                         SEQUENCE LISTING

<110>  Genome Research Limited
 
<120>  NOVEL TRYPANOSOMAL VACCINE

<130>  WEL-C-P2500PCT

<150>  GB 1900192.4
<151>  2019-01-07

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  532
<212>  PRT
<213>  T. vivax

<400>  1

Met Arg Cys His Glu Pro Pro Thr Pro Pro Gln Leu Ser Ala Thr Cys 
1               5                   10                  15      


Cys Val Ala Glu Glu Ile Asp Thr Tyr Asn Lys His Leu Asp Ala Leu 
            20                  25                  30          


Met Gln Ile Ile Gly Asp Ala Ile Lys Asn Ile Ser Thr Asn Glu Asp 
        35                  40                  45              


Asn Ala Arg Ala Arg Ala Glu Gly Leu Lys Gly Cys Asn Leu His Tyr 
    50                  55                  60                  


Val Gln Phe Ala Val Ala His Thr Glu Gly Ser Val Val Ala Ala Arg 
65                  70                  75                  80  


Arg Glu Ala Val Lys Ala Gln Asn Thr Ile Lys Gly Ser Thr Ser Leu 
                85                  90                  95      


Leu Lys Lys Val Thr Ile Asp Ile Ser Asn Ser Phe Arg Asn Ile Ser 
            100                 105                 110         


Ser Lys Cys Asn Glu Leu Arg Glu Lys Tyr Pro Ser Leu Ile Pro Ala 
        115                 120                 125             


Asp Lys Asn Ser Pro Pro Asn Ile Thr Phe Lys Lys Ala Val Gln Leu 
    130                 135                 140                 


Tyr Val Lys Asn Phe Ser Thr Cys Asn Val Met Tyr Ala Lys Lys Leu 
145                 150                 155                 160 


Leu Arg Leu Val Ala Gln Ser Glu Lys Ile Glu Ala Glu Val Ser Arg 
                165                 170                 175     


Ala Val Glu Arg Thr Asn Ala Ser Thr Met Glu Leu Ala Lys Leu Asp 
            180                 185                 190         


Lys Val Ala Val Gln Leu Asn Lys Asp Ile Thr Ser Asn Arg Thr Trp 
        195                 200                 205             


Ala Gly Cys Lys Leu Ala Glu Tyr His Gly Gln Met Asn Phe Val Phe 
    210                 215                 220                 


Met Gly Phe Tyr Val Leu Leu Ser Asp Ile Leu Asp Glu Leu His Ser 
225                 230                 235                 240 


Leu Leu Lys Lys Ser Lys Ser Met Gln Pro Thr Arg Leu Thr Gln Glu 
                245                 250                 255     


Glu Val Arg Arg Ala Leu Ser Lys Ala Glu Gln Val Cys His Asp Val 
            260                 265                 270         


Ser Arg Phe Val Lys Ser Leu Gly Ser Thr Leu Arg Asp Phe Thr Asn 
        275                 280                 285             


Phe Val His Arg Leu Arg Lys Glu Tyr Leu His Gly Ile Leu Arg Asn 
    290                 295                 300                 


Ala Ser Gly Phe Arg Glu Ser Phe Glu Arg Cys Tyr Lys Val Ala Thr 
305                 310                 315                 320 


Asn Asn Ser Val Thr Arg Leu Glu Ser Thr Val Glu Glu Ile Thr Ala 
                325                 330                 335     


Asn Asn Glu Asn Ile Ala Ala Trp Glu Ser Met Thr Val His Gln Trp 
            340                 345                 350         


Lys Asp Val Ser Lys Lys Leu Arg Gln Ser Leu Leu Thr Val Leu Gly 
        355                 360                 365             


Gly Ser Asn Glu Tyr Ile Leu Leu Tyr Gly Tyr Phe Gln Glu Phe Asp 
    370                 375                 380                 


Ser Met Ser Val Arg Glu Phe Ser Asn Thr Val Arg Ala Phe Arg Gln 
385                 390                 395                 400 


Ser Ile Thr Glu Met Ser Val Ala Arg Asn Val Val Gly Val Ala Ala 
                405                 410                 415     


Lys Thr Val Ala Ala Asp Arg Lys Arg Ile Leu Cys Arg Ser Val Leu 
            420                 425                 430         


Met Phe Asn Lys Gly Thr Ala Gly Ser Glu Ser Ala Arg Lys Leu Tyr 
        435                 440                 445             


Glu Leu Cys Lys Thr Arg Met Pro Val Glu Glu Pro Asp Ser Ser Arg 
    450                 455                 460                 


Glu Asp Gly Val Val Gly Thr Ser Gly Ser Glu Glu Glu Ile Ser Gly 
465                 470                 475                 480 


Lys Asp Gly Gly Thr Ser Phe Ser Val Ser Asp Ala Asp Tyr Trp Glu 
                485                 490                 495     


Trp Asp Val Pro Pro Lys Val Leu Glu Glu Ser Ser Gly Asp Leu Leu 
            500                 505                 510         


Tyr Asp Thr Ala Val Asp Leu His Thr Lys Arg Lys Ser Pro Phe Tyr 
        515                 520                 525             


Gln Val Gly Ser 
    530         


<210>  2
<211>  607
<212>  PRT
<213>  T. vivax

<400>  2

Met Glu Val Met Leu Phe Asp Tyr Phe His Val Leu Pro Ile Ser Cys 
1               5                   10                  15      


Lys Pro Arg Asn Phe Cys Ile Ala Phe Met Leu Met Phe Leu Arg Phe 
            20                  25                  30          


Cys Pro Val Phe Ala Met Arg Cys His Glu Pro Pro Thr Pro Pro Gln 
        35                  40                  45              


Leu Ser Ala Thr Cys Cys Val Ala Glu Glu Ile Asp Thr Tyr Asn Lys 
    50                  55                  60                  


His Leu Asp Ala Leu Met Gln Ile Ile Gly Asp Ala Ile Lys Asn Ile 
65                  70                  75                  80  


Ser Thr Asn Glu Asp Asn Ala Arg Ala Arg Ala Glu Gly Leu Lys Gly 
                85                  90                  95      


Cys Asn Leu His Tyr Val Gln Phe Ala Val Ala His Thr Glu Gly Ser 
            100                 105                 110         


Val Val Ala Ala Arg Arg Glu Ala Val Lys Ala Gln Asn Thr Ile Lys 
        115                 120                 125             


Gly Ser Thr Ser Leu Leu Lys Lys Val Thr Ile Asp Ile Ser Asn Ser 
    130                 135                 140                 


Phe Arg Asn Ile Ser Ser Lys Cys Asn Glu Leu Arg Glu Lys Tyr Pro 
145                 150                 155                 160 


Ser Leu Ile Pro Ala Asp Lys Asn Ser Pro Pro Asn Ile Thr Phe Lys 
                165                 170                 175     


Lys Ala Val Gln Leu Tyr Val Lys Asn Phe Ser Thr Cys Asn Val Met 
            180                 185                 190         


Tyr Ala Lys Lys Leu Leu Arg Leu Val Ala Gln Ser Glu Lys Ile Glu 
        195                 200                 205             


Ala Glu Val Ser Arg Ala Val Glu Arg Thr Asn Ala Ser Thr Met Glu 
    210                 215                 220                 


Leu Ala Lys Leu Asp Lys Val Ala Val Gln Leu Asn Lys Asp Ile Thr 
225                 230                 235                 240 


Ser Asn Arg Thr Trp Ala Gly Cys Lys Leu Ala Glu Tyr His Gly Gln 
                245                 250                 255     


Met Asn Phe Val Phe Met Gly Phe Tyr Val Leu Leu Ser Asp Ile Leu 
            260                 265                 270         


Asp Glu Leu His Ser Leu Leu Lys Lys Ser Lys Ser Met Gln Pro Thr 
        275                 280                 285             


Arg Leu Thr Gln Glu Glu Val Arg Arg Ala Leu Ser Lys Ala Glu Gln 
    290                 295                 300                 


Val Cys His Asp Val Ser Arg Phe Val Lys Ser Leu Gly Ser Thr Leu 
305                 310                 315                 320 


Arg Asp Phe Thr Asn Phe Val His Arg Leu Arg Lys Glu Tyr Leu His 
                325                 330                 335     


Gly Ile Leu Arg Asn Ala Ser Gly Phe Arg Glu Ser Phe Glu Arg Cys 
            340                 345                 350         


Tyr Lys Val Ala Thr Asn Asn Ser Val Thr Arg Leu Glu Ser Thr Val 
        355                 360                 365             


Glu Glu Ile Thr Ala Asn Asn Glu Asn Ile Ala Ala Trp Glu Ser Met 
    370                 375                 380                 


Thr Val His Gln Trp Lys Asp Val Ser Lys Lys Leu Arg Gln Ser Leu 
385                 390                 395                 400 


Leu Thr Val Leu Gly Gly Ser Asn Glu Tyr Ile Leu Leu Tyr Gly Tyr 
                405                 410                 415     


Phe Gln Glu Phe Asp Ser Met Ser Val Arg Glu Phe Ser Asn Thr Val 
            420                 425                 430         


Arg Ala Phe Arg Gln Ser Ile Thr Glu Met Ser Val Ala Arg Asn Val 
        435                 440                 445             


Val Gly Val Ala Ala Lys Thr Val Ala Ala Asp Arg Lys Arg Ile Leu 
    450                 455                 460                 


Cys Arg Ser Val Leu Met Phe Asn Lys Gly Thr Ala Gly Ser Glu Ser 
465                 470                 475                 480 


Ala Arg Lys Leu Tyr Glu Leu Cys Lys Thr Arg Met Pro Val Glu Glu 
                485                 490                 495     


Pro Asp Ser Ser Arg Glu Asp Gly Val Val Gly Thr Ser Gly Ser Glu 
            500                 505                 510         


Glu Glu Ile Ser Gly Lys Asp Gly Gly Thr Ser Phe Ser Val Ser Asp 
        515                 520                 525             


Ala Asp Tyr Trp Glu Trp Asp Val Pro Pro Lys Val Leu Glu Glu Ser 
    530                 535                 540                 


Ser Gly Asp Leu Leu Tyr Asp Thr Ala Val Asp Leu His Thr Lys Arg 
545                 550                 555                 560 


Lys Ser Pro Phe Tyr Gln Val Gly Ser Ile Ala Phe Gly Val Phe Leu 
                565                 570                 575     


Leu Val Val Ser Cys Gly Val Gly Ile Leu Met Phe Val Arg Arg Trp 
            580                 585                 590         


Tyr Ala Ala Cys Val Ala Arg Ser Ala Asp Gly Gly Thr Asp Cys 
        595                 600                 605         


<210>  3
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  3
gcacctaacg ctgcaggtgg accatccg                                          28


<210>  4
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  4
tggtccacct gcagcgttag gtgctgggc                                         29


<210>  5
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  5
caaagacctc gctgcgccca tcgagagaac c                                      31


<210>  6
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Primer

<400>  6
gatggcgcag cgaggtcttt gttgttgacc                                        30


