                         SEQUENCE LISTING

<110>  Thomas Jefferson University
       Tykocinski, Mark  L.
       Weber, Matthew
       Smith, Carmello Romeo
 
<120>  MULTI-FUNCTIONAL FUSION PROTEINS AND USES THEREOF

<130>  205961-7028WO1(00150)

<150>  62/789,212
<151>  2019-01-07

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe 
1               5                   10                  15      


Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr 
            20                  25                  30          


Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg 
        35                  40                  45              


Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp 
    50                  55                  60                  


Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro 
65                  70                  75                  80  


Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp 
                85                  90                  95      


Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln 
            100                 105                 110         


Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala 
        115                 120                 125             


Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln 
    130                 135                 140                 


<210>  2
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe 
1               5                   10                  15      


Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr 
            20                  25                  30          


Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His Val Val Trp His Arg 
        35                  40                  45              


Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp 
    50                  55                  60                  


Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro 
65                  70                  75                  80  


Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp 
                85                  90                  95      


Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln 
            100                 105                 110         


Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala 
        115                 120                 125             


Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln 
    130                 135                 140                 


<210>  3
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Pro 
        115                 120 


<210>  4
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Trp Glu Lys Thr Val Asn Thr Glu Glu Asn Val Tyr Ala Thr Leu 
1               5                   10                  15      


Gly Ser Asp Val Asn Leu Thr Cys Gln Thr Gln Thr Val Gly Phe Phe 
            20                  25                  30          


Val Gln Met Gln Trp Ser Lys Val Thr Asn Lys Ile Asp Leu Ile Ala 
        35                  40                  45              


Val Tyr His Pro Gln Tyr Gly Phe Tyr Cys Ala Tyr Gly Arg Pro Cys 
    50                  55                  60                  


Glu Ser Leu Val Thr Phe Thr Glu Thr Pro Glu Asn Gly Ser Lys Trp 
65                  70                  75                  80  


Thr Leu His Leu Arg Asn Met Ser Cys Ser Val Ser Gly Arg Tyr Glu 
                85                  90                  95      


Cys Met Leu Val Leu Tyr Pro Glu Gly Ile Gln Thr Lys Ile Tyr Asn 
            100                 105                 110         


Leu Leu Ile Gln Thr His Val Thr Ala Asp Glu Trp Asn Ser Asn His 
        115                 120                 125             


Thr Ile Glu Ile Glu Ile Asn Gln Thr Leu Glu Ile Pro Cys Phe Gln 
    130                 135                 140                 


Asn Ser Ser Ser Lys Ile Ser Ser Glu Phe Thr Tyr Ala Trp Ser Val 
145                 150                 155                 160 


Glu Asn Ser Ser Thr Asp Ser Trp Val Leu Leu Ser Lys Gly Ile Lys 
                165                 170                 175     


Glu Asp Asn Gly Thr Gln Glu Thr Leu Ile Ser Gln Asn His Leu Ile 
            180                 185                 190         


Ser Asn Ser Thr Leu Leu Lys Asp Arg Val Lys Leu Gly Thr Asp Tyr 
        195                 200                 205             


Arg Leu His Leu Ser Pro Val Gln Ile Phe Asp Asp Gly Arg Lys Phe 
    210                 215                 220                 


Ser Cys His Ile Arg Val Gly Pro Asn Lys Ile Leu Arg Ser Ser Thr 
225                 230                 235                 240 


Thr Val Lys Val Phe Ala Lys Pro Glu Ile Pro Val Ile Val Glu Asn 
                245                 250                 255     


Asn Ser Thr Asp Val Leu Val Glu Arg Arg Phe Thr Cys Leu Leu Lys 
            260                 265                 270         


Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe Ile Asp Gly Ser Phe 
        275                 280                 285             


Leu His Asp Glu Lys Glu Gly Ile Tyr Ile Thr Asn Glu Glu Arg Lys 
    290                 295                 300                 


Gly Lys Asp Gly Phe Leu Glu Leu Lys Ser Val Leu Thr Arg Val His 
305                 310                 315                 320 


Ser Asn Lys Pro Ala Gln Ser Asp Asn Leu Thr Ile Trp Cys Met Ala 
                325                 330                 335     


Leu Ser Pro Val Pro Gly Asn Lys Val Trp Asn Ile Ser Ser Glu Lys 
            340                 345                 350         


Ile Thr Phe Leu Leu Gly Ser Glu Ile Ser Ser Thr Asp Pro Pro Leu 
        355                 360                 365             


Ser Val Thr Glu Ser Thr Leu Asp Thr Gln Pro Ser Pro Ala Ser Ser 
    370                 375                 380                 


Val Ser Pro Ala Arg Tyr Pro Ala Thr Ser Ser Val Thr Leu Val Asp 
385                 390                 395                 400 


Val Ser Ala Leu Arg Pro Asn Thr Thr Pro Gln Pro Ser Asn Ser Ser 
                405                 410                 415     


Met Thr Thr Arg Gly Phe Asn Tyr Pro Trp Thr Ser Ser Gly Thr Asp 
            420                 425                 430         


Thr Lys Lys Ser Val Ser Arg Ile Pro Ser Glu Thr Tyr Ser Ser Ser 
        435                 440                 445             


Pro Ser Gly Ala Gly Ser Thr Leu His Asp Asn Val Phe Thr Ser Thr 
    450                 455                 460                 


Ala Arg Ala Phe Ser Glu Val Pro Thr Thr Ala Asn Gly Ser Thr Lys 
465                 470                 475                 480 


Thr Asn His Val His Ile Thr Gly Ile Val Val Asn Lys Pro Lys Asp 
                485                 490                 495     


Gly Met 
        


<210>  5
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly His Arg Thr Leu Val Leu Pro Trp Val Leu Leu Thr Leu Cys 
1               5                   10                  15      


Val Thr Ala Gly Thr Pro Glu Val Trp Val Gln Val Arg Met Glu Ala 
            20                  25                  30          


Thr Glu Leu Ser Ser Phe Thr Ile Arg Cys Gly Phe Leu Gly Ser Gly 
        35                  40                  45              


Ser Ile Ser Leu Val Thr Val Ser Trp Gly Gly Pro Asn Gly Ala Gly 
    50                  55                  60                  


Gly Thr Thr Leu Ala Val Leu His Pro Glu Arg Gly Ile Arg Gln Trp 
65                  70                  75                  80  


Ala Pro Ala Arg Gln Ala Arg Trp Glu Thr Gln Ser Ser Ile Ser Leu 
                85                  90                  95      


Ile Leu Glu Gly Ser Gly Ala Ser Ser Pro Cys Ala Asn Thr Thr Phe 
            100                 105                 110         


Cys Cys Lys Phe Ala Ser Phe Pro Glu Gly Ser Trp Glu Ala Cys Gly 
        115                 120                 125             


Ser Leu Pro Pro Ser Ser Asp Pro Gly Leu Ser Ala Pro Pro Thr Pro 
    130                 135                 140                 


Ala Pro Ile Leu Arg Ala Asp 
145                 150     


<210>  6
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn Met Ser 
1               5                   10                  15      


Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val Glu Trp 
            20                  25                  30          


Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser Pro Thr 
        35                  40                  45              


His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr Phe Leu 
    50                  55                  60                  


Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg Asn Ala 
65                  70                  75                  80  


Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr Tyr Pro 
                85                  90                  95      


Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp Ser Phe 
            100                 105                 110         


Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro Gly Lys 
        115                 120                 125             


Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val Gln Ala 
    130                 135                 140                 


Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu Thr Tyr 
145                 150                 155                 160 


Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro Arg Gln 
                165                 170                 175     


Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val Ile Pro 
            180                 185                 190         


Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu Gln Ala 
        195                 200                 205             


Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val Ala Glu 
    210                 215                 220                 


Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala 
225                 230                 235     


<210>  7
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Asn Leu Phe Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala 
1               5                   10                  15      


Thr Ile Ser Cys Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu 
            20                  25                  30          


Leu Asn Pro Asn Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu 
        35                  40                  45              


Lys Asp Ser Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys 
    50                  55                  60                  


Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys 
65                  70                  75                  80  


Gln Leu Tyr Thr Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val 
                85                  90                  95      


Leu Val Pro Pro Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala 
            100                 105                 110         


Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys 
        115                 120                 125             


Pro Ala Thr Thr Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly 
    130                 135                 140                 


Lys Ser Glu Val Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln 
145                 150                 155                 160 


Leu Met Leu Lys Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys 
                165                 170                 175     


Gln Val Glu His Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr 
            180                 185                 190         


Leu Glu Val Gln Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro 
        195                 200                 205             


Leu Gln Gly Leu Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu 
    210                 215                 220                 


Ala Ile Gly Lys Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp 
225                 230                 235                 240 


Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile 
                245                 250                 255     


Asn Asn Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser 
            260                 265                 270         


Asn Ile Val Gly Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp 
        275                 280                 285             


Pro Pro Thr Thr Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr 
    290                 295                 300                 


Thr Thr Thr Thr Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg Ala Gly 
305                 310                 315                 320 


Glu Glu Gly Ser Ile Arg Ala Val Asp His 
                325                 330 


<210>  8
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  8

Pro Ile Ile Val Glu Pro His Val Thr Ala Val Trp Gly Lys Asn Val 
1               5                   10                  15      


Ser Leu Lys Cys Leu Ile Glu Val Asn Glu Thr Ile Thr Gln Ile Ser 
            20                  25                  30          


Trp Glu Lys Ile His Gly Lys Ser Ser Gln Thr Val Ala Val His His 
        35                  40                  45              


Pro Gln Tyr Gly Phe Ser Val Gln Gly Glu Tyr Gln Gly Arg Val Leu 
    50                  55                  60                  


Phe Lys Asn Tyr Ser Leu Asn Asp Ala Thr Ile Thr Leu His Asn Ile 
65                  70                  75                  80  


Gly Phe Ser Asp Ser Gly Lys Tyr Ile Cys Lys Ala Val Thr Phe Pro 
                85                  90                  95      


Leu Gly Asn Ala Gln Ser Ser Thr Thr Val Thr Val Leu Val Glu Pro 
            100                 105                 110         


Thr Val Ser Leu Ile Lys Gly Pro Asp Ser Leu Ile Asp Gly Gly Asn 
        115                 120                 125             


Glu Thr Val Ala Ala Ile Cys Ile Ala Ala Thr Gly Lys Pro Val Ala 
    130                 135                 140                 


His Ile Asp Trp Glu Gly Asp Leu Gly Glu Met Glu Ser Thr Thr Thr 
145                 150                 155                 160 


Ser Phe Pro Asn Glu Thr Ala Thr Ile Ile Ser Gln Tyr Lys Leu Phe 
                165                 170                 175     


Pro Thr Arg Phe Ala Arg Gly Arg Arg Ile Thr Cys Val Val Lys His 
            180                 185                 190         


Pro Ala Leu Glu Lys Asp Ile Arg Tyr Ser Phe Ile Leu Asp Ile Gln 
        195                 200                 205             


Tyr Ala Pro Glu Val Ser Val Thr Gly Tyr Asp Gly Asn Trp Phe Val 
    210                 215                 220                 


Gly Arg Lys Gly Val Asn Leu Lys Cys Asn Ala Asp Ala Asn Pro Pro 
225                 230                 235                 240 


Pro Phe Lys Ser Val Trp Ser Arg Leu Asp Gly Gln Trp Pro Asp Gly 
                245                 250                 255     


Leu Leu Ala Ser Asp Asn Thr Leu His Phe Val His Pro Leu Thr Phe 
            260                 265                 270         


Asn Tyr Ser Gly Val Tyr Ile Cys Lys Val Thr Asn Ser Leu Gly Gln 
        275                 280                 285             


Arg Ser Asp Gln Lys Val Ile Tyr Ile Ser Asp Pro Pro Thr Thr Thr 
    290                 295                 300                 


Thr Leu Gln Pro Thr Ile Gln Trp His Pro Ser Thr Ala Asp Ile Glu 
305                 310                 315                 320 


Asp Leu Ala Thr Glu Pro Lys Lys Leu Pro Phe Pro Leu Ser Thr Leu 
                325                 330                 335     


Ala Thr Ile Lys Asp Asp 
            340         


<210>  9
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp Asp 
1               5                   10                  15      


Gly Ser Val Gln Ser Gly Phe Leu Thr Glu Val His Leu Asp Gly Gln 
            20                  25                  30          


Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln Gly 
        35                  40                  45              


Gln Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala His 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg Val 
                85                  90                  95      


Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe Tyr 
            100                 105                 110         


Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Lys Glu Trp 
        115                 120                 125             


Thr Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val Arg 
    130                 135                 140                 


Asn Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His Ala 
145                 150                 155                 160 


Met His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser Gly 
                165                 170                 175     


Val Val Leu Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Arg Ser 
            180                 185                 190         


Glu Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Gly Phe 
        195                 200                 205             


Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln Asp Gly Val Ser Leu 
    210                 215                 220                 


Ser His Asp Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn Gly 
225                 230                 235                 240 


Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys Gln Gly Glu Glu Gln 
                245                 250                 255     


Arg Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His Pro 
            260                 265                 270         


Val Pro Ser Gly Lys Val Leu Val Leu Gln Ser His Trp 
        275                 280                 285 


<210>  10
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  11
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  12
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  12

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
1               5                   10                  15      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            20                  25                  30          


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        35                  40                  45              


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    50                  55                  60                  


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
65                  70                  75                  80  


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                85                  90                  95      


Lys Thr Ile Ser Lys Ala Lys 
            100             


<210>  13
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  14
<211>  396
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human PD-1-hFcA

<400>  14

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ala Ser Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn 
            20                  25                  30          


Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn 
        35                  40                  45              


Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu 
    50                  55                  60                  


Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala 
65                  70                  75                  80  


Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val 
                85                  90                  95      


Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala 
            100                 105                 110         


Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala 
        115                 120                 125             


Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
    130                 135                 140                 


Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg 
145                 150                 155                 160 


Pro Ala Gly Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
                165                 170                 175     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            180                 185                 190         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        195                 200                 205             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    210                 215                 220                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
225                 230                 235                 240 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                245                 250                 255     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val 
            260                 265                 270         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        275                 280                 285             


Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
    290                 295                 300                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
305                 310                 315                 320 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                325                 330                 335     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            340                 345                 350         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        355                 360                 365             


Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His 
    370                 375                 380                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390                 395     


<210>  15
<211>  396
<212>  PRT
<213>  Artificial sequence

<220>
<223>  High affinity human PD-1-hFcA

<400>  15

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ala Ser Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn 
            20                  25                  30          


Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn 
        35                  40                  45              


Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His Val 
    50                  55                  60                  


Val Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala Ala 
65                  70                  75                  80  


Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val 
                85                  90                  95      


Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala 
            100                 105                 110         


Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu Ala 
        115                 120                 125             


Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
    130                 135                 140                 


Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg 
145                 150                 155                 160 


Pro Ala Gly Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
                165                 170                 175     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            180                 185                 190         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        195                 200                 205             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    210                 215                 220                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
225                 230                 235                 240 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                245                 250                 255     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val 
            260                 265                 270         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        275                 280                 285             


Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
    290                 295                 300                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
305                 310                 315                 320 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                325                 330                 335     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            340                 345                 350         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        355                 360                 365             


Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His 
    370                 375                 380                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390                 395     


<210>  16
<211>  403
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human CD112R-hFcA

<400>  16

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ala Ser Met Gly His Arg Thr Leu Val Leu Pro Trp Val Leu 
            20                  25                  30          


Leu Thr Leu Cys Val Thr Ala Gly Thr Pro Glu Val Trp Val Gln Val 
        35                  40                  45              


Arg Met Glu Ala Thr Glu Leu Ser Ser Phe Thr Ile Arg Cys Gly Phe 
    50                  55                  60                  


Leu Gly Ser Gly Ser Ile Ser Leu Val Thr Val Ser Trp Gly Gly Pro 
65                  70                  75                  80  


Asn Gly Ala Gly Gly Thr Thr Leu Ala Val Leu His Pro Glu Arg Gly 
                85                  90                  95      


Ile Arg Gln Trp Ala Pro Ala Arg Gln Ala Arg Trp Glu Thr Gln Ser 
            100                 105                 110         


Ser Ile Ser Leu Ile Leu Glu Gly Ser Gly Ala Ser Ser Pro Cys Ala 
        115                 120                 125             


Asn Thr Thr Phe Cys Cys Lys Phe Ala Ser Phe Pro Glu Gly Ser Trp 
    130                 135                 140                 


Glu Ala Cys Gly Ser Leu Pro Pro Ser Ser Asp Pro Gly Leu Ser Ala 
145                 150                 155                 160 


Pro Pro Thr Pro Ala Pro Ile Leu Arg Ala Asp Glu Pro Lys Ser Ser 
                165                 170                 175     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            180                 185                 190         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        195                 200                 205             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    210                 215                 220                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
225                 230                 235                 240 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                245                 250                 255     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            260                 265                 270         


Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        275                 280                 285             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    290                 295                 300                 


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
305                 310                 315                 320 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                325                 330                 335     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            340                 345                 350         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        355                 360                 365             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu 
    370                 375                 380                 


His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
385                 390                 395                 400 


Pro Gly Lys 
            


<210>  17
<211>  370
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human TIGIT-hFcA

<400>  17

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala 
            20                  25                  30          


Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr 
        35                  40                  45              


Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala 
    50                  55                  60                  


Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp 
65                  70                  75                  80  


Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr 
                85                  90                  95      


Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp 
            100                 105                 110         


Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val 
        115                 120                 125             


Ala Glu His Gly Ala Arg Phe Gln Ile Pro Glu Pro Lys Ser Ser Asp 
    130                 135                 140                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
145                 150                 155                 160 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                165                 170                 175     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            180                 185                 190         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        195                 200                 205             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    210                 215                 220                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
225                 230                 235                 240 


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                245                 250                 255     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 
            260                 265                 270         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        275                 280                 285             


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    290                 295                 300                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
305                 310                 315                 320 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                325                 330                 335     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His 
            340                 345                 350         


Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        355                 360                 365             


Gly Lys 
    370 


<210>  18
<211>  748
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human CD96-hFcA

<400>  18

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Val Trp Glu Lys Thr Val Asn Thr Glu Glu Asn Val Tyr Ala 
            20                  25                  30          


Thr Leu Gly Ser Asp Val Asn Leu Thr Cys Gln Thr Gln Thr Val Gly 
        35                  40                  45              


Phe Phe Val Gln Met Gln Trp Ser Lys Val Thr Asn Lys Ile Asp Leu 
    50                  55                  60                  


Ile Ala Val Tyr His Pro Gln Tyr Gly Phe Tyr Cys Ala Tyr Gly Arg 
65                  70                  75                  80  


Pro Cys Glu Ser Leu Val Thr Phe Thr Glu Thr Pro Glu Asn Gly Ser 
                85                  90                  95      


Lys Trp Thr Leu His Leu Arg Asn Met Ser Cys Ser Val Ser Gly Arg 
            100                 105                 110         


Tyr Glu Cys Met Leu Val Leu Tyr Pro Glu Gly Ile Gln Thr Lys Ile 
        115                 120                 125             


Tyr Asn Leu Leu Ile Gln Thr His Val Thr Ala Asp Glu Trp Asn Ser 
    130                 135                 140                 


Asn His Thr Ile Glu Ile Glu Ile Asn Gln Thr Leu Glu Ile Pro Cys 
145                 150                 155                 160 


Phe Gln Asn Ser Ser Ser Lys Ile Ser Ser Glu Phe Thr Tyr Ala Trp 
                165                 170                 175     


Ser Val Glu Asn Ser Ser Thr Asp Ser Trp Val Leu Leu Ser Lys Gly 
            180                 185                 190         


Ile Lys Glu Asp Asn Gly Thr Gln Glu Thr Leu Ile Ser Gln Asn His 
        195                 200                 205             


Leu Ile Ser Asn Ser Thr Leu Leu Lys Asp Arg Val Lys Leu Gly Thr 
    210                 215                 220                 


Asp Tyr Arg Leu His Leu Ser Pro Val Gln Ile Phe Asp Asp Gly Arg 
225                 230                 235                 240 


Lys Phe Ser Cys His Ile Arg Val Gly Pro Asn Lys Ile Leu Arg Ser 
                245                 250                 255     


Ser Thr Thr Val Lys Val Phe Ala Lys Pro Glu Ile Pro Val Ile Val 
            260                 265                 270         


Glu Asn Asn Ser Thr Asp Val Leu Val Glu Arg Arg Phe Thr Cys Leu 
        275                 280                 285             


Leu Lys Asn Val Phe Pro Lys Ala Asn Ile Thr Trp Phe Ile Asp Gly 
    290                 295                 300                 


Ser Phe Leu His Asp Glu Lys Glu Gly Ile Tyr Ile Thr Asn Glu Glu 
305                 310                 315                 320 


Arg Lys Gly Lys Asp Gly Phe Leu Glu Leu Lys Ser Val Leu Thr Arg 
                325                 330                 335     


Val His Ser Asn Lys Pro Ala Gln Ser Asp Asn Leu Thr Ile Trp Cys 
            340                 345                 350         


Met Ala Leu Ser Pro Val Pro Gly Asn Lys Val Trp Asn Ile Ser Ser 
        355                 360                 365             


Glu Lys Ile Thr Phe Leu Leu Gly Ser Glu Ile Ser Ser Thr Asp Pro 
    370                 375                 380                 


Pro Leu Ser Val Thr Glu Ser Thr Leu Asp Thr Gln Pro Ser Pro Ala 
385                 390                 395                 400 


Ser Ser Val Ser Pro Ala Arg Tyr Pro Ala Thr Ser Ser Val Thr Leu 
                405                 410                 415     


Val Asp Val Ser Ala Leu Arg Pro Asn Thr Thr Pro Gln Pro Ser Asn 
            420                 425                 430         


Ser Ser Met Thr Thr Arg Gly Phe Asn Tyr Pro Trp Thr Ser Ser Gly 
        435                 440                 445             


Thr Asp Thr Lys Lys Ser Val Ser Arg Ile Pro Ser Glu Thr Tyr Ser 
    450                 455                 460                 


Ser Ser Pro Ser Gly Ala Gly Ser Thr Leu His Asp Asn Val Phe Thr 
465                 470                 475                 480 


Ser Thr Ala Arg Ala Phe Ser Glu Val Pro Thr Thr Ala Asn Gly Ser 
                485                 490                 495     


Thr Lys Thr Asn His Val His Ile Thr Gly Ile Val Val Asn Lys Pro 
            500                 505                 510         


Lys Asp Gly Met Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
        515                 520                 525             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    530                 535                 540                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
545                 550                 555                 560 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                565                 570                 575     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            580                 585                 590         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        595                 600                 605             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val 
    610                 615                 620                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
625                 630                 635                 640 


Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
                645                 650                 655     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
            660                 665                 670         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        675                 680                 685             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    690                 695                 700                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
705                 710                 715                 720 


Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His 
                725                 730                 735     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745             


<210>  19
<211>  486
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human CD226-hFcA

<400>  19

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn 
            20                  25                  30          


Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val 
        35                  40                  45              


Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser 
    50                  55                  60                  


Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr 
65                  70                  75                  80  


Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg 
                85                  90                  95      


Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr 
            100                 105                 110         


Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp 
        115                 120                 125             


Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro 
    130                 135                 140                 


Gly Lys Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val 
145                 150                 155                 160 


Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu 
                165                 170                 175     


Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro 
            180                 185                 190         


Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val 
        195                 200                 205             


Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu 
    210                 215                 220                 


Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val 
225                 230                 235                 240 


Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Glu Pro 
                245                 250                 255     


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            260                 265                 270         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        275                 280                 285             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    290                 295                 300                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
305                 310                 315                 320 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                325                 330                 335     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            340                 345                 350         


Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro 
        355                 360                 365             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    370                 375                 380                 


Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
385                 390                 395                 400 


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                405                 410                 415     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            420                 425                 430         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        435                 440                 445             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    450                 455                 460                 


Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu 
465                 470                 475                 480 


Ser Leu Ser Pro Gly Lys 
                485     


<210>  20
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human NECL2-hFcA

<400>  20

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Asn Leu Phe Thr Lys Asp Val Thr Val Ile Glu Gly Glu 
            20                  25                  30          


Val Ala Thr Ile Ser Cys Gln Val Asn Lys Ser Asp Asp Ser Val Ile 
        35                  40                  45              


Gln Leu Leu Asn Pro Asn Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg 
    50                  55                  60                  


Pro Leu Lys Asp Ser Arg Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu 
65                  70                  75                  80  


Leu Lys Val Ser Leu Thr Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr 
                85                  90                  95      


Phe Cys Gln Leu Tyr Thr Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile 
            100                 105                 110         


Thr Val Leu Val Pro Pro Arg Asn Leu Met Ile Asp Ile Gln Lys Asp 
        115                 120                 125             


Thr Ala Val Glu Gly Glu Glu Ile Glu Val Asn Cys Thr Ala Met Ala 
    130                 135                 140                 


Ser Lys Pro Ala Thr Thr Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu 
145                 150                 155                 160 


Lys Gly Lys Ser Glu Val Glu Glu Trp Ser Asp Met Tyr Thr Val Thr 
                165                 170                 175     


Ser Gln Leu Met Leu Lys Val His Lys Glu Asp Asp Gly Val Pro Val 
            180                 185                 190         


Ile Cys Gln Val Glu His Pro Ala Val Thr Gly Asn Leu Gln Thr Gln 
        195                 200                 205             


Arg Tyr Leu Glu Val Gln Tyr Lys Pro Gln Val His Ile Gln Met Thr 
    210                 215                 220                 


Tyr Pro Leu Gln Gly Leu Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr 
225                 230                 235                 240 


Cys Glu Ala Ile Gly Lys Pro Gln Pro Val Met Val Thr Trp Val Arg 
                245                 250                 255     


Val Asp Asp Glu Met Pro Gln His Ala Val Leu Ser Gly Pro Asn Leu 
            260                 265                 270         


Phe Ile Asn Asn Leu Asn Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu 
        275                 280                 285             


Ala Ser Asn Ile Val Gly Lys Ala His Ser Asp Tyr Met Leu Tyr Val 
    290                 295                 300                 


Tyr Asp Pro Pro Thr Thr Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr 
305                 310                 315                 320 


Thr Thr Thr Thr Thr Thr Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg 
                325                 330                 335     


Ala Gly Glu Glu Gly Ser Ile Arg Ala Val Asp His Glu Pro Lys Ser 
            340                 345                 350         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        355                 360                 365             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    370                 375                 380                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
385                 390                 395                 400 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                405                 410                 415     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            420                 425                 430         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        435                 440                 445             


Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
    450                 455                 460                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
465                 470                 475                 480 


Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
                485                 490                 495     


Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            500                 505                 510         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        515                 520                 525             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    530                 535                 540                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
545                 550                 555                 560 


Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu 
                565                 570                 575     


Ser Pro Gly Lys 
            580 


<210>  21
<211>  594
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human CD113-hFcA

<400>  21

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ala Ser Pro Ile Ile Val Glu Pro His Val Thr Ala Val Trp 
            20                  25                  30          


Gly Lys Asn Val Ser Leu Lys Cys Leu Ile Glu Val Asn Glu Thr Ile 
        35                  40                  45              


Thr Gln Ile Ser Trp Glu Lys Ile His Gly Lys Ser Ser Gln Thr Val 
    50                  55                  60                  


Ala Val His His Pro Gln Tyr Gly Phe Ser Val Gln Gly Glu Tyr Gln 
65                  70                  75                  80  


Gly Arg Val Leu Phe Lys Asn Tyr Ser Leu Asn Asp Ala Thr Ile Thr 
                85                  90                  95      


Leu His Asn Ile Gly Phe Ser Asp Ser Gly Lys Tyr Ile Cys Lys Ala 
            100                 105                 110         


Val Thr Phe Pro Leu Gly Asn Ala Gln Ser Ser Thr Thr Val Thr Val 
        115                 120                 125             


Leu Val Glu Pro Thr Val Ser Leu Ile Lys Gly Pro Asp Ser Leu Ile 
    130                 135                 140                 


Asp Gly Gly Asn Glu Thr Val Ala Ala Ile Cys Ile Ala Ala Thr Gly 
145                 150                 155                 160 


Lys Pro Val Ala His Ile Asp Trp Glu Gly Asp Leu Gly Glu Met Glu 
                165                 170                 175     


Ser Thr Thr Thr Ser Phe Pro Asn Glu Thr Ala Thr Ile Ile Ser Gln 
            180                 185                 190         


Tyr Lys Leu Phe Pro Thr Arg Phe Ala Arg Gly Arg Arg Ile Thr Cys 
        195                 200                 205             


Val Val Lys His Pro Ala Leu Glu Lys Asp Ile Arg Tyr Ser Phe Ile 
    210                 215                 220                 


Leu Asp Ile Gln Tyr Ala Pro Glu Val Ser Val Thr Gly Tyr Asp Gly 
225                 230                 235                 240 


Asn Trp Phe Val Gly Arg Lys Gly Val Asn Leu Lys Cys Asn Ala Asp 
                245                 250                 255     


Ala Asn Pro Pro Pro Phe Lys Ser Val Trp Ser Arg Leu Asp Gly Gln 
            260                 265                 270         


Trp Pro Asp Gly Leu Leu Ala Ser Asp Asn Thr Leu His Phe Val His 
        275                 280                 285             


Pro Leu Thr Phe Asn Tyr Ser Gly Val Tyr Ile Cys Lys Val Thr Asn 
    290                 295                 300                 


Ser Leu Gly Gln Arg Ser Asp Gln Lys Val Ile Tyr Ile Ser Asp Pro 
305                 310                 315                 320 


Pro Thr Thr Thr Thr Leu Gln Pro Thr Ile Gln Trp His Pro Ser Thr 
                325                 330                 335     


Ala Asp Ile Glu Asp Leu Ala Thr Glu Pro Lys Lys Leu Pro Phe Pro 
            340                 345                 350         


Leu Ser Thr Leu Ala Thr Ile Lys Asp Asp Glu Pro Lys Ser Ser Asp 
        355                 360                 365             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    370                 375                 380                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
385                 390                 395                 400 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                405                 410                 415     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            420                 425                 430         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        435                 440                 445             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    450                 455                 460                 


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
465                 470                 475                 480 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 
                485                 490                 495     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            500                 505                 510         


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        515                 520                 525             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    530                 535                 540                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
545                 550                 555                 560 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His 
                565                 570                 575     


Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            580                 585                 590         


Gly Lys 
        


<210>  22
<211>  537
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human MICA-hFcA

<400>  22

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ala Ser Ala Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val 
            20                  25                  30          


Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Thr Glu Val His 
        35                  40                  45              


Leu Asp Gly Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala 
    50                  55                  60                  


Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp 
65                  70                  75                  80  


Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met 
                85                  90                  95      


Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln 
            100                 105                 110         


Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser 
        115                 120                 125             


Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu 
    130                 135                 140                 


Thr Lys Glu Trp Thr Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala 
145                 150                 155                 160 


Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr 
                165                 170                 175     


His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr 
            180                 185                 190         


Leu Lys Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met Val Asn 
        195                 200                 205             


Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg 
    210                 215                 220                 


Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln Asp 
225                 230                 235                 240 


Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val Leu Pro 
                245                 250                 255     


Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys Gln 
            260                 265                 270         


Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly Asn His 
        275                 280                 285             


Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln Ser His 
    290                 295                 300                 


Trp Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
305                 310                 315                 320 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                325                 330                 335     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            340                 345                 350         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        355                 360                 365             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    370                 375                 380                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
385                 390                 395                 400 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 
                405                 410                 415     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            420                 425                 430         


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        435                 440                 445             


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
    450                 455                 460                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
465                 470                 475                 480 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                485                 490                 495     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            500                 505                 510         


Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln 
        515                 520                 525             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    530                 535         


<210>  23
<211>  252
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human FcA

<400>  23

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ala Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250         


<210>  24
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  24

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Met 
305                 310                 315                 320 


Ser Arg Asn 
            


<210>  25
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Pro 
        115                 120 


<210>  26
<211>  170
<212>  PRT
<213>  Mus musculus

<400>  26

Leu Glu Asp Gly Tyr Lys Val Glu Val Gly Lys Asn Ala Tyr Leu Pro 
1               5                   10                  15      


Cys Ser Tyr Thr Leu Pro Thr Ser Gly Thr Leu Val Pro Met Cys Trp 
            20                  25                  30          


Gly Lys Gly Phe Cys Pro Trp Ser Gln Cys Thr Asn Glu Leu Leu Arg 
        35                  40                  45              


Thr Asp Glu Arg Asn Val Thr Tyr Gln Lys Ser Ser Arg Tyr Gln Leu 
    50                  55                  60                  


Lys Gly Asp Leu Asn Lys Gly Asp Val Ser Leu Ile Ile Lys Asn Val 
65                  70                  75                  80  


Thr Leu Asp Asp His Gly Thr Tyr Cys Cys Arg Ile Gln Phe Pro Gly 
                85                  90                  95      


Leu Met Asn Asp Lys Lys Leu Glu Leu Lys Leu Asp Ile Lys Ala Ala 
            100                 105                 110         


Lys Val Thr Pro Ala Gln Thr Ala His Gly Asp Ser Thr Thr Ala Ser 
        115                 120                 125             


Pro Arg Thr Leu Thr Thr Glu Arg Asn Gly Ser Glu Thr Gln Thr Leu 
    130                 135                 140                 


Val Thr Leu His Asn Asn Asn Gly Thr Lys Ile Ser Thr Trp Ala Asp 
145                 150                 155                 160 


Glu Ile Lys Asp Ser Gly Glu Thr Ile Arg 
                165                 170 


<210>  27
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  27

Pro Ile Ile Val Glu Pro His Val Thr Ala Val Trp Gly Lys Asn Val 
1               5                   10                  15      


Ser Leu Lys Cys Leu Ile Glu Val Asn Glu Thr Ile Thr Gln Ile Ser 
            20                  25                  30          


Trp Glu Lys Ile His Gly Lys Ser Ser Gln Thr Val Ala Val His His 
        35                  40                  45              


Pro Gln Tyr Gly Phe Ser Val Gln Gly Glu Tyr Gln Gly Arg Val Leu 
    50                  55                  60                  


Phe Lys Asn Tyr Ser Leu Asn Asp Ala Thr Ile Thr Leu His Asn Ile 
65                  70                  75                  80  


Gly Phe Ser Asp Ser Gly Lys Tyr Ile Cys Lys Ala Val Thr Phe Pro 
                85                  90                  95      


Leu Gly Asn Ala Gln Ser Ser Thr Thr Val Thr Val Leu Val Glu Pro 
            100                 105                 110         


Thr Val Ser Leu Ile Lys Gly Pro Asp Ser Leu Ile Asp Gly Gly Asn 
        115                 120                 125             


Glu Thr Val Ala Ala Ile Cys Ile Ala Ala Thr Gly Lys Pro Val Ala 
    130                 135                 140                 


His Ile Asp Trp Glu Gly Asp Leu Gly Glu Met Glu Ser Thr Thr Thr 
145                 150                 155                 160 


Ser Phe Pro Asn Glu Thr Ala Thr Ile Ile Ser Gln Tyr Lys Leu Phe 
                165                 170                 175     


Pro Thr Arg Phe Ala Arg Gly Arg Arg Ile Thr Cys Val Val Lys His 
            180                 185                 190         


Pro Ala Leu Glu Lys Asp Ile Arg Tyr Ser Phe Ile Leu Asp Ile Gln 
        195                 200                 205             


Tyr Ala Pro Glu Val Ser Val Thr Gly Tyr Asp Gly Asn Trp Phe Val 
    210                 215                 220                 


Gly Arg Lys Gly Val Asn Leu Lys Cys Asn Ala Asp Ala Asn Pro Pro 
225                 230                 235                 240 


Pro Phe Lys Ser Val Trp Ser Arg Leu Asp Gly Gln Trp Pro Asp Gly 
                245                 250                 255     


Leu Leu Ala Ser Asp Asn Thr Leu His Phe Val His Pro Leu Thr Phe 
            260                 265                 270         


Asn Tyr Ser Gly Val Tyr Ile Cys Lys Val Thr Asn Ser Leu Gly Gln 
        275                 280                 285             


Arg Ser Asp Gln Lys Val Ile Tyr Ile Ser Asp Pro Pro Thr Thr Thr 
    290                 295                 300                 


Thr Leu Gln Pro Thr Ile Gln Trp His Pro Ser Thr Ala Asp Ile Glu 
305                 310                 315                 320 


Asp Leu Ala Thr Glu Pro Lys Lys Leu Pro Phe Pro Leu Ser Thr Leu 
                325                 330                 335     


Ala Thr Ile Lys Asp Asp 
            340         


<210>  28
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  28

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  29
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Component A Y349C and T366W

<400>  29

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Asn Ser Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  30
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Component B D356C, T366S, L368A and Y407V

<400>  30

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Cys Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  31
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  31

Gly Asp Pro Leu Val Thr Ala Ala Ser Val Leu Glu Phe Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
            20                  25                  30          


Gly Gly Ser Asp Ile 
        35          


<210>  32
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human CD155-hFcB

<400>  32

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ala Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Met Ser Arg Asn Glu Pro Lys Ser Ser Asp Lys Thr His 
            340                 345                 350         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        355                 360                 365             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    370                 375                 380                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
385                 390                 395                 400 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                405                 410                 415     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            420                 425                 430         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        435                 440                 445             


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    450                 455                 460                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
465                 470                 475                 480 


Pro Ser Arg Cys Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
                485                 490                 495     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            500                 505                 510         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        515                 520                 525             


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
    530                 535                 540                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu 
545                 550                 555                 560 


His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                565                 570                 575 


<210>  33
<211>  372
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human TIGIT-hFcB

<400>  33

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ala Ser Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile 
            20                  25                  30          


Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser 
        35                  40                  45              


Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu 
    50                  55                  60                  


Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe 
65                  70                  75                  80  


Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser 
                85                  90                  95      


Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr 
            100                 105                 110         


Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser 
        115                 120                 125             


Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Glu Pro Lys Ser 
    130                 135                 140                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  34
<211>  422
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Mouse TIM-3-hFcB

<400>  34

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ala Ser Leu Glu Asp Gly Tyr Lys Val Glu Val Gly Lys Asn 
            20                  25                  30          


Ala Tyr Leu Pro Cys Ser Tyr Thr Leu Pro Thr Ser Gly Thr Leu Val 
        35                  40                  45              


Pro Met Cys Trp Gly Lys Gly Phe Cys Pro Trp Ser Gln Cys Thr Asn 
    50                  55                  60                  


Glu Leu Leu Arg Thr Asp Glu Arg Asn Val Thr Tyr Gln Lys Ser Ser 
65                  70                  75                  80  


Arg Tyr Gln Leu Lys Gly Asp Leu Asn Lys Gly Asp Val Ser Leu Ile 
                85                  90                  95      


Ile Lys Asn Val Thr Leu Asp Asp His Gly Thr Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Phe Pro Gly Leu Met Asn Asp Lys Lys Leu Glu Leu Lys Leu Asp 
        115                 120                 125             


Ile Lys Ala Ala Lys Val Thr Pro Ala Gln Thr Ala His Gly Asp Ser 
    130                 135                 140                 


Thr Thr Ala Ser Pro Arg Thr Leu Thr Thr Glu Arg Asn Gly Ser Glu 
145                 150                 155                 160 


Thr Gln Thr Leu Val Thr Leu His Asn Asn Asn Gly Thr Lys Ile Ser 
                165                 170                 175     


Thr Trp Ala Asp Glu Ile Lys Asp Ser Gly Glu Thr Ile Arg Glu Pro 
            180                 185                 190         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        195                 200                 205             


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    210                 215                 220                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
225                 230                 235                 240 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                245                 250                 255     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            260                 265                 270         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        275                 280                 285             


Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro 
    290                 295                 300                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
305                 310                 315                 320 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr Lys Asn 
                325                 330                 335     


Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            340                 345                 350         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        355                 360                 365             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys 
    370                 375                 380                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
385                 390                 395                 400 


Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu 
                405                 410                 415     


Ser Leu Ser Pro Gly Lys 
            420         


<210>  35
<211>  594
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human CD113-hFcB

<400>  35

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ala Ser Pro Ile Ile Val Glu Pro His Val Thr Ala Val Trp 
            20                  25                  30          


Gly Lys Asn Val Ser Leu Lys Cys Leu Ile Glu Val Asn Glu Thr Ile 
        35                  40                  45              


Thr Gln Ile Ser Trp Glu Lys Ile His Gly Lys Ser Ser Gln Thr Val 
    50                  55                  60                  


Ala Val His His Pro Gln Tyr Gly Phe Ser Val Gln Gly Glu Tyr Gln 
65                  70                  75                  80  


Gly Arg Val Leu Phe Lys Asn Tyr Ser Leu Asn Asp Ala Thr Ile Thr 
                85                  90                  95      


Leu His Asn Ile Gly Phe Ser Asp Ser Gly Lys Tyr Ile Cys Lys Ala 
            100                 105                 110         


Val Thr Phe Pro Leu Gly Asn Ala Gln Ser Ser Thr Thr Val Thr Val 
        115                 120                 125             


Leu Val Glu Pro Thr Val Ser Leu Ile Lys Gly Pro Asp Ser Leu Ile 
    130                 135                 140                 


Asp Gly Gly Asn Glu Thr Val Ala Ala Ile Cys Ile Ala Ala Thr Gly 
145                 150                 155                 160 


Lys Pro Val Ala His Ile Asp Trp Glu Gly Asp Leu Gly Glu Met Glu 
                165                 170                 175     


Ser Thr Thr Thr Ser Phe Pro Asn Glu Thr Ala Thr Ile Ile Ser Gln 
            180                 185                 190         


Tyr Lys Leu Phe Pro Thr Arg Phe Ala Arg Gly Arg Arg Ile Thr Cys 
        195                 200                 205             


Val Val Lys His Pro Ala Leu Glu Lys Asp Ile Arg Tyr Ser Phe Ile 
    210                 215                 220                 


Leu Asp Ile Gln Tyr Ala Pro Glu Val Ser Val Thr Gly Tyr Asp Gly 
225                 230                 235                 240 


Asn Trp Phe Val Gly Arg Lys Gly Val Asn Leu Lys Cys Asn Ala Asp 
                245                 250                 255     


Ala Asn Pro Pro Pro Phe Lys Ser Val Trp Ser Arg Leu Asp Gly Gln 
            260                 265                 270         


Trp Pro Asp Gly Leu Leu Ala Ser Asp Asn Thr Leu His Phe Val His 
        275                 280                 285             


Pro Leu Thr Phe Asn Tyr Ser Gly Val Tyr Ile Cys Lys Val Thr Asn 
    290                 295                 300                 


Ser Leu Gly Gln Arg Ser Asp Gln Lys Val Ile Tyr Ile Ser Asp Pro 
305                 310                 315                 320 


Pro Thr Thr Thr Thr Leu Gln Pro Thr Ile Gln Trp His Pro Ser Thr 
                325                 330                 335     


Ala Asp Ile Glu Asp Leu Ala Thr Glu Pro Lys Lys Leu Pro Phe Pro 
            340                 345                 350         


Leu Ser Thr Leu Ala Thr Ile Lys Asp Asp Glu Pro Lys Ser Ser Asp 
        355                 360                 365             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    370                 375                 380                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
385                 390                 395                 400 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                405                 410                 415     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            420                 425                 430         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        435                 440                 445             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    450                 455                 460                 


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
465                 470                 475                 480 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                485                 490                 495     


Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr Lys Asn Gln Val Ser Leu 
            500                 505                 510         


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        515                 520                 525             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    530                 535                 540                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 
545                 550                 555                 560 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His 
                565                 570                 575     


Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            580                 585                 590         


Gly Lys 
        


<210>  36
<211>  252
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human FcB

<400>  36

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Ala Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Cys Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250         


<210>  37
<211>  71
<212>  PRT
<213>  Human gammaherpesvirus 8

<400>  37

Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Cys Leu Gly Tyr Gln 
1               5                   10                  15      


Lys Arg Pro Leu Pro Gln Val Leu Leu Ser Ser Trp Tyr Pro Thr Ser 
            20                  25                  30          


Gln Leu Cys Ser Lys Pro Gly Val Ile Phe Leu Thr Lys Arg Gly Arg 
        35                  40                  45              


Gln Val Cys Ala Asp Lys Ser Lys Asp Trp Val Lys Lys Leu Met Gln 
    50                  55                  60                  


Gln Leu Pro Val Thr Ala Arg 
65                  70      


<210>  38
<211>  21
<212>  PRT
<213>  Human gammaherpesvirus 8

<400>  38

Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Cys Leu Gly Tyr Gln 
1               5                   10                  15      


Lys Arg Pro Leu Pro 
            20      


<210>  39
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  V1delta

<400>  39

Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Ala Leu Gly Tyr Gln 
1               5                   10                  15      


Lys Arg Pro Leu Pro 
            20      


<210>  40
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  V1delta mut

<400>  40

Leu Gly Ala Ser Trp His Arg Pro Asp Ala Cys Ala Leu Gly Tyr Gln 
1               5                   10                  15      


Lys Arg Pro Leu Pro 
            20      


<210>  41
<211>  34
<212>  PRT
<213>  Human gammaherpesvirus 8

<400>  41

Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Cys Leu Gly Tyr Gln 
1               5                   10                  15      


Lys Arg Pro Leu Pro Gln Val Leu Leu Ser Ser Trp Tyr Pro Thr Ser 
            20                  25                  30          


Gln Leu 
        


<210>  42
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Vp1delta

<400>  42

Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Ala Leu Gly Tyr Gln 
1               5                   10                  15      


Lys Arg Pro Leu Pro Gln Val Leu Leu Ser Ser Trp Tyr Pro Thr Ser 
            20                  25                  30          


Gln Leu 
        


<210>  43
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Vp1delta mut

<400>  43

Leu Gly Ala Ser Trp His Arg Pro Asp Ala Cys Ala Leu Gly Tyr Gln 
1               5                   10                  15      


Lys Arg Pro Leu Pro Gln Val Leu Leu Ser Ser Trp Tyr Pro Thr Ser 
            20                  25                  30          


Gln Leu 
        


<210>  44
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgG1 Z3 domain

<400>  44

Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Asn Ser Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  45
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  exemplary sequence for component Z1 prime


<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa can be any naturally occurring amino acid

<400>  45

Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
1               5                   10                  15      


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            20                  25                  30          


Asp Tyr Phe Pro Glu Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
        35                  40                  45              


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
    50                  55                  60                  


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
65                  70                  75                  80  


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
                85                  90                  95      


Lys Lys Val Xaa 
            100 


<210>  46
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  exemplary purification tag

<400>  46

Ala Ser His His His His His His Met 
1               5                   


<210>  47
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  exemplary trimerization sequence

<400>  47

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Arg Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  48
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  exemplary sequence for component Z3 prime

<400>  48

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Cys 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  49
<211>  421
<212>  PRT
<213>  Artificial sequence

<220>
<223>  vMIPII-CH-hFcB


<220>
<221>  misc_feature
<222>  (189)..(189)
<223>  Xaa can be any naturally occurring amino acid

<400>  49

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Cys Leu Gly 
            20                  25                  30          


Tyr Gln Lys Arg Pro Leu Pro Gln Val Leu Leu Ser Ser Trp Tyr Pro 
        35                  40                  45              


Thr Ser Gln Leu Cys Ser Lys Pro Gly Val Ile Phe Leu Thr Lys Arg 
    50                  55                  60                  


Gly Arg Gln Val Cys Ala Asp Lys Ser Lys Asp Trp Val Lys Lys Leu 
65                  70                  75                  80  


Met Gln Gln Leu Pro Val Thr Ala Arg Ser Ser Ala Ser Thr Lys Gly 
                85                  90                  95      


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
            100                 105                 110         


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Val Thr 
        115                 120                 125             


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
    130                 135                 140                 


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
145                 150                 155                 160 


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
                165                 170                 175     


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Xaa Glu Pro Lys 
            180                 185                 190         


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
        195                 200                 205             


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    210                 215                 220                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
225                 230                 235                 240 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                245                 250                 255     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            260                 265                 270         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        275                 280                 285             


Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala 
    290                 295                 300                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
305                 310                 315                 320 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr Lys Asn Gln 
                325                 330                 335     


Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            340                 345                 350         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        355                 360                 365             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu 
    370                 375                 380                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
385                 390                 395                 400 


Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser 
                405                 410                 415     


Leu Ser Pro Gly Lys 
            420     


<210>  50
<211>  371
<212>  PRT
<213>  Artificial sequence

<220>
<223>  V1-CH- hFcB


<220>
<221>  misc_feature
<222>  (139)..(139)
<223>  Xaa can be any naturally occurring amino acid

<400>  50

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Cys Leu Gly 
            20                  25                  30          


Tyr Gln Lys Arg Pro Leu Pro Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        35                  40                  45              


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    50                  55                  60                  


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Val Thr Val Ser 
65                  70                  75                  80  


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                85                  90                  95      


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            100                 105                 110         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        115                 120                 125             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Xaa Glu Pro Lys Ser Ser 
    130                 135                 140                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
145                 150                 155                 160 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                165                 170                 175     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            180                 185                 190         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        195                 200                 205             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    210                 215                 220                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                245                 250                 255     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            260                 265                 270         


Tyr Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr Lys Asn Gln Val Ser 
        275                 280                 285             


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    290                 295                 300                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
305                 310                 315                 320 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                325                 330                 335     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu 
            340                 345                 350         


His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        355                 360                 365             


Pro Gly Lys 
    370     


<210>  51
<211>  371
<212>  PRT
<213>  Artificial sequence

<220>
<223>  V1delta-CH- hFcB


<220>
<221>  misc_feature
<222>  (139)..(139)
<223>  Xaa can be any naturally occurring amino acid

<400>  51

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Ala Leu Gly 
            20                  25                  30          


Tyr Gln Lys Arg Pro Leu Pro Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        35                  40                  45              


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    50                  55                  60                  


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Val Thr Val Ser 
65                  70                  75                  80  


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                85                  90                  95      


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            100                 105                 110         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        115                 120                 125             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Xaa Glu Pro Lys Ser Ser 
    130                 135                 140                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
145                 150                 155                 160 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                165                 170                 175     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            180                 185                 190         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        195                 200                 205             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    210                 215                 220                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                245                 250                 255     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            260                 265                 270         


Tyr Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr Lys Asn Gln Val Ser 
        275                 280                 285             


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    290                 295                 300                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
305                 310                 315                 320 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                325                 330                 335     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu 
            340                 345                 350         


His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        355                 360                 365             


Pro Gly Lys 
    370     


<210>  52
<211>  371
<212>  PRT
<213>  Artificial sequence

<220>
<223>  V1delta mut-CH- hFcB


<220>
<221>  misc_feature
<222>  (139)..(139)
<223>  Xaa can be any naturally occurring amino acid

<400>  52

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Gly Ala Ser Trp His Arg Pro Asp Ala Cys Ala Leu Gly 
            20                  25                  30          


Tyr Gln Lys Arg Pro Leu Pro Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        35                  40                  45              


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    50                  55                  60                  


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Val Thr Val Ser 
65                  70                  75                  80  


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                85                  90                  95      


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            100                 105                 110         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        115                 120                 125             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Xaa Glu Pro Lys Ser Ser 
    130                 135                 140                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
145                 150                 155                 160 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                165                 170                 175     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            180                 185                 190         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        195                 200                 205             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    210                 215                 220                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                245                 250                 255     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            260                 265                 270         


Tyr Thr Leu Pro Pro Ser Arg Cys Glu Leu Thr Lys Asn Gln Val Ser 
        275                 280                 285             


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    290                 295                 300                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
305                 310                 315                 320 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                325                 330                 335     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu 
            340                 345                 350         


His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        355                 360                 365             


Pro Gly Lys 
    370     


<210>  53
<211>  384
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Vp1-CH- hFcB


<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<400>  53

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Cys Leu Gly 
            20                  25                  30          


Tyr Gln Lys Arg Pro Leu Pro Gln Val Leu Leu Ser Ser Trp Tyr Pro 
        35                  40                  45              


Thr Ser Gln Leu Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    50                  55                  60                  


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
65                  70                  75                  80  


Cys Leu Val Lys Asp Tyr Phe Pro Glu Val Thr Val Ser Trp Asn Ser 
                85                  90                  95      


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            100                 105                 110         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        115                 120                 125             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    130                 135                 140                 


Thr Lys Val Asp Lys Lys Val Xaa Glu Pro Lys Ser Ser Asp Lys Thr 
145                 150                 155                 160 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                165                 170                 175     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            180                 185                 190         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        195                 200                 205             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    210                 215                 220                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
225                 230                 235                 240 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                245                 250                 255     


Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            260                 265                 270         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        275                 280                 285             


Pro Pro Ser Arg Cys Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
    290                 295                 300                 


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
305                 310                 315                 320 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                325                 330                 335     


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala 
        355                 360                 365             


Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380                 


<210>  54
<211>  384
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Vp1delta-CH- hFcB


<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<400>  54

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Ala Leu Gly 
            20                  25                  30          


Tyr Gln Lys Arg Pro Leu Pro Gln Val Leu Leu Ser Ser Trp Tyr Pro 
        35                  40                  45              


Thr Ser Gln Leu Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    50                  55                  60                  


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
65                  70                  75                  80  


Cys Leu Val Lys Asp Tyr Phe Pro Glu Val Thr Val Ser Trp Asn Ser 
                85                  90                  95      


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            100                 105                 110         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        115                 120                 125             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    130                 135                 140                 


Thr Lys Val Asp Lys Lys Val Xaa Glu Pro Lys Ser Ser Asp Lys Thr 
145                 150                 155                 160 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                165                 170                 175     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            180                 185                 190         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        195                 200                 205             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    210                 215                 220                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
225                 230                 235                 240 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                245                 250                 255     


Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            260                 265                 270         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        275                 280                 285             


Pro Pro Ser Arg Cys Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
    290                 295                 300                 


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
305                 310                 315                 320 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                325                 330                 335     


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala 
        355                 360                 365             


Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380                 


<210>  55
<211>  384
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Vp1delta mut-CH- hFcB


<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  Xaa can be any naturally occurring amino acid

<400>  55

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Gly Ala Ser Trp His Arg Pro Asp Ala Cys Ala Leu Gly 
            20                  25                  30          


Tyr Gln Lys Arg Pro Leu Pro Gln Val Leu Leu Ser Ser Trp Tyr Pro 
        35                  40                  45              


Thr Ser Gln Leu Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    50                  55                  60                  


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
65                  70                  75                  80  


Cys Leu Val Lys Asp Tyr Phe Pro Glu Val Thr Val Ser Trp Asn Ser 
                85                  90                  95      


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            100                 105                 110         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        115                 120                 125             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    130                 135                 140                 


Thr Lys Val Asp Lys Lys Val Xaa Glu Pro Lys Ser Ser Asp Lys Thr 
145                 150                 155                 160 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                165                 170                 175     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            180                 185                 190         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        195                 200                 205             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    210                 215                 220                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
225                 230                 235                 240 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                245                 250                 255     


Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            260                 265                 270         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        275                 280                 285             


Pro Pro Ser Arg Cys Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
    290                 295                 300                 


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
305                 310                 315                 320 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                325                 330                 335     


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala 
        355                 360                 365             


Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380                 


<210>  56
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  exemplary trimerization domain

<400>  56

Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu Asn Lys 
1               5                   10                  15      


Glu Leu Ala Asn Glu Leu Arg Arg 
            20                  


<210>  57
<211>  197
<212>  PRT
<213>  Artificial sequence

<220>
<223>  vMIPII-CL prime

<400>  57

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Cys Leu Gly 
            20                  25                  30          


Tyr Gln Lys Arg Pro Leu Pro Gln Val Leu Leu Ser Ser Trp Tyr Pro 
        35                  40                  45              


Thr Ser Gln Leu Cys Ser Lys Pro Gly Val Ile Phe Leu Thr Lys Arg 
    50                  55                  60                  


Gly Arg Gln Val Cys Ala Asp Lys Ser Lys Asp Trp Val Lys Lys Leu 
65                  70                  75                  80  


Met Gln Gln Leu Pro Val Thr Ala Arg Lys Arg Thr Val Ala Ala Pro 
                85                  90                  95      


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
            100                 105                 110         


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
        115                 120                 125             


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
    130                 135                 140                 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
145                 150                 155                 160 


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
                165                 170                 175     


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
            180                 185                 190         


Asn Arg Gly Glu Cys 
        195         


<210>  58
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  V1-CL prime

<400>  58

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Cys Leu Gly 
            20                  25                  30          


Tyr Gln Lys Arg Pro Leu Pro Lys Arg Thr Val Ala Ala Pro Ser Val 
        35                  40                  45              


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
    50                  55                  60                  


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
65                  70                  75                  80  


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
                85                  90                  95      


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
            100                 105                 110         


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
        115                 120                 125             


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
    130                 135                 140                 


Gly Glu Cys 
145         


<210>  59
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  V1dleta-CL prime

<400>  59

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Ala Leu Gly 
            20                  25                  30          


Tyr Gln Lys Arg Pro Leu Pro Lys Arg Thr Val Ala Ala Pro Ser Val 
        35                  40                  45              


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
    50                  55                  60                  


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
65                  70                  75                  80  


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
                85                  90                  95      


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
            100                 105                 110         


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
        115                 120                 125             


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
    130                 135                 140                 


Gly Glu Cys 
145         


<210>  60
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  V1delta mut-CL prime

<400>  60

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Gly Ala Ser Trp His Arg Pro Asp Ala Cys Ala Leu Gly 
            20                  25                  30          


Tyr Gln Lys Arg Pro Leu Pro Lys Arg Thr Val Ala Ala Pro Ser Val 
        35                  40                  45              


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
    50                  55                  60                  


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
65                  70                  75                  80  


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
                85                  90                  95      


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
            100                 105                 110         


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
        115                 120                 125             


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
    130                 135                 140                 


Gly Glu Cys 
145         


<210>  61
<211>  160
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Vp1-CL prime

<400>  61

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Cys Leu Gly 
            20                  25                  30          


Tyr Gln Lys Arg Pro Leu Pro Gln Val Leu Leu Ser Ser Trp Tyr Pro 
        35                  40                  45              


Thr Ser Gln Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    50                  55                  60                  


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
65                  70                  75                  80  


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                85                  90                  95      


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            100                 105                 110         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        115                 120                 125             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    130                 135                 140                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
145                 150                 155                 160 


<210>  62
<211>  160
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Vp1delta-CL prime

<400>  62

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Gly Ala Ser Trp His Arg Pro Asp Lys Cys Ala Leu Gly 
            20                  25                  30          


Tyr Gln Lys Arg Pro Leu Pro Gln Val Leu Leu Ser Ser Trp Tyr Pro 
        35                  40                  45              


Thr Ser Gln Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    50                  55                  60                  


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
65                  70                  75                  80  


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                85                  90                  95      


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            100                 105                 110         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        115                 120                 125             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    130                 135                 140                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
145                 150                 155                 160 


<210>  63
<211>  160
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Vp1delta mut-CL prime

<400>  63

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Leu Gly Ala Ser Trp His Arg Pro Asp Ala Cys Ala Leu Gly 
            20                  25                  30          


Tyr Gln Lys Arg Pro Leu Pro Gln Val Leu Leu Ser Ser Trp Tyr Pro 
        35                  40                  45              


Thr Ser Gln Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    50                  55                  60                  


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
65                  70                  75                  80  


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                85                  90                  95      


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            100                 105                 110         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        115                 120                 125             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    130                 135                 140                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
145                 150                 155                 160 


<210>  64
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  exemplary sequence for component CL prime or component CL

<400>  64

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
1               5                   10                  15      


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
            20                  25                  30          


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
        35                  40                  45              


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
    50                  55                  60                  


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
65                  70                  75                  80  


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
                85                  90                  95      


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105             


<210>  65
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  65

Gly Gly Gly Gly Ser 
1               5   


<210>  66
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  66

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  67
<211>  98
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgG1 Z1 domain

<400>  67

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val 
        


<210>  68
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgG1 hinge region

<400>  68

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  69
<211>  103
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgG1 Z2 domain

<400>  69

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
1               5                   10                  15      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            20                  25                  30          


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        35                  40                  45              


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    50                  55                  60                  


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
65                  70                  75                  80  


Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                85                  90                  95      


Lys Thr Ile Ser Lys Ala Lys 
            100             


