                         SEQUENCE LISTING

<110>  Genome Research Limited
 
<120>  NOVEL TRYPANOSOMAL VACCINE

<130>  WEL-C-P2499PCT

<150>  GB 1900187.4
<151>  2019-01-07

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  553
<212>  PRT
<213>  T. vivax

<400>  1

Ile Asp Asp Glu Gly Glu Ser Ala Gln Phe Arg Thr Trp Val Cys Lys 
1               5                   10                  15      


Trp Glu Gln Lys Arg Thr Val Leu Leu Tyr Tyr Ile Arg Val Leu Ile 
            20                  25                  30          


Ala Lys Thr Ala Arg Asp Ala Gly Ala Leu Arg Gln Gln Arg Ala Ala 
        35                  40                  45              


Phe Phe Glu Ala Trp Ser Asn Ala Val Ser Leu Arg Asn Leu Lys Asn 
    50                  55                  60                  


Val Ala Lys Lys Val Lys Lys Ala Thr Glu Ala Val Asp Trp Ala Thr 
65                  70                  75                  80  


Gln Cys Glu Gly Val Met Phe Met Thr Leu Gln Thr Ile Ile Arg Ala 
                85                  90                  95      


Leu Asn Thr Met Arg Gly His Val Ser Asp Lys Asp Gly Thr Ala Pro 
            100                 105                 110         


Ser Asp Cys Gly Leu Glu Pro His Gln Gly Arg Ala Ala Asp Arg Asn 
        115                 120                 125             


Met Thr Tyr Val Glu Val Ile Glu His Ile Lys Ser Thr Glu Arg Arg 
    130                 135                 140                 


Leu Gln Glu Leu Ser Met Phe Ala Glu Glu Ser Val Arg Thr Phe Tyr 
145                 150                 155                 160 


Gly Asn Tyr Val Asn Gly Val Gly Leu Leu Asn Asp Thr Asn Asn Tyr 
                165                 170                 175     


Phe Ala Ala Ala Glu Ala Ala Arg Arg Ala Leu Arg Glu Ala Asp Glu 
            180                 185                 190         


Ala Met Lys Asp Ala Ser Asp Arg Lys Glu Leu Asn Glu Lys Arg Val 
        195                 200                 205             


Gln Leu Gly Cys Glu Val Glu Lys Gly Leu Phe Phe Met Arg Glu Ile 
    210                 215                 220                 


Phe Leu Thr Leu His Ser Val Ser Glu Arg Val Ile Ser Arg Glu Arg 
225                 230                 235                 240 


Ala Leu Lys Ala Lys Val Gly Glu Leu Asp Glu Gly Pro Gly Ala Cys 
                245                 250                 255     


Gly Met Ala His Thr Met Phe Arg Ser Thr Ala Tyr Ala Asn Leu Arg 
            260                 265                 270         


Ala Ser Ser Ala Lys Asp Glu Ser Ser Leu Ala Val Val Glu Leu Ser 
        275                 280                 285             


Glu Phe Met Gly Ile Lys Gly His Ser Thr Leu His His Glu Leu Glu 
    290                 295                 300                 


Tyr Asp Asp Asp Phe Lys Ile Ser Leu Thr Asn Cys Arg Asp Ser Glu 
305                 310                 315                 320 


Leu Glu Gln Ser Leu Val Phe Arg Phe Ala Arg Gly Glu Glu Asn Asp 
                325                 330                 335     


Asn Ile Tyr Asp Phe Asp Arg Trp Arg Ala Ala Ala Asp Glu Leu Trp 
            340                 345                 350         


Asn Lys Val Glu Ser His Thr His Ile Ile Ser Glu Lys Cys Thr Lys 
        355                 360                 365             


Val Ser Gly Val Asp Cys Ser Glu Ala Val Gly Ala Val Thr Met Leu 
    370                 375                 380                 


Ile Gly Arg Leu Arg Gln Leu Glu Gly Asp Leu Glu Arg Gly Leu Gly 
385                 390                 395                 400 


Ala Ala Ile Arg Ala Leu Lys Thr Val Glu Asp Gly Ile Ala Thr Ser 
                405                 410                 415     


Gln Asp Ala Met Arg Lys Cys Gln His Gly Gly Ala Val Asn Glu His 
            420                 425                 430         


His Thr Glu Ala Lys Glu Pro Gln Thr Thr Ser Gly Arg Arg Glu Ala 
        435                 440                 445             


Asn Thr Asp Ser Ala Pro Ala Lys Glu Gln Leu Asp Ala Ala Ser Lys 
    450                 455                 460                 


Leu Glu Gly Gly Ser Arg Leu Glu Glu Glu Val Asp Gly Asn Glu Lys 
465                 470                 475                 480 


Glu Glu Gln Gln Glu Ala Pro Ala Asn Gly Pro Gln Gly Ala Leu Gly 
                485                 490                 495     


Val Arg Gln Glu Glu Thr Ser Tyr Glu Gly Asp Ala Gly Arg Gly Ser 
            500                 505                 510         


Val Asp Thr Gly His Asp Glu Phe Ala Thr Tyr Leu Ala Ser Arg Ser 
        515                 520                 525             


Ala Cys Ser Thr Ala Gly Asp Gly Ile Glu Ser Ser Ser Thr Ala Gly 
    530                 535                 540                 


Asp Ala Ala Ala Val Glu Ala Arg Ser 
545                 550             


<210>  2
<211>  606
<212>  PRT
<213>  T. vivax

<400>  2

Met Leu Ala Tyr Lys Leu Ile Leu Cys Ser Thr Val Phe Leu Leu Cys 
1               5                   10                  15      


Pro Ile Val Ala Phe Ser Ile Asp Asp Glu Gly Glu Ser Ala Gln Phe 
            20                  25                  30          


Arg Thr Trp Val Cys Lys Trp Glu Gln Lys Arg Thr Val Leu Leu Tyr 
        35                  40                  45              


Tyr Ile Arg Val Leu Ile Ala Lys Thr Ala Arg Asp Ala Gly Ala Leu 
    50                  55                  60                  


Arg Gln Gln Arg Ala Ala Phe Phe Glu Ala Trp Ser Asn Ala Val Ser 
65                  70                  75                  80  


Leu Arg Asn Leu Lys Asn Val Ala Lys Lys Val Lys Lys Ala Thr Glu 
                85                  90                  95      


Ala Val Asp Trp Ala Thr Gln Cys Glu Gly Val Met Phe Met Thr Leu 
            100                 105                 110         


Gln Thr Ile Ile Arg Ala Leu Asn Thr Met Arg Gly His Val Ser Asp 
        115                 120                 125             


Lys Asp Gly Thr Ala Pro Ser Asp Cys Gly Leu Glu Pro His Gln Gly 
    130                 135                 140                 


Arg Ala Ala Asp Arg Asn Met Thr Tyr Val Glu Val Ile Glu His Ile 
145                 150                 155                 160 


Lys Ser Thr Glu Arg Arg Leu Gln Glu Leu Ser Met Phe Ala Glu Glu 
                165                 170                 175     


Ser Val Arg Thr Phe Tyr Gly Asn Tyr Val Asn Gly Val Gly Leu Leu 
            180                 185                 190         


Asn Asp Thr Asn Asn Tyr Phe Ala Ala Ala Glu Ala Ala Arg Arg Ala 
        195                 200                 205             


Leu Arg Glu Ala Asp Glu Ala Met Lys Asp Ala Ser Asp Arg Lys Glu 
    210                 215                 220                 


Leu Asn Glu Lys Arg Val Gln Leu Gly Cys Glu Val Glu Lys Gly Leu 
225                 230                 235                 240 


Phe Phe Met Arg Glu Ile Phe Leu Thr Leu His Ser Val Ser Glu Arg 
                245                 250                 255     


Val Ile Ser Arg Glu Arg Ala Leu Lys Ala Lys Val Gly Glu Leu Asp 
            260                 265                 270         


Glu Gly Pro Gly Ala Cys Gly Met Ala His Thr Met Phe Arg Ser Thr 
        275                 280                 285             


Ala Tyr Ala Asn Leu Arg Ala Ser Ser Ala Lys Asp Glu Ser Ser Leu 
    290                 295                 300                 


Ala Val Val Glu Leu Ser Glu Phe Met Gly Ile Lys Gly His Ser Thr 
305                 310                 315                 320 


Leu His His Glu Leu Glu Tyr Asp Asp Asp Phe Lys Ile Ser Leu Thr 
                325                 330                 335     


Asn Cys Arg Asp Ser Glu Leu Glu Gln Ser Leu Val Phe Arg Phe Ala 
            340                 345                 350         


Arg Gly Glu Glu Asn Asp Asn Ile Tyr Asp Phe Asp Arg Trp Arg Ala 
        355                 360                 365             


Ala Ala Asp Glu Leu Trp Asn Lys Val Glu Ser His Thr His Ile Ile 
    370                 375                 380                 


Ser Glu Lys Cys Thr Lys Val Ser Gly Val Asp Cys Ser Glu Ala Val 
385                 390                 395                 400 


Gly Ala Val Thr Met Leu Ile Gly Arg Leu Arg Gln Leu Glu Gly Asp 
                405                 410                 415     


Leu Glu Arg Gly Leu Gly Ala Ala Ile Arg Ala Leu Lys Thr Val Glu 
            420                 425                 430         


Asp Gly Ile Ala Thr Ser Gln Asp Ala Met Arg Lys Cys Gln His Gly 
        435                 440                 445             


Gly Ala Val Asn Glu His His Thr Glu Ala Lys Glu Pro Gln Thr Thr 
    450                 455                 460                 


Ser Gly Arg Arg Glu Ala Asn Thr Asp Ser Ala Pro Ala Lys Glu Gln 
465                 470                 475                 480 


Leu Asp Ala Ala Ser Lys Leu Glu Gly Gly Ser Arg Leu Glu Glu Glu 
                485                 490                 495     


Val Asp Gly Asn Glu Lys Glu Glu Gln Gln Glu Ala Pro Ala Asn Gly 
            500                 505                 510         


Pro Gln Gly Ala Leu Gly Val Arg Gln Glu Glu Thr Ser Tyr Glu Gly 
        515                 520                 525             


Asp Ala Gly Arg Gly Ser Val Asp Thr Gly His Asp Glu Phe Ala Thr 
    530                 535                 540                 


Tyr Leu Ala Ser Arg Ser Ala Cys Ser Thr Ala Gly Asp Gly Ile Glu 
545                 550                 555                 560 


Ser Ser Ser Thr Ala Gly Asp Ala Ala Ala Val Glu Ala Arg Ser Lys 
                565                 570                 575     


Lys Lys Tyr Leu Ala Leu Met Ser Val Leu Cys Phe Leu Phe Val Ser 
            580                 585                 590         


Ala Ala Ser Val Val Leu Leu Ala Trp Lys Arg Thr Lys Leu 
        595                 600                 605     


