                         SEQUENCE LISTING

<110>  Malek, Thomas
 
<120>  METHODS OF USING IL-2/CD25 FUSION PROTEIN

<130>  32286/53839

<150>  US 62/791,713
<151>  2019-01-11

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  153
<212>  PRT
<213>  Homo sapeins

<400>  1

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  2
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  3
<211>  169
<212>  PRT
<213>  Mus musculus

<400>  3

Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln 
                165                 


<210>  4
<211>  169
<212>  PRT
<213>  Mus musculus

<400>  4

Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln 
                165                 


<210>  5
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         


<210>  6
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly 
    210                 215                 220                 


Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp 
225                 230                 235                 240 


Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
                245                 250     


<210>  7
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    210                 215                 


<210>  8
<211>  268
<212>  PRT
<213>  Mus musculus

<400>  8

Met Glu Pro Arg Leu Leu Met Leu Gly Phe Leu Ser Leu Thr Ile Val 
1               5                   10                  15      


Pro Ser Cys Arg Ala Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro 
            20                  25                  30          


Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met 
    50                  55                  60                  


Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn 
65                  70                  75                  80  


Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln 
                85                  90                  95      


Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met 
            100                 105                 110         


His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys 
        115                 120                 125             


His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val 
    130                 135                 140                 


His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala 
145                 150                 155                 160 


Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro 
                165                 170                 175     


Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg Phe Leu Ala Ser 
            180                 185                 190         


Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser 
        195                 200                 205             


Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala 
    210                 215                 220                 


Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys Val Ala Val Ala 
225                 230                 235                 240 


Ser Cys Leu Phe Leu Leu Ile Ser Ile Leu Leu Leu Ser Gly Leu Thr 
                245                 250                 255     


Trp Gln His Arg Trp Arg Lys Ser Arg Arg Thr Ile 
            260                 265             


<210>  9
<211>  247
<212>  PRT
<213>  Mus musculus

<400>  9

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr Phe Lys 
1               5                   10                  15      


Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu Gly Asn 
        35                  40                  45              


Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp Lys Ser 
    50                  55                  60                  


Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln Gln Thr 
65                  70                  75                  80  


Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met His Gln Glu Asn Leu 
                85                  90                  95      


Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp Ser Lys 
            100                 105                 110         


Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val His Tyr Glu Cys Ile 
        115                 120                 125             


Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile Cys Lys 
    130                 135                 140                 


Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr Cys Val 
145                 150                 155                 160 


Asp Glu Arg Glu His His Arg Phe Leu Ala Ser Glu Glu Ser Gln Gly 
                165                 170                 175     


Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile Thr Thr 
            180                 185                 190         


Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu Thr Phe 
        195                 200                 205             


Val Leu Thr Met Glu Tyr Lys Val Ala Val Ala Ser Cys Leu Phe Leu 
    210                 215                 220                 


Leu Ile Ser Ile Leu Leu Leu Ser Gly Leu Thr Trp Gln His Arg Trp 
225                 230                 235                 240 


Arg Lys Ser Arg Arg Thr Ile 
                245         


<210>  10
<211>  215
<212>  PRT
<213>  Mus musculus

<400>  10

Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr Phe Lys 
1               5                   10                  15      


Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu Gly Asn 
        35                  40                  45              


Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp Lys Ser 
    50                  55                  60                  


Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln Gln Thr 
65                  70                  75                  80  


Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met His Gln Glu Asn Leu 
                85                  90                  95      


Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp Ser Lys 
            100                 105                 110         


Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val His Tyr Glu Cys Ile 
        115                 120                 125             


Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile Cys Lys 
    130                 135                 140                 


Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr Cys Val 
145                 150                 155                 160 


Asp Glu Arg Glu His His Arg Phe Leu Ala Ser Glu Glu Ser Gln Gly 
                165                 170                 175     


Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile Thr Thr 
            180                 185                 190         


Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu Thr Phe 
        195                 200                 205             


Val Leu Thr Met Glu Tyr Lys 
    210                 215 


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly3Ser)4 linker

<400>  11

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly3Ser)2 linker

<400>  12

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly3Ser)3 linker

<400>  13

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly3Ser)5 linker

<400>  14

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gly3Ser linker

<400>  15

Gly Gly Gly Ser 
1               


<210>  16
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized Mature form of IL-2 (Gly4Ser)4-extracellular domain 
       of IL-2 R

<400>  16

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
        35                  40                  45              


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
    50                  55                  60                  


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
65                  70                  75                  80  


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Cys Leu Tyr Asp Pro 
                165                 170                 175     


Pro Glu Val Pro Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly 
            180                 185                 190         


Thr Ile Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu 
        195                 200                 205             


Leu Val Tyr Met Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln 
    210                 215                 220                 


Cys Thr Ser Asn Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln 
225                 230                 235                 240 


Leu Glu His Gln Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro 
                245                 250                 255     


Thr Gln Ser Met His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro 
            260                 265                 270         


Pro Pro Trp Lys His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu 
        275                 280                 285             


Gly Gln Ser Val His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln 
    290                 295                 300                 


Arg Gly Pro Ala Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly 
305                 310                 315                 320 


Trp Thr Gln Pro Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg 
                325                 330                 335     


Phe Leu Ala Ser Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu 
            340                 345                 350         


Ser Glu Thr Ser Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr 
        355                 360                 365             


Glu Thr Thr Ala Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys 
    370                 375                 380                 


<210>  17
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form of IL-2 (Gly4Ser)4-extracellular 
       domain of IL-2 R

<400>  17

Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Cys 
            180                 185                 190         


Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr Phe Lys Ala Leu Ser 
        195                 200                 205             


Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg 
    210                 215                 220                 


Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu Gly Asn Ser Trp Ser 
225                 230                 235                 240 


Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp Lys Ser Arg Lys Gln 
                245                 250                 255     


Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln Gln Thr Thr Thr Asp 
            260                 265                 270         


Met Gln Lys Pro Thr Gln Ser Met His Gln Glu Asn Leu Thr Gly His 
        275                 280                 285             


Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp Ser Lys Arg Ile Tyr 
    290                 295                 300                 


His Phe Val Glu Gly Gln Ser Val His Tyr Glu Cys Ile Pro Gly Tyr 
305                 310                 315                 320 


Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile Cys Lys Met Lys Cys 
                325                 330                 335     


Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr Cys Val Asp Glu Arg 
            340                 345                 350         


Glu His His Arg Phe Leu Ala Ser Glu Glu Ser Gln Gly Ser Arg Asn 
        355                 360                 365             


Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile Thr Thr Thr Asp Phe 
    370                 375                 380                 


Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu Thr Phe Val Leu Thr 
385                 390                 395                 400 


Met Glu Tyr Lys 
                


<210>  18
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized mature form of IL-2 (Gly4Ser)5- extracellular domain 
       of IL-2 R

<400>  18

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
        35                  40                  45              


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
    50                  55                  60                  


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
65                  70                  75                  80  


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu 
                165                 170                 175     


Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr Phe Lys Ala Leu 
            180                 185                 190         


Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg Gly Phe 
        195                 200                 205             


Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu Gly Asn Ser Trp 
    210                 215                 220                 


Ser Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp Lys Ser Arg Lys 
225                 230                 235                 240 


Gln Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln Gln Thr Thr Thr 
                245                 250                 255     


Asp Met Gln Lys Pro Thr Gln Ser Met His Gln Glu Asn Leu Thr Gly 
            260                 265                 270         


His Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp Ser Lys Arg Ile 
        275                 280                 285             


Tyr His Phe Val Glu Gly Gln Ser Val His Tyr Glu Cys Ile Pro Gly 
    290                 295                 300                 


Tyr Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile Cys Lys Met Lys 
305                 310                 315                 320 


Cys Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr Cys Val Asp Glu 
                325                 330                 335     


Arg Glu His His Arg Phe Leu Ala Ser Glu Glu Ser Gln Gly Ser Arg 
            340                 345                 350         


Asn Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile Thr Thr Thr Asp 
        355                 360                 365             


Phe Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu Thr Phe Val Leu 
    370                 375                 380                 


Thr Met Glu Tyr Lys 
385                 


<210>  19
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form of IL-2 (Gly4Ser)5- extracellular 
       domain of IL-2 R

<400>  19

Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Ser Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr 
        195                 200                 205             


Phe Lys Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys 
    210                 215                 220                 


Lys Arg Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu 
225                 230                 235                 240 


Gly Asn Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp 
                245                 250                 255     


Lys Ser Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln 
            260                 265                 270         


Gln Thr Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met His Gln Glu 
        275                 280                 285             


Asn Leu Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp 
    290                 295                 300                 


Ser Lys Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val His Tyr Glu 
305                 310                 315                 320 


Cys Ile Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile 
                325                 330                 335     


Cys Lys Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr 
            340                 345                 350         


Cys Val Asp Glu Arg Glu His His Arg Phe Leu Ala Ser Glu Glu Ser 
        355                 360                 365             


Gln Gly Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile 
    370                 375                 380                 


Thr Thr Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu 
385                 390                 395                 400 


Thr Phe Val Leu Thr Met Glu Tyr Lys 
                405                 


<210>  20
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized mature form of IL-2 (Gly3Ser)4- extracellular domain 
       of IL-2 R

<400>  20

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
        35                  40                  45              


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
    50                  55                  60                  


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
65                  70                  75                  80  


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Ser Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro 
                165                 170                 175     


Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn 
            180                 185                 190         


Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met 
        195                 200                 205             


Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn 
    210                 215                 220                 


Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln 
225                 230                 235                 240 


Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met 
                245                 250                 255     


His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys 
            260                 265                 270         


His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val 
        275                 280                 285             


His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala 
    290                 295                 300                 


Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro 
305                 310                 315                 320 


Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg Phe Leu Ala Ser 
                325                 330                 335     


Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser 
            340                 345                 350         


Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala 
        355                 360                 365             


Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys 
    370                 375                 380 


<210>  21
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form of IL-2 (Gly3Ser)4- extracellular 
       domain of IL-2 R

<400>  21

Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Leu Cys Leu Tyr Asp Pro 
            180                 185                 190         


Pro Glu Val Pro Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly 
        195                 200                 205             


Thr Ile Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu 
    210                 215                 220                 


Leu Val Tyr Met Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln 
225                 230                 235                 240 


Cys Thr Ser Asn Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln 
                245                 250                 255     


Leu Glu His Gln Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro 
            260                 265                 270         


Thr Gln Ser Met His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro 
        275                 280                 285             


Pro Pro Trp Lys His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu 
    290                 295                 300                 


Gly Gln Ser Val His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln 
305                 310                 315                 320 


Arg Gly Pro Ala Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly 
                325                 330                 335     


Trp Thr Gln Pro Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg 
            340                 345                 350         


Phe Leu Ala Ser Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu 
        355                 360                 365             


Ser Glu Thr Ser Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr 
    370                 375                 380                 


Glu Thr Thr Ala Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys 
385                 390                 395                 400 


<210>  22
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized mature form IL-2 (Gly4Ser)4- extracellular domain of 
       IL-2 R

<400>  22

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro 
145                 150                 155                 160 


Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly 
                165                 170                 175     


Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser 
            180                 185                 190         


Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp 
        195                 200                 205             


Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys 
    210                 215                 220                 


Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu 
225                 230                 235                 240 


Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His 
                245                 250                 255     


Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr 
            260                 265                 270         


His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr 
        275                 280                 285             


Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His 
    290                 295                 300                 


Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met 
305                 310                 315                 320 


Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu 
                325                 330                 335     


Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe 
            340                 345                 350         


Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr 
        355                 360                 365             


Thr Glu Tyr Gln 
    370         


<210>  23
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form IL-2 (Gly4Ser)4- extracellular 
       domain of IL-2 R

<400>  23

Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Cys 
                165                 170                 175     


Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala 
            180                 185                 190         


Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg 
        195                 200                 205             


Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser 
    210                 215                 220                 


His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg 
225                 230                 235                 240 


Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg 
                245                 250                 255     


Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser 
            260                 265                 270         


Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr 
        275                 280                 285             


Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys 
    290                 295                 300                 


Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys 
305                 310                 315                 320 


Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys 
                325                 330                 335     


Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln 
            340                 345                 350         


Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr 
        355                 360                 365             


Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr 
    370                 375                 380                 


Ser Ile Phe Thr Thr Glu Tyr Gln 
385                 390         


<210>  24
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized mature form IL-2 (Gly3Ser)4- extracellular domain of 
       IL-2 R

<400>  24

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
145                 150                 155                 160 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
                165                 170                 175     


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
            180                 185                 190         


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
        195                 200                 205             


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
    210                 215                 220                 


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
225                 230                 235                 240 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
                245                 250                 255     


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
            260                 265                 270         


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
        275                 280                 285             


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
    290                 295                 300                 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
305                 310                 315                 320 


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
                325                 330                 335     


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
            340                 345                 350         


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
        355                 360                 365             


<210>  25
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form IL-2 (Gly3Ser)4- extracellular 
       domain of IL-2 R

<400>  25

Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro 
                165                 170                 175     


Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly 
            180                 185                 190         


Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser 
        195                 200                 205             


Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp 
    210                 215                 220                 


Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys 
225                 230                 235                 240 


Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu 
                245                 250                 255     


Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His 
            260                 265                 270         


Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr 
        275                 280                 285             


His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr 
    290                 295                 300                 


Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His 
305                 310                 315                 320 


Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met 
                325                 330                 335     


Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu 
            340                 345                 350         


Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe 
        355                 360                 365             


Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr 
    370                 375                 380                 


Thr Glu Tyr Gln 
385             


<210>  26
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized mature form IL-2 (Gly3Ser)3- extracellular domain of 
       IL-2 R

<400>  26

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe 
145                 150                 155                 160 


Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys 
                165                 170                 175     


Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr 
            180                 185                 190         


Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser 
        195                 200                 205             


Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu 
    210                 215                 220                 


Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val 
225                 230                 235                 240 


Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu 
                245                 250                 255     


Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val 
            260                 265                 270         


Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala 
        275                 280                 285             


Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro 
    290                 295                 300                 


Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu 
305                 310                 315                 320 


Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser 
                325                 330                 335     


Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala 
            340                 345                 350         


Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
        355                 360                 


<210>  27
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form of IL-2 (Gly3Ser)3- extracellular 
       domain of IL-2 R

<400>  27

Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
                165                 170                 175     


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
            180                 185                 190         


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
        195                 200                 205             


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
    210                 215                 220                 


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
225                 230                 235                 240 


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
                245                 250                 255     


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
            260                 265                 270         


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
        275                 280                 285             


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
    290                 295                 300                 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
305                 310                 315                 320 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
                325                 330                 335     


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
            340                 345                 350         


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
        355                 360                 365             


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    370                 375                 380                 


<210>  28
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2 leader optimized Kozak sequence

<400>  28
gccaccatgg acaggatgca actcctgtct tgcattgcac taagtcttgc acttgtcaca       60

aacagt                                                                  66


<210>  29
<211>  1239
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form of IL-2 (Gly4Ser)4-extracellular 
       domain of IL-2 R

<400>  29
atggacagca tgcagctcgc atcctgtgtc acattgacac ttgtgctcct tgtcaacagc       60

gcacccactt caagctctac ttcaagctct acagcggaag cacagcagca gcagcagcag      120

cagcagcagc agcagcacct ggagcagctg ttgatggacc tacaggagct cctgagcagg      180

atggagaatt acaggaacct gaaactcccc aggatgctca ccttcaaatt ttacttgccc      240

aagcaggcca cagaattgaa agatcttcag tgcctagaag atgaacttgg acctctgcgg      300

catgttctgg atttgactca aagcaaaagc tttcaattgg aagatgctga gaatttcatc      360

agcaatatca gagtaactgt tgtaaaacta aagggctctg acaacacatt tgagtgccaa      420

ttcgatgatg agtcagcaac tgtggtggac tttctgagga gatggatagc cttctgtcaa      480

agcatcatct caacaagccc tcaaggtgga ggtggatctg gtggaggtgg atcaggtgga      540

ggtggatccg gtggaggtgg atctgaactg tgtctgtatg acccacccga ggtccccaat      600

gccacattca aagccctctc ctacaagaac ggcaccatcc taaactgtga atgcaagaga      660

ggtttccgaa gactaaagga attggtctat atgcgttgct taggaaactc ctggagcagc      720

aactgccagt gcaccagcaa ctcccatgac aaatcgagaa agcaagttac agctcaactt      780

gaacaccaga aagagcaaca aaccacaaca gacatgcaga agccaacaca gtctatgcac      840

caagagaacc ttacaggtca ctgcagggag ccacctcctt ggaaacatga agattccaag      900

agaatctatc atttcgtgga aggacagagt gttcactacg agtgtattcc gggatacaag      960

gctctacaga gaggtcctgc tattagcatc tgcaagatga agtgtgggaa aacggggtgg     1020

actcagcccc agctcacatg tgtagatgaa agagaacacc accgatttct ggctagtgag     1080

gaatctcaag gaagcagaaa ttcttctccc gagagtgaga cttcctgccc cataaccacc     1140

acagacttcc cacaacccac agaaacaact gcaatgacgg agacatttgt gctcacaatg     1200

gagtataagg gtggacatca ccatcaccat cactaataa                            1239


<210>  30
<211>  1227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form of IL-2 (Gly3Ser)4- extracellular 
       domain of IL-2 R

<400>  30
atggacagca tgcagctcgc atcctgtgtc acattgacac ttgtgctcct tgtcaacagc       60

gcacccactt caagctctac ttcaagctct acagcggaag cacagcagca gcagcagcag      120

cagcagcagc agcagcacct ggagcagctg ttgatggacc tacaggagct cctgagcagg      180

atggagaatt acaggaacct gaaactcccc aggatgctca ccttcaaatt ttacttgccc      240

aagcaggcca cagaattgaa agatcttcag tgcctagaag atgaacttgg acctctgcgg      300

catgttctgg atttgactca aagcaaaagc tttcaattgg aagatgctga gaatttcatc      360

agcaatatca gagtaactgt tgtaaaacta aagggctctg acaacacatt tgagtgccaa      420

ttcgatgatg agtcagcaac tgtggtggac tttctgagga gatggatagc cttctgtcaa      480

agcatcatct caacaagccc tcaaggtgga ggttctggtg gaggttcagg tggaggttcg      540

ggtggaggtt ctgaactgtg tctgtatgac ccacccgagg tccccaatgc cacattcaaa      600

gccctctcct acaagaacgg caccatccta aactgtgaat gcaagagagg tttccgaaga      660

ctaaaggaat tggtctatat gcgttgctta ggaaactcct ggagcagcaa ctgccagtgc      720

accagcaact cccatgacaa atcgagaaag caagttacag ctcaacttga acaccagaaa      780

gagcaacaaa ccacaacaga catgcagaag ccaacacagt ctatgcacca agagaacctt      840

acaggtcact gcagggagcc acctccttgg aaacatgaag attccaagag aatctatcat      900

ttcgtggaag gacagagtgt tcactacgag tgtattccgg gatacaaggc tctacagaga      960

ggtcctgcta ttagcatctg caagatgaag tgtgggaaaa cggggtggac tcagccccag     1020

ctcacatgtg tagatgaaag agaacaccac cgatttctgg ctagtgagga atctcaagga     1080

agcagaaatt cttctcccga gagtgagact tcctgcccca taaccaccac agacttccca     1140

caacccacag aaacaactgc aatgacggag acatttgtgc tcacaatgga gtataagggt     1200

ggacatcacc atcaccatca ctaataa                                         1227


<210>  31
<211>  1254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form of IL-2 (Gly4Ser)5- extracellular 
       domain of IL-2 R

<400>  31
atggacagca tgcagctcgc atcctgtgtc acattgacac ttgtgctcct tgtcaacagc       60

gcacccactt caagctctac ttcaagctct acagcggaag cacagcagca gcagcagcag      120

cagcagcagc agcagcacct ggagcagctg ttgatggacc tacaggagct cctgagcagg      180

atggagaatt acaggaacct gaaactcccc aggatgctca ccttcaaatt ttacttgccc      240

aagcaggcca cagaattgaa agatcttcag tgcctagaag atgaacttgg acctctgcgg      300

catgttctgg atttgactca aagcaaaagc tttcaattgg aagatgctga gaatttcatc      360

agcaatatca gagtaactgt tgtaaaacta aagggctctg acaacacatt tgagtgccaa      420

ttcgatgatg agtcagcaac tgtggtggac tttctgagga gatggatagc cttctgtcaa      480

agcatcatct caacaagccc tcaaggtgga ggtggatcag gtggaggtgg atctggtgga      540

ggtggatcag gtggaggtgg atccggtgga ggtggatctg aactgtgtct gtatgaccca      600

cccgaggtcc ccaatgccac attcaaagcc ctctcctaca agaacggcac catcctaaac      660

tgtgaatgca agagaggttt ccgaagacta aaggaattgg tctatatgcg ttgcttagga      720

aactcctgga gcagcaactg ccagtgcacc agcaactccc atgacaaatc gagaaagcaa      780

gttacagctc aacttgaaca ccagaaagag caacaaacca caacagacat gcagaagcca      840

acacagtcta tgcaccaaga gaaccttaca ggtcactgca gggagccacc tccttggaaa      900

catgaagatt ccaagagaat ctatcatttc gtggaaggac agagtgttca ctacgagtgt      960

attccgggat acaaggctct acagagaggt cctgctatta gcatctgcaa gatgaagtgt     1020

gggaaaacgg ggtggactca gccccagctc acatgtgtag atgaaagaga acaccaccga     1080

tttctggcta gtgaggaatc tcaaggaagc agaaattctt ctcccgagag tgagacttcc     1140

tgccccataa ccaccacaga cttcccacaa cccacagaaa caactgcaat gacggagaca     1200

tttgtgctca caatggagta taagggtgga catcaccatc accatcacta ataa           1254


<210>  32
<211>  1206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form IL-2 (Gly4Ser)4- extracellular 
       domain of IL-2 R

<400>  32
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactg gtggaggtgg atctggtgga      480

ggtggatcag gtggaggtgg atccggtgga ggtggatctg agctctgtga cgatgacccg      540

ccagagatcc cacacgccac attcaaagcc atggcctaca aggaaggaac catgttgaac      600

tgtgaatgca agagaggttt ccgcagaata aaaagcgggt cactctatat gctctgtaca      660

ggaaactcta gccactcgtc ctgggacaac caatgtcaat gcacaagctc tgccactcgg      720

aacacaacga aacaagtgac acctcaacct gaagaacaga aagaaaggaa aaccacagaa      780

atgcaaagtc caatgcagcc agtggaccaa gcgagccttc caggtcactg cagggaacct      840

ccaccatggg aaaatgaagc cacagagaga atttatcatt tcgtggtggg gcagatggtt      900

tattatcagt gcgtccaggg atacagggct ctacacagag gtcctgctga gagcgtctgc      960

aaaatgaccc acgggaagac aaggtggacc cagccccagc tcatatgcac aggtgaaatg     1020

gagaccagtc agtttccagg tgaagagaag cctcaggcaa gccccgaagg ccgtcctgag     1080

agtgagactt cctgcctcgt cacaacaaca gattttcaaa tacagacaga aatggctgca     1140

accatggaga cgtccatatt tacaacagag taccagggtg gacatcacca tcaccatcac     1200

taataa                                                                1206


<210>  33
<211>  1194
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form IL-2 (Gly3Ser)4- extracellular 
       domain of IL-2 R

<400>  33
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactg gtggaggttc tggtggaggt      480

tcaggtggag gttcgggtgg aggttctgag ctctgtgacg atgacccgcc agagatccca      540

cacgccacat tcaaagccat ggcctacaag gaaggaacca tgttgaactg tgaatgcaag      600

agaggtttcc gcagaataaa aagcgggtca ctctatatgc tctgtacagg aaactctagc      660

cactcgtcct gggacaacca atgtcaatgc acaagctctg ccactcggaa cacaacgaaa      720

caagtgacac ctcaacctga agaacagaaa gaaaggaaaa ccacagaaat gcaaagtcca      780

atgcagccag tggaccaagc gagccttcca ggtcactgca gggaacctcc accatgggaa      840

aatgaagcca cagagagaat ttatcatttc gtggtggggc agatggttta ttatcagtgc      900

gtccagggat acagggctct acacagaggt cctgctgaga gcgtctgcaa aatgacccac      960

gggaagacaa ggtggaccca gccccagctc atatgcacag gtgaaatgga gaccagtcag     1020

tttccaggtg aagagaagcc tcaggcaagc cccgaaggcc gtcctgagag tgagacttcc     1080

tgcctcgtca caacaacaga ttttcaaata cagacagaaa tggctgcaac catggagacg     1140

tccatattta caacagagta ccagggtgga catcaccatc accatcacta ataa           1194


<210>  34
<211>  1182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form of IL-2 (Gly3Ser)3- extracellular 
       domain of IL-2 R

<400>  34
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactg gtggaggttc tggtggaggt      480

tcaggtggag gttcggagct ctgtgacgat gacccgccag agatcccaca cgccacattc      540

aaagccatgg cctacaagga aggaaccatg ttgaactgtg aatgcaagag aggtttccgc      600

agaataaaaa gcgggtcact ctatatgctc tgtacaggaa actctagcca ctcgtcctgg      660

gacaaccaat gtcaatgcac aagctctgcc actcggaaca caacgaaaca agtgacacct      720

caacctgaag aacagaaaga aaggaaaacc acagaaatgc aaagtccaat gcagccagtg      780

gaccaagcga gccttccagg tcactgcagg gaacctccac catgggaaaa tgaagccaca      840

gagagaattt atcatttcgt ggtggggcag atggtttatt atcagtgcgt ccagggatac      900

agggctctac acagaggtcc tgctgagagc gtctgcaaaa tgacccacgg gaagacaagg      960

tggacccagc cccagctcat atgcacaggt gaaatggaga ccagtcagtt tccaggtgaa     1020

gagaagcctc aggcaagccc cgaaggccgt cctgagagtg agacttcctg cctcgtcaca     1080

acaacagatt ttcaaataca gacagaaatg gctgcaacca tggagacgtc catatttaca     1140

acagagtacc agggtggaca tcaccatcac catcactaat aa                        1182


<210>  35
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak consensus

<400>  35
gccgccrcca ugg                                                          13


<210>  36
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form of IL-2 (Gly3Ser)3- extracellular 
       domain of IL-2 R

<400>  36

Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Gly Ser Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro 
            180                 185                 190         


Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn 
        195                 200                 205             


Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met 
    210                 215                 220                 


Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn 
225                 230                 235                 240 


Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln 
                245                 250                 255     


Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met 
            260                 265                 270         


His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys 
        275                 280                 285             


His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val 
    290                 295                 300                 


His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala 
305                 310                 315                 320 


Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro 
                325                 330                 335     


Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg Phe Leu Ala Ser 
            340                 345                 350         


Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser 
        355                 360                 365             


Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala 
    370                 375                 380                 


Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys 
385                 390                 395     


<210>  37
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized mature form of IL-2 (Gly3Ser)3- extracellular domain 
       of IL-2 R

<400>  37

Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Gly Ser Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro 
            180                 185                 190         


Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn 
        195                 200                 205             


Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met 
    210                 215                 220                 


Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn 
225                 230                 235                 240 


Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln 
                245                 250                 255     


Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met 
            260                 265                 270         


His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys 
        275                 280                 285             


His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val 
    290                 295                 300                 


His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala 
305                 310                 315                 320 


Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro 
                325                 330                 335     


Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg Phe Leu Ala Ser 
            340                 345                 350         


Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser 
        355                 360                 365             


Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala 
    370                 375                 380                 


Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys 
385                 390                 395     


<210>  38
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form of IL-2 (Gly4Ser)5- extracellular 
       domain of IL-2 R

<400>  38

Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr 
            180                 185                 190         


Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys 
        195                 200                 205             


Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys 
    210                 215                 220                 


Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr 
225                 230                 235                 240 


Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu 
                245                 250                 255     


Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro 
            260                 265                 270         


Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp 
        275                 280                 285             


Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met 
    290                 295                 300                 


Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro 
305                 310                 315                 320 


Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln 
                325                 330                 335     


Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly 
            340                 345                 350         


Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr 
        355                 360                 365             


Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala 
    370                 375                 380                 


Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
385                 390                 395         


<210>  39
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized mature form of human IL-2 (Gly4Ser)5- extracellular 
       domain of IL-2 R

<400>  39

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu 
145                 150                 155                 160 


Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met 
                165                 170                 175     


Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe 
            180                 185                 190         


Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser 
        195                 200                 205             


Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr 
    210                 215                 220                 


Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu 
225                 230                 235                 240 


Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala 
                245                 250                 255     


Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala 
            260                 265                 270         


Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln 
        275                 280                 285             


Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val 
    290                 295                 300                 


Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile 
305                 310                 315                 320 


Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro 
                325                 330                 335     


Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val 
            340                 345                 350         


Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu 
        355                 360                 365             


Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    370                 375         


<210>  40
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence (Gly4Ser)4

<400>  40

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  41
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence (Gly4Ser)5

<400>  41

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  42
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form IL-2 (Gly3Ser)3- extracellular 
       domain of IL-2 R

<400>  42
atggacagca tgcagctcgc atcctgtgtc acattgacac ttgtgctcct tgtcaacagc       60

gcacccactt caagctctac ttcaagctct acagcggaag cacagcagca gcagcagcag      120

cagcagcagc agcagcacct ggagcagctg ttgatggacc tacaggagct cctgagcagg      180

atggagaatt acaggaacct gaaactcccc aggatgctca ccttcaaatt ttacttgccc      240

aagcaggcca cagaattgaa agatcttcag tgcctagaag atgaacttgg acctctgcgg      300

catgttctgg atttgactca aagcaaaagc tttcaattgg aagatgctga gaatttcatc      360

agcaatatca gagtaactgt tgtaaaacta aagggctctg acaacacatt tgagtgccaa      420

ttcgatgatg agtcagcaac tgtggtggac tttctgagga gatggatagc cttctgtcaa      480

agcatcatct caacaagccc tcaaggtgga ggttctggtg gaggttcagg tggaggttcg      540

gaactgtgtc tgtatgaccc acccgaggtc cccaatgcca cattcaaagc cctctcctac      600

aagaacggca ccatcctaaa ctgtgaatgc aagagaggtt tccgaagact aaaggaattg      660

gtctatatgc gttgcttagg aaactcctgg agcagcaact gccagtgcac cagcaactcc      720

catgacaaat cgagaaagca agttacagct caacttgaac accagaaaga gcaacaaacc      780

acaacagaca tgcagaagcc aacacagtct atgcaccaag agaaccttac aggtcactgc      840

agggagccac ctccttggaa acatgaagat tccaagagaa tctatcattt cgtggaagga      900

cagagtgttc actacgagtg tattccggga tacaaggctc tacagagagg tcctgctatt      960

agcatctgca agatgaagtg tgggaaaacg gggtggactc agccccagct cacatgtgta     1020

gatgaaagag aacaccaccg atttctggct agtgaggaat ctcaaggaag cagaaattct     1080

tctcccgaga gtgagacttc ctgccccata accaccacag acttcccaca acccacagaa     1140

acaactgcaa tgacggagac atttgtgctc acaatggagt ataagggtgg acatcaccat     1200

caccatcact aataa                                                      1215


<210>  43
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized mature form IL-2 (Gly3Ser)2- extracellular domain of 
       IL-2 R

<400>  43

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly Ser Glu Leu Cys 
    130                 135                 140                 


Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala 
145                 150                 155                 160 


Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg 
                165                 170                 175     


Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser 
            180                 185                 190         


His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg 
        195                 200                 205             


Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg 
    210                 215                 220                 


Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser 
225                 230                 235                 240 


Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr 
                245                 250                 255     


Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys 
            260                 265                 270         


Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys 
        275                 280                 285             


Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys 
    290                 295                 300                 


Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln 
305                 310                 315                 320 


Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr 
                325                 330                 335     


Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr 
            340                 345                 350         


Ser Ile Phe Thr Thr Glu Tyr Gln 
        355                 360 


<210>  44
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form IL-2 (Gly3Ser)2- extracellular 
       domain of IL-2 R

<400>  44

Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe 
                165                 170                 175     


Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys 
            180                 185                 190         


Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr 
        195                 200                 205             


Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser 
    210                 215                 220                 


Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu 
225                 230                 235                 240 


Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val 
                245                 250                 255     


Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu 
            260                 265                 270         


Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val 
        275                 280                 285             


Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala 
    290                 295                 300                 


Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro 
305                 310                 315                 320 


Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu 
                325                 330                 335     


Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser 
            340                 345                 350         


Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala 
        355                 360                 365             


Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    370                 375                 380 


<210>  45
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized mature form IL-2 (Gly3)- extracellular domain of IL-2
       R

<400>  45

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Glu Leu Cys Asp Asp Asp Pro Pro 
    130                 135                 140                 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
145                 150                 155                 160 


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
                165                 170                 175     


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
            180                 185                 190         


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
        195                 200                 205             


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
    210                 215                 220                 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
225                 230                 235                 240 


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
                245                 250                 255     


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
            260                 265                 270         


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
        275                 280                 285             


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu 
    290                 295                 300                 


Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly 
305                 310                 315                 320 


Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln 
                325                 330                 335     


Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr 
            340                 345                 350         


Glu Tyr Gln 
        355 


<210>  46
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form IL-2 (Gly3)- extracellular domain of
       IL-2 R

<400>  46

Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Glu Leu Cys Asp 
145                 150                 155                 160 


Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr 
                165                 170                 175     


Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg 
            180                 185                 190         


Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His 
        195                 200                 205             


Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn 
    210                 215                 220                 


Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys 
225                 230                 235                 240 


Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu 
                245                 250                 255     


Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu 
            260                 265                 270         


Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val 
        275                 280                 285             


Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys 
    290                 295                 300                 


Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr 
305                 310                 315                 320 


Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln Ala 
                325                 330                 335     


Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr Thr 
            340                 345                 350         


Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr Ser 
        355                 360                 365             


Ile Phe Thr Thr Glu Tyr Gln 
    370                 375 


<210>  47
<211>  1170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form IL-2 (Gly3Ser)2- extracellular 
       domain of IL-2 R

<400>  47
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactg gtggaggttc tggtggaggt      480

tcagagctct gtgacgatga cccgccagag atcccacacg ccacattcaa agccatggcc      540

tacaaggaag gaaccatgtt gaactgtgaa tgcaagagag gtttccgcag aataaaaagc      600

gggtcactct atatgctctg tacaggaaac tctagccact cgtcctggga caaccaatgt      660

caatgcacaa gctctgccac tcggaacaca acgaaacaag tgacacctca acctgaagaa      720

cagaaagaaa ggaaaaccac agaaatgcaa agtccaatgc agccagtgga ccaagcgagc      780

cttccaggtc actgcaggga acctccacca tgggaaaatg aagccacaga gagaatttat      840

catttcgtgg tggggcagat ggtttattat cagtgcgtcc agggatacag ggctctacac      900

agaggtcctg ctgagagcgt ctgcaaaatg acccacggga agacaaggtg gacccagccc      960

cagctcatat gcacaggtga aatggagacc agtcagtttc caggtgaaga gaagcctcag     1020

gcaagccccg aaggccgtcc tgagagtgag acttcctgcc tcgtcacaac aacagatttt     1080

caaatacaga cagaaatggc tgcaaccatg gagacgtcca tatttacaac agagtaccag     1140

ggtggacatc accatcacca tcactaataa                                      1170


<210>  48
<211>  1155
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form IL-2 (Gly3)- extracellular domain of
       IL-2 R

<400>  48
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactg gtggaggtga gctctgtgac      480

gatgacccgc cagagatccc acacgccaca ttcaaagcca tggcctacaa ggaaggaacc      540

atgttgaact gtgaatgcaa gagaggtttc cgcagaataa aaagcgggtc actctatatg      600

ctctgtacag gaaactctag ccactcgtcc tgggacaacc aatgtcaatg cacaagctct      660

gccactcgga acacaacgaa acaagtgaca cctcaacctg aagaacagaa agaaaggaaa      720

accacagaaa tgcaaagtcc aatgcagcca gtggaccaag cgagccttcc aggtcactgc      780

agggaacctc caccatggga aaatgaagcc acagagagaa tttatcattt cgtggtgggg      840

cagatggttt attatcagtg cgtccaggga tacagggctc tacacagagg tcctgctgag      900

agcgtctgca aaatgaccca cgggaagaca aggtggaccc agccccagct catatgcaca      960

ggtgaaatgg agaccagtca gtttccaggt gaagagaagc ctcaggcaag ccccgaaggc     1020

cgtcctgaga gtgagacttc ctgcctcgtc acaacaacag attttcaaat acagacagaa     1080

atggctgcaa ccatggagac gtccatattt acaacagagt accagggtgg acatcaccat     1140

caccatcact aataa                                                      1155


<210>  49
<211>  1221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form IL-2 (Gly4Ser)5- extracellular 
       domain of IL-2 R

<400>  49
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactg gtggaggtgg atcaggtgga      480

ggtggatctg gtggaggtgg atcaggtgga ggtggatccg gtggaggtgg atctgagctc      540

tgtgacgatg acccgccaga gatcccacac gccacattca aagccatggc ctacaaggaa      600

ggaaccatgt tgaactgtga atgcaagaga ggtttccgca gaataaaaag cgggtcactc      660

tatatgctct gtacaggaaa ctctagccac tcgtcctggg acaaccaatg tcaatgcaca      720

agctctgcca ctcggaacac aacgaaacaa gtgacacctc aacctgaaga acagaaagaa      780

aggaaaacca cagaaatgca aagtccaatg cagccagtgg accaagcgag ccttccaggt      840

cactgcaggg aacctccacc atgggaaaat gaagccacag agagaattta tcatttcgtg      900

gtggggcaga tggtttatta tcagtgcgtc cagggataca gggctctaca cagaggtcct      960

gctgagagcg tctgcaaaat gacccacggg aagacaaggt ggacccagcc ccagctcata     1020

tgcacaggtg aaatggagac cagtcagttt ccaggtgaag agaagcctca ggcaagcccc     1080

gaaggccgtc ctgagagtga gacttcctgc ctcgtcacaa caacagattt tcaaatacag     1140

acagaaatgg ctgcaaccat ggagacgtcc atatttacaa cagagtacca gggtggacat     1200

caccatcacc atcactaata a                                               1221


<210>  50
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)3 linker

<400>  50

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)2 linker

<400>  51

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)1 linker

<400>  52

Gly Gly Gly Gly Ser 
1               5   


<210>  53
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak sequence

<400>  53
gccaccatgg                                                              10


<210>  54
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form of IL-2 (Gly4Ser)4-extracellular 
       domain of IL-2 R + glycine spacer and poly-histidine region

<400>  54

Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Cys 
            180                 185                 190         


Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr Phe Lys Ala Leu Ser 
        195                 200                 205             


Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg 
    210                 215                 220                 


Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu Gly Asn Ser Trp Ser 
225                 230                 235                 240 


Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp Lys Ser Arg Lys Gln 
                245                 250                 255     


Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln Gln Thr Thr Thr Asp 
            260                 265                 270         


Met Gln Lys Pro Thr Gln Ser Met His Gln Glu Asn Leu Thr Gly His 
        275                 280                 285             


Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp Ser Lys Arg Ile Tyr 
    290                 295                 300                 


His Phe Val Glu Gly Gln Ser Val His Tyr Glu Cys Ile Pro Gly Tyr 
305                 310                 315                 320 


Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile Cys Lys Met Lys Cys 
                325                 330                 335     


Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr Cys Val Asp Glu Arg 
            340                 345                 350         


Glu His His Arg Phe Leu Ala Ser Glu Glu Ser Gln Gly Ser Arg Asn 
        355                 360                 365             


Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile Thr Thr Thr Asp Phe 
    370                 375                 380                 


Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu Thr Phe Val Leu Thr 
385                 390                 395                 400 


Met Glu Tyr Lys Gly Gly His His His His His His 
                405                 410         


<210>  55
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form of IL-2 (Gly4Ser)5- extracellular 
       domain of IL-2 R + glycine spacer and poly-histidine region

<400>  55

Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Ser Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro Asn Ala Thr 
        195                 200                 205             


Phe Lys Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn Cys Glu Cys 
    210                 215                 220                 


Lys Arg Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met Arg Cys Leu 
225                 230                 235                 240 


Gly Asn Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn Ser His Asp 
                245                 250                 255     


Lys Ser Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln Lys Glu Gln 
            260                 265                 270         


Gln Thr Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met His Gln Glu 
        275                 280                 285             


Asn Leu Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys His Glu Asp 
    290                 295                 300                 


Ser Lys Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val His Tyr Glu 
305                 310                 315                 320 


Cys Ile Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala Ile Ser Ile 
                325                 330                 335     


Cys Lys Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro Gln Leu Thr 
            340                 345                 350         


Cys Val Asp Glu Arg Glu His His Arg Phe Leu Ala Ser Glu Glu Ser 
        355                 360                 365             


Gln Gly Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser Cys Pro Ile 
    370                 375                 380                 


Thr Thr Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala Met Thr Glu 
385                 390                 395                 400 


Thr Phe Val Leu Thr Met Glu Tyr Lys Gly Gly His His His His His 
                405                 410                 415     


His 
    


<210>  56
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form of IL-2 (Gly3Ser)4- extracellular 
       domain of IL-2 R + glycine spacer and poly-histidine region

<400>  56

Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Leu Cys Leu Tyr Asp Pro 
            180                 185                 190         


Pro Glu Val Pro Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly 
        195                 200                 205             


Thr Ile Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu 
    210                 215                 220                 


Leu Val Tyr Met Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln 
225                 230                 235                 240 


Cys Thr Ser Asn Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln 
                245                 250                 255     


Leu Glu His Gln Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro 
            260                 265                 270         


Thr Gln Ser Met His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro 
        275                 280                 285             


Pro Pro Trp Lys His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu 
    290                 295                 300                 


Gly Gln Ser Val His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln 
305                 310                 315                 320 


Arg Gly Pro Ala Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly 
                325                 330                 335     


Trp Thr Gln Pro Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg 
            340                 345                 350         


Phe Leu Ala Ser Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu 
        355                 360                 365             


Ser Glu Thr Ser Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr 
    370                 375                 380                 


Glu Thr Thr Ala Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys 
385                 390                 395                 400 


Gly Gly His His His His His His 
                405             


<210>  57
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized mature form of IL-2 (Gly3Ser)3- extracellular domain 
       of IL-2 R + glycine spacer and poly-histidine region

<400>  57

Met Asp Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala 
            20                  25                  30          


Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu 
        35                  40                  45              


Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn 
    50                  55                  60                  


Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu 
65                  70                  75                  80  


Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu 
                85                  90                  95      


Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe 
            100                 105                 110         


Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val 
        115                 120                 125             


Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp 
    130                 135                 140                 


Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys 
145                 150                 155                 160 


Gln Ser Ile Ile Ser Thr Ser Pro Gln Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Gly Ser Glu Leu Cys Leu Tyr Asp Pro Pro Glu Val Pro 
            180                 185                 190         


Asn Ala Thr Phe Lys Ala Leu Ser Tyr Lys Asn Gly Thr Ile Leu Asn 
        195                 200                 205             


Cys Glu Cys Lys Arg Gly Phe Arg Arg Leu Lys Glu Leu Val Tyr Met 
    210                 215                 220                 


Arg Cys Leu Gly Asn Ser Trp Ser Ser Asn Cys Gln Cys Thr Ser Asn 
225                 230                 235                 240 


Ser His Asp Lys Ser Arg Lys Gln Val Thr Ala Gln Leu Glu His Gln 
                245                 250                 255     


Lys Glu Gln Gln Thr Thr Thr Asp Met Gln Lys Pro Thr Gln Ser Met 
            260                 265                 270         


His Gln Glu Asn Leu Thr Gly His Cys Arg Glu Pro Pro Pro Trp Lys 
        275                 280                 285             


His Glu Asp Ser Lys Arg Ile Tyr His Phe Val Glu Gly Gln Ser Val 
    290                 295                 300                 


His Tyr Glu Cys Ile Pro Gly Tyr Lys Ala Leu Gln Arg Gly Pro Ala 
305                 310                 315                 320 


Ile Ser Ile Cys Lys Met Lys Cys Gly Lys Thr Gly Trp Thr Gln Pro 
                325                 330                 335     


Gln Leu Thr Cys Val Asp Glu Arg Glu His His Arg Phe Leu Ala Ser 
            340                 345                 350         


Glu Glu Ser Gln Gly Ser Arg Asn Ser Ser Pro Glu Ser Glu Thr Ser 
        355                 360                 365             


Cys Pro Ile Thr Thr Thr Asp Phe Pro Gln Pro Thr Glu Thr Thr Ala 
    370                 375                 380                 


Met Thr Glu Thr Phe Val Leu Thr Met Glu Tyr Lys Gly Gly His His 
385                 390                 395                 400 


His His His His 
                


<210>  58
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form IL-2 (Gly3Ser)2- extracellular 
       domain of IL-2 R + glycine spacer and poly-histidine region

<400>  58

Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe 
                165                 170                 175     


Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys 
            180                 185                 190         


Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr 
        195                 200                 205             


Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser 
    210                 215                 220                 


Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu 
225                 230                 235                 240 


Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val 
                245                 250                 255     


Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu 
            260                 265                 270         


Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val 
        275                 280                 285             


Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala 
    290                 295                 300                 


Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro 
305                 310                 315                 320 


Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu 
                325                 330                 335     


Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser 
            340                 345                 350         


Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala 
        355                 360                 365             


Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln Gly Gly His His 
    370                 375                 380                 


His His His His 
385             


<210>  59
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form of IL-2 (Gly3Ser)3- extracellular 
       domain of IL-2 R + glycine spacer and poly-histidine region

<400>  59

Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
                165                 170                 175     


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
            180                 185                 190         


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
        195                 200                 205             


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
    210                 215                 220                 


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
225                 230                 235                 240 


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
                245                 250                 255     


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
            260                 265                 270         


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
        275                 280                 285             


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
    290                 295                 300                 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
305                 310                 315                 320 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
                325                 330                 335     


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
            340                 345                 350         


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
        355                 360                 365             


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    370                 375                 380                 


Gly Gly His His His His His His 
385                 390         


<210>  60
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form IL-2 (Gly3Ser)4- extracellular 
       domain of IL-2 R + glycine spacer and poly-histidine region

<400>  60

Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro 
                165                 170                 175     


Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly 
            180                 185                 190         


Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser 
        195                 200                 205             


Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp 
    210                 215                 220                 


Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys 
225                 230                 235                 240 


Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu 
                245                 250                 255     


Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His 
            260                 265                 270         


Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr 
        275                 280                 285             


His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr 
    290                 295                 300                 


Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His 
305                 310                 315                 320 


Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met 
                325                 330                 335     


Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu 
            340                 345                 350         


Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe 
        355                 360                 365             


Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr 
    370                 375                 380                 


Thr Glu Tyr Gln Gly Gly His His His His His His 
385                 390                 395     


<210>  61
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form IL-2 (Gly4Ser)4- extracellular 
       domain of IL-2 R + glycine spacer and poly-histidine region

<400>  61

Met Asp Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Cys 
                165                 170                 175     


Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala 
            180                 185                 190         


Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg 
        195                 200                 205             


Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser 
    210                 215                 220                 


His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg 
225                 230                 235                 240 


Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg 
                245                 250                 255     


Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser 
            260                 265                 270         


Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr 
        275                 280                 285             


Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys 
    290                 295                 300                 


Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys 
305                 310                 315                 320 


Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys 
                325                 330                 335     


Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln 
            340                 345                 350         


Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr 
        355                 360                 365             


Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr 
    370                 375                 380                 


Ser Ile Phe Thr Thr Glu Tyr Gln Gly Gly His His His His His His 
385                 390                 395                 400 


<210>  62
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized mature form IL-2 (Gly3Ser)3- extracellular domain of 
       mutIL-2 R

<400>  62

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe 
145                 150                 155                 160 


Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys 
                165                 170                 175     


Arg Gly Phe Thr Ser Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr 
            180                 185                 190         


Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser 
        195                 200                 205             


Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu 
    210                 215                 220                 


Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val 
225                 230                 235                 240 


Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu 
                245                 250                 255     


Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val 
            260                 265                 270         


Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala 
        275                 280                 285             


Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro 
    290                 295                 300                 


Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu 
305                 310                 315                 320 


Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser 
                325                 330                 335     


Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala 
            340                 345                 350         


Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
        355                 360                 


<210>  63
<211>  1182
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form IL-2 (Gly3Ser)3- extracellular 
       domain of mutIL-2 R Mut

<400>  63
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactg gtggaggttc tggtggaggt      480

tcaggtggag gttcggagct ctgtgacgat gacccgccag agatcccaca cgccacattc      540

aaagccatgg cctacaagga aggaaccatg ttgaactgtg aatgcaagag aggtttcacc      600

tcaataaaaa gcgggtcact ctatatgctc tgtacaggaa actctagcca ctcgtcctgg      660

gacaaccaat gtcaatgcac aagctctgcc actcggaaca caacgaaaca agtgacacct      720

caacctgaag aacagaaaga aaggaaaacc acagaaatgc aaagtccaat gcagccagtg      780

gaccaagcga gccttccagg tcactgcagg gaacctccac catgggaaaa tgaagccaca      840

gagagaattt atcatttcgt ggtggggcag atggtttatt atcagtgcgt ccagggatac      900

agggctctac acagaggtcc tgctgagagc gtctgcaaaa tgacccacgg gaagacaagg      960

tggacccagc cccagctcat atgcacaggt gaaatggaga ccagtcagtt tccaggtgaa     1020

gagaagcctc aggcaagccc cgaaggccgt cctgagagtg agacttcctg cctcgtcaca     1080

acaacagatt ttcaaataca gacagaaatg gctgcaacca tggagacgtc catatttaca     1140

acagagtacc agggtggaca tcaccatcac catcactaat aa                        1182


<210>  64
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized mature form IL-2 (Gly4Ser)4- extracellular domain of 
       mutIL-2 R

<400>  64

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro 
145                 150                 155                 160 


Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly 
                165                 170                 175     


Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Thr Ser Ile Lys Ser 
            180                 185                 190         


Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp 
        195                 200                 205             


Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys 
    210                 215                 220                 


Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu 
225                 230                 235                 240 


Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His 
                245                 250                 255     


Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr 
            260                 265                 270         


His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr 
        275                 280                 285             


Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His 
    290                 295                 300                 


Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met 
305                 310                 315                 320 


Glu Thr Ser Gln Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu 
                325                 330                 335     


Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe 
            340                 345                 350         


Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr 
        355                 360                 365             


Thr Glu Tyr Gln 
    370         


<210>  65
<211>  1206
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized unprocessed form IL-2 (Gly4Ser)4- extracellular 
       domain of mutIL-2 R

<400>  65
atggacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactg gtggaggtgg atctggtgga      480

ggtggatcag gtggaggtgg atccggtgga ggtggatctg agctctgtga cgatgacccg      540

ccagagatcc cacacgccac attcaaagcc atggcctaca aggaaggaac catgttgaac      600

tgtgaatgca agagaggttt cacctcaata aaaagcgggt cactctatat gctctgtaca      660

ggaaactcta gccactcgtc ctgggacaac caatgtcaat gcacaagctc tgccactcgg      720

aacacaacga aacaagtgac acctcaacct gaagaacaga aagaaaggaa aaccacagaa      780

atgcaaagtc caatgcagcc agtggaccaa gcgagccttc caggtcactg cagggaacct      840

ccaccatggg aaaatgaagc cacagagaga atttatcatt tcgtggtggg gcagatggtt      900

tattatcagt gcgtccaggg atacagggct ctacacagag gtcctgctga gagcgtctgc      960

aaaatgaccc acgggaagac aaggtggacc cagccccagc tcatatgcac aggtgaaatg     1020

gagaccagtc agtttccagg tgaagagaag cctcaggcaa gccccgaagg ccgtcctgag     1080

agtgagactt cctgcctcgt cacaacaaca gattttcaaa tacagacaga aatggctgca     1140

accatggaga cgtccatatt tacaacagag taccagggtg gacatcacca tcaccatcac     1200

taataa                                                                1206


<210>  66
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly3Ser)6 Linker

<400>  66

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  


<210>  67
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly3Ser)7 Linker

<400>  67

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25              


<210>  68
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)6 Linker

<400>  68

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  69
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)7 Linker

<400>  69

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  70
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Gly4Ser)8 Linker

<400>  70

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  


<210>  71
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  gp100 25-33

<400>  71

Lys Val Pro Arg Asn Gln Asp Trp Leu 
1               5                   


<210>  72
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  TRP-1 106-130

<400>  72

Ser Gly His Asn Cys Gly Thr Cys Arg Pro Gly Trp Arg Gly Ala Ala 
1               5                   10                  15      


Cys Asn Gln Lys Ile Leu Thr Val Arg 
            20                  25  


<210>  73
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  B16-M27

<400>  73

Arg Glu Gly Val Glu Leu Cys Pro Gly Asn Lys Tyr Glu Met Arg Arg 
1               5                   10                  15      


His Gly Thr Thr His Ser Leu Val Ile His Asp 
            20                  25          


<210>  74
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  B16-M30

<400>  74

Pro Ser Lys Pro Ser Phe Gln Glu Phe Val Asp Trp Glu Asn Val Ser 
1               5                   10                  15      


Pro Glu Leu Asn Ser Thr Asp Gln Pro Phe Leu 
            20                  25          


<210>  75
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  B16-M44

<400>  75

Glu Phe Lys His Ile Lys Ala Phe Asp Arg Thr Phe Ala Asn Asn Pro 
1               5                   10                  15      


Gly Pro Met Val Val Phe Ala Thr Pro Gly Met 
            20                  25          


<210>  76
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  B16-M48

<400>  76

Ser His Cys His Trp Asn Asp Leu Ala Val Ile Pro Ala Gly Val Val 
1               5                   10                  15      


His Asn Trp Asp Phe Glu Pro Arg Lys Val Ser 
            20                  25          


<210>  77
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  77

Gln Gly Val Thr Val Leu Ala Val Ser Ala Val Tyr Asp Ile Phe Val 
1               5                   10                  15      


Phe His Arg Leu Lys Met Lys Gln Ile Leu Pro 
            20                  25          


<210>  78
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  78

Asn Asp Glu Pro Asp Leu Asp Pro Val Gln Glu Leu Ile Tyr Asp Leu 
1               5                   10                  15      


Arg Ser Gln Cys Asp Ala Ile Arg Val Thr Lys 
            20                  25          


<210>  79
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  79

Ala Val Lys Glu Glu Asp Ser Leu His Trp Gln Arg Pro Glu Asp Val 
1               5                   10                  15      


Gln Lys Val Lys Ala Leu Ser Phe Tyr Gln Pro 
            20                  25          


<210>  80
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  80

Phe Ala Ile Cys Phe Ser Cys Leu Leu Ala His Ala Leu Asn Leu Ile 
1               5                   10                  15      


Lys Leu Val Arg Gly Arg Lys Pro Leu Ser Trp 
            20                  25          


<210>  81
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  81

Lys Glu Leu Leu Gln Phe Lys Lys Leu Lys Lys Gln Asn Leu Gln Gln 
1               5                   10                  15      


Met Gln Ala Glu Ser Gly Phe Val Gln His Val 
            20                  25          


