                         SEQUENCE LISTING

<110>  Ascendis Pharma A/S
 
<120>  Sustained Local Drug Levels For Innate Immune Agonists

<130>  CPX72193PC

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aldesleukin mutein

<400>  1

Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu 
1               5                   10                  15      


Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn 
            20                  25                  30          


Pro Lys Leu Thr Cys Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys 
        35                  40                  45              


Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    50                  55                  60                  


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg 
65                  70                  75                  80  


Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys 
                85                  90                  95      


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            100                 105                 110         


Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile Ile 
        115                 120                 125             


Ser Thr Leu Thr 
    130         


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ubb forward sequence

<400>  2
gtctgagggg tggctattaa                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UBB reverse sequence

<400>  3
gcttaccatg caacaaaacc                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ccl2 forward sequence

<400>  4
cagctctctc ttcctccacc                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ccl2 reverse sequence

<400>  5
tgggatcatc ttgctggtga                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ccl3 forward sequence

<400>  6
ccagccaggt gtcattttcc                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ccl3 reverse sequence

<400>  7
aggcattcag ttccaggtca                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ccl4 forward sequence

<400>  8
tctgtgctaa ccccagtgag                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ccl4 reverse sequence

<400>  9
ctctcctgaa gtggctcctc                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ccl5 forward sequence

<400>  10
tgccaaccca gagaagaagt                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ccl5 reverse sequence

<400>  11
agatgcccat tttcccagga                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Csf2 forward sequence

<400>  12
ctgcgtaatg agccaggaac                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Csf2 reverse sequence

<400>  13
tctctcgttt gtcttccgct                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cxcl1 forward sequence

<400>  14
ttgtatggtc aacacgcacg                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cxcl1 reverse sequence

<400>  15
acgagaccag gagaaacagg                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cxcl2 forward sequence

<400>  16
ctacatccca cccacacagt                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cxcl2 reverse sequence

<400>  17
tgttctactc tcctcggtgc                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cxcl10 forward sequence

<400>  18
gccgtcattt tctgcctcat                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cxcl10 reverse sequence

<400>  19
gataggctcg cagggatgat                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Il1b forward sequence

<400>  20
actcattgtg gctgtggaga                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Il1b reverse sequence

<400>  21
ttgttcatct cggagcctgt                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Il6

<400>  22
ttcttgggac tgatgctggt                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Il6 reverse sequence

<400>  23
caggtctgtt gggagtggta                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Il10 forward sequence

<400>  24
acctggtaga agtgatgccc                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Il10 reverse sequence

<400>  25
agggtcttca gcttctcacc                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Il18 forward sequence

<400>  26
ggacactttc ttgcttgcca                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Il18 reverse sequence

<400>  27
accctcccca cctaactttg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tnf forward sequence

<400>  28
tgaggtcaat ctgcccaagt                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tnf reverse sequence

<400>  29
ggggtcagag taaaggggtc                                                   20


