                         SEQUENCE LISTING

<110>  Show-Li Chen
 
<120>  METHOD FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS

<130>  191502WO

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  2583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide encoding NRIP

<400>  1
atgtctcggg gtggctccta cccacacctg ttgtgggacg tgaggaaaag gtccctcggg       60

ctggaggacc cgtcccggct gcggagtcgc tacctgggaa gaagagaatt tatccaaaga      120

ttaaaacttg aagcaaccct taatgtgcat gatggttgtg ttaatacaat ctgttggaat      180

gacactggag aatatatttt atctggctca gatgacacca aattagtaat tagtaatcct      240

tacagcagaa aggttttgac aacaattcgt tcagggcacc gagcaaacat atttagtgca      300

aagttcttac cttgtacaaa tgataaacag attgtatcct gctctggaga tggagtaata      360

ttttatacca acgttgagca agatgcagaa accaacagac aatgccaatt tacgtgtcat      420

tatggaacta cttatgagat tatgactgta cccaatgacc cttacacttt tctctcttgt      480

ggtgaagatg gaactgttag gtggtttgat acacgcatca aaactagctg cacaaaagaa      540

gattgtaaag atgatatttt aattaactgt cgacgtgctg ccacgtctgt tgctatttgc      600

ccaccaatac catattacct tgctgttggt tgttctgaca gctcagtacg aatatatgat      660

cggcgaatgc tgggcacaag agctacaggg aattatgcag gtcgagggac tactggaatg      720

gttgcccgtt ttattccttc ccatcttaat aataagtcct gcagagtgac atctctgtgt      780

tacagtgaag atggtcaaga gattctcgtt agttactctt cagattacat atatcttttt      840

gacccgaaag atgatacagc acgagaactt aaaactcctt ctgcggaaga gagaagagaa      900

gagttgcgac aaccaccagt taagcgtttg agacttcgtg gtgattggtc agatactgga      960

cccagagcaa ggccggagag tgaacgagaa cgagatggag agcagagtcc caatgtgtca     1020

ttgatgcaga gaatgtctga tatgttatca agatggtttg aagaagcaag tgaggttgca     1080

caaagcaata gaggacgagg aagatctcga cccagaggtg gaacaagtca atcagatatt     1140

tcaactcttc ctacggtccc atcaagtcct gatttggaag tgagtgaaac tgcaatggaa     1200

gtagatactc cagctgaaca atttcttcag ccttctacat cctctacaat gtcagctcag     1260

gctcattcga catcatctcc cacagaaagc cctcattcta ctcctttgct atcttctcca     1320

gacagtgaac aaaggcagtc tgttgaggca tctggacacc acacacatca tcagtctgat     1380

aacaataatg aaaagctgag ccccaaacca gggacaggtg aaccagtttt aagtttgcac     1440

tacagcacag aaggaacaac tacaagcaca ataaaactga actttacaga tgaatggagc     1500

agtatagcat caagttctag aggaattggg agccattgca aatctgaggg tcaggaggaa     1560

tctttcgtcc cacagagctc agtgcaacca ccagaaggag acagtgaaac aaaagctcct     1620

gaagaatcat cagaggatgt gacaaaatat caggaaggag tatctgcaga aaacccagtt     1680

gagaaccata tcaatataac acaatcagat aagttcacag ccaagccatt ggattccaac     1740

tcaggagaaa gaaatgacct caatcttgat cgctcttgtg gggttccaga agaatctgct     1800

tcatctgaaa aagccaagga accagaaact tcagatcaga ctagcactga gagtgctacc     1860

aatgaaaata acaccaatcc tgagcctcag ttccaaacag aagccactgg gccttcagct     1920

catgaagaaa catccaccag ggactctgct cttcaggaca cagatgacag tgatgatgac     1980

ccagtcctga tcccaggtgc aaggtatcga gcaggacctg gtgatagacg ctctgctgtt     2040

gcccgtattc aggagttctt cagacggaga aaagaaagga aagaaatgga agaattggat     2100

actttgaaca ttagaaggcc gctagtaaaa atggtttata aaggccatcg caactccagg     2160

acaatgataa aagaagccaa tttctggggt gctaactttg taatgagtgg ttctgactgt     2220

ggccacattt tcatctggga tcggcacact gctgagcatt tgatgcttct ggaagctgat     2280

aatcatgtgg taaactgcct gcagccacat ccgtttgacc caattttagc ctcatctggc     2340

atagattatg acataaagat ctggtcacca ttagaagagt caaggatttt taaccgaaaa     2400

cttgctgatg aagttataac tcgaaacgaa ctcatgctgg aagaaactag aaacaccatt     2460

acagttccag cctctttcat gttgaggatg ttggcttcac ttaatcatat ccgagctgac     2520

cggttggagg gtgacagatc agaaggctct ggtcaagaga atgaaaatga ggatgaggaa     2580

taa                                                                   2583


<210>  2
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NRIP peptide

<400>  2

Met Ser Arg Gly Gly Ser Tyr Pro His Leu Leu Trp Asp Val Arg Lys 
1               5                   10                  15      


Arg Ser Leu Gly Leu Glu Asp Pro Ser Arg Leu Arg Ser Arg Tyr Leu 
            20                  25                  30          


Gly Arg Arg Glu Phe Ile Gln Arg Leu Lys Leu Glu Ala Thr Leu Asn 
        35                  40                  45              


Val His Asp Gly Cys Val Asn Thr Ile Cys Trp Asn Asp Thr Gly Glu 
    50                  55                  60                  


Tyr Ile Leu Ser Gly Ser Asp Asp Thr Lys Leu Val Ile Ser Asn Pro 
65                  70                  75                  80  


Tyr Ser Arg Lys Val Leu Thr Thr Ile Arg Ser Gly His Arg Ala Asn 
                85                  90                  95      


Ile Phe Ser Ala Lys Phe Leu Pro Cys Thr Asn Asp Lys Gln Ile Val 
            100                 105                 110         


Ser Cys Ser Gly Asp Gly Val Ile Phe Tyr Thr Asn Val Glu Gln Asp 
        115                 120                 125             


Ala Glu Thr Asn Arg Gln Cys Gln Phe Thr Cys His Tyr Gly Thr Thr 
    130                 135                 140                 


Tyr Glu Ile Met Thr Val Pro Asn Asp Pro Tyr Thr Phe Leu Ser Cys 
145                 150                 155                 160 


Gly Glu Asp Gly Thr Val Arg Trp Phe Asp Thr Arg Ile Lys Thr Ser 
                165                 170                 175     


Cys Thr Lys Glu Asp Cys Lys Asp Asp Ile Leu Ile Asn Cys Arg Arg 
            180                 185                 190         


Ala Ala Thr Ser Val Ala Ile Cys Pro Pro Ile Pro Tyr Tyr Leu Ala 
        195                 200                 205             


Val Gly Cys Ser Asp Ser Ser Val Arg Ile Tyr Asp Arg Arg Met Leu 
    210                 215                 220                 


Gly Thr Arg Ala Thr Gly Asn Tyr Ala Gly Arg Gly Thr Thr Gly Met 
225                 230                 235                 240 


Val Ala Arg Phe Ile Pro Ser His Leu Asn Asn Lys Ser Cys Arg Val 
                245                 250                 255     


Thr Ser Leu Cys Tyr Ser Glu Asp Gly Gln Glu Ile Leu Val Ser Tyr 
            260                 265                 270         


Ser Ser Asp Tyr Ile Tyr Leu Phe Asp Pro Lys Asp Asp Thr Ala Arg 
        275                 280                 285             


Glu Leu Lys Thr Pro Ser Ala Glu Glu Arg Arg Glu Glu Leu Arg Gln 
    290                 295                 300                 


Pro Pro Val Lys Arg Leu Arg Leu Arg Gly Asp Trp Ser Asp Thr Gly 
305                 310                 315                 320 


Pro Arg Ala Arg Pro Glu Ser Glu Arg Glu Arg Asp Gly Glu Gln Ser 
                325                 330                 335     


Pro Asn Val Ser Leu Met Gln Arg Met Ser Asp Met Leu Ser Arg Trp 
            340                 345                 350         


Phe Glu Glu Ala Ser Glu Val Ala Gln Ser Asn Arg Gly Arg Gly Arg 
        355                 360                 365             


Ser Arg Pro Arg Gly Gly Thr Ser Gln Ser Asp Ile Ser Thr Leu Pro 
    370                 375                 380                 


Thr Val Pro Ser Ser Pro Asp Leu Glu Val Ser Glu Thr Ala Met Glu 
385                 390                 395                 400 


Val Asp Thr Pro Ala Glu Gln Phe Leu Gln Pro Ser Thr Ser Ser Thr 
                405                 410                 415     


Met Ser Ala Gln Ala His Ser Thr Ser Ser Pro Thr Glu Ser Pro His 
            420                 425                 430         


Ser Thr Pro Leu Leu Ser Ser Pro Asp Ser Glu Gln Arg Gln Ser Val 
        435                 440                 445             


Glu Ala Ser Gly His His Thr His His Gln Ser Asp Asn Asn Asn Glu 
    450                 455                 460                 


Lys Leu Ser Pro Lys Pro Gly Thr Gly Glu Pro Val Leu Ser Leu His 
465                 470                 475                 480 


Tyr Ser Thr Glu Gly Thr Thr Thr Ser Thr Ile Lys Leu Asn Phe Thr 
                485                 490                 495     


Asp Glu Trp Ser Ser Ile Ala Ser Ser Ser Arg Gly Ile Gly Ser His 
            500                 505                 510         


Cys Lys Ser Glu Gly Gln Glu Glu Ser Phe Val Pro Gln Ser Ser Val 
        515                 520                 525             


Gln Pro Pro Glu Gly Asp Ser Glu Thr Lys Ala Pro Glu Glu Ser Ser 
    530                 535                 540                 


Glu Asp Val Thr Lys Tyr Gln Glu Gly Val Ser Ala Glu Asn Pro Val 
545                 550                 555                 560 


Glu Asn His Ile Asn Ile Thr Gln Ser Asp Lys Phe Thr Ala Lys Pro 
                565                 570                 575     


Leu Asp Ser Asn Ser Gly Glu Arg Asn Asp Leu Asn Leu Asp Arg Ser 
            580                 585                 590         


Cys Gly Val Pro Glu Glu Ser Ala Ser Ser Glu Lys Ala Lys Glu Pro 
        595                 600                 605             


Glu Thr Ser Asp Gln Thr Ser Thr Glu Ser Ala Thr Asn Glu Asn Asn 
    610                 615                 620                 


Thr Asn Pro Glu Pro Gln Phe Gln Thr Glu Ala Thr Gly Pro Ser Ala 
625                 630                 635                 640 


His Glu Glu Thr Ser Thr Arg Asp Ser Ala Leu Gln Asp Thr Asp Asp 
                645                 650                 655     


Ser Asp Asp Asp Pro Val Leu Ile Pro Gly Ala Arg Tyr Arg Ala Gly 
            660                 665                 670         


Pro Gly Asp Arg Arg Ser Ala Val Ala Arg Ile Gln Glu Phe Phe Arg 
        675                 680                 685             


Arg Arg Lys Glu Arg Lys Glu Met Glu Glu Leu Asp Thr Leu Asn Ile 
    690                 695                 700                 


Arg Arg Pro Leu Val Lys Met Val Tyr Lys Gly His Arg Asn Ser Arg 
705                 710                 715                 720 


Thr Met Ile Lys Glu Ala Asn Phe Trp Gly Ala Asn Phe Val Met Ser 
                725                 730                 735     


Gly Ser Asp Cys Gly His Ile Phe Ile Trp Asp Arg His Thr Ala Glu 
            740                 745                 750         


His Leu Met Leu Leu Glu Ala Asp Asn His Val Val Asn Cys Leu Gln 
        755                 760                 765             


Pro His Pro Phe Asp Pro Ile Leu Ala Ser Ser Gly Ile Asp Tyr Asp 
    770                 775                 780                 


Ile Lys Ile Trp Ser Pro Leu Glu Glu Ser Arg Ile Phe Asn Arg Lys 
785                 790                 795                 800 


Leu Ala Asp Glu Val Ile Thr Arg Asn Glu Leu Met Leu Glu Glu Thr 
                805                 810                 815     


Arg Asn Thr Ile Thr Val Pro Ala Ser Phe Met Leu Arg Met Leu Ala 
            820                 825                 830         


Ser Leu Asn His Ile Arg Ala Asp Arg Leu Glu Gly Asp Arg Ser Glu 
        835                 840                 845             


Gly Ser Gly Gln Glu Asn Glu Asn Glu Asp Glu Glu 
    850                 855                 860 


