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<110>  Celluris GmbH
       Celluris Participaes Ltda
 
<120>  BISPECIFIC IN TANDEM RECEPTOR CAR AND METHOD FOR MODULATING THE 
       TUMORAL MICROENVIRONMENT

<130>  201890359

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  849
<212>  PRT
<213>  Model 1 - Anti-CD33 - IgG4 (Hinge-CH2CH3) - IL1R2 (extracellular) - CD8 (Hinge)

<400>  1

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu 
145                 150                 155                 160 


Asp Asn Tyr Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Thr Lys Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Val Lys Arg Thr Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys 
                245                 250                 255     


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Phe Thr Leu Gln Pro Ala 
465                 470                 475                 480 


Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly Arg His Tyr 
                485                 490                 495     


Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu Arg Cys Pro 
            500                 505                 510         


Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg Ile Asn Leu 
        515                 520                 525             


Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly Glu Glu Glu 
    530                 535                 540                 


Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu Pro Ala Leu 
545                 550                 555                 560 


Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn Ala Ser Tyr 
                565                 570                 575     


Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn Thr Asp Ala 
            580                 585                 590         


Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu Ser Thr Ser 
        595                 600                 605             


Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg Asp Lys Thr 
    610                 615                 620                 


Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu Asp Lys Asp 
625                 630                 635                 640 


Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu Leu Val His 
                645                 650                 655     


Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val Leu Thr Phe 
            660                 665                 670         


Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile Glu Leu Arg 
        675                 680                 685             


Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile Ser Pro Leu 
    690                 695                 700                 


Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile Pro Cys Lys 
705                 710                 715                 720 


Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu Trp Trp Thr 
                725                 730                 735     


Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly Arg Val Thr 
            740                 745                 750         


Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn Tyr Ile Glu 
        755                 760                 765             


Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu His Met Asp 
    770                 775                 780                 


Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr Leu Arg Thr 
785                 790                 795                 800 


Thr Val Lys Glu Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                805                 810                 815     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            820                 825                 830         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        835                 840                 845             


Asp 
    


<210>  2
<211>  632
<212>  PRT
<213>  Model 2 - Anti-CD33 - IgG4 (Hinge) - IL1R2 (extracellular) - CD8 (Hinge)

<400>  2

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu 
145                 150                 155                 160 


Asp Asn Tyr Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Thr Lys Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Val Lys Arg Thr Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys 
                245                 250                 255     


Pro Phe Thr Leu Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys 
            260                 265                 270         


Arg Phe Arg Gly Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu 
        275                 280                 285             


Pro Val Ala Leu Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser 
    290                 295                 300                 


Val Ser Pro Arg Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg 
305                 310                 315                 320 


Thr Val Pro Gly Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala 
                325                 330                 335     


Leu Trp Leu Leu Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys 
            340                 345                 350         


Thr Thr Arg Asn Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg 
        355                 360                 365             


Val Phe Glu Asn Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln 
    370                 375                 380                 


Ile Leu Thr Leu Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser 
385                 390                 395                 400 


Glu Phe Thr Arg Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp 
                405                 410                 415     


Ser Leu Leu Leu Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly 
            420                 425                 430         


Thr Thr His Leu Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr 
        435                 440                 445             


Tyr Arg Cys Val Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile 
    450                 455                 460                 


Thr Arg Ser Ile Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile 
465                 470                 475                 480 


Pro Val Ile Ile Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser 
                485                 490                 495     


Arg Leu Thr Ile Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu 
            500                 505                 510         


Thr Thr Met Leu Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala 
        515                 520                 525             


Tyr Pro Gly Gly Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu 
    530                 535                 540                 


Asn Asn Glu Asn Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr 
545                 550                 555                 560 


Arg Glu Asp Leu His Met Asp Phe Lys Cys Val Val His Asn Thr Leu 
                565                 570                 575     


Ser Phe Gln Thr Leu Arg Thr Thr Val Lys Glu Thr Thr Thr Pro Ala 
            580                 585                 590         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        595                 600                 605             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    610                 615                 620                 


Arg Gly Leu Asp Phe Ala Cys Asp 
625                 630         


<210>  3
<211>  837
<212>  PRT
<213>  Model 3 - Anti-CD33 - IgG4 (CH2CH3) - IL1R2 (extracellular) - CD8 (Hinge)

<400>  3

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu 
145                 150                 155                 160 


Asp Asn Tyr Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Thr Lys Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Val Lys Arg Thr Val Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        275                 280                 285             


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Phe Thr 
    450                 455                 460                 


Leu Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg 
465                 470                 475                 480 


Gly Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala 
                485                 490                 495     


Leu Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro 
            500                 505                 510         


Arg Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro 
        515                 520                 525             


Gly Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu 
    530                 535                 540                 


Leu Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg 
545                 550                 555                 560 


Asn Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu 
                565                 570                 575     


Asn Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr 
            580                 585                 590         


Leu Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr 
        595                 600                 605             


Arg Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu 
    610                 615                 620                 


Leu Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His 
625                 630                 635                 640 


Leu Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys 
                645                 650                 655     


Val Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser 
            660                 665                 670         


Ile Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile 
        675                 680                 685             


Ile Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr 
    690                 695                 700                 


Ile Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met 
705                 710                 715                 720 


Leu Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly 
                725                 730                 735     


Gly Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu 
            740                 745                 750         


Asn Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp 
        755                 760                 765             


Leu His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln 
    770                 775                 780                 


Thr Leu Arg Thr Thr Val Lys Glu Thr Thr Thr Pro Ala Pro Arg Pro 
785                 790                 795                 800 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                805                 810                 815     


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            820                 825                 830         


Asp Phe Ala Cys Asp 
        835         


<210>  4
<211>  804
<212>  PRT
<213>  Model 4 - Anti-CD33 - IgG4 (Hinge-CH2CH3) - IL1R2 (extracellular)

<400>  4

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu 
145                 150                 155                 160 


Asp Asn Tyr Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Thr Lys Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Val Lys Arg Thr Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys 
                245                 250                 255     


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Phe Thr Leu Gln Pro Ala 
465                 470                 475                 480 


Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly Arg His Tyr 
                485                 490                 495     


Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu Arg Cys Pro 
            500                 505                 510         


Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg Ile Asn Leu 
        515                 520                 525             


Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly Glu Glu Glu 
    530                 535                 540                 


Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu Pro Ala Leu 
545                 550                 555                 560 


Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn Ala Ser Tyr 
                565                 570                 575     


Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn Thr Asp Ala 
            580                 585                 590         


Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu Ser Thr Ser 
        595                 600                 605             


Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg Asp Lys Thr 
    610                 615                 620                 


Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu Asp Lys Asp 
625                 630                 635                 640 


Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu Leu Val His 
                645                 650                 655     


Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val Leu Thr Phe 
            660                 665                 670         


Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile Glu Leu Arg 
        675                 680                 685             


Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile Ser Pro Leu 
    690                 695                 700                 


Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile Pro Cys Lys 
705                 710                 715                 720 


Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu Trp Trp Thr 
                725                 730                 735     


Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly Arg Val Thr 
            740                 745                 750         


Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn Tyr Ile Glu 
        755                 760                 765             


Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu His Met Asp 
    770                 775                 780                 


Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr Leu Arg Thr 
785                 790                 795                 800 


Thr Val Lys Glu 
                


<210>  5
<211>  587
<212>  PRT
<213>  Model 5 - Anti-CD33 - IgG4 (Hinge) - IL1R2 (extracellular)

<400>  5

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu 
145                 150                 155                 160 


Asp Asn Tyr Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Thr Lys Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Val Lys Arg Thr Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys 
                245                 250                 255     


Pro Phe Thr Leu Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys 
            260                 265                 270         


Arg Phe Arg Gly Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu 
        275                 280                 285             


Pro Val Ala Leu Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser 
    290                 295                 300                 


Val Ser Pro Arg Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg 
305                 310                 315                 320 


Thr Val Pro Gly Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala 
                325                 330                 335     


Leu Trp Leu Leu Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys 
            340                 345                 350         


Thr Thr Arg Asn Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg 
        355                 360                 365             


Val Phe Glu Asn Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln 
    370                 375                 380                 


Ile Leu Thr Leu Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser 
385                 390                 395                 400 


Glu Phe Thr Arg Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp 
                405                 410                 415     


Ser Leu Leu Leu Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly 
            420                 425                 430         


Thr Thr His Leu Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr 
        435                 440                 445             


Tyr Arg Cys Val Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile 
    450                 455                 460                 


Thr Arg Ser Ile Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile 
465                 470                 475                 480 


Pro Val Ile Ile Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser 
                485                 490                 495     


Arg Leu Thr Ile Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu 
            500                 505                 510         


Thr Thr Met Leu Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala 
        515                 520                 525             


Tyr Pro Gly Gly Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu 
    530                 535                 540                 


Asn Asn Glu Asn Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr 
545                 550                 555                 560 


Arg Glu Asp Leu His Met Asp Phe Lys Cys Val Val His Asn Thr Leu 
                565                 570                 575     


Ser Phe Gln Thr Leu Arg Thr Thr Val Lys Glu 
            580                 585         


<210>  6
<211>  792
<212>  PRT
<213>  Model 6 - Anti-CD33 - IgG4 (CH2CH3) - IL1R2 (extracellular)

<400>  6

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu 
145                 150                 155                 160 


Asp Asn Tyr Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Thr Lys Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Val Lys Arg Thr Val Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        275                 280                 285             


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Phe Thr 
    450                 455                 460                 


Leu Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg 
465                 470                 475                 480 


Gly Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala 
                485                 490                 495     


Leu Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro 
            500                 505                 510         


Arg Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro 
        515                 520                 525             


Gly Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu 
    530                 535                 540                 


Leu Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg 
545                 550                 555                 560 


Asn Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu 
                565                 570                 575     


Asn Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr 
            580                 585                 590         


Leu Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr 
        595                 600                 605             


Arg Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu 
    610                 615                 620                 


Leu Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His 
625                 630                 635                 640 


Leu Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys 
                645                 650                 655     


Val Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser 
            660                 665                 670         


Ile Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile 
        675                 680                 685             


Ile Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr 
    690                 695                 700                 


Ile Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met 
705                 710                 715                 720 


Leu Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly 
                725                 730                 735     


Gly Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu 
            740                 745                 750         


Asn Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp 
        755                 760                 765             


Leu His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln 
    770                 775                 780                 


Thr Leu Arg Thr Thr Val Lys Glu 
785                 790         


<210>  7
<211>  853
<212>  PRT
<213>  Model 7 - Anti-CD123 - IgG4 (Hinge-CH2CH3) - IL1R2 (extracellular) - CD8 (Hinge)

<400>  7

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Lys Trp Ala Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp 
    130                 135                 140                 


Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Glu Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Pro Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Leu Glu Ile Lys Arg Glu Ser Lys Tyr Gly Pro Pro 
                245                 250                 255     


Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Phe Thr 
465                 470                 475                 480 


Leu Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg 
                485                 490                 495     


Gly Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala 
            500                 505                 510         


Leu Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro 
        515                 520                 525             


Arg Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro 
    530                 535                 540                 


Gly Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu 
545                 550                 555                 560 


Leu Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg 
                565                 570                 575     


Asn Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu 
            580                 585                 590         


Asn Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr 
        595                 600                 605             


Leu Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr 
    610                 615                 620                 


Arg Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu 
625                 630                 635                 640 


Leu Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His 
                645                 650                 655     


Leu Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys 
            660                 665                 670         


Val Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser 
        675                 680                 685             


Ile Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile 
    690                 695                 700                 


Ile Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr 
705                 710                 715                 720 


Ile Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met 
                725                 730                 735     


Leu Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly 
            740                 745                 750         


Gly Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu 
        755                 760                 765             


Asn Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp 
    770                 775                 780                 


Leu His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln 
785                 790                 795                 800 


Thr Leu Arg Thr Thr Val Lys Glu Thr Thr Thr Pro Ala Pro Arg Pro 
                805                 810                 815     


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            820                 825                 830         


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        835                 840                 845             


Asp Phe Ala Cys Asp 
    850             


<210>  8
<211>  636
<212>  PRT
<213>  Model 8 - Anti-CD123 - IgG4 (Hinge) - IL1R2 (extracellular) - CD8 (Hinge)

<400>  8

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Lys Trp Ala Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp 
    130                 135                 140                 


Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Glu Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Pro Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Leu Glu Ile Lys Arg Glu Ser Lys Tyr Gly Pro Pro 
                245                 250                 255     


Cys Pro Ser Cys Pro Phe Thr Leu Gln Pro Ala Ala His Thr Gly Ala 
            260                 265                 270         


Ala Arg Ser Cys Arg Phe Arg Gly Arg His Tyr Lys Arg Glu Phe Arg 
        275                 280                 285             


Leu Glu Gly Glu Pro Val Ala Leu Arg Cys Pro Gln Val Pro Tyr Trp 
    290                 295                 300                 


Leu Trp Ala Ser Val Ser Pro Arg Ile Asn Leu Thr Trp His Lys Asn 
305                 310                 315                 320 


Asp Ser Ala Arg Thr Val Pro Gly Glu Glu Glu Thr Arg Met Trp Ala 
                325                 330                 335     


Gln Asp Gly Ala Leu Trp Leu Leu Pro Ala Leu Gln Glu Asp Ser Gly 
            340                 345                 350         


Thr Tyr Val Cys Thr Thr Arg Asn Ala Ser Tyr Cys Asp Lys Met Ser 
        355                 360                 365             


Ile Glu Leu Arg Val Phe Glu Asn Thr Asp Ala Phe Leu Pro Phe Ile 
    370                 375                 380                 


Ser Tyr Pro Gln Ile Leu Thr Leu Ser Thr Ser Gly Val Leu Val Cys 
385                 390                 395                 400 


Pro Asp Leu Ser Glu Phe Thr Arg Asp Lys Thr Asp Val Lys Ile Gln 
                405                 410                 415     


Trp Tyr Lys Asp Ser Leu Leu Leu Asp Lys Asp Asn Glu Lys Phe Leu 
            420                 425                 430         


Ser Val Arg Gly Thr Thr His Leu Leu Val His Asp Val Ala Leu Glu 
        435                 440                 445             


Asp Ala Gly Tyr Tyr Arg Cys Val Leu Thr Phe Ala His Glu Gly Gln 
    450                 455                 460                 


Gln Tyr Asn Ile Thr Arg Ser Ile Glu Leu Arg Ile Lys Lys Lys Lys 
465                 470                 475                 480 


Glu Glu Thr Ile Pro Val Ile Ile Ser Pro Leu Lys Thr Ile Ser Ala 
                485                 490                 495     


Ser Leu Gly Ser Arg Leu Thr Ile Pro Cys Lys Val Phe Leu Gly Thr 
            500                 505                 510         


Gly Thr Pro Leu Thr Thr Met Leu Trp Trp Thr Ala Asn Asp Thr His 
        515                 520                 525             


Ile Glu Ser Ala Tyr Pro Gly Gly Arg Val Thr Glu Gly Pro Arg Gln 
    530                 535                 540                 


Glu Tyr Ser Glu Asn Asn Glu Asn Tyr Ile Glu Val Pro Leu Ile Phe 
545                 550                 555                 560 


Asp Pro Val Thr Arg Glu Asp Leu His Met Asp Phe Lys Cys Val Val 
                565                 570                 575     


His Asn Thr Leu Ser Phe Gln Thr Leu Arg Thr Thr Val Lys Glu Thr 
            580                 585                 590         


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
        595                 600                 605             


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
    610                 615                 620                 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
625                 630                 635     


<210>  9
<211>  841
<212>  PRT
<213>  Model 9 - Anti-CD123 - IgG4 (CH2CH3) - IL1R2 (extracellular) - CD8 (Hinge)

<400>  9

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Lys Trp Ala Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp 
    130                 135                 140                 


Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Glu Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Pro Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Pro Glu Phe Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly Lys Phe Thr Leu Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser 
465                 470                 475                 480 


Cys Arg Phe Arg Gly Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly 
                485                 490                 495     


Glu Pro Val Ala Leu Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala 
            500                 505                 510         


Ser Val Ser Pro Arg Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala 
        515                 520                 525             


Arg Thr Val Pro Gly Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly 
    530                 535                 540                 


Ala Leu Trp Leu Leu Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val 
545                 550                 555                 560 


Cys Thr Thr Arg Asn Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu 
                565                 570                 575     


Arg Val Phe Glu Asn Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro 
            580                 585                 590         


Gln Ile Leu Thr Leu Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu 
        595                 600                 605             


Ser Glu Phe Thr Arg Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys 
    610                 615                 620                 


Asp Ser Leu Leu Leu Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg 
625                 630                 635                 640 


Gly Thr Thr His Leu Leu Val His Asp Val Ala Leu Glu Asp Ala Gly 
                645                 650                 655     


Tyr Tyr Arg Cys Val Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn 
            660                 665                 670         


Ile Thr Arg Ser Ile Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr 
        675                 680                 685             


Ile Pro Val Ile Ile Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly 
    690                 695                 700                 


Ser Arg Leu Thr Ile Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro 
705                 710                 715                 720 


Leu Thr Thr Met Leu Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser 
                725                 730                 735     


Ala Tyr Pro Gly Gly Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser 
            740                 745                 750         


Glu Asn Asn Glu Asn Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val 
        755                 760                 765             


Thr Arg Glu Asp Leu His Met Asp Phe Lys Cys Val Val His Asn Thr 
    770                 775                 780                 


Leu Ser Phe Gln Thr Leu Arg Thr Thr Val Lys Glu Thr Thr Thr Pro 
785                 790                 795                 800 


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
                805                 810                 815     


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
            820                 825                 830         


Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        835                 840     


<210>  10
<211>  808
<212>  PRT
<213>  Model 10 - Anti-CD123 - IgG4 (Hinge-CH2CH3) - IL1R2 (extracellular)

<400>  10

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Lys Trp Ala Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp 
    130                 135                 140                 


Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Glu Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Pro Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Leu Glu Ile Lys Arg Glu Ser Lys Tyr Gly Pro Pro 
                245                 250                 255     


Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    290                 295                 300                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Phe Thr 
465                 470                 475                 480 


Leu Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg 
                485                 490                 495     


Gly Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala 
            500                 505                 510         


Leu Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro 
        515                 520                 525             


Arg Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro 
    530                 535                 540                 


Gly Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu 
545                 550                 555                 560 


Leu Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg 
                565                 570                 575     


Asn Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu 
            580                 585                 590         


Asn Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr 
        595                 600                 605             


Leu Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr 
    610                 615                 620                 


Arg Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu 
625                 630                 635                 640 


Leu Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His 
                645                 650                 655     


Leu Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys 
            660                 665                 670         


Val Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser 
        675                 680                 685             


Ile Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile 
    690                 695                 700                 


Ile Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr 
705                 710                 715                 720 


Ile Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met 
                725                 730                 735     


Leu Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly 
            740                 745                 750         


Gly Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu 
        755                 760                 765             


Asn Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp 
    770                 775                 780                 


Leu His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln 
785                 790                 795                 800 


Thr Leu Arg Thr Thr Val Lys Glu 
                805             


<210>  11
<211>  591
<212>  PRT
<213>  Model 11 - Anti-CD123 - IgG4 (Hinge) - IL1R2 (extracellular)

<400>  11

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Lys Trp Ala Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp 
    130                 135                 140                 


Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Glu Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Pro Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Leu Glu Ile Lys Arg Glu Ser Lys Tyr Gly Pro Pro 
                245                 250                 255     


Cys Pro Ser Cys Pro Phe Thr Leu Gln Pro Ala Ala His Thr Gly Ala 
            260                 265                 270         


Ala Arg Ser Cys Arg Phe Arg Gly Arg His Tyr Lys Arg Glu Phe Arg 
        275                 280                 285             


Leu Glu Gly Glu Pro Val Ala Leu Arg Cys Pro Gln Val Pro Tyr Trp 
    290                 295                 300                 


Leu Trp Ala Ser Val Ser Pro Arg Ile Asn Leu Thr Trp His Lys Asn 
305                 310                 315                 320 


Asp Ser Ala Arg Thr Val Pro Gly Glu Glu Glu Thr Arg Met Trp Ala 
                325                 330                 335     


Gln Asp Gly Ala Leu Trp Leu Leu Pro Ala Leu Gln Glu Asp Ser Gly 
            340                 345                 350         


Thr Tyr Val Cys Thr Thr Arg Asn Ala Ser Tyr Cys Asp Lys Met Ser 
        355                 360                 365             


Ile Glu Leu Arg Val Phe Glu Asn Thr Asp Ala Phe Leu Pro Phe Ile 
    370                 375                 380                 


Ser Tyr Pro Gln Ile Leu Thr Leu Ser Thr Ser Gly Val Leu Val Cys 
385                 390                 395                 400 


Pro Asp Leu Ser Glu Phe Thr Arg Asp Lys Thr Asp Val Lys Ile Gln 
                405                 410                 415     


Trp Tyr Lys Asp Ser Leu Leu Leu Asp Lys Asp Asn Glu Lys Phe Leu 
            420                 425                 430         


Ser Val Arg Gly Thr Thr His Leu Leu Val His Asp Val Ala Leu Glu 
        435                 440                 445             


Asp Ala Gly Tyr Tyr Arg Cys Val Leu Thr Phe Ala His Glu Gly Gln 
    450                 455                 460                 


Gln Tyr Asn Ile Thr Arg Ser Ile Glu Leu Arg Ile Lys Lys Lys Lys 
465                 470                 475                 480 


Glu Glu Thr Ile Pro Val Ile Ile Ser Pro Leu Lys Thr Ile Ser Ala 
                485                 490                 495     


Ser Leu Gly Ser Arg Leu Thr Ile Pro Cys Lys Val Phe Leu Gly Thr 
            500                 505                 510         


Gly Thr Pro Leu Thr Thr Met Leu Trp Trp Thr Ala Asn Asp Thr His 
        515                 520                 525             


Ile Glu Ser Ala Tyr Pro Gly Gly Arg Val Thr Glu Gly Pro Arg Gln 
    530                 535                 540                 


Glu Tyr Ser Glu Asn Asn Glu Asn Tyr Ile Glu Val Pro Leu Ile Phe 
545                 550                 555                 560 


Asp Pro Val Thr Arg Glu Asp Leu His Met Asp Phe Lys Cys Val Val 
                565                 570                 575     


His Asn Thr Leu Ser Phe Gln Thr Leu Arg Thr Thr Val Lys Glu 
            580                 585                 590     


<210>  12
<211>  796
<212>  PRT
<213>  Model 12 - Anti-CD123 - IgG4 (CH2CH3) - IL1R2 (extracellular)

<400>  12

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Lys Trp Ala Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp 
    130                 135                 140                 


Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Glu Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Pro Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala Pro Glu Phe Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    450                 455                 460                 


Gly Lys Phe Thr Leu Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser 
465                 470                 475                 480 


Cys Arg Phe Arg Gly Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly 
                485                 490                 495     


Glu Pro Val Ala Leu Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala 
            500                 505                 510         


Ser Val Ser Pro Arg Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala 
        515                 520                 525             


Arg Thr Val Pro Gly Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly 
    530                 535                 540                 


Ala Leu Trp Leu Leu Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val 
545                 550                 555                 560 


Cys Thr Thr Arg Asn Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu 
                565                 570                 575     


Arg Val Phe Glu Asn Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro 
            580                 585                 590         


Gln Ile Leu Thr Leu Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu 
        595                 600                 605             


Ser Glu Phe Thr Arg Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys 
    610                 615                 620                 


Asp Ser Leu Leu Leu Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg 
625                 630                 635                 640 


Gly Thr Thr His Leu Leu Val His Asp Val Ala Leu Glu Asp Ala Gly 
                645                 650                 655     


Tyr Tyr Arg Cys Val Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn 
            660                 665                 670         


Ile Thr Arg Ser Ile Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr 
        675                 680                 685             


Ile Pro Val Ile Ile Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly 
    690                 695                 700                 


Ser Arg Leu Thr Ile Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro 
705                 710                 715                 720 


Leu Thr Thr Met Leu Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser 
                725                 730                 735     


Ala Tyr Pro Gly Gly Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser 
            740                 745                 750         


Glu Asn Asn Glu Asn Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val 
        755                 760                 765             


Thr Arg Glu Asp Leu His Met Asp Phe Lys Cys Val Val His Asn Thr 
    770                 775                 780                 


Leu Ser Phe Gln Thr Leu Arg Thr Thr Val Lys Glu 
785                 790                 795     


<210>  13
<211>  327
<212>  PRT
<213>  IgG4 Heavy Chain - UniProtKB: P01861

<400>  13

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  14
<211>  98
<212>  PRT
<213>  CH1 domain - 1-98

<400>  14

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  15
<211>  12
<212>  PRT
<213>  Hinge - 99 -110

<400>  15

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  16
<211>  110
<212>  PRT
<213>  CH2 domain - 111 - 220

<400>  16

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  17
<211>  107
<212>  PRT
<213>  CH3 domain - 221-327

<400>  17

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  18
<211>  398
<212>  PRT
<213>  IL1R2 - UniProtKB: P27930

<400>  18

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn 
    290                 295                 300                 


Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu 
305                 310                 315                 320 


His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr 
                325                 330                 335     


Leu Arg Thr Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile 
            340                 345                 350         


Val Leu Ala Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp 
        355                 360                 365             


Met His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr 
    370                 375                 380                 


Val Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
385                 390                 395             


<210>  19
<211>  13
<212>  PRT
<213>  Signal Peptide - 1 -13

<400>  19

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala 
1               5                   10              


<210>  20
<211>  330
<212>  PRT
<213>  Extracellular Domain - 14 - 343

<400>  20

Phe Thr Leu Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg 
1               5                   10                  15      


Phe Arg Gly Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro 
            20                  25                  30          


Val Ala Leu Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val 
        35                  40                  45              


Ser Pro Arg Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr 
    50                  55                  60                  


Val Pro Gly Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu 
65                  70                  75                  80  


Trp Leu Leu Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr 
                85                  90                  95      


Thr Arg Asn Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val 
            100                 105                 110         


Phe Glu Asn Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile 
        115                 120                 125             


Leu Thr Leu Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu 
    130                 135                 140                 


Phe Thr Arg Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser 
145                 150                 155                 160 


Leu Leu Leu Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr 
                165                 170                 175     


Thr His Leu Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr 
            180                 185                 190         


Arg Cys Val Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr 
        195                 200                 205             


Arg Ser Ile Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro 
    210                 215                 220                 


Val Ile Ile Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg 
225                 230                 235                 240 


Leu Thr Ile Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr 
                245                 250                 255     


Thr Met Leu Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr 
            260                 265                 270         


Pro Gly Gly Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn 
        275                 280                 285             


Asn Glu Asn Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg 
    290                 295                 300                 


Glu Asp Leu His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser 
305                 310                 315                 320 


Phe Gln Thr Leu Arg Thr Thr Val Lys Glu 
                325                 330 


<210>  21
<211>  26
<212>  PRT
<213>  Transmembrane Domain - 344-369

<400>  21

Ala Ser Ser Thr Phe Ser Trp Gly Ile Val Leu Ala Pro Leu Ser Leu 
1               5                   10                  15      


Ala Phe Leu Val Leu Gly Gly Ile Trp Met 
            20                  25      


<210>  22
<211>  29
<212>  PRT
<213>  Cytoplasmatic Domain - 370 - 398

<400>  22

His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr Val 
1               5                   10                  15      


Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
            20                  25                  


<210>  23
<211>  529
<212>  PRT
<213>  Anti CD33 CAR 3rd Generation

<400>  23

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu 
145                 150                 155                 160 


Asp Asn Tyr Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Thr Lys Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Val Lys Arg Thr Val Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
                245                 250                 255     


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
            260                 265                 270         


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        275                 280                 285             


Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
    290                 295                 300                 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
305                 310                 315                 320 


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
                325                 330                 335     


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
            340                 345                 350         


Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        355                 360                 365             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    370                 375                 380                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
385                 390                 395                 400 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
                405                 410                 415     


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            420                 425                 430         


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        435                 440                 445             


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    450                 455                 460                 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
465                 470                 475                 480 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                485                 490                 495     


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510         


Pro Gly Ser Arg Pro Arg Leu Glu Gln Ser Thr Ser Gly Leu Gln Asn 
        515                 520                 525             


Leu 
    


<210>  24
<211>  245
<212>  PRT
<213>  Anti-CD33 (VH-liker-VL) 1 - 245

<400>  24

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Asp Ser 
            20                  25                  30          


Asn Ile His Trp Val Arg Gln Ala Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asn Arg Ala Thr Leu Thr Val Asp Asn Pro Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Tyr Cys 
                85                  90                  95      


Val Asn Gly Asn Pro Trp Leu Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Leu 
145                 150                 155                 160 


Asp Asn Tyr Gly Ile Arg Phe Leu Thr Trp Phe Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Met Tyr Ala Ala Ser Asn Gln Gly Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Thr Lys Glu Val Pro Trp Ser Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Val Lys Arg Thr Val 
                245 


<210>  25
<211>  45
<212>  PRT
<213>  CD8 Hinge 246 - 290

<400>  25

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  26
<211>  239
<212>  PRT
<213>  Intracelular Domains 291 - 580

<400>  26

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
65                  70                  75                  80  


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                85                  90                  95      


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            100                 105                 110         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        115                 120                 125             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    130                 135                 140                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
145                 150                 155                 160 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                165                 170                 175     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            180                 185                 190         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        195                 200                 205             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Pro Gly 
    210                 215                 220                 


Ser Arg Pro Arg Leu Glu Gln Ser Thr Ser Gly Leu Gln Asn Leu 
225                 230                 235                 


<210>  27
<211>  516
<212>  PRT
<213>  Anti CD123 CAR 3rd Generation

<400>  27

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Lys Trp Ala Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp 
    130                 135                 140                 


Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Glu Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Pro Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg 
                245                 250                 255     


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
            260                 265                 270         


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
        275                 280                 285             


Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val 
    290                 295                 300                 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
305                 310                 315                 320 


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
                325                 330                 335     


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
            340                 345                 350         


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys 
        355                 360                 365             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    370                 375                 380                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
385                 390                 395                 400 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                405                 410                 415     


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            420                 425                 430         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        435                 440                 445             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    450                 455                 460                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
465                 470                 475                 480 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                485                 490                 495     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            500                 505                 510         


Leu Pro Pro Arg 
        515     


<210>  28
<211>  249
<212>  PRT
<213>  Anti-CD123 (VH-liker-VL) - 1 - 249

<400>  28

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Lys Trp Ala Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp 
    130                 135                 140                 


Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Glu Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp 
                165                 170                 175     


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Pro Leu Ile Tyr Trp Ala 
            180                 185                 190         


Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly 
225                 230                 235                 240 


Gln Gly Thr Lys Leu Glu Ile Lys Arg 
                245                 


<210>  29
<211>  45
<212>  PRT
<213>  CD8 Hinge - 250 - 294

<400>  29

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  30
<211>  222
<212>  PRT
<213>  Intracelular Domains 295 - 517

<400>  30

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
65                  70                  75                  80  


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                85                  90                  95      


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            100                 105                 110         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        115                 120                 125             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    130                 135                 140                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
145                 150                 155                 160 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                165                 170                 175     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            180                 185                 190         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        195                 200                 205             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220         


