                         SEQUENCE LISTING

<110>  Merus N.V.
 
<120>  TRUNCATED MULTIVALENT MULTIMERS

<130>  P122912PC00

<150>  US 62/786,806
<151>  2018-12-31

<160>  93    

<170>  PatentIn version 3.5

<210>  1
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Translation of common light chain (cLC)

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  2
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Ser Lys Tyr Gly Pro Pro 
1               5           


<210>  3
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  4

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  5
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  5

Glu Arg Lys Ser Ser Val Glu Ser Pro Pro Ser Pro 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  6

Glu Arg Lys Cys Ser Val Glu Ser Pro Pro Ser Pro 
1               5                   10          


<210>  7
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  8
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  8

Glu Ser Lys Tyr Gly Pro Pro Ser Pro Ser Ser Pro 
1               5                   10          


<210>  9
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  9

Glu Arg Lys Ser Ser Val Glu Ala Pro Pro Val Ala Gly 
1               5                   10              


<210>  10
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  10

Glu Arg Lys Cys Ser Val Glu Ala Pro Pro Val Ala Gly 
1               5                   10              


<210>  11
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  11

Glu Ser Lys Tyr Gly Pro Pro Ala Pro Glu Phe Leu Gly Gly 
1               5                   10                  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  12

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  13
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  13

Glu Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  14
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Pro Val Ala Gly 
1               5                   10                  15      


<210>  15
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  15

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  16

Glu Arg Lys Ser Ser Val Glu Ser Pro Pro Ser Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  17
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  17

Glu Arg Lys Cys Ser Val Glu Ser Pro Pro Ser Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  18
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  18

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210>  19
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  19

Glu Ser Lys Tyr Gly Pro Pro Ser Pro Ser Ser Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210>  20
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  20

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  21
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  21

Glu Arg Lys Ser Ser Val Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala 
1               5                   10                  15      


Lys Ala Pro Pro Val Ala Gly 
            20              


<210>  22
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  22

Glu Arg Lys Cys Ser Val Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala 
1               5                   10                  15      


Lys Ala Pro Pro Val Ala Gly 
            20              


<210>  23
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  23

Glu Ser Lys Tyr Gly Pro Pro Glu Ala Ala Ala Lys Glu Ala Ala Ala 
1               5                   10                  15      


Lys Ala Pro Glu Phe Leu Gly Gly 
            20                  


<210>  24
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  24

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys Ala Pro Glu Leu Leu Gly Gly 
            20                  25          


<210>  25
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  25

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Glu Ala Ala Ala 
1               5                   10                  15      


Lys Glu Ala Ala Ala Lys Ala Pro Glu Phe Leu Gly Gly 
            20                  25                  


<210>  26
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  27
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  27

Cys Pro Pro Cys Pro 
1               5   


<210>  28
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  28

Ala Pro Glu Leu Leu Gly Gly 
1               5           


<210>  29
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  30
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  30

Glu Arg Lys Cys Cys Val Glu 
1               5           


<210>  31
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  31

Ala Pro Pro Val Ala Gly 
1               5       


<210>  32
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  32

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro 
    50                  55                  60                  


Glu Phe Leu Gly Gly 
65                  


<210>  33
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  33

Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
1               5                   10                  15      


Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
            20                  25                  30          


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        35                  40                  45              


Cys Pro 
    50  


<210>  34
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Pro Glu Phe Leu Gly Gly 
1               5           


<210>  35
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  35

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210>  36
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  36

Cys Pro Ser Cys Pro 
1               5   


<210>  37
<211>  52
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  37

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val 
        35                  40                  45              


Val Gln Pro Gly 
    50          


<210>  38
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NVNHKPSNTKVDKRVEPKSCDKTHTSPPSPEVQLVESGGGVVQPG

<400>  38

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro Glu Val 
            20                  25                  30          


Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40                  45  


<210>  39
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  39

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Pro Lys Ser Cys Asp Lys Thr His Thr Glu Val Gln Leu Val Glu Ser 
            20                  25                  30          


Gly Gly Gly Val Val Gln Pro Gly 
        35                  40  


<210>  40
<211>  46
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  40

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Pro Lys Ser Cys Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
            20                  25                  30          


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40                  45      


<210>  41
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  41

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Pro Lys Ser Cys Asp Lys Thr His Thr Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Ala Pro Glu Leu Leu Gly Gly Glu Val Gln Leu Val Glu 
        35                  40                  45              


Ser Gly Gly Gly Val Val Gln Pro Gly 
    50                  55          


<210>  42
<211>  47
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  42

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Pro Lys Ser Cys Asp Lys Thr His Thr Ala Pro Glu Leu Leu Gly Gly 
            20                  25                  30          


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40                  45          


<210>  43
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  43

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Ser Ser Val Glu Ser Pro Pro Ser Pro Ala Pro Pro Val Ala 
            20                  25                  30          


Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40                  45              


<210>  44
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  44

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Ser Ser Val Glu Ser Pro Pro Ser Pro Glu Val Gln Leu Val 
            20                  25                  30          


Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40          


<210>  45
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  45

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Ser Ser Val Glu Ala Pro Pro Val Ala Gly Glu Val Gln Leu 
            20                  25                  30          


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40              


<210>  46
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  46

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Cys Ser Val Glu Ser Pro Pro Ser Pro Ala Pro Pro Val Ala 
            20                  25                  30          


Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40                  45              


<210>  47
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  47

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Cys Ser Val Glu Ser Pro Pro Ser Pro Glu Val Gln Leu Val 
            20                  25                  30          


Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40          


<210>  48
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  48

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Cys Ser Val Glu Ala Pro Pro Val Ala Gly Glu Val Gln Leu 
            20                  25                  30          


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40              


<210>  49
<211>  46
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  49

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Pro Val Ala Gly Glu 
            20                  25                  30          


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40                  45      


<210>  50
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  50

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            20                  25                  30          


Gly Gly Gly Val Val Gln Pro Gly 
        35                  40  


<210>  51
<211>  53
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  51

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Ser Ser Val Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            20                  25                  30          


Ala Pro Pro Val Ala Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        35                  40                  45              


Val Val Gln Pro Gly 
    50              


<210>  52
<211>  53
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  52

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
1               5                   10                  15      


Arg Lys Cys Ser Val Glu Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            20                  25                  30          


Ala Pro Pro Val Ala Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        35                  40                  45              


Val Val Gln Pro Gly 
    50              


<210>  53
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  53

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Ala Pro Glu Phe Leu 
            20                  25                  30          


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
        35                  40                  45              


Gly 
    


<210>  54
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  54

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Glu Val Gln Leu Val 
            20                  25                  30          


Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40          


<210>  55
<211>  59
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  55

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Glu Ala Ala Ala Lys 
            20                  25                  30          


Glu Ala Ala Ala Lys Ala Pro Glu Phe Leu Gly Gly Glu Val Gln Leu 
        35                  40                  45              


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
    50                  55                  


<210>  56
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  56

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Ser Lys Tyr Gly Pro Pro Ser Pro Ser Ser Pro Ala Pro Glu Phe Leu 
            20                  25                  30          


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro 
        35                  40                  45              


Gly 
    


<210>  57
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  57

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Ser Lys Tyr Gly Pro Pro Ser Pro Ser Ser Pro Glu Val Gln Leu Val 
            20                  25                  30          


Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40          


<210>  58
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  58

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Ser Lys Tyr Gly Pro Pro Ala Pro Glu Phe Leu Gly Gly Glu Val Gln 
            20                  25                  30          


Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
        35                  40                  


<210>  59
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  59

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Ser Lys Tyr Gly Pro Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly 
        35          


<210>  60
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  60

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Ser Lys Tyr Gly Pro Pro Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            20                  25                  30          


Ala Pro Glu Phe Leu Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly 
        35                  40                  45              


Gly Val Val Gln Pro Gly 
    50                  


<210>  61
<211>  52
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  61

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
1               5                   10                  15      


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met 
    50          


<210>  62
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  common light chain variable domain (IGKV1-39/jk1)


<220>
<221>  CDS
<222>  (1)..(321)

<400>  62
gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gca agt cag agc att agc agc tac         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr           
            20                  25                  30                    

tta aat tgg tat cag cag aaa cca ggg aaa gcc cct aag ctc ctg atc        144
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat gct gca tcc agt ttg caa agt ggg gtc cca tca agg ttc agt ggc        192
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gat ttc act ctc acc atc agc agt ctg caa cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gca act tac tac tgt caa cag agt tac agt acc cct cca        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro           
                85                  90                  95                

acg ttc ggc caa ggg acc aag gtg gag atc aaa                            321
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  63
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  64
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  64

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  65
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  V-region IGKV1-39A

<400>  65

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
                85                  90                  95  


<210>  66
<211>  382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF6058 in Mase DNA

<400>  66
ggcccagccg gccatggccc aggtgcagct ggtgcagtct ggggctgacg tgaagaagcc       60

tggggcctca gtgaaggtca cgtgcaaggc ttctggatac accttcaccg gctactatat      120

gcactgggtg cgacaggccc ctggacaagc tcttgagtgg atgggatgga tcaaccctca      180

aagtggtggc acaaactatg caaagaagtt tcagggcagg gtctctatga ccagggagac      240

gtccacaagc acagcctaca tgcagctgag caggctgaga tctgacgaca cggctacgta      300

ttactgtgca agagatcatg gttctcgtca tttctggtct tactggggct ttgattattg      360

gggccaaggt accctggtca cc                                               382


<210>  67
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF6058 in Mase AA

<400>  67

Gln Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Thr Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Ala Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Gln Ser Gly Gly Thr Asn Tyr Ala Lys Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Ser Met Thr Arg Glu Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Gly Ser Arg His Phe Trp Ser Tyr Trp Gly Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120     


<210>  68
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF3004 DNA

<400>  68
caggtgcagc tgaagcagtc tggggctgag ctggtgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta cactttcact ggctactata taaactgggt gaagcagagg      120

cctggacagg gacttgagtg gattgcaagg atttatcctg gaagtggtta tacttactac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaag aatcctccag cactgcctac      240

atgcacctca gcagcctgac atctgaggac tctgctgtct atttctgtgc aagaccccac      300

tatggttacg acgactggta cttcggtgtc tggggcacag gcaccacggt cacc            354


<210>  69
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF3004 AA

<400>  69

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Arg Ile Tyr Pro Gly Ser Gly Tyr Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Glu Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Pro His Tyr Gly Tyr Asp Asp Trp Tyr Phe Gly Val Trp Gly 
            100                 105                 110         


Thr Gly Thr Thr Val Thr 
        115             


<210>  70
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF1337 DNA

<400>  70
gaggtgcagc tggtggagac tggggctgag gtgaagaagc cgggggcctc agtgaaggtc       60

tcctgcaagg cttctgacta catcttcacc aaatatgaca tcaactgggt gcgccaggcc      120

cctggacaag ggcttgaatg gatgggatgg atgagcgcta acactggaaa cacgggctat      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccataaa cacagcctac      240

atggagctga gcagcctgac atctggtgac acggccgttt atttctgtgc gaggagtagt      300

cttttcaaga cagagacggc gccctactat cacttcgctc tggacgtctg gggccaaggg      360

accacggtca cc                                                          372


<210>  71
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1337 AA

<400>  71

Glu Val Gln Leu Val Glu Thr Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Asp Tyr Ile Phe Thr Lys Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Ser Ala Asn Thr Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Gly Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ser Leu Phe Lys Thr Glu Thr Ala Pro Tyr Tyr His Phe 
            100                 105                 110         


Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        115                 120                 


<210>  72
<211>  1099
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding MF1337-CH1-IgG1 G4S linker-MF1122

<400>  72
ggcccagccg gccatggccg aggtgcagct ggtggagact ggggctgagg tgaagaagcc       60

gggggcctca gtgaaggtct cctgcaaggc ttctgactac atcttcacca aatatgacat      120

caactgggtg cgccaggccc ctggacaagg gcttgaatgg atgggatgga tgagcgctaa      180

cactggaaac acgggctatg cacagaagtt ccagggcaga gtcaccatga ccagggacac      240

gtccataaac acagcctaca tggagctgag cagcctgaca tctggtgaca cggccgttta      300

tttctgtgcg aggagtagtc ttttcaagac agagacggcg ccctactatc acttcgctct      360

ggacgtctgg ggccaaggga ccacggtcac cgtctccagt gctagcacca agggcccatc      420

ggtcttcccc ctggcaccct cctccaagtc cacgtctggg ggcacagcgg ccctgggctg      480

cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac      540

cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag      600

cgtcgtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca      660

caagcccagc aacaccaagg tggacaagag agttgagccc aagagctgcg acggcggtgg      720

cggcagcggc ggcggaggca gcgaggtgca gctggtggag tctgggggag gcgtggtcca      780

gcctgggagg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctatgg      840

catgcactgg gtccgccagg ctccaggcaa ggggctggag tgggtggcag ttatatcata      900

tgatggaagt aataaatact atgcagactc cgtgaagggc cgattcacca tctccagaga      960

caattccaag aacacgctgt atctgcaaat gaacagcctg agagctgagg acacggccgt     1020

gtattactgt gcaagagccc tcttcacgac catcgccatg gactattggg gccaaggtac     1080

ccttgtcacc gtctcgagt                                                  1099


<210>  73
<211>  366
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1337-CH1-IgG1 G4S linker -MF1122

<400>  73

Ala Gln Pro Ala Met Ala Glu Val Gln Leu Val Glu Thr Gly Ala Glu 
1               5                   10                  15      


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Asp 
            20                  25                  30          


Tyr Ile Phe Thr Lys Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly 
        35                  40                  45              


Gln Gly Leu Glu Trp Met Gly Trp Met Ser Ala Asn Thr Gly Asn Thr 
    50                  55                  60                  


Gly Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
65                  70                  75                  80  


Ser Ile Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Gly Asp 
                85                  90                  95      


Thr Ala Val Tyr Phe Cys Ala Arg Ser Ser Leu Phe Lys Thr Glu Thr 
            100                 105                 110         


Ala Pro Tyr Tyr His Phe Ala Leu Asp Val Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
                245                 250                 255     


Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            260                 265                 270         


Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn 
    290                 295                 300                 


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
305                 310                 315                 320 


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
                325                 330                 335     


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Leu Phe Thr Thr Ile Ala 
            340                 345                 350         


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365     


<210>  74
<211>  1117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding MF 1377-CH1-IgG1 H linker- MF1122

<400>  74
ggcccagccg gccatggccg aggtgcagct ggtggagact ggggctgagg tgaagaagcc       60

gggggcctca gtgaaggtct cctgcaaggc ttctgactac atcttcacca aatatgacat      120

caactgggtg cgccaggccc ctggacaagg gcttgaatgg atgggatgga tgagcgctaa      180

cactggaaac acgggctatg cacagaagtt ccagggcaga gtcaccatga ccagggacac      240

gtccataaac acagcctaca tggagctgag cagcctgaca tctggtgaca cggccgttta      300

tttctgtgcg aggagtagtc ttttcaagac agagacggcg ccctactatc acttcgctct      360

ggacgtctgg ggccaaggga ccacggtcac cgtctccagt gctagcacca agggcccatc      420

ggtcttcccc ctggcaccct cctccaagtc cacgtctggg ggcacagcgg ccctgggctg      480

cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac      540

cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag      600

cgtcgtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca      660

caagcccagc aacaccaagg tggacaagag agttgagccc aagagctgcg acaagaccca      720

caccagcccc cccagccccg ctcccgagct gctgggcggc gaggtgcagc tggtggagtc      780

tgggggaggc gtggtccagc ctgggaggtc cctgagactc tcctgtgcag cctctggatt      840

caccttcagt agctatggca tgcactgggt ccgccaggct ccaggcaagg ggctggagtg      900

ggtggcagtt atatcatatg atggaagtaa taaatactat gcagactccg tgaagggccg      960

attcaccatc tccagagaca attccaagaa cacgctgtat ctgcaaatga acagcctgag     1020

agctgaggac acggccgtgt attactgtgc aagagccctc ttcacgacca tcgccatgga     1080

ctattggggc caaggtaccc ttgtcaccgt ctcgagt                              1117


<210>  75
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF 1377-CH1-IgG1 H linker-MF1122

<400>  75

Ala Gln Pro Ala Met Ala Glu Val Gln Leu Val Glu Thr Gly Ala Glu 
1               5                   10                  15      


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Asp 
            20                  25                  30          


Tyr Ile Phe Thr Lys Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly 
        35                  40                  45              


Gln Gly Leu Glu Trp Met Gly Trp Met Ser Ala Asn Thr Gly Asn Thr 
    50                  55                  60                  


Gly Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
65                  70                  75                  80  


Ser Ile Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Gly Asp 
                85                  90                  95      


Thr Ala Val Tyr Phe Cys Ala Arg Ser Ser Leu Phe Lys Thr Glu Thr 
            100                 105                 110         


Ala Pro Tyr Tyr His Phe Ala Leu Asp Val Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Glu Val Gln 
                245                 250                 255     


Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg 
            260                 265                 270         


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met His 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile 
    290                 295                 300                 


Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
305                 310                 315                 320 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
                325                 330                 335     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala 
            340                 345                 350         


Leu Phe Thr Thr Ile Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser 
    370         


<210>  76
<211>  1087
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding MF1377-CH1-IgG2A MH linker -MF1122

<400>  76
ggcccagccg gccatggccg aggtgcagct ggtggagact ggggctgagg tgaagaagcc       60

gggggcctca gtgaaggtct cctgcaaggc ttctgactac atcttcacca aatatgacat      120

caactgggtg cgccaggccc ctggacaagg gcttgaatgg atgggatgga tgagcgctaa      180

cactggaaac acgggctatg cacagaagtt ccagggcaga gtcaccatga ccagggacac      240

gtccataaac acagcctaca tggagctgag cagcctgaca tctggtgaca cggccgttta      300

tttctgtgcg aggagtagtc ttttcaagac agagacggcg ccctactatc acttcgctct      360

ggacgtctgg ggccaaggga ccacggtcac cgtctccagt gctagcacca agggccccag      420

cgtgttcccc ctggccccct gcagccggag caccagcgag agcaccgccg ccctgggctg      480

cctggtgaag gactacttcc ccgagcccgt gaccgtgagc tggaacagcg gcgccctgac      540

cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc ggcctgtaca gcctgagcag      600

cgtggtgacg gtgcccagca gcaacttcgg cacccagacc tacacctgca acgtggacca      660

caagcccagc aacaccaagg tggacaagac cgtggagcgg aagagcagcg tggagagccc      720

ccccagcccc gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc      780

cctgagactc tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt      840

ccgccaggct ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa      900

taaatactat gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa      960

cacgctgtat ctgcaaatga acagcctgag agctgaggac acggccgtgt attactgtgc     1020

aagagccctc ttcacgacca tcgccatgga ctattggggc caaggtaccc ttgtcaccgt     1080

ctcgagt                                                               1087


<210>  77
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1377-CH1-IgG2A MH linker -MF1122

<400>  77

Ala Gln Pro Ala Met Ala Glu Val Gln Leu Val Glu Thr Gly Ala Glu 
1               5                   10                  15      


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Asp 
            20                  25                  30          


Tyr Ile Phe Thr Lys Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly 
        35                  40                  45              


Gln Gly Leu Glu Trp Met Gly Trp Met Ser Ala Asn Thr Gly Asn Thr 
    50                  55                  60                  


Gly Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
65                  70                  75                  80  


Ser Ile Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Gly Asp 
                85                  90                  95      


Thr Ala Val Tyr Phe Cys Ala Arg Ser Ser Leu Phe Lys Thr Glu Thr 
            100                 105                 110         


Ala Pro Tyr Tyr His Phe Ala Leu Asp Val Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
        195                 200                 205             


Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Thr Val Glu Arg Lys Ser Ser Val Glu Ser Pro 
225                 230                 235                 240 


Pro Ser Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
                245                 250                 255     


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            260                 265                 270         


Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        275                 280                 285             


Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
    290                 295                 300                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
305                 310                 315                 320 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                325                 330                 335     


Tyr Tyr Cys Ala Arg Ala Leu Phe Thr Thr Ile Ala Met Asp Tyr Trp 
            340                 345                 350         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360         


<210>  78
<211>  1096
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding MF1377-CH1-IgG1 MH linker- MF1122

<400>  78
ggcccagccg gccatggccg aggtgcagct ggtggagact ggggctgagg tgaagaagcc       60

gggggcctca gtgaaggtct cctgcaaggc ttctgactac atcttcacca aatatgacat      120

caactgggtg cgccaggccc ctggacaagg gcttgaatgg atgggatgga tgagcgctaa      180

cactggaaac acgggctatg cacagaagtt ccagggcaga gtcaccatga ccagggacac      240

gtccataaac acagcctaca tggagctgag cagcctgaca tctggtgaca cggccgttta      300

tttctgtgcg aggagtagtc ttttcaagac agagacggcg ccctactatc acttcgctct      360

ggacgtctgg ggccaaggga ccacggtcac cgtctccagt gctagcacca agggcccatc      420

ggtcttcccc ctggcaccct cctccaagtc cacgtctggg ggcacagcgg ccctgggctg      480

cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac      540

cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag      600

cgtcgtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca      660

caagcccagc aacaccaagg tggacaagag agttgagccc aagagctgcg acaagaccca      720

caccagcccc cccagccccg aggtgcagct ggtggagtct gggggaggcg tggtccagcc      780

tgggaggtcc ctgagactct cctgtgcagc ctctggattc accttcagta gctatggcat      840

gcactgggtc cgccaggctc caggcaaggg gctggagtgg gtggcagtta tatcatatga      900

tggaagtaat aaatactatg cagactccgt gaagggccga ttcaccatct ccagagacaa      960

ttccaagaac acgctgtatc tgcaaatgaa cagcctgaga gctgaggaca cggccgtgta     1020

ttactgtgca agagccctct tcacgaccat cgccatggac tattggggcc aaggtaccct     1080

tgtcaccgtc tcgagt                                                     1096


<210>  79
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1377-CH1-IgG1 MH linker-MF1122

<400>  79

Ala Gln Pro Ala Met Ala Glu Val Gln Leu Val Glu Thr Gly Ala Glu 
1               5                   10                  15      


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Asp 
            20                  25                  30          


Tyr Ile Phe Thr Lys Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly 
        35                  40                  45              


Gln Gly Leu Glu Trp Met Gly Trp Met Ser Ala Asn Thr Gly Asn Thr 
    50                  55                  60                  


Gly Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
65                  70                  75                  80  


Ser Ile Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Gly Asp 
                85                  90                  95      


Thr Ala Val Tyr Phe Cys Ala Arg Ser Ser Leu Phe Lys Thr Glu Thr 
            100                 105                 110         


Ala Pro Tyr Tyr His Phe Ala Leu Asp Val Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Ser Pro Pro Ser Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                245                 250                 255     


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
        275                 280                 285             


Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys 
    290                 295                 300                 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
305                 310                 315                 320 


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
                325                 330                 335     


Thr Ala Val Tyr Tyr Cys Ala Arg Ala Leu Phe Thr Thr Ile Ala Met 
            340                 345                 350         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365 


<210>  80
<211>  1081
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding MF1377-CH1-IgG1 UH linker-MF1122

<400>  80
ggcccagccg gccatggccg aggtgcagct ggtggagact ggggctgagg tgaagaagcc       60

gggggcctca gtgaaggtct cctgcaaggc ttctgactac atcttcacca aatatgacat      120

caactgggtg cgccaggccc ctggacaagg gcttgaatgg atgggatgga tgagcgctaa      180

cactggaaac acgggctatg cacagaagtt ccagggcaga gtcaccatga ccagggacac      240

gtccataaac acagcctaca tggagctgag cagcctgaca tctggtgaca cggccgttta      300

tttctgtgcg aggagtagtc ttttcaagac agagacggcg ccctactatc acttcgctct      360

ggacgtctgg ggccaaggga ccacggtcac cgtctccagt gctagcacca agggcccatc      420

ggtcttcccc ctggcaccct cctccaagtc cacgtctggg ggcacagcgg ccctgggctg      480

cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac      540

cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag      600

cgtcgtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca      660

caagcccagc aacaccaagg tggacaagag agttgagccc aagagctgcg acaagaccca      720

caccgaggtg cagctggtgg agtctggggg aggcgtggtc cagcctggga ggtccctgag      780

actctcctgt gcagcctctg gattcacctt cagtagctat ggcatgcact gggtccgcca      840

ggctccaggc aaggggctgg agtgggtggc agttatatca tatgatggaa gtaataaata      900

ctatgcagac tccgtgaagg gccgattcac catctccaga gacaattcca agaacacgct      960

gtatctgcaa atgaacagcc tgagagctga ggacacggcc gtgtattact gtgcaagagc     1020

cctcttcacg accatcgcca tggactattg gggccaaggt acccttgtca ccgtctcgag     1080

t                                                                     1081


<210>  81
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1377-CH1-IgG1 UH linker-MF1122

<400>  81

Ala Gln Pro Ala Met Ala Glu Val Gln Leu Val Glu Thr Gly Ala Glu 
1               5                   10                  15      


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Asp 
            20                  25                  30          


Tyr Ile Phe Thr Lys Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly 
        35                  40                  45              


Gln Gly Leu Glu Trp Met Gly Trp Met Ser Ala Asn Thr Gly Asn Thr 
    50                  55                  60                  


Gly Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
65                  70                  75                  80  


Ser Ile Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Gly Asp 
                85                  90                  95      


Thr Ala Val Tyr Phe Cys Ala Arg Ser Ser Leu Phe Lys Thr Glu Thr 
            100                 105                 110         


Ala Pro Tyr Tyr His Phe Ala Leu Asp Val Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
                245                 250                 255     


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            260                 265                 270         


Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        275                 280                 285             


Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser 
    290                 295                 300                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
305                 310                 315                 320 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                325                 330                 335     


Cys Ala Arg Ala Leu Phe Thr Thr Ile Ala Met Asp Tyr Trp Gly Gln 
            340                 345                 350         


Gly Thr Leu Val Thr Val Ser Ser 
        355                 360 


<210>  82
<211>  1105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding MF1377-CH1-IgG2 H linker-MF1122

<400>  82
ggcccagccg gccatggccg aggtgcagct ggtggagact ggggctgagg tgaagaagcc       60

gggggcctca gtgaaggtct cctgcaaggc ttctgactac atcttcacca aatatgacat      120

caactgggtg cgccaggccc ctggacaagg gcttgaatgg atgggatgga tgagcgctaa      180

cactggaaac acgggctatg cacagaagtt ccagggcaga gtcaccatga ccagggacac      240

gtccataaac acagcctaca tggagctgag cagcctgaca tctggtgaca cggccgttta      300

tttctgtgcg aggagtagtc ttttcaagac agagacggcg ccctactatc acttcgctct      360

ggacgtctgg ggccaaggga ccacggtcac cgtctccagt gctagcacca agggccccag      420

cgtgttcccc ctggccccct gcagccggag caccagcgag agcaccgccg ccctgggctg      480

cctggtgaag gactacttcc ccgagcccgt gaccgtgagc tggaacagcg gcgccctgac      540

cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc ggcctgtaca gcctgagcag      600

cgtggtgacg gtgcccagca gcaacttcgg cacccagacc tacacctgca acgtggacca      660

caagcccagc aacaccaagg tggacaagac cgtggagcgg aagagcagcg tggagagccc      720

ccccagcccc gccccccccg tggccggcga ggtgcagctg gtggagtctg ggggaggcgt      780

ggtccagcct gggaggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag      840

ctatggcatg cactgggtcc gccaggctcc aggcaagggg ctggagtggg tggcagttat      900

atcatatgat ggaagtaata aatactatgc agactccgtg aagggccgat tcaccatctc      960

cagagacaat tccaagaaca cgctgtatct gcaaatgaac agcctgagag ctgaggacac     1020

ggccgtgtat tactgtgcaa gagccctctt cacgaccatc gccatggact attggggcca     1080

aggtaccctt gtcaccgtct cgagt                                           1105


<210>  83
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1377-CH1-IgG2 H linker-MF1122

<400>  83

Ala Gln Pro Ala Met Ala Glu Val Gln Leu Val Glu Thr Gly Ala Glu 
1               5                   10                  15      


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Asp 
            20                  25                  30          


Tyr Ile Phe Thr Lys Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly 
        35                  40                  45              


Gln Gly Leu Glu Trp Met Gly Trp Met Ser Ala Asn Thr Gly Asn Thr 
    50                  55                  60                  


Gly Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
65                  70                  75                  80  


Ser Ile Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Gly Asp 
                85                  90                  95      


Thr Ala Val Tyr Phe Cys Ala Arg Ser Ser Leu Phe Lys Thr Glu Thr 
            100                 105                 110         


Ala Pro Tyr Tyr His Phe Ala Leu Asp Val Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
        195                 200                 205             


Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Thr Val Glu Arg Lys Ser Ser Val Glu Ser Pro 
225                 230                 235                 240 


Pro Ser Pro Ala Pro Pro Val Ala Gly Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly 
    290                 295                 300                 


Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
                325                 330                 335     


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Leu Phe Thr Thr 
            340                 345                 350         


Ile Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365             


<210>  84
<211>  1105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding MF1377-CH1-IgG2B H linker-MF1122

<400>  84
ggcccagccg gccatggccg aggtgcagct ggtggagact ggggctgagg tgaagaagcc       60

gggggcctca gtgaaggtct cctgcaaggc ttctgactac atcttcacca aatatgacat      120

caactgggtg cgccaggccc ctggacaagg gcttgaatgg atgggatgga tgagcgctaa      180

cactggaaac acgggctatg cacagaagtt ccagggcaga gtcaccatga ccagggacac      240

gtccataaac acagcctaca tggagctgag cagcctgaca tctggtgaca cggccgttta      300

tttctgtgcg aggagtagtc ttttcaagac agagacggcg ccctactatc acttcgctct      360

ggacgtctgg ggccaaggga ccacggtcac cgtctccagt gctagcacca agggccccag      420

cgtgttcccc ctggccccct ctagccggag caccagcgag agcaccgccg ccctgggctg      480

cctggtgaag gactacttcc ccgagcccgt gaccgtgagc tggaacagcg gcgccctgac      540

cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc ggcctgtaca gcctgagcag      600

cgtggtgacg gtgcccagca gcaacttcgg cacccagacc tacacctgca acgtggacca      660

caagcccagc aacaccaagg tggacaagac cgtggagcgg aagtgcagcg tggagagccc      720

ccccagcccc gccccccccg tggccggcga ggtgcagctg gtggagtctg ggggaggcgt      780

ggtccagcct gggaggtccc tgagactctc ctgtgcagcc tctggattca ccttcagtag      840

ctatggcatg cactgggtcc gccaggctcc aggcaagggg ctggagtggg tggcagttat      900

atcatatgat ggaagtaata aatactatgc agactccgtg aagggccgat tcaccatctc      960

cagagacaat tccaagaaca cgctgtatct gcaaatgaac agcctgagag ctgaggacac     1020

ggccgtgtat tactgtgcaa gagccctctt cacgaccatc gccatggact attggggcca     1080

aggtaccctt gtcaccgtct cgagt                                           1105


<210>  85
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1377-CH1-IgG2B H linker-MF1122

<400>  85

Ala Gln Pro Ala Met Ala Glu Val Gln Leu Val Glu Thr Gly Ala Glu 
1               5                   10                  15      


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Asp 
            20                  25                  30          


Tyr Ile Phe Thr Lys Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly 
        35                  40                  45              


Gln Gly Leu Glu Trp Met Gly Trp Met Ser Ala Asn Thr Gly Asn Thr 
    50                  55                  60                  


Gly Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
65                  70                  75                  80  


Ser Ile Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Gly Asp 
                85                  90                  95      


Thr Ala Val Tyr Phe Cys Ala Arg Ser Ser Leu Phe Lys Thr Glu Thr 
            100                 105                 110         


Ala Pro Tyr Tyr His Phe Ala Leu Asp Val Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
        195                 200                 205             


Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Ser Val Glu Ser Pro 
225                 230                 235                 240 


Pro Ser Pro Ala Pro Pro Val Ala Gly Glu Val Gln Leu Val Glu Ser 
                245                 250                 255     


Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala 
            260                 265                 270         


Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln 
        275                 280                 285             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly 
    290                 295                 300                 


Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
305                 310                 315                 320 


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
                325                 330                 335     


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Leu Phe Thr Thr 
            340                 345                 350         


Ile Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        355                 360                 365             


<210>  86
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF1122 DNA

<400>  86
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggccgtgt attactgtgc aagagccctc      300

ttcacgacca tcgccatgga ctattggggc caaggtaccc tggtcacc                   348


<210>  87
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1122 AA

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Phe Thr Thr Ile Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr 
        115     


<210>  88
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MF1025 DNA

<400>  88
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc aagggccgat      300

tggtgggcga cttttgacta ctggggccaa ggtaccctgg tcacc                      345


<210>  89
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MF1025 AA

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Asp Trp Trp Ala Thr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr 
        115 


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG middle hinge region

<400>  90

Cys Pro Pro Cys Pro 
1               5   


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG helix forming sequence

<400>  91

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10  


<210>  92
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  multivalent multimer lacking Fc region

<400>  92

Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10          


<210>  93
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PT23103p15 (Linker IgG1 H)

<400>  93

Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser 
1               5                   10          


