Pro Tyr Val Phe Asp Arg Glu Gly Leu           
            605                 610                 615                   

aag gag tgc tat gtc ttt aaa ccc aag aat cct gat atg gag aaa gat       2104
Lys Glu Cys Tyr Val Phe Lys Pro Lys Asn Pro Asp Met Glu Lys Asp           
        620                 625                 630                       

tgc cca acc atc atc cac ttt gtt ctg gcc aac atc aac ttc aga aag       2152
Cys Pro Thr Ile Ile His Phe Val Leu Ala Asn Ile Asn Phe Arg Lys           
    635                 640                 645                           

tac aag gct cca ggt gtt cca agg gaa act gag gaa gag aaa gaa atc       2200
Tyr Lys Ala Pro Gly Val Pro Arg Glu Thr Glu Glu Glu Lys Glu Ile           
650                 655                 660                 665           

gct gac ttt gat att ttt gat gac cca gaa tca cca ttt tca acc ttc       2248
Ala Asp Phe Asp Ile Phe Asp Asp Pro Glu Ser Pro Phe Ser Thr Phe           
                670                 675                 680               

aat ttt caa tat cca aat caa gca ttc aaa aga cta cat gat ctt atg       2296
Asn Phe Gln Tyr Pro Asn Gln Ala Phe Lys Arg Leu His Asp Leu Met           
            685                 690                 695                   

cac ttc aat act ctg aac aac att gat gtg ata aaa gaa gcc atg gtt       2344
His Phe Asn Thr Leu Asn Asn Ile Asp Val Ile Lys Glu Ala Met Val           
        700                 705                 710                       

gaa agc att gaa tat aga aga cag aat cca tct cgt tgc tct gtt tcc       2392
Glu Ser Ile Glu Tyr Arg Arg Gln Asn Pro Ser Arg Cys Ser Val Ser           
    715                 720                 725                           

ctt agt aat gtt gag gca aga aga ttt ttc aac aag gag ttt cta agt       2440
Leu Ser Asn Val Glu Ala Arg Arg Phe Phe Asn Lys Glu Phe Leu Ser           
730                 735                 740                 745           

aaa ccc aaa gca tag ttcatgtact ggaaatggca gcagtttctg atgctgaggc       2495
Lys Pro Lys Ala                                                           
                                                                          

agtttgcaat cccatgacaa ctggatttaa aagtacagta cagatagtcg tactgatcat     2555

gagagactgg ctgatactca aagttgcagt tacttagctg catgagaata atactattat     2615

aagttaggtt gacaaatgat gttgattatg taaggatata cttagctaca ttttcagtca     2675

gtatgaactt cctgatacaa atgtagggat atatactgta tttttaaaca tttctcacca     2735

actttcttat gtgtgttctt tttaaaaatt ttttttcttt taaaatattt aacagttcaa     2795

tctcaataag acctcgcatt atgtatgaat gttattcact gactagattt attcatacca     2855

tgagacaaca ctatttttat ttatatatgc atatatatac atacatgaaa taaatacatc     2915

aatataaaaa taaaaaaaaa aaaaa                                           2940


<210>  45
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ser Phe Ile Asp Pro Tyr Gln His Ile Ile Val Glu His Gln Tyr 
1               5                   10                  15      


Ser His Lys Phe Thr Val Val Val Leu Arg Ala Thr Lys Val Thr Lys 
            20                  25                  30          


Gly Ala Phe Gly Asp Met Leu Asp Thr Pro Asp Pro Tyr Val Glu Leu 
        35                  40                  45              


Phe Ile Ser Thr Thr Pro Asp Ser Arg Lys Arg Thr Arg His Phe Asn 
    50                  55                  60                  


Asn Asp Ile Asn Pro Val Trp Asn Glu Thr Phe Glu Phe Ile Leu Asp 
65                  70                  75                  80  


Pro Asn Gln Glu Asn Val Leu Glu Ile Thr Leu Met Asp Ala Asn Tyr 
                85                  90                  95      


Val Met Asp Glu Thr Leu Gly Thr Ala Thr Phe Thr Val Ser Ser Met 
            100                 105                 110         


Lys Val Gly Glu Lys Lys Glu Val Pro Phe Ile Phe Asn Gln Val Thr 
        115                 120                 125             


Glu Met Val Leu Glu Met Ser Leu Glu Val Cys Ser Cys Pro Asp Leu 
    130                 135                 140                 


Arg Phe Ser Met Ala Leu Cys Asp Gln Glu Lys Thr Phe Arg Gln Gln 
145                 150                 155                 160 


Arg Lys Glu His Ile Arg Glu Ser Met Lys Lys Leu Leu Gly Pro Lys 
                165                 170                 175     


Asn Ser Glu Gly Leu His Ser Ala Arg Asp Val Pro Val Val Ala Ile 
            180                 185                 190         


Leu Gly Ser Gly Gly Gly Phe Arg Ala Met Val Gly Phe Ser Gly Val 
        195                 200                 205             


Met Lys Ala Leu Tyr Glu Ser Gly Ile Leu Asp Cys Ala Thr Tyr Val 
    210                 215                 220                 


Ala Gly Leu Ser Gly Ser Thr Trp Tyr Met Ser Thr Leu Tyr Ser His 
225                 230                 235                 240 


Pro Asp Phe Pro Glu Lys Gly Pro Glu Glu Ile Asn Glu Glu Leu Met 
                245                 250                 255     


Lys Asn Val Ser His Asn Pro Leu Leu Leu Leu Thr Pro Gln Lys Val 
            260                 265                 270         


Lys Arg Tyr Val Glu Ser Leu Trp Lys Lys Lys Ser Ser Gly Gln Pro 
        275                 280                 285             


Val Thr Phe Thr Asp Ile Phe Gly Met Leu Ile Gly Glu Thr Leu Ile 
    290                 295                 300                 


His Asn Arg Met Asn Thr Thr Leu Ser Ser Leu Lys Glu Lys Val Asn 
305                 310                 315                 320 


Thr Ala Gln Cys Pro Leu Pro Leu Phe Thr Cys Leu His Val Lys Pro 
                325                 330                 335     


Asp Val Ser Glu Leu Met Phe Ala Asp Trp Val Glu Phe Ser Pro Tyr 
            340                 345                 350         


Glu Ile Gly Met Ala Lys Tyr Gly Thr Phe Met Ala Pro Asp Leu Phe 
        355                 360                 365             


Gly Ser Lys Phe Phe Met Gly Thr Val Val Lys Lys Tyr Glu Glu Asn 
    370                 375                 380                 


Pro Leu His Phe Leu Met Gly Val Trp Gly Ser Ala Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Asn Arg Val Leu Gly Val Ser Gly Ser Gln Ser Arg Gly Ser Thr 
                405                 410                 415     


Met Glu Glu Glu Leu Glu Asn Ile Thr Thr Lys His Ile Val Ser Asn 
            420                 425                 430         


Asp Ser Ser Asp Ser Asp Asp Glu Ser His Glu Pro Lys Gly Thr Glu 
        435                 440                 445             


Asn Glu Asp Ala Gly Ser Asp Tyr Gln Ser Asp Asn Gln Ala Ser Trp 
    450                 455                 460                 


Ile His Arg Met Ile Met Ala Leu Val Ser Asp Ser Ala Leu Phe Asn 
465                 470                 475                 480 


Thr Arg Glu Gly Arg Ala Gly Lys Val His Asn Phe Met Leu Gly Leu 
                485                 490                 495     


Asn Leu Asn Thr Ser Tyr Pro Leu Ser Pro Leu Ser Asp Phe Ala Thr 
            500                 505                 510         


Gln Asp Ser Phe Asp Asp Asp Glu Leu Asp Ala Ala Val Ala Asp Pro 
        515                 520                 525             


Asp Glu Phe Glu Arg Ile Tyr Glu Pro Leu Asp Val Lys Ser Lys Lys 
    530                 535                 540                 


Ile His Val Val Asp Ser Gly Leu Thr Phe Asn Leu Pro Tyr Pro Leu 
545                 550                 555                 560 


Ile Leu Arg Pro Gln Arg Gly Val Asp Leu Ile Ile Ser Phe Asp Phe 
                565                 570                 575     


Ser Ala Arg Pro Ser Asp Ser Ser Pro Pro Phe Lys Glu Leu Leu Leu 
            580                 585                 590         


Ala Glu Lys Trp Ala Lys Met Asn Lys Leu Pro Phe Pro Lys Ile Asp 
        595                 600                 605             


Pro Tyr Val Phe Asp Arg Glu Gly Leu Lys Glu Cys Tyr Val Phe Lys 
    610                 615                 620                 


Pro Lys Asn Pro Asp Met Glu Lys Asp Cys Pro Thr Ile Ile His Phe 
625                 630                 635                 640 


Val Leu Ala Asn Ile Asn Phe Arg Lys Tyr Lys Ala Pro Gly Val Pro 
                645                 650                 655     


Arg Glu Thr Glu Glu Glu Lys Glu Ile Ala Asp Phe Asp Ile Phe Asp 
            660                 665                 670         


Asp Pro Glu Ser Pro Phe Ser Thr Phe Asn Phe Gln Tyr Pro Asn Gln 
        675                 680                 685             


Ala Phe Lys Arg Leu His Asp Leu Met His Phe Asn Thr Leu Asn Asn 
    690                 695                 700                 


Ile Asp Val Ile Lys Glu Ala Met Val Glu Ser Ile Glu Tyr Arg Arg 
705                 710                 715                 720 


Gln Asn Pro Ser Arg Cys Ser Val Ser Leu Ser Asn Val Glu Ala Arg 
                725                 730                 735     


Arg Phe Phe Asn Lys Glu Phe Leu Ser Lys Pro Lys Ala 
            740                 745                 


<210>  46
<211>  6696
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (508)..(3795)

<400>  46
agagctgagt ggaggccgcc gccgccgccg cacttcctgg gaccgctgcg ccgcagtccg       60

cgggcaggtg gcgggtgcgc ccggccgcag tcgcccggct ctggccccta tcgggccgcc      120

ggcgtccggg ctccagaggc cgcctggctg ggcgcccggt gccttttgtc tggcgcaggg      180

ccggcgtttg catcacattt cggatacctc cctctctttt tcgcctctcc ttctgcctcc      240

cgctcacatc gcctccccac tcccgccacc gtcccccgcc ggactgctag cctcctagac      300

cgaagcccga ggacgtctct gcccgagcga tgtcccctct ccagaaagtt gccgccgccg      360

ccgccgccgc cgccactgcc gccgctgggc ggtgaaacaa agtctggcgg ggccgcctcc      420

cggtgcagga gcgcaccggt gcctagcggc tggactccgc tgccgggcgt cccgctttcc      480

cccggggagc cctaaacgct ccaggcc atg gcc gag ggc gcg gcc ggc agg gag      534
                              Met Ala Glu Gly Ala Ala Gly Arg Glu         
                              1               5                           

gat ccg gcg ccg ccc gac gcg gcg ggg ggc gaa gac gac ccc cga gtg        582
Asp Pro Ala Pro Pro Asp Ala Ala Gly Gly Glu Asp Asp Pro Arg Val           
10                  15                  20                  25            

ggc ccg gat gcc gcc ggg gac tgc gtg acg gcg gcc tct ggg ggc cgg        630
Gly Pro Asp Ala Ala Gly Asp Cys Val Thr Ala Ala Ser Gly Gly Arg           
                30                  35                  40                

atg agg gac cgt cgc agc ggg gtc gca ctg cca ggc gcc gcg ggg acc        678
Met Arg Asp Arg Arg Ser Gly Val Ala Leu Pro Gly Ala Ala Gly Thr           
            45                  50                  55                    

cca gcg gac agc gag gcg ggc ctc ctg gag gca gca cgg gcg acc ccc        726
Pro Ala Asp Ser Glu Ala Gly Leu Leu Glu Ala Ala Arg Ala Thr Pro           
        60                  65                  70                        

cgg cgc agc agc atc atc aag gat cct tca aac caa aaa tgt ggt gga        774
Arg Arg Ser Ser Ile Ile Lys Asp Pro Ser Asn Gln Lys Cys Gly Gly           
    75                  80                  85                            

aga aag aaa acc gtg tct ttc agc agc atg cca tcg gaa aag aaa att        822
Arg Lys Lys Thr Val Ser Phe Ser Ser Met Pro Ser Glu Lys Lys Ile           
90                  95                  100                 105           

agc agt gca aat gac tgc atc agc ttc atg caa gct ggc tgt gag ttg        870
Ser Ser Ala Asn Asp Cys Ile Ser Phe Met Gln Ala Gly Cys Glu Leu           
                110                 115                 120               

aag aaa gtc cgg cca aat tct cgc att tac aac cgt ttt ttc act ctg        918
Lys Lys Val Arg Pro Asn Ser Arg Ile Tyr Asn Arg Phe Phe Thr Leu           
            125                 130                 135                   

gac aca gac ctt caa gct ctt cgc tgg gaa cct tca aag aaa gac ctc        966
Asp Thr Asp Leu Gln Ala Leu Arg Trp Glu Pro Ser Lys Lys Asp Leu           
        140                 145                 150                       

gag aaa gcc aag ctt gat att tct gcc ata aaa gag atc aga ctg ggg       1014
Glu Lys Ala Lys Leu Asp Ile Ser Ala Ile Lys Glu Ile Arg Leu Gly           
    155                 160                 165                           

aaa aac acg gaa aca ttt aga aac aat ggc ctt gct gac cag atc tgt       1062
Lys Asn Thr Glu Thr Phe Arg Asn Asn Gly Leu Ala Asp Gln Ile Cys           
170                 175                 180                 185           

gag gac tgt gcc ttt tcc ata ctc cac ggg gaa aac tat gag tct ctg       1110
Glu Asp Cys Ala Phe Ser Ile Leu His Gly Glu Asn Tyr Glu Ser Leu           
                190                 195                 200               

gac cta gtt gcc aat tca gca gat gtg gca aac atc tgg gtg tct ggg       1158
Asp Leu Val Ala Asn Ser Ala Asp Val Ala Asn Ile Trp Val Ser Gly           
            205                 210                 215                   

tta cgg tac ctg gtt tct cga agt aag cag cct ctt gat ttt atg gag       1206
Leu Arg Tyr Leu Val Ser Arg Ser Lys Gln Pro Leu Asp Phe Met Glu           
        220                 225                 230                       

ggc aac cag aac aca cca cgg ttc atg tgg ttg aaa aca gtg ttt gaa       1254
Gly Asn Gln Asn Thr Pro Arg Phe Met Trp Leu Lys Thr Val Phe Glu           
    235                 240                 245                           

gca gca gat gtt gat ggg aat ggg att atg ttg gaa gac acc tct gta       1302
Ala Ala Asp Val Asp Gly Asn Gly Ile Met Leu Glu Asp Thr Ser Val           
250                 255                 260                 265           

gag tta ata aaa caa ctc aac cct act ctg aag gaa gcc aag atc agg       1350
Glu Leu Ile Lys Gln Leu Asn Pro Thr Leu Lys Glu Ala Lys Ile Arg           
                270                 275                 280               

tta aag ttt aaa gaa atc cag aag agc aag gaa aaa cta acc acc cgc       1398
Leu Lys Phe Lys Glu Ile Gln Lys Ser Lys Glu Lys Leu Thr Thr Arg           
            285                 290                 295                   

gtg acc gaa gag gaa ttt tgt gaa gct ttt tgt gaa ctt tgc acc agg       1446
Val Thr Glu Glu Glu Phe Cys Glu Ala Phe Cys Glu Leu Cys Thr Arg           
        300                 305                 310                       

cca gaa gtg tat ttc tta ctt gta cag ata tct aaa aac aaa gaa tat       1494
Pro Glu Val Tyr Phe Leu Leu Val Gln Ile Ser Lys Asn Lys Glu Tyr           
    315                 320                 325                           

ttg gat gcc aat gat ctc atg ctc ttt tta gaa gct gag caa gga gtc       1542
Leu Asp Ala Asn Asp Leu Met Leu Phe Leu Glu Ala Glu Gln Gly Val           
330                 335                 340                 345           

acc cat atc acc gag gat ata tgc tta gac atc ata agg aga tac gaa       1590
Thr His Ile Thr Glu Asp Ile Cys Leu Asp Ile Ile Arg Arg Tyr Glu           
                350                 355                 360               

ctt tct gaa gag gga cgt caa aaa ggg ttt ctt gca att gat ggc ttt       1638
Leu Ser Glu Glu Gly Arg Gln Lys Gly Phe Leu Ala Ile Asp Gly Phe           
            365                 370                 375                   

acc cag tat tta ttg tca tca gaa tgt gac att ttt gat cct gag caa       1686
Thr Gln Tyr Leu Leu Ser Ser Glu Cys Asp Ile Phe Asp Pro Glu Gln           
        380                 385                 390                       

aag aag gtt gcc caa gat atg acc cag cca tta tct cac tac tat atc       1734
Lys Lys Val Ala Gln Asp Met Thr Gln Pro Leu Ser His Tyr Tyr Ile           
    395                 400                 405                           

aat gcc tct cat aac acc tat cta ata gaa gac cag ttc agg ggg cca       1782
Asn Ala Ser His Asn Thr Tyr Leu Ile Glu Asp Gln Phe Arg Gly Pro           
410                 415                 420                 425           

gct gac atc aat ggg tac att aga gct ttg aaa atg ggc tgt cga agc       1830
Ala Asp Ile Asn Gly Tyr Ile Arg Ala Leu Lys Met Gly Cys Arg Ser           
                430                 435                 440               

gtt gaa ctc gat gta agt gat ggt tca gat aat gaa cca atc ctt tgt       1878
Val Glu Leu Asp Val Ser Asp Gly Ser Asp Asn Glu Pro Ile Leu Cys           
            445                 450                 455                   

aat cga aat aac atg aca acc cat gtt tcc ttt cga agt gtc ata gag       1926
Asn Arg Asn Asn Met Thr Thr His Val Ser Phe Arg Ser Val Ile Glu           
        460                 465                 470                       

gta ata aat aaa ttt gcc ttt gtt gct tct gaa tac cca ctc att ctt       1974
Val Ile Asn Lys Phe Ala Phe Val Ala Ser Glu Tyr Pro Leu Ile Leu           
    475                 480                 485                           

tgc ttg gga aat cac tgc tcc ttg ccg cag cag aag gta atg gct caa       2022
Cys Leu Gly Asn His Cys Ser Leu Pro Gln Gln Lys Val Met Ala Gln           
490                 495                 500                 505           

cag atg aaa aag gtc ttt ggc aat aaa ctc tat act gaa gca cct ttg       2070
Gln Met Lys Lys Val Phe Gly Asn Lys Leu Tyr Thr Glu Ala Pro Leu           
                510                 515                 520               

ccc tca gaa tcc tac ctc cca tca cca gaa aaa tta aaa aga atg atc       2118
Pro Ser Glu Ser Tyr Leu Pro Ser Pro Glu Lys Leu Lys Arg Met Ile           
            525                 530                 535                   

att gtg aaa gga aag aag ttg cct tct gat cca gat gtg tta gaa gga       2166
Ile Val Lys Gly Lys Lys Leu Pro Ser Asp Pro Asp Val Leu Glu Gly           
        540                 545                 550                       

gaa gta aca gat gaa gat gaa gaa gct gaa atg tct cga agg atg tcg       2214
Glu Val Thr Asp Glu Asp Glu Glu Ala Glu Met Ser Arg Arg Met Ser           
    555                 560                 565                           

gta gat tac aat ggt gag cag aag caa atc cga ctc tgt agg gag ctc       2262
Val Asp Tyr Asn Gly Glu Gln Lys Gln Ile Arg Leu Cys Arg Glu Leu           
570                 575                 580                 585           

tct gat ttg gtg tct att tgt aaa tct gtt caa tac agg gat ttt gaa       2310
Ser Asp Leu Val Ser Ile Cys Lys Ser Val Gln Tyr Arg Asp Phe Glu           
                590                 595                 600               

cta tct atg aaa agc caa aac tat tgg gaa atg tgt tca ttt agt gaa       2358
Leu Ser Met Lys Ser Gln Asn Tyr Trp Glu Met Cys Ser Phe Ser Glu           
            605                 610                 615                   

aca gag gcc agc cgc att gca aat gag tac cca gag gat ttt gtt aat       2406
Thr Glu Ala Ser Arg Ile Ala Asn Glu Tyr Pro Glu Asp Phe Val Asn           
        620                 625                 630                       

tat aat aag aag ttc tta tca aga atc tat cca agt gcc atg agg atc       2454
Tyr Asn Lys Lys Phe Leu Ser Arg Ile Tyr Pro Ser Ala Met Arg Ile           
    635                 640                 645                           

gat tcc agt aac ttg aat cca cag gac ttt tgg aat tgt ggc tgt cag       2502
Asp Ser Ser Asn Leu Asn Pro Gln Asp Phe Trp Asn Cys Gly Cys Gln           
650                 655                 660                 665           

att gta gca atg aat ttt cag act ccg ggt cca atg atg gac ctt cac       2550
Ile Val Ala Met Asn Phe Gln Thr Pro Gly Pro Met Met Asp Leu His           
                670                 675                 680               

acg ggc tgg ttt ctt caa aac ggg gga tgt ggt tat gtt cta agg ccg       2598
Thr Gly Trp Phe Leu Gln Asn Gly Gly Cys Gly Tyr Val Leu Arg Pro           
            685                 690                 695                   

tct ata atg cga gat gaa gtt tct tac ttc agc gca aat aca aag ggc       2646
Ser Ile Met Arg Asp Glu Val Ser Tyr Phe Ser Ala Asn Thr Lys Gly           
        700                 705                 710                       

att cta cct ggg gtg tct cct cta gct ctt cat atc aag atc atc agt       2694
Ile Leu Pro Gly Val Ser Pro Leu Ala Leu His Ile Lys Ile Ile Ser           
    715                 720                 725                           

ggt cag aat ttc cca aag ccc aag gga gct tgt gcc aaa ggg gat gtc       2742
Gly Gln Asn Phe Pro Lys Pro Lys Gly Ala Cys Ala Lys Gly Asp Val           
730                 735                 740                 745           

ata gat ccc tat gtt tgt ata gag ata cac gga att cca gcg gat tgt       2790
Ile Asp Pro Tyr Val Cys Ile Glu Ile His Gly Ile Pro Ala Asp Cys           
                750                 755                 760               

tcg gaa caa aga act aaa act gta cag caa aac agt gat aat cct att       2838
Ser Glu Gln Arg Thr Lys Thr Val Gln Gln Asn Ser Asp Asn Pro Ile           
            765                 770                 775                   

ttt gat gaa act ttt gag ttc caa gta aac cta cct gag ctg gcc atg       2886
Phe Asp Glu Thr Phe Glu Phe Gln Val Asn Leu Pro Glu Leu Ala Met           
        780                 785                 790                       

atc cgt ttt gtt gtt ctg gat gat gac tac att ggg gat gag ttt ata       2934
Ile Arg Phe Val Val Leu Asp Asp Asp Tyr Ile Gly Asp Glu Phe Ile           
    795                 800                 805                           

ggg caa tat acg ata cca ttt gaa tgt ttg cag cct gga tat cgg cat       2982
Gly Gln Tyr Thr Ile Pro Phe Glu Cys Leu Gln Pro Gly Tyr Arg His           
810                 815                 820                 825           

gtt ccc ctg cgt tct ttt gtg ggt gac atc atg gag cac gta acc ctt       3030
Val Pro Leu Arg Ser Phe Val Gly Asp Ile Met Glu His Val Thr Leu           
                830                 835                 840               

ttt gtc cac ata gca ata act aat cga agt gga gga gga aag gca cag       3078
Phe Val His Ile Ala Ile Thr Asn Arg Ser Gly Gly Gly Lys Ala Gln           
            845                 850                 855                   

aag cgc agt ctt tca gtg aga atg ggg aag aaa gtt cgg gaa tat acc       3126
Lys Arg Ser Leu Ser Val Arg Met Gly Lys Lys Val Arg Glu Tyr Thr           
        860                 865                 870                       

atg ctc agg aat atc ggt ctt aaa acc att gat gac atc ttt aaa ata       3174
Met Leu Arg Asn Ile Gly Leu Lys Thr Ile Asp Asp Ile Phe Lys Ile           
    875                 880                 885                           

gcg gtt cat cca tta cga gaa gcc ata gat atg aga gaa aat atg cag       3222
Ala Val His Pro Leu Arg Glu Ala Ile Asp Met Arg Glu Asn Met Gln           
890                 895                 900                 905           

aat gca atc gtg tct att aag gaa cta tgt gga ctc cct cca att gcc       3270
Asn Ala Ile Val Ser Ile Lys Glu Leu Cys Gly Leu Pro Pro Ile Ala           
                910                 915                 920               

agt ctg aag cag tgc ctg tta act ctg tca tct cgg ctc atc acc agt       3318
Ser Leu Lys Gln Cys Leu Leu Thr Leu Ser Ser Arg Leu Ile Thr Ser           
            925                 930                 935                   

gac aat act cct tca gtc tca ctt gtg atg aaa gac agc ttt cct tac       3366
Asp Asn Thr Pro Ser Val Ser Leu Val Met Lys Asp Ser Phe Pro Tyr           
        940                 945                 950                       

ctg gag cct ctg ggt gca att cca gat gtg cag aaa aag atg ctg act       3414
Leu Glu Pro Leu Gly Ala Ile Pro Asp Val Gln Lys Lys Met Leu Thr           
    955                 960                 965                           

gct tat gat ctg atg att caa gag agc cgg ttt ctc ata gaa atg gcg       3462
Ala Tyr Asp Leu Met Ile Gln Glu Ser Arg Phe Leu Ile Glu Met Ala           
970                 975                 980                 985           

gac aca gtc cag gaa aag att gta cag tgt cag aaa gca ggg atg  gag      3510
Asp Thr Val Gln Glu Lys Ile Val Gln Cys Gln Lys Ala Gly Met  Glu          
                990                 995                 1000              

ttc cat gaa gaa  ctt cat aat ttg ggg  gca aaa gaa ggc ttg  aag        3555
Phe His Glu Glu  Leu His Asn Leu Gly  Ala Lys Glu Gly Leu  Lys            
            1005                 1010                 1015                

gga aga aaa ctc  aac aaa gca act gag  agc ttt gct tgg aac  att        3600
Gly Arg Lys Leu  Asn Lys Ala Thr Glu  Ser Phe Ala Trp Asn  Ile            
            1020                 1025                 1030                

aca gta ttg aag  ggc caa gga gat ctg  ttg aag aat gcc aag  aat        3645
Thr Val Leu Lys  Gly Gln Gly Asp Leu  Leu Lys Asn Ala Lys  Asn            
            1035                 1040                 1045                

gaa gct ata gaa  aac atg aag cag atc  cag ctg gca tgc ctg  tcc        3690
Glu Ala Ile Glu  Asn Met Lys Gln Ile  Gln Leu Ala Cys Leu  Ser            
            1050                 1055                 1060                

tgt gga ctg agt  aaa gcc ccc agc agc  agt gct gag gcc aag  agc        3735
Cys Gly Leu Ser  Lys Ala Pro Ser Ser  Ser Ala Glu Ala Lys  Ser            
            1065                 1070                 1075                

aag cgc agc ctg  gaa gcc ata gag gag  aag gaa agt agt gag  gag        3780
Lys Arg Ser Leu  Glu Ala Ile Glu Glu  Lys Glu Ser Ser Glu  Glu            
            1080                 1085                 1090                

aat ggg aag ctg  tga ctctgggcat tatcgacacg ttcacccatc ttatcaagga      3835
Asn Gly Lys Leu                                                           
            1095                                                          

ctctggtttc tcattcttgt tttctttctt taaatgtttt ataagttcac aaaatggtgc     3895

cctatatggg gtattggaca tagatatttt cacaatgtca gtatttcagt gtagttaatt     3955

tatctaaatt aaagccttta gtatcagtgt tttaaattct gagacatgtg tcaacacccc     4015

tgtgtggatg cctgtggaag agtgtgtgtg tgtgtgtgtg tgtgtgtgtg tggcagagag     4075

agagaaagag agagagagag agaaattctg ttaaaatcta ttctgtgttg cattattcat     4135

ttagtgagtt attccttgat cattttggga caattgtttt aatctgaaat tctaaagagc     4195

acttactgta acctgttgct gtgtttaatt tgacttctct gcctttgaca tttaatttag     4255

tgatcttagc atagcttatt attgaaggaa gccaaattta tcaaagcata gatgttttgg     4315

tagattaaat atagattaga aaaattccta agaatcagag tagaaataaa agtgaatgaa     4375

agattaaaca gatgatgaga atttctaaaa agattagcaa ggtcatttct tcagtcagaa     4435

aactttaaaa aatatttatt aaataaaatc aatttttagg aagttttctg tagtcattta     4495

ctaaacatat gatttcacta gaaaagctga tcataagtga atttatacct acctgtgtgg     4555

tactctgaaa cacactgaaa gctctgttgc aattaggatt ttgatgtgac aataatattg     4615

ttgtataatt tcgagatttg taggaaggtc tcattcttcc aagctgagag tctagcactc     4675

attttctata acagatatgg cagcttagag gtgttggctt tgtttggatg taatttaggg     4735

tactaaattt aaatttaaag atattgttca aacaatatca tatcatcaca ttgagctgat     4795

ataaattctg tgggtccgat aatatctttg tgataattta agagctaacc agttaccaca     4855

catctatgat ataaccctaa cacacacaga aaagcataca tgcaaaaaga aatgactaat     4915

tagggtacat ttataattgc atctaggtaa tttttaccct aatgtcttca taaagtactt     4975

gagtgtaatg tttgttacct ccaacagaac taaatgttct atggttatga aagaatatat     5035

ttatttaaag cattgctttt attttgaaaa gcttcttaat taatttgatt aacaaatatg     5095

ctaatttggg gaaacctaga gaagataatt gttgaaattt tgcaaatata aacatctcct     5155

atagcttctg tgttatttct gacttcttaa cactattatg tttatgttgc acattactga     5215

aagagtaaag atatgaaaaa aacacttatt gttttctttt attgtgaatt gaaaaagcaa     5275

agctaatgaa aatgggttac tacatcaaaa atatcttaaa gagtttgcta tttccatgga     5335

ccagatatga tgaaattatt ccctgggttt aaaactgggc actcgaggag gaggtacctg     5395

aagtcatttg aaggcaagtt tccaatgatg ctacaatggc ctgaaaaaat ttctttaccc     5455

tctgttatat ttaacttgct ggtaggagga atagtggaat gcaggtgtta agccctttgt     5515

ggtgaaaaag aggttctata gacagaaaca aaacccacct tacatcagct gattggttga     5575

ttttactagt gtacctcttc atctacttga attctatttg gtaaatccat gtctttactg     5635

gatatacagt taggtgggaa gaggagataa aggatgacaa actctcaaac aatatttata     5695

catttattta ctccagggtc aaatccaatc cttggaagta gcttctctag tttattttat     5755

ttgtcccaga gctctactca cacttaggac ccacccaaaa attctcaaaa acgtaatatg     5815

gattctgcct catctgatgc tatttctggc agtgggttgt cagccatact ctgcttcatt     5875

ccactgggtg tccttgctag atggggagtg agatgtggag cagggaggag ctttggattc     5935

tgggagtgga ggtggcaagg gaaaagtctc ctagtctcct gtgatgttcc tgcctccaga     5995

tagaatagca aaaacaaaca attttttttt gtgtattatg cctccatgac attgttacat     6055

tctatgagga gcatctgtct cctttctaga cttgaactgt ggtagaaaaa gcccccttct     6115

ctcttctatc tacttagatt tggtgatgct aggaatgtag tgttttagat attaattcta     6175

tttttattta ttcattttta catcaccaat aggatctgag gtggagatgg cgggtattat     6235

cactggcatt ttacaggtga gaaagcccaa agccactgag gtaattaatg gaataattga     6295

ttttgaactt gggtctgtct gatttcatgt gcaagattat atacttagtg attttgattt     6355

taagtttatt cttaacattt taaaccagac tattaactct tacctttata accacagata     6415

caaagaactg tatcatttat tttctgaata taaaatatta atggtcaata taaaaataca     6475

aaaatagaga actatataca acagaaaagc aaaattaccc actaataaca ttttgattta     6535

tatcccttta gacactgttt agagtttata catatatgta aatatgcttg tattttaaca     6595

aaattgagat attatataaa ctgtttgtag cagggtgttt aaaattttaa caatatgtta     6655

tggatatctt tctgtgtcaa taaatgtgta tttacattag a                         6696


<210>  47
<211>  1095
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Glu Gly Ala Ala Gly Arg Glu Asp Pro Ala Pro Pro Asp Ala 
1               5                   10                  15      


Ala Gly Gly Glu Asp Asp Pro Arg Val Gly Pro Asp Ala Ala Gly Asp 
            20                  25                  30          


Cys Val Thr Ala Ala Ser Gly Gly Arg Met Arg Asp Arg Arg Ser Gly 
        35                  40                  45              


Val Ala Leu Pro Gly Ala Ala Gly Thr Pro Ala Asp Ser Glu Ala Gly 
    50                  55                  60                  


Leu Leu Glu Ala Ala Arg Ala Thr Pro Arg Arg Ser Ser Ile Ile Lys 
65                  70                  75                  80  


Asp Pro Ser Asn Gln Lys Cys Gly Gly Arg Lys Lys Thr Val Ser Phe 
                85                  90                  95      


Ser Ser Met Pro Ser Glu Lys Lys Ile Ser Ser Ala Asn Asp Cys Ile 
            100                 105                 110         


Ser Phe Met Gln Ala Gly Cys Glu Leu Lys Lys Val Arg Pro Asn Ser 
        115                 120                 125             


Arg Ile Tyr Asn Arg Phe Phe Thr Leu Asp Thr Asp Leu Gln Ala Leu 
    130                 135                 140                 


Arg Trp Glu Pro Ser Lys Lys Asp Leu Glu Lys Ala Lys Leu Asp Ile 
145                 150                 155                 160 


Ser Ala Ile Lys Glu Ile Arg Leu Gly Lys Asn Thr Glu Thr Phe Arg 
                165                 170                 175     


Asn Asn Gly Leu Ala Asp Gln Ile Cys Glu Asp Cys Ala Phe Ser Ile 
            180                 185                 190         


Leu His Gly Glu Asn Tyr Glu Ser Leu Asp Leu Val Ala Asn Ser Ala 
        195                 200                 205             


Asp Val Ala Asn Ile Trp Val Ser Gly Leu Arg Tyr Leu Val Ser Arg 
    210                 215                 220                 


Ser Lys Gln Pro Leu Asp Phe Met Glu Gly Asn Gln Asn Thr Pro Arg 
225                 230                 235                 240 


Phe Met Trp Leu Lys Thr Val Phe Glu Ala Ala Asp Val Asp Gly Asn 
                245                 250                 255     


Gly Ile Met Leu Glu Asp Thr Ser Val Glu Leu Ile Lys Gln Leu Asn 
            260                 265                 270         


Pro Thr Leu Lys Glu Ala Lys Ile Arg Leu Lys Phe Lys Glu Ile Gln 
        275                 280                 285             


Lys Ser Lys Glu Lys Leu Thr Thr Arg Val Thr Glu Glu Glu Phe Cys 
    290                 295                 300                 


Glu Ala Phe Cys Glu Leu Cys Thr Arg Pro Glu Val Tyr Phe Leu Leu 
305                 310                 315                 320 


Val Gln Ile Ser Lys Asn Lys Glu Tyr Leu Asp Ala Asn Asp Leu Met 
                325                 330                 335     


Leu Phe Leu Glu Ala Glu Gln Gly Val Thr His Ile Thr Glu Asp Ile 
            340                 345                 350         


Cys Leu Asp Ile Ile Arg Arg Tyr Glu Leu Ser Glu Glu Gly Arg Gln 
        355                 360                 365             


Lys Gly Phe Leu Ala Ile Asp Gly Phe Thr Gln Tyr Leu Leu Ser Ser 
    370                 375                 380                 


Glu Cys Asp Ile Phe Asp Pro Glu Gln Lys Lys Val Ala Gln Asp Met 
385                 390                 395                 400 


Thr Gln Pro Leu Ser His Tyr Tyr Ile Asn Ala Ser His Asn Thr Tyr 
                405                 410                 415     


Leu Ile Glu Asp Gln Phe Arg Gly Pro Ala Asp Ile Asn Gly Tyr Ile 
            420                 425                 430         


Arg Ala Leu Lys Met Gly Cys Arg Ser Val Glu Leu Asp Val Ser Asp 
        435                 440                 445             


Gly Ser Asp Asn Glu Pro Ile Leu Cys Asn Arg Asn Asn Met Thr Thr 
    450                 455                 460                 


His Val Ser Phe Arg Ser Val Ile Glu Val Ile Asn Lys Phe Ala Phe 
465                 470                 475                 480 


Val Ala Ser Glu Tyr Pro Leu Ile Leu Cys Leu Gly Asn His Cys Ser 
                485                 490                 495     


Leu Pro Gln Gln Lys Val Met Ala Gln Gln Met Lys Lys Val Phe Gly 
            500                 505                 510         


Asn Lys Leu Tyr Thr Glu Ala Pro Leu Pro Ser Glu Ser Tyr Leu Pro 
        515                 520                 525             


Ser Pro Glu Lys Leu Lys Arg Met Ile Ile Val Lys Gly Lys Lys Leu 
    530                 535                 540                 


Pro Ser Asp Pro Asp Val Leu Glu Gly Glu Val Thr Asp Glu Asp Glu 
545                 550                 555                 560 


Glu Ala Glu Met Ser Arg Arg Met Ser Val Asp Tyr Asn Gly Glu Gln 
                565                 570                 575     


Lys Gln Ile Arg Leu Cys Arg Glu Leu Ser Asp Leu Val Ser Ile Cys 
            580                 585                 590         


Lys Ser Val Gln Tyr Arg Asp Phe Glu Leu Ser Met Lys Ser Gln Asn 
        595                 600                 605             


Tyr Trp Glu Met Cys Ser Phe Ser Glu Thr Glu Ala Ser Arg Ile Ala 
    610                 615                 620                 


Asn Glu Tyr Pro Glu Asp Phe Val Asn Tyr Asn Lys Lys Phe Leu Ser 
625                 630                 635                 640 


Arg Ile Tyr Pro Ser Ala Met Arg Ile Asp Ser Ser Asn Leu Asn Pro 
                645                 650                 655     


Gln Asp Phe Trp Asn Cys Gly Cys Gln Ile Val Ala Met Asn Phe Gln 
            660                 665                 670         


Thr Pro Gly Pro Met Met Asp Leu His Thr Gly Trp Phe Leu Gln Asn 
        675                 680                 685             


Gly Gly Cys Gly Tyr Val Leu Arg Pro Ser Ile Met Arg Asp Glu Val 
    690                 695                 700                 


Ser Tyr Phe Ser Ala Asn Thr Lys Gly Ile Leu Pro Gly Val Ser Pro 
705                 710                 715                 720 


Leu Ala Leu His Ile Lys Ile Ile Ser Gly Gln Asn Phe Pro Lys Pro 
                725                 730                 735     


Lys Gly Ala Cys Ala Lys Gly Asp Val Ile Asp Pro Tyr Val Cys Ile 
            740                 745                 750         


Glu Ile His Gly Ile Pro Ala Asp Cys Ser Glu Gln Arg Thr Lys Thr 
        755                 760                 765             


Val Gln Gln Asn Ser Asp Asn Pro Ile Phe Asp Glu Thr Phe Glu Phe 
    770                 775                 780                 


Gln Val Asn Leu Pro Glu Leu Ala Met Ile Arg Phe Val Val Leu Asp 
785                 790                 795                 800 


Asp Asp Tyr Ile Gly Asp Glu Phe Ile Gly Gln Tyr Thr Ile Pro Phe 
                805                 810                 815     


Glu Cys Leu Gln Pro Gly Tyr Arg His Val Pro Leu Arg Ser Phe Val 
            820                 825                 830         


Gly Asp Ile Met Glu His Val Thr Leu Phe Val His Ile Ala Ile Thr 
        835                 840                 845             


Asn Arg Ser Gly Gly Gly Lys Ala Gln Lys Arg Ser Leu Ser Val Arg 
    850                 855                 860                 


Met Gly Lys Lys Val Arg Glu Tyr Thr Met Leu Arg Asn Ile Gly Leu 
865                 870                 875                 880 


Lys Thr Ile Asp Asp Ile Phe Lys Ile Ala Val His Pro Leu Arg Glu 
                885                 890                 895     


Ala Ile Asp Met Arg Glu Asn Met Gln Asn Ala Ile Val Ser Ile Lys 
            900                 905                 910         


Glu Leu Cys Gly Leu Pro Pro Ile Ala Ser Leu Lys Gln Cys Leu Leu 
        915                 920                 925             


Thr Leu Ser Ser Arg Leu Ile Thr Ser Asp Asn Thr Pro Ser Val Ser 
    930                 935                 940                 


Leu Val Met Lys Asp Ser Phe Pro Tyr Leu Glu Pro Leu Gly Ala Ile 
945                 950                 955                 960 


Pro Asp Val Gln Lys Lys Met Leu Thr Ala Tyr Asp Leu Met Ile Gln 
                965                 970                 975     


Glu Ser Arg Phe Leu Ile Glu Met Ala Asp Thr Val Gln Glu Lys Ile 
            980                 985                 990         


Val Gln Cys Gln Lys Ala Gly Met  Glu Phe His Glu Glu  Leu His Asn 
        995                 1000                 1005             


Leu Gly  Ala Lys Glu Gly Leu  Lys Gly Arg Lys Leu  Asn Lys Ala 
    1010                 1015                 1020             


Thr Glu  Ser Phe Ala Trp Asn  Ile Thr Val Leu Lys  Gly Gln Gly 
    1025                 1030                 1035             


Asp Leu  Leu Lys Asn Ala Lys  Asn Glu Ala Ile Glu  Asn Met Lys 
    1040                 1045                 1050             


Gln Ile  Gln Leu Ala Cys Leu  Ser Cys Gly Leu Ser  Lys Ala Pro 
    1055                 1060                 1065             


Ser Ser  Ser Ala Glu Ala Lys  Ser Lys Arg Ser Leu  Glu Ala Ile 
    1070                 1075                 1080             


Glu Glu  Lys Glu Ser Ser Glu  Glu Asn Gly Lys Leu  
    1085                 1090                 1095 


<210>  48
<211>  3118
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (340)..(1686)

<400>  48
tctcattgca ttgcgcagag ctcagccatc tttctcatcc gtcaggcatt cctgagaaag       60

agggccactc tacctctctt gctgccagcc ttcactccag caaggagggt gctgggtgac      120

ctgagcccac atagccccga gcacccgaag cacacacagc agagtcctct ggactttgag      180

gaagaaccca cagcaggagg aagtcagcag ggagtggctg tgtgaaacct gggaccactt      240

ctgccttcct acgtggcagt ggctcagagt tatttgagtg ctgtcaaact gagctgattg      300

ctgccctagt attagatcag tccatagaaa gtgggagca atg gca ctg aca ctg         354
                                           Met Ala Leu Thr Leu            
                                           1               5              

cta gag gat tgg tgc aag ggg atg gac atg gac ccc aga aag gcc ctg        402
Leu Glu Asp Trp Cys Lys Gly Met Asp Met Asp Pro Arg Lys Ala Leu           
                10                  15                  20                

ctg att gta ggc atc ccc atg gag tgt agt gag gtg gaa att cag gac        450
Leu Ile Val Gly Ile Pro Met Glu Cys Ser Glu Val Glu Ile Gln Asp           
            25                  30                  35                    

act gtg aag gca ggc tta cag ccc ctg tgc gca tac agg gtc cta ggg        498
Thr Val Lys Ala Gly Leu Gln Pro Leu Cys Ala Tyr Arg Val Leu Gly           
        40                  45                  50                        

aga atg ttc agg agg gaa gac aat gcc aag gca gtc ttc att gaa ctg        546
Arg Met Phe Arg Arg Glu Asp Asn Ala Lys Ala Val Phe Ile Glu Leu           
    55                  60                  65                            

gct gac act gtc aat tac act act ctg ccc agt cac ata cca gga aag        594
Ala Asp Thr Val Asn Tyr Thr Thr Leu Pro Ser His Ile Pro Gly Lys           
70                  75                  80                  85            

ggt ggc tcc tgg gaa gtg gtg gta aaa ccc cgt aac cca gat gat gag        642
Gly Gly Ser Trp Glu Val Val Val Lys Pro Arg Asn Pro Asp Asp Glu           
                90                  95                  100               

ttt ctc agt aga ctg aac tac ttc ctg aaa gat gag ggc cga agt atg        690
Phe Leu Ser Arg Leu Asn Tyr Phe Leu Lys Asp Glu Gly Arg Ser Met           
            105                 110                 115                   

aca gat gtg gcc aga gcc ctg gga tgt tgc agc ctc cct gcc gag agc        738
Thr Asp Val Ala Arg Ala Leu Gly Cys Cys Ser Leu Pro Ala Glu Ser           
        120                 125                 130                       

ctg gat gca gag gtc atg ccc caa gtt aga tcc cca cct tta gag cct        786
Leu Asp Ala Glu Val Met Pro Gln Val Arg Ser Pro Pro Leu Glu Pro           
    135                 140                 145                           

ccg aaa gaa agt atg tgg tac agg aaa ctg aaa gtg ttt tcg gga act        834
Pro Lys Glu Ser Met Trp Tyr Arg Lys Leu Lys Val Phe Ser Gly Thr           
150                 155                 160                 165           

gct tcc cct agc cca ggc gaa gag acc ttt gaa gac tgg cta gag cag        882
Ala Ser Pro Ser Pro Gly Glu Glu Thr Phe Glu Asp Trp Leu Glu Gln           
                170                 175                 180               

gtc act gag ata atg ccc ata tgg caa gtg tct gag gtg gag aag agg        930
Val Thr Glu Ile Met Pro Ile Trp Gln Val Ser Glu Val Glu Lys Arg           
            185                 190                 195                   

cgg cgt ttg ctg gag agc tta cgt ggg cct gct ctg tca atc atg cgg        978
Arg Arg Leu Leu Glu Ser Leu Arg Gly Pro Ala Leu Ser Ile Met Arg           
        200                 205                 210                       

gtg ctc cag gcc aac aat gac tcc ata act gtg gag cag tgc ctt gac       1026
Val Leu Gln Ala Asn Asn Asp Ser Ile Thr Val Glu Gln Cys Leu Asp           
    215                 220                 225                           

gcc cta aag cag atc ttt ggg gat aaa gag gac ttt aga gcc tct cag       1074
Ala Leu Lys Gln Ile Phe Gly Asp Lys Glu Asp Phe Arg Ala Ser Gln           
230                 235                 240                 245           

ttt agg ttt ctg cag acc tct ccg aag att gga gag aaa gtc tcc act       1122
Phe Arg Phe Leu Gln Thr Ser Pro Lys Ile Gly Glu Lys Val Ser Thr           
                250                 255                 260               

ttc ctg ctg cgc tta gag ccc ctg ctg cag aaa gcc gtg cac aag agc       1170
Phe Leu Leu Arg Leu Glu Pro Leu Leu Gln Lys Ala Val His Lys Ser           
            265                 270                 275                   

ccc ttg tca gtg cgc agc aca gac atg att cgt ctg aaa cat ctc tta       1218
Pro Leu Ser Val Arg Ser Thr Asp Met Ile Arg Leu Lys His Leu Leu           
        280                 285                 290                       

gct cgg gtc gcc atg acc ccc gcc ctc agg ggc aag ctg gag ctc ttg       1266
Ala Arg Val Ala Met Thr Pro Ala Leu Arg Gly Lys Leu Glu Leu Leu           
    295                 300                 305                           

gat cag cga ggg tgt cct ccc aat ttt ctg gag tta atg aag ctc att       1314
Asp Gln Arg Gly Cys Pro Pro Asn Phe Leu Glu Leu Met Lys Leu Ile           
310                 315                 320                 325           

cga gat gaa gaa gag tgg gag aac act gag gca gtg atg aag aat aag       1362
Arg Asp Glu Glu Glu Trp Glu Asn Thr Glu Ala Val Met Lys Asn Lys           
                330                 335                 340               

gag aag cca tca ggg aga ggc cgg ggg gcc tcc ggt aga cag gca aga       1410
Glu Lys Pro Ser Gly Arg Gly Arg Gly Ala Ser Gly Arg Gln Ala Arg           
            345                 350                 355                   

gca gaa gcc agt gtc tct gca cct cag gcc acc gtg cag gca agg tct       1458
Ala Glu Ala Ser Val Ser Ala Pro Gln Ala Thr Val Gln Ala Arg Ser           
        360                 365                 370                       

ttt agc gac agc agc ccc cag acc ata cag gga ggc tta ccc cca tta       1506
Phe Ser Asp Ser Ser Pro Gln Thr Ile Gln Gly Gly Leu Pro Pro Leu           
    375                 380                 385                           

gtg aaa cgc agg cgg ctg tta ggc agt gaa agc act agg gga gaa gac       1554
Val Lys Arg Arg Arg Leu Leu Gly Ser Glu Ser Thr Arg Gly Glu Asp           
390                 395                 400                 405           

cat ggc cag gcc acg tat ccc aag gct gaa aac cag act cca ggc agg       1602
His Gly Gln Ala Thr Tyr Pro Lys Ala Glu Asn Gln Thr Pro Gly Arg           
                410                 415                 420               

gag ggg cca cag gct gca gga gag gag ttg gga aac gag gca ggg gct       1650
Glu Gly Pro Gln Ala Ala Gly Glu Glu Leu Gly Asn Glu Ala Gly Ala           
            425                 430                 435                   

ggg gcc atg agc cat ccc aag ccc tgg gaa aca tag gctcagaaga            1696
Gly Ala Met Ser His Pro Lys Pro Trp Glu Thr                               
        440                 445                                           

ccgaagcact ccttcccctg gcaggcagca gggacatttg aacaagggga aggggcagct     1756

tacactaaca gggaacttga ctggggcaga gggacaggga agccaggtcg agatcaagcc     1816

cccttacttt ccaccagctg gaagggactt caccaaccaa gaccaaatag catctggttc     1876

agtgggggcc gggcccatag cccctaacag gtacaggaga cacaagcggg gaaccactac     1936

acttagcaca tggggtgcct gggcttcaga tggggacccc agcgaagcag gggctgaaga     1996

aggtgtggct gggggctctg gcctggtcct ctggacaccc ccaaatatct accctgtgga     2056

ctttgagctg agcatgccca ctggcaccca ggccacgtgg gacctggagg agcctgcctg     2116

gggcctgcct ctgccagaag gagccagggc tgctgaggaa gagctgtggg gcagaagtga     2176

agccccgcag gggaggccac agggtccagc ctgtctttag gatcatctac actgcatgag     2236

gggagcccca ggaaggcagc attcataagc ccctgcacca gtgaggaaga gaaagaggag     2296

gagaattaag aagaggatga tcgggaggag gaagaggaga ataaggagga gcaggaggaa     2356

gagggggagg agaaggagga agagggggag gaggaagagg ggaaggagga ggaagaagtg     2416

taagaagaga agagaggatg tgttgggggt gggtagttgt ttttggtttg cgtcatcatc     2476

aggcccgggc tctgctcact gctgttccgt gtcaagaact ccacctctgc tttgccggtg     2536

tagatctcgg ccagtggctg cttgttctct tggggatgtg tgtgttttta tctgagcagc     2596

tcctttccag agtaccccag cgcagttcca ggagacggtg ggaaggaggc atggcagacg     2656

ctcaccttgt gactgtgacc tcgactgcag gaggaccaac cagacacggg aaggagcagg     2716

gctgcctgag gctccccagg aagctttgtg ctttggcgtt ccacccctgc tgttactcgt     2776

gactcagttt cctcaacttg gtggggtgtt ccctgctatg ttttccagca tcctgtgact     2836

gtcctgtgca gtctataggg cagggccctg ccccagcggg tgggctcagg agggggttcc     2896

ctgaagcgag tacacattgc cagagcccac catcctggca agaggtggat cctggggccc     2956

tatggaagga gggatgtggt ggggggggcc acactgaggg aggggccggg gacttgtgac     3016

ctgtagtggc tgtttgcagt ttctctctgt gttagattcc cttttcttca gcagtttcag     3076

ttcatgtttc tcttcagtaa attttgttca gtgttccaaa aa                        3118


<210>  49
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Leu Thr Leu Leu Glu Asp Trp Cys Lys Gly Met Asp Met Asp 
1               5                   10                  15      


Pro Arg Lys Ala Leu Leu Ile Val Gly Ile Pro Met Glu Cys Ser Glu 
            20                  25                  30          


Val Glu Ile Gln Asp Thr Val Lys Ala Gly Leu Gln Pro Leu Cys Ala 
        35                  40                  45              


Tyr Arg Val Leu Gly Arg Met Phe Arg Arg Glu Asp Asn Ala Lys Ala 
    50                  55                  60                  


Val Phe Ile Glu Leu Ala Asp Thr Val Asn Tyr Thr Thr Leu Pro Ser 
65                  70                  75                  80  


His Ile Pro Gly Lys Gly Gly Ser Trp Glu Val Val Val Lys Pro Arg 
                85                  90                  95      


Asn Pro Asp Asp Glu Phe Leu Ser Arg Leu Asn Tyr Phe Leu Lys Asp 
            100                 105                 110         


Glu Gly Arg Ser Met Thr Asp Val Ala Arg Ala Leu Gly Cys Cys Ser 
        115                 120                 125             


Leu Pro Ala Glu Ser Leu Asp Ala Glu Val Met Pro Gln Val Arg Ser 
    130                 135                 140                 


Pro Pro Leu Glu Pro Pro Lys Glu Ser Met Trp Tyr Arg Lys Leu Lys 
145                 150                 155                 160 


Val Phe Ser Gly Thr Ala Ser Pro Ser Pro Gly Glu Glu Thr Phe Glu 
                165                 170                 175     


Asp Trp Leu Glu Gln Val Thr Glu Ile Met Pro Ile Trp Gln Val Ser 
            180                 185                 190         


Glu Val Glu Lys Arg Arg Arg Leu Leu Glu Ser Leu Arg Gly Pro Ala 
        195                 200                 205             


Leu Ser Ile Met Arg Val Leu Gln Ala Asn Asn Asp Ser Ile Thr Val 
    210                 215                 220                 


Glu Gln Cys Leu Asp Ala Leu Lys Gln Ile Phe Gly Asp Lys Glu Asp 
225                 230                 235                 240 


Phe Arg Ala Ser Gln Phe Arg Phe Leu Gln Thr Ser Pro Lys Ile Gly 
                245                 250                 255     


Glu Lys Val Ser Thr Phe Leu Leu Arg Leu Glu Pro Leu Leu Gln Lys 
            260                 265                 270         


Ala Val His Lys Ser Pro Leu Ser Val Arg Ser Thr Asp Met Ile Arg 
        275                 280                 285             


Leu Lys His Leu Leu Ala Arg Val Ala Met Thr Pro Ala Leu Arg Gly 
    290                 295                 300                 


Lys Leu Glu Leu Leu Asp Gln Arg Gly Cys Pro Pro Asn Phe Leu Glu 
305                 310                 315                 320 


Leu Met Lys Leu Ile Arg Asp Glu Glu Glu Trp Glu Asn Thr Glu Ala 
                325                 330                 335     


Val Met Lys Asn Lys Glu Lys Pro Ser Gly Arg Gly Arg Gly Ala Ser 
            340                 345                 350         


Gly Arg Gln Ala Arg Ala Glu Ala Ser Val Ser Ala Pro Gln Ala Thr 
        355                 360                 365             


Val Gln Ala Arg Ser Phe Ser Asp Ser Ser Pro Gln Thr Ile Gln Gly 
    370                 375                 380                 


Gly Leu Pro Pro Leu Val Lys Arg Arg Arg Leu Leu Gly Ser Glu Ser 
385                 390                 395                 400 


Thr Arg Gly Glu Asp His Gly Gln Ala Thr Tyr Pro Lys Ala Glu Asn 
                405                 410                 415     


Gln Thr Pro Gly Arg Glu Gly Pro Gln Ala Ala Gly Glu Glu Leu Gly 
            420                 425                 430         


Asn Glu Ala Gly Ala Gly Ala Met Ser His Pro Lys Pro Trp Glu Thr 
        435                 440                 445             


<210>  50
<211>  8861
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (135)..(818)

<400>  50
agtgctgatg ttggagccgg ttagcgaacc ccaagagtgc agagtgtgga gcgtggagcg       60

ccgggactgt gcacgcttga ccggaagccc agaccagtgc ggtcctagcc agagagaaag      120

gacatttgcc aaca atg aga cac gaa gcg ccc atg cag atg gcc tct gcc        170
                Met Arg His Glu Ala Pro Met Gln Met Ala Ser Ala           
                1               5                   10                    

caa gat gcc agg tac ggc cag aaa gac tcc tct gat cag aac ttt gac        218
Gln Asp Ala Arg Tyr Gly Gln Lys Asp Ser Ser Asp Gln Asn Phe Asp           
        15                  20                  25                        

tac atg ttc aaa tta ctc atc atc ggc aat agc agt gtg ggg aaa aca        266
Tyr Met Phe Lys Leu Leu Ile Ile Gly Asn Ser Ser Val Gly Lys Thr           
    30                  35                  40                            

tct ttt cta ttc cgt tat gca gat gac tcc ttt aca tct gca ttc gtc        314
Ser Phe Leu Phe Arg Tyr Ala Asp Asp Ser Phe Thr Ser Ala Phe Val           
45                  50                  55                  60            

agc aca gtt ggg atc gat ttc aaa gta aaa act gta ttc aaa aat gaa        362
Ser Thr Val Gly Ile Asp Phe Lys Val Lys Thr Val Phe Lys Asn Glu           
                65                  70                  75                

aag aga atc aag ctt cag att tgg gac aca gca ggc cag gaa aga tac        410
Lys Arg Ile Lys Leu Gln Ile Trp Asp Thr Ala Gly Gln Glu Arg Tyr           
            80                  85                  90                    

agg act atc acc aca gcc tat tat cgt gga gcc atg ggc ttt att tta        458
Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly Ala Met Gly Phe Ile Leu           
        95                  100                 105                       

atg tat gac att aca aat gaa gaa tcc ttc aat gca gta caa gat tgg        506
Met Tyr Asp Ile Thr Asn Glu Glu Ser Phe Asn Ala Val Gln Asp Trp           
    110                 115                 120                           

tca act caa atc aaa aca tac tct tgg gac aat gcc caa gtt att ctg        554
Ser Thr Gln Ile Lys Thr Tyr Ser Trp Asp Asn Ala Gln Val Ile Leu           
125                 130                 135                 140           

gtt ggg aac aag tgt gac atg gaa gac gag cgg gtc atc tca act gag        602
Val Gly Asn Lys Cys Asp Met Glu Asp Glu Arg Val Ile Ser Thr Glu           
                145                 150                 155               

cga ggt caa cat tta gga gaa cag ctt ggg ttt gag ttt ttt gaa aca        650
Arg Gly Gln His Leu Gly Glu Gln Leu Gly Phe Glu Phe Phe Glu Thr           
            160                 165                 170                   

agt gcc aag gac aac att aat gtc aag cag aca ttt gag cgc ctt gtg        698
Ser Ala Lys Asp Asn Ile Asn Val Lys Gln Thr Phe Glu Arg Leu Val           
        175                 180                 185                       

gat atc atc tgc gac aaa atg tca gag agt ttg gag act gat cct gcc        746
Asp Ile Ile Cys Asp Lys Met Ser Glu Ser Leu Glu Thr Asp Pro Ala           
    190                 195                 200                           

atc act gct gca aag cag aac acg aga ctc aag gaa act cct cct cca        794
Ile Thr Ala Ala Lys Gln Asn Thr Arg Leu Lys Glu Thr Pro Pro Pro           
205                 210                 215                 220           

ccg cag ccc aac tgt gcc tgc tag tgtccccgtg cacacaggca gctccagggg       848
Pro Gln Pro Asn Cys Ala Cys                                               
                225                                                       

gctctggttg ccaacaaaca gcatttgtaa atggtctatt agccttcatt tatactgcct      908

aacaattatt tgaaggaata aattgatgtc aatggctcgt acgcattcaa ttcttgggag      968

ctttcctgtt taatatgtgg caaatatgtg atcttaaatt tataaggact atccatctat     1028

aaacatctgg tacctgcatg tgacttgtta tttatttgtc tgctaggctc tttttgtttc     1088

aaatttgttc tcagactact tctgggacat cagactataa tctcactaca actggctttt     1148

gtcccattga ttcaaattat gctattcact tgtaggaatg atgaccaagg aattgcttgt     1208

gtgtgtgtgt gtgtgtgtgt gtgtgcacgc atgcccgcat gcgtgcagag gaagaagtca     1268

caagacttca tttgctttac tcttagttga aaatcaaatg gaagtttttc tcatgattag     1328

ggacgctgtc acgagtctgg tcagtttact gttgggaact gtgtctttat ttcactgtta     1388

ttaataactg agatcattgg cctataaaga aattgaaatg ttgtttttaa ggtccttgca     1448

attttcctaa gtcattaata ttacctgact ggggctattt aacaataatc ttcgtttaca     1508

catttaaata agcaagtatc tacccaggac tgctttttcc actgatcctt cccaattctg     1568

tgaatattca acatcattga acagattgag acatatctac tgaatgccag ttatgcaaca     1628

agcattttaa ccaagaaggg tatgagtagc tatggaattc caaggtccaa gcccccttat     1688

ttttcaatga cttgccttcc ccaaccccca taatgcacac caccaccacc atcactttct     1748

ggaaccatca ccaactcttg gactagagct tatgttgaag cttgttaggg ctcctctttc     1808

cgtaggatgt agacttgcct ccccaaacac ggccatcttc tcaaacctca gctaagttct     1868

tttacctgtt tagatgctat ttaaatcaga tttcaaaggg tccccagttg agaaaaagga     1928

aaattttaat ctttaatcat ctttttaagt ccagatgttc ataaattcta aagcatattc     1988

ctattacgtg aatgcttaag ttacacagga aacattctat aactgtagta tttcaatttc     2048

agaaatattt aggatccata gcaatttaaa agagggagga aaccactgga gcattctaat     2108

tttgtatcac aaacttccta aaggacctat atgaataaag agaaaacaac aaatcctacc     2168

agctgtacag agagcaacag ggaaatttgg cctctgtatc actgtccagc attatttaaa     2228

gctaggattt aggaaggaag caggaattat ttggcagatt tggaaggata gtttcgttaa     2288

gtgaactttc tacttttttg gtggttatgt caaagaattt ttttcctctt ctcaaaaata     2348

gagaggcttc ccatgaaagt attggatgca aatgaaacag gcatacatct aaagatatct     2408

ttggagaata aatccttaca agtcacagaa ctaggtcaca cacattagta agtcaaaagt     2468

tggaaattag gggagagagc atttggaatg ctttaagcat ttccatgtta tttctcacct     2528

tcctagttga agatccacta atcagtagta catttctact ttggtgccct acaaagcaaa     2588

ccttagcata gtaaagacaa gaaaacatta atgttttatt agtttttaat ggggcaacca     2648

acttcaaaat cacaggaatt acagtgacgg gagagaaaga agcaggaggc ataaaaacag     2708

atttgtttgt agcagtagtc tgtttgtaca atgttataat atttctgtaa cttgggccag     2768

aatgtggcca tgttaaatga tatagctatt aagctcactt ttacaatcta aaaggaacta     2828

ataaagccag gaaacccttc tcatcctcct tcacagccct catcccacac atagatgtaa     2888

aaagcttaga aagaatattc tgatggcttt ttcagaagga aggaccttga tgtgtgtatt     2948

gtggtaaaat gaaaagcaaa atgagacagt atttaaaagt gaaagagcag agttttgctc     3008

tgctgaaaac cccttccctg aagaactgat tgctgttgaa gttaattggc ccttagatgg     3068

gaagccctaa gccaagctcc cacttacaca gtgtcaaaca tcccgaagtg gaaacatttt     3128

atgccagtca ggggagagac aggcaacaat agcccaaatg tcattgccaa gaaacatctg     3188

atactttcta atttctaaac cccaatggaa gtgaggcctt tttcattgat tctcagttct     3248

gaaactccca ccctgttagg atttccattc caaataattc aatgagaggt ttccagagaa     3308

acagtcacag agctcaagag aaagaacact taaatgctcc tgctgtaatt gcatcaaaaa     3368

atccgggttt taacatcaaa tttggcaaat ggtgggacca acccaaggtt aactaagtgg     3428

gctttcattg gcattgagct atgttactta taaattataa cactatagtt ccaaggtttt     3488

tcagcctttt ggccaacaca cacacacaca cacacacaca cacacacaca cactatacca     3548

tcatctatca atagtctaaa tacataaata aatgcaggtc atttttatca atggcctaac     3608

taaatttata tttaaaagaa caagactttt aaaaagtaca tactcctgtt ggtttgtaag     3668

ttatacacat ttatctcttg tctttgattt aattaaatta gtgttttaag tatgaattta     3728

ttttcctttg ctactcatta cctgaccact ttcactcctc tagataccct taggaataaa     3788

cctgaactgt tccaaatcga ttcttccaag agctttggtg ttggtacctt cctttctttt     3848

cctaatgcaa ctgaaaaatt agactgaaaa ttatttgact taaatagcca tcctcagagt     3908

gaatcagcat ttcagttttt ggagatgggg atggaagtag aaggtgcaca aagcgtccta     3968

agatggcagt ttgaatgtta gcatcgcatc tacatgctca taagaggaat tgcttcagga     4028

caatgaatca gttcattgtt gctgccccca gtgaacagct ccaactgcct tgatgaactt     4088

ctaatgactg tgaaagctag gaggttcttc tagttcctcc ttagggtcac ttgaagttca     4148

gtattttttt gctgcctggt aactaagtgc taagattttt acttggaaag aaaactatga     4208

caatgccttc agttgtagca gaaagttgtg gcattgtgat aataaacaaa atctacaaag     4268

ttacaaccca aattatacaa gacatcaaaa cactcagtaa acaaatatat atatttcacc     4328

tacttaaatc ttattcatat taattatagg ccttttgttt agtacactgg ttatttttta     4388

aggaaccaat ttaaactttc aattttaaat acatctatgc tgacgataga ctttcgggta     4448

tatacaacct tcttcttctc ttttaaaagt taaatacatt ccactattaa ctgaacttcc     4508

atgaagcaac attaatttta gagcatggta gtccataatc agtggttcat tgtgatgtgc     4568

tttatccaac atgtatctta gtgcatggtt gaggatgtac tatgtgatat tttagttaac     4628

agtgtggcat ttgtgggact atattaaaag catatccaaa ctaccaagct ataccaagct     4688

gaggtaggta acacctgcat gtgaaaaact gtgatatgaa tcttatttat aaaaaagtca     4748

taactaaaac ccttctagac caaaaagtta ctgtgtgttt gttaataatc ttcatagtac     4808

tactggaatg ctcaatcagt tatttttggt gtggcatact tcagagctgg cctgtccgtc     4868

tgaagaaccc tttctctcac aattacagtt tgcatgacta gaacccggaa ctctgttcct     4928

ttgcgtgtat agtcacttag tgtgctgtcc gggtgccaca tgagcaacta cacccatgtg     4988

gcctttctgt cactccctgg aaaatgcaac ctctacagct ctgctcagct ctgcctgtgt     5048

gcattgatta ccttcgcttt agtagtttgc ctgtaaaatg gtgaagtctt tctgatatgc     5108

tgaacctttg agccagcttt tgggagttct tcatatttta ggtgaatttt tgaccaaagt     5168

caattaaaga cataaacctg ttttatatca tggaatttac tgggccaaat taagtaaaag     5228

atgaagttta tgaccagaat aaaaaagcct ttacccctgc acagcactgt atctaaaggg     5288

ctctaggttg tagaaatata gtacccccta acagggaaaa accaagttgg gggatttatc     5348

taaaatgtat ctacctattg ttactggtat ttcacaaata atttttttct taaaaatatt     5408

tacagaaatg cttgacactc cggtcaaata atatttccct ttgatagatt gaaatatttg     5468

cttttagatt acacatacag tgctgccctt ctcaacagtc actcacacgc tcactcgcct     5528

gtacaaaggt atcaggcaaa cactgatact tttttttaag aaggcaaaat tccatctatg     5588

gtgctttctc agtgctaggg aaaagggagc ttttactatg ttccagctat aactcacatc     5648

ttacttataa ggtccataaa atcggttctt cacactgatt tcgtttgatt agtctgtgca     5708

tgtaattaat ttcctccaaa cagagagagt ggaggggaaa taaattttgc aagcattcta     5768

gataacagaa atgagtcatt ttaaaacctc actcagagct cgagtgttaa gatcagacca     5828

tctagctagt ggacaaattg aactttctat ttgcagttct cttttacttt ctgactttct     5888

tttaaattac tgcagttttt caaaacacta tcctcatgga atgacaggac caagaataga     5948

aaatgagact caaatttcac catttacttc ccatcagcaa ccattactgg tggagtttca     6008

aacagtcatt acttgctgaa atgaggtttg aggttacctg tgtatttcat tcacctgtgt     6068

taatatttcc ttcatcgtgg acaagtgaga gttggctgtg gctttatttc ttgaggcaaa     6128

ttattttgca ttcatgttat ttggggctag gtattgctta ggttcgtgaa tgctgttctt     6188

acagacacag atggtacctg agcccctcag acacctgccc tttcagggac gtgagcatga     6248

cttacatctg tcaagtggtt ccatacttct tgtaaaagta aagtttgggt attgtttgct     6308

gtatcaatat gatggctttc catgcattgt ctcattatcc ctaggatacg tgctaaagga     6368

aaactgtcct gtaattcctg ttaatatatt gttaatgtca gacgtgatgt gataccgtta     6428

gactgtccaa atgtacaaca atttaatggt gtttgtagaa ctgatatgtc ttaaatgttg     6488

catgaaatat gttataaaaa tagatttgtt ttctattttc aacacctcag aattgagggt     6548

tcatgggcca ataagtgcaa tatttaatga ctcactcagt gtatataaac tagtatgaaa     6608

gagtgaatta taatgaatgt gtgagatgct ttgatagctg tgtgacttat tcaaatgatt     6668

ttcttgtagc tgtatttgtc tagtggtgca atttatacag taaatatctt attggtgtca     6728

tgtaaaaccc ctctgtgcct acttcaaaat acttttttct tataaaacca aacatttagt     6788

atctggaaat atgtgtcaat tttatctctt agaattgtgg attttattgt caagacagaa     6848

tggctgttca tttattttat aaaagcatct ccttctataa ctcaaaattt tctttaagtg     6908

tcatataaaa gtgtacattt tacttttaag caactaattt agatacctaa gaaaaactat     6968

gtgcattagg aaaagtcatg tttttcttct cagaaaggtt gatcacatga catgtctact     7028

aagaattttc acctctgtac ttgtatgtat attttattgt tactcaatct tgtattttat     7088

ttacaaattc aacactgtca accctgggaa ttctaaaata ccaatgtatt tttaggttgt     7148

agctaatgtt gtattcactt tcaattctca gttgtccaca ctggtgatat aagaggaaca     7208

aatcagaatc attaaatact ttgtaatgcc atcataaact catatattca tcctcaaact     7268

cccttgttta atgctaattg gtggcctgga acttcactga gatgcaaaat caagaactga     7328

agcctagttg ctagataacg aaaagctata aatgtttatg tatgtgaatt ttaaattaga     7388

ataaccgtct taaactccta cttgccattt ctaaggcaaa gcattcattt taatattgta     7448

ctttgccttt tcattcagtt agtggagtaa gtcatgaaac ccttaggaag aaaaacaagt     7508

tatgacttat tcactaaaat tgatgcaaga cagttggttc tagatgacca tggccatgtg     7568

ttcatcatat aaaaccttca gttctctcta tggtgcttgg ctggagattg acatgtgagg     7628

atgtgccaat catattaaat ggatttggtc tatgtgggtg atatgtggcc tgaatgtaac     7688

tgtgatagac tgaaatttgt tcttagctct caaaatccac tgaagaagtc aagtgaaggt     7748

gggtaaaata gggagattag tgacaacttt gtgccaaatt ttttaaaaaa tggaagcagg     7808

tagccaatat tagaatgata atttaagggt gtggttgaat tttagttagt tgtcacatag     7868

ttattgaacc tcatatgctc agtgctgtgg gaatcaaaca tggaagaggt atggctcctg     7928

cccctaatga gaacaagggg gaaaaatcca gatataatct aaatgctagg ttatgtcagg     7988

gtataggaac acagagaatg ggggacctgt aagaactgga agagtcagag agggctccat     8048

tgaagaggtc aaacataatt ccggaaagaa ttaggtagtg aggagattgt gccaggaaaa     8108

taagtgggaa aggccacagt tatgtttcct ttgaatggaa gagagacaaa gctatcagct     8168

atagatcatt gttttcttaa gacagccaaa ctggcccttt gaaaccattc aaattacccc     8228

agtttagctc cctacctttt agtctccgtg aggaagacaa gctgttgcat tatcatattc     8288

ctctgtgctg agcagctcaa gactcagcca caatatgcaa attgctttaa tgccatatta     8348

cggcagttga tttagacatt tgccagtgca ccaaaccatg agagattgtc cgacctaatg     8408

ccacctggca gatgtgtacc cagagatttt tctgtagctc catgtttccc ataaagggca     8468

ttggaaatgc acagatgaag atcttccttt ggaaccaggc acatttggcc ccttctcagt     8528

gactgcactg tggaactctt cttaagaaaa tattgaaaac agcttaatgc tttcatatag     8588

tgaccgacat ttagttgaaa actactgctg catagcaaat attgtgactc ttcatgtgtc     8648

cacaggagct cttgtgtggg tttaaagcta tgaagtgtat tcacattgtg aagttttaat     8708

tatctttatt gaaattaatt gtgtaaaaat ggtatgtgct ctattaggta ttcagtttgt     8768

atgtgaattc tataaagaaa gtggtttttg ttctttgagt ttgttttatt tcttgaagat     8828

tacaataaat atctaagaga ctatattcct gaa                                  8861


<210>  51
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Arg His Glu Ala Pro Met Gln Met Ala Ser Ala Gln Asp Ala Arg 
1               5                   10                  15      


Tyr Gly Gln Lys Asp Ser Ser Asp Gln Asn Phe Asp Tyr Met Phe Lys 
            20                  25                  30          


Leu Leu Ile Ile Gly Asn Ser Ser Val Gly Lys Thr Ser Phe Leu Phe 
        35                  40                  45              


Arg Tyr Ala Asp Asp Ser Phe Thr Ser Ala Phe Val Ser Thr Val Gly 
    50                  55                  60                  


Ile Asp Phe Lys Val Lys Thr Val Phe Lys Asn Glu Lys Arg Ile Lys 
65                  70                  75                  80  


Leu Gln Ile Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Thr Ile Thr 
                85                  90                  95      


Thr Ala Tyr Tyr Arg Gly Ala Met Gly Phe Ile Leu Met Tyr Asp Ile 
            100                 105                 110         


Thr Asn Glu Glu Ser Phe Asn Ala Val Gln Asp Trp Ser Thr Gln Ile 
        115                 120                 125             


Lys Thr Tyr Ser Trp Asp Asn Ala Gln Val Ile Leu Val Gly Asn Lys 
    130                 135                 140                 


Cys Asp Met Glu Asp Glu Arg Val Ile Ser Thr Glu Arg Gly Gln His 
145                 150                 155                 160 


Leu Gly Glu Gln Leu Gly Phe Glu Phe Phe Glu Thr Ser Ala Lys Asp 
                165                 170                 175     


Asn Ile Asn Val Lys Gln Thr Phe Glu Arg Leu Val Asp Ile Ile Cys 
            180                 185                 190         


Asp Lys Met Ser Glu Ser Leu Glu Thr Asp Pro Ala Ile Thr Ala Ala 
        195                 200                 205             


Lys Gln Asn Thr Arg Leu Lys Glu Thr Pro Pro Pro Pro Gln Pro Asn 
    210                 215                 220                 


Cys Ala Cys 
225         


<210>  52
<211>  4176
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (137)..(1210)

<400>  52
ccttttcttc gtagcctcca agggagctgg aacaaaaaac gaaaccaaaa cctgcctgct       60

cgctcctctc cccatcgcct gcgttccgct ggttgtgggc tttctgcggc cgctgagggc      120

gcgtctcccc tccgcc atg gca tca gtt ttg aat gtc aag gaa tcc aaa gct      172
                  Met Ala Ser Val Leu Asn Val Lys Glu Ser Lys Ala         
                  1               5                   10                  

cct gaa aga acg gtt gta gtt gct ggt ctt cca gtt gac ctt ttt agt        220
Pro Glu Arg Thr Val Val Val Ala Gly Leu Pro Val Asp Leu Phe Ser           
        15                  20                  25                        

gat caa tta ttg gcc gta tta gtg aag agc cac ttc caa gac att aag        268
Asp Gln Leu Leu Ala Val Leu Val Lys Ser His Phe Gln Asp Ile Lys           
    30                  35                  40                            

aat gag ggc gga gat gtt gaa gat gtg ata tat ccg aca aga acc aag        316
Asn Glu Gly Gly Asp Val Glu Asp Val Ile Tyr Pro Thr Arg Thr Lys           
45                  50                  55                  60            

gga gtt gca tat gta ata ttc aaa gaa aaa aaa gtt gca gag aat gtc        364
Gly Val Ala Tyr Val Ile Phe Lys Glu Lys Lys Val Ala Glu Asn Val           
                65                  70                  75                

atc aga caa aag aaa cac tgg cta gca agg aag act aga cat gct gaa        412
Ile Arg Gln Lys Lys His Trp Leu Ala Arg Lys Thr Arg His Ala Glu           
            80                  85                  90                    

ctc aca gtc tct ctc aga gtc tct cat ttt ggt gac aag atc ttc agc        460
Leu Thr Val Ser Leu Arg Val Ser His Phe Gly Asp Lys Ile Phe Ser           
        95                  100                 105                       

tct gta aat gcc atc ctt gat ctt tct gtt ttt gga aaa gaa gtt act        508
Ser Val Asn Ala Ile Leu Asp Leu Ser Val Phe Gly Lys Glu Val Thr           
    110                 115                 120                           

cta gaa act ctg gta aaa gac ctg aaa aaa aaa atc ccg agt tta agc        556
Leu Glu Thr Leu Val Lys Asp Leu Lys Lys Lys Ile Pro Ser Leu Ser           
125                 130                 135                 140           

ttc agt cct ttg aaa ccc aat gga aga atc tcc gtg gaa gga tca ttt        604
Phe Ser Pro Leu Lys Pro Asn Gly Arg Ile Ser Val Glu Gly Ser Phe           
                145                 150                 155               

ctg gct gtc aag agg ctc aga gaa tct ttg cta gca aga gca tgt tct        652
Leu Ala Val Lys Arg Leu Arg Glu Ser Leu Leu Ala Arg Ala Cys Ser           
            160                 165                 170                   

ctc tta gaa aaa gac aga aat ttt acc agt gag gag aga aag tgg aat        700
Leu Leu Glu Lys Asp Arg Asn Phe Thr Ser Glu Glu Arg Lys Trp Asn           
        175                 180                 185                       

aga caa aat ccc cag agg aat cta cag aga agt aat aac tct ttg gca        748
Arg Gln Asn Pro Gln Arg Asn Leu Gln Arg Ser Asn Asn Ser Leu Ala           
    190                 195                 200                           

tca gtc agg acc tta gta cct gag act gct aga agt gga gaa atg ctt        796
Ser Val Arg Thr Leu Val Pro Glu Thr Ala Arg Ser Gly Glu Met Leu           
205                 210                 215                 220           

gtg ctt gac aca gat gtt ttt ctt tac ctg aaa cac aag tgt gga tct        844
Val Leu Asp Thr Asp Val Phe Leu Tyr Leu Lys His Lys Cys Gly Ser           
                225                 230                 235               

tat gaa agc aca ctg aaa aaa ttc cac att ctg agt cag gag aaa gtg        892
Tyr Glu Ser Thr Leu Lys Lys Phe His Ile Leu Ser Gln Glu Lys Val           
            240                 245                 250                   

gat ggt gaa atc acc aca att tgt cta aaa agc att caa gtt ggt tct        940
Asp Gly Glu Ile Thr Thr Ile Cys Leu Lys Ser Ile Gln Val Gly Ser           
        255                 260                 265                       

cag cca aac aat gca aaa cat gta aaa gag ctc att gag gaa tgg tca        988
Gln Pro Asn Asn Ala Lys His Val Lys Glu Leu Ile Glu Glu Trp Ser           
    270                 275                 280                           

cat gct ctt tac tta aag ctt aga aaa gag aca ttt att ttg gaa gga       1036
His Ala Leu Tyr Leu Lys Leu Arg Lys Glu Thr Phe Ile Leu Glu Gly           
285                 290                 295                 300           

aag gaa aat aga gag aaa aga atg atc aaa agg gca tgt gaa caa tta       1084
Lys Glu Asn Arg Glu Lys Arg Met Ile Lys Arg Ala Cys Glu Gln Leu           
                305                 310                 315               

agt tcg aga tac ctt gaa gtc ctg att aac ctt tat agg aca cac att       1132
Ser Ser Arg Tyr Leu Glu Val Leu Ile Asn Leu Tyr Arg Thr His Ile           
            320                 325                 330                   

gac att ata gga tct tct tct gac act tac ctg ttt aaa aaa ggg gtc       1180
Asp Ile Ile Gly Ser Ser Ser Asp Thr Tyr Leu Phe Lys Lys Gly Val           
        335                 340                 345                       

atg aaa tta ata ggg caa aag gtt agt taa taaaatctca gcaatatagt         1230
Met Lys Leu Ile Gly Gln Lys Val Ser                                       
    350                 355                                               

cataagggct gctttctctt gctgagcagt gaccattgcc atgaatgagg ctagctttac     1290

acaccgtatc tcatgaatcc ttatagtcat ccttctttgt cagtgttgac tatcctcatg     1350

ttacagcgga agaaactagg atttggagaa gttaaaacac ttttctgaag ttatccagtt     1410

gacaaagaat gaggctgtgg cttagcccag tctatctgat tacacagata atatctaagg     1470

aataaaactt tgaaaaaaac tcaccaaact tttttttttt tttttttgag atggagtctc     1530

gctctgttgt ccaggctgga gtgcagtggc gtgatctcgg ctcactgcaa cgtccacctc     1590

ctgggttcac accattctcc tgcctcaacc tctggagtag ctgggactac aggtgcccac     1650

caccacgccc ggctaatctt tttgtatttt tttagtagag atggggtttc accgtgttag     1710

tcaggatggt ctccatctcc tgaccttgtg atccacccgc ctcggcctcc caaagtgctg     1770

ggattacagg cgtgagccac tgcgcccagc aaactcacca aactttgaag gaatcttact     1830

ttctctgtaa ctccaaatta ttagagaata ataattatta agaagtagcc ttaacatatg     1890

agaaatttga aaggtgatta ttatgccatg ggcaatttct taacatttac agtttgtgtt     1950

tactccgtgt agaattagaa tactggcaaa aatcactggg gaaactactt agatggaaag     2010

catatcttat gcaggtaatc attatttgac taaattctat tgtttcaagg ctgctggcca     2070

cataggatgt ttttactatt tttttagcct aagtgcttac ataaaatggt gattctttta     2130

taattgtgca agttgataat attaattgag tcattcttgt cacatccaac taaaacagac     2190

tcaagaagct agggggaaaa agtacttggg acacataata ttgctccaag aatgtaattc     2250

tctgtgagcc tggctactga aactgcttgc tgtaacctga gaccagtttt gtctatagct     2310

gctgagataa cttgctgtaa ctctaggact aattttacct atggccattg cccaccagtt     2370

ggagcttgcc agctccccag ggctttacta ataccaatga actttctctt aagatcacaa     2430

gttggccggg cgtggtgact catacctgta atcccagcac tttgggaggc cgaggcgggt     2490

ggatcacaag gtcaggagat tgagaccatc ctggctaaca tggtaaaacc ccatctctac     2550

taaaaataca aaaattagcc gggcatggtg gtgggcgcct gtagtcccac ctactcggga     2610

ggctagaggc tgaggcagga gaatggcgtg aacccgggag gtggagcttg cagtgagcca     2670

agactgcact actgcactcc agcctgggtg acagagcgag actccgtctc aaaaaaaaaa     2730

aaaaaaaaaa aagaaagacc acaagtaaca ttcttagttt taaataaaac cctcaacctt     2790

ctctttgttt gttggacata ctaaagatca cctagaattg aaattctttc ttctcaaaac     2850

attaaattta gttttgtgtc tacattttca ttttgacttt gacatgcatg gtgtcagaag     2910

tgggatacaa agctgactca cctcatggag aatcattggc ctttggagtt atggcatgag     2970

gtacccatgt tggggccctt tgaaccccct acacccccac cactttcaca ggtaatcctt     3030

tctccctcca gtaagtatct cttggacaga actctcagat atggttcgag ttctgtttta     3090

tttgggatat gattagggag aggtctttcc ccctcttgtt tggtagatct gttgggtaga     3150

attattttcc ccctgttgac ctcagctgcg aggtttggac cttgaggctt ggatgaggga     3210

atttttccct ttctttggag aaggcttatc attcttactg gtaagcatgt attttatttt     3270

ctgtcctgtc ttgtatttat ttggcctttg tgtattcagt gcttgcattt acttggcttt     3330

tgcatagttg acattaaatc agagcaccca cgaaatgagc tctcaaagtt caaaggcatg     3390

ccagaatatt ttctggaact ccagctagta acatattcaa acattacagg gatcatttag     3450

tctgtttttc ttaaaactga actaaaagat ggaggctata aaatcataca ctccaaataa     3510

gatatgcata tttcattgat atcttgaggc taaaaaaaaa taaaaacaaa aacaaaacac     3570

attcaggata caaatattgc cttgttaaaa aatactgtct caaaggtggc tgaaactttc     3630

ttttctagac ctttcccctc cccttcttac agtatcccct ctttatcctt ctctaaacag     3690

ctattctaac atactactta aataaaaaca cttgaaaacc agcagatata aaacaaagtc     3750

attttgacct tcctactgtt ttttttttaa agcaaagatt aaattcccat gtaaaacctt     3810

cctccctata caaaaaagaa tagcagcatt tttatcttca atgacaaaga attgagtcca     3870

agaaaatact gtataaacct tgttaaaaat cactcttgtc ttttggtcct actcacataa     3930

ttcagcacac tttcacagtt aactattttt tgttcaattt agtgcactgg tgagtgactc     3990

aaactgcttt atcccaaatt tgatttacag cctttataag attgcctatt aaaaaagctt     4050

aaagcttatc cttagcccat tttgtcagaa aaataatttg catctaatca tttttataaa     4110

ctggtgaatt tacgtgtttt actatatcat gactaaaatt ctaaaataaa agttttaata     4170

tcttta                                                                4176


<210>  53
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Ser Val Leu Asn Val Lys Glu Ser Lys Ala Pro Glu Arg Thr 
1               5                   10                  15      


Val Val Val Ala Gly Leu Pro Val Asp Leu Phe Ser Asp Gln Leu Leu 
            20                  25                  30          


Ala Val Leu Val Lys Ser His Phe Gln Asp Ile Lys Asn Glu Gly Gly 
        35                  40                  45              


Asp Val Glu Asp Val Ile Tyr Pro Thr Arg Thr Lys Gly Val Ala Tyr 
    50                  55                  60                  


Val Ile Phe Lys Glu Lys Lys Val Ala Glu Asn Val Ile Arg Gln Lys 
65                  70                  75                  80  


Lys His Trp Leu Ala Arg Lys Thr Arg His Ala Glu Leu Thr Val Ser 
                85                  90                  95      


Leu Arg Val Ser His Phe Gly Asp Lys Ile Phe Ser Ser Val Asn Ala 
            100                 105                 110         


Ile Leu Asp Leu Ser Val Phe Gly Lys Glu Val Thr Leu Glu Thr Leu 
        115                 120                 125             


Val Lys Asp Leu Lys Lys Lys Ile Pro Ser Leu Ser Phe Ser Pro Leu 
    130                 135                 140                 


Lys Pro Asn Gly Arg Ile Ser Val Glu Gly Ser Phe Leu Ala Val Lys 
145                 150                 155                 160 


Arg Leu Arg Glu Ser Leu Leu Ala Arg Ala Cys Ser Leu Leu Glu Lys 
                165                 170                 175     


Asp Arg Asn Phe Thr Ser Glu Glu Arg Lys Trp Asn Arg Gln Asn Pro 
            180                 185                 190         


Gln Arg Asn Leu Gln Arg Ser Asn Asn Ser Leu Ala Ser Val Arg Thr 
        195                 200                 205             


Leu Val Pro Glu Thr Ala Arg Ser Gly Glu Met Leu Val Leu Asp Thr 
    210                 215                 220                 


Asp Val Phe Leu Tyr Leu Lys His Lys Cys Gly Ser Tyr Glu Ser Thr 
225                 230                 235                 240 


Leu Lys Lys Phe His Ile Leu Ser Gln Glu Lys Val Asp Gly Glu Ile 
                245                 250                 255     


Thr Thr Ile Cys Leu Lys Ser Ile Gln Val Gly Ser Gln Pro Asn Asn 
            260                 265                 270         


Ala Lys His Val Lys Glu Leu Ile Glu Glu Trp Ser His Ala Leu Tyr 
        275                 280                 285             


Leu Lys Leu Arg Lys Glu Thr Phe Ile Leu Glu Gly Lys Glu Asn Arg 
    290                 295                 300                 


Glu Lys Arg Met Ile Lys Arg Ala Cys Glu Gln Leu Ser Ser Arg Tyr 
305                 310                 315                 320 


Leu Glu Val Leu Ile Asn Leu Tyr Arg Thr His Ile Asp Ile Ile Gly 
                325                 330                 335     


Ser Ser Ser Asp Thr Tyr Leu Phe Lys Lys Gly Val Met Lys Leu Ile 
            340                 345                 350         


Gly Gln Lys Val Ser 
        355         


<210>  54
<211>  1638
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (269)..(1222)

<400>  54
attcaggtac caggtagccc caaggaggag ctgccgacct ggcagggaac aaccaagact       60

ggggttaaat ctcacagcct gcaagtggaa gagaagaact tgaacccagg tccaactttt      120

gcgccacagc aggctgcctc ttggtcctga caggaagtca caacttggcc ctgacttcct      180

atcctaggga aggggccggc tggagaggcc aggacagaga aagcagatcc cttctttttc      240

caaggactct gtgtcttcca taggcaac atg tca gaa ggg gtg ggc acg ttc         292
                               Met Ser Glu Gly Val Gly Thr Phe            
                               1               5                          

cgc atg gta cct gaa gag gaa cag gag ctc cgt gcc caa ctg gag cag        340
Arg Met Val Pro Glu Glu Glu Gln Glu Leu Arg Ala Gln Leu Glu Gln           
    10                  15                  20                            

ctc aca acc aag gac cat gga cct gtc ttt ggc ccg tgc agc cag ctg        388
Leu Thr Thr Lys Asp His Gly Pro Val Phe Gly Pro Cys Ser Gln Leu           
25                  30                  35                  40            

ccc cgc cac acc ttg cag aag gcc aag gat gag ctg aac gag aga gag        436
Pro Arg His Thr Leu Gln Lys Ala Lys Asp Glu Leu Asn Glu Arg Glu           
                45                  50                  55                

gag acc cgg gag gag gca gtg cga gag ctg cag gag atg gtg cag gcg        484
Glu Thr Arg Glu Glu Ala Val Arg Glu Leu Gln Glu Met Val Gln Ala           
            60                  65                  70                    

cag gcg gcc tcg ggg gag gag ctg gcg gtg gcc gtg gcg gag agg gtg        532
Gln Ala Ala Ser Gly Glu Glu Leu Ala Val Ala Val Ala Glu Arg Val           
        75                  80                  85                        

caa gag aag gac agc ggc ttc ttc ctg cgc ttc atc cgc gca cgg aag        580
Gln Glu Lys Asp Ser Gly Phe Phe Leu Arg Phe Ile Arg Ala Arg Lys           
    90                  95                  100                           

ttc aac gtg ggc cgt gcc tat gag ctg ctc aga ggc tat gtg aat ttc        628
Phe Asn Val Gly Arg Ala Tyr Glu Leu Leu Arg Gly Tyr Val Asn Phe           
105                 110                 115                 120           

cgg ctg cag tac cct gag ctc ttt gac agc ctg tcc cca gag gct gtc        676
Arg Leu Gln Tyr Pro Glu Leu Phe Asp Ser Leu Ser Pro Glu Ala Val           
                125                 130                 135               

cgc tgc acc att gaa gct ggc tac cct ggt gtc ctc tct agt cgg gac        724
Arg Cys Thr Ile Glu Ala Gly Tyr Pro Gly Val Leu Ser Ser Arg Asp           
            140                 145                 150                   

aag tat ggc cga gtg gtc atg ctc ttc aac att gag aac tgg caa agt        772
Lys Tyr Gly Arg Val Val Met Leu Phe Asn Ile Glu Asn Trp Gln Ser           
        155                 160                 165                       

caa gaa atc acc ttt gat gag atc ttg cag gca tat tgc ttc atc ctg        820
Gln Glu Ile Thr Phe Asp Glu Ile Leu Gln Ala Tyr Cys Phe Ile Leu           
    170                 175                 180                           

gag aag ctg ctg gag aat gag gaa act caa atc aat ggc ttc tgc atc        868
Glu Lys Leu Leu Glu Asn Glu Glu Thr Gln Ile Asn Gly Phe Cys Ile           
185                 190                 195                 200           

att gag aac ttc aag ggc ttt acc atg cag cag gct gct agt ctc cgg        916
Ile Glu Asn Phe Lys Gly Phe Thr Met Gln Gln Ala Ala Ser Leu Arg           
                205                 210                 215               

act tca gat ctc agg aag atg gtg gac atg ctc cag gat tcc ttc cca        964
Thr Ser Asp Leu Arg Lys Met Val Asp Met Leu Gln Asp Ser Phe Pro           
            220                 225                 230                   

gcc cgg ttc aaa gcc atc cac ttc atc cac cag cca tgg tac ttc acc       1012
Ala Arg Phe Lys Ala Ile His Phe Ile His Gln Pro Trp Tyr Phe Thr           
        235                 240                 245                       

acg acc tac aat gtg gtc aag ccc ttc ttg aag agc aag ctg ctt gag       1060
Thr Thr Tyr Asn Val Val Lys Pro Phe Leu Lys Ser Lys Leu Leu Glu           
    250                 255                 260                           

agg gtc ttt gtc cac ggg gat gac ctt tct ggt ttc tac cag gag atc       1108
Arg Val Phe Val His Gly Asp Asp Leu Ser Gly Phe Tyr Gln Glu Ile           
265                 270                 275                 280           

gat gag aac atc ctg ccc tct gac ttc ggg ggc acg ctg ccc aag tat       1156
Asp Glu Asn Ile Leu Pro Ser Asp Phe Gly Gly Thr Leu Pro Lys Tyr           
                285                 290                 295               

gat ggc aag gcc gtt gct gag cag ctc ttt ggc ccc cag gcc caa gct       1204
Asp Gly Lys Ala Val Ala Glu Gln Leu Phe Gly Pro Gln Ala Gln Ala           
            300                 305                 310                   

gag aac aca gcc ttc tga aaacatctcc tgccagctga actgtagtta              1252
Glu Asn Thr Ala Phe                                                       
        315                                                               

gaatctctgg gcctctcctc aactgtcctg gacccaaggc taggaaaggg ctgcttgaga     1312

tgactgtggt ccccccttag actccctaag cccgagtgag ctcaggtgtc accctgttct     1372

caagttgggg gatgggtaat aaaggagggg gaattccctt gaacaagaag aactggggat     1432

agttatattt ccacctgccc ttgaagcttt aagacagtga tttttgtgta aggttgtatt     1492

tcaaagactc gaattcattt tctcagtcat ttcctttgta acagagtttt acgacttaga     1552

gtctgtgaaa acaggcaagg agcccgggtt aaaatatccc cctattcgcc cccaaaatgc     1612

aataaaagaa gataaaagag agagga                                          1638


<210>  55
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ser Glu Gly Val Gly Thr Phe Arg Met Val Pro Glu Glu Glu Gln 
1               5                   10                  15      


Glu Leu Arg Ala Gln Leu Glu Gln Leu Thr Thr Lys Asp His Gly Pro 
            20                  25                  30          


Val Phe Gly Pro Cys Ser Gln Leu Pro Arg His Thr Leu Gln Lys Ala 
        35                  40                  45              


Lys Asp Glu Leu Asn Glu Arg Glu Glu Thr Arg Glu Glu Ala Val Arg 
    50                  55                  60                  


Glu Leu Gln Glu Met Val Gln Ala Gln Ala Ala Ser Gly Glu Glu Leu 
65                  70                  75                  80  


Ala Val Ala Val Ala Glu Arg Val Gln Glu Lys Asp Ser Gly Phe Phe 
                85                  90                  95      


Leu Arg Phe Ile Arg Ala Arg Lys Phe Asn Val Gly Arg Ala Tyr Glu 
            100                 105                 110         


Leu Leu Arg Gly Tyr Val Asn Phe Arg Leu Gln Tyr Pro Glu Leu Phe 
        115                 120                 125             


Asp Ser Leu Ser Pro Glu Ala Val Arg Cys Thr Ile Glu Ala Gly Tyr 
    130                 135                 140                 


Pro Gly Val Leu Ser Ser Arg Asp Lys Tyr Gly Arg Val Val Met Leu 
145                 150                 155                 160 


Phe Asn Ile Glu Asn Trp Gln Ser Gln Glu Ile Thr Phe Asp Glu Ile 
                165                 170                 175     


Leu Gln Ala Tyr Cys Phe Ile Leu Glu Lys Leu Leu Glu Asn Glu Glu 
            180                 185                 190         


Thr Gln Ile Asn Gly Phe Cys Ile Ile Glu Asn Phe Lys Gly Phe Thr 
        195                 200                 205             


Met Gln Gln Ala Ala Ser Leu Arg Thr Ser Asp Leu Arg Lys Met Val 
    210                 215                 220                 


Asp Met Leu Gln Asp Ser Phe Pro Ala Arg Phe Lys Ala Ile His Phe 
225                 230                 235                 240 


Ile His Gln Pro Trp Tyr Phe Thr Thr Thr Tyr Asn Val Val Lys Pro 
                245                 250                 255     


Phe Leu Lys Ser Lys Leu Leu Glu Arg Val Phe Val His Gly Asp Asp 
            260                 265                 270         


Leu Ser Gly Phe Tyr Gln Glu Ile Asp Glu Asn Ile Leu Pro Ser Asp 
        275                 280                 285             


Phe Gly Gly Thr Leu Pro Lys Tyr Asp Gly Lys Ala Val Ala Glu Gln 
    290                 295                 300                 


Leu Phe Gly Pro Gln Ala Gln Ala Glu Asn Thr Ala Phe 
305                 310                 315         


<210>  56
<211>  9563
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (343)..(1821)

<400>  56
gcactgaggc gctgcggcgg cggtggtggc ggtggcagcg gtggcggctg ctcgtcctag       60

cctggcgggg gcgggggtct ggaagatggg ggcgggtgga acaacgggcc ggtgaggagc      120

agccgccgcc gtctccgccg tcgctggggc agctgccgcg gtggtcgcct ctggcagtgc      180

cgctagcttt caggcagtcg cctctcctcc cgacatcccg ccttgaggag gctgaggcgg      240

aatcgcggct ggcggcgggg ggacggaccg gccctgcagt ggccgcagtg acagcccgga      300

cccggccctc cgcccgctct cgcctcggcg cccgcagcca cg atg aac cgg ggc         354
                                               Met Asn Arg Gly            
                                               1                          

ggc ggc agc ccg tcg gcc gcc gcc aac tac ctg ctc tgt acc aac tgc        402
Gly Gly Ser Pro Ser Ala Ala Ala Asn Tyr Leu Leu Cys Thr Asn Cys           
5                   10                  15                  20            

cgg aaa gtg ctg cgg aag gat aaa aga atc aga gtg tct caa ccc ttg        450
Arg Lys Val Leu Arg Lys Asp Lys Arg Ile Arg Val Ser Gln Pro Leu           
                25                  30                  35                

aca aga gga cca agt gcc ttt att cca gag aag gaa gtt gtc caa gca        498
Thr Arg Gly Pro Ser Ala Phe Ile Pro Glu Lys Glu Val Val Gln Ala           
            40                  45                  50                    

aac aca gtg gat gaa cgt act aac ttt ctt gtg gaa gaa tac tct aca        546
Asn Thr Val Asp Glu Arg Thr Asn Phe Leu Val Glu Glu Tyr Ser Thr           
        55                  60                  65                        

tcc ggt cgt ctg gac aac atc aca cag gtc atg agt tta cac act cag        594
Ser Gly Arg Leu Asp Asn Ile Thr Gln Val Met Ser Leu His Thr Gln           
    70                  75                  80                            

tac ctg gag tct ttc ttg cgg agc cag ttt tac atg ttg cgc atg gat        642
Tyr Leu Glu Ser Phe Leu Arg Ser Gln Phe Tyr Met Leu Arg Met Asp           
85                  90                  95                  100           

ggt ccc ctt cct cta cca tac agg cac tat att gca ata atg gct gca        690
Gly Pro Leu Pro Leu Pro Tyr Arg His Tyr Ile Ala Ile Met Ala Ala           
                105                 110                 115               

gct aga cat cag tgt tct tac tta ata aac atg cat gtg gat gaa ttt        738
Ala Arg His Gln Cys Ser Tyr Leu Ile Asn Met His Val Asp Glu Phe           
            120                 125                 130                   

tta aag act gga ggt att gct gag tgg ttg aat ggt ttg gaa tat gtg        786
Leu Lys Thr Gly Gly Ile Ala Glu Trp Leu Asn Gly Leu Glu Tyr Val           
        135                 140                 145                       

cca caa aga ctg aaa aat ctt aat gaa att aat aag ctg cta gca cat        834
Pro Gln Arg Leu Lys Asn Leu Asn Glu Ile Asn Lys Leu Leu Ala His           
    150                 155                 160                           

cga cct tgg ctg atc aca aaa gag cac att cag aaa ctt gtc aaa act        882
Arg Pro Trp Leu Ile Thr Lys Glu His Ile Gln Lys Leu Val Lys Thr           
165                 170                 175                 180           

gga gaa aat aat tgg tct ctg cct gaa ctg gta cat gct gtg gtc ctc        930
Gly Glu Asn Asn Trp Ser Leu Pro Glu Leu Val His Ala Val Val Leu           
                185                 190                 195               

ctg gca cat tat cat gct ttg gca agc ttt gtt ttt ggt agt ggt atc        978
Leu Ala His Tyr His Ala Leu Ala Ser Phe Val Phe Gly Ser Gly Ile           
            200                 205                 210                   

aat cca gag aga gat cca gaa atc tcc aat gga ttc agg cta ata tca       1026
Asn Pro Glu Arg Asp Pro Glu Ile Ser Asn Gly Phe Arg Leu Ile Ser           
        215                 220                 225                       

gtc aac aat ttc tgc gtt tgt gat ctt gct aat gac aac aac ata gag       1074
Val Asn Asn Phe Cys Val Cys Asp Leu Ala Asn Asp Asn Asn Ile Glu           
    230                 235                 240                           

aat gca tct ctt tca ggc agc aac ttt ggg att gtg gat tct cta agt       1122
Asn Ala Ser Leu Ser Gly Ser Asn Phe Gly Ile Val Asp Ser Leu Ser           
245                 250                 255                 260           

gag cta gag gcc tta atg gaa agg atg aaa aga ctt caa gaa gaa agg       1170
Glu Leu Glu Ala Leu Met Glu Arg Met Lys Arg Leu Gln Glu Glu Arg           
                265                 270                 275               

gaa gat gaa gag gcg tct caa gaa gaa atg agc act cgt ttt gaa aag       1218
Glu Asp Glu Glu Ala Ser Gln Glu Glu Met Ser Thr Arg Phe Glu Lys           
            280                 285                 290                   

gag aag aaa gaa agt ctt ttt gtg gtc tct gga gat act ttt cat tca       1266
Glu Lys Lys Glu Ser Leu Phe Val Val Ser Gly Asp Thr Phe His Ser           
        295                 300                 305                       

ttt cct cat tca gat ttt gag gat gac atg att ata aca tct gat gtc       1314
Phe Pro His Ser Asp Phe Glu Asp Asp Met Ile Ile Thr Ser Asp Val           
    310                 315                 320                           

tct cga tat att gaa gac cct ggt ttt ggg tat gaa gac ttt gcc aga       1362
Ser Arg Tyr Ile Glu Asp Pro Gly Phe Gly Tyr Glu Asp Phe Ala Arg           
325                 330                 335                 340           

cga gga gaa gag cat ttg cca aca ttc cga gct cag gac tat acc tgg       1410
Arg Gly Glu Glu His Leu Pro Thr Phe Arg Ala Gln Asp Tyr Thr Trp           
                345                 350                 355               

gaa aat cat ggg ttc tcc ctg gtg aac aga ctt tat tct gac att gga       1458
Glu Asn His Gly Phe Ser Leu Val Asn Arg Leu Tyr Ser Asp Ile Gly           
            360                 365                 370                   

cat ctt ctt gat gaa aag ttt cgg atg gtc tac aat ctc aca tat aac       1506
His Leu Leu Asp Glu Lys Phe Arg Met Val Tyr Asn Leu Thr Tyr Asn           
        375                 380                 385                       

act atg gcc acc cat gag gat gtt gac aca acc atg ctg cgc aga gct       1554
Thr Met Ala Thr His Glu Asp Val Asp Thr Thr Met Leu Arg Arg Ala           
    390                 395                 400                           

tta ttt aac tat gtt cac tgt atg ttt gga atc agg tat gat gac tat       1602
Leu Phe Asn Tyr Val His Cys Met Phe Gly Ile Arg Tyr Asp Asp Tyr           
405                 410                 415                 420           

gat tat gga gaa gtt aat caa tta ctt gaa aga agc ctg aag gtt tac       1650
Asp Tyr Gly Glu Val Asn Gln Leu Leu Glu Arg Ser Leu Lys Val Tyr           
                425                 430                 435               

att aag aca gtg acc tgc tat cct gag aga act aca aaa cgc atg tat       1698
Ile Lys Thr Val Thr Cys Tyr Pro Glu Arg Thr Thr Lys Arg Met Tyr           
            440                 445                 450                   

gat agt tac tgg cgg cag ttc aaa cac tca gaa aaa gtt cat gtc aat       1746
Asp Ser Tyr Trp Arg Gln Phe Lys His Ser Glu Lys Val His Val Asn           
        455                 460                 465                       

cta ctt tta atg gaa gca cga atg caa gct gaa ctt ctt tat gct ctt       1794
Leu Leu Leu Met Glu Ala Arg Met Gln Ala Glu Leu Leu Tyr Ala Leu           
    470                 475                 480                           

cgt gcc ata act cgg cat ttg acc tga agtatcaccc aaggaaaatg             1841
Arg Ala Ile Thr Arg His Leu Thr                                           
485                 490                                                   

tcatacatgt gtaaagacct ttcacataag ataaacattg aagctatttg tgatatagca     1901

tcaaaaatta ttcagttctc tagtgtcaaa gtttagccgt ttgttttttt ttttttgttt     1961

tttgcggctg taatgtgcaa tgatgtgttt tattttcctt gatgcttaac attactaaca     2021

attgcaaaaa taatactgag gagcactact ttgcattgtt tgtagttgga gttttggata     2081

ctgatcataa atcatgaatc tggcgtatta atgcttaact tcagcgcctt tgggttgtgt     2141

gtatgtgtat tttttctccc cccaccccgc cctttttttt ttaagaataa ggacaagtgc     2201

ttacaatctg ctcaagcaat tgtttttcag atattggaat tcagcaaaga gtgacctctc     2261

tggccattct aaaactttaa tgttgtgtcc taaatctggt ggaggaaaag catgcgctgt     2321

tgaaccaagc tgctcactgg acacatattt gtgtccccag gagattattt gtcaggcact     2381

gttttttatt tgtttgtttg ttcatttatt gttgttttac tgctattggc gataacatga     2441

aatgtgatac agctattgcc cataatttaa tgtgaaatta atcatgatga attctatagc     2501

atgctactga aatgccaaat tcagctattt tctttctctt ctaaaatgga agtttcagtt     2561

ttccatatca gatgtatata agtggaatta taacacaatc ctatcactga cagtaatcct     2621

cagtcacctt aaataatcag tgctcacagt gctgcttaca gttcatttag ttggcacata     2681

taaacctgta cccacacaag actgaccaaa aattttcttt gcacattttt cctttctcat     2741

agtttttttc tatatttcgt taagcaaagg aaggttaata tgcctatttt tcctgttagg     2801

cttttagaaa ttattttcca tgacttttgt tcttataata ggttagacag tttatttttc     2861

aaaggtaaaa attgtgtttc tatgcattaa tgtgattgaa ctacaaaaac agagtgcaat     2921

atgttcaaaa aatactcaac taaactttcc ccctgtcata tcactgcaaa agtgtccttt     2981

taaacagagc cataaagaaa tttttttcaa atttctttat tgcacaggct tttttcagtt     3041

ttacctttct gggattgaac aatgttcctt tcataatgcc aaagcattcc cttccccaga     3101

aaaatctcct tggacaactg gtttaaaaac gttattaagt cataggggag gaataagcgg     3161

ccaaaaagtc acatttttgc attggtttac gttgcttgat tagactatct tcagagagca     3221

cattatgtgt ttatagcttt aatttgtatt atgtcaatga accagtgaag tgcctaaaga     3281

gatgcttaca actatccagt aggacacaac tgcactgctt tttaaacact ttttggttag     3341

ttaagggtga cttgaattgt acacatacat gctaattttt gaaaacttat ccatttttca     3401

tagtaaataa tatagataaa attttctgtt agagttcccg caaatatttc attttagact     3461

tacttgtgat ataagattta acttttcttt tgtgaaagaa tcgtgaacta gtgtttcatg     3521

aaatcatttt cctcttccat ttatcatcct cctctggtac aatatattgg gttgctttct     3581

tttagatttt gttccagata ggaaaacaaa tatgactgta tacttattaa cataaggtag     3641

ttctgcattt ttggattcca ggatcctgtt tgaaatcttc catgtgagga aaaaattact     3701

aatattttta aagacagggt ggtttattta aagagattat tcagagaact tgtgccatat     3761

ctcgtctgtt ttattgcata tgccatatgt taacttttat tcaatattac attatgtaga     3821

tatgtaatac aaagaaaata tttaggagaa tggcaaaaca caaatggcaa cataaatgtc     3881

catttgactt acctaacttc acaactttca agttgaggat gtcatttatt cttgaatttg     3941

tttttttact agatgctttc aattaatagc cctatatttt tgtgcaggcg aactgtataa     4001

caggataaaa aatgatttgt atgtattgaa aaggaggaga aattctcaca gaacaccata     4061

tgagctttag accaaaaggg gaaacaaggt ttaagtaact aaaatggcca cttagtttgt     4121

gtttattttt ttccctggaa atgtaagtag ttggagttta ggctatggaa atattagtgc     4181

ctttaataga tctctttcct tgcaaagttt ctttttagct cagcattgat ctatcttatc     4241

aataggaaaa taagttgact tggaactata aacaaaaaca acaccatata tttatgaacc     4301

tcagtgaacc agcctagaaa aattgacttc tgcaggtgct aaagcaccta ctaatacgca     4361

gcatgcacag catttcaggt tgtgaatacc attttacaac gagtttgctg ttaactctct     4421

ttatccaatg caaacttgaa attctgatgc ggttttccag ggtggtattt tttcagagta     4481

ttgaatttac tatttagtaa tttatagtat agctttttat attaaaatgt gatattttta     4541

aaagagatat ctggttcaat tggtataatg acgtgattat gcaatatgct gatctacacc     4601

ttgcgctcac attgtgccaa acttaaatgt gcaagtgtac gtgagaaaag cacatgtgaa     4661

tgtgaattct ttaattcttt gcttattatg ttaaaattag tcttcatagt ccactgatgt     4721

gtatgcttga ataatgtcta tttactttgg aatttcaaga tttccagctt caatggtaat     4781

ttataatttc tcagatcacc ttaagaaata ttgagatact ctcccacctg aaaataatct     4841

gttctttaac ccacctgact atgggagtag ccaggcaggt gcctcactgg cttcttcaga     4901

cgaggcttcc tcaggtggat atatgactat taggggaaaa gaggcttttg agacagctta     4961

ttacctcctt cccctttttg aactaagtac attgtctcag tcccagtatg aatttgtccc     5021

atttggggta tttttaaaat aaaagatggc taacatggaa tctggggcat agccttggcc     5081

tttaattatg gttgtaagcc caaataatgg cagagaaaca cagggctgtt tttacaacag     5141

aaaactcaat ataagtttta tataagaatc ctataaaatt tgaaccagag ctcctattta     5201

gttgttataa tgtctcctaa agatcttaaa tgcttctaaa agctaattat tattccagag     5261

caactttttc cttttccccc ttataaagtt tttttttaaa tccaaaatct tagatttctg     5321

tgccacagca aaataaaatg atcaacaatt aaagatctgt acttaaaata gtacaccatt     5381

tttagtggag ggagggtgca tgcctatatg atggtaagat tcttttgaac tctaaggaca     5441

attcctcatg gaaaaaataa atttcagtgc atattataaa aatgatttgc actgtgttag     5501

caaaataagg tgttttaggt tgtattttaa agacaattct aaatcatttc tctggaaagc     5561

aagaccttaa attcttctct ttaatagaac tgcttttatg caaagagatg gtcttaacat     5621

ggactaaaca gtacataaca ataatgtttg ttatgtaaat agtatatcac atttgcttag     5681

tagcacaatt caacagcagg ctgaaagtcg tggctcctct gctcagattg agttttaagt     5741

tacctaattt atgtaatcag aatctattct aggtggccgt caacgtaaac tgtgtttccc     5801

tattatatcc ctctggagac tgagaatcaa attaaatagt ctttcttcaa agcagtactg     5861

taacatgaat gtatttatct cagtcaacag aacttatatg cccactgtat gtggagctta     5921

tttcaatgct aatttggctt agttagcaga cctagaatct gcccaggtga gacctagaac     5981

aaaaatagct ggggtgaaat ggataagaga ggtagaggta tatgtcaagg cagagcccta     6041

tgaggaagga agagttttca aagaatatga ggaacatagt gctgagagtg tggctgcctt     6101

cagcaccgta cacctaatct agagaaaata tttcccatgt gggaggtcct gtctgcattc     6161

agtccaccct tttctgcctg cttcttcctc caagtgcctc aacctctaca tgctcactct     6221

cctccccttc cctcagccca tcttggtcta agcagctttc acaatccaaa ccaaacatca     6281

ccagccaccc gctgataagt caccagcatt tactttcctg agttactttt tctccattca     6341

ttgagactat ggattcatcc caactccttc taaatccctc aaccatccag ctatattttg     6401

gctaaccttt gccctagaca ctctaccaga tgttaatgca gtatcaagtg taaattgtgt     6461

caccctattc tgttctaccc ttttccctgc tgccgaaata tcttgctctc ctctacctca     6521

tccccaaaga gcctataaat tcagagtatc caaccttttc atggattcac tcactgttgt     6581

tcagtaatac aacttccata ttttaaataa atcataaaag atttttgcct tctatcaaag     6641

taggaaactt tatatttata catgatacag aaattgaact atttctatcg ttcagaattt     6701

agcatataac aggattttaa agtgattgaa ttgccatcct aacttggatt tgtattaggt     6761

tatgaatgaa tactgttgtt agtccaagct atttgaatgt aaagttaaaa ttctccagca     6821

atccagaatg acttgtaacc cttcagtgga atgggaaatt tctggtatgc aaatagggtg     6881

gtgttccaga catttgtttt attggtggtg tttgggcctt gaaacacatt tctaatagaa     6941

tgacatatgg caaagggtat ttagatggtc ctatgggatc acagaagccc atatgattta     7001

aaatatagat aaaataacac aaaattgggt acataagggt ttaaccaggc tttcctgggt     7061

tagactaagc ctctaacctc tgttcctatc ctgttcttat gggaggaaaa aaaatgttcc     7121

atgggatgaa aagaaaatgc attgactttg tagtctttat tctcctagcc gcacttcggg     7181

tatatccaga aggaagagga aatgcaaaga ggaagaagat gtaatagttc ttctctccag     7241

ctaggtgcac ttgaggttgt tcataaatgt aaaattatgt caggtttcta acatgggaca     7301

ctgcacacag ttgtctgacc tgatgaacca tcccatttga aagtatagat tattattatt     7361

tcttgtagta tttggttgtt ttccatctca ttcatgaaca actcaacctg atagtagtat     7421

ccaataaatg cctttcaggg ctcaggaatg aattgacatc ctagttaaga aatgagactt     7481

aataatggag actgaatgag gcggtttgta ttaaattata tgccatgaag tgttcatttt     7541

agctttaacc taattatgac tgtaccacca tgaagtacag aatgaaaaat tatatatatg     7601

ggggggaaac agaatgaata tctgattctt ttgaatgctt gtggaaatct ttgagatcgt     7661

gcagggcata ccacaaaata gcctttagaa cagataccca attttacagt tcataggaca     7721

acatcaaaca ttagtaagtc taaataagat gaatagaatt tttgttatgt aaattttgct     7781

agaacagtct attttcttgc acccctcaag ttaacctctt aaaaaaatga atgtataatt     7841

tctaccgaaa gaatatcaga gagaatctct ctggcctata gtgttaaaat attgttcaca     7901

aatcctgatt agttaagtgc atacattatg aaacttacag aataaaactt attatacatc     7961

tctttcttaa attaatatct ttacacattt tcaactggct ccccaagtct gataaggaag     8021

gattaaaaga aaaaagaaat gtattagttg ggtggccaag gagtttcctt tgtaatgttg     8081

agagacttcc gctttctgaa tttcgctggt tctctaaggt aaaagagtta aatagtaccc     8141

ttgttcacca aggaaagtga tccaaactat atatctagtg cagatatttc ctttgcatta     8201

tttagtcttc tctggagaga aaatacagtt tccccttcct ctttctcttc acatttactc     8261

ttttcaaccc aaaataagag acatagaaag caaaccacag ccagtttggc atcttctcag     8321

tgctactagt ataggcacat acacatacac agtctcagca aggttataaa gaaccctgtc     8381

aggtccactt gcaacatggc cttgctactt ggattagctc ctttaagcct gaaaataact     8441

ttcctggtca tggaagaact ggacgcatct tttaacttat gaaatagaag ttgaacttga     8501

aaactctttt taaaaaatcc tggttttgca ggacagctac ataatgaatg tatatattaa     8561

gactgtagct gaattgcaca tgaaatcaga ttgccaactt cttgactttc aatgttagac     8621

atttatcctt aagttgtgag cgatatatgt agcatgctgt gaaatgtctg ttatagctct     8681

ttaattcatc agtattaata cagaattatc atttgcgttt cttggtactt tttattcaat     8741

gtaatcagaa gctgtgatgt tttgcctttg tagtcctgtg ctttgttact gtaatttttt     8801

tttttttttt acgaagcacg tgactggact aatgtaaggc agatgacgtg atctttaaga     8861

ctgctatata tatcagtctc ttactctata aggttttaaa ttagaataag cttttatcaa     8921

atagataatt gatgcaattt aggattcacg caagtttcag tgtcaaatgg cggtcttata     8981

gtttcaattc tgaaaatagc aaacttaata aacagccact ttaaacttgt tctggcaaac     9041

cagaccctgc tgtagatata gtctaaggta gttaaccata taagcctttt caactcttaa     9101

tgccctccac atgaatcagc agttaagaag gttctagaac ccatgaaagc ttttgtatgt     9161

attactaggt tttgtttttc ttatgtttgc tgattttaca gttctgacta aagctgacct     9221

aaatggatca gtttatgtgt aatattctag tgctttaatg actctttttt tctttggagg     9281

gagggtaaca ttatttggac agatgcagaa ggaactgtta gtgagtcaag acaaacacat     9341

ctgaaataaa ggaactgtgt attaacatgt taacaattca taactgcact ttttatgaca     9401

ttttgaaaat ctatttatag gtacagaaca atgggttttg ttaaactgta tcacatttat     9461

acttgcagaa atttatttca ttgttattag taggaatttt attggttcaa taaaattggc     9521

aaaactgaac accaatcatt tgcctacttt gtttatactg ga                        9563


<210>  57
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Asn Arg Gly Gly Gly Ser Pro Ser Ala Ala Ala Asn Tyr Leu Leu 
1               5                   10                  15      


Cys Thr Asn Cys Arg Lys Val Leu Arg Lys Asp Lys Arg Ile Arg Val 
            20                  25                  30          


Ser Gln Pro Leu Thr Arg Gly Pro Ser Ala Phe Ile Pro Glu Lys Glu 
        35                  40                  45              


Val Val Gln Ala Asn Thr Val Asp Glu Arg Thr Asn Phe Leu Val Glu 
    50                  55                  60                  


Glu Tyr Ser Thr Ser Gly Arg Leu Asp Asn Ile Thr Gln Val Met Ser 
65                  70                  75                  80  


Leu His Thr Gln Tyr Leu Glu Ser Phe Leu Arg Ser Gln Phe Tyr Met 
                85                  90                  95      


Leu Arg Met Asp Gly Pro Leu Pro Leu Pro Tyr Arg His Tyr Ile Ala 
            100                 105                 110         


Ile Met Ala Ala Ala Arg His Gln Cys Ser Tyr Leu Ile Asn Met His 
        115                 120                 125             


Val Asp Glu Phe Leu Lys Thr Gly Gly Ile Ala Glu Trp Leu Asn Gly 
    130                 135                 140                 


Leu Glu Tyr Val Pro Gln Arg Leu Lys Asn Leu Asn Glu Ile Asn Lys 
145                 150                 155                 160 


Leu Leu Ala His Arg Pro Trp Leu Ile Thr Lys Glu His Ile Gln Lys 
                165                 170                 175     


Leu Val Lys Thr Gly Glu Asn Asn Trp Ser Leu Pro Glu Leu Val His 
            180                 185                 190         


Ala Val Val Leu Leu Ala His Tyr His Ala Leu Ala Ser Phe Val Phe 
        195                 200                 205             


Gly Ser Gly Ile Asn Pro Glu Arg Asp Pro Glu Ile Ser Asn Gly Phe 
    210                 215                 220                 


Arg Leu Ile Ser Val Asn Asn Phe Cys Val Cys Asp Leu Ala Asn Asp 
225                 230                 235                 240 


Asn Asn Ile Glu Asn Ala Ser Leu Ser Gly Ser Asn Phe Gly Ile Val 
                245                 250                 255     


Asp Ser Leu Ser Glu Leu Glu Ala Leu Met Glu Arg Met Lys Arg Leu 
            260                 265                 270         


Gln Glu Glu Arg Glu Asp Glu Glu Ala Ser Gln Glu Glu Met Ser Thr 
        275                 280                 285             


Arg Phe Glu Lys Glu Lys Lys Glu Ser Leu Phe Val Val Ser Gly Asp 
    290                 295                 300                 


Thr Phe His Ser Phe Pro His Ser Asp Phe Glu Asp Asp Met Ile Ile 
305                 310                 315                 320 


Thr Ser Asp Val Ser Arg Tyr Ile Glu Asp Pro Gly Phe Gly Tyr Glu 
                325                 330                 335     


Asp Phe Ala Arg Arg Gly Glu Glu His Leu Pro Thr Phe Arg Ala Gln 
            340                 345                 350         


Asp Tyr Thr Trp Glu Asn His Gly Phe Ser Leu Val Asn Arg Leu Tyr 
        355                 360                 365             


Ser Asp Ile Gly His Leu Leu Asp Glu Lys Phe Arg Met Val Tyr Asn 
    370                 375                 380                 


Leu Thr Tyr Asn Thr Met Ala Thr His Glu Asp Val Asp Thr Thr Met 
385                 390                 395                 400 


Leu Arg Arg Ala Leu Phe Asn Tyr Val His Cys Met Phe Gly Ile Arg 
                405                 410                 415     


Tyr Asp Asp Tyr Asp Tyr Gly Glu Val Asn Gln Leu Leu Glu Arg Ser 
            420                 425                 430         


Leu Lys Val Tyr Ile Lys Thr Val Thr Cys Tyr Pro Glu Arg Thr Thr 
        435                 440                 445             


Lys Arg Met Tyr Asp Ser Tyr Trp Arg Gln Phe Lys His Ser Glu Lys 
    450                 455                 460                 


Val His Val Asn Leu Leu Leu Met Glu Ala Arg Met Gln Ala Glu Leu 
465                 470                 475                 480 


Leu Tyr Ala Leu Arg Ala Ile Thr Arg His Leu Thr 
                485                 490         


<210>  58
<211>  4672
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (48)..(1064)

<400>  58
ctccctgccc acctcctgca gcctcctgcg ccccgccgag ctggcgg atg gag ctg         56
                                                    Met Glu Leu           
                                                    1                     

cgc agc ggg agc gtg ggc agc cag gcg gtg gcg cgg agg atg gat ggg        104
Arg Ser Gly Ser Val Gly Ser Gln Ala Val Ala Arg Arg Met Asp Gly           
    5                   10                  15                            

gac agc cga gat ggc ggc ggc ggc aag gac gcc acc ggg tcg gag gac        152
Asp Ser Arg Asp Gly Gly Gly Gly Lys Asp Ala Thr Gly Ser Glu Asp           
20                  25                  30                  35            

tac gag aac ctg ccg act agc gcc tcc gtg tcc acc cac atg aca gca        200
Tyr Glu Asn Leu Pro Thr Ser Ala Ser Val Ser Thr His Met Thr Ala           
                40                  45                  50                

gga gcg atg gcc ggg atc ctg gag cac tcg gtc atg tac ccg gtg gac        248
Gly Ala Met Ala Gly Ile Leu Glu His Ser Val Met Tyr Pro Val Asp           
            55                  60                  65                    

tcg gtg aag aca cga atg cag agt ttg agt cca gat ccc aaa gcc cag        296
Ser Val Lys Thr Arg Met Gln Ser Leu Ser Pro Asp Pro Lys Ala Gln           
        70                  75                  80                        

tac aca agt atc tac gga gcc ctc aag aaa atc atg cgg acc gaa ggc        344
Tyr Thr Ser Ile Tyr Gly Ala Leu Lys Lys Ile Met Arg Thr Glu Gly           
    85                  90                  95                            

ttc tgg agg ccc ttg cga ggc gtc aac gtc atg atc atg ggt gca ggg        392
Phe Trp Arg Pro Leu Arg Gly Val Asn Val Met Ile Met Gly Ala Gly           
100                 105                 110                 115           

ccg gcc cat gcc atg tat ttt gcc tgc tat gaa aac atg aaa agg act        440
Pro Ala His Ala Met Tyr Phe Ala Cys Tyr Glu Asn Met Lys Arg Thr           
                120                 125                 130               

tta aat gac gtt ttc cac cac caa gga aac agc cac cta gcc aac ggg        488
Leu Asn Asp Val Phe His His Gln Gly Asn Ser His Leu Ala Asn Gly           
            135                 140                 145                   

ata gct ggg agt atg gcc acc ctg ctc cac gat gcg gta atg aat cca        536
Ile Ala Gly Ser Met Ala Thr Leu Leu His Asp Ala Val Met Asn Pro           
        150                 155                 160                       

gca gaa gtg gtg aag cag cgc ttg cag atg tac aac tcg cag cac cgg        584
Ala Glu Val Val Lys Gln Arg Leu Gln Met Tyr Asn Ser Gln His Arg           
    165                 170                 175                           

tca gca atc agc tgc atc cgg acg gtg tgg agg acc gag ggg ttg ggg        632
Ser Ala Ile Ser Cys Ile Arg Thr Val Trp Arg Thr Glu Gly Leu Gly           
180                 185                 190                 195           

gcc ttc tac cgg agc tac acc acg cag ctg acc atg aac atc ccc ttc        680
Ala Phe Tyr Arg Ser Tyr Thr Thr Gln Leu Thr Met Asn Ile Pro Phe           
                200                 205                 210               

cag tcc atc cac ttc atc acc tat gag ttc ctg cag gag cag gtc aac        728
Gln Ser Ile His Phe Ile Thr Tyr Glu Phe Leu Gln Glu Gln Val Asn           
            215                 220                 225                   

ccc cac cgg acc tac aac ccg cag tcc cac atc atc tca ggc ggg ctg        776
Pro His Arg Thr Tyr Asn Pro Gln Ser His Ile Ile Ser Gly Gly Leu           
        230                 235                 240                       

gcc ggg gcc ctc gcc gcg gcc gcc acg acc ccc ctg gac gtc tgt aag        824
Ala Gly Ala Leu Ala Ala Ala Ala Thr Thr Pro Leu Asp Val Cys Lys           
    245                 250                 255                           

acc ctt ctg aac act cag gag aac gtg gcc ctc tcg ctg gcc aac atc        872
Thr Leu Leu Asn Thr Gln Glu Asn Val Ala Leu Ser Leu Ala Asn Ile           
260                 265                 270                 275           

agc ggc cgg ctg tcg ggt atg gcc aat gcc ttc cgg acg gtg tac cag        920
Ser Gly Arg Leu Ser Gly Met Ala Asn Ala Phe Arg Thr Val Tyr Gln           
                280                 285                 290               

ctc aac ggc ctg gcc ggc tac ttc aaa ggc atc cag gcg cgt gtc atc        968
Leu Asn Gly Leu Ala Gly Tyr Phe Lys Gly Ile Gln Ala Arg Val Ile           
            295                 300                 305                   

tac cag atg ccc tcc acc gcc att tct tgg tct gtc tat gag ttc ttc       1016
Tyr Gln Met Pro Ser Thr Ala Ile Ser Trp Ser Val Tyr Glu Phe Phe           
        310                 315                 320                       

aag tac ttt ctc acc aag cgc cag ctg gaa aat cga gct cca tac taa       1064
Lys Tyr Phe Leu Thr Lys Arg Gln Leu Glu Asn Arg Ala Pro Tyr               
    325                 330                 335                           

aggaagggat catagaatct tttcttaaag tcattctctg cctgcatcca gccccttgcc     1124

ctctcctcac acgtagatca tttttttttt gcagggtgct gcctatgggc cctctgctcc     1184

ccaatgcctt agagagagga ggggacggca cggccgctca ccggaaggct gtgtgcgggg     1244

acatccgagg tggtggtgga caggaaggac ttgggaaggg gagcgagaaa ttgctttttc     1304

tcttcctccc tgggcagaat gtagcttttc tgcttcactg tggcagcctc ctccctggat     1364

ccttagatcc cagaggaggg aagaaaattt gcagtgactg aaaacagtaa aaaaaaaaaa     1424

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaatttatgt atataaaagt tgcattacac     1484

agtacaaaat agatggataa tgtttatcct ttatttttct atgtagaagt ttttgaattt     1544

gtgtgtgtgc ttgtgcgtgt ctacacctag tattacggct gggactctcc agctgttttt     1604

gttgttgtta tgtttttaag agggttgaat tcttccatca ggtgaacgaa aaaggcaaca     1664

aagtaataaa tcagtgaatg tggccggcag ctgtgtttag cccctccaga tggaagtttc     1724

acttgaatgt aaaataataa agtttatatt ttgaatttct cttttcatgg gggaaaaaag     1784

gtacgttaaa aaaatcaaaa taatgatatg tcacttgcag ctaccttttt ttttctttta     1844

aattcaatca gccaccttca tgtgcctttt tcctttgtct ttccccaaaa ttccaggacc     1904

agagatctgg ccctggccta ttttctcttg ctgtgtacac acacgcacac atgctgggtg     1964

gcaggatctc gcccgctgga gggtggtgga gcccagtaga attggggtga ctgggcataa     2024

acctgctgag actgcttcct tccctggttg tgagtgatgt gaatgcctgc cttccccggt     2084

cagcacttag aagcccttga taggcagcat ttggcgactt gtggggcagg tgtttgggat     2144

aaatcctacc ttcatcctag gacttatttc tgcatcagcc ttttaactca ggcacttcag     2204

gtaacgtgat ctatgtgtgt tttgactgaa tctcatctcc tgtgtttccc tgtgcagtct     2264

agggaagcat gtctccagtc tttgtccctg tcttgtccca accattaatt ctcatgtcac     2324

agcttctcac tgcatgtgac aagagccagg cctatctgct agggccctgc ggctgaggtc     2384

tgacctggac cctcatgccc gagtcggaag acccctctcc agaagccatt ctgcatcctt     2444

gtctgctctg cgtcacccga gaacacaggc ttcgcagcct cgctttctga aatggtgtgt     2504

gccgagtcag attgccgctc agagaaaata caagcccgtt ttccctagct gtgccatttg     2564

gtgctctgcc aggctgccgt gcaagggaat accgacgaga cgagctgcac tgtctctgat     2624

ttggagccct caccggagct tgtctttaaa aatgagcagg aagctcatgt atgtttgcat     2684

ttcagtgagc cgggtcctga cctgccgcca cccatcacgg tcagcgtggt gcatcttacc     2744

gaggaggcgc aggcctggat tcttttgagt ggtgctactg cctaggaagt aacacgtgga     2804

gaatttccat cttgggacca tgcacacagt gccttgggga gtagattttg ccctaatagc     2864

gatgaagaat tttatcagtc agtggagttc ctttttcaga tcagggatgg gaaagagcca     2924

aactgggtac ctcccacgtg tgccccgtga acagcccttt gcagctgggc tgtggggctt     2984

ggctgctgcc ctgtcccatc tggcagttaa cgccttctcc ctgctctgcc ccccactccc     3044

caaaaccagt tgcagcctca acccacatgg ggatgtagaa agccgtaaag tccacgctac     3104

tgttgaaaat gtttacatct ccgctctcaa cctgccttgg gttcgtgtta aatggtgtta     3164

aattctgcaa atggagggga aaaaaatcaa attctaaatt tcaaagtaga atttaaagca     3224

aatttgtaaa aaaattatcc taccacccct tttggtccac ttaagatatg ccacgctgaa     3284

gcaaggtatt tcctactgga ttttgctttc actggtgttt agaaaataaa cttgatttct     3344

ctaggagcac tcctttggtt agagggatgc aagaaggaga ggtgaaggtg gcgtgtggtg     3404

gctcatgcct gtaatcccag cactttgggg aggccgaggc aggcggatca cttgaggcca     3464

gcagtttgag accagcctgg ccaacatgat gaaaccccat ctctactaaa aatacaaaaa     3524

attagctggg catggtggca ggcacctgta atcccagtta cttgggaggc tgaggcagga     3584

gaattgcttg aacccaggag gtggaggttg cagtgagctg agattgtgcc actgcacttc     3644

agcctgggcg acagagtgac tctgtcaaaa aggaaaggca aaaaccggac cctggagctc     3704

tgtgggccct gattgcaggc ccctccctgt gtgatgaggg atgagtcagc ttggggagcc     3764

acttggccag cctgcatgcc tggtcatcag gaggttgaga aaagccttga aagttgtgaa     3824

gcactgagca gatacaagtg tttgttaatt ttgtagaaat taactttccc atctggcctt     3884

tatctccaaa gttggtattg ttgctccacg cagactgcag tccggtttct tattgtgact     3944

ttgacaatgc aaagtgcaaa ataggaagag gcctccccac cccactatcc caccctggtg     4004

accaattcag tgtaaccttt gcacgtactc agtcattggt gtctttggag tgacatctgc     4064

agccagttag tgccacctga gtacagcact cgtactttta catgatgtgt gtgtgagtag     4124

ctcttctgtc caaaccatga tttgaggttc aactacctgt agatcaaagc tttattttag     4184

aacgataaac tgattttttc caaatgggtg aaatcttctc cccatgacta tgttttctta     4244

actttgcatt gaatctattt actgggttac attctatgtg tagtttgctt tcttcatttt     4304

tttttctttt aaaatgctca tgtcttattc caagcacctt cctccaaagt ccccataaag     4364

ctgcatctcc aacacattgt tatgccaata aggttttatt taactttatt taaggatgat     4424

tgtgtctttg aatgacaaat gtactgctgc ttcctacctg caagacgaac aatgtatgtt     4484

tcaagggtga gcaagtgtta tttcttaaat ttctcaaatg cctgtagtaa ctattgtttc     4544

tgcctctcaa ttgttgccag ctctttgaag aaggggagaa ttgtgtgttt ttgtgtgggg     4604

atgtttctga tatgctgcta cagttgcaaa acactggagc tagagaaaat aaagtactga     4664

tcttcgaa                                                              4672


<210>  59
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Glu Leu Arg Ser Gly Ser Val Gly Ser Gln Ala Val Ala Arg Arg 
1               5                   10                  15      


Met Asp Gly Asp Ser Arg Asp Gly Gly Gly Gly Lys Asp Ala Thr Gly 
            20                  25                  30          


Ser Glu Asp Tyr Glu Asn Leu Pro Thr Ser Ala Ser Val Ser Thr His 
        35                  40                  45              


Met Thr Ala Gly Ala Met Ala Gly Ile Leu Glu His Ser Val Met Tyr 
    50                  55                  60                  


Pro Val Asp Ser Val Lys Thr Arg Met Gln Ser Leu Ser Pro Asp Pro 
65                  70                  75                  80  


Lys Ala Gln Tyr Thr Ser Ile Tyr Gly Ala Leu Lys Lys Ile Met Arg 
                85                  90                  95      


Thr Glu Gly Phe Trp Arg Pro Leu Arg Gly Val Asn Val Met Ile Met 
            100                 105                 110         


Gly Ala Gly Pro Ala His Ala Met Tyr Phe Ala Cys Tyr Glu Asn Met 
        115                 120                 125             


Lys Arg Thr Leu Asn Asp Val Phe His His Gln Gly Asn Ser His Leu 
    130                 135                 140                 


Ala Asn Gly Ile Ala Gly Ser Met Ala Thr Leu Leu His Asp Ala Val 
145                 150                 155                 160 


Met Asn Pro Ala Glu Val Val Lys Gln Arg Leu Gln Met Tyr Asn Ser 
                165                 170                 175     


Gln His Arg Ser Ala Ile Ser Cys Ile Arg Thr Val Trp Arg Thr Glu 
            180                 185                 190         


Gly Leu Gly Ala Phe Tyr Arg Ser Tyr Thr Thr Gln Leu Thr Met Asn 
        195                 200                 205             


Ile Pro Phe Gln Ser Ile His Phe Ile Thr Tyr Glu Phe Leu Gln Glu 
    210                 215                 220                 


Gln Val Asn Pro His Arg Thr Tyr Asn Pro Gln Ser His Ile Ile Ser 
225                 230                 235                 240 


Gly Gly Leu Ala Gly Ala Leu Ala Ala Ala Ala Thr Thr Pro Leu Asp 
                245                 250                 255     


Val Cys Lys Thr Leu Leu Asn Thr Gln Glu Asn Val Ala Leu Ser Leu 
            260                 265                 270         


Ala Asn Ile Ser Gly Arg Leu Ser Gly Met Ala Asn Ala Phe Arg Thr 
        275                 280                 285             


Val Tyr Gln Leu Asn Gly Leu Ala Gly Tyr Phe Lys Gly Ile Gln Ala 
    290                 295                 300                 


Arg Val Ile Tyr Gln Met Pro Ser Thr Ala Ile Ser Trp Ser Val Tyr 
305                 310                 315                 320 


Glu Phe Phe Lys Tyr Phe Leu Thr Lys Arg Gln Leu Glu Asn Arg Ala 
                325                 330                 335     


Pro Tyr 
        


<210>  60
<211>  4944
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (128)..(2170)

<400>  60
ctatgtctga tagcatttga ccctattgct tttagcctcc cggctttata tctatatata       60

cacaggtata tgtgtatatt ttatataatt gttctccgtt cgttgatatc aaagacagtt      120

gaaggaa atg aat ttt gaa act tca cgg tgt gcc acc cta cag tac tgc        169
        Met Asn Phe Glu Thr Ser Arg Cys Ala Thr Leu Gln Tyr Cys           
        1               5                   10                            

cct gac cct tac atc cag cgt ttc gta gaa acc cca gct cat ttc tct        217
Pro Asp Pro Tyr Ile Gln Arg Phe Val Glu Thr Pro Ala His Phe Ser           
15                  20                  25                  30            

tgg aaa gaa agt tat tac cga tcc acc atg tcc cag agc aca cag aca        265
Trp Lys Glu Ser Tyr Tyr Arg Ser Thr Met Ser Gln Ser Thr Gln Thr           
                35                  40                  45                

aat gaa ttc ctc agt cca gag gtt ttc cag cat atc tgg gat ttt ctg        313
Asn Glu Phe Leu Ser Pro Glu Val Phe Gln His Ile Trp Asp Phe Leu           
            50                  55                  60                    

gaa cag cct ata tgt tca gtt cag ccc att gac ttg aac ttt gtg gat        361
Glu Gln Pro Ile Cys Ser Val Gln Pro Ile Asp Leu Asn Phe Val Asp           
        65                  70                  75                        

gaa cca tca gaa gat ggt gcg aca aac aag att gag att agc atg gac        409
Glu Pro Ser Glu Asp Gly Ala Thr Asn Lys Ile Glu Ile Ser Met Asp           
    80                  85                  90                            

tgt atc cgc atg cag gac tcg gac ctg agt gac ccc atg tgg cca cag        457
Cys Ile Arg Met Gln Asp Ser Asp Leu Ser Asp Pro Met Trp Pro Gln           
95                  100                 105                 110           

tac acg aac ctg ggg ctc ctg aac agc atg gac cag cag att cag aac        505
Tyr Thr Asn Leu Gly Leu Leu Asn Ser Met Asp Gln Gln Ile Gln Asn           
                115                 120                 125               

ggc tcc tcg tcc acc agt ccc tat aac aca gac cac gcg cag aac agc        553
Gly Ser Ser Ser Thr Ser Pro Tyr Asn Thr Asp His Ala Gln Asn Ser           
            130                 135                 140                   

gtc acg gcg ccc tcg ccc tac gca cag ccc agc tcc acc ttc gat gct        601
Val Thr Ala Pro Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Ala           
        145                 150                 155                       

ctc tct cca tca ccc gcc atc ccc tcc aac acc gac tac cca ggc ccg        649
Leu Ser Pro Ser Pro Ala Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro           
    160                 165                 170                           

cac agt ttc gac gtg tcc ttc cag cag tcg agc acc gcc aag tcg gcc        697
His Ser Phe Asp Val Ser Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala           
175                 180                 185                 190           

acc tgg acg tat tcc act gaa ctg aag aaa ctc tac tgc caa att gca        745
Thr Trp Thr Tyr Ser Thr Glu Leu Lys Lys Leu Tyr Cys Gln Ile Ala           
                195                 200                 205               

aag aca tgc ccc atc cag atc aag gtg atg acc cca cct cct cag gga        793
Lys Thr Cys Pro Ile Gln Ile Lys Val Met Thr Pro Pro Pro Gln Gly           
            210                 215                 220                   

gct gtt atc cgc gcc atg cct gtc tac aaa aaa gct gag cac gtc acg        841
Ala Val Ile Arg Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr           
        225                 230                 235                       

gag gtg gtg aag cgg tgc ccc aac cat gag ctg agc cgt gaa ttc aac        889
Glu Val Val Lys Arg Cys Pro Asn His Glu Leu Ser Arg Glu Phe Asn           
    240                 245                 250                           

gag gga cag att gcc cct cct agt cat ttg att cga gta gag ggg aac        937
Glu Gly Gln Ile Ala Pro Pro Ser His Leu Ile Arg Val Glu Gly Asn           
255                 260                 265                 270           

agc cat gcc cag tat gta gaa gat ccc atc aca gga aga cag agt gtg        985
Ser His Ala Gln Tyr Val Glu Asp Pro Ile Thr Gly Arg Gln Ser Val           
                275                 280                 285               

ctg gta cct tat gag cca ccc cag gtt ggc act gaa ttc acg aca gtc       1033
Leu Val Pro Tyr Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Val           
            290                 295                 300                   

ttg tac aat ttc atg tgt aac agc agt tgt gtt gga ggg atg aac cgc       1081
Leu Tyr Asn Phe Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg           
        305                 310                 315                       

cgt cca att tta atc att gtt act ctg gaa acc aga gat ggg caa gtc       1129
Arg Pro Ile Leu Ile Ile Val Thr Leu Glu Thr Arg Asp Gly Gln Val           
    320                 325                 330                           

ctg ggc cga cgc tgc ttt gag gcc cgg atc tgt gct tgc cca gga aga       1177
Leu Gly Arg Arg Cys Phe Glu Ala Arg Ile Cys Ala Cys Pro Gly Arg           
335                 340                 345                 350           

gac agg aag gcg gat gaa gat agc atc aga aag cag caa gtt tcg gac       1225
Asp Arg Lys Ala Asp Glu Asp Ser Ile Arg Lys Gln Gln Val Ser Asp           
                355                 360                 365               

agt aca aag aac ggt gat ggt acg aag cgc ccg ttt cgt cag aac aca       1273
Ser Thr Lys Asn Gly Asp Gly Thr Lys Arg Pro Phe Arg Gln Asn Thr           
            370                 375                 380                   

cat ggt atc cag atg aca tcc atc aag aaa cga aga tcc cca gat gat       1321
His Gly Ile Gln Met Thr Ser Ile Lys Lys Arg Arg Ser Pro Asp Asp           
        385                 390                 395                       

gaa ctg tta tac tta cca gtg agg ggc cgt gag act tat gaa atg ctg       1369
Glu Leu Leu Tyr Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu           
    400                 405                 410                           

ttg aag atc aaa gag tcc ctg gaa ctc atg cag tac ctt cct cag cac       1417
Leu Lys Ile Lys Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His           
415                 420                 425                 430           

aca att gaa acg tac agg caa cag caa cag cag cag cac cag cac tta       1465
Thr Ile Glu Thr Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu           
                435                 440                 445               

ctt cag aaa cag acc tca ata cag tct cca tct tca tat ggt aac agc       1513
Leu Gln Lys Gln Thr Ser Ile Gln Ser Pro Ser Ser Tyr Gly Asn Ser           
            450                 455                 460                   

tcc cca cct ctg aac aaa atg aac agc atg aac aag ctg cct tct gtg       1561
Ser Pro Pro Leu Asn Lys Met Asn Ser Met Asn Lys Leu Pro Ser Val           
        465                 470                 475                       

agc cag ctt atc aac cct cag cag cgc aac gcc ctc act cct aca acc       1609
Ser Gln Leu Ile Asn Pro Gln Gln Arg Asn Ala Leu Thr Pro Thr Thr           
    480                 485                 490                           

att cct gat ggc atg gga gcc aac att ccc atg atg ggc acc cac atg       1657
Ile Pro Asp Gly Met Gly Ala Asn Ile Pro Met Met Gly Thr His Met           
495                 500                 505                 510           

cca atg gct gga gac atg aat gga ctc agc ccc acc cag gca ctc cct       1705
Pro Met Ala Gly Asp Met Asn Gly Leu Ser Pro Thr Gln Ala Leu Pro           
                515                 520                 525               

ccc cca ctc tcc atg cca tcc acc tcc cac tgc aca ccc cca cct ccg       1753
Pro Pro Leu Ser Met Pro Ser Thr Ser His Cys Thr Pro Pro Pro Pro           
            530                 535                 540                   

tat ccc aca gat tgc agc att gtc agt ttc tta gcg agg ttg ggc tgt       1801
Tyr Pro Thr Asp Cys Ser Ile Val Ser Phe Leu Ala Arg Leu Gly Cys           
        545                 550                 555                       

tca tca tgt ctg gac tat ttc acg acc cag ggg ctg acc acc atc tat       1849
Ser Ser Cys Leu Asp Tyr Phe Thr Thr Gln Gly Leu Thr Thr Ile Tyr           
    560                 565                 570                           

cag att gag cat tac tcc atg gat gat ctg gca agt ctg aaa atc cct       1897
Gln Ile Glu His Tyr Ser Met Asp Asp Leu Ala Ser Leu Lys Ile Pro           
575                 580                 585                 590           

gag caa ttt cga cat gcg atc tgg aag ggc atc ctg gac cac cgg cag       1945
Glu Gln Phe Arg His Ala Ile Trp Lys Gly Ile Leu Asp His Arg Gln           
                595                 600                 605               

ctc cac gaa ttc tcc tcc cct tct cat ctc ctg cgg acc cca agc agt       1993
Leu His Glu Phe Ser Ser Pro Ser His Leu Leu Arg Thr Pro Ser Ser           
            610                 615                 620                   

gcc tct aca gtc agt gtg ggc tcc agt gag acc cgg ggt gag cgt gtt       2041
Ala Ser Thr Val Ser Val Gly Ser Ser Glu Thr Arg Gly Glu Arg Val           
        625                 630                 635                       

att gat gct gtg cga ttc acc ctc cgc cag acc atc tct ttc cca ccc       2089
Ile Asp Ala Val Arg Phe Thr Leu Arg Gln Thr Ile Ser Phe Pro Pro           
    640                 645                 650                           

cga gat gag tgg aat gac ttc aac ttt gac atg gat gct cgc cgc aat       2137
Arg Asp Glu Trp Asn Asp Phe Asn Phe Asp Met Asp Ala Arg Arg Asn           
655                 660                 665                 670           

aag caa cag cgc atc aaa gag gag ggg gag tga gcctcaccat gtgagctctt     2190
Lys Gln Gln Arg Ile Lys Glu Glu Gly Glu                                   
                675                 680                                   

cctatccctc tcctaactgc cagcccccta aaagcactcc tgcttaatct tcaaagcctt     2250

ctccctagct cctccccttc ctcttgtctg atttcttagg ggaaggagaa gtaagaggct     2310

acctcttacc taacatctga cctggcatct aattctgatt ctggctttaa gccttcaaaa     2370

ctatagcttg cagaactgta gctgccatgg ctaggtagaa gtgagcaaaa aagagttggg     2430

tgtctcctta agctgcagag atttctcatt gacttttata aagcatgttc acccttatag     2490

tctaagacta tatatataaa tgtataaata tacagtatag atttttgggt ggggggcatt     2550

gagtattgtt taaaatgtaa tttaaatgaa agaaaattga gttgcactta ttgaccattt     2610

tttaatttac ttgttttgga tggcttgtct atactccttc ccttaagggg tatcatgtat     2670

ggtgataggt atctagagct taatgctaca tgtgagtgac gatgatgtac agattctttc     2730

agttctttgg attctaaata catgccacat caaacctttg agtagatcca tttccattgc     2790

ttattatgta ggtaagactg tagatatgta ttcttttctc agtgttggta tattttatat     2850

tactgacatt tcttctagtg atgatggttc acgttggggt gatttaatcc agttataaga     2910

agaagttcat gtccaaacgt cctctttagt ttttggttgg gaatgaggaa aattcttaaa     2970

aggcccatag cagccagttc aaaaacaccc gacgtcatgt atttgagcat atcagtaacc     3030

cccttaaatt taataccaga taccttatct tacaatattg attgggaaaa catttgctgc     3090

cattacagag gtattaaaac taaatttcac tactagattg actaactcaa atacacattt     3150

gctactgttg taagaattct gattgatttg attgggatga atgccatcta tctagttcta     3210

acagtgaagt tttactgtct attaatattc agggtaaata ggaatcattc agaaatgttg     3270

agtctgtact aaacagtaag atatctcaat gaaccataaa ttcaactttg taaaaatctt     3330

ttgaagcata gataatattg tttggtaaat gtttcttttg tttggtaaat gtttctttta     3390

aagaccctcc tattctataa aactctgcat gtagaggctt gtttaccttt ctctctctaa     3450

ggtttacaat aggagtggtg atttgaaaaa tataaaatta tgagattggt tttcctgtgg     3510

cataaattgc atcactgtat cattttcttt tttaaccggt aagagtttca gtttgttgga     3570

aagtaactgt gagaacccag tttcccgtcc atctccctta gggactaccc atagacatga     3630

aaggtcccca cagagcaaga gataagtctt tcatggctgc tgttgcttaa accacttaaa     3690

cgaagagttc ccttgaaact ttgggaaaac atgttaatga caatattcca gatctttcag     3750

aaatataaca catttttttg catgcatgca aatgagctct gaaatcttcc catgcattct     3810

ggtcaagggc tgtcattgca cataagcttc cattttaatt ttaaagtgca aaagggccag     3870

cgtggctcta aaaggtaatg tgtggattgc ctctgaaaag tgtgtatata ttttgtgtga     3930

aattgcatac tttgtatttt gattattttt tttttcttct tgggatagtg ggatttccag     3990

aaccacactt gaaacctttt tttatcgttt ttgtattttc atgaaaatac catttagtaa     4050

gaataccaca tcaaataaga aataatgcta caattttaag aggggaggga agggaaagtt     4110

tttttttatt atttttttaa aattttgtat gttaaagaga atgagtcctt gatttcaaag     4170

ttttgttgta cttaaatggt aataagcact gtaaacttct gcaacaagca tgcagctttg     4230

caaacccatt aaggggaaga atgaaagctg ttccttggtc ctagtaagaa gacaaactgc     4290

ttcccttact ttgctgaggg tttgaataaa cctaggactt ccgagctatg tcagtactat     4350

tcaggtaaca ctagggcctt ggaaattcct gtactgtgtc tcatggattt ggcactagcc     4410

aaagcgaggc acccttactg gcttacctcc tcatggcagc ctactctcct tgagtgtatg     4470

agtagccagg gtaaggggta aaaggatagt aagcatagaa accactagaa agtgggctta     4530

atggagttct tgtggcctca gctcaatgca gttagctgaa gaattgaaaa gtttttgttt     4590

ggagacgttt ataaacagaa atggaaagca gagttttcat taaatccttt tacctttttt     4650

ttttcttggt aatcccctaa aataacagta tgtgggatat tgaatgttaa agggatattt     4710

ttttctatta tttttataat tgtacaaaat taagcaaatg ttaaaagttt tatatgcttt     4770

attaatgttt tcaaaaggta ttatacatgt gatacatttt ttaagcttca gttgcttgtc     4830

ttctggtact ttctgttatg ggcttttggg gagccagaag ccaatctaca atctcttttt     4890

gtttgccagg acatgcaata aaatttaaaa aataaataaa aactaattaa gaaa           4944


<210>  61
<211>  680
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Asn Phe Glu Thr Ser Arg Cys Ala Thr Leu Gln Tyr Cys Pro Asp 
1               5                   10                  15      


Pro Tyr Ile Gln Arg Phe Val Glu Thr Pro Ala His Phe Ser Trp Lys 
            20                  25                  30          


Glu Ser Tyr Tyr Arg Ser Thr Met Ser Gln Ser Thr Gln Thr Asn Glu 
        35                  40                  45              


Phe Leu Ser Pro Glu Val Phe Gln His Ile Trp Asp Phe Leu Glu Gln 
    50                  55                  60                  


Pro Ile Cys Ser Val Gln Pro Ile Asp Leu Asn Phe Val Asp Glu Pro 
65                  70                  75                  80  


Ser Glu Asp Gly Ala Thr Asn Lys Ile Glu Ile Ser Met Asp Cys Ile 
                85                  90                  95      


Arg Met Gln Asp Ser Asp Leu Ser Asp Pro Met Trp Pro Gln Tyr Thr 
            100                 105                 110         


Asn Leu Gly Leu Leu Asn Ser Met Asp Gln Gln Ile Gln Asn Gly Ser 
        115                 120                 125             


Ser Ser Thr Ser Pro Tyr Asn Thr Asp His Ala Gln Asn Ser Val Thr 
    130                 135                 140                 


Ala Pro Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Ala Leu Ser 
145                 150                 155                 160 


Pro Ser Pro Ala Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro His Ser 
                165                 170                 175     


Phe Asp Val Ser Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala Thr Trp 
            180                 185                 190         


Thr Tyr Ser Thr Glu Leu Lys Lys Leu Tyr Cys Gln Ile Ala Lys Thr 
        195                 200                 205             


Cys Pro Ile Gln Ile Lys Val Met Thr Pro Pro Pro Gln Gly Ala Val 
    210                 215                 220                 


Ile Arg Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr Glu Val 
225                 230                 235                 240 


Val Lys Arg Cys Pro Asn His Glu Leu Ser Arg Glu Phe Asn Glu Gly 
                245                 250                 255     


Gln Ile Ala Pro Pro Ser His Leu Ile Arg Val Glu Gly Asn Ser His 
            260                 265                 270         


Ala Gln Tyr Val Glu Asp Pro Ile Thr Gly Arg Gln Ser Val Leu Val 
        275                 280                 285             


Pro Tyr Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Val Leu Tyr 
    290                 295                 300                 


Asn Phe Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg Arg Pro 
305                 310                 315                 320 


Ile Leu Ile Ile Val Thr Leu Glu Thr Arg Asp Gly Gln Val Leu Gly 
                325                 330                 335     


Arg Arg Cys Phe Glu Ala Arg Ile Cys Ala Cys Pro Gly Arg Asp Arg 
            340                 345                 350         


Lys Ala Asp Glu Asp Ser Ile Arg Lys Gln Gln Val Ser Asp Ser Thr 
        355                 360                 365             


Lys Asn Gly Asp Gly Thr Lys Arg Pro Phe Arg Gln Asn Thr His Gly 
    370                 375                 380                 


Ile Gln Met Thr Ser Ile Lys Lys Arg Arg Ser Pro Asp Asp Glu Leu 
385                 390                 395                 400 


Leu Tyr Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys 
                405                 410                 415     


Ile Lys Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile 
            420                 425                 430         


Glu Thr Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln 
        435                 440                 445             


Lys Gln Thr Ser Ile Gln Ser Pro Ser Ser Tyr Gly Asn Ser Ser Pro 
    450                 455                 460                 


Pro Leu Asn Lys Met Asn Ser Met Asn Lys Leu Pro Ser Val Ser Gln 
465                 470                 475                 480 


Leu Ile Asn Pro Gln Gln Arg Asn Ala Leu Thr Pro Thr Thr Ile Pro 
                485                 490                 495     


Asp Gly Met Gly Ala Asn Ile Pro Met Met Gly Thr His Met Pro Met 
            500                 505                 510         


Ala Gly Asp Met Asn Gly Leu Ser Pro Thr Gln Ala Leu Pro Pro Pro 
        515                 520                 525             


Leu Ser Met Pro Ser Thr Ser His Cys Thr Pro Pro Pro Pro Tyr Pro 
    530                 535                 540                 


Thr Asp Cys Ser Ile Val Ser Phe Leu Ala Arg Leu Gly Cys Ser Ser 
545                 550                 555                 560 


Cys Leu Asp Tyr Phe Thr Thr Gln Gly Leu Thr Thr Ile Tyr Gln Ile 
                565                 570                 575     


Glu His Tyr Ser Met Asp Asp Leu Ala Ser Leu Lys Ile Pro Glu Gln 
            580                 585                 590         


Phe Arg His Ala Ile Trp Lys Gly Ile Leu Asp His Arg Gln Leu His 
        595                 600                 605             


Glu Phe Ser Ser Pro Ser His Leu Leu Arg Thr Pro Ser Ser Ala Ser 
    610                 615                 620                 


Thr Val Ser Val Gly Ser Ser Glu Thr Arg Gly Glu Arg Val Ile Asp 
625                 630                 635                 640 


Ala Val Arg Phe Thr Leu Arg Gln Thr Ile Ser Phe Pro Pro Arg Asp 
                645                 650                 655     


Glu Trp Asn Asp Phe Asn Phe Asp Met Asp Ala Arg Arg Asn Lys Gln 
            660                 665                 670         


Gln Arg Ile Lys Glu Glu Gly Glu 
        675                 680 


<210>  62
<211>  7501
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (297)..(4265)

<400>  62
gggcagaccc tggagatcgg gctcgcggcg ccttccatcg tggctccgcg ctggggcttg       60

cggagcacgc ttcccgcccc tcggagcccg cgggcccggc cgccccgccc ccgggcgccc      120

tgagcgagca ggcggggagg gcggggaggg tccgcgcgtt ggtggtgctc gcctcgcagc      180

tgcgcccgcc ggcttcagca ccttccgctg tccgccgctg cagccgcctc ctcctccagg      240

tgctgactat tctgatgccg agtttccaat tgccttgatt aaagtagaaa cattct atg      299
                                                              Met         
                                                              1           

gct tgg atg act tac att tca aat tgg ttt gag caa gat gat tgg tat        347
Ala Trp Met Thr Tyr Ile Ser Asn Trp Phe Glu Gln Asp Asp Trp Tyr           
            5                   10                  15                    

gaa gga cta caa aga gca aac atg tcc cag gta agg caa gtg gga ttg        395
Glu Gly Leu Gln Arg Ala Asn Met Ser Gln Val Arg Gln Val Gly Leu           
        20                  25                  30                        

ctg gct gct gga tgt cag cca tgg aac aag gat gta tgt gct gcc agt        443
Leu Ala Ala Gly Cys Gln Pro Trp Asn Lys Asp Val Cys Ala Ala Ser           
    35                  40                  45                            

gga gac agg ttt gca tat tgt gcg acc ctg gct atc tat att tat cag        491
Gly Asp Arg Phe Ala Tyr Cys Ala Thr Leu Ala Ile Tyr Ile Tyr Gln           
50                  55                  60                  65            

ttg gat cac cgt tat aat gaa ttc aaa ctt cac gca att atg tct gaa        539
Leu Asp His Arg Tyr Asn Glu Phe Lys Leu His Ala Ile Met Ser Glu           
                70                  75                  80                

cat aaa aaa aca atc aca gca att tct tgg tgt cca cat aat cct gat        587
His Lys Lys Thr Ile Thr Ala Ile Ser Trp Cys Pro His Asn Pro Asp           
            85                  90                  95                    

ctg ttt gca agt ggc agt act gat aat tta gtg atc att tgg aat gtt        635
Leu Phe Ala Ser Gly Ser Thr Asp Asn Leu Val Ile Ile Trp Asn Val           
        100                 105                 110                       

gca gaa caa aaa gtc att gct aaa ctc gac agt aca aaa ggg atc cct        683
Ala Glu Gln Lys Val Ile Ala Lys Leu Asp Ser Thr Lys Gly Ile Pro           
    115                 120                 125                           

gct tct ctt agt tgg tgc tgg aat gca gag gat gtg gtg gca ttt gtt        731
Ala Ser Leu Ser Trp Cys Trp Asn Ala Glu Asp Val Val Ala Phe Val           
130                 135                 140                 145           

tcc cac aga ggc cca ctg ttc att tgg acc atc tca gga cca gat agt        779
Ser His Arg Gly Pro Leu Phe Ile Trp Thr Ile Ser Gly Pro Asp Ser           
                150                 155                 160               

gga gtg att gta cac aaa gat gct cat agc ttc ttg tct gat atc tgt        827
Gly Val Ile Val His Lys Asp Ala His Ser Phe Leu Ser Asp Ile Cys           
            165                 170                 175                   

atg ttc aga tgg cat aca cac caa aag ggg aaa gtt gtg ttt ggt cat        875
Met Phe Arg Trp His Thr His Gln Lys Gly Lys Val Val Phe Gly His           
        180                 185                 190                       

att gat gga agt cta tca att ttt cat cca ggt aat aaa aat cag aaa        923
Ile Asp Gly Ser Leu Ser Ile Phe His Pro Gly Asn Lys Asn Gln Lys           
    195                 200                 205                           

cat gtt ttg aga cca gaa tct ctt gaa ggg aca gat gaa gag gat cca        971
His Val Leu Arg Pro Glu Ser Leu Glu Gly Thr Asp Glu Glu Asp Pro           
210                 215                 220                 225           

gtt acg gcc ttg gaa tgg gac cca cta tct act gat tat ctt cta gtg       1019
Val Thr Ala Leu Glu Trp Asp Pro Leu Ser Thr Asp Tyr Leu Leu Val           
                230                 235                 240               

gtt aat ttg cat tat gga att cgc ctg gta gat tct gaa tca ctt tct       1067
Val Asn Leu His Tyr Gly Ile Arg Leu Val Asp Ser Glu Ser Leu Ser           
            245                 250                 255                   

tgc ata aca aca ttt aat ctt ccc agt gca gca gct tct gta cag tgc       1115
Cys Ile Thr Thr Phe Asn Leu Pro Ser Ala Ala Ala Ser Val Gln Cys           
        260                 265                 270                       

tta gcc tgg gtt ccc agt gct cct ggg atg ttt ata act gga gat tct       1163
Leu Ala Trp Val Pro Ser Ala Pro Gly Met Phe Ile Thr Gly Asp Ser           
    275                 280                 285                           

caa gtg ggt gtt tta cgc att tgg aat gtt tca aga aca aca cct att       1211
Gln Val Gly Val Leu Arg Ile Trp Asn Val Ser Arg Thr Thr Pro Ile           
290                 295                 300                 305           

gat aat ctt aaa tta aag aaa aca gga ttt cac tgc tta cat gta ctt       1259
Asp Asn Leu Lys Leu Lys Lys Thr Gly Phe His Cys Leu His Val Leu           
                310                 315                 320               

aat tct cct cca aga aaa aag ttt tca gtc caa tct cca acc aaa aat       1307
Asn Ser Pro Pro Arg Lys Lys Phe Ser Val Gln Ser Pro Thr Lys Asn           
            325                 330                 335                   

cat tat aca tcc tca aca agc gaa gca gtt cca ccc cca act tta aca       1355
His Tyr Thr Ser Ser Thr Ser Glu Ala Val Pro Pro Pro Thr Leu Thr           
        340                 345                 350                       

cag aat caa gca ttt tct ctt cct cct ggt cat gca gtg tgt tgt ttc       1403
Gln Asn Gln Ala Phe Ser Leu Pro Pro Gly His Ala Val Cys Cys Phe           
    355                 360                 365                           

ttg gat ggt gga gtt gga ctt tat gat atg gga gct aag aag tgg gat       1451
Leu Asp Gly Gly Val Gly Leu Tyr Asp Met Gly Ala Lys Lys Trp Asp           
370                 375                 380                 385           

ttt ctt aga gac ttg gga cat gtg gaa act atc ttt gac tgc aaa ttc       1499
Phe Leu Arg Asp Leu Gly His Val Glu Thr Ile Phe Asp Cys Lys Phe           
                390                 395                 400               

aaa cct gac gat cct aat ctt tta gca aca gct tca ttt gat ggc act       1547
Lys Pro Asp Asp Pro Asn Leu Leu Ala Thr Ala Ser Phe Asp Gly Thr           
            405                 410                 415                   

ata aaa gtc tgg gat ata aac aca tta aca gca gtg tac aca tcc ccg       1595
Ile Lys Val Trp Asp Ile Asn Thr Leu Thr Ala Val Tyr Thr Ser Pro           
        420                 425                 430                       

ggt aat gaa ggt gtt att tat tcc ctt tct tgg gct cca ggt ggt tta       1643
Gly Asn Glu Gly Val Ile Tyr Ser Leu Ser Trp Ala Pro Gly Gly Leu           
    435                 440                 445                           

aat tgt att gct ggg gga act tcc cga aat ggt gct ttt att tgg aat       1691
Asn Cys Ile Ala Gly Gly Thr Ser Arg Asn Gly Ala Phe Ile Trp Asn           
450                 455                 460                 465           

gtt caa aag ggc aaa att ata caa cga ttt aat gag cat gga aca aat       1739
Val Gln Lys Gly Lys Ile Ile Gln Arg Phe Asn Glu His Gly Thr Asn           
                470                 475                 480               

gga ata ttc tgc att gcc tgg agt cat aaa gat tct aaa aga ata gca       1787
Gly Ile Phe Cys Ile Ala Trp Ser His Lys Asp Ser Lys Arg Ile Ala           
            485                 490                 495                   

acc tgc agc agt gat ggt ttc tgt att att cga aca att gat ggt aaa       1835
Thr Cys Ser Ser Asp Gly Phe Cys Ile Ile Arg Thr Ile Asp Gly Lys           
        500                 505                 510                       

gtg cta cac aaa tat aaa cat cca gct gca gtg ttt ggt tgt gat tgg       1883
Val Leu His Lys Tyr Lys His Pro Ala Ala Val Phe Gly Cys Asp Trp           
    515                 520                 525                           

agc caa aac aat aaa gac atg ata gcc act ggc tgt gaa gac aca aat       1931
Ser Gln Asn Asn Lys Asp Met Ile Ala Thr Gly Cys Glu Asp Thr Asn           
530                 535                 540                 545           

gtt cgt gtt tat tat gta gcc acc agc tca gat caa cca ttg aaa gta       1979
Val Arg Val Tyr Tyr Val Ala Thr Ser Ser Asp Gln Pro Leu Lys Val           
                550                 555                 560               

ttt agt ggg cat aca gca aaa gtg ttt cat gtt aaa tgg tct cct ctg       2027
Phe Ser Gly His Thr Ala Lys Val Phe His Val Lys Trp Ser Pro Leu           
            565                 570                 575                   

aga gag gga att ctt tgc agt ggt tct gat gat ggt acc gtt cga atc       2075
Arg Glu Gly Ile Leu Cys Ser Gly Ser Asp Asp Gly Thr Val Arg Ile           
        580                 585                 590                       

tgg gat tat act cag gat gct tgc atc aat att ctt aat gga cac act       2123
Trp Asp Tyr Thr Gln Asp Ala Cys Ile Asn Ile Leu Asn Gly His Thr           
    595                 600                 605                           

gca cct gtg aga gga tta atg tgg aat act gag att cca tat ctg ctc       2171
Ala Pro Val Arg Gly Leu Met Trp Asn Thr Glu Ile Pro Tyr Leu Leu           
610                 615                 620                 625           

ata tct ggc agc tgg gac tat act ata aaa gta tgg gac act cga gaa       2219
Ile Ser Gly Ser Trp Asp Tyr Thr Ile Lys Val Trp Asp Thr Arg Glu           
                630                 635                 640               

gga act tgt gtg gat act gtg tat gat cac ggt gca gat gta tat ggt       2267
Gly Thr Cys Val Asp Thr Val Tyr Asp His Gly Ala Asp Val Tyr Gly           
            645                 650                 655                   

tta acc tgc cat ccc agt cgc ccc ttc act atg gcc tct tgc tcc cgt       2315
Leu Thr Cys His Pro Ser Arg Pro Phe Thr Met Ala Ser Cys Ser Arg           
        660                 665                 670                       

gac tct aca gtg aga ctc tgg tca tta aca gcc tta gtc act cct gta       2363
Asp Ser Thr Val Arg Leu Trp Ser Leu Thr Ala Leu Val Thr Pro Val           
    675                 680                 685                           

caa ata aat att ctg gca gac aga tct tgg gaa gaa att att ggg aac       2411
Gln Ile Asn Ile Leu Ala Asp Arg Ser Trp Glu Glu Ile Ile Gly Asn           
690                 695                 700                 705           

act gat tat gct ata gaa cca ggc act cct cct cta ctg tgt ggt aaa       2459
Thr Asp Tyr Ala Ile Glu Pro Gly Thr Pro Pro Leu Leu Cys Gly Lys           
                710                 715                 720               

gtg tca aga gat att aga cag gaa ata gaa aaa cta act gct aat tct       2507
Val Ser Arg Asp Ile Arg Gln Glu Ile Glu Lys Leu Thr Ala Asn Ser           
            725                 730                 735                   

caa gtg aaa aaa cta aga tgg ttc tca gaa tgt tta tct cct cca ggt       2555
Gln Val Lys Lys Leu Arg Trp Phe Ser Glu Cys Leu Ser Pro Pro Gly           
        740                 745                 750                       

ggc agt gac aat tta tgg aac ttg gtt gct gtg ata aaa gga cag gat       2603
Gly Ser Asp Asn Leu Trp Asn Leu Val Ala Val Ile Lys Gly Gln Asp           
    755                 760                 765                           

gat agc tta ctt cct cag aac tac tgc aaa gga ata atg cac ttg aaa       2651
Asp Ser Leu Leu Pro Gln Asn Tyr Cys Lys Gly Ile Met His Leu Lys           
770                 775                 780                 785           

cat ctg att aaa ttt aga aca tct gaa gct caa gaa cta aca aca gtc       2699
His Leu Ile Lys Phe Arg Thr Ser Glu Ala Gln Glu Leu Thr Thr Val           
                790                 795                 800               

aag atg tct aaa ttt ggt ggt ggt att ggt gta cct gct aaa gag gaa       2747
Lys Met Ser Lys Phe Gly Gly Gly Ile Gly Val Pro Ala Lys Glu Glu           
            805                 810                 815                   

aga ctg aag gaa gct gct gaa atc cac ttg aga tta gga caa att cag       2795
Arg Leu Lys Glu Ala Ala Glu Ile His Leu Arg Leu Gly Gln Ile Gln           
        820                 825                 830                       

aga tac tgt gaa ctt atg gtt gaa ctt gga gag tgg gac aaa gcc ctg       2843
Arg Tyr Cys Glu Leu Met Val Glu Leu Gly Glu Trp Asp Lys Ala Leu           
    835                 840                 845                           

tca att gca cca gga gtc tct gtg aaa tac tgg aag aag tta atg cag       2891
Ser Ile Ala Pro Gly Val Ser Val Lys Tyr Trp Lys Lys Leu Met Gln           
850                 855                 860                 865           

agg aga gct gac caa tta atc cag gaa gat aag gat gat gtc att cca       2939
Arg Arg Ala Asp Gln Leu Ile Gln Glu Asp Lys Asp Asp Val Ile Pro           
                870                 875                 880               

tac tgc ata gcc att ggt gat gtg aaa aag cta gtc cat ttt ttc atg       2987
Tyr Cys Ile Ala Ile Gly Asp Val Lys Lys Leu Val His Phe Phe Met           
            885                 890                 895                   

tca aga ggt cag ctt aaa gaa gct ctg ctt gtt gca cag gct gct tgt       3035
Ser Arg Gly Gln Leu Lys Glu Ala Leu Leu Val Ala Gln Ala Ala Cys           
        900                 905                 910                       

gaa gga aat atg cag ccc tta cat gtt tcc gtg cct aaa gga gct tca       3083
Glu Gly Asn Met Gln Pro Leu His Val Ser Val Pro Lys Gly Ala Ser           
    915                 920                 925                           

tat tct gat gat atc tac aag gaa gac ttt aat gaa ctc ctg cac aaa       3131
Tyr Ser Asp Asp Ile Tyr Lys Glu Asp Phe Asn Glu Leu Leu His Lys           
930                 935                 940                 945           

gtc agt aaa gaa ctg gca gaa tgg tat ttt caa gat ggt cga gca gta       3179
Val Ser Lys Glu Leu Ala Glu Trp Tyr Phe Gln Asp Gly Arg Ala Val           
                950                 955                 960               

cta gcc gca tgt tgc cat ctt gcc ata gat aat att gag ctt gct atg       3227
Leu Ala Ala Cys Cys His Leu Ala Ile Asp Asn Ile Glu Leu Ala Met           
            965                 970                 975                   

gca tac ctg att cgc gga aat gaa ctg gag ttg gca gtc tgt gtg ggc       3275
Ala Tyr Leu Ile Arg Gly Asn Glu Leu Glu Leu Ala Val Cys Val Gly           
        980                 985                 990                       

aca gta cta gga gag tct gca  gca cca gca acc cac  tat gcc tta gaa     3323
Thr Val Leu Gly Glu Ser Ala  Ala Pro Ala Thr His  Tyr Ala Leu Glu         
    995                 1000                 1005                         

tta  ctg gcg aga aag tgc  atg atg att tca gta  tgc ttt cca tgt        3368
Leu  Leu Ala Arg Lys Cys  Met Met Ile Ser Val  Cys Phe Pro Cys            
1010                 1015                 1020                            

gtt  gga tac agt gtc ccc  ttt tgt tac gtt aac  agg aat ttg gca        3413
Val  Gly Tyr Ser Val Pro  Phe Cys Tyr Val Asn  Arg Asn Leu Ala            
1025                 1030                 1035                            

gct  gat ctt ctt ctg atg  att cct gat aat gaa  cta cat tta ata        3458
Ala  Asp Leu Leu Leu Met  Ile Pro Asp Asn Glu  Leu His Leu Ile            
1040                 1045                 1050                            

aaa  ctc tgt gct ttc tac  cca gga tgt act gaa  gag ata aat gac        3503
Lys  Leu Cys Ala Phe Tyr  Pro Gly Cys Thr Glu  Glu Ile Asn Asp            
1055                 1060                 1065                            

ctt  cat gat aag tgt aag  cta ccc aca gtg gaa  gaa tgt atg cag        3548
Leu  His Asp Lys Cys Lys  Leu Pro Thr Val Glu  Glu Cys Met Gln            
1070                 1075                 1080                            

tta  gct gag aca gcc cgt  gca gat gac aat ata  ttt gaa act gta        3593
Leu  Ala Glu Thr Ala Arg  Ala Asp Asp Asn Ile  Phe Glu Thr Val            
1085                 1090                 1095                            

aaa  tat tac ttg tta agt  caa gaa cct gaa aaa  gcc ctt cct att        3638
Lys  Tyr Tyr Leu Leu Ser  Gln Glu Pro Glu Lys  Ala Leu Pro Ile            
1100                 1105                 1110                            

ggt  att agc ttt gtt aaa  gaa tac atc agt agc  tca gac tgg act        3683
Gly  Ile Ser Phe Val Lys  Glu Tyr Ile Ser Ser  Ser Asp Trp Thr            
1115                 1120                 1125                            

ttg  gat acc ata tac cct  gtt ctt gac cta ctg  agc tat att cgt        3728
Leu  Asp Thr Ile Tyr Pro  Val Leu Asp Leu Leu  Ser Tyr Ile Arg            
1130                 1135                 1140                            

act  gaa aaa tta ctc ttg  cat acg tgt act gaa  gct cga aat gag        3773
Thr  Glu Lys Leu Leu Leu  His Thr Cys Thr Glu  Ala Arg Asn Glu            
1145                 1150                 1155                            

ttg  ctg ata tta tgt ggt  tac att ggt gca tta  ctg gct atc aga        3818
Leu  Leu Ile Leu Cys Gly  Tyr Ile Gly Ala Leu  Leu Ala Ile Arg            
1160                 1165                 1170                            

aga  cag tac caa agc att  gtt cca gca ctt tat  gag tac aca agt        3863
Arg  Gln Tyr Gln Ser Ile  Val Pro Ala Leu Tyr  Glu Tyr Thr Ser            
1175                 1180                 1185                            

cag  cta tta aaa cgt cgg  gag gtg tca gta cct  tta aaa att gaa        3908
Gln  Leu Leu Lys Arg Arg  Glu Val Ser Val Pro  Leu Lys Ile Glu            
1190                 1195                 1200                            

tat  ctt tct gag gaa ttg  gat gca tgg aga gct  tgc aca cag tcc        3953
Tyr  Leu Ser Glu Glu Leu  Asp Ala Trp Arg Ala  Cys Thr Gln Ser            
1205                 1210                 1215                            

acc  aac aga tca tta gaa  gac tct ccg tat aca  ccc cct tct gat        3998
Thr  Asn Arg Ser Leu Glu  Asp Ser Pro Tyr Thr  Pro Pro Ser Asp            
1220                 1225                 1230                            

tca  caa aga atg att tat  gca act tta tta aag  aga cta aaa gaa        4043
Ser  Gln Arg Met Ile Tyr  Ala Thr Leu Leu Lys  Arg Leu Lys Glu            
1235                 1240                 1245                            

gag  tca ctg aaa gga att  att gga cca gat tat  gtg act gga tca        4088
Glu  Ser Leu Lys Gly Ile  Ile Gly Pro Asp Tyr  Val Thr Gly Ser            
1250                 1255                 1260                            

aat  ctt cca agt cat tct  gat att cac att tct  tgt ctt acg gga        4133
Asn  Leu Pro Ser His Ser  Asp Ile His Ile Ser  Cys Leu Thr Gly            
1265                 1270                 1275                            

tta  aaa atc cag ggc cct  gtg ttt ttc ctt gaa  gac ggg aaa tct        4178
Leu  Lys Ile Gln Gly Pro  Val Phe Phe Leu Glu  Asp Gly Lys Ser            
1280                 1285                 1290                            

gct  atc tcc ttg aat gat  gct ttg atg tgg gca  aag gtg aat cca        4223
Ala  Ile Ser Leu Asn Asp  Ala Leu Met Trp Ala  Lys Val Asn Pro            
1295                 1300                 1305                            

ttc  tca cct tta ggg act  gga ata cga ctc aat  cca ttc tga            4265
Phe  Ser Pro Leu Gly Thr  Gly Ile Arg Leu Asn  Pro Phe                    
1310                 1315                 1320                            

tagaagattt ttgtccatgc ttgatttttt tttttaaaga aaaactttca tgggttagca     4325

ttaccttaat ctttgttgct caagtgccag aggttgggag aaggattgca ggttgggaga     4385

ggtgggaaat agcagtgaat tttagtcatt aacttcaaaa tatatatata tatataattt     4445

aaaggaaaaa taggtgcctc ctttataaac agtaatagct acgtttggga aggaggaaac     4505

atttaaatta taaaggactg aataatctaa aaagcatata aaagtttcac acagcataaa     4565

agataccaaa atatcatatg gttgaaatat tgaaacatat taaattgtgc aacacctaga     4625

atagtgctag acatacagta agtacttaat ggatatttga atgattgaat atcttgaaat     4685

gttgaaatgt aaggtgtgca cagtgatctt caacttaaca aacacttacg ttctccttta     4745

taaaatgcat agtaaaccac taacgttagc tgttttaata aaagttttca gttataagtt     4805

tagtaaatat taataaatgg atacacattc aaaatacttt taaaaaaaag aaaatgttac     4865

cagttttttt atctgaagtt taactgtccc attgtaaagg tgtaagttat ataggcttga     4925

aaaaaattgg cgggtaaaaa tcacaaaatg cagtcgaata tatatatgaa aacttgcatt     4985

aggtgataaa gtgactattt taagagattc agcatgcatg gatattagtt ttgattaatg     5045

tgtacaataa tttacacagt atactctagt caatttatgt taactttatt taaaacacaa     5105

tttatttggc cgggcacggt ggctcacacc tgtaatctca gcactttggc aggccaaggc     5165

aggtggatca cctgaggtca ggagttcatg accagcctgg ccagcatggt aaaaccctgt     5225

ctccactaaa aatacaaaaa ttagccaggc atggtggcgg gcacctgtaa tcccagttac     5285

ttgggaagct gaggcaggag aatcccttga acctgggagg cagaggttcc agtgagccaa     5345

gatcgcacca ctgcactcca gcctgggcaa caaagagcga aactctgtct caaaaaacaa     5405

accaacaaaa accacaattg atttgatgaa aattagtttt aagtaaatgt ttgtaaatag     5465

atattggttg aatttttgga tatattatgt tgatttaact tttaaaatgt tgtttaaaag     5525

tgtgaagcta tgaaaagcct gataatgtga ctacagatat ttcagttgga ctagaattct     5585

gactttgaaa cttattaaat taatgcatac tggaagtact ttgatactca agttgtttca     5645

caagatttat aatatagatg gttttgtttg actaaagaat aatctcatat aactagaata     5705

cttgtggctt ttattatctt taaacttgtt gcatttaaaa tatttttaaa accttcttaa     5765

caaaacttct taaaactgga aaaaatatat attatgtatc tatgtatcat atttatcaca     5825

tgaccacttt tgattcctta aaaagacatt acaggcttaa attccatttt attaaaaaaa     5885

aaaaattgcc tgtaatccca gcacttcagg aggccgagat gggcagatct tgaggtcggt     5945

agatggagac catcctggcc aacatggtga aaccctgtct ctactaaaaa tacaaaaatt     6005

agctgggtgt ggtggtgtgt acctgtagtc ccagctaccc aggaagctaa ggcaggagaa     6065

tcgcttgaat ccaggaggcg gaggttgcag tgagctgaga tcgcactact gcactccagc     6125

ctgggcgaca gagcaagacc accatctcca aaaattatat atataaaaat aattaatatt     6185

atagaagaga atatacacaa ctcagagatg caatggataa tataaaaaga gtacctgaga     6245

tgtatttttt taaactctta gagatatctg taactcaaat ttttcttagg tgaggaggat     6305

tattaactgg cacatatgta ctaaaaaccc ctcacttaaa aatggcagtc tcaatcctac     6365

tgtcattctt tttattttaa aataaataaa taagcctatc tttttgtgct tacatactta     6425

aaaggatatc attaagtata taaacaatca ttacttctgt atttttaatg aatgcaggaa     6485

aataatattt ttatgtataa aagatgaaga aaaaattttg caagtcttta agcacataaa     6545

tacaacagaa tagccaccca atttctgtct gaaatctaaa ttggatggat ttgaccatca     6605

ttctattatc tttgatttct acaatgtcta tatcttatta cctataacta ttaatttttc     6665

atagaattat aaatgtcatt tgactatgtc aatctgtata tattgtacct taatatgaaa     6725

aacaaatttt ttaattcata aaagtatttt tattagattt catatgcatg aaacccaagc     6785

aaattatatg aatttatttt actatttgaa aatgttcata ttaccaataa tgtggacaaa     6845

ttactttgca ggtttaaata tgcctctgta aaggaagagt ctcattagac aatgattttt     6905

aaagcattgg aaaaatattt tgcctgtaaa agttagtaac taggtggttc acaaaattac     6965

aacatcaaaa tagttacatc ttgtgaaaat atatgatttt tatgtcaatc aagacaaatg     7025

aaatatatat gtatgtgtat atatatacat gtatgtatga aatatatata tgtgcgtgtg     7085

tgtgtgtata tatatatata tatatatata tttctatgaa attgtccaga tgtgttcagg     7145

aacatgattg cattagagca atgactgtat tttgttgtcc ttataacatt tatattattt     7205

cagttttaag tcaaaaggta ttctgaatat aataaaagcc tcacaaatta tttgtaaaat     7265

ttagtagttc atatttagta tatcagtaat atagaagaca tctttatagt caactcttaa     7325

ttaatgctta ttgtaccaaa tctttgagat atttgtacat aaatgaaata tgtactttca     7385

tgctaaaatt atatatcatg actgtgctat aatttggcat gtcattatct agatttatat     7445

gtatgtacgt atttcaggtc cttgaaattt taataaatat tacagttaaa tcctga         7501


<210>  63
<211>  1322
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ala Trp Met Thr Tyr Ile Ser Asn Trp Phe Glu Gln Asp Asp Trp 
1               5                   10                  15      


Tyr Glu Gly Leu Gln Arg Ala Asn Met Ser Gln Val Arg Gln Val Gly 
            20                  25                  30          


Leu Leu Ala Ala Gly Cys Gln Pro Trp Asn Lys Asp Val Cys Ala Ala 
        35                  40                  45              


Ser Gly Asp Arg Phe Ala Tyr Cys Ala Thr Leu Ala Ile Tyr Ile Tyr 
    50                  55                  60                  


Gln Leu Asp His Arg Tyr Asn Glu Phe Lys Leu His Ala Ile Met Ser 
65                  70                  75                  80  


Glu His Lys Lys Thr Ile Thr Ala Ile Ser Trp Cys Pro His Asn Pro 
                85                  90                  95      


Asp Leu Phe Ala Ser Gly Ser Thr Asp Asn Leu Val Ile Ile Trp Asn 
            100                 105                 110         


Val Ala Glu Gln Lys Val Ile Ala Lys Leu Asp Ser Thr Lys Gly Ile 
        115                 120                 125             


Pro Ala Ser Leu Ser Trp Cys Trp Asn Ala Glu Asp Val Val Ala Phe 
    130                 135                 140                 


Val Ser His Arg Gly Pro Leu Phe Ile Trp Thr Ile Ser Gly Pro Asp 
145                 150                 155                 160 


Ser Gly Val Ile Val His Lys Asp Ala His Ser Phe Leu Ser Asp Ile 
                165                 170                 175     


Cys Met Phe Arg Trp His Thr His Gln Lys Gly Lys Val Val Phe Gly 
            180                 185                 190         


His Ile Asp Gly Ser Leu Ser Ile Phe His Pro Gly Asn Lys Asn Gln 
        195                 200                 205             


Lys His Val Leu Arg Pro Glu Ser Leu Glu Gly Thr Asp Glu Glu Asp 
    210                 215                 220                 


Pro Val Thr Ala Leu Glu Trp Asp Pro Leu Ser Thr Asp Tyr Leu Leu 
225                 230                 235                 240 


Val Val Asn Leu His Tyr Gly Ile Arg Leu Val Asp Ser Glu Ser Leu 
                245                 250                 255     


Ser Cys Ile Thr Thr Phe Asn Leu Pro Ser Ala Ala Ala Ser Val Gln 
            260                 265                 270         


Cys Leu Ala Trp Val Pro Ser Ala Pro Gly Met Phe Ile Thr Gly Asp 
        275                 280                 285             


Ser Gln Val Gly Val Leu Arg Ile Trp Asn Val Ser Arg Thr Thr Pro 
    290                 295                 300                 


Ile Asp Asn Leu Lys Leu Lys Lys Thr Gly Phe His Cys Leu His Val 
305                 310                 315                 320 


Leu Asn Ser Pro Pro Arg Lys Lys Phe Ser Val Gln Ser Pro Thr Lys 
                325                 330                 335     


Asn His Tyr Thr Ser Ser Thr Ser Glu Ala Val Pro Pro Pro Thr Leu 
            340                 345                 350         


Thr Gln Asn Gln Ala Phe Ser Leu Pro Pro Gly His Ala Val Cys Cys 
        355                 360                 365             


Phe Leu Asp Gly Gly Val Gly Leu Tyr Asp Met Gly Ala Lys Lys Trp 
    370                 375                 380                 


Asp Phe Leu Arg Asp Leu Gly His Val Glu Thr Ile Phe Asp Cys Lys 
385                 390                 395                 400 


Phe Lys Pro Asp Asp Pro Asn Leu Leu Ala Thr Ala Ser Phe Asp Gly 
                405                 410                 415     


Thr Ile Lys Val Trp Asp Ile Asn Thr Leu Thr Ala Val Tyr Thr Ser 
            420                 425                 430         


Pro Gly Asn Glu Gly Val Ile Tyr Ser Leu Ser Trp Ala Pro Gly Gly 
        435                 440                 445             


Leu Asn Cys Ile Ala Gly Gly Thr Ser Arg Asn Gly Ala Phe Ile Trp 
    450                 455                 460                 


Asn Val Gln Lys Gly Lys Ile Ile Gln Arg Phe Asn Glu His Gly Thr 
465                 470                 475                 480 


Asn Gly Ile Phe Cys Ile Ala Trp Ser His Lys Asp Ser Lys Arg Ile 
                485                 490                 495     


Ala Thr Cys Ser Ser Asp Gly Phe Cys Ile Ile Arg Thr Ile Asp Gly 
            500                 505                 510         


Lys Val Leu His Lys Tyr Lys His Pro Ala Ala Val Phe Gly Cys Asp 
        515                 520                 525             


Trp Ser Gln Asn Asn Lys Asp Met Ile Ala Thr Gly Cys Glu Asp Thr 
    530                 535                 540                 


Asn Val Arg Val Tyr Tyr Val Ala Thr Ser Ser Asp Gln Pro Leu Lys 
545                 550                 555                 560 


Val Phe Ser Gly His Thr Ala Lys Val Phe His Val Lys Trp Ser Pro 
                565                 570                 575     


Leu Arg Glu Gly Ile Leu Cys Ser Gly Ser Asp Asp Gly Thr Val Arg 
            580                 585                 590         


Ile Trp Asp Tyr Thr Gln Asp Ala Cys Ile Asn Ile Leu Asn Gly His 
        595                 600                 605             


Thr Ala Pro Val Arg Gly Leu Met Trp Asn Thr Glu Ile Pro Tyr Leu 
    610                 615                 620                 


Leu Ile Ser Gly Ser Trp Asp Tyr Thr Ile Lys Val Trp Asp Thr Arg 
625                 630                 635                 640 


Glu Gly Thr Cys Val Asp Thr Val Tyr Asp His Gly Ala Asp Val Tyr 
                645                 650                 655     


Gly Leu Thr Cys His Pro Ser Arg Pro Phe Thr Met Ala Ser Cys Ser 
            660                 665                 670         


Arg Asp Ser Thr Val Arg Leu Trp Ser Leu Thr Ala Leu Val Thr Pro 
        675                 680                 685             


Val Gln Ile Asn Ile Leu Ala Asp Arg Ser Trp Glu Glu Ile Ile Gly 
    690                 695                 700                 


Asn Thr Asp Tyr Ala Ile Glu Pro Gly Thr Pro Pro Leu Leu Cys Gly 
705                 710                 715                 720 


Lys Val Ser Arg Asp Ile Arg Gln Glu Ile Glu Lys Leu Thr Ala Asn 
                725                 730                 735     


Ser Gln Val Lys Lys Leu Arg Trp Phe Ser Glu Cys Leu Ser Pro Pro 
            740                 745                 750         


Gly Gly Ser Asp Asn Leu Trp Asn Leu Val Ala Val Ile Lys Gly Gln 
        755                 760                 765             


Asp Asp Ser Leu Leu Pro Gln Asn Tyr Cys Lys Gly Ile Met His Leu 
    770                 775                 780                 


Lys His Leu Ile Lys Phe Arg Thr Ser Glu Ala Gln Glu Leu Thr Thr 
785                 790                 795                 800 


Val Lys Met Ser Lys Phe Gly Gly Gly Ile Gly Val Pro Ala Lys Glu 
                805                 810                 815     


Glu Arg Leu Lys Glu Ala Ala Glu Ile His Leu Arg Leu Gly Gln Ile 
            820                 825                 830         


Gln Arg Tyr Cys Glu Leu Met Val Glu Leu Gly Glu Trp Asp Lys Ala 
        835                 840                 845             


Leu Ser Ile Ala Pro Gly Val Ser Val Lys Tyr Trp Lys Lys Leu Met 
    850                 855                 860                 


Gln Arg Arg Ala Asp Gln Leu Ile Gln Glu Asp Lys Asp Asp Val Ile 
865                 870                 875                 880 


Pro Tyr Cys Ile Ala Ile Gly Asp Val Lys Lys Leu Val His Phe Phe 
                885                 890                 895     


Met Ser Arg Gly Gln Leu Lys Glu Ala Leu Leu Val Ala Gln Ala Ala 
            900                 905                 910         


Cys Glu Gly Asn Met Gln Pro Leu His Val Ser Val Pro Lys Gly Ala 
        915                 920                 925             


Ser Tyr Ser Asp Asp Ile Tyr Lys Glu Asp Phe Asn Glu Leu Leu His 
    930                 935                 940                 


Lys Val Ser Lys Glu Leu Ala Glu Trp Tyr Phe Gln Asp Gly Arg Ala 
945                 950                 955                 960 


Val Leu Ala Ala Cys Cys His Leu Ala Ile Asp Asn Ile Glu Leu Ala 
                965                 970                 975     


Met Ala Tyr Leu Ile Arg Gly Asn Glu Leu Glu Leu Ala Val Cys Val 
            980                 985                 990         


Gly Thr Val Leu Gly Glu Ser Ala  Ala Pro Ala Thr His  Tyr Ala Leu 
        995                 1000                 1005             


Glu Leu  Leu Ala Arg Lys Cys  Met Met Ile Ser Val  Cys Phe Pro 
    1010                 1015                 1020             


Cys Val  Gly Tyr Ser Val Pro  Phe Cys Tyr Val Asn  Arg Asn Leu 
    1025                 1030                 1035             


Ala Ala  Asp Leu Leu Leu Met  Ile Pro Asp Asn Glu  Leu His Leu 
    1040                 1045                 1050             


Ile Lys  Leu Cys Ala Phe Tyr  Pro Gly Cys Thr Glu  Glu Ile Asn 
    1055                 1060                 1065             


Asp Leu  His Asp Lys Cys Lys  Leu Pro Thr Val Glu  Glu Cys Met 
    1070                 1075                 1080             


Gln Leu  Ala Glu Thr Ala Arg  Ala Asp Asp Asn Ile  Phe Glu Thr 
    1085                 1090                 1095             


Val Lys  Tyr Tyr Leu Leu Ser  Gln Glu Pro Glu Lys  Ala Leu Pro 
    1100                 1105                 1110             


Ile Gly  Ile Ser Phe Val Lys  Glu Tyr Ile Ser Ser  Ser Asp Trp 
    1115                 1120                 1125             


Thr Leu  Asp Thr Ile Tyr Pro  Val Leu Asp Leu Leu  Ser Tyr Ile 
    1130                 1135                 1140             


Arg Thr  Glu Lys Leu Leu Leu  His Thr Cys Thr Glu  Ala Arg Asn 
    1145                 1150                 1155             


Glu Leu  Leu Ile Leu Cys Gly  Tyr Ile Gly Ala Leu  Leu Ala Ile 
    1160                 1165                 1170             


Arg Arg  Gln Tyr Gln Ser Ile  Val Pro Ala Leu Tyr  Glu Tyr Thr 
    1175                 1180                 1185             


Ser Gln  Leu Leu Lys Arg Arg  Glu Val Ser Val Pro  Leu Lys Ile 
    1190                 1195                 1200             


Glu Tyr  Leu Ser Glu Glu Leu  Asp Ala Trp Arg Ala  Cys Thr Gln 
    1205                 1210                 1215             


Ser Thr  Asn Arg Ser Leu Glu  Asp Ser Pro Tyr Thr  Pro Pro Ser 
    1220                 1225                 1230             


Asp Ser  Gln Arg Met Ile Tyr  Ala Thr Leu Leu Lys  Arg Leu Lys 
    1235                 1240                 1245             


Glu Glu  Ser Leu Lys Gly Ile  Ile Gly Pro Asp Tyr  Val Thr Gly 
    1250                 1255                 1260             


Ser Asn  Leu Pro Ser His Ser  Asp Ile His Ile Ser  Cys Leu Thr 
    1265                 1270                 1275             


Gly Leu  Lys Ile Gln Gly Pro  Val Phe Phe Leu Glu  Asp Gly Lys 
    1280                 1285                 1290             


Ser Ala  Ile Ser Leu Asn Asp  Ala Leu Met Trp Ala  Lys Val Asn 
    1295                 1300                 1305             


Pro Phe  Ser Pro Leu Gly Thr  Gly Ile Arg Leu Asn  Pro Phe 
    1310                 1315                 1320         


<210>  64
<211>  5454
<212>  DNA
<213>  Homo sapiens

<400>  64
aggcatttcc ggcccagggg gcttggctcc ccgcggcacg ggatttagcg ttcgcgctcc       60

ttcccttccc gtggtcgagc cgagtcctga cctgagggct gcatcaagat cttgtcattc      120

cacatcgtgg tttcctttga ggatgtggct gtacccctct cccaggagga gtgggactgt      180

ctgatccctg ctcagagggg cctctacaag gatgtgatga tggggaccta tgggaaccta      240

ctctcattag taggtgaatg gttaagcaaa ctgtggtaca tccataccat gggatacgac      300

tcaacaatca aaaggaactg cccagacttc accacgatgc aatatatgca tgacttcaag      360

cttccaaacc tgatgtcatc tccaggctgg agcgggggga cgaaccatag acccctcaca      420

tcctgagaac tcaggggagc tggagctgga ggcacaagag agaaggctgt gattctagga      480

ttgaaaaaga ggaaatgatt ccaaagcagg acatttctga agaattggaa tcccagagag      540

caaaatcaga agatcatgta aggaatattt ttaaggaaac tgaagagatg agtaaaactg      600

agggaaagtt agagaattgc tggagaaaat atgcagtaga aggagttaag aactcattct      660

cccagaagag caatttcaga gaaattacca tgaggtatgt gaaaaccctc tctagagaga      720

atggccagaa gttcaatgct gttggagaaa actgcattac agactcaaat cctgccaaac      780

atcttagagg gtctagagag gagagtctcc atccaagtgt gtcaagtgta gaaaacttgc      840

aacaacatga ggacctcatt aacctccaga gtttccaatt aggagaaaga gcctatcaga      900

cagatgtgtt agtgaaagtg cccagacaga gctcagttct tagtgagaat cagaggatga      960

ataatccaga gagatggttt gagagtactg ggtgtggaaa aacttacaat cagaacagag     1020

cttttaacca gcaccagaga tttcatagtg gagagaagac ctatgagcac aatgaatgtg     1080

gaaaagcttt cagttggccc tctatcctca gtaaacatca gagaatccac actggtaaga     1140

aactctacac atgtgaggat tgtggcaaat ctttcagtgt tcactcatac tttattcagc     1200

attgtaaaat tcacactaga gaaaaaccct atgagtgtat taaatgtggg aaagctttta     1260

gtacacattc atcttatgtt caacatctaa aaattcatac aggagagaaa catcatgagt     1320

gtaatcagtg tgggaaagcc tttagtcata gctctaatct aattcatcat cagagaattc     1380

atagtggaga gaaaccttac aagtgcaaag aatgtgggaa agccttcaac agacaatcaa     1440

accttattca gcatcagaga attcattctg gagagaaacc ttatgactgt aaggagtgtg     1500

gcaaagcctt cagtacacaa ttatttctca ttcagcatca gagaattcat acaggagaaa     1560

agccctatga atgtaatgaa tgtgcaaaat cctttagcct gaaccgaact cttactgtcc     1620

atcagagaat tcacactgga gagaaacctt ataggtgtaa tgaatgtggg aaatccttta     1680

gtcaatgctc acaagttatt caacataaga gaattcacac tggagagaaa ccttatatct     1740

gcaatgagtg tggaaaatca tttggtgctc gtctatccct tatccagcat cagagaattc     1800

acactggaga gaaaccttat ggttgtagtg tgtgtgggaa aacctttagt caaaagggac     1860

atcttattca gcatcagtga attcacacag gagagaaacc ctatgaatgt agtgagtgtg     1920

gaaaagcttt cagccagagt tttaatctta ttcaccatca aagaacacac aatggtgaga     1980

agtcctatga atgtaatgaa tgtgataaag ccttcagttt gctttcttcc cttgttcaac     2040

atcagagaat acataatgga gacaaaccct atgagtgtca caaatgtggg aaggccttta     2100

gccaggggtc acaccttatt cagcatcaga ggagtcacat tggtgagaaa ccctatgagt     2160

gtaatgagtg tgggaaaacc tttgggcaga tatccaccct aattaagcat gagagaacac     2220

acaatggaga gaagccctat gagtgcagtg actgtgggaa ggccttcagc cagagtgcac     2280

accttatcca ccatcaaaga attcacactg gagagaatcc ctatgagtgc agtgaatgtg     2340

ggaaggcctt caatgtttgt tcctctctca ttcagcatca cagaattcat actggtgaga     2400

aaccttatga atgtagtgac tgtggcaagg cgttcagtca gcattcacaa tttatccaac     2460

atcagagaat tcacactgga gagaaaccct acatgtgcaa tgagtgtgag aaatccttca     2520

gtgcatgctt atcccttatc caacacaaga gaattcacac tggagagaaa ccctatgtat     2580

gtgccaaatg tggaaaatcc ttctgacaaa gctctcacct tattcaacat cagagaattc     2640

acagtgggga gcaacctcat acgtgtaatc gatgtgaaaa aaccttcagt tagagaataa     2700

ctcttagtag tcatgagaaa atccatacaa ttcacattag agagcaagtc tatgaatgta     2760

gtaagtgtgg ggaactctag cgcacagtca tctttcattc aacattgtac agttcacagt     2820

ggagagtaac tgattagtct ataaattctt cacagttata cattatatga gagtcatact     2880

cgtgagaaat gagtcacttt atggttttcc ttttggagat tcagctctta agggatttca     2940

ctctcccagt gagctgctaa ctaaaggcag gctgctgaag tatatagcag caatcccaca     3000

atagcacacc ttgcttcaga ttcagaggat gagccccctt cttgagccct gtagatatgt     3060

gaaacttaat tatttagatg catttcatgg caccagaccc taaggtacag ttaggtattt     3120

cactggagac cacttacttt gctttgcttt gctttttttt tttttttttt ttgtatgatt     3180

tatttcaact tcaaagaaag tagttgagat ccttgcactt ccaagtgtga tggaaccagg     3240

ctagggtttt ctttgtttgt ttgggcctct tcaaaacgtt tttattctgt tataaggaat     3300

atgatacctt aagcttcaat tcacagggaa gagaaacatg attataagca aaagtttgtc     3360

aaggaataag gtgagtcttt gtgtagatta aaatagttga gaccttgcta aaaagtcaga     3420

taacactgta atccacctcc aggtttccaa gagttaagac gctgccagca aggagcttgc     3480

agtcttgtag ctggcccaat atatccaact aattcaaaat gggaaattgt acattttact     3540

taaacaggat ttggtagatg ggtcttctag atatgttgtc atgaagaaaa atcaggaaaa     3600

tgtccaaggg tgggagcctg tggcttatgg cttcacttac ccatcacaga tagctatgtt     3660

acactgcaag aacagagttc atggcttttc ctgaggtggc tggaaacctt aatctcctga     3720

agttaagtca aaacttaaat gtcaattcac ccagctctct tgcctgcagg ctgatccagg     3780

gacttagagc ttgttaccca gttacaactt cttctagaga agaactttta agaaggaagc     3840

aaaaagaaat tcagtttccc ccaaggatct cttctttgag gttccatcaa gagatgacaa     3900

aaggaggctg ggcgcggtgt ctcacacctg taatcccagc actttgggag gctgaagtgg     3960

gcagatcacg aggtcaagag atcaagacca tcctggccaa catggtgaaa ccacatttct     4020

acaaaatgca aaaattagct gggcatggtg gtgcacgcct gtagtcccag ctacttggga     4080

ggctgaggca ggagaattgc ttgaacccag gaggcggagg tagcagtgag ccaagattgc     4140

accactgcat tccagcatgg ccacaaagca agactccaaa aaatatatat atatatgaca     4200

aaagggttag gaagcttttc ctctgaggcc cacgattaca caaccaaatc agaaaataat     4260

attttttttg ttttaaacct gtttacataa gatggaggtg tttacttaac taagaacctc     4320

ggtatttact caaatccggt tttgggtttt atggctaaaa catttctcca gattaacctt     4380

atcagtttgg aatatgtttt tattttccat taaatatttc atccaaatca tactgaattt     4440

tatttatcat ggcttttaat gttctctatt caagtcaaat ttctgtttcc taattacttg     4500

gcttggtgat ggcattaata ttggttggga gctagatggt ctctgctcta tttgatgatt     4560

ggcatagagc aatcatacac ttggtacttc ctagcatttt tttttgagac agtatcatgc     4620

tgtatcatgt tgcacagggt ggagtgcagt ggtgcagtca tagctcactg taaccttgaa     4680

ctcctgggct caagtgattc ccctgcctca acttcatgag tagcagggac tacagctgtg     4740

taccaccaca ccggcctctc ctggcttctt aaccacttac attaaaattg agaggagaaa     4800

ggcattttca gtttctttag ttaataaaaa gaagccattt ctggaggagt tttatgcctg     4860

taccagcaga ggttcagcct tccaggaatc tcatcatgat ccatactgct gacacaggcc     4920

tttgtcacct gaagcattct taaaataagg agactgacat taaacaggac aattgtgaac     4980

tccactttgt aagcatcata catatcttac aactcattct gaagactcct ttattcttgc     5040

tcttcccaga gagctactgt gtttagtcat gctcactgca ctcacaagag aaaaagagta     5100

agtggcatat ttgcaggtgt tgatggttac aagagcattt ttactttttc ctccatgttt     5160

gttctgcagc atttccattg atgcatgcta ttgtagactt cttaggttga ccttggcctt     5220

gacctccacc actagctcat gacccaaaac tgaagatgtg catcagaaag ggacagattt     5280

ggtctttctg ctgtaaaaga tattctgcct tagtgcctgc taatttgttg tgcatagtcc     5340

tgtgctgcca atcttcccca ccaattgtta aggttaatgt gtgttttata tgtgtattca     5400

caaacattaa aatgtaatca gtggattcca aaaaaaaaaa aaaaaaaaaa aaaa           5454


<210>  65
<211>  3061
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (303)..(1949)

<400>  65
gcgcacggcg aatccaccgg taccgtggtg gaagcgcgcc ctgggctgcc gggggcgcgg       60

ccgcggtggc acttggaccc gaggaggcgg caggtgagag gttccggagc tttccaggcg      120

ctctggggtc cagcaggagc tggtgcccgg gccggttggg tctcaggcct gagaagaacg      180

cagacgtctc gcctcatcgt cgctctgtgg ctttaccggc gtgagactac atttcccgcc      240

ggccctcgcg gcgtgcgctt tctggcgccc cctttctgct tccagcctca tagcccaggt      300

gc atg gac ccc tta gct cta ccg tcg cag gac tct gcc ctt ccc caa         347
   Met Asp Pro Leu Ala Leu Pro Ser Gln Asp Ser Ala Leu Pro Gln            
   1               5                   10                  15             

gag agg aac cag aag gag gac cta tca gcc ctt gaa att cta aaa gtc        395
Glu Arg Asn Gln Lys Glu Asp Leu Ser Ala Leu Glu Ile Leu Lys Val           
                20                  25                  30                

atg tcc ctt ggg tca gaa ttg ttc agg gat gtg gcc ata gtc ttc tcc        443
Met Ser Leu Gly Ser Glu Leu Phe Arg Asp Val Ala Ile Val Phe Ser           
            35                  40                  45                    

caa gaa gaa tgg cag tgg ttg gca cct gct cag agg gat ttg tac aga        491
Gln Glu Glu Trp Gln Trp Leu Ala Pro Ala Gln Arg Asp Leu Tyr Arg           
        50                  55                  60                        

gac gtg atg ttg gag acc tac agc aac ctg gtc tca ctg ggt ctt gcc        539
Asp Val Met Leu Glu Thr Tyr Ser Asn Leu Val Ser Leu Gly Leu Ala           
    65                  70                  75                            

gtt tcc aaa cct gat gtg atc tcc ttc cta gag caa ggc aaa gag ccc        587
Val Ser Lys Pro Asp Val Ile Ser Phe Leu Glu Gln Gly Lys Glu Pro           
80                  85                  90                  95            

tgg atg gtg gag aga gtg gtg tct gga ggc ctg tgt cca gta ttg gag        635
Trp Met Val Glu Arg Val Val Ser Gly Gly Leu Cys Pro Val Leu Glu           
                100                 105                 110               

tcc aga tat gat acc aag gaa tta ttt cca aag cag cat gtt tat gaa        683
Ser Arg Tyr Asp Thr Lys Glu Leu Phe Pro Lys Gln His Val Tyr Glu           
            115                 120                 125                   

gtc gaa tca ccc caa tgg gag ata atg gaa agc ctt aca agt tat ggt        731
Val Glu Ser Pro Gln Trp Glu Ile Met Glu Ser Leu Thr Ser Tyr Gly           
        130                 135                 140                       

ctt gag tgt tca agt ttc caa gat gat tgg gaa tgc aga aac cag ttt        779
Leu Glu Cys Ser Ser Phe Gln Asp Asp Trp Glu Cys Arg Asn Gln Phe           
    145                 150                 155                           

gac aga caa cag gga aat cca gac aga cat ttc cat cag atg atc atc        827
Asp Arg Gln Gln Gly Asn Pro Asp Arg His Phe His Gln Met Ile Ile           
160                 165                 170                 175           

aga cat gaa gaa atg ccc act ttt gac cag cat gca tcc ctt act ttt        875
Arg His Glu Glu Met Pro Thr Phe Asp Gln His Ala Ser Leu Thr Phe           
                180                 185                 190               

tat cag aaa att cat act aga gaa aaa cct ttt ggg tat aat aaa tgt        923
Tyr Gln Lys Ile His Thr Arg Glu Lys Pro Phe Gly Tyr Asn Lys Cys           
            195                 200                 205                   

aga aaa gac ttc tgg caa aag gaa ctc ctt att aat cat caa gga att        971
Arg Lys Asp Phe Trp Gln Lys Glu Leu Leu Ile Asn His Gln Gly Ile           
        210                 215                 220                       

tat act aat gag aaa ccc tat aaa tgt aag gaa tgt ggg aag gcc ttt       1019
Tyr Thr Asn Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe           
    225                 230                 235                           

aaa tat ggc tca cga cta att caa cat gag aat att cat tct ggt aag       1067
Lys Tyr Gly Ser Arg Leu Ile Gln His Glu Asn Ile His Ser Gly Lys           
240                 245                 250                 255           

aaa cca tat gaa tgt aag gaa tgt gga aag gcc ttc aat tct ggt tca       1115
Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Asn Ser Gly Ser           
                260                 265                 270               

aat ttt ata caa cat cag aga gtt cat act ggt gag aaa ccg tat gaa       1163
Asn Phe Ile Gln His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Glu           
            275                 280                 285                   

tgt aaa gat tgt gag aag gcc ttt agt cga agc tca cag ttg att gaa       1211
Cys Lys Asp Cys Glu Lys Ala Phe Ser Arg Ser Ser Gln Leu Ile Glu           
        290                 295                 300                       

cat cag cga act cac aca ggc gag aaa ccc tat cag tgt aag gaa tgt       1259
His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Gln Cys Lys Glu Cys           
    305                 310                 315                           

ggc aag gcc ttc aat cgg atc tca cat ctt aaa gta cat tat aga att       1307
Gly Lys Ala Phe Asn Arg Ile Ser His Leu Lys Val His Tyr Arg Ile           
320                 325                 330                 335           

cat act ggt gaa aaa ccc tat gca tgc aag gaa tgt ggg aaa acc ttt       1355
His Thr Gly Glu Lys Pro Tyr Ala Cys Lys Glu Cys Gly Lys Thr Phe           
                340                 345                 350               

agt cat cgt tct cag ttg att caa cat cag act gtt cat act ggc agg       1403
Ser His Arg Ser Gln Leu Ile Gln His Gln Thr Val His Thr Gly Arg           
            355                 360                 365                   

aaa ctc tat gaa tgt aag gaa tgt ggg aag gct ttt aat caa ggc tca       1451
Lys Leu Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Asn Gln Gly Ser           
        370                 375                 380                       

act ctt ata cga cat cag aga att cat acc ggt gag aaa ccc tat gag       1499
Thr Leu Ile Arg His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu           
    385                 390                 395                           

tgc aaa gta tgt gga aag gcc ttt aga gtg agc tca caa ctc aag caa       1547
Cys Lys Val Cys Gly Lys Ala Phe Arg Val Ser Ser Gln Leu Lys Gln           
400                 405                 410                 415           

cat cag aga att cac act gga gag aaa ccc tac caa tgt aag gta tgt       1595
His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Lys Val Cys           
                420                 425                 430               

ggt agg gcc ttc aaa cgg gtc tca cat ctt act gta cat tac aga att       1643
Gly Arg Ala Phe Lys Arg Val Ser His Leu Thr Val His Tyr Arg Ile           
            435                 440                 445                   

cat aca ggt gaa aag cca tat gaa tgt aag gaa tgt ggg aag gct ttt       1691
His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe           
        450                 455                 460                       

agt cat tgc tca caa ttg att cat cat cag gtt att cac act gag aaa       1739
Ser His Cys Ser Gln Leu Ile His His Gln Val Ile His Thr Glu Lys           
    465                 470                 475                           

aag ccc tat gaa tat aag gaa tgt gag aag acc ttg agt cat gat tca       1787
Lys Pro Tyr Glu Tyr Lys Glu Cys Glu Lys Thr Leu Ser His Asp Ser           
480                 485                 490                 495           

act acc gtt caa cct cag aga atg cat aat aga gaa aca cat gtg aat       1835
Thr Thr Val Gln Pro Gln Arg Met His Asn Arg Glu Thr His Val Asn           
                500                 505                 510               

ata ata aat gta gaa aag cct tcc atc agc agt tac ccc tta cta atc       1883
Ile Ile Asn Val Glu Lys Pro Ser Ile Ser Ser Tyr Pro Leu Leu Ile           
            515                 520                 525                   

atc aga gaa ttt atg ttg gca agc aac cat atg aat gga agt aat ggg       1931
Ile Arg Glu Phe Met Leu Ala Ser Asn His Met Asn Gly Ser Asn Gly           
        530                 535                 540                       

gaa agc cca tta gcc tag gctaattgtg actgtgactt acttctccct              1979
Glu Ser Pro Leu Ala                                                       
    545                                                                   

cttggagaaa gacttgaaga atgtaatgcc agtgacaatg ccttcattca gaggtaagcc     2039

tttatcctaa gtctgaaaat tcatatcaaa gaaaatttta tggatgtaaa ttgttcagat     2099

cataattgtc aaaaatgctg ggaaaggttg ggagaaattt tatttctaac acattccaga     2159

accacatttt ctaaccacag tgtagtaatt ttatcaagag caaaagttat agttttctta     2219

caagttaaaa aaacagccag attatcattt gcttaacaaa gaaatcatgc aattaccata     2279

aatggtaatg aaaagaatga attgagagtt taacatgcca agagatgtga aatgtggcca     2339

aagagatgtg agggtaaggg gaaagccaaa gctacactgg aggaattttt atagcctttg     2399

aatgcatgca tatacatgaa aatctgaaag ataaactcat atgcactaaa catgctattc     2459

aagtctacca aacatccagg cagtgaaaga agaaagtaac agaaaatgat gaaataaaga     2519

gaccatctta caataatctc agtttttgtt tctttctgat ccagaaataa tctaaattta     2579

ggagaatatt tcttaatttc cacattgtta cattgtttta tgtgactggc acagacaacc     2639

attggttgtc atcccagcag ccatacccaa ttccccttgt tattggcagc atctgtgtct     2699

tgccttggac tctgagaata tcagatgcta attttccagt ctcctgtgca gcacagtatg     2759

gccagtatct cccagtgttg ctcagtggaa tctgccgggg cttctgggaa agattttcct     2819

cattcagaag agacaggttt atcatgaaga cttcctcctc tctcacttcc tgcttttaaa     2879

catttttata taagaacatg atgcctgaag ctgctgcagc tgtcttggaa ccaagaagag     2939

aaaaaagtgg acctcagaga agctgaccca gagcctgaga agactcagct actaggccaa     2999

ttctggaact gcctttttga tgccttgtta tctgagaaaa ataaaacttg attgctcagt     3059

ta                                                                    3061


<210>  66
<211>  548
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Asp Pro Leu Ala Leu Pro Ser Gln Asp Ser Ala Leu Pro Gln Glu 
1               5                   10                  15      


Arg Asn Gln Lys Glu Asp Leu Ser Ala Leu Glu Ile Leu Lys Val Met 
            20                  25                  30          


Ser Leu Gly Ser Glu Leu Phe Arg Asp Val Ala Ile Val Phe Ser Gln 
        35                  40                  45              


Glu Glu Trp Gln Trp Leu Ala Pro Ala Gln Arg Asp Leu Tyr Arg Asp 
    50                  55                  60                  


Val Met Leu Glu Thr Tyr Ser Asn Leu Val Ser Leu Gly Leu Ala Val 
65                  70                  75                  80  


Ser Lys Pro Asp Val Ile Ser Phe Leu Glu Gln Gly Lys Glu Pro Trp 
                85                  90                  95      


Met Val Glu Arg Val Val Ser Gly Gly Leu Cys Pro Val Leu Glu Ser 
            100                 105                 110         


Arg Tyr Asp Thr Lys Glu Leu Phe Pro Lys Gln His Val Tyr Glu Val 
        115                 120                 125             


Glu Ser Pro Gln Trp Glu Ile Met Glu Ser Leu Thr Ser Tyr Gly Leu 
    130                 135                 140                 


Glu Cys Ser Ser Phe Gln Asp Asp Trp Glu Cys Arg Asn Gln Phe Asp 
145                 150                 155                 160 


Arg Gln Gln Gly Asn Pro Asp Arg His Phe His Gln Met Ile Ile Arg 
                165                 170                 175     


His Glu Glu Met Pro Thr Phe Asp Gln His Ala Ser Leu Thr Phe Tyr 
            180                 185                 190         


Gln Lys Ile His Thr Arg Glu Lys Pro Phe Gly Tyr Asn Lys Cys Arg 
        195                 200                 205             


Lys Asp Phe Trp Gln Lys Glu Leu Leu Ile Asn His Gln Gly Ile Tyr 
    210                 215                 220                 


Thr Asn Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Ala Phe Lys 
225                 230                 235                 240 


Tyr Gly Ser Arg Leu Ile Gln His Glu Asn Ile His Ser Gly Lys Lys 
                245                 250                 255     


Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Asn Ser Gly Ser Asn 
            260                 265                 270         


Phe Ile Gln His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Glu Cys 
        275                 280                 285             


Lys Asp Cys Glu Lys Ala Phe Ser Arg Ser Ser Gln Leu Ile Glu His 
    290                 295                 300                 


Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Gln Cys Lys Glu Cys Gly 
305                 310                 315                 320 


Lys Ala Phe Asn Arg Ile Ser His Leu Lys Val His Tyr Arg Ile His 
                325                 330                 335     


Thr Gly Glu Lys Pro Tyr Ala Cys Lys Glu Cys Gly Lys Thr Phe Ser 
            340                 345                 350         


His Arg Ser Gln Leu Ile Gln His Gln Thr Val His Thr Gly Arg Lys 
        355                 360                 365             


Leu Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Asn Gln Gly Ser Thr 
    370                 375                 380                 


Leu Ile Arg His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys 
385                 390                 395                 400 


Lys Val Cys Gly Lys Ala Phe Arg Val Ser Ser Gln Leu Lys Gln His 
                405                 410                 415     


Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Lys Val Cys Gly 
            420                 425                 430         


Arg Ala Phe Lys Arg Val Ser His Leu Thr Val His Tyr Arg Ile His 
        435                 440                 445             


Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ser 
    450                 455                 460                 


His Cys Ser Gln Leu Ile His His Gln Val Ile His Thr Glu Lys Lys 
465                 470                 475                 480 


Pro Tyr Glu Tyr Lys Glu Cys Glu Lys Thr Leu Ser His Asp Ser Thr 
                485                 490                 495     


Thr Val Gln Pro Gln Arg Met His Asn Arg Glu Thr His Val Asn Ile 
            500                 505                 510         


Ile Asn Val Glu Lys Pro Ser Ile Ser Ser Tyr Pro Leu Leu Ile Ile 
        515                 520                 525             


Arg Glu Phe Met Leu Ala Ser Asn His Met Asn Gly Ser Asn Gly Glu 
    530                 535                 540                 


Ser Pro Leu Ala 
545             


