                               SEQUENCE LISTING

<110> MEMORIAL SLOAN KETTERING CANCER CENTER
 
<120> MULTIMERIZATION OF IL-15/IL-15R-ALPHA-FC COMPLEXES TO ENHANCE 
      IMMUNOTHERAPY

<130> 115872-9025

<140> PCT/US2020/013232
<141> 2020-01-10

<150> 62/791,678
<151> 2019-01-11

<160> 53    

<170> PatentIn version 3.5

<210> 1
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
            20                  25                  30          


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
        35                  40                  45              


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
    50                  55                  60                  


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
65                  70                  75                  80  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
                85                  90                  95      


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
            100                 105                 110         


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
        115                 120                 125             


Thr Ser 
    130 


<210> 2
<211> 424
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
            20                  25                  30          


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
        35                  40                  45              


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
    50                  55                  60                  


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
65                  70                  75                  80  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
                85                  90                  95      


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
            100                 105                 110         


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
        115                 120                 125             


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
    130                 135                 140                 


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
145                 150                 155                 160 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
                165                 170                 175     


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Ala 
            180                 185                 190         


Ser Thr Lys Gly Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        195                 200                 205             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    210                 215                 220                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
225                 230                 235                 240 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                245                 250                 255     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            260                 265                 270         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        275                 280                 285             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    290                 295                 300                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
305                 310                 315                 320 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                325                 330                 335     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            340                 345                 350         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        355                 360                 365             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    370                 375                 380                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
385                 390                 395                 400 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                405                 410                 415     


Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 


<210> 3
<211> 393
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggcaa ctgggtcaac       60

gtgatctccg acctgaagaa gatcgaggac ctgatccagt ccatgcacat cgacgccacc      120

ctgtacaccg agtccgacgt gcacccctcc tgcaaagtga ccgccatgaa gtgctttctg      180

ctggaactgc aagtgatctc cctggaatcc ggcgacgcct ccatccacga caccgtggaa      240

aatctgatca tcctggccaa caactccctg tcctccaacg gcaacgtgac cgagagcggc      300

tgcaaagagt gcgaggaact ggaagagaag aacatcaaag agtttctgca gtccttcgtg      360

cacatcgtgc agatgttcat caacaccagc tag                                   393


<210> 4
<211> 1275
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
atgggctggt cctgcatcat cctgtttctg gtggccacag ccaccggcat cacctgtcct       60

ccacccatgt ctgtggaaca cgccgacatc tgggtcaagt cctactccct gtactccaga      120

gagcggtaca tctgcaactc cggcttcaag cggaaggccg gcacctctag cctgaccgag      180

tgcgtgctga acaaggccac caacgtggcc cactggacca ccccatccct gaagtgcatc      240

agggaccctg ccctggtgca tcagaggcct gctcctccat ccaccgtgac cacagctggc      300

gtgacccctc agcctgagtc cctgagccct tccggcaaag agccagccgc ctcctcccct      360

tcctctaaca ataccgccgc taccaccgcc gccatcgtgc ctggatctca gctgatgccc      420

tccaagtccc cttccaccgg aaccaccgag atctccagcc acgagtcctc tcacggcacc      480

ccttctcaga ccaccgccaa gaactgggag ctgaccgcct ctgcctctca ccagcctcca      540

ggcgtgtacc ctcagggcca ctctgacacc accgcctcta caaagggccc agacaaaact      600

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc      660

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      720

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag      780

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc      840

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc      900

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc      960

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1020

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1080

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1140

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1200

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1260

tctccgggta aatga                                                      1275


<210> 5
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
            20                  25                  30          


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
        35                  40                  45              


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
    50                  55                  60                  


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
65                  70                  75                  80  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
                85                  90                  95      


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
            100                 105                 110         


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
        115                 120                 125             


Thr Ser 
    130 


<210> 6
<211> 424
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
            20                  25                  30          


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
        35                  40                  45              


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
    50                  55                  60                  


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
65                  70                  75                  80  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
                85                  90                  95      


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
            100                 105                 110         


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
        115                 120                 125             


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
    130                 135                 140                 


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
145                 150                 155                 160 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
                165                 170                 175     


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Ala 
            180                 185                 190         


Ser Thr Lys Gly Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        195                 200                 205             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    210                 215                 220                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
225                 230                 235                 240 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                245                 250                 255     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            260                 265                 270         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        275                 280                 285             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    290                 295                 300                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
305                 310                 315                 320 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                325                 330                 335     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            340                 345                 350         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        355                 360                 365             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    370                 375                 380                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
385                 390                 395                 400 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                405                 410                 415     


Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 


<210> 7
<211> 393
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
atgggctggt cctgcatcat cctgtttctg gtggccaccg ccaccggcaa ctgggtcaac       60

gtgatctccg acctgaagaa gatcgaggac ctgatccagt ccatgcacat cgacgccacc      120

ctgtacaccg agtccgacgt gcacccctcc tgcaaagtga ccgccatgaa gtgctttctg      180

ctggaactgc aagtgatctc cctggaatcc ggcgacgcct ccatccacga caccgtggaa      240

aatctgatca tcctggccaa cgactccctg tcctccaacg gcaacgtgac cgagagcggc      300

tgcaaagagt gcgaggaact ggaagagaag aacatcaaag agtttctgca gtccttcgtg      360

cacatcgtgc agatgttcat caacaccagc tag                                   393


<210> 8
<211> 1275
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggcat cacctgtcct       60

ccacccatgt ctgtggaaca cgccgacatc tgggtcaagt cctactccct gtactccaga      120

gagcggtaca tctgcaactc cggcttcaag cggaaggccg gcacctctag cctgaccgag      180

tgcgtgctga acaaggccac caacgtggcc cactggacca ccccatccct gaagtgcatc      240

agggaccctg ccctggtgca tcagaggcct gctcctccat ccaccgtgac cacagctggc      300

gtgacccctc agcctgagtc cctgagccct tccggcaaag agccagccgc ctcctcccct      360

tcctctaaca ataccgccgc taccaccgcc gccatcgtgc ctggatctca gctgatgccc      420

tccaagtccc cttccaccgg aaccaccgag atctccagcc acgagtcctc tcacggcacc      480

ccttctcaga ccaccgccaa gaactgggag ctgaccgcct ctgcctctca ccagcctcca      540

ggcgtgtacc ctcagggcca ctctgacacc accgcctcta caaagggccc agacaaaact      600

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc      660

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      720

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag      780

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc      840

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc      900

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc      960

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1020

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1080

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1140

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1200

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1260

tctccgggta aatga                                                      1275


<210> 9
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
            20                  25                  30          


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
        35                  40                  45              


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
    50                  55                  60                  


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
65                  70                  75                  80  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
                85                  90                  95      


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
            100                 105                 110         


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
        115                 120                 125             


Thr Ser 
    130 


<210> 10
<211> 313
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
            20                  25                  30          


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
        35                  40                  45              


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
    50                  55                  60                  


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
65                  70                  75                  80  


Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                85                  90                  95      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            100                 105                 110         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        115                 120                 125             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    130                 135                 140                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
145                 150                 155                 160 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                165                 170                 175     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            180                 185                 190         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        195                 200                 205             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    210                 215                 220                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
225                 230                 235                 240 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                245                 250                 255     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            260                 265                 270         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        275                 280                 285             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    290                 295                 300                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
305                 310             


<210> 11
<211> 393
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggcaa ctgggtcaac       60

gtgatctccg acctgaagaa gatcgaggac ctgatccagt ccatgcacat cgacgccacc      120

ctgtacaccg agtccgacgt gcacccctcc tgcaaagtga ccgccatgaa gtgctttctg      180

ctggaactgc aagtgatctc cctggaatcc ggcgacgcct ccatccacga caccgtggaa      240

aatctgatca tcctggccaa caactccctg tcctccaacg gcaacgtgac cgagagcggc      300

tgcaaagagt gcgaggaact ggaagagaag aacatcaaag agtttctgca gtccttcgtg      360

cacatcgtgc agatgttcat caacaccagc tag                                   393


<210> 12
<211> 942
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggcat cacctgtcct       60

ccacccatgt ctgtggaaca cgccgacatc tgggtcaagt cctactccct gtactccaga      120

gagcggtaca tctgcaactc cggcttcaag cggaaggccg gcacctctag cctgaccgag      180

tgcgtgctga acaaggccac caacgtggcc cactggacca ccccatccct gaagtgcatc      240

agagagccca agtcctgcga caagacccac acctgtcccc cttgtcctgc ccctgaactg      300

ctgggcggac cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatctcc      360

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc agaagtgaag      420

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc cagagaggaa      480

cagtacaact ccacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggattggctg      540

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgcccc catcgaaaag      600

accatctcca aggccaaggg ccagccccgg gaaccccagg tgtacacact gccccctagc      660

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaggg cttctacccc      720

tccgatatcg ccgtggaatg ggagtccaac ggccagcctg agaacaacta caagaccacc      780

ccccctgtgc tggactccga cggctcattc ttcctgtaca gcaagctgac agtggacaag      840

tcccggtggc agcagggcaa cgtgttctcc tgctccgtga tgcacgaggc cctgcacaac      900

cactacacac agaagtccct gtccctgagc cccggcaaat ga                         942


<210> 13
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
            20                  25                  30          


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
        35                  40                  45              


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
    50                  55                  60                  


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
65                  70                  75                  80  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
                85                  90                  95      


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
            100                 105                 110         


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
        115                 120                 125             


Thr Ser 
    130 


<210> 14
<211> 313
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
            20                  25                  30          


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
        35                  40                  45              


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
    50                  55                  60                  


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
65                  70                  75                  80  


Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                85                  90                  95      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            100                 105                 110         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        115                 120                 125             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    130                 135                 140                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
145                 150                 155                 160 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                165                 170                 175     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            180                 185                 190         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        195                 200                 205             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    210                 215                 220                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
225                 230                 235                 240 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                245                 250                 255     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            260                 265                 270         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        275                 280                 285             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    290                 295                 300                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
305                 310             


<210> 15
<211> 393
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggcaa ctgggtcaac       60

gtgatctccg acctgaagaa gatcgaggac ctgatccagt ccatgcacat cgacgccacc      120

ctgtacaccg agtccgacgt gcacccctcc tgcaaagtga ccgccatgaa gtgctttctg      180

ctggaactgc aagtgatctc cctggaatcc ggcgacgcct ccatccacga caccgtggaa      240

aatctgatca tcctggccaa cgactccctg tcctccaacg gcaacgtgac cgagagcggc      300

tgcaaagagt gcgaggaact ggaagagaag aacatcaaag agtttctgca gtccttcgtg      360

cacatcgtgc agatgttcat caacaccagc tag                                   393


<210> 16
<211> 942
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggcat cacctgtcct       60

ccacccatgt ctgtggaaca cgccgacatc tgggtcaagt cctactccct gtactccaga      120

gagcggtaca tctgcaactc cggcttcaag cggaaggccg gcacctctag cctgaccgag      180

tgcgtgctga acaaggccac caacgtggcc cactggacca ccccatccct gaagtgcatc      240

agagagccca agtcctgcga caagacccac acctgtcccc cttgtcctgc ccctgaactg      300

ctgggcggac cttccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatctcc      360

cggacccccg aagtgacctg cgtggtggtg gatgtgtccc acgaggaccc agaagtgaag      420

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc cagagaggaa      480

cagtacaact ccacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggattggctg      540

aacggcaaag agtacaagtg caaggtgtcc aacaaggccc tgcctgcccc catcgaaaag      600

accatctcca aggccaaggg ccagccccgg gaaccccagg tgtacacact gccccctagc      660

agggacgagc tgaccaagaa ccaggtgtcc ctgacctgtc tcgtgaaggg cttctacccc      720

tccgatatcg ccgtggaatg ggagtccaac ggccagcctg agaacaacta caagaccacc      780

ccccctgtgc tggactccga cggctcattc ttcctgtaca gcaagctgac agtggacaag      840

tcccggtggc agcagggcaa cgtgttctcc tgctccgtga tgcacgaggc cctgcacaac      900

cactacacac agaagtccct gtccctgagc cccggcaaat ga                         942


<210> 17
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
            20                  25                  30          


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
        35                  40                  45              


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
    50                  55                  60                  


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
65                  70                  75                  80  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
                85                  90                  95      


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
            100                 105                 110         


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
        115                 120                 125             


Thr Ser 
    130 


<210> 18
<211> 424
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
            20                  25                  30          


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
        35                  40                  45              


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
    50                  55                  60                  


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
65                  70                  75                  80  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
                85                  90                  95      


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
            100                 105                 110         


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
        115                 120                 125             


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
    130                 135                 140                 


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
145                 150                 155                 160 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
                165                 170                 175     


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Ala 
            180                 185                 190         


Ser Thr Lys Gly Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        195                 200                 205             


Pro Glu Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro 
    210                 215                 220                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
225                 230                 235                 240 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                245                 250                 255     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            260                 265                 270         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        275                 280                 285             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    290                 295                 300                 


Leu Pro Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
305                 310                 315                 320 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                325                 330                 335     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            340                 345                 350         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        355                 360                 365             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    370                 375                 380                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
385                 390                 395                 400 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                405                 410                 415     


Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 


<210> 19
<211> 393
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
atgggctggt cctgcatcat cctgtttctg gtggccaccg ccaccggcaa ctgggtcaac       60

gtgatctccg acctgaagaa gatcgaggac ctgatccagt ccatgcacat cgacgccacc      120

ctgtacaccg agtccgacgt gcacccctcc tgcaaagtga ccgccatgaa gtgctttctg      180

ctggaactgc aagtgatctc cctggaatcc ggcgacgcct ccatccacga caccgtggaa      240

aatctgatca tcctggccaa cgactccctg tcctccaacg gcaacgtgac cgagagcggc      300

tgcaaagagt gcgaggaact ggaagagaag aacatcaaag agtttctgca gtccttcgtg      360

cacatcgtgc agatgttcat caacaccagc tag                                   393


<210> 20
<211> 1298
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 20
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggcat cacctgtcct       60

ccacccatgt ctgtggaaca cgccgacatc tgggtcaagt cctactccct gtactccaga      120

gagcggtaca tctgcaactc cggcttcaag cggaaggccg gcacctctag cctgaccgag      180

tgcgtgctga acaaggccac caacgtggcc cactggacca ccccatccct gaagtgcatc      240

agggaccctg ccctggtgca tcagaggcct gctcctccat ccaccgtgac cacagctggc      300

gtgacccctc agcctgagtc cctgagccct tccggcaaag agccagccgc ctcctcccct      360

tcctctaaca ataccgccgc taccaccgcc gccatcgtgc ctggatctca gctgatgccc      420

tccaagtccc cttccaccgg aaccaccgag atctccagcc acgagtcctc tcacggcacc      480

ccttctcaga ccaccgccaa gaactgggag ctgaccgcct ctgcctctca ccagcctcca      540

ggcgtgtacc ctcagggcca ctctgacacc accgcctcta caaagggccc agacaaaact      600

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccggacgt cttcctcttc      660

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      720

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag      780

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc      840

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc      900

tccaacaaag ccctcccact ccccgaggag aaaaccatct ccaaagccaa agggcagccc      960

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     1020

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     1080

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1140

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1200

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1260

tctccgggta aatgagtgcg acggccggca agggatcc                             1298


<210> 21
<211> 9
<212> PRT
<213> Human cytomegalovirus 

<400> 21
Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


<210> 22
<211> 9
<212> PRT
<213> Human cytomegalovirus 

<400> 22
Gln Tyr Asp Pro Val Ala Ala Leu Phe 
1               5                   


<210> 23
<211> 10
<212> PRT
<213> Human cytomegalovirus 

<400> 23
Thr Pro Arg Val Thr Gly Gly Gly Ala Met 
1               5                   10  


<210> 24
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Ala Ser Thr Lys Gly Pro 
1               5       


<210> 25
<211> 114
<212> PRT
<213> Homo sapiens

<400> 25
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 26
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 27
<211> 175
<212> PRT
<213> Homo sapiens

<400> 27
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                165                 170                 175 


<210> 28
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


<210> 29
<211> 227
<212> PRT
<213> Homo sapiens

<400> 29
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 30
<211> 228
<212> PRT
<213> Homo sapiens

<400> 30
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210> 31
<211> 279
<212> PRT
<213> Homo sapiens

<400> 31
Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro 
    50                  55                  60                  


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
65                  70                  75                  80  


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                85                  90                  95      


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp 
            100                 105                 110         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        115                 120                 125             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    130                 135                 140                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
145                 150                 155                 160 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                165                 170                 175     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            180                 185                 190         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        195                 200                 205             


Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn 
    210                 215                 220                 


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
225                 230                 235                 240 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser 
                245                 250                 255     


Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
            260                 265                 270         


Leu Ser Leu Ser Pro Gly Lys 
        275                 


<210> 32
<211> 229
<212> PRT
<213> Homo sapiens

<400> 32
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210> 33
<211> 425
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
            20                  25                  30          


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
        35                  40                  45              


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
    50                  55                  60                  


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
65                  70                  75                  80  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
                85                  90                  95      


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
            100                 105                 110         


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
        115                 120                 125             


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
    130                 135                 140                 


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
145                 150                 155                 160 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
                165                 170                 175     


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Ala 
            180                 185                 190         


Ser Thr Lys Gly Pro Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
        195                 200                 205             


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    210                 215                 220                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
225                 230                 235                 240 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
                245                 250                 255     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            260                 265                 270         


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
        275                 280                 285             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    290                 295                 300                 


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
305                 310                 315                 320 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                325                 330                 335     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            340                 345                 350         


Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        355                 360                 365             


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    370                 375                 380                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
385                 390                 395                 400 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                405                 410                 415     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425 


<210> 34
<211> 476
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
            20                  25                  30          


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
        35                  40                  45              


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
    50                  55                  60                  


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
65                  70                  75                  80  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
                85                  90                  95      


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
            100                 105                 110         


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
        115                 120                 125             


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
    130                 135                 140                 


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
145                 150                 155                 160 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
                165                 170                 175     


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Ala 
            180                 185                 190         


Ser Thr Lys Gly Pro Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His 
        195                 200                 205             


Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
    210                 215                 220                 


Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
225                 230                 235                 240 


Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
                245                 250                 255     


Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
    290                 295                 300                 


Lys Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg 
    450                 455                 460                 


Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210> 35
<211> 426
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
            20                  25                  30          


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
        35                  40                  45              


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
    50                  55                  60                  


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
65                  70                  75                  80  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
                85                  90                  95      


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
            100                 105                 110         


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
        115                 120                 125             


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
    130                 135                 140                 


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
145                 150                 155                 160 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
                165                 170                 175     


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Ala 
            180                 185                 190         


Ser Thr Lys Gly Pro Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys 
        195                 200                 205             


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    210                 215                 220                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
225                 230                 235                 240 


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
                245                 250                 255     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            260                 265                 270         


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        275                 280                 285             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    290                 295                 300                 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
305                 310                 315                 320 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
                325                 330                 335     


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            340                 345                 350         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        355                 360                 365             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    370                 375                 380                 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
385                 390                 395                 400 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                405                 410                 415     


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            420                 425     


<210> 36
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Ala Ser Thr Thr Ala Pro 
1               5       


<210> 37
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210> 38
<211> 114
<212> PRT
<213> Canis lupus 

<400> 38
Asn Trp Gln Asp Val Ile Leu Asp Leu Glu Lys Ile Asp Asn Leu Ile 
1               5                   10                  15      


Gln Ser Ile His Met Asp Thr Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gly 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Ser His Pro Ile Lys Glu Ala Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Ser Asp Leu Ser Ser Lys Gly Asn Ile 
65                  70                  75                  80  


Thr Glu Thr Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Ser Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Ser Ser 
        


<210> 39
<211> 193
<212> PRT
<213> Canis lupus 

<400> 39
Ile Thr Cys Pro Pro Pro Thr Ser Val Lys His Ala Asp Ile Gln Val 
1               5                   10                  15      


Lys Ser Tyr Ser Val Ser Ser Lys Glu Arg Tyr Thr Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Thr Thr Asn Thr Ala His Trp Thr Ile Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Ile Met Lys His Ser Ser Phe His Pro Gln Ala His Lys Cys His Val 
65                  70                  75                  80  


Val Ile Leu Ser Pro Gly Asp Pro Ser Leu Thr His Leu Arg Pro Ser 
                85                  90                  95      


Ser Ser Asp Val Pro Ala Gly Val Thr Pro Glu Pro Glu Ser Thr Ser 
            100                 105                 110         


Leu Ser Gly Lys Glu Pro Thr Phe Thr Ser Lys Ser Asp Thr Lys Val 
        115                 120                 125             


Ala Thr Lys Pro Thr Ile Val Pro Gly Ser Arg Pro Met Pro Ser Lys 
    130                 135                 140                 


Pro Pro Ala Thr Gly Thr Thr Gly Leu Ile Ser Asn Glu Pro Ser Ser 
145                 150                 155                 160 


Gln Ala Pro Ser Gln Thr Thr Ala Lys Ala Leu Glu His Thr Pro Ser 
                165                 170                 175     


Ala Ser Gln Glu Thr Pro Gly Thr Tyr Ser Tyr Asn Ser Gly Ala Val 
            180                 185                 190         


Thr 
    


<210> 40
<211> 237
<212> PRT
<213> Canis lupus 

<400> 40
Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser 
    50                  55                  60                  


Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile 
                85                  90                  95      


Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn 
            100                 105                 110         


Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg 
        115                 120                 125             


Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe 
145                 150                 155                 160 


Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu 
                165                 170                 175     


Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly 
            180                 185                 190         


Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
225                 230                 235         


<210> 41
<211> 233
<212> PRT
<213> Canis lupus 

<400> 41
Phe Asn Glu Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu 
1               5                   10                  15      


Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp 
            20                  25                  30          


Ile Leu Arg Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp 
        35                  40                  45              


Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
    50                  55                  60                  


Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn 
65                  70                  75                  80  


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp 
                85                  90                  95      


Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro 
            100                 105                 110         


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys 
        115                 120                 125             


Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser 
    130                 135                 140                 


Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp 
145                 150                 155                 160 


Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys 
                165                 170                 175     


His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro 
        195                 200                 205             


Phe Thr Cys Ala Val Met His Glu Thr Leu Gln Asn His Tyr Thr Asp 
    210                 215                 220                 


Leu Ser Leu Ser His Ser Pro Gly Lys 
225                 230             


<210> 42
<211> 235
<212> PRT
<213> Canis lupus 

<400> 42
Ala Lys Glu Cys Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro Cys Pro 
1               5                   10                  15      


Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
                85                  90                  95      


Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly Gln 
        115                 120                 125             


Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Met 
    130                 135                 140                 


Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe Pro 
145                 150                 155                 160 


Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
                165                 170                 175     


Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
        195                 200                 205             


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
225                 230                 235 


<210> 43
<211> 233
<212> PRT
<213> Canis lupus 

<400> 43
Pro Lys Glu Ser Thr Cys Lys Cys Ile Ser Pro Cys Pro Val Pro Glu 
1               5                   10                  15      


Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
            20                  25                  30          


Ile Leu Arg Ile Thr Arg Thr Pro Glu Ile Thr Cys Val Val Leu Asp 
        35                  40                  45              


Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
    50                  55                  60                  


Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu Gln Gln Phe Asn 
65                  70                  75                  80  


Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp 
                85                  90                  95      


Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His Ile Gly Leu Pro 
            100                 105                 110         


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
        115                 120                 125             


Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser 
    130                 135                 140                 


Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Glu 
145                 150                 155                 160 


Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu Pro Glu Ser Lys 
                165                 170                 175     


Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Thr 
        195                 200                 205             


Phe Thr Cys Ala Val Met His Glu Ala Leu Gln Asn His Tyr Thr Asp 
    210                 215                 220                 


Leu Ser Leu Ser His Ser Pro Gly Lys 
225                 230             


<210> 44
<211> 133
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asn Trp Gln Asp Val Ile Leu Asp Leu Glu Lys Ile Asp 
            20                  25                  30          


Asn Leu Ile Gln Ser Ile His Met Asp Thr Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gly Val Ile Ser Leu Glu Ser Gly Ser His Pro Ile Lys Glu 
65                  70                  75                  80  


Ala Val Glu Asn Leu Ile Ile Leu Ala Asn Ser Asp Leu Ser Ser Lys 
                85                  90                  95      


Gly Asn Ile Thr Glu Thr Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Ser Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Ser Ser 
    130             


<210> 45
<211> 455
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ile Thr Cys Pro Pro Pro Thr Ser Val Lys His Ala Asp 
            20                  25                  30          


Ile Gln Val Lys Ser Tyr Ser Val Ser Ser Lys Glu Arg Tyr Thr Cys 
        35                  40                  45              


Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys 
    50                  55                  60                  


Val Leu Asn Lys Thr Thr Asn Thr Ala His Trp Thr Ile Pro Ser Leu 
65                  70                  75                  80  


Lys Cys Ile Ile Met Lys His Ser Ser Phe His Pro Gln Ala His Lys 
                85                  90                  95      


Cys His Val Val Ile Leu Ser Pro Gly Asp Pro Ser Leu Thr His Leu 
            100                 105                 110         


Arg Pro Ser Ser Ser Asp Val Pro Ala Gly Val Thr Pro Glu Pro Glu 
        115                 120                 125             


Ser Thr Ser Leu Ser Gly Lys Glu Pro Thr Phe Thr Ser Lys Ser Asp 
    130                 135                 140                 


Thr Lys Val Ala Thr Lys Pro Thr Ile Val Pro Gly Ser Arg Pro Met 
145                 150                 155                 160 


Pro Ser Lys Pro Pro Ala Thr Gly Thr Thr Gly Leu Ile Ser Asn Glu 
                165                 170                 175     


Pro Ser Ser Gln Ala Pro Ser Gln Thr Thr Ala Lys Ala Leu Glu His 
            180                 185                 190         


Thr Pro Ser Ala Ser Gln Glu Thr Pro Gly Thr Tyr Ser Tyr Asn Ser 
        195                 200                 205             


Gly Ala Val Thr Ala Ser Thr Thr Ala Pro Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210> 46
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ile Thr Cys Pro Pro Pro Thr Ser Val Lys His Ala Asp 
            20                  25                  30          


Ile Gln Val Lys Ser Tyr Ser Val Ser Ser Lys Glu Arg Tyr Thr Cys 
        35                  40                  45              


Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys 
    50                  55                  60                  


Val Leu Asn Lys Thr Thr Asn Thr Ala His Trp Thr Ile Pro Ser Leu 
65                  70                  75                  80  


Lys Cys Ile Ile Met Lys His Ser Ser Phe His Pro Gln Ala His Lys 
                85                  90                  95      


Cys His Val Val Ile Leu Ser Pro Gly Asp Pro Ser Leu Thr His Leu 
            100                 105                 110         


Arg Pro Ser Ser Ser Asp Val Pro Ala Gly Val Thr Pro Glu Pro Glu 
        115                 120                 125             


Ser Thr Ser Leu Ser Gly Lys Glu Pro Thr Phe Thr Ser Lys Ser Asp 
    130                 135                 140                 


Thr Lys Val Ala Thr Lys Pro Thr Ile Val Pro Gly Ser Arg Pro Met 
145                 150                 155                 160 


Pro Ser Lys Pro Pro Ala Thr Gly Thr Thr Gly Leu Ile Ser Asn Glu 
                165                 170                 175     


Pro Ser Ser Gln Ala Pro Ser Gln Thr Thr Ala Lys Ala Leu Glu His 
            180                 185                 190         


Thr Pro Ser Ala Ser Gln Glu Thr Pro Gly Thr Tyr Ser Tyr Asn Ser 
        195                 200                 205             


Gly Ala Val Thr Ala Ser Thr Thr Ala Pro Phe Asn Glu Cys Arg Cys 
    210                 215                 220                 


Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr Ala 
        275                 280                 285             


Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu Phe 
305                 310                 315                 320 


Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg Thr 
                325                 330                 335     


Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val Leu 
            340                 345                 350         


Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val Met 
            420                 425                 430         


His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210> 47
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ile Thr Cys Pro Pro Pro Thr Ser Val Lys His Ala Asp 
            20                  25                  30          


Ile Gln Val Lys Ser Tyr Ser Val Ser Ser Lys Glu Arg Tyr Thr Cys 
        35                  40                  45              


Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys 
    50                  55                  60                  


Val Leu Asn Lys Thr Thr Asn Thr Ala His Trp Thr Ile Pro Ser Leu 
65                  70                  75                  80  


Lys Cys Ile Ile Met Lys His Ser Ser Phe His Pro Gln Ala His Lys 
                85                  90                  95      


Cys His Val Val Ile Leu Ser Pro Gly Asp Pro Ser Leu Thr His Leu 
            100                 105                 110         


Arg Pro Ser Ser Ser Asp Val Pro Ala Gly Val Thr Pro Glu Pro Glu 
        115                 120                 125             


Ser Thr Ser Leu Ser Gly Lys Glu Pro Thr Phe Thr Ser Lys Ser Asp 
    130                 135                 140                 


Thr Lys Val Ala Thr Lys Pro Thr Ile Val Pro Gly Ser Arg Pro Met 
145                 150                 155                 160 


Pro Ser Lys Pro Pro Ala Thr Gly Thr Thr Gly Leu Ile Ser Asn Glu 
                165                 170                 175     


Pro Ser Ser Gln Ala Pro Ser Gln Thr Thr Ala Lys Ala Leu Glu His 
            180                 185                 190         


Thr Pro Ser Ala Ser Gln Glu Thr Pro Gly Thr Tyr Ser Tyr Asn Ser 
        195                 200                 205             


Gly Ala Val Thr Ala Ser Thr Thr Ala Pro Ala Lys Glu Cys Glu Cys 
    210                 215                 220                 


Lys Cys Asn Cys Asn Asn Cys Pro Cys Pro Gly Cys Gly Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Val 
                245                 250                 255     


Thr Ala Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Leu Asp Pro 
            260                 265                 270         


Glu Asn Pro Glu Val Gln Ile Ser Trp Phe Val Asp Ser Lys Gln Val 
        275                 280                 285             


Gln Thr Ala Asn Thr Gln Pro Arg Glu Glu Gln Ser Asn Gly Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Ser Gly 
305                 310                 315                 320 


Lys Gln Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Glu Ile Ile Ser Lys Thr Pro Gly Gln Ala His Gln Pro Asn Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Ser Arg Asp Glu Met Ser Lys Asn Thr Val Thr 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Asp Phe Phe Pro Pro Glu Ile Asp Val Glu 
    370                 375                 380                 


Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Met Thr 
385                 390                 395                 400 


Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Ile Ser Leu Ser 
        435                 440                 445             


His Ser Pro Gly Lys 
    450             


<210> 48
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ile Thr Cys Pro Pro Pro Thr Ser Val Lys His Ala Asp 
            20                  25                  30          


Ile Gln Val Lys Ser Tyr Ser Val Ser Ser Lys Glu Arg Tyr Thr Cys 
        35                  40                  45              


Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys 
    50                  55                  60                  


Val Leu Asn Lys Thr Thr Asn Thr Ala His Trp Thr Ile Pro Ser Leu 
65                  70                  75                  80  


Lys Cys Ile Ile Met Lys His Ser Ser Phe His Pro Gln Ala His Lys 
                85                  90                  95      


Cys His Val Val Ile Leu Ser Pro Gly Asp Pro Ser Leu Thr His Leu 
            100                 105                 110         


Arg Pro Ser Ser Ser Asp Val Pro Ala Gly Val Thr Pro Glu Pro Glu 
        115                 120                 125             


Ser Thr Ser Leu Ser Gly Lys Glu Pro Thr Phe Thr Ser Lys Ser Asp 
    130                 135                 140                 


Thr Lys Val Ala Thr Lys Pro Thr Ile Val Pro Gly Ser Arg Pro Met 
145                 150                 155                 160 


Pro Ser Lys Pro Pro Ala Thr Gly Thr Thr Gly Leu Ile Ser Asn Glu 
                165                 170                 175     


Pro Ser Ser Gln Ala Pro Ser Gln Thr Thr Ala Lys Ala Leu Glu His 
            180                 185                 190         


Thr Pro Ser Ala Ser Gln Glu Thr Pro Gly Thr Tyr Ser Tyr Asn Ser 
        195                 200                 205             


Gly Ala Val Thr Ala Ser Thr Thr Ala Pro Pro Lys Glu Ser Thr Cys 
    210                 215                 220                 


Lys Cys Ile Ser Pro Cys Pro Val Pro Glu Ser Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr Arg 
                245                 250                 255     


Thr Pro Glu Ile Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr Ala 
        275                 280                 285             


Lys Thr Gln Pro Arg Glu Gln Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu Phe 
305                 310                 315                 320 


Lys Cys Arg Val Asn His Ile Gly Leu Pro Ser Pro Ile Glu Arg Thr 
                325                 330                 335     


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
            340                 345                 350         


Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Thr Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Glu Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Pro Glu Ser Lys Tyr His Thr Thr Ala Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asp Thr Phe Thr Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210> 49
<211> 114
<212> PRT
<213> Macaca mulatta

<400> 49
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser His Glu Ser Gly Asp Thr Asp Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ile Leu Ser Ser Asn Gly Asn Ile 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 50
<211> 174
<212> PRT
<213> Macaca mulatta

<400> 50
Ile Thr Cys Pro Pro Pro Val Ser Val Glu His Ala Asp Ile Arg Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Ile Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Leu Leu Ala Arg Gln Arg Pro Ala Leu Pro Phe Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Thr Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Ser Ser Arg Leu Met Pro Ser Thr Ser Ser 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Gly Ser His Glu Ser Ser His Gly Pro 
    130                 135                 140                 


Ser Gln Thr Thr Ala Lys Thr Trp Glu Leu Thr Ala Ser Ala Ser His 
145                 150                 155                 160 


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                165                 170                 


<210> 51
<211> 235
<212> PRT
<213> Macaca mulatta

<400> 51
Glu Ile Lys Thr Cys Gly Gly Gly Ser Lys Pro Pro Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Asp Val Lys Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asn Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Thr Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Thr His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Ala Leu Pro Ala Pro Ile Gln Lys Thr Ile Ser Lys Asp Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Val Val Glu Trp Glu Ser Ser Gly Gln Pro Glu 
                165                 170                 175     


Asn Thr Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Tyr 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235 


<210> 52
<211> 133
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu 
            20                  25                  30          


Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser 
        35                  40                  45              


Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu 
    50                  55                  60                  


Glu Leu Gln Val Ile Ser His Glu Ser Gly Asp Thr Asp Ile His Asp 
65                  70                  75                  80  


Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ile Leu Ser Ser Asn 
                85                  90                  95      


Gly Asn Ile Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu 
            100                 105                 110         


Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met 
        115                 120                 125             


Phe Ile Asn Thr Ser 
    130             


<210> 53
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Ile Thr Cys Pro Pro Pro Val Ser Val Glu His Ala Asp 
            20                  25                  30          


Ile Arg Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys 
        35                  40                  45              


Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys 
    50                  55                  60                  


Val Leu Asn Lys Ala Thr Asn Ile Ala His Trp Thr Thr Pro Ser Leu 
65                  70                  75                  80  


Lys Cys Ile Arg Asp Pro Leu Leu Ala Arg Gln Arg Pro Ala Leu Pro 
                85                  90                  95      


Phe Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser 
            100                 105                 110         


Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Thr Thr 
        115                 120                 125             


Ala Ala Thr Thr Ala Ala Ile Val Pro Ser Ser Arg Leu Met Pro Ser 
    130                 135                 140                 


Thr Ser Ser Ser Thr Gly Thr Thr Glu Ile Gly Ser His Glu Ser Ser 
145                 150                 155                 160 


His Gly Pro Ser Gln Thr Thr Ala Lys Thr Trp Glu Leu Thr Ala Ser 
                165                 170                 175     


Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr 
            180                 185                 190         


Thr Ala Ser Thr Lys Gly Pro Glu Ile Lys Thr Cys Gly Gly Gly Ser 
        195                 200                 205             


Lys Pro Pro Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    210                 215                 220                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
225                 230                 235                 240 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
                245                 250                 255     


Asp Pro Asp Val Lys Phe Asn Trp Tyr Val Asn Gly Ala Glu Val His 
            260                 265                 270         


His Ala Gln Thr Lys Pro Arg Glu Thr Gln Tyr Asn Ser Thr Tyr Arg 
        275                 280                 285             


Val Val Ser Val Leu Thr Val Thr His Gln Asp Trp Leu Asn Gly Lys 
    290                 295                 300                 


Glu Tyr Thr Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Gln 
305                 310                 315                 320 


Lys Thr Ile Ser Lys Asp Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                325                 330                 335     


Thr Leu Pro Pro Ser Arg Glu Glu Leu Thr Lys Asn Gln Val Ser Leu 
            340                 345                 350         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Val Val Glu Trp 
        355                 360                 365             


Glu Ser Ser Gly Gln Pro Glu Asn Thr Tyr Lys Thr Thr Pro Pro Val 
    370                 375                 380                 


Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Thr Val Asp 
385                 390                 395                 400 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                405                 410                 415     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            420                 425                 430         


Gly Lys 
        


