                         б

<110>  ＼޹˾
<120>  ѪƤϸһTϸĶںϵ׺Ͱҩ
<130>  
<160>  88    
<170>  PatentIn汾3.3
<210>  1
<211>  116
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеĿVEGFVEGFRɱ
<400>  1
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  
Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         
Trp Gly Gln Gly 
        115     
<210>  2
<211>  101
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеĿVEGFVEGFRɱ
<400>  2
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              
Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      
Thr Phe Gly Gln Gly 
            100     
<210>  3
<211>  116
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеĿVEGFVEGFRɱ
<400>  3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asp Phe Thr His Tyr 
            20                  25                  30          
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  
Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         
Trp Gly Gln Gly 
        115     
<210>  4
<211>  101
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеĿVEGFVEGFRɱ
<400>  4
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              
Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      
Thr Phe Gly Gln Gly 
            100     
<210>  5
<211>  109
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеĿVEGFVEGFRɱ
<400>  5
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Thr Asp Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 
<210>  6
<211>  101
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеĿVEGFVEGFRɱ
<400>  6
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Ile Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asp Asn Trp 
            20                  25                  30          
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Asp Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Tyr Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ala Lys Ala Phe Pro Pro 
                85                  90                  95      
Thr Phe Gly Gly Gly 
            100     
<210>  7
<211>  205
<212>  PRT
<213>  ˹
<220>  
<223>  VEGFR1-D2/VEGFR2-D3
<400>  7
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      
Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          
Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              
Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  
Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  
Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      
Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         
Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             
Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 
His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 
Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     
Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         
Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys 
        195                 200                 205 
<210>  8
<211>  303
<212>  PRT
<213>  ˹
<220>  
<223>  VEGFR1-D2/VEGFR2-D3-D4
<400>  8
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      
Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          
Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              
Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  
Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  
Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      

Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         
Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             
Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 
His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 
Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     
Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         
Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Pro Phe Val 
        195                 200                 205             
Ala Phe Gly Ser Gly Met Glu Ser Leu Val Glu Ala Thr Val Gly Glu 
    210                 215                 220                 
Arg Val Arg Ile Pro Ala Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile 
225                 230                 235                 240 
Lys Trp Tyr Lys Asn Gly Ile Pro Leu Glu Ser Asn His Thr Ile Lys 
                245                 250                 255     
Ala Gly His Val Leu Thr Ile Met Glu Val Ser Glu Arg Asp Thr Gly 
            260                 265                 270         
Asn Tyr Thr Val Ile Leu Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser 
        275                 280                 285             
His Val Val Ser Leu Val Val Tyr Val Pro Pro Gly Pro Gly Asp 
    290                 295                 300             
<210>  9
<211>  100
<212>  PRT
<213>  ˹
<220>  
<223>  VEGFR1-D2
<400>  9
Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      
Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          
Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              
Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  
Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  
Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      
Gln Thr Asn Thr 
            100 
<210>  10
<211>  227
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеIgG1 Fcİ
<400>  10
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 
Pro Gly Lys 
225         
<210>  11
<211>  232
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеIgG2 Fcİ
<400>  11
Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10                  15      
Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  
Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     
Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         
<210>  12
<211>  233
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеIgG4 Fcİ
<400>  12
Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10                  15      
Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    50                  55                  60                  
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
    130                 135                 140                 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         
Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
        195                 200                 205             
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 
Lys Ser Leu Ser Leu Ser Leu Gly Lys 
225                 230             
<210>  13
<211>  112
<212>  PRT
<213>  ˹
<220>  
<223>  CD80-IgV
<400>  13
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         
<210>  14
<211>  208
<212>  PRT
<213>  ˹
<220>  
<223>  CD80-IgVIgC
<400>  14
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         
Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 
Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             
<210>  15
<211>  113
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеĿVEGFVEGFR㶨У
<400>  15
Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
1               5                   10                  15      
Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
            20                  25                  30          
Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
        35                  40                  45              
Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
    50                  55                  60                  
Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
65                  70                  75                  80  
Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
                85                  90                  95      
His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105                 110         
Cys 
    
<210>  16
<211>  112
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеĿVEGFVEGFR㶨У
<400>  16
Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr 
1               5                   10                  15      
Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu 
            20                  25                  30          
Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp 
        35                  40                  45              
Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro 
    50                  55                  60                  
Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu 
65                  70                  75                  80  
Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr 
                85                  90                  95      
His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105                 110         
<210>  17
<211>  337
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеĿ㶨УIgG1
<400>  17
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
1               5                   10                  15      
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
            20                  25                  30          
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        35                  40                  45              
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    50                  55                  60                  
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
65                  70                  75                  80  
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
                85                  90                  95      
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
            100                 105                 110         
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        115                 120                 125             
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    130                 135                 140                 
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
145                 150                 155                 160 
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                165                 170                 175     
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            180                 185                 190         
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        195                 200                 205             
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    210                 215                 220                 
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
225                 230                 235                 240 
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                245                 250                 255     
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            260                 265                 270         
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        275                 280                 285             
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    290                 295                 300                 
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
305                 310                 315                 320 
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 330                 335     
Lys 
    
<210>  18
<211>  333
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеĿ㶨УIgG2
<400>  18
Thr Thr Val Thr Val Ser Thr Ala Ser Thr Lys Gly Pro Ser Val Phe 
1               5                   10                  15      
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
            20                  25                  30          
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        35                  40                  45              
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    50                  55                  60                  
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
65                  70                  75                  80  
Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
                85                  90                  95      
Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
            100                 105                 110         
Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
        115                 120                 125             
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    130                 135                 140                 
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
145                 150                 155                 160 
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                165                 170                 175     
Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
            180                 185                 190         
Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        195                 200                 205             
Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    210                 215                 220                 
Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
225                 230                 235                 240 
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                245                 250                 255     
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            260                 265                 270         
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
        275                 280                 285             
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    290                 295                 300                 
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
305                 310                 315                 320 
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330             
<210>  19
<211>  334
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеĿ㶨УIgG4
<400>  19
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
1               5                   10                  15      
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
            20                  25                  30          
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        35                  40                  45              
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    50                  55                  60                  
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
65                  70                  75                  80  
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
                85                  90                  95      
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
            100                 105                 110         
Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    130                 135                 140                 
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
145                 150                 155                 160 
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                165                 170                 175     
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        195                 200                 205             
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
    210                 215                 220                 
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
225                 230                 235                 240 
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                245                 250                 255     
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            260                 265                 270         
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        275                 280                 285             
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
    290                 295                 300                 
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
305                 310                 315                 320 
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
                325                 330                 
<210>  20
<211>  16
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  20
Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg 
1               5                   10                  15      
<210>  21
<211>  17
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  21
Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg 
1               5                   10                  15      
Val 
    
<210>  22
<211>  9
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  22
Ala Lys Thr Thr Pro Lys Leu Gly Gly 
1               5                   
<210>  23
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  23
Ser Ala Lys Thr Thr Pro Lys Leu Gly Gly 
1               5                   10  
<210>  24
<211>  6
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  24
Ser Ala Lys Thr Thr Pro 
1               5       
<210>  25
<211>  6
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  25
Arg Ala Asp Ala Ala Pro 
1               5       
<210>  26
<211>  9
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  26
Arg Ala Asp Ala Ala Pro Thr Val Ser 
1               5                   
<210>  27
<211>  12
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  27
Arg Ala Asp Ala Ala Ala Ala Gly Gly Pro Gly Ser 
1               5                   10          
<210>  28
<211>  7
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  28
Arg Ala Asp Ala Ala Ala Ala 
1               5           
<210>  29
<211>  18
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  29
Ser Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala 
1               5                   10                  15      
Arg Val 
        
<210>  30
<211>  5
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  30
Ala Asp Ala Ala Pro 
1               5   
<210>  31
<211>  11
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  31
Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
1               5                   10      
<210>  32
<211>  5
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  32
Thr Val Ala Ala Pro 
1               5   
<210>  33
<211>  12
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  33
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10          
<210>  34
<211>  6
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  34
Gln Pro Lys Ala Ala Pro 
1               5       
<210>  35
<211>  13
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  35
Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
1               5                   10              
<210>  36
<211>  6
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  36
Ala Lys Thr Thr Pro Pro 
1               5       
<210>  37
<211>  13
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  37
Ala Lys Thr Thr Pro Pro Ser Val Thr Pro Leu Ala Pro 
1               5                   10              
<210>  38
<211>  6
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  38
Ala Lys Thr Thr Ala Pro 
1               5       
<210>  39
<211>  13
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  39
Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro 
1               5                   10              
<210>  40
<211>  6
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  40
Ala Ser Thr Lys Gly Pro 
1               5       
<210>  41
<211>  13
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  41
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
1               5                   10              
<210>  42
<211>  15
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  42
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  
<210>  43
<211>  15
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  43
Gly Glu Asn Lys Val Glu Tyr Ala Pro Ala Leu Met Ala Leu Ser 
1               5                   10                  15  
<210>  44
<211>  15
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  44
Gly Pro Ala Lys Glu Leu Thr Pro Leu Lys Glu Ala Lys Val Ser 
1               5                   10                  15  
<210>  45
<211>  15
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  45
Gly His Glu Ala Ala Ala Val Met Gln Val Gln Tyr Pro Ala Ser 
1               5                   10                  15  
<210>  46
<211>  16
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ  
<400>  46
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
1               5                   10                  15      
<210>  47
<211>  106
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  47
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly 
            100                 105     
<210>  48
<211>  101
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  48
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      
Thr Phe Gly Gln Gly 
            100     
<210>  49
<211>  113
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  49
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly 
    
<210>  50
<211>  105
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  50
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          
Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      
Asp Leu Pro Leu Thr Phe Gly Gly Gly 
            100                 105 
<210>  51
<211>  110
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  51
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Asp Ser Gly Glu Ser Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  
Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Ile Thr Ser Leu Thr Ala Glu Asp Thr Gly Met Tyr Phe Cys 
                85                  90                  95      
Val Arg Val Gly Tyr Asp Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110 
<210>  52
<211>  100
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  52
Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Cys Leu Thr Ile Asn Ser Leu Gln Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Phe Pro Leu Thr 
                85                  90                  95      
Phe Gly Gly Gly 
            100 
<210>  53
<211>  109
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  53
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Met Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Gly Gly Gly Ala Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gln Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 
<210>  54
<211>  101
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  54
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          
Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Thr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Ser Ile Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly 
            100     
<210>  55
<211>  114
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  55
Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          
Gly Thr Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              
Trp Leu Ala Thr Ile Cys Trp Glu Asp Ser Lys Gly Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Ala 
65                  70                  75                  80  
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Arg Glu Asp Ser Gly Tyr Phe Trp Phe Pro Tyr Trp Gly 
            100                 105                 110         
Gln Gly 
        
<210>  56
<211>  100
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  56
Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Gly Gln Asn Val Asn Asn Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              
Phe Asn Ala Asn Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Trp Thr Thr 
                85                  90                  95      
Phe Gly Gly Gly 
            100 
<210>  57
<211>  111
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  57
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  
Lys Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val Trp Gly Gln Gly 
            100                 105                 110     
<210>  58
<211>  101
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  58
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              
Asn Tyr Ala Phe His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  
Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Ser Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly 
            100     
<210>  59
<211>  105
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  59
Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
1               5                   10                  15      
Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Tyr Gly 
            20                  25                  30          
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              
Val Ile Trp Tyr Asp Ser Ser Arg Lys Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Thr Asn Asn Asp Tyr Trp Gly Gln Gly 
            100                 105 
<210>  60
<211>  101
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  60
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 
            20                  25                  30          
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Thr Arg Ala Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Met Gln Leu Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly 
            100     
<210>  61
<211>  113
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  61
Asp Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
1               5                   10                  15      
Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Gly Ile 
            20                  25                  30          
Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
        35                  40                  45              
Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln Gly 
    50                  55                  60                  
Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
65                  70                  75                  80  
Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      
Gly Arg Gly Tyr Ser Tyr Gly Ile Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         
Gly 
    
<210>  62
<211>  103
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  62
Leu Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly 
1               5                   10                  15      
Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr 
            20                  25                  30          
Ala Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
        35                  40                  45              
Tyr Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
    50                  55                  60                  
Ser Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala 
65                  70                  75                  80  
Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr 
                85                  90                  95      
Tyr Val Val Phe Gly Gly Gly 
            100             
<210>  63
<211>  118
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  63
Gln Gly Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Val Ile Glu Ser Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Glu Gly Ile Thr Thr Val Ala Thr Thr Tyr Tyr Trp Tyr Phe 
            100                 105                 110         
Asp Val Trp Gly Gln Gly 
        115             
<210>  64
<211>  106
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  64
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Leu Thr Phe Gly Gln Gly 
            100                 105     
<210>  65
<211>  111
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  65
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Gly Gly Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gln Leu Asn Tyr Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110     
<210>  66
<211>  105
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  66
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          
Gly Ile Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Thr Ser Ser Asn Lys Asp Thr Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  
Pro Met Glu Ala Glu Asp Thr Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gly Gly 
            100                 105 
<210>  67
<211>  113
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  67
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Leu Ile Ile Pro Met Phe Asp Thr Ala Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Ala Ile Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Glu His Ser Ser Thr Gly Thr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly 
    
<210>  68
<211>  101
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  68
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Ser Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn His Leu Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly 
            100     
<210>  69
<211>  116
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  69
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Val Ser Ala Asp Ser Ile Ser Ser Thr 
            20                  25                  30          
Thr Tyr Tyr Trp Val Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Ser Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Val Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Asn Ser Val Ala Ala Thr Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      
Cys Ala Arg His Leu Gly Tyr Asn Gly Arg Tyr Leu Pro Phe Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly 
        115     
<210>  70
<211>  104
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  70
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Phe Tyr 
            20                  25                  30          
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Glu Leu 
        35                  40                  45              
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Asn Ile 
                85                  90                  95      
Ser Thr Trp Val Phe Gly Gly Gly 
            100                 
<210>  71
<211>  106
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  71
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Thr Cys Lys Ala Ser Gly Leu Thr Phe Ser Ser Ser 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Asn Asp Tyr Trp Gly Gln Gly 
            100                 105     
<210>  72
<211>  101
<212>  PRT
<213>  ˹
<220>  
<223>  ƷеĿPD-1ɱ
<400>  72
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Thr Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Asn Trp Pro Arg 
                85                  90                  95      
Thr Phe Gly Gln Gly 
            100     
<210>  73
<211>  723
<212>  DNA
<213>  ˹
<220>  
<223>  PD1BY18.1BY18.1L
<400>  73
ctcgaggcca ccatggagac cgacacactc ctcctgtggg tgctgctgct gtgggtgcct     60
ggctccactg gcgagattgt gctgacacag tcccccgcta ctctgagcct gagccctggc    120
gagagggcta cactgtcttg cagagcttct cagtccgtgt cttcttacct cgcttggtat    180
cagcagaagc ccggccaggc tccaagactg ctgatctatg acgcttctaa ccgcgctaca    240
ggcattcctg ctaggttcag cggcagcggc tctggcaccg acttcacact cacaattagc    300
tctcttgaac ctgaggactt cgccgtgtac tactgccagc agtctagcaa ctggcctaga    360
acattcggcc agggcactaa ggtggagatt aagagaaccg tggccgcccc cagcgtgttc    420
atcttccctc ccagcgacga gcagctgaag tctggcaccg ccagcgtggt gtgcctgctg    480
aacaacttct acccccgcga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc    540
ggcaacagcc aggagagcgt gaccgagcag gactccaagg acagcaccta cagcctgagc    600
agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgcgaggtg    660
acccaccagg gactgtctag ccccgtgacc aagagcttca accggggcga gtgctaagaa    720
ttc                                                                  723
<210>  74
<211>  234
<212>  PRT
<213>  ˹
<220>  
<223>  PD1BY18.1BY18.1L
<400>  74
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              
Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  

Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser 
            100                 105                 110         
Asn Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 
<210>  75
<211>  1401
<212>  DNA
<213>  ˹
<220>  
<223>  PD1BY18.1BY18.1H
<400>  75
tctagagcca ccatggagac cgacaccctg ctgctgtggg tgctgctcct gtgggtgcct     60
ggctccacag gccaggtgca gctcgtggag tccggcggcg gcgtggtgca gcccggcaga    120
tccctcagac tggactgcaa ggcatccggc attacattct ctaactctgg aatgcactgg    180
gtgagacagg ctcctggcaa gggcctggaa tgggtggccg tgatttggta cgacggctct    240
aagagatact acgctgactc cgtgaagggc cggttcacaa ttagcagaga caactccaag    300
aacactctgt tcctccagat gaacagcctg agagccgagg acaccgctgt gtactactgc    360
gccaccaacg acgactactg gggccagggc accctcgtga cagtgtcttc cgcctccacc    420
aagggccctt ccgtgttccc tctggcccct tgctcccgct ccacctccga gtccaccgcc    480
gccctgggct gcctggtgaa ggactacttc cctgagcctg tgaccgtgtc ctggaactcc    540
ggcgccctga cctccggcgt gcacaccttc cctgccgtgc tgcagtcctc cggcctgtac    600
tccctgtcct ccgtggtgac cgtgccttcc tcctccctgg gcaccaagac ctacacctgc    660
aacgtggacc acaagccttc caacaccaag gtggacaagc gcgtggagtc caagtacggc    720
cctccttgcc ctccttgccc tgcccctgag ttcctgggcg gcccttccgt gttcctgttc    780
cctcctaagc ctaaggacac cctgatgatc tcccgcaccc ctgaggtgac ctgcgtggtg    840
gtggacgtgt cccaggagga ccctgaggtg cagttcaact ggtacgtgga cggcgtggag    900
gtgcacaacg ccaagaccaa gcctcgcgag gagcagttca actccaccta ccgcgtggtg    960
tccgtgctga ccgtgctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtg   1020
tccaacaagg gcctgccttc ctccatcgag aagaccatct ccaaggccaa gggccagcct   1080
cgcgagcctc aggtgtacac cctgcctcct tcccaggagg agatgaccaa gaaccaggtg   1140
tccctgacct gcctggtgaa gggcttctac ccttccgaca tcgccgtgga gtgggagtcc   1200
aacggccagc ctgagaacaa ctacaagacc acccctcctg tgctggactc cgacggctcc   1260
ttcttcctgt actcccgcct gaccgtggac aagtcccgct ggcaggaggg caacgtgttc   1320
tcctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgtccctg   1380
tccctgggca agtaagtcga c                                             1401
<210>  76
<211>  460
<212>  PRT
<213>  ˹
<220>  
<223>  PD1BY18.1BY18.1H
<400>  76
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr 
        35                  40                  45              
Phe Ser Asn Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr 
65                  70                  75                  80  
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      
Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         
Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 
Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             
Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 
Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
225                 230                 235                 240 
Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         
Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
        275                 280                 285             
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 
Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     
Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
        355                 360                 365             
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     
Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
            420                 425                 430         
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460 
<210>  77
<211>  1113
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY31.19 CD80-FcIgG4ĺ
<400>  77
ctcgaggcca ccatggagac cgacacactc ctcctgtggg tgctgctgct gtgggtgcct     60
ggctccactg gcgtcatcca tgtgaccaaa gaggtcaaag aagtcgcaac tctgtcttgc    120
ggacacaacg tctccgtcga agaactcgcc cagactagaa tatattggca gaaggaaaag    180
aagatggtgc tcaccatgat gtccggcgat atgaacattt ggcctgagta caagaaccgg    240
acaatcttcg atattactaa taacctgagt atcgtgattc tcgctctgcg ccctagcgac    300
gagggcacat acgagtgtgt ggtgctgaag tacgagaagg atgcattcaa gcgggagcac    360
ctcgcagagg tgacactctc cgtgaaggcc gacttcccaa ccccatctga caagcgcgtg    420
gagtccaagt acggccctcc ttgccctcct tgccctgccc ctgagttcct gggcggccct    480
tccgtgttcc tgttccctcc taagcctaag gacaccctga tgatctcccg cacccctgag    540
gtgacctgcg tggtggtgga cgtgtcccag gaggaccctg aggtgcagtt caactggtac    600
gtggacggcg tggaggtgca caacgccaag accaagcctc gcgaggagca gttcaactcc    660
acctaccgcg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag    720
tacaagtgca aggtgtccaa caagggcctg ccttcctcca tcgagaagac catctccaag    780
gccaagggcc agcctcgcga gcctcaggtg tacaccctgc ctccttccca ggaggagatg    840
accaagaacc aggtgtccct gacctgcctg gtgaagggct tctacccttc cgacatcgcc    900
gtggagtggg agtccaacgg ccagcctgag aacaactaca agaccacccc tcctgtgctg    960
gactccgacg gctccttctt cctgtactcc cgcctgaccg tggacaagtc ccgctggcag   1020
gagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag   1080
aagtccctgt ccctgtccct gggctaagaa ttc                                1113
<210>  78
<211>  364
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY31.19CD80-FcIgG4İ
<400>  78
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala 
            20                  25                  30          
Thr Leu Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr 
        35                  40                  45              
Arg Ile Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser 
    50                  55                  60                  
Gly Asp Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp 
65                  70                  75                  80  
Ile Thr Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp 
                85                  90                  95      
Glu Gly Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe 
            100                 105                 110         
Lys Arg Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe 
        115                 120                 125             
Pro Thr Pro Ser Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    130                 135                 140                 
Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
145                 150                 155                 160 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     
Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            180                 185                 190         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             
Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 
Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         
Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     
Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        355                 360                 
<210>  79
<211>  723
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY24.4,IgG4ĵһǻBY24.4L
<400>  79
ctcgaggcca ccatggagac agatactctg ctgctctggg tcctgctgct gtgggtgcca     60
ggcagcacag gcgacatcca gatgacccag tccccttcct ccctgtctgc ctccgtgggc    120
gacagggtga ccatcacctg ttccgcatcc caggatatct ccaactacct gaactggtat    180
cagcagaagc caggaaaggc ccccaaggtg ctgatctact ttacttcttc cctgcattcc    240
ggcgtgccct ccaggttctc tggctccggg tctggaaccg actttacact gacaatctcc    300
tctctgcagc cagaagactt tgccacctat tactgccagc agtactccac tgtcccctgg    360
accttcgggc aaggaaccaa agtggaaatc aagaggaccg tggccgcccc cagcgtgttc    420
atcttccctc ccagcgacga gcagctgaag tctggcaccg ccagcgtggt gtgcctgctg    480
aacaacttct acccccgcga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc    540
ggcaacagcc aggagagcgt gaccgagcag gactccaagg acagcaccta cagcctgagc    600
agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgcgaggtg    660
acccaccagg gactgtctag ccccgtgacc aagagcttca accggggcga gtgctaagaa    720
ttc                                                                  723
<210>  80
<211>  234
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY24.4,IgG4ĵһǻBY24.4L
<400>  80
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp 
        35                  40                  45              
Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  
Lys Val Leu Ile Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser 
            100                 105                 110         
Thr Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 
<210>  81
<211>  1806
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY24.4,IgG4ĵڶǻBY24.4H
<400>  81
tctagagcca ccatggaaac cgacacactg ctgctgtggg tcctgctgct gtgggtgcca     60
ggctctacag gcgaagtgca gctggtcgaa tctggcggcg gactggtgca accagggggc    120
agcctgaggc tgtcctgcgc cgcttctgga tacaccttta ccaattacgg catgaattgg    180
gtgaggcagg ctcctggcaa gggcctggag tgggtgggat ggatcaacac ctacaccggc    240
gagcccacct acgccgctga ctttaagagg aggttcacct tctctctgga cacctccaag    300
tccaccgctt acctgcaaat gaactctctg agggctgaag acaccgccgt gtactactgc    360
gccaagtacc cccattacta cgggtcctcc cactggtact tcgacgtgtg gggccagggc    420
accctcgtga cagtgtcttc cgcctccacc aagggccctt ccgtgttccc tctggcccct    480
tgctcccgct ccacctccga gtccaccgcc gccctgggct gcctggtgaa ggactacttc    540
cctgagcctg tgaccgtgtc ctggaactcc ggcgccctga cctccggcgt gcacaccttc    600
cctgccgtgc tgcagtcctc cggcctgtac tccctgtcct ccgtggtgac cgtgccttcc    660
tcctccctgg gcaccaagac ctacacctgc aacgtggacc acaagccttc caacaccaag    720
gtggacaagc gcgtggagtc caagtacggc cctccttgcc ctccttgccc tgcccctgag    780
ttcctgggcg gcccttccgt gttcctgttc cctcctaagc ctaaggacac cctgatgatc    840
tcccgcaccc ctgaggtgac ctgcgtggtg gtggacgtgt cccaggagga ccctgaggtg    900
cagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcctcgcgag    960
gagcagttca actccaccta ccgcgtggtg tccgtgctga ccgtgctgca ccaggactgg   1020
ctgaacggca aggagtacaa gtgcaaggtg tccaacaagg gcctgccttc ctccatcgag   1080
aagaccatct ccaaggccaa gggccagcct cgcgagcctc aggtgtacac cctgcctcct   1140
tcccaggagg agatgaccaa gaaccaggtg tccctgacct gcctggtgaa gggcttctac   1200
ccttccgaca tcgccgtgga gtgggagtcc aacggccagc ctgagaacaa ctacaagacc   1260
acccctcctg tgctggactc cgacggctcc ttcttcctgt actcccgcct gaccgtggac   1320
aagtcccgct ggcaggaggg caacgtgttc tcctgctccg tgatgcacga ggccctgcac   1380
aaccactaca cccagaagtc cctgtccctg tccctgggcg gcggaggatc tggcggcgga   1440
ggcagtggag gcggcggaag tgtgatccat gtaacaaaag aagtgaagga agtggctaca   1500
ctctcttgcg gccacaacgt gtccgtggag gaactagctc agacccggat ctattggcag   1560
aaagaaaaga agatggtgct gaccatgatg tccggcgaca tgaacatttg gccagagtac   1620
aagaaccgca caattttcga cattacaaac aacctctcta ttgtgattct ggctctcagg   1680
cctagcgacg agggcacata cgagtgcgtg gtgctcaagt acgagaagga cgctttcaag   1740
cgggagcacc tcgctgaggt gaccctgtcc gtgaaggccg acttccctac tccatcttaa   1800
gtcgac                                                              1806
<210>  82
<211>  595
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY24.4,IgG4ĵڶǻBY24.4H
<400>  82
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr 
        35                  40                  45              
Phe Thr Asn Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Val Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr 
65                  70                  75                  80  
Ala Ala Asp Phe Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys 
                85                  90                  95      
Ser Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         
Val Tyr Tyr Cys Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp 
        115                 120                 125             
Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
145                 150                 155                 160 
Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr 
    210                 215                 220                 
Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
225                 230                 235                 240 
Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     
Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             
Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
305                 310                 315                 320 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
            340                 345                 350         
Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             
Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
    370                 375                 380                 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
            420                 425                 430         
Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
        435                 440                 445             
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 
Ser Leu Ser Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
465                 470                 475                 480 
Gly Gly Ser Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr 
                485                 490                 495     
Leu Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg 
            500                 505                 510         
Ile Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly 
        515                 520                 525             
Asp Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile 
    530                 535                 540                 
Thr Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu 
545                 550                 555                 560 
Gly Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys 
                565                 570                 575     
Arg Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro 
            580                 585                 590         
Thr Pro Ser 
        595 
<210>  83
<211>  723
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY24.5,IgG4ĵһǻBY24.5L
<400>  83
ctcgaggcca ccatggagac agatactctg ctgctctggg tcctgctgct gtgggtgcca     60
ggcagcacag gcgacatcca gatgacccag tctcctagct ccgtgagcgc ctctatcggc    120
gacagagtga ccatcacatg cagagcttct cagggcatcg acaactggct cggctggtac    180
cagcagaagc ctggcaaggc cccaaagctg ctgatctacg acgcctctaa cctggacacc    240
ggcgtgccat cccggttcag cggctctggc tccggcacat acttcacact cacaatctct    300
tccctgcagg ccgaggactt cgctgtgtac ttctgccagc aggctaaggc tttcccacct    360
acattcggcg gcggaaccaa agtggaaatc aagaggaccg tggccgcccc cagcgtgttc    420
atcttccctc ccagcgacga gcagctgaag tctggcaccg ccagcgtggt gtgcctgctg    480
aacaacttct acccccgcga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc    540
ggcaacagcc aggagagcgt gaccgagcag gactccaagg acagcaccta cagcctgagc    600
agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgcgaggtg    660
acccaccagg gactgtctag ccccgtgacc aagagcttca accggggcga gtgctaagaa    720
ttc                                                                  723
<210>  84
<211>  234
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY24.5,IgG4ĵһǻBY24.5L
<400>  84
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser 
            20                  25                  30          
Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              
Ile Asp Asn Trp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  
Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Asp Thr Gly Val Pro Ser 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Thr Ile Ser 
                85                  90                  95      
Ser Leu Gln Ala Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ala Lys 
            100                 105                 110         
Ala Phe Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 
<210>  85
<211>  1785
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY24.5,IgG4ĵڶǻBY24.5H
<400>  85
tctagagcca ccatggaaac cgacacactg ctgctgtggg tcctgctgct gtgggtgcca     60
ggctctacag gcgaggtgca gctcgtgcag tctggcggcg gcctcgtgaa gccaggcggc    120
tccctcagac tgtcttgcgc tgctagcggc ttcacattct cttcctactc tatgaactgg    180
gtgagacagg ctcccggcaa gggcctggag tgggtgtcca gcatctcttc ctctagctct    240
tacatctact acgccgactc cgtgaagggc agattcacaa tcagccggga caacgccaag    300
aactccctgt acctgcagat gaacagcctg agagccgagg acaccgctgt gtactactgc    360
gctagagtga ccgacgcttt cgacatctgg ggccagggca ctctcgtgac agtgtcttcc    420
gcctccacca agggcccttc cgtgttccct ctggcccctt gctcccgctc cacctccgag    480
tccaccgccg ccctgggctg cctggtgaag gactacttcc ctgagcctgt gaccgtgtcc    540
tggaactccg gcgccctgac ctccggcgtg cacaccttcc ctgccgtgct gcagtcctcc    600
ggcctgtact ccctgtcctc cgtggtgacc gtgccttcct cctccctggg caccaagacc    660
tacacctgca acgtggacca caagccttcc aacaccaagg tggacaagcg cgtggagtcc    720
aagtacggcc ctccttgccc tccttgccct gcccctgagt tcctgggcgg cccttccgtg    780
ttcctgttcc ctcctaagcc taaggacacc ctgatgatct cccgcacccc tgaggtgacc    840
tgcgtggtgg tggacgtgtc ccaggaggac cctgaggtgc agttcaactg gtacgtggac    900
ggcgtggagg tgcacaacgc caagaccaag cctcgcgagg agcagttcaa ctccacctac    960
cgcgtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa ggagtacaag   1020
tgcaaggtgt ccaacaaggg cctgccttcc tccatcgaga agaccatctc caaggccaag   1080
ggccagcctc gcgagcctca ggtgtacacc ctgcctcctt cccaggagga gatgaccaag   1140
aaccaggtgt ccctgacctg cctggtgaag ggcttctacc cttccgacat cgccgtggag   1200
tgggagtcca acggccagcc tgagaacaac tacaagacca cccctcctgt gctggactcc   1260
gacggctcct tcttcctgta ctcccgcctg accgtggaca agtcccgctg gcaggagggc   1320
aacgtgttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc   1380
ctgtccctgt ccctgggcgg cggaggatct ggcggcggag gcagtggagg cggcggaagt   1440
gtgatccatg taacaaaaga agtgaaggaa gtggctacac tctcttgcgg ccacaacgtg   1500
tccgtggagg aactagctca gacccggatc tattggcaga aagaaaagaa gatggtgctg   1560
accatgatgt ccggcgacat gaacatttgg ccagagtaca agaaccgcac aattttcgac   1620
attacaaaca acctctctat tgtgattctg gctctcaggc ctagcgacga gggcacatac   1680
gagtgcgtgg tgctcaagta cgagaaggac gctttcaagc gggagcacct cgctgaggtg   1740
accctgtccg tgaaggccga cttccctact ccatcttaag tcgac                   1785
<210>  86
<211>  588
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY24.5,IgG4ĵڶǻBY24.5H
<400>  86
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val 
            20                  25                  30          
Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              
Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Val Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr 
65                  70                  75                  80  
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      
Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Val Thr Asp Ala Phe Asp Ile Trp Gly Gln 
        115                 120                 125             
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 
Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
145                 150                 155                 160 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             
Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
    210                 215                 220                 
Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
225                 230                 235                 240 
Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
                245                 250                 255     
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
        275                 280                 285             
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     
Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
            340                 345                 350         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             
Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     
Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         
Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 
    450                 455                 460                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Ile His Val 
465                 470                 475                 480 
Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys Gly His Asn Val 
                485                 490                 495     
Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp Gln Lys Glu Lys 
            500                 505                 510         
Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn Ile Trp Pro Glu 
        515                 520                 525             
Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn Leu Ser Ile Val 
    530                 535                 540                 
Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr Glu Cys Val Val 
545                 550                 555                 560 
Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His Leu Ala Glu Val 
                565                 570                 575     
Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            580                 585             
<210>  87
<211>  1776
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY24.12CD80-Fc-VEGFRĺ
<400>  87
ctcgaggcca ccgccaccat ggagaccgac acactcctcc tgtgggtgct gctgctgtgg     60
gtgcctggct ccactggcgt catccatgtg accaaagagg tcaaagaagt cgcaactctg    120
tcttgcggac acaacgtctc cgtcgaagaa ctcgcccaga ctagaatata ttggcagaag    180
gaaaagaaga tggtgctcac catgatgtcc ggcgatatga acatttggcc tgagtacaag    240
aaccggacaa tcttcgatat tactaataac ctgagtatcg tgattctcgc tctgcgccct    300
agcgacgagg gcacatacga gtgtgtggtg ctgaagtacg agaaggatgc attcaagcgg    360
gagcacctcg cagaggtgac actctccgtg aaggccgact tcccaacccc atctgacaag    420
cgcgtggagt ccaagtacgg ccctccttgc cctccttgcc ctgcccctga gttcctgggc    480
ggcccttccg tgttcctgtt ccctcctaag cctaaggaca ccctgatgat ctcccgcacc    540
cctgaggtga cctgcgtggt ggtggacgtg tcccaggagg accctgaggt gcagttcaac    600
tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcctcgcga ggagcagttc    660
aactccacct accgcgtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc    720
aaggagtaca agtgcaaggt gtccaacaag ggcctgcctt cctccatcga gaagaccatc    780
tccaaggcca agggccagcc tcgcgagcct caggtgtaca ccctgcctcc ttcccaggag    840
gagatgacca agaaccaggt gtccctgacc tgcctggtga agggcttcta cccttccgac    900
atcgccgtgg agtgggagtc caacggccag cctgagaaca actacaagac cacccctcct    960
gtgctggact ccgacggctc cttcttcctg tactcccgcc tgaccgtgga caagtcccgc   1020
tggcaggagg gcaacgtgtt ctcctgctcc gtgatgcacg aggccctgca caaccactac   1080
acccagaagt ccctgtccct gtccctgggc ggcggaggat ctggcggcgg aggcagtgga   1140
ggcggcggaa gtgcttccga caccggccgc cctttcgtgg agatgtactc cgagatccct   1200
gagatcatcc acatgaccga gggccgcgag ctggtgatcc cttgccgcgt gacctcccct   1260
aacatcaccg tgaccctgaa gaagttccct ctggacaccc tgatccctga cggcaagcgc   1320
atcatctggg actcccgcaa gggcttcatc atctccaacg ccacctacaa ggagatcggc   1380
ctgctgacct gcgaggccac cgtgaacggc cacctgtaca agaccaacta cctgacccac   1440
cgccagacca acaccatcat cgacgtggtg ctgtcccctt cccacggcat cgagctgtcc   1500
gtgggcgaga agctggtgct gaactgcacc gcccgcaccg agctgaacgt gggcatcgac   1560
ttcaactggg agtacccttc ctccaagcac cagcacaaga agctggtgaa ccgcgacctg   1620
aagacccagt ccggctccga gatgaagaag ttcctgtcca ccctgaccat cgacggcgtg   1680
acccgctccg accagggcct gtacacctgc gccgcctcct ccggcctgat gaccaagaag   1740
aactccacct tcgtgcgcgt gcacgagtaa gaattc                             1776
<210>  88
<211>  583
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY24.12CD80-Fc-VEGFRİ
<400>  88
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala 
            20                  25                  30          
Thr Leu Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr 
        35                  40                  45              
Arg Ile Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser 
    50                  55                  60                  
Gly Asp Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp 
65                  70                  75                  80  
Ile Thr Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp 
                85                  90                  95      
Glu Gly Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe 
            100                 105                 110         
Lys Arg Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe 
        115                 120                 125             
Pro Thr Pro Ser Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    130                 135                 140                 
Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
145                 150                 155                 160 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     
Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            180                 185                 190         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             
Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 
Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         
Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     
Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser 
        355                 360                 365             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Asp Thr Gly Arg 
    370                 375                 380                 
Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile His Met Thr 
385                 390                 395                 400 
Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser Pro Asn Ile 
                405                 410                 415     
Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly 
            420                 425                 430         
Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala 
        435                 440                 445             
Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly 
    450                 455                 460                 
His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr Asn Thr Ile 
465                 470                 475                 480 
Ile Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly 
                485                 490                 495     
Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly 
            500                 505                 510         
Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys 
        515                 520                 525             
Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys 
    530                 535                 540                 
Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly 
545                 550                 555                 560 
Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser 
                565                 570                 575     
Thr Phe Val Arg Val His Glu 
            580             
