                         SEQUENCE LISTING

<110>  Integrated DNA Technologies, Inc.
 
<120>  CAS12a MUTANT GENES AND POLYPEPTIDES ENCODED BY SAME

<130>  PA2019-1

<150>  US 62/789,571
<151>  2019-01-08

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  3918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  1
acccagttcg agggcttcac caacctgtac caggtgtcca agaccctgag attcgagctg       60

atcccccagg gcaagacact gaagcacatc caggaacagg gcttcatcga agaggacaag      120

gcccggaacg accactacaa agagctgaag cccatcatcg accggatcta caagacctac      180

gccgaccagt gcctgcagct ggtgcagctg gactgggaga atctgagcgc cgccatcgac      240

agctaccgga aagagaaaac cgaggaaacc cggaacgccc tgatcgagga acaggccacc      300

tacagaaacg ccatccacga ctacttcatc ggccggaccg acaacctgac cgacgccatc      360

aacaagcggc acgccgagat ctataagggc ctgttcaagg ccgagctgtt caacggcaag      420

gtgctgaagc agctgggcac cgtgaccacc accgagcacg aaaacgccct gctgcggagc      480

ttcgacaagt tcaccaccta cttcagcggc ttctacgaga accggaagaa cgtgttcagc      540

gccgaggaca tcagcaccgc catcccccac agaatcgtgc aggacaactt ccccaagttc      600

aaagagaact gccacatctt cacccggctg atcaccgccg tgcccagcct gagagaacac      660

ttcgagaacg tgaagaaggc catcggcatc ttcgtgtcca ccagcatcga ggaagtgttc      720

agcttcccat tctacaacca gctgctgacc cagacccaga tcgacctgta taatcagctg      780

ctgggcggca tcagcagaga ggccggcacc gagaagatca agggcctgaa cgaagtgctg      840

aacctggcca tccagaagaa cgacgagaca gcccacatca ttgccagcct gccccaccgg      900

ttcatccctc tgttcaagca gatcctgagc gacagaaaca ccctgagctt catcctggaa      960

gagttcaagt ccgatgagga agtgatccag agcttctgca agtataagac cctgctgagg     1020

aacgagaatg tgctggaaac cgccgaggcc ctgttcaatg agctgaacag catcgacctg     1080

acccacatct ttatcagcca caagaagctg gaaacaatca gcagcgccct gtgcgaccac     1140

tgggacacac tgcggaatgc cctgtacgag cggcggatct ctgagctgac cggcaagatc     1200

accaagagcg ccaaagaaaa ggtgcagcgg agcctgaagc acgaggatat caacctgcag     1260

gaaatcatca gcgccgctgg caaagaactg agcgaggcct ttaagcagaa aaccagcgag     1320

atcctgtccc acgcccacgc cgcactggat cagcctctgc ctaccaccct gaagaagcag     1380

gaagagaaag agatcctgaa gtcccagctg gacagcctgc tgggcctgta ccatctgctg     1440

gattggttcg ccgtggacga gagcaacgag gtggaccccg agttctccgc cagactgaca     1500

ggcatcaaac tggaaatgga acccagcctg tccttctaca acaaggccag aaactacgcc     1560

accaagaaac cctacagcgt ggaaaagttt aagctgaact tccagatgcc caccctggcc     1620

agcggctggg acgtgaacaa agagaagaac aacggcgcca tcctgttcgt gaagaacgga     1680

ctgtactacc tgggcatcat gcctaagcag aagggcagat acaaggccct gtcctttgag     1740

cccaccgaaa agaccagcga gggctttgac aagatgtact acgattactt ccccgacgcc     1800

gccaagatga tccccaagtg cagcacccag ctgaaggccg tgaccgccca ctttcagacc     1860

cacaccaccc ccatcctgct gagcaacaac ttcatcgagc ccctggaaat caccaaagag     1920

atctacgacc tgaacaaccc cgagaaagag cccaagaagt tccagaccgc ctacgccaag     1980

aaaaccggcg accagaaggg ctaccgcgag gctctgtgca agtggatcga ctttacccgg     2040

gacttcctga gcaagtacac caagaccacc tccatcgatc tgagcagcct gcggcccagc     2100

tcccagtaca aggatctggg cgagtactac gccgagctga accctctgct gtaccacatc     2160

agcttccagc ggatcgccga aaaagaaatc atggacgccg tggaaaccgg caagctgtac     2220

ctgttccaga tctataacaa ggacttcgcc aagggccacc acggcaagcc caatctgcac     2280

accctgtact ggaccggcct gtttagcccc gagaatctgg ccaagaccag catcaagctg     2340

aacggccagg ccgaactgtt ttaccggccc aagagccgga tgaagcggat ggcccataga     2400

ctgggcgaga agatgctgaa caagaaactg aaggaccaga aaacccctat ccccgacaca     2460

ctgtatcagg aactgtacga ctacgtgaac caccggctga gccacgacct gtccgacgaa     2520

gctagagcac tgctgcccaa cgtgatcaca aaagaggtgt cccacgagat catcaaggac     2580

cggcggttta cctccgataa gttcttcttc cacgtgccca tcaccctgaa ctaccaggcc     2640

gccaacagcc ccagcaagtt caaccagaga gtgaacgcct acctgaaaga gcaccccgag     2700

acacccatca ttggcatcga cagaggcgag cggaacctga tctacatcac cgtgatcgac     2760

agcacaggca aaatcctgga acagagaagc ctgaacacca tccagcagtt cgactaccag     2820

aagaaactgg acaaccggga aaaagaacgg gtggccgcca gacaggcttg gagcgtcgtg     2880

ggcaccatta aggacctgaa gcagggctac ctgagccaag tgattcacga gatcgtggac     2940

ctgatgatcc actatcaggc tgtggtggtg ctggaaaacc tgaacttcgg cttcaagagc     3000

aagcggaccg gaatcgccga gaaagccgtg taccagcagt ttgagaaaat gctgatcgac     3060

aagctgaatt gcctggtgct gaaagactac cccgctgaga aagtgggagg cgtgctgaat     3120

ccctaccagc tgaccgacca gttcacctcc tttgccaaga tgggaaccca gagcggcttc     3180

ctgttctacg tgccagcccc ctacaccagc aagatcgacc ctctgaccgg cttcgtggac     3240

cccttcgtgt ggaaaaccat caagaaccac gagtcccgga agcacttcct ggaaggcttt     3300

gacttcctgc actacgacgt gaaaacaggc gatttcatcc tgcacttcaa gatgaatcgg     3360

aatctgtcct tccagagggg cctgcccggc ttcatgcctg cctgggatat cgtgttcgag     3420

aagaatgaga cacagttcga cgccaaggga acccccttta tcgccggcaa gaggatcgtg     3480

cctgtgatcg agaaccacag attcaccggc agataccggg acctgtaccc cgccaacgag     3540

ctgattgccc tgctggaaga gaagggcatc gtgttccggg acggcagcaa catcctgccc     3600

aagctgctgg aaaatgacga cagccacgcc atcgatacca tggtggcact gatccgcagc     3660

gtgctgcaga tgcggaacag caatgccgcc accggcgagg actacatcaa tagcccagtg     3720

cgggacctga acggcgtgtg cttcgacagc agattccaga accccgagtg gcccatggat     3780

gccgacgcca atggcgccta ccacattgcc ctgaagggac agctgctgct gaaccatctg     3840

aaagagagca aagacctgaa actgcagaac ggcatctcca accaggactg gctggcctat     3900

atccaggaac tgcggaac                                                   3918


<210>  2
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  3
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Ser Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  4
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Ser His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  5
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Ser Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  6
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Ser Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  7
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Ser 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  8
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Ser Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  9
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Ser  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  10
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Ser 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  11
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Ser His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Ser Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Ser Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Ser 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  12
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Ser Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Ser His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Ser Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Ser Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Ser Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Ser 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  13
<211>  3921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
atgacccagt tcgagggctt caccaacctg taccaggtgt ccaagaccct gagattcgag       60

ctgatccccc agggcaagac actgaagcac atccaggaac agggcttcat cgaagaggac      120

aaggcccgga acgaccacta caaagagctg aagcccatca tcgaccggat ctacaagacc      180

tacgccgacc agtctctgca gctggtgcag ctggactggg agaatctgag cgccgccatc      240

gacagctacc ggaaagagaa aaccgaggaa acccggaacg ccctgatcga ggaacaggcc      300

acctacagaa acgccatcca cgactacttc atcggccgga ccgacaacct gaccgacgcc      360

atcaacaagc ggcacgccga gatctataag ggcctgttca aggccgagct gttcaacggc      420

aaggtgctga agcagctggg caccgtgacc accaccgagc acgaaaacgc cctgctgcgg      480

agcttcgaca agttcaccac ctacttcagc ggcttctacg agaaccggaa gaacgtgttc      540

agcgccgagg acatcagcac cgccatcccc cacagaatcg tgcaggacaa cttccccaag      600

ttcaaagaga actgccacat cttcacccgg ctgatcaccg ccgtgcccag cctgagagaa      660

cacttcgaga acgtgaagaa ggccatcggc atcttcgtgt ccaccagcat cgaggaagtg      720

ttcagcttcc cattctacaa ccagctgctg acccagaccc agatcgacct gtataatcag      780

ctgctgggcg gcatcagcag agaggccggc accgagaaga tcaagggcct gaacgaagtg      840

ctgaacctgg ccatccagaa gaacgacgag acagcccaca tcattgccag cctgccccac      900

cggttcatcc ctctgttcaa gcagatcctg agcgacagaa acaccctgag cttcatcctg      960

gaagagttca agtccgatga ggaagtgatc cagagcttct gcaagtataa gaccctgctg     1020

aggaacgaga atgtgctgga aaccgccgag gccctgttca atgagctgaa cagcatcgac     1080

ctgacccaca tctttatcag ccacaagaag ctggaaacaa tcagcagcgc cctgtgcgac     1140

cactgggaca cactgcggaa tgccctgtac gagcggcgga tctctgagct gaccggcaag     1200

atcaccaaga gcgccaaaga aaaggtgcag cggagcctga agcacgagga tatcaacctg     1260

caggaaatca tcagcgccgc tggcaaagaa ctgagcgagg cctttaagca gaaaaccagc     1320

gagatcctgt cccacgccca cgccgcactg gatcagcctc tgcctaccac cctgaagaag     1380

caggaagaga aagagatcct gaagtcccag ctggacagcc tgctgggcct gtaccatctg     1440

ctggattggt tcgccgtgga cgagagcaac gaggtggacc ccgagttctc cgccagactg     1500

acaggcatca aactggaaat ggaacccagc ctgtccttct acaacaaggc cagaaactac     1560

gccaccaaga aaccctacag cgtggaaaag tttaagctga acttccagat gcccaccctg     1620

gccagcggct gggacgtgaa caaagagaag aacaacggcg ccatcctgtt cgtgaagaac     1680

ggactgtact acctgggcat catgcctaag cagaagggca gatacaaggc cctgtccttt     1740

gagcccaccg aaaagaccag cgagggcttt gacaagatgt actacgatta cttccccgac     1800

gccgccaaga tgatccccaa gtgcagcacc cagctgaagg ccgtgaccgc ccactttcag     1860

acccacacca cccccatcct gctgagcaac aacttcatcg agcccctgga aatcaccaaa     1920

gagatctacg acctgaacaa ccccgagaaa gagcccaaga agttccagac cgcctacgcc     1980

aagaaaaccg gcgaccagaa gggctaccgc gaggctctgt gcaagtggat cgactttacc     2040

cgggacttcc tgagcaagta caccaagacc acctccatcg atctgagcag cctgcggccc     2100

agctcccagt acaaggatct gggcgagtac tacgccgagc tgaaccctct gctgtaccac     2160

atcagcttcc agcggatcgc cgaaaaagaa atcatggacg ccgtggaaac cggcaagctg     2220

tacctgttcc agatctataa caaggacttc gccaagggcc accacggcaa gcccaatctg     2280

cacaccctgt actggaccgg cctgtttagc cccgagaatc tggccaagac cagcatcaag     2340

ctgaacggcc aggccgaact gttttaccgg cccaagagcc ggatgaagcg gatggcccat     2400

agactgggcg agaagatgct gaacaagaaa ctgaaggacc agaaaacccc tatccccgac     2460

acactgtatc aggaactgta cgactacgtg aaccaccggc tgagccacga cctgtccgac     2520

gaagctagag cactgctgcc caacgtgatc acaaaagagg tgtcccacga gatcatcaag     2580

gaccggcggt ttacctccga taagttcttc ttccacgtgc ccatcaccct gaactaccag     2640

gccgccaaca gccccagcaa gttcaaccag agagtgaacg cctacctgaa agagcacccc     2700

gagacaccca tcattggcat cgacagaggc gagcggaacc tgatctacat caccgtgatc     2760

gacagcacag gcaaaatcct ggaacagaga agcctgaaca ccatccagca gttcgactac     2820

cagaagaaac tggacaaccg ggaaaaagaa cgggtggccg ccagacaggc ttggagcgtc     2880

gtgggcacca ttaaggacct gaagcagggc tacctgagcc aagtgattca cgagatcgtg     2940

gacctgatga tccactatca ggctgtggtg gtgctggaaa acctgaactt cggcttcaag     3000

agcaagcgga ccggaatcgc cgagaaagcc gtgtaccagc agtttgagaa aatgctgatc     3060

gacaagctga attgcctggt gctgaaagac taccccgctg agaaagtggg aggcgtgctg     3120

aatccctacc agctgaccga ccagttcacc tcctttgcca agatgggaac ccagagcggc     3180

ttcctgttct acgtgccagc cccctacacc agcaagatcg accctctgac cggcttcgtg     3240

gaccccttcg tgtggaaaac catcaagaac cacgagtccc ggaagcactt cctggaaggc     3300

tttgacttcc tgcactacga cgtgaaaaca ggcgatttca tcctgcactt caagatgaat     3360

cggaatctgt ccttccagag gggcctgccc ggcttcatgc ctgcctggga tatcgtgttc     3420

gagaagaatg agacacagtt cgacgccaag ggaaccccct ttatcgccgg caagaggatc     3480

gtgcctgtga tcgagaacca cagattcacc ggcagatacc gggacctgta ccccgccaac     3540

gagctgattg ccctgctgga agagaagggc atcgtgttcc gggacggcag caacatcctg     3600

cccaagctgc tggaaaatga cgacagccac gccatcgata ccatggtggc actgatccgc     3660

agcgtgctgc agatgcggaa cagcaatgcc gccaccggcg aggactacat caatagccca     3720

gtgcgggacc tgaacggcgt gtgcttcgac agcagattcc agaaccccga gtggcccatg     3780

gatgccgacg ccaatggcgc ctaccacatt gccctgaagg gacagctgct gctgaaccat     3840

ctgaaagaga gcaaagacct gaaactgcag aacggcatct ccaaccagga ctggctggcc     3900

tatatccagg aactgcggaa c                                               3921


<210>  14
<211>  3921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
atgacccagt tcgagggctt caccaacctg taccaggtgt ccaagaccct gagattcgag       60

ctgatccccc agggcaagac actgaagcac atccaggaac agggcttcat cgaagaggac      120

aaggcccgga acgaccacta caaagagctg aagcccatca tcgaccggat ctacaagacc      180

tacgccgacc agtgcctgca gctggtgcag ctggactggg agaatctgag cgccgccatc      240

gacagctacc ggaaagagaa aaccgaggaa acccggaacg ccctgatcga ggaacaggcc      300

acctacagaa acgccatcca cgactacttc atcggccgga ccgacaacct gaccgacgcc      360

atcaacaagc ggcacgccga gatctataag ggcctgttca aggccgagct gttcaacggc      420

aaggtgctga agcagctggg caccgtgacc accaccgagc acgaaaacgc cctgctgcgg      480

agcttcgaca agttcaccac ctacttcagc ggcttctacg agaaccggaa gaacgtgttc      540

agcgccgagg acatcagcac cgccatcccc cacagaatcg tgcaggacaa cttccccaag      600

ttcaaagaga actctcacat cttcacccgg ctgatcaccg ccgtgcccag cctgagagaa      660

cacttcgaga acgtgaagaa ggccatcggc atcttcgtgt ccaccagcat cgaggaagtg      720

ttcagcttcc cattctacaa ccagctgctg acccagaccc agatcgacct gtataatcag      780

ctgctgggcg gcatcagcag agaggccggc accgagaaga tcaagggcct gaacgaagtg      840

ctgaacctgg ccatccagaa gaacgacgag acagcccaca tcattgccag cctgccccac      900

cggttcatcc ctctgttcaa gcagatcctg agcgacagaa acaccctgag cttcatcctg      960

gaagagttca agtccgatga ggaagtgatc cagagcttct gcaagtataa gaccctgctg     1020

aggaacgaga atgtgctgga aaccgccgag gccctgttca atgagctgaa cagcatcgac     1080

ctgacccaca tctttatcag ccacaagaag ctggaaacaa tcagcagcgc cctgtgcgac     1140

cactgggaca cactgcggaa tgccctgtac gagcggcgga tctctgagct gaccggcaag     1200

atcaccaaga gcgccaaaga aaaggtgcag cggagcctga agcacgagga tatcaacctg     1260

caggaaatca tcagcgccgc tggcaaagaa ctgagcgagg cctttaagca gaaaaccagc     1320

gagatcctgt cccacgccca cgccgcactg gatcagcctc tgcctaccac cctgaagaag     1380

caggaagaga aagagatcct gaagtcccag ctggacagcc tgctgggcct gtaccatctg     1440

ctggattggt tcgccgtgga cgagagcaac gaggtggacc ccgagttctc cgccagactg     1500

acaggcatca aactggaaat ggaacccagc ctgtccttct acaacaaggc cagaaactac     1560

gccaccaaga aaccctacag cgtggaaaag tttaagctga acttccagat gcccaccctg     1620

gccagcggct gggacgtgaa caaagagaag aacaacggcg ccatcctgtt cgtgaagaac     1680

ggactgtact acctgggcat catgcctaag cagaagggca gatacaaggc cctgtccttt     1740

gagcccaccg aaaagaccag cgagggcttt gacaagatgt actacgatta cttccccgac     1800

gccgccaaga tgatccccaa gtgcagcacc cagctgaagg ccgtgaccgc ccactttcag     1860

acccacacca cccccatcct gctgagcaac aacttcatcg agcccctgga aatcaccaaa     1920

gagatctacg acctgaacaa ccccgagaaa gagcccaaga agttccagac cgcctacgcc     1980

aagaaaaccg gcgaccagaa gggctaccgc gaggctctgt gcaagtggat cgactttacc     2040

cgggacttcc tgagcaagta caccaagacc acctccatcg atctgagcag cctgcggccc     2100

agctcccagt acaaggatct gggcgagtac tacgccgagc tgaaccctct gctgtaccac     2160

atcagcttcc agcggatcgc cgaaaaagaa atcatggacg ccgtggaaac cggcaagctg     2220

tacctgttcc agatctataa caaggacttc gccaagggcc accacggcaa gcccaatctg     2280

cacaccctgt actggaccgg cctgtttagc cccgagaatc tggccaagac cagcatcaag     2340

ctgaacggcc aggccgaact gttttaccgg cccaagagcc ggatgaagcg gatggcccat     2400

agactgggcg agaagatgct gaacaagaaa ctgaaggacc agaaaacccc tatccccgac     2460

acactgtatc aggaactgta cgactacgtg aaccaccggc tgagccacga cctgtccgac     2520

gaagctagag cactgctgcc caacgtgatc acaaaagagg tgtcccacga gatcatcaag     2580

gaccggcggt ttacctccga taagttcttc ttccacgtgc ccatcaccct gaactaccag     2640

gccgccaaca gccccagcaa gttcaaccag agagtgaacg cctacctgaa agagcacccc     2700

gagacaccca tcattggcat cgacagaggc gagcggaacc tgatctacat caccgtgatc     2760

gacagcacag gcaaaatcct ggaacagaga agcctgaaca ccatccagca gttcgactac     2820

cagaagaaac tggacaaccg ggaaaaagaa cgggtggccg ccagacaggc ttggagcgtc     2880

gtgggcacca ttaaggacct gaagcagggc tacctgagcc aagtgattca cgagatcgtg     2940

gacctgatga tccactatca ggctgtggtg gtgctggaaa acctgaactt cggcttcaag     3000

agcaagcgga ccggaatcgc cgagaaagcc gtgtaccagc agtttgagaa aatgctgatc     3060

gacaagctga attgcctggt gctgaaagac taccccgctg agaaagtggg aggcgtgctg     3120

aatccctacc agctgaccga ccagttcacc tcctttgcca agatgggaac ccagagcggc     3180

ttcctgttct acgtgccagc cccctacacc agcaagatcg accctctgac cggcttcgtg     3240

gaccccttcg tgtggaaaac catcaagaac cacgagtccc ggaagcactt cctggaaggc     3300

tttgacttcc tgcactacga cgtgaaaaca ggcgatttca tcctgcactt caagatgaat     3360

cggaatctgt ccttccagag gggcctgccc ggcttcatgc ctgcctggga tatcgtgttc     3420

gagaagaatg agacacagtt cgacgccaag ggaaccccct ttatcgccgg caagaggatc     3480

gtgcctgtga tcgagaacca cagattcacc ggcagatacc gggacctgta ccccgccaac     3540

gagctgattg ccctgctgga agagaagggc atcgtgttcc gggacggcag caacatcctg     3600

cccaagctgc tggaaaatga cgacagccac gccatcgata ccatggtggc actgatccgc     3660

agcgtgctgc agatgcggaa cagcaatgcc gccaccggcg aggactacat caatagccca     3720

gtgcgggacc tgaacggcgt gtgcttcgac agcagattcc agaaccccga gtggcccatg     3780

gatgccgacg ccaatggcgc ctaccacatt gccctgaagg gacagctgct gctgaaccat     3840

ctgaaagaga gcaaagacct gaaactgcag aacggcatct ccaaccagga ctggctggcc     3900

tatatccagg aactgcggaa c                                               3921


<210>  15
<211>  3921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  15
atgacccagt tcgagggctt caccaacctg taccaggtgt ccaagaccct gagattcgag       60

ctgatccccc agggcaagac actgaagcac atccaggaac agggcttcat cgaagaggac      120

aaggcccgga acgaccacta caaagagctg aagcccatca tcgaccggat ctacaagacc      180

tacgccgacc agtgcctgca gctggtgcag ctggactggg agaatctgag cgccgccatc      240

gacagctacc ggaaagagaa aaccgaggaa acccggaacg ccctgatcga ggaacaggcc      300

acctacagaa acgccatcca cgactacttc atcggccgga ccgacaacct gaccgacgcc      360

atcaacaagc ggcacgccga gatctataag ggcctgttca aggccgagct gttcaacggc      420

aaggtgctga agcagctggg caccgtgacc accaccgagc acgaaaacgc cctgctgcgg      480

agcttcgaca agttcaccac ctacttcagc ggcttctacg agaaccggaa gaacgtgttc      540

agcgccgagg acatcagcac cgccatcccc cacagaatcg tgcaggacaa cttccccaag      600

ttcaaagaga actgccacat cttcacccgg ctgatcaccg ccgtgcccag cctgagagaa      660

cacttcgaga acgtgaagaa ggccatcggc atcttcgtgt ccaccagcat cgaggaagtg      720

ttcagcttcc cattctacaa ccagctgctg acccagaccc agatcgacct gtataatcag      780

ctgctgggcg gcatcagcag agaggccggc accgagaaga tcaagggcct gaacgaagtg      840

ctgaacctgg ccatccagaa gaacgacgag acagcccaca tcattgccag cctgccccac      900

cggttcatcc ctctgttcaa gcagatcctg agcgacagaa acaccctgag cttcatcctg      960

gaagagttca agtccgatga ggaagtgatc cagagcttct ctaagtataa gaccctgctg     1020

aggaacgaga atgtgctgga aaccgccgag gccctgttca atgagctgaa cagcatcgac     1080

ctgacccaca tctttatcag ccacaagaag ctggaaacaa tcagcagcgc cctgtgcgac     1140

cactgggaca cactgcggaa tgccctgtac gagcggcgga tctctgagct gaccggcaag     1200

atcaccaaga gcgccaaaga aaaggtgcag cggagcctga agcacgagga tatcaacctg     1260

caggaaatca tcagcgccgc tggcaaagaa ctgagcgagg cctttaagca gaaaaccagc     1320

gagatcctgt cccacgccca cgccgcactg gatcagcctc tgcctaccac cctgaagaag     1380

caggaagaga aagagatcct gaagtcccag ctggacagcc tgctgggcct gtaccatctg     1440

ctggattggt tcgccgtgga cgagagcaac gaggtggacc ccgagttctc cgccagactg     1500

acaggcatca aactggaaat ggaacccagc ctgtccttct acaacaaggc cagaaactac     1560

gccaccaaga aaccctacag cgtggaaaag tttaagctga acttccagat gcccaccctg     1620

gccagcggct gggacgtgaa caaagagaag aacaacggcg ccatcctgtt cgtgaagaac     1680

ggactgtact acctgggcat catgcctaag cagaagggca gatacaaggc cctgtccttt     1740

gagcccaccg aaaagaccag cgagggcttt gacaagatgt actacgatta cttccccgac     1800

gccgccaaga tgatccccaa gtgcagcacc cagctgaagg ccgtgaccgc ccactttcag     1860

acccacacca cccccatcct gctgagcaac aacttcatcg agcccctgga aatcaccaaa     1920

gagatctacg acctgaacaa ccccgagaaa gagcccaaga agttccagac cgcctacgcc     1980

aagaaaaccg gcgaccagaa gggctaccgc gaggctctgt gcaagtggat cgactttacc     2040

cgggacttcc tgagcaagta caccaagacc acctccatcg atctgagcag cctgcggccc     2100

agctcccagt acaaggatct gggcgagtac tacgccgagc tgaaccctct gctgtaccac     2160

atcagcttcc agcggatcgc cgaaaaagaa atcatggacg ccgtggaaac cggcaagctg     2220

tacctgttcc agatctataa caaggacttc gccaagggcc accacggcaa gcccaatctg     2280

cacaccctgt actggaccgg cctgtttagc cccgagaatc tggccaagac cagcatcaag     2340

ctgaacggcc aggccgaact gttttaccgg cccaagagcc ggatgaagcg gatggcccat     2400

agactgggcg agaagatgct gaacaagaaa ctgaaggacc agaaaacccc tatccccgac     2460

acactgtatc aggaactgta cgactacgtg aaccaccggc tgagccacga cctgtccgac     2520

gaagctagag cactgctgcc caacgtgatc acaaaagagg tgtcccacga gatcatcaag     2580

gaccggcggt ttacctccga taagttcttc ttccacgtgc ccatcaccct gaactaccag     2640

gccgccaaca gccccagcaa gttcaaccag agagtgaacg cctacctgaa agagcacccc     2700

gagacaccca tcattggcat cgacagaggc gagcggaacc tgatctacat caccgtgatc     2760

gacagcacag gcaaaatcct ggaacagaga agcctgaaca ccatccagca gttcgactac     2820

cagaagaaac tggacaaccg ggaaaaagaa cgggtggccg ccagacaggc ttggagcgtc     2880

gtgggcacca ttaaggacct gaagcagggc tacctgagcc aagtgattca cgagatcgtg     2940

gacctgatga tccactatca ggctgtggtg gtgctggaaa acctgaactt cggcttcaag     3000

agcaagcgga ccggaatcgc cgagaaagcc gtgtaccagc agtttgagaa aatgctgatc     3060

gacaagctga attgcctggt gctgaaagac taccccgctg agaaagtggg aggcgtgctg     3120

aatccctacc agctgaccga ccagttcacc tcctttgcca agatgggaac ccagagcggc     3180

ttcctgttct acgtgccagc cccctacacc agcaagatcg accctctgac cggcttcgtg     3240

gaccccttcg tgtggaaaac catcaagaac cacgagtccc ggaagcactt cctggaaggc     3300

tttgacttcc tgcactacga cgtgaaaaca ggcgatttca tcctgcactt caagatgaat     3360

cggaatctgt ccttccagag gggcctgccc ggcttcatgc ctgcctggga tatcgtgttc     3420

gagaagaatg agacacagtt cgacgccaag ggaaccccct ttatcgccgg caagaggatc     3480

gtgcctgtga tcgagaacca cagattcacc ggcagatacc gggacctgta ccccgccaac     3540

gagctgattg ccctgctgga agagaagggc atcgtgttcc gggacggcag caacatcctg     3600

cccaagctgc tggaaaatga cgacagccac gccatcgata ccatggtggc actgatccgc     3660

agcgtgctgc agatgcggaa cagcaatgcc gccaccggcg aggactacat caatagccca     3720

gtgcgggacc tgaacggcgt gtgcttcgac agcagattcc agaaccccga gtggcccatg     3780

gatgccgacg ccaatggcgc ctaccacatt gccctgaagg gacagctgct gctgaaccat     3840

ctgaaagaga gcaaagacct gaaactgcag aacggcatct ccaaccagga ctggctggcc     3900

tatatccagg aactgcggaa c                                               3921


<210>  16
<211>  3921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
atgacccagt tcgagggctt caccaacctg taccaggtgt ccaagaccct gagattcgag       60

ctgatccccc agggcaagac actgaagcac atccaggaac agggcttcat cgaagaggac      120

aaggcccgga acgaccacta caaagagctg aagcccatca tcgaccggat ctacaagacc      180

tacgccgacc agtgcctgca gctggtgcag ctggactggg agaatctgag cgccgccatc      240

gacagctacc ggaaagagaa aaccgaggaa acccggaacg ccctgatcga ggaacaggcc      300

acctacagaa acgccatcca cgactacttc atcggccgga ccgacaacct gaccgacgcc      360

atcaacaagc ggcacgccga gatctataag ggcctgttca aggccgagct gttcaacggc      420

aaggtgctga agcagctggg caccgtgacc accaccgagc acgaaaacgc cctgctgcgg      480

agcttcgaca agttcaccac ctacttcagc ggcttctacg agaaccggaa gaacgtgttc      540

agcgccgagg acatcagcac cgccatcccc cacagaatcg tgcaggacaa cttccccaag      600

ttcaaagaga actgccacat cttcacccgg ctgatcaccg ccgtgcccag cctgagagaa      660

cacttcgaga acgtgaagaa ggccatcggc atcttcgtgt ccaccagcat cgaggaagtg      720

ttcagcttcc cattctacaa ccagctgctg acccagaccc agatcgacct gtataatcag      780

ctgctgggcg gcatcagcag agaggccggc accgagaaga tcaagggcct gaacgaagtg      840

ctgaacctgg ccatccagaa gaacgacgag acagcccaca tcattgccag cctgccccac      900

cggttcatcc ctctgttcaa gcagatcctg agcgacagaa acaccctgag cttcatcctg      960

gaagagttca agtccgatga ggaagtgatc cagagcttct gcaagtataa gaccctgctg     1020

aggaacgaga atgtgctgga aaccgccgag gccctgttca atgagctgaa cagcatcgac     1080

ctgacccaca tctttatcag ccacaagaag ctggaaacaa tcagcagcgc cctgtctgac     1140

cactgggaca cactgcggaa tgccctgtac gagcggcgga tctctgagct gaccggcaag     1200

atcaccaaga gcgccaaaga aaaggtgcag cggagcctga agcacgagga tatcaacctg     1260

caggaaatca tcagcgccgc tggcaaagaa ctgagcgagg cctttaagca gaaaaccagc     1320

gagatcctgt cccacgccca cgccgcactg gatcagcctc tgcctaccac cctgaagaag     1380

caggaagaga aagagatcct gaagtcccag ctggacagcc tgctgggcct gtaccatctg     1440

ctggattggt tcgccgtgga cgagagcaac gaggtggacc ccgagttctc cgccagactg     1500

acaggcatca aactggaaat ggaacccagc ctgtccttct acaacaaggc cagaaactac     1560

gccaccaaga aaccctacag cgtggaaaag tttaagctga acttccagat gcccaccctg     1620

gccagcggct gggacgtgaa caaagagaag aacaacggcg ccatcctgtt cgtgaagaac     1680

ggactgtact acctgggcat catgcctaag cagaagggca gatacaaggc cctgtccttt     1740

gagcccaccg aaaagaccag cgagggcttt gacaagatgt actacgatta cttccccgac     1800

gccgccaaga tgatccccaa gtgcagcacc cagctgaagg ccgtgaccgc ccactttcag     1860

acccacacca cccccatcct gctgagcaac aacttcatcg agcccctgga aatcaccaaa     1920

gagatctacg acctgaacaa ccccgagaaa gagcccaaga agttccagac cgcctacgcc     1980

aagaaaaccg gcgaccagaa gggctaccgc gaggctctgt gcaagtggat cgactttacc     2040

cgggacttcc tgagcaagta caccaagacc acctccatcg atctgagcag cctgcggccc     2100

agctcccagt acaaggatct gggcgagtac tacgccgagc tgaaccctct gctgtaccac     2160

atcagcttcc agcggatcgc cgaaaaagaa atcatggacg ccgtggaaac cggcaagctg     2220

tacctgttcc agatctataa caaggacttc gccaagggcc accacggcaa gcccaatctg     2280

cacaccctgt actggaccgg cctgtttagc cccgagaatc tggccaagac cagcatcaag     2340

ctgaacggcc aggccgaact gttttaccgg cccaagagcc ggatgaagcg gatggcccat     2400

agactgggcg agaagatgct gaacaagaaa ctgaaggacc agaaaacccc tatccccgac     2460

acactgtatc aggaactgta cgactacgtg aaccaccggc tgagccacga cctgtccgac     2520

gaagctagag cactgctgcc caacgtgatc acaaaagagg tgtcccacga gatcatcaag     2580

gaccggcggt ttacctccga taagttcttc ttccacgtgc ccatcaccct gaactaccag     2640

gccgccaaca gccccagcaa gttcaaccag agagtgaacg cctacctgaa agagcacccc     2700

gagacaccca tcattggcat cgacagaggc gagcggaacc tgatctacat caccgtgatc     2760

gacagcacag gcaaaatcct ggaacagaga agcctgaaca ccatccagca gttcgactac     2820

cagaagaaac tggacaaccg ggaaaaagaa cgggtggccg ccagacaggc ttggagcgtc     2880

gtgggcacca ttaaggacct gaagcagggc tacctgagcc aagtgattca cgagatcgtg     2940

gacctgatga tccactatca ggctgtggtg gtgctggaaa acctgaactt cggcttcaag     3000

agcaagcgga ccggaatcgc cgagaaagcc gtgtaccagc agtttgagaa aatgctgatc     3060

gacaagctga attgcctggt gctgaaagac taccccgctg agaaagtggg aggcgtgctg     3120

aatccctacc agctgaccga ccagttcacc tcctttgcca agatgggaac ccagagcggc     3180

ttcctgttct acgtgccagc cccctacacc agcaagatcg accctctgac cggcttcgtg     3240

gaccccttcg tgtggaaaac catcaagaac cacgagtccc ggaagcactt cctggaaggc     3300

tttgacttcc tgcactacga cgtgaaaaca ggcgatttca tcctgcactt caagatgaat     3360

cggaatctgt ccttccagag gggcctgccc ggcttcatgc ctgcctggga tatcgtgttc     3420

gagaagaatg agacacagtt cgacgccaag ggaaccccct ttatcgccgg caagaggatc     3480

gtgcctgtga tcgagaacca cagattcacc ggcagatacc gggacctgta ccccgccaac     3540

gagctgattg ccctgctgga agagaagggc atcgtgttcc gggacggcag caacatcctg     3600

cccaagctgc tggaaaatga cgacagccac gccatcgata ccatggtggc actgatccgc     3660

agcgtgctgc agatgcggaa cagcaatgcc gccaccggcg aggactacat caatagccca     3720

gtgcgggacc tgaacggcgt gtgcttcgac agcagattcc agaaccccga gtggcccatg     3780

gatgccgacg ccaatggcgc ctaccacatt gccctgaagg gacagctgct gctgaaccat     3840

ctgaaagaga gcaaagacct gaaactgcag aacggcatct ccaaccagga ctggctggcc     3900

tatatccagg aactgcggaa c                                               3921


<210>  17
<211>  3921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  17
atgacccagt tcgagggctt caccaacctg taccaggtgt ccaagaccct gagattcgag       60

ctgatccccc agggcaagac actgaagcac atccaggaac agggcttcat cgaagaggac      120

aaggcccgga acgaccacta caaagagctg aagcccatca tcgaccggat ctacaagacc      180

tacgccgacc agtgcctgca gctggtgcag ctggactggg agaatctgag cgccgccatc      240

gacagctacc ggaaagagaa aaccgaggaa acccggaacg ccctgatcga ggaacaggcc      300

acctacagaa acgccatcca cgactacttc atcggccgga ccgacaacct gaccgacgcc      360

atcaacaagc ggcacgccga gatctataag ggcctgttca aggccgagct gttcaacggc      420

aaggtgctga agcagctggg caccgtgacc accaccgagc acgaaaacgc cctgctgcgg      480

agcttcgaca agttcaccac ctacttcagc ggcttctacg agaaccggaa gaacgtgttc      540

agcgccgagg acatcagcac cgccatcccc cacagaatcg tgcaggacaa cttccccaag      600

ttcaaagaga actgccacat cttcacccgg ctgatcaccg ccgtgcccag cctgagagaa      660

cacttcgaga acgtgaagaa ggccatcggc atcttcgtgt ccaccagcat cgaggaagtg      720

ttcagcttcc cattctacaa ccagctgctg acccagaccc agatcgacct gtataatcag      780

ctgctgggcg gcatcagcag agaggccggc accgagaaga tcaagggcct gaacgaagtg      840

ctgaacctgg ccatccagaa gaacgacgag acagcccaca tcattgccag cctgccccac      900

cggttcatcc ctctgttcaa gcagatcctg agcgacagaa acaccctgag cttcatcctg      960

gaagagttca agtccgatga ggaagtgatc cagagcttct gcaagtataa gaccctgctg     1020

aggaacgaga atgtgctgga aaccgccgag gccctgttca atgagctgaa cagcatcgac     1080

ctgacccaca tctttatcag ccacaagaag ctggaaacaa tcagcagcgc cctgtgcgac     1140

cactgggaca cactgcggaa tgccctgtac gagcggcgga tctctgagct gaccggcaag     1200

atcaccaaga gcgccaaaga aaaggtgcag cggagcctga agcacgagga tatcaacctg     1260

caggaaatca tcagcgccgc tggcaaagaa ctgagcgagg cctttaagca gaaaaccagc     1320

gagatcctgt cccacgccca cgccgcactg gatcagcctc tgcctaccac cctgaagaag     1380

caggaagaga aagagatcct gaagtcccag ctggacagcc tgctgggcct gtaccatctg     1440

ctggattggt tcgccgtgga cgagagcaac gaggtggacc ccgagttctc cgccagactg     1500

acaggcatca aactggaaat ggaacccagc ctgtccttct acaacaaggc cagaaactac     1560

gccaccaaga aaccctacag cgtggaaaag tttaagctga acttccagat gcccaccctg     1620

gccagcggct gggacgtgaa caaagagaag aacaacggcg ccatcctgtt cgtgaagaac     1680

ggactgtact acctgggcat catgcctaag cagaagggca gatacaaggc cctgtccttt     1740

gagcccaccg aaaagaccag cgagggcttt gacaagatgt actacgatta cttccccgac     1800

gccgccaaga tgatccccaa gtctagcacc cagctgaagg ccgtgaccgc ccactttcag     1860

acccacacca cccccatcct gctgagcaac aacttcatcg agcccctgga aatcaccaaa     1920

gagatctacg acctgaacaa ccccgagaaa gagcccaaga agttccagac cgcctacgcc     1980

aagaaaaccg gcgaccagaa gggctaccgc gaggctctgt gcaagtggat cgactttacc     2040

cgggacttcc tgagcaagta caccaagacc acctccatcg atctgagcag cctgcggccc     2100

agctcccagt acaaggatct gggcgagtac tacgccgagc tgaaccctct gctgtaccac     2160

atcagcttcc agcggatcgc cgaaaaagaa atcatggacg ccgtggaaac cggcaagctg     2220

tacctgttcc agatctataa caaggacttc gccaagggcc accacggcaa gcccaatctg     2280

cacaccctgt actggaccgg cctgtttagc cccgagaatc tggccaagac cagcatcaag     2340

ctgaacggcc aggccgaact gttttaccgg cccaagagcc ggatgaagcg gatggcccat     2400

agactgggcg agaagatgct gaacaagaaa ctgaaggacc agaaaacccc tatccccgac     2460

acactgtatc aggaactgta cgactacgtg aaccaccggc tgagccacga cctgtccgac     2520

gaagctagag cactgctgcc caacgtgatc acaaaagagg tgtcccacga gatcatcaag     2580

gaccggcggt ttacctccga taagttcttc ttccacgtgc ccatcaccct gaactaccag     2640

gccgccaaca gccccagcaa gttcaaccag agagtgaacg cctacctgaa agagcacccc     2700

gagacaccca tcattggcat cgacagaggc gagcggaacc tgatctacat caccgtgatc     2760

gacagcacag gcaaaatcct ggaacagaga agcctgaaca ccatccagca gttcgactac     2820

cagaagaaac tggacaaccg ggaaaaagaa cgggtggccg ccagacaggc ttggagcgtc     2880

gtgggcacca ttaaggacct gaagcagggc tacctgagcc aagtgattca cgagatcgtg     2940

gacctgatga tccactatca ggctgtggtg gtgctggaaa acctgaactt cggcttcaag     3000

agcaagcgga ccggaatcgc cgagaaagcc gtgtaccagc agtttgagaa aatgctgatc     3060

gacaagctga attgcctggt gctgaaagac taccccgctg agaaagtggg aggcgtgctg     3120

aatccctacc agctgaccga ccagttcacc tcctttgcca agatgggaac ccagagcggc     3180

ttcctgttct acgtgccagc cccctacacc agcaagatcg accctctgac cggcttcgtg     3240

gaccccttcg tgtggaaaac catcaagaac cacgagtccc ggaagcactt cctggaaggc     3300

tttgacttcc tgcactacga cgtgaaaaca ggcgatttca tcctgcactt caagatgaat     3360

cggaatctgt ccttccagag gggcctgccc ggcttcatgc ctgcctggga tatcgtgttc     3420

gagaagaatg agacacagtt cgacgccaag ggaaccccct ttatcgccgg caagaggatc     3480

gtgcctgtga tcgagaacca cagattcacc ggcagatacc gggacctgta ccccgccaac     3540

gagctgattg ccctgctgga agagaagggc atcgtgttcc gggacggcag caacatcctg     3600

cccaagctgc tggaaaatga cgacagccac gccatcgata ccatggtggc actgatccgc     3660

agcgtgctgc agatgcggaa cagcaatgcc gccaccggcg aggactacat caatagccca     3720

gtgcgggacc tgaacggcgt gtgcttcgac agcagattcc agaaccccga gtggcccatg     3780

gatgccgacg ccaatggcgc ctaccacatt gccctgaagg gacagctgct gctgaaccat     3840

ctgaaagaga gcaaagacct gaaactgcag aacggcatct ccaaccagga ctggctggcc     3900

tatatccagg aactgcggaa c                                               3921


<210>  18
<211>  3921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
atgacccagt tcgagggctt caccaacctg taccaggtgt ccaagaccct gagattcgag       60

ctgatccccc agggcaagac actgaagcac atccaggaac agggcttcat cgaagaggac      120

aaggcccgga acgaccacta caaagagctg aagcccatca tcgaccggat ctacaagacc      180

tacgccgacc agtgcctgca gctggtgcag ctggactggg agaatctgag cgccgccatc      240

gacagctacc ggaaagagaa aaccgaggaa acccggaacg ccctgatcga ggaacaggcc      300

acctacagaa acgccatcca cgactacttc atcggccgga ccgacaacct gaccgacgcc      360

atcaacaagc ggcacgccga gatctataag ggcctgttca aggccgagct gttcaacggc      420

aaggtgctga agcagctggg caccgtgacc accaccgagc acgaaaacgc cctgctgcgg      480

agcttcgaca agttcaccac ctacttcagc ggcttctacg agaaccggaa gaacgtgttc      540

agcgccgagg acatcagcac cgccatcccc cacagaatcg tgcaggacaa cttccccaag      600

ttcaaagaga actgccacat cttcacccgg ctgatcaccg ccgtgcccag cctgagagaa      660

cacttcgaga acgtgaagaa ggccatcggc atcttcgtgt ccaccagcat cgaggaagtg      720

ttcagcttcc cattctacaa ccagctgctg acccagaccc agatcgacct gtataatcag      780

ctgctgggcg gcatcagcag agaggccggc accgagaaga tcaagggcct gaacgaagtg      840

ctgaacctgg ccatccagaa gaacgacgag acagcccaca tcattgccag cctgccccac      900

cggttcatcc ctctgttcaa gcagatcctg agcgacagaa acaccctgag cttcatcctg      960

gaagagttca agtccgatga ggaagtgatc cagagcttct gcaagtataa gaccctgctg     1020

aggaacgaga atgtgctgga aaccgccgag gccctgttca atgagctgaa cagcatcgac     1080

ctgacccaca tctttatcag ccacaagaag ctggaaacaa tcagcagcgc cctgtgcgac     1140

cactgggaca cactgcggaa tgccctgtac gagcggcgga tctctgagct gaccggcaag     1200

atcaccaaga gcgccaaaga aaaggtgcag cggagcctga agcacgagga tatcaacctg     1260

caggaaatca tcagcgccgc tggcaaagaa ctgagcgagg cctttaagca gaaaaccagc     1320

gagatcctgt cccacgccca cgccgcactg gatcagcctc tgcctaccac cctgaagaag     1380

caggaagaga aagagatcct gaagtcccag ctggacagcc tgctgggcct gtaccatctg     1440

ctggattggt tcgccgtgga cgagagcaac gaggtggacc ccgagttctc cgccagactg     1500

acaggcatca aactggaaat ggaacccagc ctgtccttct acaacaaggc cagaaactac     1560

gccaccaaga aaccctacag cgtggaaaag tttaagctga acttccagat gcccaccctg     1620

gccagcggct gggacgtgaa caaagagaag aacaacggcg ccatcctgtt cgtgaagaac     1680

ggactgtact acctgggcat catgcctaag cagaagggca gatacaaggc cctgtccttt     1740

gagcccaccg aaaagaccag cgagggcttt gacaagatgt actacgatta cttccccgac     1800

gccgccaaga tgatccccaa gtgcagcacc cagctgaagg ccgtgaccgc ccactttcag     1860

acccacacca cccccatcct gctgagcaac aacttcatcg agcccctgga aatcaccaaa     1920

gagatctacg acctgaacaa ccccgagaaa gagcccaaga agttccagac cgcctacgcc     1980

aagaaaaccg gcgaccagaa gggctaccgc gaggctctgt ctaagtggat cgactttacc     2040

cgggacttcc tgagcaagta caccaagacc acctccatcg atctgagcag cctgcggccc     2100

agctcccagt acaaggatct gggcgagtac tacgccgagc tgaaccctct gctgtaccac     2160

atcagcttcc agcggatcgc cgaaaaagaa atcatggacg ccgtggaaac cggcaagctg     2220

tacctgttcc agatctataa caaggacttc gccaagggcc accacggcaa gcccaatctg     2280

cacaccctgt actggaccgg cctgtttagc cccgagaatc tggccaagac cagcatcaag     2340

ctgaacggcc aggccgaact gttttaccgg cccaagagcc ggatgaagcg gatggcccat     2400

agactgggcg agaagatgct gaacaagaaa ctgaaggacc agaaaacccc tatccccgac     2460

acactgtatc aggaactgta cgactacgtg aaccaccggc tgagccacga cctgtccgac     2520

gaagctagag cactgctgcc caacgtgatc acaaaagagg tgtcccacga gatcatcaag     2580

gaccggcggt ttacctccga taagttcttc ttccacgtgc ccatcaccct gaactaccag     2640

gccgccaaca gccccagcaa gttcaaccag agagtgaacg cctacctgaa agagcacccc     2700

gagacaccca tcattggcat cgacagaggc gagcggaacc tgatctacat caccgtgatc     2760

gacagcacag gcaaaatcct ggaacagaga agcctgaaca ccatccagca gttcgactac     2820

cagaagaaac tggacaaccg ggaaaaagaa cgggtggccg ccagacaggc ttggagcgtc     2880

gtgggcacca ttaaggacct gaagcagggc tacctgagcc aagtgattca cgagatcgtg     2940

gacctgatga tccactatca ggctgtggtg gtgctggaaa acctgaactt cggcttcaag     3000

agcaagcgga ccggaatcgc cgagaaagcc gtgtaccagc agtttgagaa aatgctgatc     3060

gacaagctga attgcctggt gctgaaagac taccccgctg agaaagtggg aggcgtgctg     3120

aatccctacc agctgaccga ccagttcacc tcctttgcca agatgggaac ccagagcggc     3180

ttcctgttct acgtgccagc cccctacacc agcaagatcg accctctgac cggcttcgtg     3240

gaccccttcg tgtggaaaac catcaagaac cacgagtccc ggaagcactt cctggaaggc     3300

tttgacttcc tgcactacga cgtgaaaaca ggcgatttca tcctgcactt caagatgaat     3360

cggaatctgt ccttccagag gggcctgccc ggcttcatgc ctgcctggga tatcgtgttc     3420

gagaagaatg agacacagtt cgacgccaag ggaaccccct ttatcgccgg caagaggatc     3480

gtgcctgtga tcgagaacca cagattcacc ggcagatacc gggacctgta ccccgccaac     3540

gagctgattg ccctgctgga agagaagggc atcgtgttcc gggacggcag caacatcctg     3600

cccaagctgc tggaaaatga cgacagccac gccatcgata ccatggtggc actgatccgc     3660

agcgtgctgc agatgcggaa cagcaatgcc gccaccggcg aggactacat caatagccca     3720

gtgcgggacc tgaacggcgt gtgcttcgac agcagattcc agaaccccga gtggcccatg     3780

gatgccgacg ccaatggcgc ctaccacatt gccctgaagg gacagctgct gctgaaccat     3840

ctgaaagaga gcaaagacct gaaactgcag aacggcatct ccaaccagga ctggctggcc     3900

tatatccagg aactgcggaa c                                               3921


<210>  19
<211>  3921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  19
atgacccagt tcgagggctt caccaacctg taccaggtgt ccaagaccct gagattcgag       60

ctgatccccc agggcaagac actgaagcac atccaggaac agggcttcat cgaagaggac      120

aaggcccgga acgaccacta caaagagctg aagcccatca tcgaccggat ctacaagacc      180

tacgccgacc agtgcctgca gctggtgcag ctggactggg agaatctgag cgccgccatc      240

gacagctacc ggaaagagaa aaccgaggaa acccggaacg ccctgatcga ggaacaggcc      300

acctacagaa acgccatcca cgactacttc atcggccgga ccgacaacct gaccgacgcc      360

atcaacaagc ggcacgccga gatctataag ggcctgttca aggccgagct gttcaacggc      420

aaggtgctga agcagctggg caccgtgacc accaccgagc acgaaaacgc cctgctgcgg      480

agcttcgaca agttcaccac ctacttcagc ggcttctacg agaaccggaa gaacgtgttc      540

agcgccgagg acatcagcac cgccatcccc cacagaatcg tgcaggacaa cttccccaag      600

ttcaaagaga actgccacat cttcacccgg ctgatcaccg ccgtgcccag cctgagagaa      660

cacttcgaga acgtgaagaa ggccatcggc atcttcgtgt ccaccagcat cgaggaagtg      720

ttcagcttcc cattctacaa ccagctgctg acccagaccc agatcgacct gtataatcag      780

ctgctgggcg gcatcagcag agaggccggc accgagaaga tcaagggcct gaacgaagtg      840

ctgaacctgg ccatccagaa gaacgacgag acagcccaca tcattgccag cctgccccac      900

cggttcatcc ctctgttcaa gcagatcctg agcgacagaa acaccctgag cttcatcctg      960

gaagagttca agtccgatga ggaagtgatc cagagcttct gcaagtataa gaccctgctg     1020

aggaacgaga atgtgctgga aaccgccgag gccctgttca atgagctgaa cagcatcgac     1080

ctgacccaca tctttatcag ccacaagaag ctggaaacaa tcagcagcgc cctgtgcgac     1140

cactgggaca cactgcggaa tgccctgtac gagcggcgga tctctgagct gaccggcaag     1200

atcaccaaga gcgccaaaga aaaggtgcag cggagcctga agcacgagga tatcaacctg     1260

caggaaatca tcagcgccgc tggcaaagaa ctgagcgagg cctttaagca gaaaaccagc     1320

gagatcctgt cccacgccca cgccgcactg gatcagcctc tgcctaccac cctgaagaag     1380

caggaagaga aagagatcct gaagtcccag ctggacagcc tgctgggcct gtaccatctg     1440

ctggattggt tcgccgtgga cgagagcaac gaggtggacc ccgagttctc cgccagactg     1500

acaggcatca aactggaaat ggaacccagc ctgtccttct acaacaaggc cagaaactac     1560

gccaccaaga aaccctacag cgtggaaaag tttaagctga acttccagat gcccaccctg     1620

gccagcggct gggacgtgaa caaagagaag aacaacggcg ccatcctgtt cgtgaagaac     1680

ggactgtact acctgggcat catgcctaag cagaagggca gatacaaggc cctgtccttt     1740

gagcccaccg aaaagaccag cgagggcttt gacaagatgt actacgatta cttccccgac     1800

gccgccaaga tgatccccaa gtgcagcacc cagctgaagg ccgtgaccgc ccactttcag     1860

acccacacca cccccatcct gctgagcaac aacttcatcg agcccctgga aatcaccaaa     1920

gagatctacg acctgaacaa ccccgagaaa gagcccaaga agttccagac cgcctacgcc     1980

aagaaaaccg gcgaccagaa gggctaccgc gaggctctgt gcaagtggat cgactttacc     2040

cgggacttcc tgagcaagta caccaagacc acctccatcg atctgagcag cctgcggccc     2100

agctcccagt acaaggatct gggcgagtac tacgccgagc tgaaccctct gctgtaccac     2160

atcagcttcc agcggatcgc cgaaaaagaa atcatggacg ccgtggaaac cggcaagctg     2220

tacctgttcc agatctataa caaggacttc gccaagggcc accacggcaa gcccaatctg     2280

cacaccctgt actggaccgg cctgtttagc cccgagaatc tggccaagac cagcatcaag     2340

ctgaacggcc aggccgaact gttttaccgg cccaagagcc ggatgaagcg gatggcccat     2400

agactgggcg agaagatgct gaacaagaaa ctgaaggacc agaaaacccc tatccccgac     2460

acactgtatc aggaactgta cgactacgtg aaccaccggc tgagccacga cctgtccgac     2520

gaagctagag cactgctgcc caacgtgatc acaaaagagg tgtcccacga gatcatcaag     2580

gaccggcggt ttacctccga taagttcttc ttccacgtgc ccatcaccct gaactaccag     2640

gccgccaaca gccccagcaa gttcaaccag agagtgaacg cctacctgaa agagcacccc     2700

gagacaccca tcattggcat cgacagaggc gagcggaacc tgatctacat caccgtgatc     2760

gacagcacag gcaaaatcct ggaacagaga agcctgaaca ccatccagca gttcgactac     2820

cagaagaaac tggacaaccg ggaaaaagaa cgggtggccg ccagacaggc ttggagcgtc     2880

gtgggcacca ttaaggacct gaagcagggc tacctgagcc aagtgattca cgagatcgtg     2940

gacctgatga tccactatca ggctgtggtg gtgctggaaa acctgaactt cggcttcaag     3000

agcaagcgga ccggaatcgc cgagaaagcc gtgtaccagc agtttgagaa aatgctgatc     3060

gacaagctga attctctggt gctgaaagac taccccgctg agaaagtggg aggcgtgctg     3120

aatccctacc agctgaccga ccagttcacc tcctttgcca agatgggaac ccagagcggc     3180

ttcctgttct acgtgccagc cccctacacc agcaagatcg accctctgac cggcttcgtg     3240

gaccccttcg tgtggaaaac catcaagaac cacgagtccc ggaagcactt cctggaaggc     3300

tttgacttcc tgcactacga cgtgaaaaca ggcgatttca tcctgcactt caagatgaat     3360

cggaatctgt ccttccagag gggcctgccc ggcttcatgc ctgcctggga tatcgtgttc     3420

gagaagaatg agacacagtt cgacgccaag ggaaccccct ttatcgccgg caagaggatc     3480

gtgcctgtga tcgagaacca cagattcacc ggcagatacc gggacctgta ccccgccaac     3540

gagctgattg ccctgctgga agagaagggc atcgtgttcc gggacggcag caacatcctg     3600

cccaagctgc tggaaaatga cgacagccac gccatcgata ccatggtggc actgatccgc     3660

agcgtgctgc agatgcggaa cagcaatgcc gccaccggcg aggactacat caatagccca     3720

gtgcgggacc tgaacggcgt gtgcttcgac agcagattcc agaaccccga gtggcccatg     3780

gatgccgacg ccaatggcgc ctaccacatt gccctgaagg gacagctgct gctgaaccat     3840

ctgaaagaga gcaaagacct gaaactgcag aacggcatct ccaaccagga ctggctggcc     3900

tatatccagg aactgcggaa c                                               3921


<210>  20
<211>  3921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  20
atgacccagt tcgagggctt caccaacctg taccaggtgt ccaagaccct gagattcgag       60

ctgatccccc agggcaagac actgaagcac atccaggaac agggcttcat cgaagaggac      120

aaggcccgga acgaccacta caaagagctg aagcccatca tcgaccggat ctacaagacc      180

tacgccgacc agtgcctgca gctggtgcag ctggactggg agaatctgag cgccgccatc      240

gacagctacc ggaaagagaa aaccgaggaa acccggaacg ccctgatcga ggaacaggcc      300

acctacagaa acgccatcca cgactacttc atcggccgga ccgacaacct gaccgacgcc      360

atcaacaagc ggcacgccga gatctataag ggcctgttca aggccgagct gttcaacggc      420

aaggtgctga agcagctggg caccgtgacc accaccgagc acgaaaacgc cctgctgcgg      480

agcttcgaca agttcaccac ctacttcagc ggcttctacg agaaccggaa gaacgtgttc      540

agcgccgagg acatcagcac cgccatcccc cacagaatcg tgcaggacaa cttccccaag      600

ttcaaagaga actgccacat cttcacccgg ctgatcaccg ccgtgcccag cctgagagaa      660

cacttcgaga acgtgaagaa ggccatcggc atcttcgtgt ccaccagcat cgaggaagtg      720

ttcagcttcc cattctacaa ccagctgctg acccagaccc agatcgacct gtataatcag      780

ctgctgggcg gcatcagcag agaggccggc accgagaaga tcaagggcct gaacgaagtg      840

ctgaacctgg ccatccagaa gaacgacgag acagcccaca tcattgccag cctgccccac      900

cggttcatcc ctctgttcaa gcagatcctg agcgacagaa acaccctgag cttcatcctg      960

gaagagttca agtccgatga ggaagtgatc cagagcttct gcaagtataa gaccctgctg     1020

aggaacgaga atgtgctgga aaccgccgag gccctgttca atgagctgaa cagcatcgac     1080

ctgacccaca tctttatcag ccacaagaag ctggaaacaa tcagcagcgc cctgtgcgac     1140

cactgggaca cactgcggaa tgccctgtac gagcggcgga tctctgagct gaccggcaag     1200

atcaccaaga gcgccaaaga aaaggtgcag cggagcctga agcacgagga tatcaacctg     1260

caggaaatca tcagcgccgc tggcaaagaa ctgagcgagg cctttaagca gaaaaccagc     1320

gagatcctgt cccacgccca cgccgcactg gatcagcctc tgcctaccac cctgaagaag     1380

caggaagaga aagagatcct gaagtcccag ctggacagcc tgctgggcct gtaccatctg     1440

ctggattggt tcgccgtgga cgagagcaac gaggtggacc ccgagttctc cgccagactg     1500

acaggcatca aactggaaat ggaacccagc ctgtccttct acaacaaggc cagaaactac     1560

gccaccaaga aaccctacag cgtggaaaag tttaagctga acttccagat gcccaccctg     1620

gccagcggct gggacgtgaa caaagagaag aacaacggcg ccatcctgtt cgtgaagaac     1680

ggactgtact acctgggcat catgcctaag cagaagggca gatacaaggc cctgtccttt     1740

gagcccaccg aaaagaccag cgagggcttt gacaagatgt actacgatta cttccccgac     1800

gccgccaaga tgatccccaa gtgcagcacc cagctgaagg ccgtgaccgc ccactttcag     1860

acccacacca cccccatcct gctgagcaac aacttcatcg agcccctgga aatcaccaaa     1920

gagatctacg acctgaacaa ccccgagaaa gagcccaaga agttccagac cgcctacgcc     1980

aagaaaaccg gcgaccagaa gggctaccgc gaggctctgt gcaagtggat cgactttacc     2040

cgggacttcc tgagcaagta caccaagacc acctccatcg atctgagcag cctgcggccc     2100

agctcccagt acaaggatct gggcgagtac tacgccgagc tgaaccctct gctgtaccac     2160

atcagcttcc agcggatcgc cgaaaaagaa atcatggacg ccgtggaaac cggcaagctg     2220

tacctgttcc agatctataa caaggacttc gccaagggcc accacggcaa gcccaatctg     2280

cacaccctgt actggaccgg cctgtttagc cccgagaatc tggccaagac cagcatcaag     2340

ctgaacggcc aggccgaact gttttaccgg cccaagagcc ggatgaagcg gatggcccat     2400

agactgggcg agaagatgct gaacaagaaa ctgaaggacc agaaaacccc tatccccgac     2460

acactgtatc aggaactgta cgactacgtg aaccaccggc tgagccacga cctgtccgac     2520

gaagctagag cactgctgcc caacgtgatc acaaaagagg tgtcccacga gatcatcaag     2580

gaccggcggt ttacctccga taagttcttc ttccacgtgc ccatcaccct gaactaccag     2640

gccgccaaca gccccagcaa gttcaaccag agagtgaacg cctacctgaa agagcacccc     2700

gagacaccca tcattggcat cgacagaggc gagcggaacc tgatctacat caccgtgatc     2760

gacagcacag gcaaaatcct ggaacagaga agcctgaaca ccatccagca gttcgactac     2820

cagaagaaac tggacaaccg ggaaaaagaa cgggtggccg ccagacaggc ttggagcgtc     2880

gtgggcacca ttaaggacct gaagcagggc tacctgagcc aagtgattca cgagatcgtg     2940

gacctgatga tccactatca ggctgtggtg gtgctggaaa acctgaactt cggcttcaag     3000

agcaagcgga ccggaatcgc cgagaaagcc gtgtaccagc agtttgagaa aatgctgatc     3060

gacaagctga attgcctggt gctgaaagac taccccgctg agaaagtggg aggcgtgctg     3120

aatccctacc agctgaccga ccagttcacc tcctttgcca agatgggaac ccagagcggc     3180

ttcctgttct acgtgccagc cccctacacc agcaagatcg accctctgac cggcttcgtg     3240

gaccccttcg tgtggaaaac catcaagaac cacgagtccc ggaagcactt cctggaaggc     3300

tttgacttcc tgcactacga cgtgaaaaca ggcgatttca tcctgcactt caagatgaat     3360

cggaatctgt ccttccagag gggcctgccc ggcttcatgc ctgcctggga tatcgtgttc     3420

gagaagaatg agacacagtt cgacgccaag ggaaccccct ttatcgccgg caagaggatc     3480

gtgcctgtga tcgagaacca cagattcacc ggcagatacc gggacctgta ccccgccaac     3540

gagctgattg ccctgctgga agagaagggc atcgtgttcc gggacggcag caacatcctg     3600

cccaagctgc tggaaaatga cgacagccac gccatcgata ccatggtggc actgatccgc     3660

agcgtgctgc agatgcggaa cagcaatgcc gccaccggcg aggactacat caatagccca     3720

gtgcgggacc tgaacggcgt gtctttcgac agcagattcc agaaccccga gtggcccatg     3780

gatgccgacg ccaatggcgc ctaccacatt gccctgaagg gacagctgct gctgaaccat     3840

ctgaaagaga gcaaagacct gaaactgcag aacggcatct ccaaccagga ctggctggcc     3900

tatatccagg aactgcggaa c                                               3921


<210>  21
<211>  3921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  21
atgacccagt tcgagggctt caccaacctg taccaggtgt ccaagaccct gagattcgag       60

ctgatccccc agggcaagac actgaagcac atccaggaac agggcttcat cgaagaggac      120

aaggcccgga acgaccacta caaagagctg aagcccatca tcgaccggat ctacaagacc      180

tacgccgacc agtgcctgca gctggtgcag ctggactggg agaatctgag cgccgccatc      240

gacagctacc ggaaagagaa aaccgaggaa acccggaacg ccctgatcga ggaacaggcc      300

acctacagaa acgccatcca cgactacttc atcggccgga ccgacaacct gaccgacgcc      360

atcaacaagc ggcacgccga gatctataag ggcctgttca aggccgagct gttcaacggc      420

aaggtgctga agcagctggg caccgtgacc accaccgagc acgaaaacgc cctgctgcgg      480

agcttcgaca agttcaccac ctacttcagc ggcttctacg agaaccggaa gaacgtgttc      540

agcgccgagg acatcagcac cgccatcccc cacagaatcg tgcaggacaa cttccccaag      600

ttcaaagaga actctcacat cttcacccgg ctgatcaccg ccgtgcccag cctgagagaa      660

cacttcgaga acgtgaagaa ggccatcggc atcttcgtgt ccaccagcat cgaggaagtg      720

ttcagcttcc cattctacaa ccagctgctg acccagaccc agatcgacct gtataatcag      780

ctgctgggcg gcatcagcag agaggccggc accgagaaga tcaagggcct gaacgaagtg      840

ctgaacctgg ccatccagaa gaacgacgag acagcccaca tcattgccag cctgccccac      900

cggttcatcc ctctgttcaa gcagatcctg agcgacagaa acaccctgag cttcatcctg      960

gaagagttca agtccgatga ggaagtgatc cagagcttct gcaagtataa gaccctgctg     1020

aggaacgaga atgtgctgga aaccgccgag gccctgttca atgagctgaa cagcatcgac     1080

ctgacccaca tctttatcag ccacaagaag ctggaaacaa tcagcagcgc cctgtctgac     1140

cactgggaca cactgcggaa tgccctgtac gagcggcgga tctctgagct gaccggcaag     1200

atcaccaaga gcgccaaaga aaaggtgcag cggagcctga agcacgagga tatcaacctg     1260

caggaaatca tcagcgccgc tggcaaagaa ctgagcgagg cctttaagca gaaaaccagc     1320

gagatcctgt cccacgccca cgccgcactg gatcagcctc tgcctaccac cctgaagaag     1380

caggaagaga aagagatcct gaagtcccag ctggacagcc tgctgggcct gtaccatctg     1440

ctggattggt tcgccgtgga cgagagcaac gaggtggacc ccgagttctc cgccagactg     1500

acaggcatca aactggaaat ggaacccagc ctgtccttct acaacaaggc cagaaactac     1560

gccaccaaga aaccctacag cgtggaaaag tttaagctga acttccagat gcccaccctg     1620

gccagcggct gggacgtgaa caaagagaag aacaacggcg ccatcctgtt cgtgaagaac     1680

ggactgtact acctgggcat catgcctaag cagaagggca gatacaaggc cctgtccttt     1740

gagcccaccg aaaagaccag cgagggcttt gacaagatgt actacgatta cttccccgac     1800

gccgccaaga tgatccccaa gtgcagcacc cagctgaagg ccgtgaccgc ccactttcag     1860

acccacacca cccccatcct gctgagcaac aacttcatcg agcccctgga aatcaccaaa     1920

gagatctacg acctgaacaa ccccgagaaa gagcccaaga agttccagac cgcctacgcc     1980

aagaaaaccg gcgaccagaa gggctaccgc gaggctctgt ctaagtggat cgactttacc     2040

cgggacttcc tgagcaagta caccaagacc acctccatcg atctgagcag cctgcggccc     2100

agctcccagt acaaggatct gggcgagtac tacgccgagc tgaaccctct gctgtaccac     2160

atcagcttcc agcggatcgc cgaaaaagaa atcatggacg ccgtggaaac cggcaagctg     2220

tacctgttcc agatctataa caaggacttc gccaagggcc accacggcaa gcccaatctg     2280

cacaccctgt actggaccgg cctgtttagc cccgagaatc tggccaagac cagcatcaag     2340

ctgaacggcc aggccgaact gttttaccgg cccaagagcc ggatgaagcg gatggcccat     2400

agactgggcg agaagatgct gaacaagaaa ctgaaggacc agaaaacccc tatccccgac     2460

acactgtatc aggaactgta cgactacgtg aaccaccggc tgagccacga cctgtccgac     2520

gaagctagag cactgctgcc caacgtgatc acaaaagagg tgtcccacga gatcatcaag     2580

gaccggcggt ttacctccga taagttcttc ttccacgtgc ccatcaccct gaactaccag     2640

gccgccaaca gccccagcaa gttcaaccag agagtgaacg cctacctgaa agagcacccc     2700

gagacaccca tcattggcat cgacagaggc gagcggaacc tgatctacat caccgtgatc     2760

gacagcacag gcaaaatcct ggaacagaga agcctgaaca ccatccagca gttcgactac     2820

cagaagaaac tggacaaccg ggaaaaagaa cgggtggccg ccagacaggc ttggagcgtc     2880

gtgggcacca ttaaggacct gaagcagggc tacctgagcc aagtgattca cgagatcgtg     2940

gacctgatga tccactatca ggctgtggtg gtgctggaaa acctgaactt cggcttcaag     3000

agcaagcgga ccggaatcgc cgagaaagcc gtgtaccagc agtttgagaa aatgctgatc     3060

gacaagctga attgcctggt gctgaaagac taccccgctg agaaagtggg aggcgtgctg     3120

aatccctacc agctgaccga ccagttcacc tcctttgcca agatgggaac ccagagcggc     3180

ttcctgttct acgtgccagc cccctacacc agcaagatcg accctctgac cggcttcgtg     3240

gaccccttcg tgtggaaaac catcaagaac cacgagtccc ggaagcactt cctggaaggc     3300

tttgacttcc tgcactacga cgtgaaaaca ggcgatttca tcctgcactt caagatgaat     3360

cggaatctgt ccttccagag gggcctgccc ggcttcatgc ctgcctggga tatcgtgttc     3420

gagaagaatg agacacagtt cgacgccaag ggaaccccct ttatcgccgg caagaggatc     3480

gtgcctgtga tcgagaacca cagattcacc ggcagatacc gggacctgta ccccgccaac     3540

gagctgattg ccctgctgga agagaagggc atcgtgttcc gggacggcag caacatcctg     3600

cccaagctgc tggaaaatga cgacagccac gccatcgata ccatggtggc actgatccgc     3660

agcgtgctgc agatgcggaa cagcaatgcc gccaccggcg aggactacat caatagccca     3720

gtgcgggacc tgaacggcgt gtctttcgac agcagattcc agaaccccga gtggcccatg     3780

gatgccgacg ccaatggcgc ctaccacatt gccctgaagg gacagctgct gctgaaccat     3840

ctgaaagaga gcaaagacct gaaactgcag aacggcatct ccaaccagga ctggctggcc     3900

tatatccagg aactgcggaa c                                               3921


<210>  22
<211>  3921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  22
atgacccagt tcgagggctt caccaacctg taccaggtgt ccaagaccct gagattcgag       60

ctgatccccc agggcaagac actgaagcac atccaggaac agggcttcat cgaagaggac      120

aaggcccgga acgaccacta caaagagctg aagcccatca tctaccggat ctacaagacc      180

tacgccgacc agtgcctgca gctggtgcag ctggactggg agaatctgag cgccgccatc      240

gacagctacc ggaaagagaa aaccgaggaa acccggaacg ccctgatcga ggaacaggcc      300

acctacagaa acgccatcca cgactacttc atcggccgga ccgacaacct gaccgacgcc      360

atcaacaagc ggcacgccga gatctataag ggcctgttca aggccgagct gttcaacggc      420

aaggtgctga agcagctggg caccgtgacc accaccgagc acgaaaacgc cctgctgcgg      480

agcttcgaca agttcaccac ctacttcagc ggcttctacg agaaccggaa gaacgtgttc      540

agcgccgagg acatcagcac cgccatcccc cacagaatcg tgcaggacaa cttccccaag      600

ttcaaagaga actctcacat cttcacccgg ctgatcaccg ccgtgcccag cctgagagaa      660

cacttcgaga acgtgaagaa ggccatcggc atcttcgtgt ccaccagcat cgaggaagtg      720

ttcagcttcc cattctacaa ccagctgctg acccagaccc agatcgacct gtataatcag      780

ctgctgggcg gcatcagcag agaggccggc accgagaaga tcaagggcct gaacgaagtg      840

ctgaacctgg ccatccagaa gaacgacgag acagcccaca tcattgccag cctgccccac      900

cggttcatcc ctctgttcaa gcagatcctg agcgacagaa acaccctgag cttcatcctg      960

gaagagttca agtccgatga ggaagtgatc cagagcttct ctaagtataa gaccctgctg     1020

aggaacgaga atgtgctgga aaccgccgag gccctgttca atgagctgaa cagcatcgac     1080

ctgacccaca tctttatcag ccacaagaag ctggaaacaa tcagcagcgc cctgtctgac     1140

cactgggaca cactgcggaa tgccctgtac gagcggcgga tctctgagct gaccggcaag     1200

atcaccaaga gcgccaaaga aaaggtgcag cggagcctga agcacgagga tatcaacctg     1260

caggaaatca tcagcgccgc tggcaaagaa ctgagcgagg cctttaagca gaaaaccagc     1320

gagatcctgt cccacgccca cgccgcactg gatcagcctc tgcctaccac cctgaagaag     1380

caggaagaga aagagatcct gaagtcccag ctggacagcc tgctgggcct gtaccatctg     1440

ctggattggt tcgccgtgga cgagagcaac gaggtggacc ccgagttctc cgccagactg     1500

acaggcatca aactggaaat ggaacccagc ctgtccttct acaacaaggc cagaaactac     1560

gccaccaaga aaccctacag cgtggaaaag tttaagctga acttccagat gcccaccctg     1620

gccagcggct gggacgtgaa caaagagaag aacaacggcg ccatcctgtt cgtgaagaac     1680

ggactgtact acctgggcat catgcctaag cagaagggca gatacaaggc cctgtccttt     1740

gagcccaccg aaaagaccag cgagggcttt gacaagatgt actacgatta cttccccgac     1800

gccgccaaga tgatccccaa gtgcagcacc cagctgaagg ccgtgaccgc ccactttcag     1860

acccacacca cccccatcct gctgagcaac aacttcatcg agcccctgga aatcaccaaa     1920

gagatctacg acctgaacaa ccccgagaaa gagcccaaga agttccagac cgcctacgcc     1980

aagaaaaccg gcgaccagaa gggctaccgc gaggctctgt ctaagtggat cgactttacc     2040

cgggacttcc tgagcaagta caccaagacc acctccatcg atctgagcag cctgcggccc     2100

agctcccagt acaaggatct gggcgagtac tacgccgagc tgaaccctct gctgtaccac     2160

atcagcttcc agcggatcgc cgaaaaagaa atcatggacg ccgtggaaac cggcaagctg     2220

tacctgttcc agatctataa caaggacttc gccaagggcc accacggcaa gcccaatctg     2280

cacaccctgt actggaccgg cctgtttagc cccgagaatc tggccaagac cagcatcaag     2340

ctgaacggcc aggccgaact gttttaccgg cccaagagcc ggatgaagcg gatggcccat     2400

agactgggcg agaagatgct gaacaagaaa ctgaaggacc agaaaacccc tatccccgac     2460

acactgtatc aggaactgta cgactacgtg aaccaccggc tgagccacga cctgtccgac     2520

gaagctagag cactgctgcc caacgtgatc acaaaagagg tgtcccacga gatcatcaag     2580

gaccggcggt ttacctccga taagttcttc ttccacgtgc ccatcaccct gaactaccag     2640

gccgccaaca gccccagcaa gttcaaccag agagtgaacg cctacctgaa agagcacccc     2700

gagacaccca tcattggcat cgacagaggc gagcggaacc tgatctacat caccgtgatc     2760

gacagcacag gcaaaatcct ggaacagaga agcctgaaca ccatccagca gttcgactac     2820

cagaagaaac tggacaaccg ggaaaaagaa cgggtggccg ccagacaggc ttggagcgtc     2880

gtgggcacca ttaaggacct gaagcagggc tacctgagcc aagtgattca cgagatcgtg     2940

gacctgatga tccactatca ggctgtggtg gtgctggaaa acctgaactt cggcttcaag     3000

agcaagcgga ccggaatcgc cgagaaagcc gtgtaccagc agtttgagaa aatgctgatc     3060

gacaagctga attgcctggt gctgaaagac taccccgctg agaaagtggg aggcgtgctg     3120

aatccctacc agctgaccga ccagttcacc tcctttgcca agatgggaac ccagagcggc     3180

ttcctgttct acgtgccagc cccctacacc agcaagatcg accctctgac cggcttcgtg     3240

gaccccttcg tgtggaaaac catcaagaac cacgagtccc ggaagcactt cctggaaggc     3300

tttgacttcc tgcactacga cgtgaaaaca ggcgatttca tcctgcactt caagatgaat     3360

cggaatctgt ccttccagag gggcctgccc ggcttcatgc ctgcctggga tatcgtgttc     3420

gagaagaatg agacacagtt cgacgccaag ggaaccccct ttatcgccgg caagaggatc     3480

gtgcctgtga tcgagaacca cagattcacc ggcagatacc gggacctgta ccccgccaac     3540

gagctgattg ccctgctgga agagaagggc atcgtgttcc gggacggcag caacatcctg     3600

cccaagctgc tggaaaatga cgacagccac gccatcgata ccatggtggc actgatccgc     3660

agcgtgctgc agatgcggaa cagcaatgcc gccaccggcg aggactacat caatagccca     3720

gtgcgggacc tgaacggcgt gtctttcgac agcagattcc agaaccccga gtggcccatg     3780

gatgccgacg ccaatggcgc ctaccacatt gccctgaagg gacagctgct gctgaaccat     3840

ctgaaagaga gcaaagacct gaaactgcag aacggcatct ccaaccagga ctggctggcc     3900

tatatccagg aactgcggaa c                                               3921


